Ccl21

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Ccl21	0.09	0.06	5.2e-10	0.08	0.08	0.11	0.09	2.1e-09	2.8e-09	8.9e-12	3.1e-10
2	PL	gene expression	Ccl21	0.11	0.06	1.6e-13	0.13	0.13	0.13	0.13	3.8e-14	6.9e-14	5.0e-14	6.9e-14
3	Brain	gene expression	Ccl21	0.05	0.04	3.4e-04	0.03	0.02	0.04	0.01	4.0e-04	9.7e-03	2.5e-04	4.9e-02
4	IL	gene expression	Ccl21	0.3	0.16	8.6e-06	0.21	0.2	0.19	0.2	1.0e-05	1.5e-05	2.9e-05	1.7e-05
5	IC	gene expression	Ccl21	0.11	0.07	2.6e-03	0.03	0.01	0.02	0.02	2.6e-02	1.0e-01	6.4e-02	4.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.2	2.2	3.3	-1.8	1.2	1.5	1.0	1.7
Area under the delay curve	0.4	0.6	0.9	0.7	-0.5	-0.8	-0.9	-1.0
BMI with tail	1.5	5.3	5.9	-2.4	2.2	2.4	2.0	2.4
BMI without tail	1.3	6.7	7.5	-2.7	2.5	2.7	2.4	2.6
Body weight	3.2	14.1	15.9	-3.8	4.0	3.8	3.8	3.4
Weight adjusted by age	0.0	0.0	0.1	-0.2	0.3	0.2	0.3	0.0
Bone surface	0.8	1.5	2.2	-1.5	1.2	1.2	1.1	1.2
Bone volume	0.6	1.3	2.1	-1.4	1.0	1.1	0.8	1.2
Breakpoint value in progressive ratio session	0.8	1.4	4.1	1.3	-0.3	-0.9	-0.7	-2.0
Number of licking bursts	2.6	7.9	9.3	-3.1	2.7	2.8	2.7	2.8
Context. condit. distance diff. score	0.1	0.1	0.2	0.2	-0.4	-0.3	-0.3	-0.2
Locomotion velocity, session 1	0.5	0.6	1.2	-0.3	1.0	0.4	1.1	-0.5
Locomotion distance, session 1	0.2	0.3	0.7	-0.2	0.9	0.5	0.7	0.0
Locomotion velocity, session 2	2.1	2.5	3.4	-1.6	1.5	1.7	1.3	1.8
Locomotion distance, session 2	2.2	3.1	4.5	-1.5	2.1	1.8	1.8	1.4
Locomotion velocity, session 3	0.1	0.1	0.3	-0.1	0.5	0.1	0.6	-0.3
Locomotion distance, session 3	1.9	2.2	3.2	-1.3	1.8	1.5	1.5	1.3
Stereotopy head waving bouts, day 3	0.2	0.2	0.7	0.3	-0.1	-0.4	0.2	-0.8
Stereotopy head waving duration, day 3	0.2	0.3	0.8	0.3	-0.5	-0.6	-0.0	-0.9
Locomotion velocity, session 7	0.1	0.1	0.1	0.1	-0.2	-0.3	-0.2	-0.3
Locomotion distance, session 7	0.2	0.3	0.7	-0.4	0.8	0.5	0.4	0.3
Stereotopy head waving bouts, day 7	1.3	1.5	2.4	-1.3	1.1	1.1	1.6	0.9
Stereotopy head waving duration, day 7	0.7	0.9	1.6	-1.0	0.8	0.8	1.3	0.6
Locomotion velocity, session 8	0.1	0.1	0.3	-0.4	0.3	0.1	0.6	-0.3
Locomotion distance, session 8	0.2	0.3	0.6	-0.3	0.8	0.5	0.7	0.1
Degree of sensitization distance	0.9	1.0	1.1	1.0	-1.0	-1.0	-1.0	-1.0
Degree of sensitization stereotypy	1.5	1.6	2.0	-1.4	1.1	1.2	1.4	1.2
Conditioned locomotion	0.0	0.0	0.1	0.1	0.2	-0.1	0.3	-0.3
Cocaine response after cond. corrected	1.4	2.1	3.5	1.7	-1.0	-1.4	-1.0	-1.9
Cocaine response after cond. not corrected	1.2	1.7	3.0	1.7	-0.8	-1.3	-0.8	-1.7
Cocaine response before conditioning	0.9	1.0	1.2	-1.0	1.0	1.0	0.9	1.1
Saline control response	1.0	1.5	2.5	-1.1	1.4	1.1	1.6	0.6
Bone: connectivity density	0.6	0.9	1.7	-1.3	0.6	0.9	0.5	1.2
Bone: cortical apparent density	0.1	0.1	0.3	-0.3	-0.1	0.2	-0.0	0.6
Bone: cortical area	2.8	4.6	6.2	-2.3	1.9	2.2	1.7	2.5
Bone: cortical porosity	0.3	0.3	0.3	0.6	-0.6	-0.5	-0.5	-0.5
Bone: cortical porosity	0.0	0.0	0.0	0.2	-0.1	-0.1	0.1	-0.1
Bone: cortical thickness	1.0	1.6	3.2	-1.3	0.9	1.3	0.7	1.8
Bone: cortical thickness	0.2	0.2	0.5	0.5	-0.6	-0.3	-0.7	0.0
Bone: cortical tissue density	0.0	0.1	0.2	-0.2	-0.2	0.1	-0.1	0.5
Condit. Reinf. active minus inactive responses	0.5	0.6	0.9	-0.7	0.7	0.8	0.7	0.9
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.9	0.7	-1.0	-0.8	-0.9	-0.7
Condit. Reinf. active responses	3.0	3.8	4.7	-2.0	1.8	2.0	1.8	2.2
Condit. Reinf. inactive responses	3.5	4.5	5.6	-2.3	1.9	2.1	1.8	2.4
Incentive salience index mean	4.6	5.8	6.3	-2.4	2.4	2.5	2.4	2.4
Condit. Reinf. lever presses	10.5	15.7	17.1	-3.9	4.1	4.0	4.1	3.6
Condit. Reinf. active minus inactive responses	0.6	0.9	1.2	-0.9	1.0	1.0	0.8	1.1
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.2	-0.1	0.3	0.3	0.1	0.5
Condit. Reinf. active responses	2.4	3.5	3.8	-1.8	1.9	1.9	1.7	1.9
Condit. Reinf. inactive responses	3.0	4.5	5.1	-2.3	2.0	2.2	1.9	2.3
Condit. Reinf. lever presses	2.8	4.1	5.6	-2.1	1.8	2.1	1.6	2.4
Condit. Reinf. lever reinforcers received	2.9	4.0	4.4	-2.0	2.0	2.1	1.8	2.1
Conditioned reinforcement - actives	0.1	0.2	0.5	0.1	0.7	0.0	0.7	-0.3
Conditioned reinforcement - inactives	0.1	0.2	0.6	0.3	0.1	-0.4	0.3	-0.8
Conditioned locomotion	0.1	0.2	0.6	0.3	0.8	-0.0	0.4	0.0
Patch foraging indifference point 0 sec	0.1	0.4	0.7	-0.8	0.8	0.1	0.7	-0.4
Patch foraging indifference point AUC	4.0	9.5	11.5	-2.7	3.4	3.3	3.0	3.0
Delay disc. indifference point, 0s delay	0.9	1.1	1.8	0.9	-0.8	-1.1	-0.9	-1.3
Delay disc. indifference point, 16s delay	0.6	0.8	2.2	0.0	-0.6	-0.9	-0.7	-1.5
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.4	0.2	0.2	0.1	0.4
Delay disc. indifference point, 24s delay	0.1	0.1	0.4	0.2	-0.4	-0.3	-0.6	-0.2
Delay disc. indifference point, 4s delay	0.3	0.3	0.7	0.9	-0.1	-0.4	-0.6	-0.3
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.1	0.2	-0.0	-0.2	0.1
Indifference point function ln k	1.1	3.3	3.7	1.7	-1.9	-1.9	-1.7	-1.8
Indifference point function log k	1.1	3.3	3.7	1.7	-1.9	-1.9	-1.7	-1.8
Patch foraging total patch changes 0 sec	0.3	0.9	1.5	-1.2	1.2	0.6	1.1	0.0
Patch foraging total patch changes 12 sec	1.9	2.5	2.8	-1.7	1.7	1.6	1.5	1.4
Patch foraging total patch changes 18 sec	0.4	0.9	1.6	-1.3	1.1	0.9	0.8	0.6
Patch foraging total patch changes 24 sec	0.8	2.6	3.2	-1.6	1.8	1.6	1.7	1.4
Patch foraging total patch changes 6 sec	2.0	3.4	4.6	-2.0	2.1	1.8	2.0	1.2
Patch foraging time to switch 0 sec	0.9	3.3	4.3	1.6	-2.1	-1.8	-1.9	-1.6
Patch foraging water rate 0 sec	0.6	2.1	2.9	-1.3	1.7	1.4	1.7	1.1
Patch foraging water rate 12 sec	0.0	0.1	0.2	0.5	0.2	0.0	0.2	-0.0
Patch foraging water rate 18 sec	0.2	0.4	1.0	-0.2	0.5	0.7	0.6	1.0
Patch foraging water rate 24 sec	0.1	0.1	0.2	0.2	-0.5	-0.0	-0.3	0.3
Patch foraging water rate 6 sec	1.1	1.6	2.1	-1.1	1.3	1.2	1.5	1.2
Seeking ratio, delayed vs. immediate footshock	3.5	5.0	5.8	-2.4	2.1	2.3	2.2	2.2
Distance traveled before self-admin	3.2	6.9	8.4	-2.7	2.9	2.6	2.8	1.9
Distance traveled after self-admin	2.1	3.6	3.9	-1.9	1.9	1.8	2.0	1.9
Extensor digitorum longus weight	5.6	22.4	27.9	-5.3	4.7	4.8	4.6	4.3
Bone: elastic displacement	6.2	7.8	10.1	2.7	-2.9	-2.8	-3.2	-2.2
Bone: elastic work	2.2	2.8	5.0	1.2	-2.1	-1.6	-2.2	-0.8
Bone: endosteal estimation	1.1	2.8	3.6	-1.7	1.8	1.6	1.9	1.3
Bone: endosteal perimeter	1.0	2.5	3.4	-1.4	1.8	1.6	1.8	1.2
Epididymis fat weight	0.2	1.1	1.5	-1.2	1.0	1.1	0.7	1.2
Delta time in closed arm before/after self-admin	0.5	0.5	1.3	-0.7	0.4	0.7	0.2	1.1
Delta time in open arm before/after self-admin	0.3	0.3	0.8	0.5	-0.3	-0.5	-0.1	-0.9
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.4	-0.5	-0.1	-0.5	0.0
Delay discount exponential model param	0.4	0.5	0.7	-0.7	0.4	0.7	0.8	0.9
Extinction: sum of active levers before priming	2.4	3.6	4.9	2.0	-1.7	-1.7	-1.7	-2.2
Active lever presses in extinction session 6	0.5	0.5	0.7	0.8	-0.6	-0.5	-0.8	-0.7
Bone: final force	2.1	3.4	4.0	-2.0	1.8	1.9	1.6	1.9
Bone: final moment	1.7	2.8	3.3	-1.8	1.6	1.7	1.4	1.8
Food consumed during 24 hour testing period	0.8	1.5	1.9	-1.4	1.3	1.2	1.3	1.0
Glucose	2.4	3.8	4.2	-2.0	2.0	2.0	1.8	1.9
Heart weight	0.4	0.6	1.1	-0.7	0.8	1.1	0.6	0.8
Delay discount hyperbolic model param	0.3	0.3	0.5	-0.6	0.3	0.6	0.7	0.7
Intermittent access intake day 1-15 change	0.3	1.5	2.4	-1.3	0.9	1.1	1.1	1.5
Intermittent access intake escalation	0.2	1.2	2.2	-1.1	0.8	1.1	0.9	1.5
Intermittent access intake escalation 2	1.4	2.4	4.4	-1.7	1.0	1.4	1.2	2.1
Intermitt. access day 1 inactive lever presses	0.1	1.6	2.0	-1.4	1.4	1.4	1.0	1.2
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.2	-0.4	0.4	0.4	0.3	0.3
Intermitt. access escalation Index	0.1	0.3	0.6	-0.4	0.6	0.8	0.6	0.5
Intermittent access day 1 total infusions	1.0	3.1	6.3	2.1	-1.0	-1.6	-1.1	-2.5
Intermittent access day 15 total infusions	0.0	0.0	0.1	0.2	0.2	0.1	0.3	-0.2
Intermittent access terminal intake (last 3 days)	0.2	0.4	0.9	-0.4	0.8	0.4	1.0	0.1
Intermittent access total infusions	0.2	0.2	0.4	0.0	0.6	0.0	0.6	-0.5
Intermittent access day 1 locomotion	1.6	2.9	5.0	2.1	-1.1	-1.7	-1.2	-2.2
Intermittent access day 15 total locomotion	0.6	2.2	3.4	1.9	-1.0	-1.5	-1.1	-1.7
Intermittent access total locomotion	1.9	2.3	3.5	1.9	-1.2	-1.6	-1.2	-1.6
Intermittent access standard deviation	0.2	0.8	1.0	-1.0	1.0	0.7	0.9	0.8
Left kidney weight	0.3	2.4	3.5	-1.8	1.5	1.5	1.9	1.0
Right kidney weight	0.2	1.1	1.4	-1.1	0.9	1.2	1.1	0.9
Cocaine induced anxiety	0.0	0.1	0.4	-0.6	0.2	-0.1	0.4	-0.2
Post-drug Anxiety	1.3	1.5	2.6	-1.6	1.3	0.9	1.5	0.6
Baseline Anxiety	0.4	0.7	0.9	-0.9	0.6	1.0	0.8	0.9
Tail length	1.4	7.7	8.4	-2.9	2.8	2.9	2.8	2.6
Length with tail	1.4	6.3	7.7	-2.5	2.8	2.6	2.7	1.9
Length without tail	0.0	0.2	0.4	-0.1	0.6	0.3	0.6	-0.3
Times rat made contact with spout	0.7	0.8	1.6	-1.3	0.6	0.8	0.8	0.8
Lifetime Intake	0.3	0.4	0.7	0.2	0.8	0.0	0.8	-0.8
Liver weight, left	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.1	-0.3
Liver weight, right	0.5	0.9	1.3	1.0	-1.1	-1.0	-0.8	-0.9
Locomotor activity	0.0	0.0	0.1	-0.3	0.1	0.1	0.0	0.0
Locomotor testing distance	0.1	0.2	0.6	-0.0	-0.0	-0.4	-0.2	-0.8
Locomotor testing rearing	0.5	1.9	2.9	-1.7	1.6	1.2	1.4	1.0
Locomotion in novel chamber	0.2	0.3	0.7	0.3	-0.8	-0.5	-0.6	-0.3
Locomotion in novel chamber post-restriction	0.6	1.8	3.3	-1.6	1.0	1.3	0.9	1.8
Fecal boli incidents, locomotor time 1	0.6	1.5	2.4	0.8	-1.4	-1.2	-1.6	-1.0
Change in fecal boli incidents, locomotor task	0.7	0.7	1.3	-0.7	1.1	0.7	0.9	0.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.2	0.5	0.1	0.4	-0.2
Bouts of movement, locomotor time 1	1.3	1.7	2.5	0.1	-1.6	-1.4	-1.5	-1.2
Total resting periods, locomotor time 1	2.0	2.3	3.5	0.4	-1.9	-1.7	-1.8	-1.3
Rest time, locomotor task time 1	1.1	1.8	3.3	1.1	-1.8	-1.2	-1.8	-0.2
Distance moved, locomotor task time 1	0.8	2.3	4.2	-0.9	1.9	1.6	2.1	0.6
Vertical activity count, locomotor time 1	0.2	1.2	2.4	-0.5	1.5	1.1	1.6	-0.1
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	0.2	0.3	0.2	0.2	0.1
Bouts of movement, locomotor time 2	0.4	1.2	3.3	-1.8	0.9	0.7	0.8	0.6
Total resting periods, locomotor time 2	0.1	0.6	2.3	-1.5	0.5	0.3	0.5	0.3
Rest time, locomotor task time 2	0.7	1.3	1.6	1.1	-1.3	-1.1	-1.2	-0.8
Distance moved, locomotor task time 2	0.5	0.6	1.3	-0.1	0.6	1.0	0.7	1.1
Vertical activity count, locomotor time 2	0.2	0.6	0.9	-0.0	0.9	1.0	0.8	0.6
Light reinforcement 1	0.5	2.1	4.0	-1.1	2.0	1.3	1.9	0.4
Light reinforcement 2	0.3	0.7	1.5	-0.3	1.2	0.4	1.2	-0.6
Bone: marrow area	1.2	3.0	3.6	-1.8	1.8	1.7	1.9	1.4
Bone: maximum diameter	2.6	5.3	6.1	-2.5	2.2	2.3	2.0	2.4
Bone: maximum force	3.6	7.1	8.7	-2.9	2.6	2.7	2.3	2.7
Bone: maximum moment	3.0	5.7	7.1	-2.7	2.2	2.4	2.0	2.5
Mean time between licks in bursts	0.1	0.5	0.6	0.6	-0.6	-0.7	-0.8	-0.6
Mean num. licks in bursts	1.3	3.6	3.9	1.9	-2.0	-1.9	-1.9	-1.8
Cd content in liver	1.1	1.2	1.6	-0.9	1.3	1.1	1.2	0.9
Co content in liver	0.4	0.5	0.9	0.8	-0.4	-0.7	-0.3	-1.0
Cu content in liver	1.8	2.2	2.5	1.6	-1.6	-1.5	-1.5	-1.2
Fe content in liver	0.6	0.8	1.7	0.9	-0.7	-0.9	-0.4	-1.3
K content in liver	0.4	0.4	0.8	0.9	-0.3	-0.6	-0.2	-0.8
Mg content in liver	1.2	1.4	2.2	1.5	-1.0	-1.1	-1.0	-1.2
Mn content in liver	1.0	1.1	2.0	-0.8	0.9	1.2	0.9	1.4
Na content in liver	1.3	1.5	1.9	1.4	-1.2	-1.2	-1.1	-1.1
Rb content in liver	5.1	6.0	6.8	2.6	-2.4	-2.5	-2.2	-2.6
Se content in liver	2.5	2.9	3.5	-1.5	1.6	1.8	1.7	1.9
Sr content in liver	0.1	0.1	0.3	0.2	0.5	0.3	0.1	0.4
Zn content in liver	0.0	0.0	0.1	0.1	0.1	0.2	-0.0	0.4
Bone: minimum diameter	0.0	0.0	0.1	0.1	-0.3	-0.1	-0.3	0.1
Time in familiar zone, hab. session 1	0.4	0.4	1.0	0.3	-0.9	-0.5	-1.0	0.2
Time in novel zone, hab. session 1	1.5	1.7	3.3	1.5	-0.8	-1.3	-0.8	-1.8
Total zone transitions, hab. session 1	0.0	0.0	0.1	0.1	0.1	0.0	-0.3	0.1
Total locomotion distance, hab. session 1	0.3	0.4	1.2	-0.5	0.5	0.7	0.1	1.1
Locomotion velocity, hab. session 1	1.5	2.1	3.3	-1.4	1.4	1.5	1.0	1.8
Time in familiar zone, hab. session 2	0.8	0.9	1.6	1.0	-1.0	-0.8	-1.2	-0.3
Time in novel zone, hab. session 2	1.0	1.1	2.6	0.8	-0.9	-1.1	-0.5	-1.6
Total zone transitions, hab. session 2	0.5	0.7	1.1	-0.6	1.0	0.9	1.0	0.6
Total locomotion distance, hab. session 2	0.8	1.0	1.3	-0.8	1.1	1.1	1.0	1.1
Locomotion velocity, hab. session 2	1.0	1.4	1.7	-1.0	1.3	1.3	1.1	1.2
Novel to familiar place preference ratio	3.2	4.1	5.3	2.3	-1.7	-2.1	-1.7	-2.3
Novelty place preference	4.3	5.5	6.6	2.6	-2.1	-2.4	-2.1	-2.6
Time in novel zone, NPP test	5.4	6.6	8.0	2.8	-2.3	-2.6	-2.2	-2.8
Total zone transitions, NPP test	0.6	0.9	1.6	-0.6	1.2	1.0	1.0	0.6
Total locomotion distance, NPP test	1.7	2.3	3.4	-1.2	1.8	1.6	1.6	1.3
Locomotion velocity, NPP test	2.2	3.1	4.2	-1.5	2.1	1.9	1.7	1.6
Intraocular pressure	2.2	3.5	4.4	-1.7	2.1	1.9	2.0	1.6
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.2	-0.2	0.0	0.1	0.2
Delta ambulatory time before/after self-admin	0.2	0.3	0.6	0.4	-0.7	-0.6	-0.4	-0.3
Parametrial fat weight	0.1	0.2	0.3	0.6	-0.1	-0.4	-0.3	-0.4
Pavlov. Cond. lever latency	7.5	9.5	10.6	2.8	-3.2	-3.2	-3.3	-2.9
Pavlov. Cond. magazine entry latency	0.5	0.6	1.0	-0.6	0.9	0.9	0.6	1.0
Pavlov. Cond. change in total contacts	3.0	3.2	3.7	-1.5	1.9	1.9	1.9	1.7
Pavlov. Cond. index score	3.6	4.5	5.2	-1.9	2.2	2.3	2.1	2.2
Pavlov. Cond. latency score	3.2	4.1	4.7	-1.8	2.1	2.2	2.0	2.0
Pavlov. Cond. lever contacts	6.9	8.3	9.3	-2.6	2.9	3.0	3.0	2.8
Pavlov. Cond. magazine entry number	0.7	0.9	1.5	0.8	-1.0	-1.1	-0.7	-1.2
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.7	-0.8	0.4	0.5	0.5	0.6
Pavlov. Cond. lever-magazine prob. diff.	3.5	4.4	5.0	-1.9	2.1	2.2	2.0	2.2
Pavlov. Cond. response bias	4.4	5.5	6.1	-2.2	2.4	2.5	2.2	2.4
Pavlov. Cond. lever latency	2.6	3.6	4.9	2.0	-1.7	-2.0	-1.5	-2.2
Pavlov. Cond. magazine entry latency	0.1	0.2	0.3	0.4	-0.5	-0.4	-0.5	-0.2
Pavlov. Cond. change in total contacts	0.5	1.1	2.8	-1.0	0.7	1.1	0.4	1.7
Pavlov. Cond. index score	0.2	0.4	1.0	-0.6	0.3	0.6	0.2	1.0
Pavlov. Cond. latency score	0.3	0.5	1.2	-0.8	0.4	0.7	0.3	1.1
Pavlov. Cond. lever contacts	1.8	2.6	3.8	-1.7	1.4	1.7	1.3	1.9
Pavlov. Cond. magazine entry number	0.2	0.3	0.8	0.5	-0.1	-0.4	-0.1	-0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.3	0.4	-0.5	0.6	0.5	0.6	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.4	1.0	-0.6	0.3	0.6	0.2	1.0
Pavlov. Cond. response bias	0.9	1.3	2.4	-1.2	0.9	1.2	0.7	1.6
Time in closed arm before self-admin	0.3	0.5	0.7	0.6	-0.8	-0.8	-0.8	-0.7
Time in closed arm after self-admin	0.1	0.2	0.4	-0.1	-0.6	-0.2	-0.5	0.3
Time in open arm before self-admin	1.0	1.2	2.2	-1.0	1.5	1.1	1.1	0.7
Time in open arm after self-admin	0.6	0.7	1.4	-0.6	1.2	0.7	1.0	0.2
Bone: periosteal estimation	2.0	4.6	5.5	-2.4	2.1	2.1	2.1	2.1
Bone: periosteal perimeter	0.6	1.3	1.6	-1.2	1.2	1.1	1.2	0.9
Bone: post-yield work	2.0	3.5	4.4	-1.8	2.1	1.9	1.9	1.5
Progressive ratio test 1 active lever presses	0.3	0.6	1.8	0.9	0.1	-0.6	0.4	-1.3
Progressive ratio test 1 breakpoint	0.3	0.5	1.3	0.7	0.3	-0.5	0.5	-1.2
Progressive ratio test 1 inactive lever presses	0.4	1.0	2.0	-0.6	1.4	0.8	1.3	-0.1
Progressive ratio test 2 active lever presses	0.7	1.0	2.9	1.1	0.0	-0.9	0.2	-1.7
Progressive ratio test 2 breakpoint	0.8	1.1	3.2	1.1	-0.0	-0.9	0.1	-1.8
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.6	-0.2	0.8	0.3	0.6	-0.0
Incentive Sensitization - Responses	0.1	0.2	0.5	0.1	0.3	-0.3	0.7	-0.7
Incentive Sensitization - Breakpoint	0.1	0.2	0.7	0.2	0.2	-0.4	0.5	-0.8
Sum of active levers in priming session hrs 5-6	3.6	3.4	5.0	1.9	-1.5	-1.8	-1.7	-2.2
Progressive ratio	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.1	-0.1
Food seeking constrained by brief footshock	8.4	10.5	15.0	-3.4	3.5	3.0	3.9	2.2
Seeking ratio, punishment vs. effort	1.5	3.4	4.6	-1.8	2.0	1.7	2.2	1.4
Retroperitoneal fat weight	0.4	1.6	2.6	1.3	-1.2	-1.3	-1.6	-0.7
Reaction time number correct	0.0	0.1	0.3	0.2	0.5	0.1	0.1	-0.1
Reaction time mean minus median	0.1	0.8	1.6	-1.3	-0.1	0.8	-0.2	1.2
Reaction time mean minus median AUC	0.2	1.3	2.6	-1.6	0.4	1.1	0.4	1.5
Reaction time num false alarms	0.1	0.1	0.3	-0.6	-0.1	0.0	-0.0	0.4
Reaction time num false alarms AUC	0.3	0.7	1.7	-1.3	0.6	0.6	0.6	0.7
Reaction time trials correct on left	0.0	0.1	0.3	0.2	0.5	0.1	0.1	-0.1
Reaction time trials on left	0.0	0.0	0.2	0.2	0.4	0.0	-0.0	-0.1
Reaction time mean	0.6	1.4	3.0	0.4	-1.7	-1.0	-1.6	-0.5
Reaction time mean AUC	0.7	1.7	3.7	0.6	-1.9	-1.1	-1.7	-0.6
Median of all reaction times	1.9	3.0	4.9	1.3	-2.2	-1.7	-2.0	-1.3
Reaction time omissions	1.5	2.5	4.0	0.7	-1.8	-1.6	-2.0	-1.5
Reaction time false alarm rate	0.1	0.1	0.4	-0.7	-0.3	-0.0	-0.1	0.2
Reaction time premature initiation rate	2.0	3.1	4.4	1.7	-1.9	-1.7	-2.1	-1.2
Reaction time premature initiations	0.8	2.3	3.5	1.6	-1.5	-1.4	-1.9	-1.2
Std. dev. reaction times	0.1	0.4	0.9	-0.5	-0.8	-0.0	-0.9	0.5
Reaction time trials completed	0.0	0.0	0.2	0.2	0.4	0.0	-0.0	-0.1
Reaction time trials AUC	0.0	0.0	0.1	0.3	0.4	0.0	-0.1	-0.1
Run reversals in cocaine runway, females	0.1	0.1	0.2	0.4	-0.5	-0.3	-0.4	-0.1
Run reversals in cocaine runway, males	0.1	0.1	0.1	0.2	-0.3	-0.3	-0.2	-0.2
Latency to leave start box in cocaine runway	0.7	1.0	1.4	-1.0	1.0	0.9	0.8	1.2
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	0.4	0.0	-0.3	-0.2	-0.2
Latency to leave start box in cocaine runway, M	3.1	3.0	3.3	-1.8	1.7	1.8	1.8	1.6
Std. dev. time between licks in bursts	0.2	0.4	0.5	0.6	-0.7	-0.7	-0.7	-0.6
Total sessions with >9 infusions	0.5	0.6	1.3	0.2	1.0	0.2	1.1	-0.8
Short access day 1 total inactive lever presses	0.8	1.6	2.8	-1.2	1.7	1.0	1.6	0.3
Short access day 10 total inactive lever presses	0.3	1.8	2.6	-1.6	1.2	1.2	0.9	1.6
Short access day 1 total infusions	0.4	0.7	1.6	-0.1	1.2	0.4	1.2	-0.5
Short access day 10 total infusions	0.2	0.4	1.1	0.5	0.6	-0.2	0.4	-1.1
Short access total infusions	0.4	0.6	1.7	0.6	0.7	-0.3	0.7	-1.3
Short access day 1 locomotion	1.2	2.0	3.6	1.9	-0.6	-1.3	-1.1	-1.7
Short access day 10 total locomotion	0.3	1.3	2.2	1.5	-1.0	-1.2	-1.2	-0.7
Short access total locomotion	0.6	0.9	2.0	1.4	-0.2	-0.8	-0.6	-1.1
One hour access (0.3 mA shock)	0.2	0.2	0.5	0.3	0.4	0.0	0.7	-0.7
Compulsive drug intake	0.1	0.1	0.4	-0.2	-0.0	0.2	-0.1	0.6
One hour access (shock baseline)	0.1	0.4	1.0	0.2	0.5	-0.1	0.7	-1.0
Social response proportion	1.8	2.3	3.7	1.5	-1.6	-1.5	-1.9	-0.9
Social responses	0.7	0.9	1.2	-0.7	1.1	0.9	0.8	1.1
Social time	0.0	0.0	0.0	-0.1	0.0	-0.0	-0.0	-0.0
Soleus weight	0.1	0.2	0.6	-0.2	0.6	0.1	0.4	-0.7
Bone: stiffness	4.8	8.7	10.0	-3.2	2.8	3.0	2.7	3.0
Tibialis anterior weight	9.0	30.9	33.5	-5.8	5.8	5.6	5.6	5.0
Time to tail flick, vehicle, before self-admin	1.1	1.3	2.1	1.1	-1.4	-1.1	-1.3	-0.6
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	0.1	0.1	0.1	0.1	0.3
Time to tail flick, test, before self-admin	0.5	0.6	0.9	-0.9	0.7	0.6	0.9	0.7
Time to tail flick, test, after self-admin	1.6	1.6	3.6	-1.3	1.0	1.3	0.6	1.9
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	0.9	-0.9	1.0	0.7	0.8	0.6
Delta time to tail flick, test, before/after SA	0.1	0.1	0.5	0.2	-0.4	-0.1	-0.7	0.2
Tibia length	0.1	0.2	0.4	0.2	0.6	0.1	0.6	-0.3
Ambulatory time before self-admin	1.7	5.1	6.9	-2.3	2.6	2.3	2.5	1.5
Ambulatory time after self-admin	1.0	1.7	2.2	-1.4	1.4	1.2	1.5	1.0
Bone: tissue strength	0.3	0.3	0.4	-0.6	0.6	0.5	0.3	0.5
Total heroin consumption	1.5	1.7	3.3	1.7	-0.7	-1.1	-0.9	-1.8
Bone: trabecular number	0.9	1.7	2.7	-1.6	1.0	1.3	0.8	1.5
Bone: trabecular spacing	0.0	0.0	0.1	-0.1	0.1	0.1	0.0	0.3
Bone: trabecular thickness	0.2	0.3	0.4	0.6	-0.6	-0.5	-0.6	-0.3
Bone: trabecular tissue density	3.1	5.4	6.0	-2.0	2.5	2.4	2.4	2.2
Water consumed over 24 hours	0.9	1.7	2.7	-1.6	1.2	1.2	1.3	1.2
Number of responses in last shaping day	0.4	0.5	1.8	0.5	0.7	-0.3	0.3	-1.3