Hub : Genes

Nudt18

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Nudt18 0.27 0.15 2.5e-07 0.09 0.08 0.08 0.08 1.2e-05 2.9e-05 4.5e-05 5.6e-05
2 Brain gene expression Nudt18 0.11 0.08 3.9e-07 0.04 0.07 0.07 0.07 1.7e-04 2.1e-07 2.1e-07 4.1e-07
3 NAcc gene expression Nudt18 0.18 0.11 5.6e-17 0.13 0.15 0.14 0.14 3.2e-15 1.4e-16 2.7e-16 3.7e-16
4 Adipose alternative TSS XM_039093515.1 0.02 0.02 2.8e-03 0.01 0.02 0.01 0.01 4.5e-02 2.4e-03 1.6e-02 1.9e-02
5 Adipose alternative TSS XM_039093516.1 0.02 0.02 2.8e-03 0.01 0.02 0.01 0.01 4.3e-02 2.2e-03 1.5e-02 1.7e-02
6 OFC gene expression Nudt18 0.26 0.17 6.7e-03 0.05 0.05 0.06 0.05 3.1e-02 2.4e-02 1.8e-02 2.7e-02
7 PL gene expression Nudt18 0.13 0.09 4.2e-13 0.12 0.11 0.11 0.11 1.4e-13 1.8e-12 3.0e-12 2.2e-12
8 Adipose gene expression Nudt18 0.02 0.02 7.8e-03 0.01 0.01 0.02 0.01 1.6e-02 9.2e-03 6.2e-03 1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.42.42.6-1.31.61.6-1.61.6-1.6-1.5-1.5
Area under the delay curve0.00.00.1-0.30.00.00.1-0.10.10.20.1
BMI with tail0.72.33.61.9-1.8-1.71.5-1.51.31.20.9
BMI without tail0.40.91.80.10.70.8-1.01.0-0.9-1.3-1.3
Body weight0.41.52.00.7-1.1-1.21.3-1.31.21.41.4
Weight adjusted by age1.31.52.10.7-1.0-1.11.3-1.31.31.41.4
Bone surface0.81.41.8-1.31.31.3-1.11.1-1.2-1.0-0.9
Bone volume0.91.62.0-1.31.41.4-1.21.2-1.3-1.1-1.1
Breakpoint value in progressive ratio session0.00.00.10.1-0.2-0.20.2-0.20.30.20.2
Number of licking bursts0.10.10.30.5-0.3-0.30.2-0.20.40.10.2
Context. condit. distance diff. score0.60.72.71.7-0.4-0.1-0.50.50.2-1.0-1.0
Locomotion velocity, session 10.10.10.2-0.1-0.2-0.20.3-0.30.30.40.4
Locomotion distance, session 10.50.72.3-1.51.00.8-0.50.5-0.8-0.2-0.2
Locomotion velocity, session 20.20.30.9-1.00.60.5-0.40.4-0.5-0.2-0.1
Locomotion distance, session 20.91.24.7-2.21.31.1-0.60.6-1.0-0.2-0.1
Locomotion velocity, session 31.21.43.11.8-1.3-1.21.0-1.01.30.70.7
Locomotion distance, session 30.10.10.70.8-0.3-0.20.0-0.00.3-0.2-0.2
Stereotopy head waving bouts, day 30.50.60.80.5-0.7-0.70.8-0.80.80.80.9
Stereotopy head waving duration, day 31.92.33.10.8-1.4-1.51.6-1.61.61.71.8
Locomotion velocity, session 72.22.45.51.10.61.0-1.61.6-1.0-2.3-2.3
Locomotion distance, session 71.72.24.50.60.81.1-1.61.6-1.1-2.1-2.1
Stereotopy head waving bouts, day 71.11.21.90.4-0.9-1.01.2-1.21.11.41.3
Stereotopy head waving duration, day 71.92.33.10.9-1.4-1.51.6-1.61.51.81.7
Locomotion velocity, session 80.10.10.50.7-0.4-0.30.1-0.10.3-0.1-0.1
Locomotion distance, session 80.50.70.9-0.50.80.8-0.90.9-0.8-1.0-0.9
Degree of sensitization distance2.92.94.8-0.41.41.6-1.91.9-1.5-2.2-2.2
Degree of sensitization stereotypy0.91.01.30.6-0.9-1.01.1-1.10.91.21.1
Conditioned locomotion0.00.10.30.5-0.2-0.1-0.00.00.0-0.2-0.2
Cocaine response after cond. corrected1.21.43.71.9-1.4-1.30.9-0.91.30.50.6
Cocaine response after cond. not corrected0.60.71.51.2-1.0-0.90.7-0.70.80.40.4
Cocaine response before conditioning0.91.13.2-1.81.21.1-0.70.7-1.2-0.4-0.5
Saline control response0.50.71.2-1.10.90.9-0.70.7-0.9-0.5-0.5
Bone: connectivity density2.53.94.3-1.52.02.0-2.12.1-2.0-2.1-2.0
Bone: cortical apparent density0.50.73.51.9-0.9-0.70.3-0.30.6-0.2-0.3
Bone: cortical area0.00.00.1-0.40.30.2-0.10.1-0.3-0.1-0.1
Bone: cortical porosity0.70.71.6-0.5-0.4-0.60.9-0.90.51.31.2
Bone: cortical porosity0.30.30.8-0.90.1-0.10.5-0.50.10.80.8
Bone: cortical thickness0.00.00.1-0.00.10.1-0.20.2-0.3-0.2-0.3
Bone: cortical thickness0.10.10.60.8-0.4-0.30.0-0.00.2-0.2-0.3
Bone: cortical tissue density0.60.73.71.9-1.0-0.70.3-0.30.6-0.2-0.3
Condit. Reinf. active minus inactive responses0.20.20.6-0.2-0.2-0.30.5-0.50.40.60.8
Condit. Reinf. active-inactive response ratio2.12.32.51.3-1.6-1.61.6-1.61.51.51.4
Condit. Reinf. active responses0.30.31.5-1.20.70.6-0.30.3-0.4-0.00.2
Condit. Reinf. inactive responses4.75.68.6-2.92.72.5-2.22.2-2.5-1.8-1.8
Incentive salience index mean0.30.41.0-0.7-0.1-0.30.6-0.60.40.91.0
Condit. Reinf. lever presses0.30.41.9-1.40.40.20.2-0.2-0.20.50.6
Condit. Reinf. active minus inactive responses0.30.40.5-0.50.60.6-0.60.6-0.7-0.6-0.7
Condit. Reinf. active-inactive response ratio0.30.30.50.7-0.7-0.60.5-0.50.50.40.3
Condit. Reinf. active responses0.91.31.5-1.01.21.2-1.11.1-1.2-1.1-1.2
Condit. Reinf. inactive responses2.73.33.8-1.81.91.9-1.81.8-1.9-1.7-1.7
Condit. Reinf. lever presses0.60.82.4-1.51.10.9-0.60.6-1.0-0.3-0.3
Condit. Reinf. lever reinforcers received0.70.91.1-0.91.01.0-1.01.0-1.1-0.9-0.9
Conditioned reinforcement - actives1.81.82.9-0.31.01.2-1.41.4-1.3-1.7-1.7
Conditioned reinforcement - inactives3.23.64.1-1.72.02.0-2.02.0-1.9-1.8-1.8
Conditioned locomotion0.81.01.2-0.70.91.0-1.01.0-1.0-1.1-1.1
Patch foraging indifference point 0 sec4.26.812.9-3.63.22.9-2.42.4-2.4-1.8-1.5
Patch foraging indifference point AUC0.91.01.71.3-1.2-1.10.9-0.91.00.70.7
Delay disc. indifference point, 0s delay0.91.02.1-1.41.21.1-0.90.9-0.9-0.7-0.5
Delay disc. indifference point, 16s delay0.20.20.3-0.60.50.5-0.50.5-0.4-0.4-0.5
Delay disc. indifference point, 2s delay0.91.01.80.1-0.7-0.81.1-1.11.01.31.3
Delay disc. indifference point, 24s delay0.40.40.60.8-0.7-0.60.5-0.50.70.50.4
Delay disc. indifference point, 4s delay1.51.51.70.9-1.3-1.31.3-1.31.31.21.2
Delay disc. indifference point, 8s delay0.10.10.3-0.50.30.3-0.30.3-0.2-0.2-0.2
Indifference point function ln k0.30.41.5-1.20.80.6-0.40.4-0.8-0.1-0.2
Indifference point function log k0.30.41.5-1.20.80.6-0.40.4-0.8-0.1-0.2
Patch foraging total patch changes 0 sec3.76.011.9-3.43.02.7-2.22.2-2.3-1.6-1.4
Patch foraging total patch changes 12 sec1.51.93.9-2.01.71.6-1.31.3-1.2-1.0-0.7
Patch foraging total patch changes 18 sec2.12.73.4-1.61.81.8-1.81.8-1.4-1.6-1.3
Patch foraging total patch changes 24 sec0.50.62.0-1.41.00.8-0.40.4-0.9-0.0-0.2
Patch foraging total patch changes 6 sec0.30.50.7-0.80.90.8-0.80.8-0.3-0.7-0.3
Patch foraging time to switch 0 sec0.50.81.1-0.60.91.0-1.01.0-0.6-1.0-0.8
Patch foraging water rate 0 sec0.20.30.6-0.2-0.3-0.40.6-0.60.40.80.7
Patch foraging water rate 12 sec0.30.50.90.1-0.5-0.70.8-0.80.31.00.8
Patch foraging water rate 18 sec2.93.94.61.8-2.1-2.12.1-2.11.72.01.7
Patch foraging water rate 24 sec0.30.51.41.2-0.8-0.80.6-0.60.50.40.2
Patch foraging water rate 6 sec1.11.63.00.2-1.0-1.21.5-1.50.81.71.5
Seeking ratio, delayed vs. immediate footshock1.21.41.7-1.21.31.3-1.21.2-1.2-1.0-1.1
Distance traveled before self-admin0.50.51.3-0.6-0.3-0.40.8-0.80.51.11.1
Distance traveled after self-admin2.42.73.11.4-1.7-1.71.7-1.71.61.61.5
Extensor digitorum longus weight11.746.251.55.0-6.8-6.97.1-7.16.97.17.2
Bone: elastic displacement1.31.52.6-1.61.41.3-1.11.1-1.4-0.8-1.0
Bone: elastic work1.51.95.0-2.21.61.4-1.01.0-1.6-0.6-0.8
Bone: endosteal estimation0.10.20.4-0.2-0.2-0.30.4-0.40.40.50.6
Bone: endosteal perimeter0.10.10.4-0.60.20.00.2-0.20.00.40.5
Epididymis fat weight1.63.75.1-1.42.02.1-2.22.2-1.4-2.3-1.7
Delta time in closed arm before/after self-admin2.92.83.6-1.71.91.8-1.71.7-1.7-1.5-1.4
Delta time in open arm before/after self-admin0.00.00.10.3-0.1-0.1-0.00.00.0-0.0-0.2
Diff in mean of infusions in LGA sessions2.73.03.21.4-1.8-1.81.8-1.81.81.71.7
Delay discount exponential model param0.10.10.20.00.30.3-0.40.4-0.4-0.5-0.4
Extinction: sum of active levers before priming2.02.02.8-0.71.31.4-1.51.5-1.4-1.7-1.6
Active lever presses in extinction session 60.20.20.50.00.30.4-0.50.5-0.4-0.6-0.7
Bone: final force0.10.10.20.3-0.3-0.40.4-0.40.30.40.3
Bone: final moment0.00.00.1-0.2-0.1-0.10.3-0.30.00.40.3
Food consumed during 24 hour testing period0.60.81.8-1.31.11.0-0.70.7-0.9-0.5-0.4
Glucose0.10.21.11.1-0.4-0.30.1-0.10.5-0.2-0.1
Heart weight0.10.10.4-0.60.40.3-0.20.20.1-0.00.2
Delay discount hyperbolic model param0.30.30.5-0.00.50.5-0.60.6-0.6-0.7-0.7
Intermittent access intake day 1-15 change1.91.92.1-1.11.41.4-1.51.5-1.3-1.4-1.4
Intermittent access intake escalation1.11.11.3-0.71.11.1-1.11.1-1.0-1.1-1.1
Intermittent access intake escalation 20.30.30.4-0.50.50.6-0.60.6-0.6-0.6-0.6
Intermitt. access day 1 inactive lever presses0.10.10.1-0.20.20.2-0.20.2-0.2-0.3-0.3
Intermitt. access day 15 inactive lever presses0.10.10.3-0.50.50.4-0.30.3-0.3-0.1-0.0
Intermitt. access escalation Index0.60.50.60.8-0.8-0.80.7-0.70.80.60.6
Intermittent access day 1 total infusions0.00.00.0-0.00.10.1-0.20.2-0.2-0.2-0.2
Intermittent access day 15 total infusions0.70.81.1-0.40.80.9-1.01.0-0.9-1.0-1.0
Intermittent access terminal intake (last 3 days)0.10.10.20.20.10.2-0.30.3-0.3-0.4-0.5
Intermittent access total infusions0.20.20.50.10.30.4-0.50.5-0.5-0.7-0.7
Intermittent access day 1 locomotion0.40.50.6-0.70.80.8-0.70.7-0.7-0.6-0.5
Intermittent access day 15 total locomotion1.11.21.6-0.51.01.1-1.21.2-1.1-1.3-1.3
Intermittent access total locomotion0.40.50.5-0.60.70.7-0.70.7-0.7-0.7-0.7
Intermittent access standard deviation1.31.41.6-1.11.31.3-1.21.2-1.2-1.1-1.1
Left kidney weight0.20.61.10.1-0.5-0.60.8-0.80.71.11.0
Right kidney weight0.30.92.7-1.61.21.1-0.80.8-0.2-0.40.2
Cocaine induced anxiety0.40.42.3-1.50.70.5-0.00.0-0.30.40.5
Post-drug Anxiety1.01.12.1-1.41.31.2-1.01.0-1.0-0.7-0.6
Baseline Anxiety0.50.50.9-0.10.60.6-0.80.8-0.7-0.9-1.0
Tail length1.13.44.6-2.02.12.1-1.91.9-1.6-1.7-1.3
Length with tail0.10.30.9-0.90.30.10.2-0.20.40.60.9
Length without tail3.06.69.31.2-2.3-2.52.7-2.72.63.13.0
Times rat made contact with spout0.30.30.5-0.10.50.5-0.60.6-0.5-0.7-0.7
Lifetime Intake0.20.30.50.00.40.4-0.60.6-0.5-0.7-0.7
Liver weight, left1.93.13.81.1-1.7-1.81.9-1.91.81.92.0
Liver weight, right0.81.31.51.0-1.2-1.21.2-1.21.21.11.2
Locomotor activity0.71.13.5-1.90.3-0.10.9-0.9-0.31.61.2
Locomotor testing distance1.42.38.7-3.01.71.4-0.70.7-2.0-0.0-0.5
Locomotor testing rearing2.74.213.8-3.72.62.2-1.41.4-2.1-0.6-0.5
Locomotion in novel chamber0.40.51.1-1.10.80.8-0.70.7-0.7-0.4-0.4
Locomotion in novel chamber post-restriction0.70.80.90.8-0.9-0.90.9-0.90.90.90.9
Fecal boli incidents, locomotor time 10.50.50.80.3-0.6-0.70.8-0.80.70.90.9
Change in fecal boli incidents, locomotor task0.20.20.30.5-0.6-0.50.4-0.40.40.30.3
Time >=10cm from walls, locomotor time 11.31.31.6-1.31.21.2-1.11.1-1.2-1.0-1.0
Bouts of movement, locomotor time 15.05.56.22.0-2.5-2.52.4-2.42.32.22.3
Total resting periods, locomotor time 15.56.07.32.4-2.7-2.62.5-2.52.42.22.2
Rest time, locomotor task time 13.33.64.11.6-2.0-2.02.0-2.01.91.81.8
Distance moved, locomotor task time 13.03.33.7-1.41.81.9-1.91.9-1.8-1.7-1.9
Vertical activity count, locomotor time 11.92.03.6-1.91.71.6-1.31.3-1.4-0.9-0.9
Time >=10cm from walls, locomotor time 20.30.30.50.4-0.5-0.50.6-0.60.50.70.6
Bouts of movement, locomotor time 24.44.85.72.2-2.4-2.32.2-2.22.31.92.0
Total resting periods, locomotor time 25.35.76.82.4-2.6-2.52.4-2.42.52.12.1
Rest time, locomotor task time 22.02.33.41.8-1.8-1.71.5-1.51.51.21.1
Distance moved, locomotor task time 24.14.76.1-2.42.52.4-2.12.1-2.2-1.7-1.7
Vertical activity count, locomotor time 21.21.33.0-1.71.51.3-1.01.0-1.1-0.6-0.5
Light reinforcement 12.54.67.3-0.91.82.0-2.32.3-2.2-2.5-2.7
Light reinforcement 20.50.71.70.90.10.4-0.90.90.1-1.3-1.0
Bone: marrow area0.00.10.2-0.3-0.1-0.10.3-0.30.30.40.5
Bone: maximum diameter0.40.70.70.7-0.8-0.80.8-0.80.90.80.8
Bone: maximum force0.10.20.4-0.1-0.3-0.30.5-0.50.30.60.6
Bone: maximum moment0.10.10.4-0.70.10.00.2-0.2-0.10.40.4
Mean time between licks in bursts2.33.23.8-1.71.91.9-1.81.8-1.9-1.7-1.7
Mean num. licks in bursts0.40.50.6-0.60.60.7-0.70.7-0.8-0.7-0.7
Cd content in liver0.20.20.4-0.20.40.5-0.50.5-0.5-0.6-0.6
Co content in liver5.05.87.02.6-2.6-2.62.4-2.42.52.12.0
Cu content in liver0.60.70.90.8-0.9-0.90.9-0.81.00.80.8
Fe content in liver1.92.32.6-1.21.61.6-1.61.6-1.5-1.6-1.5
K content in liver0.40.40.6-0.20.50.6-0.70.7-0.6-0.8-0.7
Mg content in liver0.80.91.3-0.30.80.9-1.01.0-0.8-1.1-1.1
Mn content in liver2.02.32.5-1.31.51.6-1.61.6-1.5-1.5-1.5
Na content in liver0.60.73.2-1.80.60.30.3-0.3-0.30.80.9
Rb content in liver0.10.20.70.8-0.2-0.0-0.30.30.2-0.5-0.4
Se content in liver2.93.68.2-2.92.22.0-1.61.5-2.1-1.0-1.1
Sr content in liver0.60.60.7-0.80.80.8-0.70.7-0.8-0.7-0.7
Zn content in liver0.40.51.1-0.8-0.1-0.30.7-0.70.21.01.0
Bone: minimum diameter0.10.20.6-0.80.10.00.3-0.3-0.10.50.5
Time in familiar zone, hab. session 10.10.10.20.5-0.4-0.40.3-0.30.50.20.2
Time in novel zone, hab. session 11.61.62.21.5-1.4-1.31.2-1.21.31.11.0
Total zone transitions, hab. session 10.10.10.3-0.60.1-0.00.2-0.20.10.50.5
Total locomotion distance, hab. session 10.30.51.8-1.30.90.7-0.40.4-0.6-0.1-0.0
Locomotion velocity, hab. session 11.01.44.5-2.11.51.3-0.80.8-1.3-0.4-0.4
Time in familiar zone, hab. session 23.94.16.32.5-2.3-2.11.8-1.82.31.41.6
Time in novel zone, hab. session 21.61.62.5-1.61.41.3-1.11.1-1.4-0.9-1.0
Total zone transitions, hab. session 20.60.81.8-0.6-0.3-0.61.0-1.00.61.31.3
Total locomotion distance, hab. session 20.10.20.6-0.80.20.00.3-0.30.10.50.6
Locomotion velocity, hab. session 20.30.40.9-0.80.1-0.10.5-0.50.20.80.9
Novel to familiar place preference ratio2.22.32.7-1.61.71.6-1.51.5-1.6-1.3-1.3
Novelty place preference1.81.82.2-1.51.51.4-1.31.3-1.5-1.1-1.2
Time in novel zone, NPP test1.01.01.4-1.21.11.1-1.01.0-1.1-0.8-0.8
Total zone transitions, NPP test0.81.13.0-1.71.31.1-0.80.8-1.0-0.5-0.4
Total locomotion distance, NPP test4.25.78.5-2.92.72.6-2.32.3-2.4-1.9-1.7
Locomotion velocity, NPP test3.95.68.3-2.92.72.6-2.32.3-2.4-1.9-1.7
Intraocular pressure0.81.11.8-0.91.01.0-1.01.0-1.4-0.9-1.2
Delta distance traveled before/after self-admin4.14.57.02.7-2.5-2.32.0-2.02.21.61.4
Delta ambulatory time before/after self-admin3.53.85.62.4-2.3-2.11.9-1.92.01.61.4
Parametrial fat weight2.65.06.7-1.62.32.4-2.52.5-1.7-2.6-2.0
Pavlov. Cond. lever latency0.10.20.80.9-0.5-0.40.2-0.20.40.0-0.1
Pavlov. Cond. magazine entry latency0.00.10.1-0.20.30.3-0.30.3-0.3-0.2-0.3
Pavlov. Cond. change in total contacts0.50.61.1-0.1-0.5-0.60.8-0.80.61.01.0
Pavlov. Cond. index score0.00.00.2-0.40.10.00.1-0.1-0.10.30.2
Pavlov. Cond. latency score0.10.10.4-0.60.30.2-0.00.0-0.20.10.1
Pavlov. Cond. lever contacts0.20.20.9-0.90.60.5-0.30.3-0.4-0.10.0
Pavlov. Cond. magazine entry number0.30.40.5-0.40.60.6-0.70.7-0.6-0.7-0.7
Pavlov. Cond. intertrial magazine entries0.50.61.9-1.40.90.8-0.60.6-0.7-0.3-0.2
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.3-0.0-0.10.3-0.30.10.40.4
Pavlov. Cond. response bias0.10.10.2-0.1-0.2-0.20.3-0.30.20.40.4
Pavlov. Cond. lever latency0.20.20.70.9-0.20.0-0.40.4-0.0-0.7-0.7
Pavlov. Cond. magazine entry latency0.40.51.4-1.20.90.8-0.50.5-0.7-0.3-0.3
Pavlov. Cond. change in total contacts0.91.22.3-0.0-0.8-0.91.2-1.21.01.51.5
Pavlov. Cond. index score0.20.30.7-0.90.1-0.10.4-0.40.10.80.8
Pavlov. Cond. latency score0.20.31.1-1.10.30.10.2-0.2-0.10.60.6
Pavlov. Cond. lever contacts0.20.31.4-1.20.30.10.3-0.3-0.10.70.7
Pavlov. Cond. magazine entry number0.30.30.80.9-0.7-0.60.4-0.40.50.20.2
Pavlov. Cond. intertrial magazine entries5.77.48.1-2.12.72.8-2.82.8-2.8-2.8-2.8
Pavlov. Cond. lever-magazine prob. diff.0.30.30.8-0.6-0.0-0.20.5-0.50.30.90.9
Pavlov. Cond. response bias0.30.41.4-1.20.30.10.4-0.4-0.00.80.8
Time in closed arm before self-admin2.52.83.51.6-1.9-1.81.7-1.71.71.61.4
Time in closed arm after self-admin0.50.60.60.5-0.7-0.80.8-0.80.80.80.8
Time in open arm before self-admin0.00.00.10.0-0.0-0.10.2-0.20.20.20.4
Time in open arm after self-admin0.10.10.1-0.40.40.4-0.30.3-0.4-0.3-0.3
Bone: periosteal estimation0.00.00.1-0.30.0-0.00.2-0.20.10.30.3
Bone: periosteal perimeter0.00.00.1-0.40.10.10.0-0.0-0.10.10.1
Bone: post-yield work0.10.10.20.5-0.10.0-0.20.20.0-0.4-0.3
Progressive ratio test 1 active lever presses1.01.03.01.7-1.3-1.10.8-0.81.00.50.3
Progressive ratio test 1 breakpoint0.80.92.81.7-1.2-1.00.7-0.70.80.30.2
Progressive ratio test 1 inactive lever presses1.21.31.8-0.51.01.1-1.21.2-1.1-1.3-1.4
Progressive ratio test 2 active lever presses0.30.31.41.2-0.4-0.3-0.10.10.1-0.5-0.6
Progressive ratio test 2 breakpoint0.20.20.50.7-0.10.0-0.30.3-0.1-0.5-0.6
Progressive ratio test 2 inactive lever presses0.30.30.4-0.30.60.6-0.60.6-0.6-0.7-0.7
Incentive Sensitization - Responses0.70.81.1-0.30.80.8-0.90.9-0.9-1.0-1.0
Incentive Sensitization - Breakpoint1.11.21.5-0.61.01.1-1.21.2-1.1-1.2-1.2
Sum of active levers in priming session hrs 5-60.20.20.90.9-0.4-0.2-0.00.00.2-0.4-0.3
Progressive ratio0.10.10.2-0.00.30.3-0.30.3-0.2-0.4-0.4
Food seeking constrained by brief footshock3.54.39.63.1-2.5-2.31.8-1.82.11.31.1
Seeking ratio, punishment vs. effort1.51.92.81.7-1.6-1.51.3-1.31.31.11.0
Retroperitoneal fat weight0.10.20.30.50.10.2-0.50.50.5-0.6-0.1
Reaction time number correct0.91.31.81.4-1.3-1.21.1-1.11.01.00.8
Reaction time mean minus median0.10.10.3-0.40.1-0.10.3-0.3-0.00.50.4
Reaction time mean minus median AUC0.00.10.2-0.2-0.0-0.10.3-0.30.00.40.3
Reaction time num false alarms0.00.00.10.0-0.1-0.10.2-0.20.00.40.1
Reaction time num false alarms AUC0.00.00.0-0.00.10.00.0-0.0-0.10.2-0.1
Reaction time trials correct on left0.91.31.81.4-1.3-1.21.1-1.11.01.00.8
Reaction time trials on left0.71.01.61.3-1.2-1.11.0-1.00.90.80.6
Reaction time mean0.10.10.2-0.1-0.1-0.20.3-0.30.20.40.4
Reaction time mean AUC0.10.20.4-0.1-0.2-0.30.5-0.50.20.60.5
Median of all reaction times0.00.10.10.1-0.0-0.10.2-0.20.40.30.4
Reaction time omissions2.23.03.9-1.11.71.7-1.81.8-1.9-1.7-2.0
Reaction time false alarm rate0.20.20.4-0.50.50.5-0.40.4-0.6-0.3-0.5
Reaction time premature initiation rate2.02.63.92.0-1.9-1.81.6-1.61.61.31.1
Reaction time premature initiations3.14.46.72.6-2.4-2.32.0-2.02.01.71.4
Std. dev. reaction times0.10.10.2-0.3-0.0-0.10.3-0.3-0.20.50.2
Reaction time trials completed0.71.01.61.3-1.2-1.11.0-1.00.90.80.6
Reaction time trials AUC0.60.91.51.2-1.1-1.10.9-0.90.80.80.6
Run reversals in cocaine runway, females4.24.14.5-1.62.12.1-2.12.1-2.0-2.1-2.0
Run reversals in cocaine runway, males2.12.02.40.9-1.4-1.51.5-1.51.41.51.5
Latency to leave start box in cocaine runway0.60.60.70.6-0.7-0.80.8-0.80.70.80.8
Latency to leave start box in cocaine runway, F1.11.31.70.7-1.0-1.11.2-1.21.01.31.3
Latency to leave start box in cocaine runway, M1.21.21.3-0.91.11.2-1.11.1-1.0-1.1-1.1
Std. dev. time between licks in bursts3.23.87.2-2.72.22.1-1.71.7-2.1-1.3-1.3
Total sessions with >9 infusions0.10.10.40.6-0.3-0.20.0-0.00.1-0.1-0.2
Short access day 1 total inactive lever presses0.40.40.6-0.30.60.7-0.70.7-0.7-0.8-0.8
Short access day 10 total inactive lever presses0.30.30.4-0.20.40.5-0.60.6-0.5-0.6-0.7
Short access day 1 total infusions0.60.72.01.4-1.1-0.90.6-0.60.70.30.2
Short access day 10 total infusions0.10.10.3-0.60.50.4-0.30.3-0.4-0.2-0.1
Short access total infusions0.10.10.2-0.10.30.3-0.40.4-0.4-0.5-0.5
Short access day 1 locomotion0.10.10.3-0.1-0.2-0.30.4-0.40.30.50.5
Short access day 10 total locomotion0.80.91.2-1.01.11.0-0.90.9-0.9-0.8-0.7
Short access total locomotion1.01.11.5-1.21.21.1-1.01.0-1.0-0.9-0.8
One hour access (0.3 mA shock)0.30.30.4-0.50.60.6-0.60.6-0.5-0.5-0.5
Compulsive drug intake0.10.10.6-0.70.40.3-0.10.1-0.20.10.2
One hour access (shock baseline)0.00.00.10.3-0.2-0.10.1-0.10.10.0-0.0
Social response proportion1.11.23.41.9-1.4-1.20.7-0.71.30.40.4
Social responses0.70.91.4-0.40.80.9-1.11.1-0.8-1.2-1.1
Social time0.71.01.9-1.41.21.1-0.90.9-1.0-0.6-0.7
Soleus weight1.23.54.51.8-1.9-1.91.8-1.82.11.71.9
Bone: stiffness0.60.91.10.8-0.9-0.91.0-1.01.01.01.0
Tibialis anterior weight7.224.530.33.2-4.7-5.05.2-5.25.15.35.5
Time to tail flick, vehicle, before self-admin0.80.80.9-0.81.01.0-1.01.0-0.9-0.8-0.9
Time to tail flick, vehicle, after self-admin2.93.14.52.1-2.0-1.91.7-1.71.81.41.3
Time to tail flick, test, before self-admin1.41.31.9-1.21.41.3-1.11.1-1.2-1.0-0.9
Time to tail flick, test, after self-admin1.92.03.7-0.11.01.2-1.61.6-1.4-1.8-1.9
Delta time to tail flick, vehicle, before/after SA0.90.92.21.5-1.2-1.10.8-0.80.90.50.5
Delta time to tail flick, test, before/after SA0.40.31.51.2-0.6-0.4-0.10.10.1-0.4-0.6
Tibia length2.77.615.5-3.93.23.0-2.42.4-2.9-1.8-1.7
Ambulatory time before self-admin0.30.30.7-0.5-0.2-0.30.5-0.50.30.80.9
Ambulatory time after self-admin3.63.94.31.5-2.0-2.12.1-2.12.02.02.0
Bone: tissue strength0.20.20.4-0.60.50.5-0.40.4-0.4-0.3-0.2
Total heroin consumption0.20.20.4-0.1-0.3-0.40.5-0.50.40.70.7
Bone: trabecular number2.53.94.3-1.72.12.1-2.02.0-2.0-2.0-1.9
Bone: trabecular spacing2.22.83.21.3-1.7-1.81.8-1.81.61.81.6
Bone: trabecular thickness1.41.72.1-1.31.51.4-1.41.4-1.2-1.2-1.1
Bone: trabecular tissue density0.91.21.70.5-1.0-1.11.2-1.21.01.31.2
Water consumed over 24 hours0.91.11.70.5-0.9-1.01.2-1.21.01.31.3
Number of responses in last shaping day0.00.00.2-0.50.20.2-0.10.1-0.10.00.1