Hub : Genes

Cnih2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Cnih2 0.04 0.03 4.0e-03 0.02 0.01 0 0.01 2.3e-03 1.3e-02 3.1e-01 1.9e-02
2 PL isoform ratio XM_017589440.2 0.03 0.02 3.6e-03 0 0.01 0.01 0 2.0e-01 2.2e-02 3.4e-02 1.6e-01
3 OFC mRNA stability Cnih2 0.22 0.12 1.3e-03 0.04 0.17 0.13 0.15 3.8e-02 7.1e-05 5.5e-04 2.4e-04
4 Brain intron excision ratio chr1_202400839_202401240 0.05 0.04 1.8e-03 0.05 0.03 0.04 0.04 2.0e-05 1.5e-03 5.1e-05 5.9e-05
5 pVTA intron excision ratio chr1_202400839_202401240 0.08 0.06 7.9e-03 0.06 0.01 0.02 0.04 1.7e-03 1.3e-01 4.1e-02 9.3e-03
6 Brain gene expression Cnih2 0.31 0.08 0.0e+00 0.21 0.34 0.34 0.35 3.7e-19 3.3e-32 1.5e-32 2.9e-33
7 LHb gene expression Cnih2 0.36 0.19 6.7e-04 0.18 0.1 0.06 0.07 5.1e-05 2.0e-03 1.6e-02 1.2e-02
8 BLA gene expression Cnih2 0.43 0.15 2.1e-11 0.18 0.2 0.18 0.18 4.8e-10 1.0e-10 8.6e-10 6.4e-10
9 IL gene expression Cnih2 0.65 0.16 2.5e-07 0.17 0.25 0.22 0.28 7.6e-05 9.5e-07 4.8e-06 2.5e-07
10 BLA intron excision ratio chr1_202400839_202401240 0.08 0.06 6.6e-03 0.04 0.05 0.04 0.05 4.0e-03 1.5e-03 4.2e-03 9.2e-04
11 pVTA gene expression Cnih2 0.18 0.1 3.6e-05 0.08 0.09 0.08 0.09 2.1e-04 1.6e-04 3.5e-04 9.2e-05
12 OFC gene expression Cnih2 0.65 0.14 1.4e-07 0.2 0.21 0.22 0.28 1.6e-05 8.2e-06 5.3e-06 2.0e-07
13 PL gene expression Cnih2 0.66 0.12 0.0e+00 0.33 0.35 0.34 0.34 2.5e-37 6.1e-40 3.4e-39 3.6e-39
14 pVTA alternative TSS NM_001025132.1 0.12 0.09 8.0e-03 0.05 0.02 0.04 0.03 3.1e-03 3.6e-02 1.1e-02 2.0e-02
15 NAcc gene expression Cnih2 0.16 0.08 1.9e-14 0.13 0.13 0.12 0.13 8.7e-15 1.7e-14 4.9e-14 1.7e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density2.74.57.4-0.8-1.92.10.3-0.32.3-1.32.12.4-2.62.72.52.72.7-2.6
Area under the delay curve0.50.61.90.4-0.30.4-0.10.10.5-1.40.70.7-0.60.71.10.90.9-1.1
BMI with tail4.915.825.0-2.6-4.64.52.6-2.64.5-0.55.04.6-3.64.15.03.94.3-4.6
BMI without tail2.14.38.1-1.4-2.42.31.5-1.52.1-0.52.92.3-1.72.02.82.02.3-2.4
Body weight2.611.118.5-4.2-4.34.13.9-3.93.81.84.03.4-2.22.32.92.62.3-2.7
Weight adjusted by age1.41.54.8-1.6-1.41.32.2-2.21.11.70.91.2-0.30.50.50.30.1-0.2
Bone surface4.88.513.9-2.8-3.43.51.6-1.63.70.42.83.4-3.43.42.53.42.9-2.9
Bone volume2.94.98.7-1.6-2.42.60.6-0.62.7-0.42.02.5-2.92.82.12.62.4-2.4
Breakpoint value in progressive ratio session1.82.04.4-2.1-1.81.81.6-1.61.71.81.21.4-1.11.00.70.70.7-0.7
Number of licking bursts0.20.30.5-0.7-0.60.60.4-0.40.60.60.40.4-0.60.70.30.40.3-0.3
Context. condit. distance diff. score0.91.13.01.71.3-1.3-1.41.4-1.2-1.3-0.8-1.00.7-0.5-0.3-0.9-0.40.6
Locomotion velocity, session 10.20.31.0-0.00.4-0.40.5-0.5-0.60.3-0.3-0.41.0-0.6-0.4-0.6-0.40.6
Locomotion distance, session 11.72.13.5-0.8-1.51.50.9-0.91.6-0.81.71.6-1.21.81.91.51.7-1.8
Locomotion velocity, session 22.12.44.1-1.9-2.01.91.9-1.91.70.81.91.7-0.90.91.51.01.1-1.3
Locomotion distance, session 21.52.13.3-1.1-1.61.51.3-1.31.6-0.51.81.7-1.01.21.71.31.4-1.8
Locomotion velocity, session 30.20.30.70.3-0.30.3-0.10.10.4-0.70.60.6-0.50.50.90.20.8-0.7
Locomotion distance, session 30.00.00.00.10.1-0.1-0.10.1-0.1-0.1-0.00.0-0.1-0.0-0.0-0.10.1-0.1
Stereotopy head waving bouts, day 30.30.42.20.90.3-0.3-0.60.6-0.0-1.50.40.2-0.10.50.70.40.7-0.5
Stereotopy head waving duration, day 30.40.42.11.10.6-0.5-1.01.0-0.2-1.4-0.1-0.1-0.10.40.30.20.4-0.3
Locomotion velocity, session 70.60.61.70.5-0.40.4-0.50.50.6-1.30.90.7-0.60.61.30.40.9-1.3
Locomotion distance, session 70.30.31.10.0-0.40.30.4-0.40.4-0.61.00.60.10.21.00.40.6-0.9
Stereotopy head waving bouts, day 70.40.51.50.4-0.10.2-1.11.10.4-0.90.00.3-1.21.10.30.60.7-0.4
Stereotopy head waving duration, day 71.82.24.8-1.1-1.61.70.2-0.21.8-0.21.41.7-2.22.01.41.81.7-1.5
Locomotion velocity, session 80.50.51.9-1.1-0.70.61.4-1.40.50.90.60.60.2-0.00.20.40.2-0.1
Locomotion distance, session 80.10.21.00.60.1-0.1-0.30.30.0-1.00.30.0-0.00.40.5-0.20.3-0.4
Degree of sensitization distance0.50.51.3-0.0-0.60.50.4-0.40.7-0.81.00.8-0.20.51.10.70.8-0.9
Degree of sensitization stereotypy0.70.82.5-0.7-1.01.1-0.20.21.00.20.60.9-1.61.30.60.90.9-0.6
Conditioned locomotion0.60.72.4-1.5-1.00.81.6-1.60.60.80.80.20.3-0.20.0-0.1-0.5-0.1
Cocaine response after cond. corrected0.60.71.51.21.1-1.1-0.70.7-1.1-1.1-0.6-0.80.8-0.5-0.3-0.7-0.50.5
Cocaine response after cond. not corrected0.30.41.11.00.9-0.9-0.70.7-0.8-0.8-0.5-0.50.4-0.1-0.1-0.3-0.10.3
Cocaine response before conditioning0.50.61.2-1.0-0.91.00.5-0.50.81.00.40.9-1.10.70.40.80.7-0.4
Saline control response2.73.65.8-2.3-2.32.32.4-2.42.01.02.12.0-1.11.11.62.01.5-1.3
Bone: connectivity density4.67.210.9-1.9-2.93.01.3-1.33.2-0.72.83.1-2.93.32.83.32.9-3.0
Bone: cortical apparent density0.10.10.4-0.6-0.30.30.7-0.70.10.40.30.10.20.10.0-0.0-0.20.2
Bone: cortical area0.30.41.8-1.2-0.70.60.8-0.80.41.30.20.10.0-0.3-0.3-0.4-0.40.3
Bone: cortical porosity0.70.81.6-0.3-0.80.80.2-0.21.0-0.61.01.0-0.90.91.21.11.1-1.3
Bone: cortical porosity1.01.11.8-0.7-1.11.10.7-0.71.3-0.21.31.2-0.80.91.21.31.2-1.3
Bone: cortical thickness1.42.38.3-2.6-1.31.02.5-2.50.42.90.70.20.9-0.9-0.4-0.6-0.90.7
Bone: cortical thickness0.80.92.3-1.1-0.20.11.5-1.5-0.51.50.2-0.31.3-1.0-0.4-0.6-0.80.8
Bone: cortical tissue density0.10.20.6-0.6-0.40.30.8-0.80.10.50.40.10.20.00.0-0.0-0.20.3
Condit. Reinf. active minus inactive responses0.30.40.6-0.7-0.70.70.4-0.40.8-0.10.60.7-0.80.70.60.40.6-0.5
Condit. Reinf. active-inactive response ratio0.10.10.4-0.4-0.30.30.0-0.00.4-0.10.10.3-0.60.60.10.10.3-0.2
Condit. Reinf. active responses0.20.20.4-0.6-0.60.60.2-0.20.6-0.20.50.5-0.50.40.5-0.00.3-0.4
Condit. Reinf. inactive responses0.00.10.2-0.0-0.30.2-0.10.10.3-0.30.40.2-0.20.00.4-0.20.0-0.2
Incentive salience index mean0.60.71.1-0.9-1.01.00.6-0.61.0-0.21.00.9-0.90.81.00.40.7-0.8
Condit. Reinf. lever presses0.20.20.8-0.9-0.70.70.5-0.50.60.50.50.3-0.50.20.3-0.3-0.1-0.1
Condit. Reinf. active minus inactive responses0.30.41.30.3-0.00.2-1.01.00.4-0.6-0.20.3-1.11.00.30.50.7-0.5
Condit. Reinf. active-inactive response ratio0.50.62.40.80.5-0.4-1.51.5-0.1-0.9-0.8-0.4-0.60.4-0.3-0.4-0.00.1
Condit. Reinf. active responses1.11.53.5-0.2-0.91.0-0.30.31.2-0.70.81.2-1.81.91.21.61.6-1.4
Condit. Reinf. inactive responses2.02.45.3-0.7-1.41.50.7-0.71.4-0.41.71.8-1.61.91.92.32.1-1.9
Condit. Reinf. lever presses1.82.54.4-2.1-2.02.11.1-1.11.91.11.31.7-2.01.51.11.61.3-1.0
Condit. Reinf. lever reinforcers received1.11.63.7-0.6-1.11.3-0.10.11.4-0.30.91.4-1.91.91.21.71.6-1.4
Conditioned reinforcement - actives0.40.40.80.50.7-0.6-0.80.8-0.60.2-0.9-0.60.1-0.4-0.8-0.6-0.40.7
Conditioned reinforcement - inactives3.94.48.62.52.6-2.4-2.92.9-2.1-1.5-2.6-2.10.7-1.1-2.0-1.6-1.21.5
Conditioned locomotion6.88.212.63.33.5-3.5-3.23.2-3.2-1.3-3.3-3.12.2-2.3-2.6-2.6-2.12.3
Patch foraging indifference point 0 sec0.10.10.50.4-0.00.1-0.50.50.3-0.5-0.10.1-0.50.70.10.20.3-0.0
Patch foraging indifference point AUC1.71.94.7-2.2-1.81.71.8-1.81.51.81.31.3-0.70.90.51.10.6-0.5
Delay disc. indifference point, 0s delay0.50.63.41.00.2-0.2-0.00.0-0.2-1.80.70.30.20.31.10.81.1-1.0
Delay disc. indifference point, 16s delay0.50.51.90.90.4-0.2-1.21.20.1-1.4-0.30.0-1.00.60.20.20.2-0.4
Delay disc. indifference point, 2s delay0.10.10.30.40.2-0.1-0.50.5-0.1-0.4-0.0-0.20.00.10.10.30.1-0.3
Delay disc. indifference point, 24s delay0.10.10.30.20.4-0.40.2-0.2-0.4-0.3-0.1-0.20.5-0.5-0.0-0.2-0.30.2
Delay disc. indifference point, 4s delay0.30.41.40.5-0.00.0-0.10.10.1-1.20.70.4-0.10.30.90.80.8-0.9
Delay disc. indifference point, 8s delay0.40.41.60.2-0.20.20.3-0.30.1-1.30.70.5-0.00.30.90.80.8-0.9
Indifference point function ln k4.96.813.23.63.3-3.3-2.72.7-3.1-2.2-2.4-2.72.3-2.3-1.5-2.5-1.71.7
Indifference point function log k4.96.813.23.63.3-3.3-2.72.7-3.1-2.2-2.4-2.72.3-2.3-1.5-2.5-1.71.7
Patch foraging total patch changes 0 sec0.00.00.10.30.2-0.2-0.10.1-0.1-0.1-0.2-0.20.10.1-0.2-0.1-0.10.4
Patch foraging total patch changes 12 sec3.44.47.3-2.5-2.72.62.3-2.32.51.42.32.3-1.62.01.61.91.5-1.4
Patch foraging total patch changes 18 sec0.81.02.4-0.9-1.21.20.4-0.41.20.11.11.1-1.11.50.81.11.0-0.9
Patch foraging total patch changes 24 sec1.11.32.9-1.7-1.41.31.7-1.71.31.51.01.0-0.31.00.50.90.5-0.3
Patch foraging total patch changes 6 sec1.42.12.9-1.4-1.71.71.3-1.31.60.31.61.6-1.31.71.31.61.4-1.2
Patch foraging time to switch 0 sec3.24.97.6-1.9-2.62.61.2-1.22.8-0.32.52.5-2.72.22.42.22.1-2.4
Patch foraging water rate 0 sec5.58.812.42.83.5-3.5-2.42.4-3.5-0.3-3.5-3.53.0-2.4-3.1-3.1-2.93.1
Patch foraging water rate 12 sec8.112.320.33.94.5-4.5-2.72.7-4.4-1.2-3.8-4.03.9-3.3-3.2-3.1-3.02.9
Patch foraging water rate 18 sec2.43.25.72.32.4-2.4-1.41.4-2.3-1.0-1.9-2.02.0-1.5-1.3-1.7-1.41.2
Patch foraging water rate 24 sec4.96.910.62.73.2-3.3-1.91.9-3.2-0.7-2.9-3.02.9-2.5-2.4-2.7-2.42.3
Patch foraging water rate 6 sec4.05.89.52.33.0-3.1-1.41.4-3.1-0.7-2.5-2.92.8-2.2-2.3-2.4-2.42.2
Seeking ratio, delayed vs. immediate footshock0.40.51.0-0.1-0.50.50.4-0.40.6-0.80.70.8-0.90.81.00.80.8-0.9
Distance traveled before self-admin0.20.20.4-0.5-0.60.60.3-0.30.60.60.30.3-0.50.40.10.20.2-0.2
Distance traveled after self-admin0.10.10.2-0.2-0.30.40.1-0.10.50.4-0.00.2-0.30.2-0.10.00.0-0.1
Extensor digitorum longus weight4.116.035.7-6.0-5.34.95.5-5.54.03.94.53.7-1.91.92.72.31.8-2.1
Bone: elastic displacement2.02.34.80.81.6-1.7-0.30.3-2.00.2-1.4-1.92.2-1.9-1.6-1.5-1.81.4
Bone: elastic work0.60.72.3-1.1-0.40.21.5-1.5-0.31.20.4-0.31.3-0.9-0.3-0.4-0.80.4
Bone: endosteal estimation0.51.25.01.60.4-0.2-1.61.60.3-2.20.10.3-1.00.80.90.51.0-1.0
Bone: endosteal perimeter0.91.95.71.70.4-0.1-2.22.20.6-2.4-0.20.4-1.71.50.80.81.2-1.2
Epididymis fat weight1.33.08.42.82.0-1.9-2.92.9-1.6-2.1-1.5-1.50.4-0.3-0.6-0.8-0.50.5
Delta time in closed arm before/after self-admin0.20.21.0-0.2-0.10.01.0-1.0-0.10.00.60.30.8-0.40.40.00.2-0.3
Delta time in open arm before/after self-admin0.20.20.5-0.10.1-0.0-0.70.7-0.00.7-0.5-0.2-0.20.1-0.6-0.2-0.60.5
Diff in mean of infusions in LGA sessions0.20.21.1-0.8-0.40.30.3-0.30.21.0-0.00.1-0.30.1-0.4-0.1-0.30.3
Delay discount exponential model param0.40.41.4-0.30.3-0.3-0.00.0-0.41.2-0.6-0.60.4-0.6-1.0-0.8-0.81.0
Extinction: sum of active levers before priming3.63.66.4-2.1-2.52.51.8-1.82.31.22.12.0-1.81.81.61.31.4-1.5
Active lever presses in extinction session 60.90.84.8-1.5-0.80.71.2-1.20.62.20.00.10.1-0.3-0.7-0.4-0.70.4
Bone: final force1.52.44.9-2.2-2.02.01.8-1.81.91.21.61.5-1.00.91.11.00.9-1.0
Bone: final moment1.32.14.3-2.1-1.91.91.7-1.71.71.11.51.4-1.00.81.01.00.9-1.0
Food consumed during 24 hour testing period0.30.41.0-0.30.4-0.3-0.20.2-0.30.8-0.8-0.6-0.1-0.8-1.0-0.4-0.80.8
Glucose0.91.46.61.80.7-0.5-1.81.8-0.2-2.6-0.10.1-0.80.80.70.60.9-0.7
Heart weight1.31.95.52.11.6-1.5-2.12.1-1.3-2.3-1.0-1.00.40.0-0.3-0.3-0.20.2
Delay discount hyperbolic model param0.30.41.1-0.30.3-0.3-0.00.0-0.41.0-0.6-0.50.4-0.5-0.9-0.8-0.81.0
Intermittent access intake day 1-15 change1.21.22.40.51.2-1.2-0.90.9-1.30.3-1.5-1.20.3-0.9-1.5-1.4-1.31.3
Intermittent access intake escalation0.70.71.40.50.9-0.9-0.80.8-0.9-0.1-1.2-0.80.3-0.5-1.0-1.0-0.90.9
Intermittent access intake escalation 21.01.02.00.31.0-1.0-0.60.6-1.00.5-1.3-1.10.7-1.0-1.4-1.4-1.11.3
Intermitt. access day 1 inactive lever presses1.51.64.81.31.3-1.2-2.22.2-1.0-1.3-1.3-1.3-0.1-0.6-1.0-0.8-0.70.7
Intermitt. access day 15 inactive lever presses1.31.43.61.21.3-1.2-1.91.9-1.0-1.0-1.5-1.0-0.3-0.4-1.1-0.9-0.70.7
Intermitt. access escalation Index1.51.35.32.21.2-1.1-1.61.6-0.9-2.3-0.3-0.60.6-0.10.4-0.00.2-0.4
Intermittent access day 1 total infusions2.32.711.62.31.0-0.7-2.62.6-0.3-3.4-0.20.2-1.11.30.90.91.6-1.1
Intermittent access day 15 total infusions3.23.610.52.72.2-2.0-3.23.2-1.7-2.6-1.9-1.3-0.1-0.1-0.9-0.8-0.10.6
Intermittent access terminal intake (last 3 days)2.32.58.72.21.6-1.4-2.92.9-1.2-2.3-1.4-0.8-0.60.3-0.5-0.40.30.2
Intermittent access total infusions1.82.07.31.91.0-0.8-2.52.5-0.5-2.7-0.5-0.0-1.11.10.40.41.2-0.7
Intermittent access day 1 locomotion1.81.98.61.50.4-0.2-1.91.90.1-2.90.40.7-0.91.31.21.11.7-1.3
Intermittent access day 15 total locomotion1.81.95.72.11.6-1.4-2.42.4-1.2-2.1-1.3-0.8-0.40.2-0.5-0.50.20.3
Intermittent access total locomotion2.32.610.62.31.2-1.0-2.82.8-0.6-3.3-0.6-0.1-1.11.10.50.41.1-0.7
Intermittent access standard deviation0.91.01.60.91.2-1.2-1.11.1-1.2-0.5-1.3-0.90.6-0.7-1.0-1.0-0.70.9
Left kidney weight0.82.43.91.31.6-1.6-1.71.7-1.6-0.7-1.5-1.91.2-1.1-1.5-2.0-1.71.4
Right kidney weight0.82.24.30.41.2-1.3-1.41.4-1.30.8-1.8-1.90.8-1.0-2.0-2.1-2.01.7
Cocaine induced anxiety0.10.10.4-0.20.2-0.2-0.00.0-0.20.5-0.4-0.40.2-0.5-0.6-0.4-0.40.6
Post-drug Anxiety0.60.73.0-1.5-0.60.50.9-0.90.41.7-0.1-0.10.0-0.5-0.8-0.2-0.80.7
Baseline Anxiety0.80.93.1-1.7-1.11.11.4-1.40.91.60.60.6-0.10.10.10.2-0.1-0.1
Tail length0.61.84.8-1.40.1-0.31.7-1.7-0.62.2-0.4-0.91.7-1.6-1.3-1.3-1.61.5
Length with tail0.83.010.6-3.3-1.71.52.9-2.91.12.91.00.60.2-0.6-0.30.1-0.60.4
Length without tail1.32.87.0-2.6-2.12.02.4-2.41.82.01.41.5-0.80.50.61.20.7-0.8
Times rat made contact with spout0.80.91.3-0.8-1.01.00.9-0.91.0-0.21.11.0-0.91.11.01.10.9-1.1
Lifetime Intake1.61.87.41.70.8-0.6-2.22.2-0.4-2.7-0.20.2-1.11.20.70.61.4-0.9
Liver weight, left0.20.20.70.60.5-0.5-0.10.1-0.80.0-0.2-0.60.7-0.7-0.4-0.5-0.40.4
Liver weight, right0.10.10.60.40.3-0.40.3-0.3-0.70.00.0-0.30.8-0.60.0-0.1-0.0-0.0
Locomotor activity1.72.74.91.62.1-2.2-0.90.9-2.2-0.2-1.8-1.92.2-1.6-1.5-1.7-1.41.3
Locomotor testing distance2.03.36.41.92.5-2.5-0.90.9-2.5-0.5-1.9-2.02.5-1.8-1.5-1.6-1.41.3
Locomotor testing rearing0.91.33.51.91.7-1.6-1.21.2-1.6-1.4-1.0-0.91.2-0.4-0.50.0-0.10.1
Locomotion in novel chamber3.13.86.72.62.4-2.3-2.52.5-2.1-1.4-2.3-1.91.0-1.0-1.6-1.8-0.91.4
Locomotion in novel chamber post-restriction1.92.35.22.01.8-1.8-2.32.3-1.7-1.2-1.6-1.40.9-0.8-1.0-1.1-0.71.0
Fecal boli incidents, locomotor time 10.20.20.6-0.3-0.00.1-0.50.50.20.8-0.4-0.1-0.70.3-0.6-0.2-0.40.4
Change in fecal boli incidents, locomotor task0.60.51.80.2-0.40.41.0-1.00.4-0.70.90.7-0.00.31.10.61.4-0.9
Time >=10cm from walls, locomotor time 10.91.02.90.6-0.10.3-0.90.90.8-1.70.20.8-1.51.40.90.61.3-1.0
Bouts of movement, locomotor time 10.60.72.5-1.6-1.01.01.0-1.00.90.90.50.6-1.10.60.10.50.0-0.2
Total resting periods, locomotor time 10.60.61.8-1.3-0.91.00.6-0.60.90.70.40.7-1.30.80.20.60.2-0.3
Rest time, locomotor task time 11.71.92.91.21.6-1.5-1.51.5-1.5-0.2-1.7-1.60.9-1.3-1.4-1.3-1.51.2
Distance moved, locomotor task time 10.91.02.4-0.2-1.01.00.6-0.61.0-0.71.21.2-0.61.11.31.11.5-1.2
Vertical activity count, locomotor time 10.50.51.11.11.0-1.0-0.80.8-1.0-0.6-0.7-0.70.4-0.3-0.4-0.6-0.10.5
Time >=10cm from walls, locomotor time 20.10.10.2-0.0-0.10.1-0.20.20.3-0.2-0.10.1-0.30.40.1-0.30.4-0.1
Bouts of movement, locomotor time 20.40.51.0-1.0-0.80.90.8-0.80.70.40.70.6-0.70.50.40.80.5-0.5
Total resting periods, locomotor time 20.30.40.7-0.7-0.70.70.4-0.40.70.10.60.6-0.70.60.40.80.5-0.6
Rest time, locomotor task time 21.41.63.21.81.6-1.5-1.61.6-1.4-1.4-1.2-1.20.6-0.9-0.8-0.8-1.00.6
Distance moved, locomotor task time 20.60.72.0-1.1-1.00.91.4-1.40.71.10.70.6-0.10.20.30.20.6-0.2
Vertical activity count, locomotor time 20.91.01.7-0.10.7-0.80.7-0.7-1.21.2-0.8-0.91.3-1.3-1.0-1.2-0.81.2
Light reinforcement 10.10.20.50.70.7-0.7-0.40.4-0.6-0.3-0.6-0.50.5-0.3-0.5-0.2-0.30.3
Light reinforcement 21.21.63.01.01.3-1.2-1.71.7-1.10.1-1.7-1.40.1-0.7-1.5-1.3-1.41.3
Bone: marrow area0.61.25.41.60.4-0.3-1.61.60.3-2.30.10.3-1.00.80.90.51.1-1.0
Bone: maximum diameter0.10.10.6-0.4-0.10.2-0.20.20.30.7-0.4-0.2-0.4-0.1-0.6-0.4-0.30.4
Bone: maximum force3.05.38.8-2.5-2.92.91.7-1.73.00.52.52.5-2.42.32.12.02.0-2.2
Bone: maximum moment2.74.67.5-2.3-2.72.71.6-1.62.70.42.32.4-2.32.22.01.91.9-2.0
Mean time between licks in bursts0.30.52.0-0.7-0.50.41.4-1.40.50.70.60.60.5-0.00.60.40.4-0.3
Mean num. licks in bursts0.10.11.00.40.2-0.2-0.20.2-0.1-1.00.10.10.00.00.30.30.3-0.4
Cd content in liver1.71.93.31.41.6-1.6-1.51.5-1.4-0.3-1.8-1.50.8-1.2-1.6-1.2-1.20.9
Co content in liver2.12.56.21.41.9-2.0-0.30.3-1.9-0.3-1.4-1.52.5-2.3-1.3-1.4-1.31.6
Cu content in liver0.30.40.8-0.7-0.90.80.6-0.60.60.20.90.7-0.50.40.80.50.6-0.4
Fe content in liver0.10.10.3-0.3-0.10.10.2-0.20.10.6-0.1-0.10.2-0.1-0.3-0.1-0.30.3
K content in liver2.82.84.0-1.7-2.02.01.2-1.21.9-0.12.01.9-1.81.61.81.61.6-1.6
Mg content in liver3.13.25.5-0.5-1.61.70.2-0.21.8-1.41.92.0-2.22.12.22.12.4-2.2
Mn content in liver1.61.84.5-2.1-1.81.81.0-1.01.71.11.11.3-1.61.40.61.10.7-0.7
Na content in liver0.50.52.5-1.2-0.50.40.7-0.70.21.6-0.1-0.20.2-0.3-0.5-0.7-0.70.7
Rb content in liver0.81.04.41.60.4-0.3-1.11.1-0.1-2.10.20.5-0.60.61.00.91.2-1.1
Se content in liver0.60.72.0-0.2-0.50.7-0.80.81.0-0.60.20.6-1.41.30.31.10.7-1.0
Sr content in liver1.00.94.2-1.7-0.80.81.4-1.40.52.00.10.20.2-0.5-0.6-0.1-0.61.0
Zn content in liver0.91.01.9-1.4-1.31.31.1-1.11.30.61.21.1-0.90.50.80.70.6-0.9
Bone: minimum diameter0.91.75.21.2-0.20.4-1.51.50.7-2.30.70.8-1.61.41.41.01.5-1.6
Time in familiar zone, hab. session 10.20.10.40.4-0.00.1-0.50.50.1-0.40.10.3-0.60.40.40.20.5-0.5
Time in novel zone, hab. session 10.60.51.70.50.9-0.90.1-0.1-0.8-0.1-0.6-0.71.3-1.0-0.7-0.5-0.70.9
Total zone transitions, hab. session 10.70.91.5-1.2-1.21.21.1-1.11.20.51.11.0-0.60.91.00.60.7-0.7
Total locomotion distance, hab. session 10.10.10.60.70.3-0.3-0.50.5-0.2-0.8-0.0-0.30.00.00.3-0.5-0.1-0.0
Locomotion velocity, hab. session 10.00.10.20.2-0.10.1-0.10.10.2-0.50.30.0-0.20.20.4-0.20.1-0.2
Time in familiar zone, hab. session 20.20.20.9-0.00.3-0.40.7-0.7-0.60.4-0.1-0.21.0-0.8-0.2-0.2-0.30.1
Time in novel zone, hab. session 20.50.51.2-0.1-0.70.7-0.30.30.9-0.60.60.7-1.11.10.70.80.8-0.6
Total zone transitions, hab. session 25.16.711.3-1.2-2.52.61.1-1.12.9-1.22.82.9-2.63.43.13.03.1-3.3
Total locomotion distance, hab. session 21.21.63.50.2-0.90.90.0-0.01.1-1.61.41.3-1.31.91.81.21.7-1.8
Locomotion velocity, hab. session 21.01.43.30.4-0.70.7-0.30.31.0-1.61.11.1-1.31.81.61.01.5-1.7
Novel to familiar place preference ratio0.80.82.4-1.0-1.21.30.1-0.11.20.40.60.9-1.51.20.60.90.6-0.3
Novelty place preference0.50.52.0-0.5-0.91.0-0.20.20.90.10.40.7-1.41.00.40.80.6-0.2
Time in novel zone, NPP test0.40.41.6-0.4-0.80.9-0.20.20.8-0.00.40.7-1.30.90.50.80.6-0.2
Total zone transitions, NPP test2.23.14.4-1.8-2.12.11.6-1.62.10.42.01.9-1.41.81.91.51.6-1.8
Total locomotion distance, NPP test0.20.31.0-0.1-0.60.50.3-0.30.6-0.60.80.5-0.40.71.00.20.6-0.8
Locomotion velocity, NPP test0.20.30.8-0.2-0.60.50.3-0.30.6-0.40.80.4-0.40.70.90.10.5-0.6
Intraocular pressure1.72.44.41.01.6-1.6-1.81.8-1.50.2-2.1-1.80.7-0.8-2.1-1.5-1.81.8
Delta distance traveled before/after self-admin0.00.00.10.20.2-0.2-0.10.1-0.1-0.0-0.2-0.10.3-0.2-0.2-0.2-0.10.1
Delta ambulatory time before/after self-admin0.00.00.20.20.1-0.10.2-0.2-0.10.0-0.10.10.4-0.3-0.1-0.1-0.10.0
Parametrial fat weight1.12.16.82.51.2-1.2-2.62.6-0.8-2.6-0.5-0.8-0.40.80.2-0.20.2-0.5
Pavlov. Cond. lever latency0.20.30.40.50.7-0.6-0.40.4-0.7-0.2-0.6-0.60.5-0.6-0.5-0.3-0.50.4
Pavlov. Cond. magazine entry latency0.81.13.0-0.3-0.91.0-0.20.21.1-0.80.91.0-1.61.71.00.91.2-1.2
Pavlov. Cond. change in total contacts0.30.31.3-0.3-0.40.5-0.60.60.60.30.10.3-1.21.00.2-0.10.3-0.2
Pavlov. Cond. index score0.10.10.3-0.4-0.30.3-0.00.00.30.30.10.2-0.60.6-0.1-0.10.10.0
Pavlov. Cond. latency score0.10.10.4-0.2-0.30.3-0.10.10.40.00.20.3-0.50.60.20.00.3-0.2
Pavlov. Cond. lever contacts0.00.00.1-0.2-0.20.10.1-0.10.20.10.20.1-0.20.30.1-0.10.1-0.1
Pavlov. Cond. magazine entry number0.10.10.40.50.3-0.30.1-0.1-0.2-0.70.2-0.00.5-0.50.40.20.1-0.3
Pavlov. Cond. intertrial magazine entries0.50.61.20.50.8-0.8-0.70.7-0.80.1-1.0-0.90.5-0.7-0.9-0.8-0.81.1
Pavlov. Cond. lever-magazine prob. diff.0.20.20.5-0.6-0.60.60.2-0.20.50.40.30.4-0.70.70.20.10.3-0.2
Pavlov. Cond. response bias0.10.10.2-0.4-0.20.2-0.10.10.10.5-0.1-0.0-0.40.4-0.3-0.2-0.10.2
Pavlov. Cond. lever latency0.30.41.01.00.9-0.9-0.30.3-0.7-0.7-0.5-0.51.0-0.4-0.3-0.5-0.30.2
Pavlov. Cond. magazine entry latency3.64.26.5-2.4-2.52.61.9-1.92.41.12.12.3-2.11.81.81.91.7-1.7
Pavlov. Cond. change in total contacts1.72.35.9-1.8-2.02.10.6-0.62.00.81.21.6-2.41.61.01.41.2-1.2
Pavlov. Cond. index score1.92.44.5-2.1-2.12.11.2-1.21.91.11.41.7-2.01.21.11.31.1-1.1
Pavlov. Cond. latency score1.51.93.6-1.9-1.91.91.1-1.11.71.01.31.4-1.81.01.01.00.9-1.0
Pavlov. Cond. lever contacts0.20.31.3-1.0-0.60.60.4-0.40.41.10.00.2-0.6-0.1-0.20.3-0.10.2
Pavlov. Cond. magazine entry number5.36.510.53.23.2-3.2-2.42.4-3.1-1.6-2.5-2.82.7-2.1-2.0-2.3-2.02.0
Pavlov. Cond. intertrial magazine entries0.91.21.91.41.4-1.3-1.41.4-1.2-0.7-1.2-1.20.8-0.7-0.9-0.9-0.70.9
Pavlov. Cond. lever-magazine prob. diff.2.32.95.3-2.3-2.32.31.4-1.42.11.21.61.8-2.11.31.31.41.2-1.2
Pavlov. Cond. response bias1.21.63.3-1.8-1.61.71.1-1.11.51.31.01.3-1.50.90.71.20.9-0.7
Time in closed arm before self-admin0.10.10.5-0.1-0.20.3-0.50.50.4-0.0-0.00.1-0.70.60.10.30.1-0.2
Time in closed arm after self-admin0.00.00.1-0.1-0.10.10.2-0.20.2-0.30.30.1-0.00.10.3-0.00.1-0.3
Time in open arm before self-admin0.30.31.00.70.5-0.60.4-0.4-0.8-0.90.2-0.21.0-0.60.3-0.20.1-0.1
Time in open arm after self-admin0.40.50.80.50.7-0.8-0.60.6-0.90.2-0.7-0.70.9-0.8-0.7-0.5-0.80.8
Bone: periosteal estimation0.00.10.30.2-0.20.2-0.50.50.4-0.40.10.1-0.50.20.2-0.10.2-0.3
Bone: periosteal perimeter0.30.41.3-0.3-0.60.7-0.20.21.0-0.40.40.7-1.10.90.50.70.7-0.6
Bone: post-yield work6.08.218.4-0.5-2.52.7-0.70.73.4-2.22.53.0-4.34.13.22.73.3-3.4
Progressive ratio test 1 active lever presses1.11.13.41.51.3-1.2-1.81.8-1.1-1.3-1.0-0.60.2-0.0-0.4-0.30.10.3
Progressive ratio test 1 breakpoint1.01.13.11.31.3-1.2-1.71.7-1.2-1.1-1.1-0.70.3-0.2-0.5-0.4-0.00.5
Progressive ratio test 1 inactive lever presses0.40.41.51.00.7-0.6-1.01.0-0.4-1.2-0.4-0.2-0.10.00.00.00.3-0.1
Progressive ratio test 2 active lever presses1.71.85.61.81.6-1.4-2.42.4-1.2-1.7-1.4-0.8-0.30.1-0.7-0.50.20.4
Progressive ratio test 2 breakpoint2.52.86.82.22.1-2.0-2.62.6-1.8-1.6-1.9-1.40.3-0.5-1.2-1.1-0.41.0
Progressive ratio test 2 inactive lever presses3.43.910.83.02.4-2.1-3.33.3-1.7-2.9-1.9-1.4-0.1-0.1-0.9-0.6-0.00.5
Incentive Sensitization - Responses0.30.30.80.40.2-0.1-0.90.9-0.1-0.6-0.30.1-0.80.60.0-0.00.7-0.3
Incentive Sensitization - Breakpoint0.30.31.20.60.4-0.3-1.11.1-0.3-0.7-0.5-0.1-0.70.4-0.2-0.30.5-0.1
Sum of active levers in priming session hrs 5-61.41.46.6-1.2-0.10.10.6-0.6-0.12.6-1.0-0.60.3-0.7-1.7-1.4-1.61.5
Progressive ratio4.34.97.0-1.3-2.52.51.2-1.22.6-0.62.62.6-2.42.62.62.62.3-2.5
Food seeking constrained by brief footshock0.20.31.3-0.5-0.40.31.2-1.20.10.40.50.30.2-0.10.20.3-0.0-0.2
Seeking ratio, punishment vs. effort2.73.35.71.32.1-2.2-0.50.5-2.30.2-1.9-2.12.3-2.4-1.9-2.0-1.91.9
Retroperitoneal fat weight2.58.421.14.63.4-3.3-4.44.4-2.8-3.6-2.6-2.60.9-0.7-1.3-1.6-1.01.0
Reaction time number correct0.20.31.2-0.5-0.0-0.00.5-0.5-0.31.1-0.3-0.40.5-0.3-0.7-0.6-0.80.4
Reaction time mean minus median1.72.25.2-2.3-2.02.01.3-1.31.71.51.31.4-1.71.20.81.10.8-0.8
Reaction time mean minus median AUC0.60.83.1-1.8-1.21.11.2-1.20.61.50.60.5-0.60.4-0.00.3-0.10.1
Reaction time num false alarms0.60.93.30.50.8-0.90.4-0.4-1.10.2-0.4-1.01.8-1.3-0.5-1.1-1.01.0
Reaction time num false alarms AUC0.40.52.0-0.30.1-0.31.0-1.0-0.50.70.2-0.41.4-1.0-0.1-0.7-0.70.7
Reaction time trials correct on left0.20.31.2-0.5-0.0-0.00.5-0.5-0.31.1-0.3-0.40.5-0.3-0.7-0.6-0.80.4
Reaction time trials on left0.30.41.5-0.6-0.1-0.00.6-0.6-0.31.2-0.3-0.40.6-0.3-0.8-0.7-0.90.5
Reaction time mean0.00.00.3-0.2-0.10.1-0.10.1-0.10.5-0.20.1-0.40.0-0.10.00.00.3
Reaction time mean AUC0.00.10.3-0.1-0.10.2-0.20.2-0.10.3-0.10.1-0.60.2-0.10.00.10.3
Median of all reaction times0.00.10.20.30.2-0.2-0.40.4-0.30.1-0.3-0.1-0.2-0.1-0.1-0.10.10.3
Reaction time omissions0.70.92.6-1.6-1.31.21.3-1.30.81.60.90.7-0.40.40.40.30.1-0.2
Reaction time false alarm rate0.20.31.40.20.4-0.60.4-0.4-0.70.0-0.0-0.51.2-1.0-0.0-0.6-0.50.6
Reaction time premature initiation rate1.11.55.0-1.8-1.21.12.2-2.20.91.61.21.00.30.20.60.70.5-0.0
Reaction time premature initiations1.52.17.3-2.3-1.41.32.7-2.70.92.41.00.80.5-0.00.20.4-0.00.2
Std. dev. reaction times0.40.51.5-1.2-1.01.00.6-0.60.71.10.50.6-1.00.50.20.60.3-0.0
Reaction time trials completed0.30.41.5-0.6-0.1-0.00.6-0.6-0.31.2-0.3-0.40.6-0.3-0.8-0.7-0.90.5
Reaction time trials AUC0.20.31.0-0.40.0-0.10.5-0.5-0.31.0-0.3-0.40.6-0.3-0.7-0.6-0.70.4
Run reversals in cocaine runway, females2.22.24.2-0.6-1.41.41.5-1.51.3-0.82.01.5-1.01.22.11.32.0-1.6
Run reversals in cocaine runway, males2.62.54.50.31.4-1.5-0.00.0-1.71.2-1.5-1.72.1-2.1-1.9-1.9-1.81.9
Latency to leave start box in cocaine runway0.60.61.3-0.0-0.60.7-0.60.60.8-0.70.70.7-1.11.10.90.70.9-1.0
Latency to leave start box in cocaine runway, F0.40.41.3-0.0-0.60.6-0.30.30.6-0.50.70.7-0.80.90.90.51.2-0.7
Latency to leave start box in cocaine runway, M0.00.00.0-0.2-0.20.2-0.20.20.20.10.10.1-0.20.10.00.0-0.2-0.1
Std. dev. time between licks in bursts0.60.73.40.40.6-0.80.6-0.6-1.00.3-0.2-0.71.9-1.3-0.4-0.7-0.70.7
Total sessions with >9 infusions0.60.73.31.10.5-0.4-1.31.3-0.3-1.80.10.2-0.40.60.70.30.9-0.5
Short access day 1 total inactive lever presses1.71.95.72.11.6-1.5-2.42.4-1.2-1.9-1.1-1.10.5-0.3-0.5-0.4-0.10.2
Short access day 10 total inactive lever presses1.92.13.51.71.8-1.8-1.91.9-1.6-1.6-1.4-1.60.9-1.3-1.0-1.0-1.00.8
Short access day 1 total infusions1.61.76.81.70.6-0.5-2.12.1-0.2-2.60.10.1-0.81.00.90.61.2-1.0
Short access day 10 total infusions2.83.17.50.9-0.60.8-1.11.11.1-2.71.31.7-2.02.42.11.92.6-2.2
Short access total infusions1.21.34.60.9-0.00.1-1.21.20.3-2.10.70.8-1.01.41.31.11.7-1.3
Short access day 1 locomotion1.21.35.41.30.3-0.2-1.41.40.1-2.30.30.6-1.21.11.00.81.4-1.1
Short access day 10 total locomotion1.01.15.01.10.10.1-0.90.90.3-2.20.50.8-0.91.21.20.91.4-1.3
Short access total locomotion1.01.14.10.9-0.00.1-1.01.00.4-2.00.60.8-0.91.21.20.91.5-1.2
One hour access (0.3 mA shock)4.45.111.53.02.9-2.7-3.43.4-2.5-2.8-2.4-1.90.5-0.8-1.4-1.3-0.31.1
Compulsive drug intake1.41.45.1-1.5-1.11.02.3-2.30.71.51.10.70.8-0.30.50.60.2-0.3
One hour access (shock baseline)4.45.114.02.82.7-2.4-3.73.7-2.2-2.4-2.6-1.9-0.1-0.5-1.6-1.4-0.51.1
Social response proportion1.01.12.1-1.1-1.11.20.6-0.61.40.10.81.2-1.41.30.81.41.0-0.9
Social responses0.20.20.6-0.7-0.40.40.6-0.60.50.30.30.5-0.20.10.10.70.3-0.3
Social time0.20.20.9-0.7-0.30.31.0-1.00.30.60.20.30.0-0.00.00.50.2-0.0
Soleus weight3.08.714.83.83.6-3.6-3.23.2-3.3-2.3-2.9-3.32.3-2.7-2.0-2.9-2.31.9
Bone: stiffness2.94.57.9-2.0-2.62.71.2-1.22.80.32.22.4-2.52.42.02.02.1-2.0
Tibialis anterior weight4.314.743.3-6.6-4.74.36.0-6.03.15.83.32.6-0.80.51.01.20.3-0.5
Time to tail flick, vehicle, before self-admin0.80.81.1-0.7-1.01.00.9-0.91.1-0.11.01.0-0.80.91.00.81.0-0.8
Time to tail flick, vehicle, after self-admin1.92.13.7-1.2-1.61.51.6-1.61.3-0.21.91.7-0.91.21.81.41.4-1.4
Time to tail flick, test, before self-admin0.90.94.10.6-0.20.2-0.20.20.4-2.00.90.9-0.30.91.50.91.2-1.4
Time to tail flick, test, after self-admin0.10.10.2-0.30.1-0.10.4-0.40.00.1-0.2-0.00.1-0.1-0.2-0.1-0.40.3
Delta time to tail flick, vehicle, before/after SA0.70.71.3-0.8-0.90.90.8-0.80.8-0.21.11.1-0.70.81.10.90.8-0.9
Delta time to tail flick, test, before/after SA1.51.45.3-1.10.1-0.21.0-1.0-0.52.3-0.9-0.80.7-1.2-1.6-0.9-1.61.7
Tibia length0.30.94.6-1.7-0.80.80.8-0.80.72.1-0.2-0.1-0.2-0.5-1.0-0.6-1.00.6
Ambulatory time before self-admin0.20.21.0-0.5-0.60.6-0.00.00.60.60.10.2-1.00.5-0.10.20.1-0.1
Ambulatory time after self-admin0.20.30.90.4-0.20.3-0.80.80.6-0.5-0.10.2-1.00.70.10.30.2-0.4
Bone: tissue strength0.20.20.6-0.2-0.30.4-0.20.20.6-0.30.10.3-0.80.70.30.40.4-0.4
Total heroin consumption2.63.16.1-2.5-2.42.32.0-2.02.22.01.81.7-1.21.21.11.00.7-1.2
Bone: trabecular number2.53.97.3-1.0-1.92.10.2-0.22.2-0.91.82.2-2.72.72.02.62.3-2.3
Bone: trabecular spacing0.50.61.40.60.8-0.9-0.10.1-1.1-0.0-0.6-0.91.2-1.0-0.7-1.0-0.80.5
Bone: trabecular thickness0.80.92.00.5-0.30.4-0.80.80.6-1.40.50.8-1.41.21.21.21.3-1.0
Bone: trabecular tissue density3.44.76.72.42.6-2.6-2.42.4-2.1-1.1-2.5-2.41.5-2.0-2.0-2.4-2.01.7
Water consumed over 24 hours0.60.71.3-1.1-0.90.91.0-1.00.70.60.80.9-0.70.70.51.10.7-0.6
Number of responses in last shaping day0.80.81.41.01.2-1.2-1.21.2-1.1-0.4-0.9-0.90.8-0.9-0.7-0.4-0.80.7