Hub : Genes

Alg6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Alg6 0.27 0.15 1.2e-12 0.06 0.07 0.06 0.07 4.2e-07 6.5e-08 5.4e-07 4.0e-08
2 Adipose gene expression Alg6 0.06 0.05 4.9e-04 0.01 0.01 0.01 0.01 8.1e-03 7.3e-03 1.5e-02 7.1e-03
3 Adipose mRNA stability Alg6 0.04 0.03 3.5e-05 0.03 0.02 0.02 0.02 4.9e-04 9.2e-04 2.0e-03 1.1e-03
4 Adipose alternative polyA XM_063287948.1 0.06 0.05 1.3e-06 0.03 0.03 0.02 0.03 3.1e-04 3.1e-04 8.8e-04 6.9e-04
5 Adipose alternative polyA XM_039110268.1 0.07 0.05 7.9e-07 0.03 0.03 0.03 0.03 2.5e-04 2.3e-04 7.9e-04 6.4e-04
6 Adipose alternative polyA XM_039110268.1 0.05 0.03 1.1e-05 0.02 0.02 0.01 0.01 2.8e-03 9.6e-04 1.3e-02 1.2e-02
7 pVTA alternative polyA XM_039110268.1 0.09 0.12 3.4e-03 0.03 0.02 0.02 0.02 2.7e-03 1.3e-02 1.6e-02 6.2e-03
8 Liver alternative polyA XM_039110268.1 0.02 0.02 7.2e-03 0 0.01 0 0 1.1e-01 4.2e-02 2.3e-01 1.5e-01
9 NAcc intron excision ratio chr5_119559299_119605561 0.01 0.01 7.7e-03 0.01 0.01 0 0 4.1e-02 8.1e-03 5.3e-02 4.9e-02
10 Eye gene expression Alg6 0.28 0.17 4.1e-03 0.1 0.05 0.04 0.04 1.2e-02 6.8e-02 7.1e-02 7.7e-02
11 Brain mRNA stability Alg6 0.07 0.05 7.8e-06 0.06 0.06 0.05 0.06 1.4e-06 6.3e-06 8.5e-06 2.4e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.50.81.40.91.2-0.7-0.90.90.9-0.80.9-0.9-0.90.9
Area under the delay curve0.20.30.60.70.8-0.6-0.60.60.6-0.50.5-0.5-0.40.3
BMI with tail0.72.52.9-1.5-1.61.71.6-1.6-1.61.5-1.61.61.5-1.4
BMI without tail0.84.15.0-2.1-1.82.22.0-2.0-2.02.0-2.02.02.0-1.9
Body weight0.31.52.4-1.1-1.51.41.2-1.2-1.21.3-1.21.11.0-1.1
Weight adjusted by age0.51.42.0-0.9-0.61.31.2-1.2-1.21.2-1.21.21.3-1.4
Bone surface1.22.43.0-1.4-1.31.51.5-1.5-1.61.5-1.61.51.7-1.7
Bone volume0.20.30.5-0.5-0.30.60.5-0.5-0.50.6-0.60.50.7-0.7
Breakpoint value in progressive ratio session0.40.71.40.90.0-1.0-0.70.70.8-1.20.7-0.7-1.10.8
Number of licking bursts0.00.10.3-0.3-0.60.00.3-0.3-0.30.1-0.30.3-0.1-0.2
Context. condit. distance diff. score2.93.55.12.31.3-2.0-1.91.91.9-2.01.9-1.9-1.71.8
Locomotion velocity, session 10.30.31.0-0.7-1.00.40.6-0.6-0.60.5-0.50.50.3-0.1
Locomotion distance, session 10.60.71.00.80.5-1.0-0.90.90.9-0.90.9-0.9-0.71.0
Locomotion velocity, session 20.00.00.10.10.30.3-0.10.00.00.40.0-0.00.1-0.1
Locomotion distance, session 20.20.20.5-0.2-0.50.40.4-0.4-0.40.4-0.40.50.7-0.5
Locomotion velocity, session 30.10.10.40.40.3-0.6-0.30.30.3-0.60.3-0.3-0.30.2
Locomotion distance, session 30.00.00.20.2-0.2-0.5-0.00.00.0-0.4-0.00.0-0.0-0.2
Stereotopy head waving bouts, day 30.91.11.71.11.3-1.0-1.11.11.0-1.11.0-1.0-1.00.8
Stereotopy head waving duration, day 31.21.52.01.41.4-0.9-1.31.31.2-1.11.3-1.3-1.21.3
Locomotion velocity, session 71.31.42.21.51.1-1.4-1.21.21.1-1.51.1-1.1-0.90.8
Locomotion distance, session 70.50.70.90.90.8-0.9-0.90.80.8-1.00.8-0.8-0.90.6
Stereotopy head waving bouts, day 70.70.81.1-0.6-1.10.90.9-0.9-0.90.8-0.90.90.9-0.8
Stereotopy head waving duration, day 71.01.31.8-0.9-1.31.11.2-1.2-1.21.1-1.11.11.2-1.0
Locomotion velocity, session 80.20.30.60.8-0.1-0.7-0.40.40.4-0.70.4-0.4-0.60.5
Locomotion distance, session 80.91.31.91.40.8-1.3-1.21.21.2-1.21.2-1.1-1.01.2
Degree of sensitization distance0.00.00.1-0.2-0.10.30.1-0.1-0.10.2-0.10.00.10.0
Degree of sensitization stereotypy1.21.31.9-1.0-1.41.21.2-1.2-1.11.1-1.11.11.2-0.9
Conditioned locomotion0.10.10.20.4-0.4-0.3-0.20.20.2-0.40.2-0.2-0.00.2
Cocaine response after cond. corrected0.40.61.3-0.9-1.10.50.8-0.8-0.70.5-0.70.70.6-0.6
Cocaine response after cond. not corrected0.30.41.2-0.9-1.10.40.7-0.7-0.70.3-0.60.70.3-0.6
Cocaine response before conditioning0.00.00.10.00.2-0.1-0.10.10.1-0.10.1-0.1-0.30.1
Saline control response0.00.10.1-0.3-0.30.30.2-0.2-0.20.4-0.20.20.1-0.1
Bone: connectivity density1.32.12.5-1.6-1.21.61.5-1.5-1.51.5-1.51.51.4-1.5
Bone: cortical apparent density5.38.39.52.63.1-2.9-2.92.92.9-2.72.9-2.9-2.92.8
Bone: cortical area0.30.60.8-0.8-0.50.90.7-0.7-0.70.9-0.70.70.9-0.6
Bone: cortical porosity0.50.50.9-0.8-1.00.80.8-0.8-0.70.8-0.70.70.5-0.5
Bone: cortical porosity0.91.01.7-1.1-1.31.11.0-1.0-1.01.1-1.01.00.5-0.7
Bone: cortical thickness0.10.20.40.30.3-0.2-0.40.40.5-0.20.5-0.5-0.50.6
Bone: cortical thickness0.10.10.20.40.2-0.2-0.40.40.4-0.20.4-0.4-0.40.4
Bone: cortical tissue density5.18.29.12.53.0-2.8-2.92.92.9-2.72.9-2.9-2.92.8
Condit. Reinf. active minus inactive responses0.60.72.0-1.4-0.80.80.8-0.8-0.80.8-0.80.80.7-0.6
Condit. Reinf. active-inactive response ratio0.20.30.8-0.9-0.80.30.5-0.5-0.50.3-0.40.40.3-0.1
Condit. Reinf. active responses1.51.93.7-1.9-1.41.41.4-1.4-1.41.3-1.31.41.2-1.1
Condit. Reinf. inactive responses0.70.91.2-1.1-1.01.01.0-1.0-0.90.9-0.90.91.0-0.8
Incentive salience index mean0.91.12.7-1.7-1.11.11.0-1.0-1.01.1-1.01.00.8-0.6
Condit. Reinf. lever presses0.20.30.8-0.9-0.80.60.5-0.5-0.40.6-0.40.40.10.1
Condit. Reinf. active minus inactive responses0.71.01.70.91.0-0.9-1.01.01.0-0.81.0-1.0-1.31.1
Condit. Reinf. active-inactive response ratio0.10.20.50.30.3-0.3-0.40.40.4-0.30.4-0.4-0.70.7
Condit. Reinf. active responses0.40.61.20.70.7-0.8-0.80.80.8-0.60.8-0.8-1.10.8
Condit. Reinf. inactive responses0.91.41.71.21.2-1.2-1.21.21.2-1.11.2-1.2-1.31.0
Condit. Reinf. lever presses2.02.93.6-1.9-1.51.61.7-1.7-1.71.7-1.71.71.7-1.8
Condit. Reinf. lever reinforcers received0.10.20.40.30.4-0.4-0.40.40.4-0.20.4-0.4-0.70.4
Conditioned reinforcement - actives0.00.10.3-0.6-0.10.10.0-0.0-0.00.20.0-0.00.30.3
Conditioned reinforcement - inactives0.00.10.30.5-0.2-0.3-0.30.30.3-0.30.3-0.4-0.40.4
Conditioned locomotion0.10.10.4-0.4-0.6-0.00.0-0.00.00.00.1-0.00.00.6
Patch foraging indifference point 0 sec4.813.518.3-3.8-4.33.53.7-3.7-3.73.6-3.63.63.5-3.3
Patch foraging indifference point AUC0.81.93.2-1.8-1.21.41.4-1.4-1.41.4-1.31.31.2-1.3
Delay disc. indifference point, 0s delay2.42.74.62.11.4-1.6-1.61.61.6-1.61.6-1.7-1.61.6
Delay disc. indifference point, 16s delay1.31.92.6-1.6-1.31.21.4-1.4-1.41.3-1.41.41.4-1.4
Delay disc. indifference point, 2s delay0.40.51.71.30.8-0.7-0.60.60.6-0.80.5-0.6-0.20.2
Delay disc. indifference point, 24s delay0.00.00.0-0.2-0.0-0.2-0.10.10.1-0.10.1-0.1-0.00.1
Delay disc. indifference point, 4s delay2.22.34.61.82.2-1.3-1.51.51.5-1.31.5-1.5-1.21.2
Delay disc. indifference point, 8s delay0.71.11.71.11.3-1.0-1.11.11.1-0.81.1-1.1-1.00.8
Indifference point function ln k0.30.91.71.31.2-0.9-1.01.01.0-0.80.9-0.9-0.60.9
Indifference point function log k0.30.91.71.31.2-0.9-1.01.01.0-0.80.9-0.9-0.60.9
Patch foraging total patch changes 0 sec4.412.917.5-3.7-4.23.43.6-3.6-3.63.6-3.53.53.5-3.2
Patch foraging total patch changes 12 sec2.02.74.1-1.9-2.01.51.7-1.7-1.71.5-1.61.61.4-1.6
Patch foraging total patch changes 18 sec2.45.68.0-2.5-2.82.42.4-2.4-2.42.5-2.32.32.0-2.0
Patch foraging total patch changes 24 sec0.82.84.7-1.6-2.21.61.7-1.7-1.71.5-1.61.61.4-1.4
Patch foraging total patch changes 6 sec4.57.712.0-3.5-3.22.62.8-2.8-2.82.8-2.62.62.3-2.2
Patch foraging time to switch 0 sec0.51.82.11.31.3-1.5-1.31.31.3-1.41.3-1.3-1.41.4
Patch foraging water rate 0 sec0.62.42.8-1.5-1.41.51.5-1.5-1.51.5-1.51.51.6-1.7
Patch foraging water rate 12 sec1.14.55.6-2.0-2.31.92.1-2.1-2.12.1-2.12.12.4-2.2
Patch foraging water rate 18 sec0.30.61.0-0.8-1.00.70.8-0.8-0.80.6-0.80.80.8-0.5
Patch foraging water rate 24 sec0.00.00.1-0.0-0.10.10.2-0.2-0.10.0-0.10.10.4-0.1
Patch foraging water rate 6 sec0.00.00.20.20.40.1-0.00.00.00.20.0-0.10.3-0.1
Seeking ratio, delayed vs. immediate footshock0.00.00.30.5-0.40.10.1-0.1-0.0-0.1-0.10.1-0.1-0.2
Distance traveled before self-admin0.30.61.3-0.7-1.20.70.8-0.8-0.80.6-0.80.80.2-1.0
Distance traveled after self-admin0.50.91.8-1.0-0.60.91.0-1.0-1.00.8-1.01.00.5-1.4
Extensor digitorum longus weight0.41.62.11.40.4-1.3-1.31.31.3-1.31.3-1.3-1.31.4
Bone: elastic displacement0.50.71.00.70.7-0.8-0.80.80.8-0.60.9-0.9-0.81.0
Bone: elastic work1.31.82.21.31.2-1.2-1.31.31.3-1.11.4-1.4-1.41.5
Bone: endosteal estimation0.61.42.2-1.1-1.01.21.1-1.1-1.21.1-1.21.21.5-1.3
Bone: endosteal perimeter1.23.04.1-1.5-1.41.81.7-1.7-1.71.7-1.81.82.0-1.8
Epididymis fat weight0.00.00.10.2-0.1-0.0-0.20.20.2-0.00.2-0.2-0.00.3
Delta time in closed arm before/after self-admin0.00.00.40.0-0.6-0.10.0-0.0-0.0-0.0-0.00.00.20.1
Delta time in open arm before/after self-admin1.72.13.0-1.7-0.61.71.4-1.4-1.41.7-1.41.41.2-1.6
Diff in mean of infusions in LGA sessions0.10.21.1-0.3-1.10.20.4-0.4-0.30.2-0.30.30.1-0.0
Delay discount exponential model param0.20.30.6-0.7-0.80.60.6-0.6-0.50.5-0.50.50.3-0.2
Extinction: sum of active levers before priming0.50.71.31.10.4-0.9-0.80.80.8-1.00.8-0.8-0.90.6
Active lever presses in extinction session 60.10.10.6-0.4-0.80.30.3-0.3-0.30.0-0.30.3-0.3-0.1
Bone: final force0.30.50.60.70.7-0.7-0.70.70.7-0.70.7-0.7-0.70.6
Bone: final moment0.00.00.00.10.0-0.0-0.10.10.1-0.00.1-0.1-0.10.1
Food consumed during 24 hour testing period0.20.50.80.70.9-0.9-0.70.70.7-0.80.6-0.6-0.60.1
Glucose0.10.20.4-0.6-0.50.60.5-0.5-0.50.4-0.40.40.10.0
Heart weight2.23.64.11.81.3-2.0-1.91.91.9-2.01.9-1.9-2.02.0
Delay discount hyperbolic model param0.30.30.9-0.8-0.90.60.6-0.6-0.60.5-0.50.50.3-0.2
Intermittent access intake day 1-15 change0.00.10.20.10.5-0.4-0.30.30.3-0.50.3-0.3-0.40.3
Intermittent access intake escalation0.10.60.80.60.9-0.9-0.70.70.7-0.90.7-0.7-0.80.6
Intermittent access intake escalation 20.10.20.60.10.3-0.6-0.40.40.4-0.80.4-0.4-0.60.5
Intermitt. access day 1 inactive lever presses0.00.20.40.1-0.60.60.4-0.4-0.40.5-0.40.30.2-0.3
Intermitt. access day 15 inactive lever presses0.31.93.31.81.2-1.2-1.41.41.4-1.31.4-1.4-1.11.4
Intermitt. access escalation Index0.10.43.60.41.9-0.0-0.40.40.3-0.10.3-0.4-0.1-0.1
Intermittent access day 1 total infusions0.20.71.00.70.8-0.6-0.90.90.9-0.60.9-0.9-1.01.0
Intermittent access day 15 total infusions0.51.21.70.81.1-1.1-1.11.11.1-1.01.1-1.1-1.31.2
Intermittent access terminal intake (last 3 days)0.20.30.50.30.5-0.6-0.60.60.6-0.50.6-0.6-0.70.7
Intermittent access total infusions0.91.11.80.80.7-1.0-1.11.11.1-0.91.1-1.1-1.31.3
Intermittent access day 1 locomotion0.00.00.2-0.5-0.20.1-0.00.00.00.10.1-0.0-0.30.3
Intermittent access day 15 total locomotion0.10.31.1-1.1-0.30.60.5-0.5-0.40.7-0.40.40.40.1
Intermittent access total locomotion0.00.00.2-0.3-0.1-0.0-0.10.10.1-0.00.1-0.1-0.40.5
Intermittent access standard deviation0.10.51.00.40.3-0.6-0.70.70.7-0.60.8-0.7-0.91.0
Left kidney weight0.00.20.50.7-0.3-0.7-0.30.30.4-0.70.4-0.4-0.50.5
Right kidney weight0.11.02.01.40.6-1.1-0.90.90.9-1.20.9-0.9-1.00.8
Cocaine induced anxiety0.00.10.60.20.80.2-0.20.20.1-0.10.1-0.10.2-0.3
Post-drug Anxiety0.70.82.51.21.6-0.5-0.90.90.9-0.90.8-0.8-0.60.4
Baseline Anxiety0.30.51.01.00.7-0.8-0.60.70.6-0.70.6-0.6-0.70.6
Tail length0.00.10.20.40.0-0.3-0.40.40.4-0.40.4-0.4-0.40.3
Length with tail0.00.00.30.2-0.50.10.0-0.0-0.00.20.0-0.0-0.1-0.0
Length without tail0.00.20.9-0.2-1.00.50.4-0.4-0.40.6-0.30.30.3-0.3
Times rat made contact with spout0.20.20.9-0.6-0.90.10.4-0.4-0.40.2-0.30.3-0.0-0.3
Lifetime Intake0.81.01.70.80.8-0.8-1.11.11.1-0.81.1-1.1-1.21.3
Liver weight, left2.64.45.32.31.9-2.0-2.12.22.2-1.92.2-2.2-2.22.0
Liver weight, right1.32.33.61.60.6-1.4-1.51.51.5-1.41.6-1.6-1.91.9
Locomotor activity0.10.20.5-0.4-0.60.50.4-0.4-0.40.7-0.30.30.4-0.1
Locomotor testing distance1.22.93.6-1.6-1.91.61.7-1.7-1.71.8-1.71.61.7-1.6
Locomotor testing rearing0.00.20.8-0.5-0.90.30.4-0.4-0.40.4-0.30.3-0.1-0.0
Locomotion in novel chamber1.11.52.3-1.0-1.51.01.3-1.3-1.20.9-1.31.31.2-1.4
Locomotion in novel chamber post-restriction0.10.41.0-0.00.4-0.5-0.60.60.6-0.50.7-0.6-1.01.0
Fecal boli incidents, locomotor time 10.00.00.2-0.4-0.0-0.1-0.00.00.0-0.20.1-0.00.00.4
Change in fecal boli incidents, locomotor task0.20.20.60.80.5-0.0-0.50.50.40.00.4-0.4-0.3-0.1
Time >=10cm from walls, locomotor time 10.20.30.7-0.2-0.10.80.4-0.4-0.40.4-0.50.50.6-0.8
Bouts of movement, locomotor time 10.30.42.2-0.4-1.50.60.7-0.6-0.60.4-0.60.60.2-0.2
Total resting periods, locomotor time 10.40.41.9-0.3-1.40.60.7-0.7-0.60.4-0.60.60.3-0.4
Rest time, locomotor task time 10.20.30.6-0.2-0.20.80.5-0.5-0.50.6-0.50.50.6-0.6
Distance moved, locomotor task time 10.10.20.40.40.6-0.5-0.40.40.4-0.60.4-0.5-0.70.6
Vertical activity count, locomotor time 10.00.10.4-0.00.7-0.0-0.10.10.10.40.0-0.10.2-0.2
Time >=10cm from walls, locomotor time 21.02.84.82.21.3-1.5-1.71.71.7-1.51.7-1.7-1.71.5
Bouts of movement, locomotor time 20.51.62.2-1.3-1.31.51.3-1.3-1.31.5-1.21.20.9-1.2
Total resting periods, locomotor time 20.41.62.1-1.3-1.21.41.3-1.3-1.31.5-1.21.21.0-1.3
Rest time, locomotor task time 20.20.40.7-0.8-0.10.70.5-0.5-0.50.8-0.60.60.7-0.7
Distance moved, locomotor task time 21.92.54.22.01.1-1.6-1.41.41.4-1.71.5-1.5-1.71.6
Vertical activity count, locomotor time 20.40.92.11.50.6-0.9-0.90.90.9-0.70.9-0.9-0.91.1
Light reinforcement 10.00.20.40.40.1-0.5-0.40.40.4-0.50.4-0.5-0.60.6
Light reinforcement 20.20.40.70.80.8-0.6-0.60.60.6-0.70.6-0.6-0.70.6
Bone: marrow area0.51.21.9-1.0-1.01.11.0-1.0-1.11.0-1.11.11.4-1.2
Bone: maximum diameter0.61.21.7-1.2-0.91.21.1-1.1-1.11.2-1.11.11.3-1.1
Bone: maximum force0.00.00.00.1-0.1-0.0-0.00.00.0-0.10.0-0.0-0.10.1
Bone: maximum moment0.20.40.7-0.6-0.80.70.7-0.7-0.70.7-0.60.60.5-0.5
Mean time between licks in bursts1.37.89.63.12.7-2.7-2.92.92.8-2.82.8-2.9-2.62.6
Mean num. licks in bursts0.00.00.1-0.3-0.20.20.1-0.1-0.10.2-0.10.00.3-0.0
Cd content in liver2.22.43.4-1.7-1.81.91.5-1.5-1.51.8-1.41.41.4-1.1
Co content in liver0.10.10.40.4-0.6-0.2-0.00.00.1-0.10.1-0.1-0.10.3
Cu content in liver1.01.21.61.10.6-1.1-1.01.01.1-1.11.1-1.1-1.31.1
Fe content in liver0.00.10.20.4-0.5-0.1-0.10.10.2-0.00.2-0.2-0.00.1
K content in liver2.32.32.71.61.6-1.5-1.51.51.5-1.51.5-1.5-1.51.4
Mg content in liver0.10.10.2-0.3-0.10.30.4-0.4-0.40.3-0.40.40.3-0.4
Mn content in liver0.10.10.3-0.4-0.50.10.3-0.3-0.30.1-0.30.30.0-0.1
Na content in liver3.54.05.42.12.3-1.8-2.12.12.0-1.82.1-2.1-1.91.8
Rb content in liver0.50.60.80.60.5-0.9-0.70.70.8-0.90.8-0.8-0.80.7
Se content in liver0.10.10.3-0.0-0.60.30.3-0.3-0.30.3-0.30.30.4-0.4
Sr content in liver1.41.21.8-1.1-0.31.31.1-1.1-1.11.3-1.11.11.2-1.2
Zn content in liver1.11.31.6-1.3-1.11.21.2-1.2-1.11.3-1.11.11.0-0.8
Bone: minimum diameter1.73.34.3-1.9-1.51.91.8-1.8-1.81.9-1.81.82.1-1.8
Time in familiar zone, hab. session 12.12.43.71.90.9-1.7-1.51.51.5-1.71.5-1.5-1.41.5
Time in novel zone, hab. session 15.46.07.1-2.7-1.92.72.4-2.4-2.42.6-2.42.42.5-2.5
Total zone transitions, hab. session 11.21.72.31.11.0-1.4-1.31.31.3-1.41.3-1.3-1.51.3
Total locomotion distance, hab. session 10.30.40.60.80.7-0.7-0.70.70.6-0.70.6-0.6-0.40.3
Locomotion velocity, hab. session 10.30.40.60.60.7-0.8-0.70.70.6-0.70.6-0.6-0.50.4
Time in familiar zone, hab. session 20.30.30.80.5-0.1-0.7-0.40.40.5-0.70.5-0.5-0.90.6
Time in novel zone, hab. session 20.60.71.2-0.6-0.41.00.7-0.7-0.81.0-0.80.81.1-0.8
Total zone transitions, hab. session 25.77.38.32.82.6-2.9-2.72.72.7-2.82.7-2.7-2.62.5
Total locomotion distance, hab. session 23.64.75.62.42.2-2.3-2.22.22.2-2.22.2-2.2-2.11.9
Locomotion velocity, hab. session 23.24.35.32.32.2-2.2-2.12.12.1-2.12.0-2.0-1.91.7
Novel to familiar place preference ratio0.91.11.6-1.1-1.11.31.0-1.0-1.01.3-1.01.00.9-0.9
Novelty place preference0.50.61.1-0.8-0.81.00.8-0.8-0.81.0-0.70.70.6-0.6
Time in novel zone, NPP test0.70.91.4-0.9-1.01.10.9-0.9-0.91.2-0.90.90.7-0.7
Total zone transitions, NPP test1.72.43.11.41.4-1.6-1.61.61.6-1.51.6-1.6-1.71.7
Total locomotion distance, NPP test0.71.01.51.01.2-0.9-1.01.01.0-0.81.0-1.0-0.90.7
Locomotion velocity, NPP test0.71.01.51.01.2-0.9-1.11.11.0-0.91.0-1.0-0.90.7
Intraocular pressure0.10.11.10.11.00.1-0.30.30.20.10.2-0.2-0.0-0.1
Delta distance traveled before/after self-admin0.40.40.6-0.8-0.10.70.7-0.7-0.70.6-0.70.70.6-0.6
Delta ambulatory time before/after self-admin0.10.20.4-0.70.30.50.4-0.4-0.50.5-0.50.50.6-0.5
Parametrial fat weight6.515.417.1-4.0-3.64.13.9-3.9-3.94.1-3.93.93.7-3.9
Pavlov. Cond. lever latency1.11.43.11.41.8-1.1-1.21.21.2-1.11.1-1.2-0.90.7
Pavlov. Cond. magazine entry latency0.10.10.3-0.2-0.5-0.1-0.00.00.10.00.1-0.1-0.40.5
Pavlov. Cond. change in total contacts1.11.22.0-1.4-1.31.01.1-1.1-1.11.0-1.01.00.8-0.8
Pavlov. Cond. index score0.50.62.2-1.1-1.50.70.8-0.8-0.70.8-0.70.70.4-0.2
Pavlov. Cond. latency score0.60.72.3-1.1-1.50.80.8-0.8-0.80.8-0.70.70.4-0.2
Pavlov. Cond. lever contacts0.60.72.1-1.1-1.40.70.9-0.8-0.80.7-0.80.80.5-0.4
Pavlov. Cond. magazine entry number0.10.20.70.20.40.30.3-0.3-0.30.2-0.40.30.5-0.8
Pavlov. Cond. intertrial magazine entries0.50.62.10.31.4-0.6-0.80.70.7-0.80.7-0.7-0.60.7
Pavlov. Cond. lever-magazine prob. diff.0.70.82.3-1.2-1.50.80.9-0.9-0.80.8-0.80.80.5-0.3
Pavlov. Cond. response bias0.20.21.2-0.8-1.10.30.4-0.4-0.40.3-0.30.30.10.1
Pavlov. Cond. lever latency1.82.63.71.91.5-1.7-1.51.51.5-1.81.5-1.5-1.61.5
Pavlov. Cond. magazine entry latency1.72.32.8-1.7-1.51.51.5-1.5-1.51.4-1.51.61.6-1.5
Pavlov. Cond. change in total contacts1.02.53.4-1.8-1.11.61.5-1.5-1.51.6-1.51.51.8-1.7
Pavlov. Cond. index score1.42.22.8-1.7-1.41.51.4-1.4-1.41.5-1.41.41.6-1.5
Pavlov. Cond. latency score1.21.82.4-1.5-1.31.41.3-1.3-1.31.4-1.31.31.5-1.3
Pavlov. Cond. lever contacts1.92.84.0-2.0-1.41.81.6-1.6-1.61.8-1.61.61.7-1.6
Pavlov. Cond. magazine entry number0.70.91.31.20.8-1.0-0.90.90.9-0.90.9-1.0-1.00.9
Pavlov. Cond. intertrial magazine entries0.92.12.31.41.5-1.4-1.41.41.4-1.31.4-1.4-1.51.5
Pavlov. Cond. lever-magazine prob. diff.1.52.33.0-1.7-1.31.61.5-1.5-1.51.6-1.51.51.6-1.5
Pavlov. Cond. response bias1.82.43.4-1.8-1.41.61.5-1.5-1.51.6-1.51.51.6-1.5
Time in closed arm before self-admin0.10.20.80.10.9-0.5-0.40.40.4-0.60.4-0.3-0.20.3
Time in closed arm after self-admin0.20.20.60.50.1-0.8-0.40.40.5-0.80.4-0.4-0.00.4
Time in open arm before self-admin0.30.31.2-0.1-1.10.60.5-0.5-0.50.7-0.50.50.4-0.3
Time in open arm after self-admin3.53.95.4-2.0-1.52.31.9-1.9-2.02.3-2.01.91.6-2.0
Bone: periosteal estimation0.61.42.1-1.2-1.01.31.1-1.1-1.11.2-1.21.11.5-1.2
Bone: periosteal perimeter0.71.41.6-1.2-0.91.31.2-1.2-1.21.3-1.21.21.3-1.1
Bone: post-yield work1.11.92.4-1.3-1.51.21.4-1.4-1.41.2-1.41.51.4-1.4
Progressive ratio test 1 active lever presses1.62.93.81.31.6-1.5-1.81.81.8-1.41.8-1.8-1.91.9
Progressive ratio test 1 breakpoint2.03.54.41.51.7-1.7-1.91.91.9-1.62.0-1.9-2.12.1
Progressive ratio test 1 inactive lever presses1.12.93.21.61.8-1.5-1.81.81.8-1.51.8-1.8-1.81.7
Progressive ratio test 2 active lever presses0.10.10.3-0.30.3-0.2-0.30.30.3-0.10.4-0.3-0.50.6
Progressive ratio test 2 breakpoint0.20.30.5-0.10.5-0.4-0.50.50.5-0.30.6-0.5-0.70.7
Progressive ratio test 2 inactive lever presses0.00.10.2-0.20.3-0.1-0.20.20.2-0.00.3-0.3-0.30.5
Incentive Sensitization - Responses0.10.20.7-0.8-0.10.50.4-0.4-0.40.5-0.40.40.4-0.1
Incentive Sensitization - Breakpoint0.10.31.0-1.0-0.20.60.6-0.6-0.60.6-0.50.60.6-0.3
Sum of active levers in priming session hrs 5-60.70.72.21.50.3-0.8-0.80.80.8-0.90.7-0.8-0.80.5
Progressive ratio0.10.30.30.40.3-0.6-0.60.60.6-0.50.6-0.5-0.60.6
Food seeking constrained by brief footshock4.45.46.42.22.2-2.0-2.52.52.5-1.72.5-2.5-2.52.5
Seeking ratio, punishment vs. effort0.51.01.31.01.0-0.8-1.01.01.0-0.81.0-1.1-1.21.1
Retroperitoneal fat weight0.52.03.0-1.7-1.51.51.4-1.4-1.31.5-1.31.41.4-1.2
Reaction time number correct0.00.10.9-0.11.00.1-0.10.10.00.1-0.00.00.5-0.4
Reaction time mean minus median0.21.41.8-1.3-1.31.31.2-1.2-1.21.4-1.11.21.0-0.9
Reaction time mean minus median AUC0.10.30.6-0.5-0.60.70.6-0.6-0.60.8-0.50.60.6-0.4
Reaction time num false alarms0.20.30.5-0.7-0.20.60.5-0.5-0.60.5-0.50.50.6-0.5
Reaction time num false alarms AUC0.51.21.9-1.4-0.71.11.1-1.1-1.10.9-1.11.11.1-1.0
Reaction time trials correct on left0.00.10.9-0.11.00.1-0.10.10.00.1-0.00.00.5-0.4
Reaction time trials on left0.00.10.8-0.10.90.10.0-0.0-0.00.1-0.10.10.5-0.4
Reaction time mean0.61.21.5-1.2-1.11.01.1-1.1-1.11.2-1.11.11.2-1.0
Reaction time mean AUC0.20.60.8-0.8-0.80.70.7-0.7-0.70.9-0.70.80.9-0.7
Median of all reaction times0.60.91.5-1.0-0.80.80.9-0.9-0.91.0-1.01.01.2-1.0
Reaction time omissions1.01.72.5-1.6-1.61.31.3-1.3-1.31.3-1.21.20.9-0.9
Reaction time false alarm rate1.01.41.8-1.3-1.21.21.2-1.2-1.21.0-1.21.21.1-1.0
Reaction time premature initiation rate0.20.20.50.50.1-0.7-0.40.40.4-0.60.4-0.5-0.70.3
Reaction time premature initiations0.20.50.70.70.8-0.9-0.70.70.7-0.80.6-0.7-0.70.3
Std. dev. reaction times1.13.74.5-2.0-2.11.91.9-1.9-1.92.1-1.91.91.8-1.7
Reaction time trials completed0.00.10.8-0.10.90.10.0-0.0-0.00.1-0.10.10.5-0.4
Reaction time trials AUC0.00.10.7-0.20.90.10.0-0.0-0.10.2-0.10.10.5-0.4
Run reversals in cocaine runway, females0.00.00.20.4-0.4-0.10.0-0.00.0-0.10.0-0.1-0.10.2
Run reversals in cocaine runway, males0.80.81.1-0.7-1.10.90.9-0.9-0.90.9-0.90.91.0-0.9
Latency to leave start box in cocaine runway0.30.40.70.60.8-0.5-0.70.70.7-0.60.7-0.6-0.40.4
Latency to leave start box in cocaine runway, F0.10.10.2-0.4-0.00.40.2-0.2-0.20.3-0.20.20.4-0.4
Latency to leave start box in cocaine runway, M1.21.11.91.40.9-1.1-1.11.11.1-1.21.0-1.0-0.90.9
Std. dev. time between licks in bursts0.00.00.10.30.2-0.2-0.20.20.1-0.10.1-0.1-0.4-0.2
Total sessions with >9 infusions0.91.11.80.80.7-0.8-1.11.11.1-0.71.1-1.1-1.21.3
Short access day 1 total inactive lever presses0.10.10.50.3-0.2-0.1-0.30.30.3-0.10.3-0.3-0.70.6
Short access day 10 total inactive lever presses0.31.72.2-0.7-1.51.41.4-1.4-1.41.2-1.41.31.3-1.4
Short access day 1 total infusions0.20.40.60.60.8-0.3-0.70.70.7-0.20.7-0.7-0.70.7
Short access day 10 total infusions0.71.12.00.80.1-1.1-1.01.01.0-1.01.1-1.0-1.41.3
Short access total infusions0.30.50.90.40.4-0.5-0.70.70.7-0.40.8-0.8-0.90.9
Short access day 1 locomotion0.00.00.1-0.1-0.20.3-0.10.10.10.40.1-0.10.10.3
Short access day 10 total locomotion0.10.52.4-0.9-1.60.50.7-0.7-0.60.5-0.60.6-0.0-0.2
Short access total locomotion0.10.20.60.1-0.2-0.3-0.40.40.5-0.20.5-0.4-0.80.7
One hour access (0.3 mA shock)0.10.11.0-1.0-0.30.10.2-0.2-0.20.0-0.20.2-0.00.1
Compulsive drug intake2.33.44.4-1.7-1.31.91.9-1.9-1.91.8-1.91.91.8-2.1
One hour access (shock baseline)0.61.62.50.61.0-1.3-1.31.31.4-1.31.4-1.3-1.41.6
Social response proportion0.20.30.9-1.0-0.10.50.4-0.4-0.50.4-0.50.50.4-0.5
Social responses0.30.31.0-0.2-0.1-0.6-0.40.40.5-0.50.5-0.5-1.00.9
Social time0.10.10.4-0.5-0.60.30.2-0.2-0.20.3-0.10.1-0.10.5
Soleus weight0.10.20.30.40.3-0.6-0.30.30.4-0.40.3-0.3-0.60.3
Bone: stiffness0.00.00.00.2-0.00.0-0.10.10.0-0.10.0-0.0-0.1-0.0
Tibialis anterior weight8.428.830.3-5.3-5.55.35.4-5.4-5.45.3-5.45.45.3-5.2
Time to tail flick, vehicle, before self-admin1.92.42.9-1.6-1.71.61.6-1.6-1.61.3-1.61.61.6-1.2
Time to tail flick, vehicle, after self-admin0.61.22.0-1.4-0.51.21.0-1.0-1.01.4-1.01.11.1-1.3
Time to tail flick, test, before self-admin0.00.00.10.20.20.0-0.10.10.1-0.20.1-0.1-0.2-0.1
Time to tail flick, test, after self-admin0.20.20.60.30.8-0.1-0.60.60.5-0.30.5-0.6-0.50.3
Delta time to tail flick, vehicle, before/after SA0.80.92.40.91.5-0.8-1.01.00.9-0.60.9-0.9-0.90.4
Delta time to tail flick, test, before/after SA0.20.30.6-0.8-0.10.80.5-0.5-0.50.7-0.50.50.6-0.5
Tibia length2.98.212.33.52.4-2.9-2.92.92.9-2.92.9-2.9-2.62.6
Ambulatory time before self-admin0.10.20.8-0.1-0.90.30.4-0.4-0.30.3-0.40.4-0.2-0.6
Ambulatory time after self-admin0.61.01.6-1.2-0.70.81.0-1.0-1.00.8-1.01.00.7-1.3
Bone: tissue strength0.30.30.7-0.9-0.50.50.6-0.6-0.60.5-0.60.60.1-0.4
Total heroin consumption0.91.11.81.00.8-1.1-1.01.01.0-1.21.0-1.0-1.40.9
Bone: trabecular number0.10.20.30.40.6-0.3-0.50.40.4-0.40.5-0.5-0.50.5
Bone: trabecular spacing0.00.00.0-0.1-0.0-0.1-0.00.00.1-0.20.0-0.0-0.10.0
Bone: trabecular thickness0.20.30.50.60.7-0.3-0.60.60.6-0.40.6-0.6-0.50.5
Bone: trabecular tissue density12.021.021.84.74.7-4.5-4.64.64.6-4.44.7-4.6-4.64.5
Water consumed over 24 hours0.00.10.6-0.2-0.8-0.20.2-0.2-0.2-0.1-0.20.2-0.1-0.3
Number of responses in last shaping day0.10.21.30.1-1.20.30.2-0.2-0.10.4-0.10.10.10.2