Hub : Genes

Fibp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Fibp	0.07	0.04	4.4e-11	0.08	0.08	0.08	0.07	5.5e-12	1.0e-11	1.3e-11	3.9e-11
2	Brain	mRNA stability	Fibp	0.04	0.02	8.1e-04	0.01	0.02	0.02	0.03	1.5e-02	2.4e-03	2.7e-03	1.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.3	0.5	0.9	-1.0	-0.4
Area under the delay curve	0.3	0.3	0.6	0.3	-0.7
BMI with tail	0.9	3.2	6.2	-2.5	0.5
BMI without tail	0.5	1.4	2.7	-1.6	0.3
Body weight	2.3	9.9	13.2	-3.6	2.6
Weight adjusted by age	1.7	2.6	3.0	-1.4	1.7
Bone surface	3.4	6.1	9.6	-3.1	1.6
Bone volume	1.0	1.8	3.4	-1.8	0.5
Breakpoint value in progressive ratio session	3.4	4.0	4.9	-2.2	1.8
Number of licking bursts	0.3	0.5	0.6	-0.8	0.6
Context. condit. distance diff. score	2.4	2.9	3.3	1.8	-1.6
Locomotion velocity, session 1	0.1	0.1	0.2	0.0	0.4
Locomotion distance, session 1	0.2	0.3	0.6	-0.8	0.0
Locomotion velocity, session 2	2.7	3.1	4.0	-2.0	1.5
Locomotion distance, session 2	0.5	0.7	1.1	-1.0	0.5
Locomotion velocity, session 3	0.2	0.3	0.4	0.3	-0.7
Locomotion distance, session 3	0.0	0.0	0.0	0.1	-0.0
Stereotopy head waving bouts, day 3	1.4	1.6	2.0	1.1	-1.4
Stereotopy head waving duration, day 3	1.8	2.1	2.6	1.3	-1.6
Locomotion velocity, session 7	0.5	0.6	0.9	0.5	-0.9
Locomotion distance, session 7	0.0	0.0	0.1	0.1	-0.3
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	0.1	-0.7
Stereotopy head waving duration, day 7	0.3	0.4	0.8	-0.9	0.1
Locomotion velocity, session 8	1.1	1.3	1.4	-1.1	1.2
Locomotion distance, session 8	0.4	0.5	0.6	0.7	-0.8
Degree of sensitization distance	0.1	0.1	0.1	0.0	-0.3
Degree of sensitization stereotypy	0.3	0.4	0.6	-0.8	0.3
Conditioned locomotion	1.9	2.2	2.5	-1.4	1.6
Cocaine response after cond. corrected	1.1	1.3	1.8	1.3	-1.0
Cocaine response after cond. not corrected	0.9	1.0	1.3	1.1	-0.9
Cocaine response before conditioning	0.7	0.8	1.0	-1.0	0.7
Saline control response	3.9	5.2	6.5	-2.6	2.0
Bone: connectivity density	1.6	2.5	4.5	-2.1	0.7
Bone: cortical apparent density	0.2	0.3	0.5	-0.4	0.7
Bone: cortical area	1.1	1.8	1.8	-1.3	1.3
Bone: cortical porosity	0.1	0.1	0.1	-0.3	-0.2
Bone: cortical porosity	0.2	0.2	0.4	-0.7	0.2
Bone: cortical thickness	5.1	8.5	10.1	-2.6	3.2
Bone: cortical thickness	1.3	1.5	2.0	-1.0	1.4
Bone: cortical tissue density	0.4	0.5	0.8	-0.5	0.9
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.5	0.4
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.1	0.2
Condit. Reinf. active responses	0.1	0.1	0.2	-0.4	0.4
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.0	-0.2
Incentive salience index mean	0.3	0.4	0.5	-0.7	0.5
Condit. Reinf. lever presses	0.5	0.7	0.7	-0.9	0.8
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.1	-0.7
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.0	0.7	-1.0
Condit. Reinf. active responses	0.2	0.3	0.3	-0.5	-0.6
Condit. Reinf. inactive responses	0.3	0.4	0.7	-0.8	-0.1
Condit. Reinf. lever presses	1.9	2.6	4.0	-2.0	1.1
Condit. Reinf. lever reinforcers received	0.2	0.3	0.6	-0.8	-0.3
Conditioned reinforcement - actives	0.0	0.0	0.0	-0.1	0.1
Conditioned reinforcement - inactives	2.1	3.1	3.4	1.8	-1.7
Conditioned locomotion	7.1	9.2	10.8	3.3	-2.8
Patch foraging indifference point 0 sec	0.1	0.2	0.3	0.3	-0.5
Patch foraging indifference point AUC	2.7	3.8	4.1	-2.0	1.9
Delay disc. indifference point, 0s delay	1.3	1.4	1.8	1.0	-1.4
Delay disc. indifference point, 16s delay	0.8	0.9	1.1	0.8	-1.1
Delay disc. indifference point, 2s delay	0.2	0.3	0.5	0.1	-0.7
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.5	0.0
Delay disc. indifference point, 4s delay	0.4	0.4	0.6	0.4	-0.8
Delay disc. indifference point, 8s delay	0.2	0.3	0.4	0.5	-0.6
Indifference point function ln k	6.5	11.3	13.6	3.7	-3.0
Indifference point function log k	6.5	11.3	13.6	3.7	-3.0
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	0.2	-0.1
Patch foraging total patch changes 12 sec	4.3	5.6	7.4	-2.7	1.9
Patch foraging total patch changes 18 sec	0.5	0.7	1.1	-1.0	0.6
Patch foraging total patch changes 24 sec	1.6	2.8	2.9	-1.6	1.7
Patch foraging total patch changes 6 sec	1.1	1.6	2.3	-1.5	1.0
Patch foraging time to switch 0 sec	0.7	1.4	2.4	-1.6	0.6
Patch foraging water rate 0 sec	2.2	4.6	7.3	2.7	-1.4
Patch foraging water rate 12 sec	5.2	11.0	15.5	3.9	-2.5
Patch foraging water rate 18 sec	2.1	3.2	4.2	2.1	-1.5
Patch foraging water rate 24 sec	3.5	4.9	7.5	2.7	-1.5
Patch foraging water rate 6 sec	2.7	3.9	6.3	2.5	-1.2
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.4	0.3	-0.6
Distance traveled before self-admin	0.3	0.4	0.8	-0.9	0.2
Distance traveled after self-admin	0.1	0.1	0.2	-0.5	0.2
Extensor digitorum longus weight	8.3	32.7	35.2	-5.9	5.5
Bone: elastic displacement	0.3	0.4	0.7	0.9	0.2
Bone: elastic work	1.9	2.4	3.3	-1.2	1.8
Bone: endosteal estimation	1.4	3.1	4.2	1.4	-2.1
Bone: endosteal perimeter	1.9	4.0	5.7	1.5	-2.4
Epididymis fat weight	3.7	12.5	13.6	3.7	-3.4
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	-0.4	0.5
Delta time in open arm before/after self-admin	0.1	0.1	0.1	-0.3	0.3
Diff in mean of infusions in LGA sessions	1.0	1.3	1.5	-1.2	1.0
Delay discount exponential model param	0.2	0.2	0.3	-0.2	0.6
Extinction: sum of active levers before priming	2.4	2.6	3.9	-2.0	1.1
Active lever presses in extinction session 6	3.4	3.4	3.6	-1.9	1.8
Bone: final force	2.4	3.8	4.6	-2.1	1.7
Bone: final moment	2.1	3.4	4.2	-2.1	1.6
Food consumed during 24 hour testing period	0.1	0.1	0.1	-0.2	0.4
Glucose	3.4	5.4	6.2	2.1	-2.5
Heart weight	2.0	3.1	4.2	1.4	-2.1
Delay discount hyperbolic model param	0.2	0.2	0.4	-0.2	0.6
Intermittent access intake day 1-15 change	0.5	1.1	1.7	1.3	-0.7
Intermittent access intake escalation	0.4	0.8	1.4	1.2	-0.5
Intermittent access intake escalation 2	0.8	0.9	1.5	1.2	-0.6
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	0.5	-0.2
Intermitt. access day 15 inactive lever presses	0.8	1.6	1.8	1.2	-1.3
Intermitt. access escalation Index	3.3	4.6	5.5	2.0	-2.3
Intermittent access day 1 total infusions	3.3	5.4	7.9	1.7	-2.8
Intermittent access day 15 total infusions	4.2	6.3	6.7	2.4	-2.6
Intermittent access terminal intake (last 3 days)	4.4	5.8	6.8	2.2	-2.6
Intermittent access total infusions	3.9	4.6	6.2	1.7	-2.5
Intermittent access day 1 locomotion	2.8	3.5	4.8	1.5	-2.2
Intermittent access day 15 total locomotion	2.7	4.9	5.7	2.1	-2.4
Intermittent access total locomotion	7.4	8.8	10.7	2.6	-3.3
Intermittent access standard deviation	0.6	1.3	1.8	1.3	-0.9
Left kidney weight	1.0	4.6	4.9	2.1	-2.2
Right kidney weight	0.4	1.8	2.1	1.4	-1.2
Cocaine induced anxiety	0.0	0.0	0.0	-0.1	0.1
Post-drug Anxiety	0.6	0.6	0.7	-0.8	0.8
Baseline Anxiety	0.3	0.3	0.4	-0.6	0.5
Tail length	0.5	2.1	2.9	-1.2	1.7
Length with tail	2.1	9.2	10.1	-2.9	3.2
Length without tail	2.4	7.7	8.3	-2.6	2.9
Times rat made contact with spout	0.4	0.4	0.7	-0.8	0.5
Lifetime Intake	2.9	3.5	4.9	1.4	-2.2
Liver weight, left	0.8	1.3	1.8	1.3	-0.9
Liver weight, right	2.0	3.5	4.6	2.2	-1.5
Locomotor activity	1.0	1.6	2.5	1.6	-0.8
Locomotor testing distance	1.2	2.1	3.3	1.8	-1.0
Locomotor testing rearing	1.4	2.9	2.9	1.7	-1.7
Locomotion in novel chamber	5.3	6.8	7.8	2.8	-2.4
Locomotion in novel chamber post-restriction	2.4	3.9	4.0	1.9	-2.0
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	-0.2	0.0
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.2	-0.3
Time >=10cm from walls, locomotor time 1	1.4	1.5	2.2	0.9	-1.5
Bouts of movement, locomotor time 1	1.6	1.8	2.2	-1.2	1.5
Total resting periods, locomotor time 1	1.0	1.1	1.2	-1.0	1.1
Rest time, locomotor task time 1	1.1	1.4	1.7	1.3	-1.0
Distance moved, locomotor task time 1	0.1	0.1	0.1	-0.4	-0.2
Vertical activity count, locomotor time 1	0.4	0.9	1.1	1.1	-0.9
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.1	-0.0
Bouts of movement, locomotor time 2	0.3	0.5	0.5	-0.7	0.7
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.4	0.3
Rest time, locomotor task time 2	2.6	3.3	3.8	1.9	-1.7
Distance moved, locomotor task time 2	1.5	1.8	2.1	-1.2	1.4
Vertical activity count, locomotor time 2	0.3	0.4	0.8	0.0	0.9
Light reinforcement 1	0.0	0.1	0.1	0.2	-0.4
Light reinforcement 2	0.5	0.7	0.8	0.9	-0.8
Bone: marrow area	1.6	3.4	4.6	1.5	-2.1
Bone: maximum diameter	0.1	0.2	0.2	-0.5	0.4
Bone: maximum force	2.8	5.0	7.1	-2.7	1.7
Bone: maximum moment	2.6	4.5	6.4	-2.5	1.6
Mean time between licks in bursts	0.2	0.4	0.4	-0.6	0.6
Mean num. licks in bursts	0.2	0.4	0.4	0.6	-0.6
Cd content in liver	1.3	1.5	1.6	1.1	-1.3
Co content in liver	0.9	1.0	2.0	1.4	-0.3
Cu content in liver	0.1	0.1	0.1	-0.1	-0.3
Fe content in liver	0.3	0.3	0.4	-0.5	0.7
K content in liver	0.3	0.3	0.5	-0.7	0.3
Mg content in liver	0.5	0.6	0.7	0.6	-0.9
Mn content in liver	3.8	4.2	4.8	-2.2	1.9
Na content in liver	0.7	0.8	1.2	-0.7	1.1
Rb content in liver	2.3	2.7	3.0	1.5	-1.7
Se content in liver	0.1	0.1	0.2	0.2	-0.5
Sr content in liver	3.3	2.8	3.2	-1.6	1.8
Zn content in liver	0.2	0.2	0.3	-0.5	0.3
Bone: minimum diameter	1.3	2.5	3.8	1.1	-1.9
Time in familiar zone, hab. session 1	0.3	0.3	0.5	0.3	-0.7
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.6	-0.0
Total zone transitions, hab. session 1	0.8	1.1	1.2	-1.1	0.9
Total locomotion distance, hab. session 1	0.4	0.5	0.6	0.7	-0.7
Locomotion velocity, hab. session 1	0.0	0.1	0.1	0.2	-0.2
Time in familiar zone, hab. session 2	0.1	0.1	0.1	0.0	0.4
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.2	-0.4
Total zone transitions, hab. session 2	0.7	0.9	1.7	-1.3	-0.1
Total locomotion distance, hab. session 2	0.3	0.4	0.8	0.2	-0.9
Locomotion velocity, hab. session 2	0.5	0.6	1.1	0.4	-1.1
Novel to familiar place preference ratio	0.7	0.8	1.3	-1.1	0.5
Novelty place preference	0.3	0.3	0.5	-0.7	0.1
Time in novel zone, NPP test	0.2	0.2	0.4	-0.6	-0.0
Total zone transitions, NPP test	1.6	2.3	3.4	-1.8	1.1
Total locomotion distance, NPP test	0.0	0.0	0.0	-0.1	-0.2
Locomotion velocity, NPP test	0.0	0.0	0.1	-0.3	-0.0
Intraocular pressure	0.9	1.3	2.1	1.5	-0.6
Delta distance traveled before/after self-admin	0.0	0.1	0.1	0.3	-0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.0	0.1	0.1
Parametrial fat weight	4.7	11.1	11.5	3.4	-3.3
Pavlov. Cond. lever latency	0.2	0.2	0.3	0.6	-0.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.4	-0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.3	0.1
Pavlov. Cond. index score	0.1	0.2	0.2	-0.5	0.4
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.3	0.1
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.3	0.1
Pavlov. Cond. magazine entry number	0.3	0.4	0.4	0.6	-0.6
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	0.4	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.4	-0.6	0.5
Pavlov. Cond. response bias	0.2	0.3	0.3	-0.5	0.6
Pavlov. Cond. lever latency	0.7	0.9	1.1	1.0	-0.8
Pavlov. Cond. magazine entry latency	4.4	5.3	7.2	-2.7	1.8
Pavlov. Cond. change in total contacts	1.3	2.1	3.2	-1.8	1.0
Pavlov. Cond. index score	2.5	3.4	4.7	-2.2	1.4
Pavlov. Cond. latency score	2.3	3.0	4.0	-2.0	1.4
Pavlov. Cond. lever contacts	0.6	0.9	1.1	-1.1	0.8
Pavlov. Cond. magazine entry number	7.1	8.7	11.4	3.4	-2.5
Pavlov. Cond. intertrial magazine entries	1.0	1.6	1.9	1.4	-1.1
Pavlov. Cond. lever-magazine prob. diff.	3.0	4.1	5.5	-2.4	1.6
Pavlov. Cond. response bias	1.9	2.7	3.8	-1.9	1.2
Time in closed arm before self-admin	0.6	0.7	0.8	0.8	-0.9
Time in closed arm after self-admin	0.2	0.2	0.3	0.6	-0.3
Time in open arm before self-admin	0.0	0.0	0.0	0.2	0.1
Time in open arm after self-admin	0.1	0.1	0.1	-0.2	0.2
Bone: periosteal estimation	0.0	0.1	0.1	0.0	-0.3
Bone: periosteal perimeter	0.1	0.1	0.2	-0.4	-0.1
Bone: post-yield work	0.6	0.9	1.0	-0.9	-1.0
Progressive ratio test 1 active lever presses	0.1	0.2	0.3	0.2	-0.6
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.1	-0.5
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	0.1	-0.3
Progressive ratio test 2 active lever presses	2.2	2.5	3.2	1.4	-1.8
Progressive ratio test 2 breakpoint	2.0	2.3	2.9	1.3	-1.7
Progressive ratio test 2 inactive lever presses	6.4	10.5	11.4	3.1	-3.4
Incentive Sensitization - Responses	0.1	0.1	0.3	-0.1	-0.5
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	0.1	-0.7
Sum of active levers in priming session hrs 5-6	3.2	3.0	3.7	-1.5	1.9
Progressive ratio	0.3	0.4	0.8	-0.9	-0.2
Food seeking constrained by brief footshock	0.2	0.3	0.4	-0.4	0.6
Seeking ratio, punishment vs. effort	0.4	0.6	1.2	1.1	-0.1
Retroperitoneal fat weight	10.5	44.8	46.8	6.8	-6.5
Reaction time number correct	0.3	0.6	0.8	-0.6	0.9
Reaction time mean minus median	1.7	4.3	4.4	-2.1	2.0
Reaction time mean minus median AUC	1.1	2.9	3.6	-1.5	1.9
Reaction time num false alarms	0.1	0.1	0.2	0.4	0.0
Reaction time num false alarms AUC	0.2	0.2	0.4	-0.2	0.7
Reaction time trials correct on left	0.3	0.6	0.8	-0.6	0.9
Reaction time trials on left	0.4	0.8	1.1	-0.7	1.1
Reaction time mean	0.0	0.0	0.0	0.1	0.2
Reaction time mean AUC	0.0	0.0	0.0	0.1	0.0
Median of all reaction times	0.2	0.3	0.4	0.6	-0.5
Reaction time omissions	1.9	2.8	3.0	-1.6	1.7
Reaction time false alarm rate	0.1	0.1	0.2	0.4	-0.0
Reaction time premature initiation rate	2.5	3.5	3.6	-1.8	1.9
Reaction time premature initiations	3.6	6.5	7.0	-2.4	2.7
Std. dev. reaction times	0.6	1.0	1.2	-0.9	1.1
Reaction time trials completed	0.4	0.8	1.1	-0.7	1.1
Reaction time trials AUC	0.3	0.5	0.7	-0.5	0.9
Run reversals in cocaine runway, females	0.1	0.1	0.2	-0.4	0.1
Run reversals in cocaine runway, males	0.3	0.3	0.3	0.5	0.6
Latency to leave start box in cocaine runway	0.2	0.2	0.4	0.1	-0.7
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.0	-0.5
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.2	0.0
Std. dev. time between licks in bursts	0.0	0.0	0.1	0.2	0.2
Total sessions with >9 infusions	0.1	0.2	0.3	-0.2	-0.5
Short access day 1 total inactive lever presses	2.3	3.1	3.6	1.6	-1.9
Short access day 10 total inactive lever presses	0.1	0.3	0.4	0.7	-0.5
Short access day 1 total infusions	2.0	2.6	3.8	1.2	-1.9
Short access day 10 total infusions	1.0	1.3	2.5	0.2	-1.6
Short access total infusions	0.7	1.0	1.8	0.3	-1.3
Short access day 1 locomotion	1.3	1.6	2.3	1.0	-1.5
Short access day 10 total locomotion	0.8	1.5	2.1	0.9	-1.4
Short access total locomotion	1.5	1.8	2.6	1.0	-1.6
One hour access (0.3 mA shock)	6.5	7.5	7.8	2.8	-2.7
Compulsive drug intake	2.2	2.7	3.6	-1.3	1.9
One hour access (shock baseline)	5.9	9.0	9.7	2.9	-3.1
Social response proportion	0.4	0.5	0.6	-0.8	0.6
Social responses	0.3	0.4	0.4	-0.6	0.6
Social time	0.4	0.5	0.6	-0.6	0.8
Soleus weight	4.1	12.1	14.8	3.9	-3.1
Bone: stiffness	1.7	2.8	4.6	-2.1	1.0
Tibialis anterior weight	12.4	42.0	43.6	-6.4	6.6
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	-0.3	0.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.5	-0.1
Time to tail flick, test, before self-admin	2.7	2.8	3.5	1.4	-1.9
Time to tail flick, test, after self-admin	0.0	0.0	0.0	-0.0	0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.5	0.1
Delta time to tail flick, test, before/after SA	2.9	3.0	4.5	-1.2	2.1
Tibia length	1.4	3.8	4.1	-1.9	2.0
Ambulatory time before self-admin	0.2	0.3	0.5	-0.7	0.2
Ambulatory time after self-admin	0.4	0.5	0.8	0.5	-0.9
Bone: tissue strength	0.0	0.0	0.0	-0.1	-0.2
Total heroin consumption	5.2	6.1	7.7	-2.8	2.1
Bone: trabecular number	0.5	0.8	1.6	-1.3	-0.1
Bone: trabecular spacing	0.3	0.4	0.7	0.8	-0.4
Bone: trabecular thickness	0.7	0.8	1.4	0.5	-1.2
Bone: trabecular tissue density	3.3	4.9	7.0	2.6	-1.7
Water consumed over 24 hours	0.9	1.3	1.6	-1.3	1.0
Number of responses in last shaping day	0.0	0.0	0.0	0.1	-0.2