Hub : Genes

LOC120094201

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL alternative TSS XR_005488288.1 0.03 0.04 1.0e-03 0.03 0.03 0.03 0.03 8.6e-04 5.3e-04 8.9e-04 8.0e-04
2 Adipose gene expression LOC120094201 0.07 0.06 1.7e-07 0.06 0.05 0.05 0.05 9.8e-07 1.5e-06 1.5e-06 1.5e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.50.90.9-1.00.9
Area under the delay curve0.10.10.10.4-0.3
BMI with tail6.420.821.14.6-4.5
BMI without tail2.96.16.12.5-2.5
Body weight4.820.220.54.5-4.5
Weight adjusted by age5.96.76.92.6-2.5
Bone surface0.00.10.10.3-0.3
Bone volume0.00.00.0-0.1-0.0
Breakpoint value in progressive ratio session0.30.30.40.6-0.5
Number of licking bursts2.53.03.2-1.81.7
Context. condit. distance diff. score1.01.21.2-1.11.1
Locomotion velocity, session 10.30.30.30.6-0.5
Locomotion distance, session 10.70.91.0-0.91.0
Locomotion velocity, session 20.00.00.00.10.0
Locomotion distance, session 20.00.00.00.00.1
Locomotion velocity, session 30.10.10.2-0.40.3
Locomotion distance, session 32.52.73.0-1.71.6
Stereotopy head waving bouts, day 31.11.31.31.1-1.1
Stereotopy head waving duration, day 31.21.41.51.2-1.2
Locomotion velocity, session 72.73.03.1-1.71.8
Locomotion distance, session 72.32.93.2-1.61.8
Stereotopy head waving bouts, day 72.42.62.71.6-1.6
Stereotopy head waving duration, day 72.22.62.71.6-1.6
Locomotion velocity, session 80.00.00.0-0.1-0.0
Locomotion distance, session 81.21.71.8-1.31.3
Degree of sensitization distance0.10.10.2-0.20.4
Degree of sensitization stereotypy1.31.41.51.2-1.2
Conditioned locomotion0.10.10.1-0.30.2
Cocaine response after cond. corrected3.23.63.61.9-1.9
Cocaine response after cond. not corrected1.51.61.81.3-1.2
Cocaine response before conditioning1.21.51.6-1.21.3
Saline control response0.00.00.0-0.00.1
Bone: connectivity density1.11.71.8-1.41.2
Bone: cortical apparent density0.50.60.6-0.80.8
Bone: cortical area0.00.00.0-0.20.0
Bone: cortical porosity0.50.60.6-0.70.8
Bone: cortical porosity1.61.71.8-1.31.3
Bone: cortical thickness1.32.12.4-1.51.4
Bone: cortical thickness1.11.31.5-1.21.0
Bone: cortical tissue density0.50.60.6-0.80.8
Condit. Reinf. active minus inactive responses0.00.00.0-0.10.2
Condit. Reinf. active-inactive response ratio0.60.60.6-0.80.8
Condit. Reinf. active responses0.30.40.40.6-0.6
Condit. Reinf. inactive responses1.11.31.41.1-1.2
Incentive salience index mean0.00.00.1-0.20.2
Condit. Reinf. lever presses0.20.20.2-0.40.5
Condit. Reinf. active minus inactive responses2.43.03.01.7-1.7
Condit. Reinf. active-inactive response ratio1.11.21.21.1-1.1
Condit. Reinf. active responses0.91.31.41.2-1.1
Condit. Reinf. inactive responses0.20.20.2-0.40.5
Condit. Reinf. lever presses0.81.11.2-1.01.1
Condit. Reinf. lever reinforcers received0.50.70.70.8-0.8
Conditioned reinforcement - actives0.50.50.50.7-0.7
Conditioned reinforcement - inactives0.00.00.00.1-0.2
Conditioned locomotion0.20.20.3-0.50.4
Patch foraging indifference point 0 sec0.10.10.10.4-0.3
Patch foraging indifference point AUC0.00.00.1-0.20.1
Delay disc. indifference point, 0s delay0.10.10.1-0.20.3
Delay disc. indifference point, 16s delay0.00.00.00.1-0.1
Delay disc. indifference point, 2s delay0.00.00.00.2-0.1
Delay disc. indifference point, 24s delay0.10.10.1-0.30.3
Delay disc. indifference point, 4s delay0.00.00.00.10.0
Delay disc. indifference point, 8s delay0.10.10.20.4-0.3
Indifference point function ln k0.40.50.60.8-0.7
Indifference point function log k0.40.50.60.8-0.7
Patch foraging total patch changes 0 sec0.10.20.20.5-0.4
Patch foraging total patch changes 12 sec0.00.10.1-0.30.2
Patch foraging total patch changes 18 sec0.10.10.20.3-0.4
Patch foraging total patch changes 24 sec0.00.00.0-0.20.1
Patch foraging total patch changes 6 sec0.20.20.20.5-0.5
Patch foraging time to switch 0 sec0.81.21.3-1.11.1
Patch foraging water rate 0 sec1.93.13.21.8-1.7
Patch foraging water rate 12 sec2.84.34.42.1-2.0
Patch foraging water rate 18 sec0.20.30.40.6-0.4
Patch foraging water rate 24 sec0.10.10.20.4-0.3
Patch foraging water rate 6 sec1.11.61.71.3-1.2
Seeking ratio, delayed vs. immediate footshock0.70.80.80.9-0.9
Distance traveled before self-admin0.60.60.70.7-0.9
Distance traveled after self-admin1.82.02.11.4-1.5
Extensor digitorum longus weight8.232.132.35.6-5.7
Bone: elastic displacement0.40.50.50.7-0.7
Bone: elastic work0.00.00.00.0-0.2
Bone: endosteal estimation2.24.85.02.1-2.2
Bone: endosteal perimeter3.47.07.52.5-2.7
Epididymis fat weight0.00.10.10.2-0.2
Delta time in closed arm before/after self-admin0.10.10.1-0.30.2
Delta time in open arm before/after self-admin1.11.01.1-1.01.0
Diff in mean of infusions in LGA sessions1.41.51.81.3-1.1
Delay discount exponential model param0.20.20.3-0.50.4
Extinction: sum of active levers before priming0.00.00.0-0.10.2
Active lever presses in extinction session 60.00.00.00.2-0.1
Bone: final force0.30.50.60.6-0.8
Bone: final moment0.10.10.10.2-0.4
Food consumed during 24 hour testing period1.31.61.81.2-1.3
Glucose0.30.50.60.6-0.8
Heart weight0.50.70.80.8-0.9
Delay discount hyperbolic model param0.10.10.1-0.40.3
Intermittent access intake day 1-15 change0.90.90.9-0.91.0
Intermittent access intake escalation1.11.11.1-1.01.1
Intermittent access intake escalation 20.00.00.00.1-0.2
Intermitt. access day 1 inactive lever presses1.71.81.9-1.41.3
Intermitt. access day 15 inactive lever presses0.00.00.0-0.1-0.1
Intermitt. access escalation Index1.41.31.31.1-1.1
Intermittent access day 1 total infusions0.20.20.3-0.50.4
Intermittent access day 15 total infusions0.80.90.9-1.00.9
Intermittent access terminal intake (last 3 days)0.10.10.2-0.40.3
Intermittent access total infusions0.10.10.1-0.40.3
Intermittent access day 1 locomotion1.61.71.7-1.31.3
Intermittent access day 15 total locomotion1.41.51.6-1.31.2
Intermittent access total locomotion0.00.00.00.1-0.1
Intermittent access standard deviation0.90.91.0-0.91.0
Left kidney weight2.98.08.12.8-2.8
Right kidney weight2.87.88.02.8-2.8
Cocaine induced anxiety0.00.00.0-0.20.2
Post-drug Anxiety2.02.22.3-1.51.5
Baseline Anxiety0.60.60.7-0.70.8
Tail length0.10.20.20.4-0.5
Length with tail0.83.03.11.7-1.8
Length without tail2.45.35.52.4-2.3
Times rat made contact with spout0.10.10.1-0.30.3
Lifetime Intake0.20.30.4-0.60.5
Liver weight, left0.50.70.80.8-0.9
Liver weight, right1.32.12.51.3-1.6
Locomotor activity6.710.610.83.3-3.2
Locomotor testing distance3.55.96.22.5-2.4
Locomotor testing rearing2.03.13.61.9-1.6
Locomotion in novel chamber0.70.80.8-0.90.9
Locomotion in novel chamber post-restriction0.20.30.3-0.50.6
Fecal boli incidents, locomotor time 10.00.00.00.0-0.1
Change in fecal boli incidents, locomotor task0.00.00.00.0-0.1
Time >=10cm from walls, locomotor time 10.30.30.40.4-0.6
Bouts of movement, locomotor time 10.00.00.00.2-0.1
Total resting periods, locomotor time 10.00.00.00.2-0.1
Rest time, locomotor task time 10.00.00.0-0.20.1
Distance moved, locomotor task time 10.10.10.1-0.30.3
Vertical activity count, locomotor time 10.00.00.0-0.10.1
Time >=10cm from walls, locomotor time 20.00.00.0-0.20.1
Bouts of movement, locomotor time 22.22.42.41.6-1.5
Total resting periods, locomotor time 22.52.72.71.6-1.6
Rest time, locomotor task time 20.20.20.2-0.50.4
Distance moved, locomotor task time 20.10.10.1-0.30.4
Vertical activity count, locomotor time 20.20.20.2-0.40.4
Light reinforcement 12.34.14.42.0-2.1
Light reinforcement 20.40.50.6-0.80.7
Bone: marrow area2.24.95.12.2-2.3
Bone: maximum diameter1.93.53.91.8-2.0
Bone: maximum force0.50.81.00.8-1.0
Bone: maximum moment0.20.30.30.5-0.6
Mean time between licks in bursts0.20.30.4-0.60.6
Mean num. licks in bursts1.51.81.91.4-1.3
Cd content in liver0.00.00.1-0.20.1
Co content in liver0.10.10.1-0.30.2
Cu content in liver0.20.20.40.3-0.6
Fe content in liver0.40.50.5-0.70.6
K content in liver2.02.02.01.4-1.4
Mg content in liver3.53.63.81.9-1.9
Mn content in liver0.00.00.10.1-0.2
Na content in liver1.81.92.01.4-1.4
Rb content in liver1.82.22.31.5-1.4
Se content in liver0.30.40.4-0.60.7
Sr content in liver0.00.00.0-0.20.2
Zn content in liver0.30.40.4-0.60.6
Bone: minimum diameter0.00.00.00.0-0.1
Time in familiar zone, hab. session 10.20.20.3-0.30.5
Time in novel zone, hab. session 10.00.00.0-0.0-0.2
Total zone transitions, hab. session 11.01.41.5-1.21.1
Total locomotion distance, hab. session 10.10.20.2-0.50.4
Locomotion velocity, hab. session 10.00.00.0-0.10.0
Time in familiar zone, hab. session 20.20.20.2-0.30.5
Time in novel zone, hab. session 20.00.00.0-0.0-0.1
Total zone transitions, hab. session 20.00.00.10.1-0.2
Total locomotion distance, hab. session 20.50.70.80.7-0.9
Locomotion velocity, hab. session 20.20.30.40.5-0.6
Novel to familiar place preference ratio1.51.51.71.3-1.2
Novelty place preference1.51.51.71.3-1.1
Time in novel zone, NPP test1.71.82.01.4-1.3
Total zone transitions, NPP test0.00.10.10.2-0.3
Total locomotion distance, NPP test0.40.60.60.8-0.8
Locomotion velocity, NPP test0.10.20.20.5-0.4
Intraocular pressure0.00.00.10.1-0.3
Delta distance traveled before/after self-admin0.40.50.50.7-0.7
Delta ambulatory time before/after self-admin0.10.10.10.3-0.2
Parametrial fat weight0.00.00.0-0.2-0.1
Pavlov. Cond. lever latency0.00.00.1-0.30.2
Pavlov. Cond. magazine entry latency1.11.41.4-1.21.2
Pavlov. Cond. change in total contacts0.00.00.00.1-0.1
Pavlov. Cond. index score0.70.91.0-0.91.0
Pavlov. Cond. latency score0.30.40.5-0.60.7
Pavlov. Cond. lever contacts0.10.10.1-0.30.3
Pavlov. Cond. magazine entry number1.31.61.61.3-1.2
Pavlov. Cond. intertrial magazine entries0.00.00.00.2-0.1
Pavlov. Cond. lever-magazine prob. diff.0.50.70.7-0.80.8
Pavlov. Cond. response bias0.50.70.7-0.80.8
Pavlov. Cond. lever latency1.01.41.41.2-1.2
Pavlov. Cond. magazine entry latency3.74.24.2-2.12.0
Pavlov. Cond. change in total contacts0.50.60.7-0.80.8
Pavlov. Cond. index score1.41.81.9-1.31.4
Pavlov. Cond. latency score0.91.11.2-1.01.1
Pavlov. Cond. lever contacts0.40.50.5-0.70.7
Pavlov. Cond. magazine entry number3.64.44.42.1-2.1
Pavlov. Cond. intertrial magazine entries0.50.70.70.8-0.8
Pavlov. Cond. lever-magazine prob. diff.1.62.02.1-1.41.4
Pavlov. Cond. response bias1.31.81.8-1.31.4
Time in closed arm before self-admin0.00.00.00.10.0
Time in closed arm after self-admin0.00.00.00.10.0
Time in open arm before self-admin0.70.80.80.9-0.9
Time in open arm after self-admin0.00.00.1-0.20.2
Bone: periosteal estimation1.32.62.91.5-1.7
Bone: periosteal perimeter1.93.23.61.7-1.9
Bone: post-yield work0.10.20.20.4-0.5
Progressive ratio test 1 active lever presses0.20.20.20.4-0.5
Progressive ratio test 1 breakpoint0.00.00.00.0-0.1
Progressive ratio test 1 inactive lever presses1.11.31.5-1.21.0
Progressive ratio test 2 active lever presses0.30.30.30.6-0.6
Progressive ratio test 2 breakpoint0.50.50.50.7-0.7
Progressive ratio test 2 inactive lever presses0.30.40.4-0.60.6
Incentive Sensitization - Responses0.50.50.50.7-0.7
Incentive Sensitization - Breakpoint0.20.20.30.5-0.5
Sum of active levers in priming session hrs 5-60.00.00.00.2-0.1
Progressive ratio0.20.30.3-0.50.5
Food seeking constrained by brief footshock0.50.60.70.7-0.9
Seeking ratio, punishment vs. effort2.32.82.91.6-1.7
Retroperitoneal fat weight0.00.10.10.1-0.3
Reaction time number correct1.92.72.81.7-1.6
Reaction time mean minus median0.30.30.4-0.50.7
Reaction time mean minus median AUC1.11.41.6-1.11.3
Reaction time num false alarms0.91.21.3-1.11.0
Reaction time num false alarms AUC0.30.40.5-0.70.6
Reaction time trials correct on left1.92.72.81.7-1.6
Reaction time trials on left2.02.92.91.7-1.7
Reaction time mean3.34.64.6-2.22.1
Reaction time mean AUC2.53.43.4-1.81.8
Median of all reaction times4.66.36.5-2.52.5
Reaction time omissions0.30.40.50.6-0.7
Reaction time false alarm rate1.92.62.8-1.71.6
Reaction time premature initiation rate1.52.02.01.4-1.4
Reaction time premature initiations2.73.94.02.0-1.9
Std. dev. reaction times1.31.81.8-1.31.4
Reaction time trials completed2.02.92.91.7-1.7
Reaction time trials AUC1.72.42.51.6-1.5
Run reversals in cocaine runway, females0.00.00.10.0-0.3
Run reversals in cocaine runway, males0.00.00.0-0.0-0.0
Latency to leave start box in cocaine runway2.83.13.41.8-1.7
Latency to leave start box in cocaine runway, F0.60.60.80.9-0.7
Latency to leave start box in cocaine runway, M4.44.34.42.0-2.1
Std. dev. time between licks in bursts0.20.20.20.5-0.5
Total sessions with >9 infusions0.00.00.1-0.30.1
Short access day 1 total inactive lever presses0.10.20.3-0.50.1
Short access day 10 total inactive lever presses0.50.50.6-0.80.7
Short access day 1 total infusions0.20.20.3-0.50.4
Short access day 10 total infusions0.30.30.4-0.60.5
Short access total infusions0.70.81.0-1.00.8
Short access day 1 locomotion0.00.00.1-0.3-0.0
Short access day 10 total locomotion0.00.00.00.0-0.0
Short access total locomotion0.80.91.0-1.00.9
One hour access (0.3 mA shock)0.20.30.40.4-0.6
Compulsive drug intake0.20.20.30.3-0.6
One hour access (shock baseline)0.10.10.1-0.40.3
Social response proportion0.00.00.1-0.10.2
Social responses0.00.00.00.2-0.0
Social time0.10.10.20.5-0.2
Soleus weight16.046.948.26.9-6.8
Bone: stiffness1.32.12.21.4-1.5
Tibialis anterior weight12.743.443.56.6-6.6
Time to tail flick, vehicle, before self-admin0.20.20.3-0.40.5
Time to tail flick, vehicle, after self-admin0.00.00.00.10.0
Time to tail flick, test, before self-admin0.90.91.0-1.00.9
Time to tail flick, test, after self-admin0.50.50.6-0.70.8
Delta time to tail flick, vehicle, before/after SA0.00.00.0-0.10.0
Delta time to tail flick, test, before/after SA0.10.10.10.4-0.3
Tibia length0.00.00.1-0.20.1
Ambulatory time before self-admin0.00.00.10.1-0.3
Ambulatory time after self-admin0.50.60.60.7-0.8
Bone: tissue strength1.51.51.6-1.21.3
Total heroin consumption2.32.73.11.8-1.5
Bone: trabecular number1.72.72.9-1.71.6
Bone: trabecular spacing0.00.00.00.1-0.1
Bone: trabecular thickness0.20.20.3-0.60.4
Bone: trabecular tissue density4.66.57.12.7-2.4
Water consumed over 24 hours0.20.30.3-0.60.5
Number of responses in last shaping day0.00.00.0-0.00.1