Hub : Genes

Ccl21

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Ccl21	0.11	0.06	5.4e-14	0.14	0.14	0.14	0.14	1.3e-15	3.5e-15	7.0e-15	7.9e-15
2	Liver	gene expression	Ccl21	0.09	0.06	1.3e-09	0.07	0.08	0.07	0.07	1.4e-08	7.5e-09	1.3e-08	1.2e-08
3	IL	gene expression	Ccl21	0.28	0.15	1.1e-05	0.19	0.19	0.19	0.19	3.0e-05	2.9e-05	3.1e-05	2.0e-05
4	Brain	gene expression	Ccl21	0.05	0.04	3.6e-04	0.03	0.01	0.04	0.03	1.2e-03	1.3e-02	3.2e-04	1.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.4	2.3	3.7	1.4	1.4	-1.3	1.9
Area under the delay curve	0.5	0.5	1.0	-0.5	-0.6	0.7	1.0
BMI with tail	1.7	5.6	7.0	2.6	2.6	-2.2	2.1
BMI without tail	6.0	12.5	14.2	3.6	3.8	-3.2	3.5
Body weight	3.8	16.1	20.5	3.9	4.0	-3.5	4.5
Weight adjusted by age	0.5	0.6	1.7	0.3	0.3	-0.6	1.3
Bone surface	1.4	2.5	5.6	1.2	1.2	-1.2	2.4
Bone volume	1.2	2.1	4.3	1.1	1.1	-1.2	2.1
Breakpoint value in progressive ratio session	0.9	0.9	3.4	-0.3	-0.4	0.3	1.9
Number of licking bursts	4.7	5.6	7.3	2.7	2.7	-2.7	0.8
Context. condit. distance diff. score	0.2	0.3	0.7	-0.4	-0.4	0.3	-0.8
Locomotion velocity, session 1	2.1	2.3	5.8	1.1	1.0	-1.1	2.4
Locomotion distance, session 1	0.8	1.0	2.1	0.9	0.8	-0.8	1.4
Locomotion velocity, session 2	2.0	2.3	2.5	1.5	1.6	-1.6	1.5
Locomotion distance, session 2	2.8	3.9	4.3	2.1	2.0	-2.1	1.8
Locomotion velocity, session 3	0.4	0.5	1.5	0.5	0.4	-0.4	1.2
Locomotion distance, session 3	2.3	2.5	3.4	1.8	1.8	-1.5	1.2
Stereotopy head waving bouts, day 3	0.1	0.1	0.4	-0.1	0.0	-0.6	-0.0
Stereotopy head waving duration, day 3	0.1	0.1	0.3	-0.6	-0.4	-0.3	-0.0
Locomotion velocity, session 7	0.2	0.2	0.9	-0.1	-0.2	-0.1	0.9
Locomotion distance, session 7	0.3	0.4	0.5	0.7	0.6	-0.5	0.7
Stereotopy head waving bouts, day 7	2.6	3.0	4.8	1.7	1.8	-2.2	1.0
Stereotopy head waving duration, day 7	1.1	1.3	2.4	0.9	1.0	-1.5	1.1
Locomotion velocity, session 8	0.3	0.3	0.5	0.4	0.3	-0.7	0.7
Locomotion distance, session 8	0.3	0.5	0.6	0.8	0.6	-0.7	0.6
Degree of sensitization distance	0.8	0.8	1.2	-1.1	-1.1	0.8	-0.4
Degree of sensitization stereotypy	1.4	1.6	2.5	1.2	1.3	-1.6	0.8
Conditioned locomotion	0.3	0.3	1.2	0.1	0.0	-0.2	-1.1
Cocaine response after cond. corrected	0.7	0.8	1.2	-1.0	-1.1	0.9	0.3
Cocaine response after cond. not corrected	0.5	0.5	0.7	-0.7	-0.9	0.6	0.8
Cocaine response before conditioning	1.1	1.3	1.9	1.1	1.1	-1.4	1.0
Saline control response	1.7	2.2	3.1	1.4	1.4	-1.8	1.2
Bone: connectivity density	0.7	1.2	2.8	0.8	0.8	-0.7	1.7
Bone: cortical apparent density	0.1	0.1	0.2	-0.4	-0.3	0.3	-0.4
Bone: cortical area	2.4	3.5	4.3	1.9	1.9	-1.7	2.1
Bone: cortical porosity	1.0	1.1	1.5	-0.8	-0.8	1.2	-1.2
Bone: cortical porosity	0.1	0.1	0.2	-0.1	-0.1	0.5	-0.4
Bone: cortical thickness	0.5	0.9	1.2	0.9	1.0	-0.7	1.1
Bone: cortical thickness	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.3
Bone: cortical tissue density	0.1	0.2	0.2	-0.5	-0.4	0.3	-0.5
Condit. Reinf. active minus inactive responses	0.5	0.5	0.7	0.8	0.7	-0.5	0.9
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.0	-0.9	-0.9	1.0	-0.3
Condit. Reinf. active responses	2.6	3.2	3.6	1.9	1.9	-1.8	1.5
Condit. Reinf. inactive responses	3.0	3.5	4.3	2.0	2.0	-2.1	1.4
Incentive salience index mean	4.4	5.4	6.2	2.5	2.4	-2.2	2.1
Condit. Reinf. lever presses	11.4	15.2	17.1	4.1	4.1	-3.9	3.4
Condit. Reinf. active minus inactive responses	0.6	0.8	1.0	1.0	0.9	-0.8	0.9
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.2	0.2	-0.0	0.4
Condit. Reinf. active responses	2.5	3.5	3.9	2.0	1.9	-1.7	1.9
Condit. Reinf. inactive responses	2.9	3.5	4.3	2.0	2.1	-1.8	1.5
Condit. Reinf. lever presses	2.3	3.1	4.1	1.6	1.7	-1.6	2.0
Condit. Reinf. lever reinforcers received	2.9	4.1	4.4	2.1	2.0	-1.9	2.1
Conditioned reinforcement - actives	1.3	1.3	3.5	1.1	0.5	-0.6	-1.9
Conditioned reinforcement - inactives	1.8	2.0	7.2	0.5	0.2	-0.6	-2.7
Conditioned locomotion	0.6	0.7	1.7	1.3	0.7	-0.7	0.0
Patch foraging indifference point 0 sec	0.6	0.9	1.2	1.1	0.8	-1.0	0.9
Patch foraging indifference point AUC	7.2	8.3	9.8	3.1	3.1	-2.5	2.7
Delay disc. indifference point, 0s delay	0.8	0.9	1.2	-1.1	-1.1	1.0	-0.4
Delay disc. indifference point, 16s delay	0.4	0.4	0.6	-0.6	-0.8	0.7	-0.2
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	-0.0	0.0	-0.1	-0.2
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	-0.3	-0.4	0.6	0.1
Delay disc. indifference point, 4s delay	0.4	0.4	1.2	-0.2	-0.3	0.5	1.1
Delay disc. indifference point, 8s delay	0.8	0.9	3.4	0.1	0.0	0.1	1.9
Indifference point function ln k	1.8	2.5	3.5	-1.8	-1.9	1.4	-1.2
Indifference point function log k	1.8	2.5	3.5	-1.8	-1.9	1.4	-1.2
Patch foraging total patch changes 0 sec	1.0	1.6	2.1	1.4	1.2	-1.3	1.1
Patch foraging total patch changes 12 sec	1.5	1.9	3.1	1.8	1.7	-1.2	0.5
Patch foraging total patch changes 18 sec	0.9	1.2	1.8	1.2	1.0	-0.8	1.3
Patch foraging total patch changes 24 sec	2.3	2.8	3.4	1.8	1.8	-1.5	1.5
Patch foraging total patch changes 6 sec	3.0	4.5	5.5	2.4	2.1	-2.0	2.0
Patch foraging time to switch 0 sec	2.7	4.1	4.5	-2.1	-2.1	2.0	-1.9
Patch foraging water rate 0 sec	1.5	2.4	3.0	1.7	1.7	-1.5	1.2
Patch foraging water rate 12 sec	0.2	0.4	1.1	0.3	0.2	-0.4	1.0
Patch foraging water rate 18 sec	0.1	0.1	0.3	0.4	0.5	-0.3	-0.2
Patch foraging water rate 24 sec	0.1	0.2	0.3	-0.5	-0.3	0.3	-0.5
Patch foraging water rate 6 sec	1.1	1.6	1.9	1.3	1.3	-1.4	1.1
Seeking ratio, delayed vs. immediate footshock	3.2	3.7	4.4	2.0	2.1	-2.0	1.5
Distance traveled before self-admin	7.4	7.9	9.9	2.9	2.8	-3.2	2.2
Distance traveled after self-admin	1.3	1.5	2.6	1.3	1.3	-1.6	0.2
Extensor digitorum longus weight	5.9	23.1	24.7	4.8	4.7	-5.0	4.8
Bone: elastic displacement	5.5	6.2	8.0	-2.6	-2.6	2.8	-1.7
Bone: elastic work	2.5	3.2	4.3	-1.9	-1.9	2.1	-1.1
Bone: endosteal estimation	1.8	3.8	4.9	1.7	1.7	-2.1	2.2
Bone: endosteal perimeter	1.7	3.5	4.5	1.8	1.7	-2.1	1.8
Epididymis fat weight	1.3	3.0	6.6	1.4	1.3	-1.2	2.6
Delta time in closed arm before/after self-admin	1.3	1.3	1.7	1.1	1.3	-0.9	1.2
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.3	-0.5	0.3	-0.1
Diff in mean of infusions in LGA sessions	0.5	0.5	1.6	-0.6	-0.3	0.1	1.3
Delay discount exponential model param	0.5	0.5	1.2	0.4	0.6	-0.7	-1.1
Extinction: sum of active levers before priming	1.7	1.6	1.8	-1.3	-1.3	1.3	-1.2
Active lever presses in extinction session 6	1.1	1.0	2.0	-0.9	-1.0	1.4	0.6
Bone: final force	2.0	3.2	4.7	1.6	1.6	-1.7	2.2
Bone: final moment	1.5	2.5	4.2	1.3	1.3	-1.5	2.1
Food consumed during 24 hour testing period	1.0	1.2	1.8	1.3	1.3	-1.0	0.5
Glucose	1.0	1.5	1.9	1.4	1.4	-1.0	1.2
Heart weight	1.5	2.1	5.1	1.2	1.1	-0.8	2.3
Delay discount hyperbolic model param	0.5	0.5	1.4	0.3	0.5	-0.6	-1.2
Intermittent access intake day 1-15 change	0.3	0.3	0.6	0.7	0.8	-0.6	-0.1
Intermittent access intake escalation	0.6	0.6	1.0	0.9	1.0	-0.8	0.0
Intermittent access intake escalation 2	0.8	0.8	1.1	0.9	1.0	-1.0	-0.7
Intermitt. access day 1 inactive lever presses	0.6	0.6	0.9	0.9	0.9	-0.8	0.4
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.3	0.4	0.5	-0.6	-0.2
Intermitt. access escalation Index	1.8	1.6	2.1	1.1	1.2	-1.2	1.5
Intermittent access day 1 total infusions	0.2	0.2	0.4	-0.3	-0.6	0.6	-0.2
Intermittent access day 15 total infusions	0.4	0.4	0.8	0.9	0.7	-0.6	-0.2
Intermittent access terminal intake (last 3 days)	1.1	1.3	1.9	1.4	1.0	-1.2	-0.9
Intermittent access total infusions	0.7	0.8	1.6	1.3	0.9	-0.9	-0.1
Intermittent access day 1 locomotion	1.1	1.1	1.8	-1.0	-1.2	1.4	-0.6
Intermittent access day 15 total locomotion	0.7	0.8	1.3	-0.7	-1.0	1.2	-0.5
Intermittent access total locomotion	0.8	0.9	1.2	-0.7	-0.9	1.1	-1.0
Intermittent access standard deviation	0.5	0.6	0.7	0.9	0.7	-0.6	-0.8
Left kidney weight	0.5	1.4	1.9	1.4	1.4	-1.2	0.6
Right kidney weight	0.1	0.2	0.3	0.3	0.4	-0.4	0.5
Cocaine induced anxiety	1.0	1.2	2.6	-0.8	-1.0	0.7	-1.6
Post-drug Anxiety	0.5	0.6	0.8	0.9	0.8	-0.9	0.1
Baseline Anxiety	0.8	0.9	1.1	0.8	1.0	-0.7	1.1
Tail length	3.6	10.9	16.0	3.0	3.2	-2.9	4.0
Length with tail	1.6	6.0	12.4	2.0	2.1	-1.9	3.5
Length without tail	0.3	0.6	0.8	-0.9	-0.9	0.7	0.3
Times rat made contact with spout	0.4	0.5	0.9	0.6	0.7	-1.0	0.4
Lifetime Intake	1.2	1.3	2.5	1.6	1.1	-1.3	-0.0
Liver weight, left	0.4	0.6	1.1	1.0	1.0	-0.7	-0.3
Liver weight, right	0.1	0.1	0.5	-0.1	-0.1	-0.1	0.7
Locomotor activity	0.0	0.1	0.2	0.2	0.2	0.2	0.4
Locomotor testing distance	0.1	0.2	0.8	0.3	0.2	0.1	0.9
Locomotor testing rearing	1.3	2.0	3.0	1.7	1.4	-1.4	1.1
Locomotion in novel chamber	0.6	0.7	2.1	-0.4	-0.4	0.5	-1.5
Locomotion in novel chamber post-restriction	0.8	1.0	1.3	1.1	1.1	-1.1	0.5
Fecal boli incidents, locomotor time 1	1.2	1.4	1.9	-1.4	-1.2	1.4	-0.4
Change in fecal boli incidents, locomotor task	2.5	2.4	4.3	1.5	1.2	-1.3	2.1
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.3	0.3	0.3	-0.3	1.2
Bouts of movement, locomotor time 1	1.6	1.8	2.2	-1.5	-1.4	1.3	-1.1
Total resting periods, locomotor time 1	2.3	2.6	3.3	-1.8	-1.7	1.6	-1.2
Rest time, locomotor task time 1	3.2	3.6	5.1	-1.9	-1.6	1.8	-2.3
Distance moved, locomotor task time 1	2.9	3.1	3.7	1.9	1.8	-1.9	1.4
Vertical activity count, locomotor time 1	1.8	1.9	2.1	1.4	1.4	-1.4	1.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	0.3	0.3	-0.2	-0.2
Bouts of movement, locomotor time 2	1.2	1.2	2.4	0.9	0.9	-1.0	1.6
Total resting periods, locomotor time 2	0.5	0.6	1.3	0.5	0.5	-0.7	1.1
Rest time, locomotor task time 2	1.0	1.1	1.5	-1.2	-1.1	0.9	-1.0
Distance moved, locomotor task time 2	0.2	0.3	0.5	0.5	0.7	-0.4	-0.3
Vertical activity count, locomotor time 2	0.4	0.5	0.8	0.7	0.9	-0.6	0.6
Light reinforcement 1	2.1	3.8	4.9	2.2	2.0	-1.8	1.9
Light reinforcement 2	0.8	1.0	1.7	1.3	1.0	-1.1	0.5
Bone: marrow area	1.8	4.0	5.2	1.7	1.7	-2.2	2.3
Bone: maximum diameter	2.7	4.9	5.2	2.2	2.2	-2.3	2.2
Bone: maximum force	3.4	5.9	6.6	2.4	2.4	-2.6	2.3
Bone: maximum moment	2.6	4.6	5.0	2.0	2.1	-2.2	2.2
Mean time between licks in bursts	0.2	0.3	0.5	-0.6	-0.7	0.4	0.6
Mean num. licks in bursts	2.3	2.7	4.0	-2.0	-1.9	1.7	-0.5
Cd content in liver	0.7	0.7	1.5	0.8	0.9	-1.2	-0.1
Co content in liver	1.2	1.4	3.1	-1.0	-1.0	0.8	-1.8
Cu content in liver	2.0	2.4	5.8	-1.3	-1.1	0.9	-2.4
Fe content in liver	0.6	0.7	1.3	0.7	0.6	-1.1	0.7
K content in liver	0.3	0.3	0.4	-0.4	-0.4	0.6	-0.6
Mg content in liver	0.8	0.8	1.3	-0.9	-0.9	1.1	-0.6
Mn content in liver	0.1	0.1	0.1	0.2	0.3	-0.3	-0.1
Na content in liver	1.9	2.0	3.9	-1.2	-1.1	1.1	-2.0
Rb content in liver	3.1	3.9	5.4	-2.3	-2.3	2.1	-0.7
Se content in liver	1.1	1.4	2.3	1.4	1.5	-1.2	-0.1
Sr content in liver	0.5	0.5	0.7	0.7	0.6	-0.6	0.9
Zn content in liver	0.1	0.1	0.3	-0.0	-0.0	0.1	-0.5
Bone: minimum diameter	0.1	0.2	0.7	-0.3	-0.3	0.1	0.8
Time in familiar zone, hab. session 1	0.9	0.9	1.2	-0.9	-0.8	0.8	-1.1
Time in novel zone, hab. session 1	0.4	0.4	0.8	-0.8	-0.9	0.1	0.1
Total zone transitions, hab. session 1	0.0	0.0	0.1	0.1	-0.0	0.3	0.2
Total locomotion distance, hab. session 1	0.1	0.2	0.4	0.4	0.4	0.2	-0.6
Locomotion velocity, hab. session 1	0.7	0.9	1.7	1.3	1.3	-0.5	0.0
Time in familiar zone, hab. session 2	0.8	0.9	1.2	-1.1	-1.0	0.9	-0.7
Time in novel zone, hab. session 2	0.4	0.4	0.7	-0.8	-0.9	0.3	-0.3
Total zone transitions, hab. session 2	0.5	0.6	1.0	1.0	0.9	-0.7	0.3
Total locomotion distance, hab. session 2	0.5	0.7	1.1	1.1	1.0	-0.7	-0.2
Locomotion velocity, hab. session 2	0.7	0.9	1.5	1.2	1.2	-0.8	-0.2
Novel to familiar place preference ratio	1.9	2.0	3.1	-1.7	-1.8	1.3	-0.3
Novelty place preference	3.0	3.0	4.5	-2.1	-2.1	1.7	-0.6
Time in novel zone, NPP test	3.7	3.8	5.5	-2.3	-2.3	1.9	-0.9
Total zone transitions, NPP test	0.8	1.2	1.6	1.2	1.1	-0.9	1.0
Total locomotion distance, NPP test	1.5	2.1	3.5	1.9	1.7	-1.2	0.6
Locomotion velocity, NPP test	2.0	2.8	4.4	2.1	2.0	-1.3	1.1
Intraocular pressure	2.2	3.1	4.1	2.0	2.0	-1.8	1.1
Delta distance traveled before/after self-admin	0.9	0.9	2.6	-0.7	-0.7	0.6	-1.6
Delta ambulatory time before/after self-admin	1.7	1.8	3.2	-1.2	-1.2	1.1	-1.8
Parametrial fat weight	0.2	0.3	0.6	0.7	0.8	-0.4	0.1
Pavlov. Cond. lever latency	8.4	10.6	11.8	-3.4	-3.4	3.4	-2.8
Pavlov. Cond. magazine entry latency	0.8	1.1	2.4	0.8	0.7	-0.8	1.6
Pavlov. Cond. change in total contacts	2.9	3.1	3.7	1.9	1.9	-1.7	1.6
Pavlov. Cond. index score	3.5	4.5	4.8	2.2	2.2	-2.2	1.9
Pavlov. Cond. latency score	3.3	4.2	4.5	2.1	2.1	-2.1	1.8
Pavlov. Cond. lever contacts	5.8	6.9	7.8	2.7	2.8	-2.8	2.2
Pavlov. Cond. magazine entry number	1.0	1.2	1.9	-1.1	-1.1	0.8	-1.4
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.5	0.5	-0.3	-0.1
Pavlov. Cond. lever-magazine prob. diff.	3.0	3.7	4.0	2.0	2.0	-2.0	1.7
Pavlov. Cond. response bias	3.9	4.8	5.4	2.2	2.1	-2.1	2.3
Pavlov. Cond. lever latency	2.3	3.1	4.6	-1.7	-1.8	2.1	-1.2
Pavlov. Cond. magazine entry latency	0.3	0.4	0.9	-0.6	-0.6	0.0	0.9
Pavlov. Cond. change in total contacts	0.8	1.2	3.0	0.6	0.7	-0.9	1.7
Pavlov. Cond. index score	0.4	0.5	1.4	0.2	0.3	-0.8	1.2
Pavlov. Cond. latency score	0.5	0.6	1.2	0.3	0.4	-0.9	1.1
Pavlov. Cond. lever contacts	1.3	1.8	2.7	1.2	1.3	-1.6	1.3
Pavlov. Cond. magazine entry number	0.4	0.5	1.9	0.1	-0.0	0.5	-1.4
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.6	0.8	0.7	-0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	1.6	0.2	0.3	-0.8	1.3
Pavlov. Cond. response bias	0.9	1.3	2.8	0.7	0.8	-1.1	1.7
Time in closed arm before self-admin	3.9	4.4	5.1	-1.8	-2.0	2.3	-2.3
Time in closed arm after self-admin	0.5	0.5	0.8	-0.5	-0.6	0.8	-0.9
Time in open arm before self-admin	4.3	4.6	6.4	2.0	1.9	-2.2	2.5
Time in open arm after self-admin	2.0	2.2	2.6	1.4	1.3	-1.6	1.6
Bone: periosteal estimation	2.3	4.8	6.4	2.0	2.0	-2.2	2.5
Bone: periosteal perimeter	1.0	1.7	2.2	1.2	1.1	-1.4	1.5
Bone: post-yield work	2.3	3.1	3.7	1.6	1.6	-1.9	1.9
Progressive ratio test 1 active lever presses	0.5	0.5	0.8	0.9	0.6	-0.9	-0.3
Progressive ratio test 1 breakpoint	0.7	0.7	1.2	1.1	0.8	-1.1	-0.1
Progressive ratio test 1 inactive lever presses	1.1	1.2	1.9	1.3	1.1	-1.4	0.1
Progressive ratio test 2 active lever presses	0.5	0.5	1.1	0.8	0.3	-0.6	-1.0
Progressive ratio test 2 breakpoint	0.3	0.4	1.1	0.5	0.0	-0.3	-1.0
Progressive ratio test 2 inactive lever presses	0.7	0.8	1.5	1.2	0.7	-0.9	-0.5
Incentive Sensitization - Responses	0.8	0.8	2.4	0.7	0.3	-0.6	-1.5
Incentive Sensitization - Breakpoint	0.7	0.7	2.4	0.5	0.2	-0.4	-1.6
Sum of active levers in priming session hrs 5-6	2.9	2.8	3.7	-1.7	-1.9	1.8	-1.1
Progressive ratio	0.1	0.1	0.3	-0.3	-0.2	0.3	-0.6
Food seeking constrained by brief footshock	8.1	10.0	13.1	3.6	3.4	-3.6	1.4
Seeking ratio, punishment vs. effort	2.6	3.2	4.5	2.0	1.8	-2.1	0.9
Retroperitoneal fat weight	0.1	0.4	0.8	-0.5	-0.5	0.9	0.5
Reaction time number correct	0.2	0.3	0.7	0.5	0.3	-0.2	0.9
Reaction time mean minus median	0.1	0.1	0.3	-0.2	0.3	-0.0	0.5
Reaction time mean minus median AUC	0.3	0.4	0.6	0.4	0.8	-0.5	0.6
Reaction time num false alarms	0.0	0.0	0.1	-0.2	-0.0	0.1	-0.2
Reaction time num false alarms AUC	0.2	0.3	0.4	0.5	0.6	-0.6	0.1
Reaction time trials correct on left	0.2	0.3	0.7	0.5	0.3	-0.2	0.9
Reaction time trials on left	0.1	0.2	0.6	0.3	0.2	-0.1	0.8
Reaction time mean	1.1	1.5	2.8	-1.7	-1.4	1.1	-0.4
Reaction time mean AUC	1.4	1.9	3.5	-1.9	-1.6	1.1	-0.6
Median of all reaction times	2.0	2.8	4.5	-2.1	-2.0	1.4	-0.7
Reaction time omissions	1.0	1.4	2.5	-1.6	-1.4	0.9	-0.4
Reaction time false alarm rate	0.1	0.1	0.4	-0.4	-0.2	0.1	-0.6
Reaction time premature initiation rate	2.5	3.4	4.4	-2.0	-1.8	2.1	-1.3
Reaction time premature initiations	1.5	2.2	3.4	-1.6	-1.5	1.8	-0.8
Std. dev. reaction times	0.2	0.3	0.7	-0.8	-0.5	0.5	0.1
Reaction time trials completed	0.1	0.2	0.6	0.3	0.2	-0.1	0.8
Reaction time trials AUC	0.2	0.2	0.7	0.3	0.2	-0.0	0.9
Run reversals in cocaine runway, females	0.2	0.2	0.4	-0.4	-0.2	0.6	-0.6
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.3	-0.2	0.1	-0.4
Latency to leave start box in cocaine runway	1.1	1.2	1.8	1.0	1.0	-1.1	1.3
Latency to leave start box in cocaine runway, F	0.2	0.2	0.9	-0.0	-0.0	-0.1	1.0
Latency to leave start box in cocaine runway, M	2.6	2.5	3.2	1.5	1.5	-1.8	1.5
Std. dev. time between licks in bursts	0.9	1.1	2.7	-0.7	-0.8	0.7	-1.6
Total sessions with >9 infusions	0.3	0.3	0.7	0.9	0.4	-0.7	0.0
Short access day 1 total inactive lever presses	2.9	3.3	5.1	2.3	1.9	-2.1	0.2
Short access day 10 total inactive lever presses	0.3	0.4	0.5	0.6	0.7	-0.7	-0.3
Short access day 1 total infusions	2.9	3.1	5.0	2.2	1.6	-2.1	0.3
Short access day 10 total infusions	1.2	1.3	2.1	1.4	0.9	-0.9	1.2
Short access total infusions	1.0	1.1	2.2	1.5	0.9	-1.2	0.2
Short access day 1 locomotion	0.3	0.3	0.9	0.1	-0.2	0.3	1.0
Short access day 10 total locomotion	1.3	1.5	2.0	-1.1	-1.1	1.4	-1.2
Short access total locomotion	0.4	0.4	1.4	0.4	0.2	0.0	1.2
One hour access (0.3 mA shock)	0.5	0.6	0.7	0.8	0.6	-0.9	-0.7
Compulsive drug intake	0.1	0.1	0.1	0.3	0.3	-0.2	0.3
One hour access (shock baseline)	0.4	0.5	0.8	0.9	0.6	-0.8	-0.2
Social response proportion	4.1	4.4	7.9	-1.5	-1.7	2.2	-2.8
Social responses	0.4	0.5	0.8	0.9	0.9	-0.5	-0.1
Social time	0.2	0.3	1.0	-0.1	-0.1	-0.1	-1.0
Soleus weight	0.3	1.0	3.5	0.5	0.3	-0.4	1.9
Bone: stiffness	4.4	7.0	7.8	2.7	2.7	-2.8	2.4
Tibialis anterior weight	9.7	33.3	37.0	5.7	5.5	-6.1	5.8
Time to tail flick, vehicle, before self-admin	1.9	2.0	2.8	-1.7	-1.5	1.5	-0.5
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.5	0.2	0.1	-0.2	0.7
Time to tail flick, test, before self-admin	0.5	0.5	1.3	0.5	0.4	-0.6	-1.1
Time to tail flick, test, after self-admin	0.3	0.3	0.8	0.6	0.4	0.0	0.9
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.8	0.9	0.8	-0.8	0.1
Delta time to tail flick, test, before/after SA	0.4	0.4	0.6	-0.4	-0.3	0.7	0.8
Tibia length	0.3	0.9	2.9	0.6	0.5	-0.6	1.7
Ambulatory time before self-admin	6.1	6.3	7.1	2.6	2.4	-2.7	2.4
Ambulatory time after self-admin	0.7	0.8	1.4	0.8	0.7	-1.2	0.6
Bone: tissue strength	0.1	0.1	0.2	0.5	0.4	-0.2	-0.0
Total heroin consumption	0.3	0.3	1.0	-0.4	-0.3	0.2	1.0
Bone: trabecular number	1.2	2.0	3.4	1.3	1.3	-1.1	1.8
Bone: trabecular spacing	0.2	0.2	0.8	-0.1	-0.1	0.1	-0.9
Bone: trabecular thickness	0.2	0.2	0.4	-0.5	-0.4	0.1	0.6
Bone: trabecular tissue density	2.6	3.7	4.8	2.1	2.2	-2.2	1.0
Water consumed over 24 hours	0.9	1.1	1.8	1.2	1.1	-1.3	-0.3
Number of responses in last shaping day	1.5	1.5	2.7	1.2	0.9	-1.1	1.6