Hub : Genes

Alg6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Alg6 0.27 0.15 1.2e-12 0.06 0.07 0.06 0.07 4.2e-07 6.5e-08 5.4e-07 4.2e-08
2 Adipose gene expression Alg6 0.06 0.05 4.9e-04 0.01 0.01 0.01 0.01 8.1e-03 7.3e-03 1.5e-02 7.3e-03
3 Adipose mRNA stability Alg6 0.04 0.03 3.5e-05 0.03 0.02 0.02 0.02 4.9e-04 9.2e-04 2.0e-03 1.2e-03
4 Adipose alternative polyA XM_063287948.1 0.06 0.05 1.3e-06 0.03 0.03 0.02 0.03 3.1e-04 3.1e-04 8.8e-04 7.3e-04
5 Adipose alternative polyA XM_039110268.1 0.07 0.05 7.9e-07 0.03 0.03 0.03 0.03 2.5e-04 2.3e-04 7.9e-04 7.1e-04
6 Adipose alternative polyA XM_039110268.1 0.05 0.03 1.1e-05 0.02 0.02 0.01 0.01 2.8e-03 9.6e-04 1.3e-02 1.2e-02
7 pVTA alternative polyA XM_039110268.1 0.09 0.12 3.4e-03 0.03 0.02 0.02 0.02 2.7e-03 1.3e-02 1.6e-02 6.5e-03
8 Liver alternative polyA XM_039110268.1 0.02 0.02 7.2e-03 0 0.01 0 0 1.1e-01 4.2e-02 2.3e-01 1.5e-01
9 NAcc intron excision ratio chr5_119559299_119605561 0.01 0.01 7.7e-03 0.01 0.01 0 0 4.1e-02 8.1e-03 5.3e-02 5.0e-02
10 Eye gene expression Alg6 0.28 0.17 4.1e-03 0.1 0.05 0.04 0.04 1.2e-02 6.8e-02 7.1e-02 7.3e-02
11 Brain mRNA stability Alg6 0.07 0.05 7.8e-06 0.06 0.06 0.05 0.06 1.4e-06 6.3e-06 8.5e-06 2.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.50.81.00.91.00.7-0.90.90.90.80.9-0.90.9-0.9
Area under the delay curve0.20.30.50.70.60.6-0.60.60.60.50.5-0.50.4-0.3
BMI with tail0.72.53.2-1.5-1.8-1.71.6-1.6-1.6-1.5-1.61.6-1.51.4
BMI without tail1.44.15.0-2.1-2.1-2.22.0-2.0-2.0-2.0-2.02.0-2.01.9
Body weight0.31.52.1-1.1-1.4-1.41.2-1.2-1.2-1.3-1.21.1-1.01.1
Weight adjusted by age1.01.42.0-0.9-1.0-1.31.2-1.2-1.2-1.2-1.21.2-1.31.4
Bone surface1.32.43.0-1.4-1.5-1.51.5-1.5-1.6-1.5-1.61.5-1.71.7
Bone volume0.20.30.5-0.5-0.5-0.60.5-0.5-0.5-0.6-0.60.5-0.70.7
Breakpoint value in progressive ratio session0.60.71.40.90.51.0-0.70.70.81.20.7-0.71.1-0.8
Number of licking bursts0.00.10.1-0.3-0.4-0.00.3-0.3-0.3-0.1-0.30.30.10.2
Context. condit. distance diff. score2.93.55.12.31.62.0-1.91.91.92.01.9-1.91.7-1.8
Locomotion velocity, session 10.30.30.5-0.7-0.7-0.40.6-0.6-0.6-0.5-0.50.5-0.30.1
Locomotion distance, session 10.60.81.00.80.81.0-0.90.90.90.90.9-0.90.7-1.0
Locomotion velocity, session 20.00.00.10.10.2-0.3-0.10.00.0-0.40.0-0.0-0.10.1
Locomotion distance, session 20.10.20.5-0.2-0.4-0.40.4-0.4-0.4-0.4-0.40.5-0.70.5
Locomotion velocity, session 30.10.10.40.40.30.6-0.30.30.30.60.3-0.30.3-0.2
Locomotion distance, session 30.00.00.20.2-0.10.5-0.00.00.00.4-0.00.00.00.2
Stereotopy head waving bouts, day 30.91.11.31.11.11.0-1.11.11.01.11.0-1.01.0-0.8
Stereotopy head waving duration, day 31.31.52.01.41.40.9-1.31.31.21.11.3-1.31.2-1.3
Locomotion velocity, session 71.31.42.21.51.21.4-1.21.21.11.51.1-1.10.9-0.8
Locomotion distance, session 70.60.70.90.90.80.9-0.90.80.81.00.8-0.80.9-0.6
Stereotopy head waving bouts, day 70.60.70.9-0.6-0.9-0.90.9-0.9-0.9-0.8-0.90.9-0.90.8
Stereotopy head waving duration, day 71.01.21.5-0.9-1.1-1.11.2-1.2-1.2-1.1-1.11.1-1.21.0
Locomotion velocity, session 80.20.30.60.80.30.7-0.40.40.40.70.4-0.40.6-0.5
Locomotion distance, session 80.91.41.91.41.11.3-1.21.21.21.21.2-1.11.0-1.2
Degree of sensitization distance0.00.00.1-0.2-0.1-0.30.1-0.1-0.1-0.2-0.10.0-0.1-0.0
Degree of sensitization stereotypy1.11.21.5-1.0-1.1-1.21.2-1.2-1.1-1.1-1.11.1-1.20.9
Conditioned locomotion0.00.10.10.40.10.3-0.20.20.20.40.2-0.20.0-0.2
Cocaine response after cond. corrected0.40.50.9-0.9-0.8-0.50.8-0.8-0.7-0.5-0.70.7-0.60.6
Cocaine response after cond. not corrected0.30.40.7-0.9-0.7-0.40.7-0.7-0.7-0.3-0.60.7-0.30.6
Cocaine response before conditioning0.00.00.10.00.10.1-0.10.10.10.10.1-0.10.3-0.1
Saline control response0.00.00.1-0.3-0.1-0.30.2-0.2-0.2-0.4-0.20.2-0.10.1
Bone: connectivity density1.42.22.5-1.6-1.4-1.61.5-1.5-1.5-1.5-1.51.5-1.41.5
Bone: cortical apparent density6.08.39.12.63.02.9-2.92.92.92.72.9-2.92.9-2.8
Bone: cortical area0.40.60.8-0.8-0.6-0.90.7-0.7-0.7-0.9-0.70.7-0.90.6
Bone: cortical porosity0.50.50.7-0.8-0.8-0.80.8-0.8-0.7-0.8-0.70.7-0.50.5
Bone: cortical porosity0.91.01.3-1.1-1.1-1.11.0-1.0-1.0-1.1-1.01.0-0.50.7
Bone: cortical thickness0.10.20.40.30.40.2-0.40.40.50.20.5-0.50.5-0.6
Bone: cortical thickness0.10.10.20.40.30.2-0.40.40.40.20.4-0.40.4-0.4
Bone: cortical tissue density6.08.18.92.53.02.8-2.92.92.92.72.9-2.92.9-2.8
Condit. Reinf. active minus inactive responses0.70.72.0-1.4-0.8-0.80.8-0.8-0.8-0.8-0.80.8-0.70.6
Condit. Reinf. active-inactive response ratio0.20.20.8-0.9-0.5-0.30.5-0.5-0.5-0.3-0.40.4-0.30.1
Condit. Reinf. active responses1.51.93.7-1.9-1.3-1.41.4-1.4-1.4-1.3-1.31.4-1.21.1
Condit. Reinf. inactive responses0.70.91.2-1.1-0.9-1.01.0-1.0-0.9-0.9-0.90.9-1.00.8
Incentive salience index mean0.91.12.7-1.7-1.0-1.11.0-1.0-1.0-1.1-1.01.0-0.80.6
Condit. Reinf. lever presses0.20.30.8-0.9-0.5-0.60.5-0.5-0.4-0.6-0.40.4-0.1-0.1
Condit. Reinf. active minus inactive responses0.81.01.70.91.00.9-1.01.01.00.81.0-1.01.3-1.1
Condit. Reinf. active-inactive response ratio0.20.20.50.30.40.3-0.40.40.40.30.4-0.40.7-0.7
Condit. Reinf. active responses0.40.61.20.70.70.8-0.80.80.80.60.8-0.81.1-0.8
Condit. Reinf. inactive responses1.11.41.71.21.21.2-1.21.21.21.11.2-1.21.3-1.0
Condit. Reinf. lever presses2.12.93.6-1.9-1.6-1.61.7-1.7-1.7-1.7-1.71.7-1.71.8
Condit. Reinf. lever reinforcers received0.10.20.40.30.40.4-0.40.40.40.20.4-0.40.7-0.4
Conditioned reinforcement - actives0.00.00.3-0.60.0-0.10.0-0.0-0.0-0.20.0-0.0-0.3-0.3
Conditioned reinforcement - inactives0.10.10.30.50.10.3-0.30.30.30.30.3-0.40.4-0.4
Conditioned locomotion0.00.00.4-0.4-0.10.00.0-0.00.0-0.00.1-0.0-0.0-0.6
Patch foraging indifference point 0 sec7.113.214.8-3.7-3.8-3.53.7-3.7-3.7-3.6-3.63.6-3.53.3
Patch foraging indifference point AUC1.31.93.2-1.8-1.2-1.41.4-1.4-1.4-1.4-1.31.3-1.21.3
Delay disc. indifference point, 0s delay2.52.84.62.11.51.6-1.61.61.61.61.6-1.71.6-1.6
Delay disc. indifference point, 16s delay1.71.92.6-1.6-1.4-1.21.4-1.4-1.4-1.3-1.41.4-1.41.4
Delay disc. indifference point, 2s delay0.40.41.71.30.50.7-0.60.60.60.80.5-0.60.2-0.2
Delay disc. indifference point, 24s delay0.00.00.0-0.20.10.2-0.10.10.10.10.1-0.10.0-0.1
Delay disc. indifference point, 4s delay2.02.13.41.81.61.3-1.51.51.51.31.5-1.51.2-1.2
Delay disc. indifference point, 8s delay0.91.11.31.11.11.0-1.11.11.10.81.1-1.11.0-0.8
Indifference point function ln k0.50.91.71.30.90.9-1.01.01.00.80.9-0.90.6-0.9
Indifference point function log k0.50.91.71.30.90.9-1.01.01.00.80.9-0.90.6-0.9
Patch foraging total patch changes 0 sec6.712.614.1-3.7-3.8-3.43.6-3.6-3.6-3.6-3.53.5-3.53.2
Patch foraging total patch changes 12 sec2.02.63.6-1.9-1.7-1.51.7-1.7-1.7-1.5-1.61.6-1.41.6
Patch foraging total patch changes 18 sec3.65.56.5-2.5-2.5-2.42.4-2.4-2.4-2.5-2.32.3-2.02.0
Patch foraging total patch changes 24 sec1.52.63.4-1.6-1.9-1.61.7-1.7-1.7-1.5-1.61.6-1.41.4
Patch foraging total patch changes 6 sec4.97.411.9-3.5-2.8-2.62.8-2.8-2.8-2.8-2.62.6-2.32.2
Patch foraging time to switch 0 sec0.91.92.11.31.41.5-1.31.31.31.41.3-1.31.4-1.4
Patch foraging water rate 0 sec1.12.42.8-1.5-1.5-1.51.5-1.5-1.5-1.5-1.51.5-1.61.7
Patch foraging water rate 12 sec2.24.65.6-2.0-2.3-1.92.1-2.1-2.1-2.1-2.12.1-2.42.2
Patch foraging water rate 18 sec0.40.61.0-0.8-1.0-0.70.8-0.8-0.8-0.6-0.80.8-0.80.5
Patch foraging water rate 24 sec0.00.00.1-0.0-0.3-0.10.2-0.2-0.1-0.0-0.10.1-0.40.1
Patch foraging water rate 6 sec0.00.00.10.20.0-0.1-0.00.00.0-0.20.0-0.1-0.30.1
Seeking ratio, delayed vs. immediate footshock0.00.00.30.5-0.4-0.10.1-0.1-0.00.1-0.10.10.10.2
Distance traveled before self-admin0.40.61.0-0.7-0.9-0.70.8-0.8-0.8-0.6-0.80.8-0.21.0
Distance traveled after self-admin0.80.91.8-1.0-0.9-0.91.0-1.0-1.0-0.8-1.01.0-0.51.4
Extensor digitorum longus weight0.41.72.11.41.01.3-1.31.31.31.31.3-1.31.3-1.4
Bone: elastic displacement0.60.71.00.70.70.8-0.80.80.80.60.9-0.90.8-1.0
Bone: elastic work1.41.82.21.31.31.2-1.31.31.31.11.4-1.41.4-1.5
Bone: endosteal estimation0.71.42.2-1.1-1.2-1.21.1-1.1-1.2-1.1-1.21.2-1.51.3
Bone: endosteal perimeter1.43.04.1-1.5-1.6-1.81.7-1.7-1.7-1.7-1.81.8-2.01.8
Epididymis fat weight0.00.00.10.20.10.0-0.20.20.20.00.2-0.20.0-0.3
Delta time in closed arm before/after self-admin0.00.00.00.0-0.20.10.0-0.0-0.00.0-0.00.0-0.2-0.1
Delta time in open arm before/after self-admin2.22.13.0-1.7-1.2-1.71.4-1.4-1.4-1.7-1.41.4-1.21.6
Diff in mean of infusions in LGA sessions0.10.10.2-0.3-0.5-0.20.4-0.4-0.3-0.2-0.30.3-0.10.0
Delay discount exponential model param0.20.30.5-0.7-0.6-0.60.6-0.6-0.5-0.5-0.50.5-0.30.2
Extinction: sum of active levers before priming0.70.71.31.10.60.9-0.80.80.81.00.8-0.80.9-0.6
Active lever presses in extinction session 60.10.10.3-0.4-0.6-0.30.3-0.3-0.3-0.0-0.30.30.30.1
Bone: final force0.30.50.60.70.70.7-0.70.70.70.70.7-0.70.7-0.6
Bone: final moment0.00.00.00.10.10.0-0.10.10.10.00.1-0.10.1-0.1
Food consumed during 24 hour testing period0.30.50.80.70.80.9-0.70.70.70.80.6-0.60.6-0.1
Glucose0.10.20.4-0.6-0.5-0.60.5-0.5-0.5-0.4-0.40.4-0.1-0.0
Heart weight2.43.74.11.81.72.0-1.91.91.92.01.9-1.92.0-2.0
Delay discount hyperbolic model param0.30.30.7-0.8-0.6-0.60.6-0.6-0.6-0.5-0.50.5-0.30.2
Intermittent access intake day 1-15 change0.10.10.20.10.50.4-0.30.30.30.50.3-0.30.4-0.3
Intermittent access intake escalation0.30.60.80.60.90.9-0.70.70.70.90.7-0.70.8-0.6
Intermittent access intake escalation 20.20.20.60.10.50.6-0.40.40.40.80.4-0.40.6-0.5
Intermitt. access day 1 inactive lever presses0.00.20.40.1-0.6-0.60.4-0.4-0.4-0.5-0.40.3-0.20.3
Intermitt. access day 15 inactive lever presses0.91.93.31.81.31.2-1.41.41.41.31.4-1.41.1-1.4
Intermitt. access escalation Index0.10.10.60.40.80.0-0.40.40.30.10.3-0.40.10.1
Intermittent access day 1 total infusions0.40.71.00.70.90.6-0.90.90.90.60.9-0.91.0-1.0
Intermittent access day 15 total infusions0.81.31.70.81.31.1-1.11.11.11.01.1-1.11.3-1.2
Intermittent access terminal intake (last 3 days)0.30.40.50.30.70.6-0.60.60.60.50.6-0.60.7-0.7
Intermittent access total infusions1.01.21.80.81.11.0-1.11.11.10.91.1-1.11.3-1.3
Intermittent access day 1 locomotion0.00.00.2-0.50.1-0.1-0.00.00.0-0.10.1-0.00.3-0.3
Intermittent access day 15 total locomotion0.20.31.1-1.1-0.3-0.60.5-0.5-0.4-0.7-0.40.4-0.4-0.1
Intermittent access total locomotion0.00.00.2-0.30.10.0-0.10.10.10.00.1-0.10.4-0.5
Intermittent access standard deviation0.30.51.00.40.70.6-0.70.70.70.60.8-0.70.9-1.0
Left kidney weight0.10.20.50.70.20.7-0.30.30.40.70.4-0.40.5-0.5
Right kidney weight0.21.02.01.40.71.1-0.90.90.91.20.9-0.91.0-0.8
Cocaine induced anxiety0.00.10.30.10.6-0.2-0.20.20.10.10.1-0.1-0.20.3
Post-drug Anxiety0.70.71.51.11.20.5-0.90.90.90.90.8-0.80.6-0.4
Baseline Anxiety0.40.51.01.00.50.8-0.60.70.60.70.6-0.60.7-0.6
Tail length0.00.10.20.40.40.3-0.40.40.40.40.4-0.40.4-0.3
Length with tail0.00.00.00.2-0.1-0.10.0-0.0-0.0-0.20.0-0.00.10.0
Length without tail0.10.20.4-0.2-0.6-0.50.4-0.4-0.4-0.6-0.30.3-0.30.3
Times rat made contact with spout0.10.10.4-0.6-0.5-0.10.4-0.4-0.4-0.2-0.30.30.00.3
Lifetime Intake0.91.11.70.81.10.8-1.11.11.10.81.1-1.11.2-1.3
Liver weight, left2.74.55.42.32.02.0-2.12.22.21.92.2-2.22.2-2.0
Liver weight, right1.42.43.61.61.21.4-1.51.51.51.41.6-1.61.9-1.9
Locomotor activity0.10.20.5-0.4-0.4-0.50.4-0.4-0.4-0.7-0.30.3-0.40.1
Locomotor testing distance1.62.83.3-1.6-1.7-1.61.7-1.7-1.7-1.8-1.71.6-1.71.6
Locomotor testing rearing0.10.10.2-0.5-0.4-0.30.4-0.4-0.4-0.4-0.30.30.10.0
Locomotion in novel chamber1.21.51.9-1.0-1.4-1.01.3-1.3-1.2-0.9-1.31.3-1.21.4
Locomotion in novel chamber post-restriction0.30.41.0-0.00.70.5-0.60.60.60.50.7-0.61.0-1.0
Fecal boli incidents, locomotor time 10.00.00.2-0.40.10.1-0.00.00.00.20.1-0.0-0.0-0.4
Change in fecal boli incidents, locomotor task0.20.20.60.80.40.0-0.50.50.4-0.00.4-0.40.30.1
Time >=10cm from walls, locomotor time 10.30.30.7-0.2-0.4-0.80.4-0.4-0.4-0.4-0.50.5-0.60.8
Bouts of movement, locomotor time 10.30.30.9-0.4-1.0-0.60.7-0.6-0.6-0.4-0.60.6-0.20.2
Total resting periods, locomotor time 10.30.30.9-0.3-1.0-0.60.7-0.7-0.6-0.4-0.60.6-0.30.4
Rest time, locomotor task time 10.20.30.6-0.2-0.6-0.80.5-0.5-0.5-0.6-0.50.5-0.60.6
Distance moved, locomotor task time 10.20.20.40.40.50.5-0.40.40.40.60.4-0.50.7-0.6
Vertical activity count, locomotor time 10.00.00.2-0.00.20.0-0.10.10.1-0.40.0-0.1-0.20.2
Time >=10cm from walls, locomotor time 21.92.84.82.21.51.5-1.71.71.71.51.7-1.71.7-1.5
Bouts of movement, locomotor time 21.01.62.2-1.3-1.4-1.51.3-1.3-1.3-1.5-1.21.2-0.91.2
Total resting periods, locomotor time 20.91.62.1-1.3-1.3-1.41.3-1.3-1.3-1.5-1.21.2-1.01.3
Rest time, locomotor task time 20.30.40.7-0.8-0.5-0.70.5-0.5-0.5-0.8-0.60.6-0.70.7
Distance moved, locomotor task time 22.12.54.22.01.41.6-1.41.41.41.71.5-1.51.7-1.6
Vertical activity count, locomotor time 20.70.92.11.40.80.9-0.90.90.90.70.9-0.90.9-1.1
Light reinforcement 10.10.20.40.40.30.5-0.40.40.40.50.4-0.50.6-0.6
Light reinforcement 20.30.40.70.80.50.6-0.60.60.60.70.6-0.60.7-0.6
Bone: marrow area0.61.21.9-1.0-1.1-1.11.0-1.0-1.1-1.0-1.11.1-1.41.2
Bone: maximum diameter0.71.21.7-1.2-0.9-1.21.1-1.1-1.1-1.2-1.11.1-1.31.1
Bone: maximum force0.00.00.00.10.00.0-0.00.00.00.10.0-0.00.1-0.1
Bone: maximum moment0.20.40.5-0.6-0.7-0.70.7-0.7-0.7-0.7-0.60.6-0.50.5
Mean time between licks in bursts3.27.99.63.12.82.7-2.92.92.82.82.8-2.92.6-2.6
Mean num. licks in bursts0.00.00.1-0.3-0.1-0.20.1-0.1-0.1-0.2-0.10.0-0.30.0
Cd content in liver2.12.33.4-1.7-1.5-1.91.5-1.5-1.5-1.8-1.41.4-1.41.1
Co content in liver0.00.00.20.5-0.30.2-0.00.00.10.10.1-0.10.1-0.3
Cu content in liver1.01.21.61.11.01.1-1.01.01.11.11.1-1.11.3-1.1
Fe content in liver0.00.00.20.4-0.30.1-0.10.10.20.00.2-0.20.0-0.1
K content in liver2.32.22.51.61.41.5-1.51.51.51.51.5-1.51.5-1.4
Mg content in liver0.10.10.2-0.3-0.2-0.30.4-0.4-0.4-0.3-0.40.4-0.30.4
Mn content in liver0.10.10.2-0.4-0.3-0.10.3-0.3-0.3-0.1-0.30.3-0.00.1
Na content in liver3.63.94.52.12.01.8-2.12.12.01.82.1-2.11.9-1.8
Rb content in liver0.50.60.80.60.70.9-0.70.70.80.90.8-0.80.8-0.7
Se content in liver0.10.10.3-0.0-0.5-0.30.3-0.3-0.3-0.3-0.30.3-0.40.4
Sr content in liver1.51.31.8-1.1-1.0-1.31.1-1.1-1.1-1.3-1.11.1-1.21.2
Zn content in liver1.11.31.6-1.3-1.0-1.21.2-1.2-1.1-1.3-1.11.1-1.00.8
Bone: minimum diameter1.93.44.3-1.9-1.7-1.91.8-1.8-1.8-1.9-1.81.8-2.11.8
Time in familiar zone, hab. session 12.52.43.71.91.31.7-1.51.51.51.71.5-1.51.4-1.5
Time in novel zone, hab. session 16.26.27.1-2.7-2.3-2.72.4-2.4-2.4-2.6-2.42.4-2.52.5
Total zone transitions, hab. session 11.31.82.31.11.31.4-1.31.31.31.41.3-1.31.5-1.3
Total locomotion distance, hab. session 10.30.40.60.80.60.7-0.70.70.60.70.6-0.60.4-0.3
Locomotion velocity, hab. session 10.30.40.60.60.60.8-0.70.70.60.70.6-0.60.5-0.4
Time in familiar zone, hab. session 20.30.30.80.50.30.7-0.40.40.50.70.5-0.50.9-0.6
Time in novel zone, hab. session 20.70.71.2-0.7-0.6-1.00.7-0.7-0.8-1.0-0.80.8-1.10.8
Total zone transitions, hab. session 25.87.48.32.82.82.9-2.72.72.72.82.7-2.72.6-2.5
Total locomotion distance, hab. session 23.74.85.62.42.32.3-2.22.22.22.22.2-2.22.1-1.9
Locomotion velocity, hab. session 23.24.35.32.32.22.2-2.12.12.12.12.0-2.01.9-1.7
Novel to familiar place preference ratio1.01.11.6-1.1-1.0-1.31.0-1.0-1.0-1.3-1.01.0-0.90.9
Novelty place preference0.60.61.1-0.8-0.8-1.00.8-0.8-0.8-1.0-0.70.7-0.60.6
Time in novel zone, NPP test0.80.91.4-0.9-0.9-1.10.9-0.9-0.9-1.2-0.90.9-0.70.7
Total zone transitions, NPP test1.72.53.11.41.61.6-1.61.61.61.51.6-1.61.7-1.7
Total locomotion distance, NPP test0.70.91.31.01.10.9-1.01.01.00.81.0-1.00.9-0.7
Locomotion velocity, NPP test0.71.01.31.01.10.9-1.11.11.00.91.0-1.00.9-0.7
Intraocular pressure0.00.00.20.10.4-0.1-0.30.30.2-0.10.2-0.20.00.1
Delta distance traveled before/after self-admin0.40.40.6-0.8-0.4-0.70.7-0.7-0.7-0.6-0.70.7-0.60.6
Delta ambulatory time before/after self-admin0.20.20.4-0.7-0.2-0.50.4-0.4-0.5-0.5-0.50.5-0.60.5
Parametrial fat weight6.715.717.1-4.0-4.0-4.13.9-3.9-3.9-4.1-3.93.9-3.73.9
Pavlov. Cond. lever latency1.11.32.11.41.41.1-1.21.21.21.11.1-1.20.9-0.7
Pavlov. Cond. magazine entry latency0.00.00.2-0.20.10.1-0.00.00.1-0.00.1-0.10.4-0.5
Pavlov. Cond. change in total contacts1.01.12.0-1.4-1.1-1.01.1-1.1-1.1-1.0-1.01.0-0.80.8
Pavlov. Cond. index score0.40.51.1-1.1-0.9-0.70.8-0.8-0.7-0.8-0.70.7-0.40.2
Pavlov. Cond. latency score0.50.61.2-1.1-0.9-0.80.8-0.8-0.8-0.8-0.70.7-0.40.2
Pavlov. Cond. lever contacts0.50.61.2-1.1-1.0-0.70.9-0.8-0.8-0.7-0.80.8-0.50.4
Pavlov. Cond. magazine entry number0.10.20.70.2-0.3-0.30.3-0.3-0.3-0.2-0.40.3-0.50.8
Pavlov. Cond. intertrial magazine entries0.40.51.00.31.00.6-0.80.70.70.80.7-0.70.6-0.7
Pavlov. Cond. lever-magazine prob. diff.0.60.71.5-1.2-1.0-0.80.9-0.9-0.8-0.8-0.80.8-0.50.3
Pavlov. Cond. response bias0.10.20.6-0.8-0.5-0.30.4-0.4-0.4-0.3-0.30.3-0.1-0.1
Pavlov. Cond. lever latency1.92.53.71.91.41.7-1.51.51.51.81.5-1.51.6-1.5
Pavlov. Cond. magazine entry latency1.92.32.8-1.7-1.5-1.51.5-1.5-1.5-1.4-1.51.6-1.61.5
Pavlov. Cond. change in total contacts1.62.53.4-1.8-1.4-1.61.5-1.5-1.5-1.6-1.51.5-1.81.7
Pavlov. Cond. index score1.62.22.8-1.7-1.4-1.51.4-1.4-1.4-1.5-1.41.4-1.61.5
Pavlov. Cond. latency score1.41.82.4-1.5-1.2-1.41.3-1.3-1.3-1.4-1.31.3-1.51.3
Pavlov. Cond. lever contacts2.02.84.0-2.0-1.4-1.81.6-1.6-1.6-1.8-1.61.6-1.71.6
Pavlov. Cond. magazine entry number0.70.91.31.20.91.0-0.90.90.90.90.9-1.01.0-0.9
Pavlov. Cond. intertrial magazine entries1.42.02.31.41.51.4-1.41.41.41.31.4-1.41.5-1.5
Pavlov. Cond. lever-magazine prob. diff.1.72.33.0-1.7-1.4-1.61.5-1.5-1.5-1.6-1.51.5-1.61.5
Pavlov. Cond. response bias1.82.43.4-1.8-1.3-1.61.5-1.5-1.5-1.6-1.51.5-1.61.5
Time in closed arm before self-admin0.10.20.40.10.60.5-0.40.40.40.60.4-0.30.2-0.3
Time in closed arm after self-admin0.20.30.60.50.40.8-0.40.40.50.80.4-0.40.0-0.4
Time in open arm before self-admin0.20.30.6-0.1-0.8-0.60.5-0.5-0.5-0.7-0.50.5-0.40.3
Time in open arm after self-admin3.64.05.4-2.1-1.8-2.31.9-1.9-2.0-2.3-2.01.9-1.62.0
Bone: periosteal estimation0.71.42.1-1.2-1.1-1.31.1-1.1-1.1-1.2-1.21.1-1.51.2
Bone: periosteal perimeter0.81.41.6-1.2-1.0-1.31.2-1.2-1.2-1.3-1.21.2-1.31.1
Bone: post-yield work1.31.92.2-1.3-1.5-1.21.4-1.4-1.4-1.2-1.41.5-1.41.4
Progressive ratio test 1 active lever presses2.43.03.81.31.91.5-1.81.81.81.41.8-1.81.9-1.9
Progressive ratio test 1 breakpoint2.93.64.41.52.01.7-1.91.91.91.62.0-1.92.1-2.1
Progressive ratio test 1 inactive lever presses2.02.93.21.61.81.5-1.81.81.81.51.8-1.81.8-1.7
Progressive ratio test 2 active lever presses0.10.10.3-0.30.40.2-0.30.30.30.10.4-0.30.5-0.6
Progressive ratio test 2 breakpoint0.20.30.5-0.10.60.4-0.50.50.50.30.6-0.50.7-0.7
Progressive ratio test 2 inactive lever presses0.00.10.2-0.20.30.1-0.20.20.20.00.3-0.30.3-0.5
Incentive Sensitization - Responses0.10.20.7-0.8-0.3-0.50.4-0.4-0.4-0.5-0.40.4-0.40.1
Incentive Sensitization - Breakpoint0.30.41.0-1.0-0.4-0.60.6-0.6-0.6-0.6-0.50.6-0.60.3
Sum of active levers in priming session hrs 5-60.70.72.21.50.40.8-0.80.80.80.90.7-0.80.8-0.5
Progressive ratio0.20.30.50.40.70.6-0.60.60.60.50.6-0.50.6-0.6
Food seeking constrained by brief footshock4.55.66.42.22.52.0-2.52.52.51.72.5-2.52.5-2.5
Seeking ratio, punishment vs. effort0.71.01.31.00.90.8-1.01.01.00.81.0-1.11.2-1.1
Retroperitoneal fat weight0.52.03.0-1.7-1.5-1.51.4-1.4-1.3-1.5-1.31.4-1.41.2
Reaction time number correct0.00.00.2-0.10.3-0.1-0.10.10.0-0.1-0.00.0-0.50.4
Reaction time mean minus median0.51.41.8-1.3-1.1-1.31.2-1.2-1.2-1.4-1.11.2-1.00.9
Reaction time mean minus median AUC0.10.30.6-0.5-0.5-0.70.6-0.6-0.6-0.8-0.50.6-0.60.4
Reaction time num false alarms0.20.30.5-0.7-0.4-0.60.5-0.5-0.6-0.5-0.50.5-0.60.5
Reaction time num false alarms AUC0.81.21.9-1.4-0.9-1.11.1-1.1-1.1-0.9-1.11.1-1.11.0
Reaction time trials correct on left0.00.00.2-0.10.3-0.1-0.10.10.0-0.1-0.00.0-0.50.4
Reaction time trials on left0.00.10.3-0.10.2-0.10.0-0.0-0.0-0.1-0.10.1-0.50.4
Reaction time mean0.81.21.5-1.2-1.1-1.01.1-1.1-1.1-1.2-1.11.1-1.21.0
Reaction time mean AUC0.40.60.8-0.8-0.8-0.70.7-0.7-0.7-0.9-0.70.8-0.90.7
Median of all reaction times0.71.01.5-1.0-1.0-0.80.9-0.9-0.9-1.0-1.01.0-1.21.0
Reaction time omissions1.11.62.5-1.6-1.3-1.31.3-1.3-1.3-1.3-1.21.2-0.90.9
Reaction time false alarm rate1.01.31.8-1.3-1.2-1.21.2-1.2-1.2-1.0-1.21.2-1.11.0
Reaction time premature initiation rate0.20.20.50.50.40.7-0.40.40.40.60.4-0.50.7-0.3
Reaction time premature initiations0.30.50.70.70.70.9-0.70.70.70.80.6-0.70.7-0.3
Std. dev. reaction times2.03.74.3-2.0-2.0-1.91.9-1.9-1.9-2.1-1.91.9-1.81.7
Reaction time trials completed0.00.10.3-0.10.2-0.10.0-0.0-0.0-0.1-0.10.1-0.50.4
Reaction time trials AUC0.00.10.3-0.20.2-0.10.0-0.0-0.1-0.2-0.10.1-0.50.4
Run reversals in cocaine runway, females0.00.00.20.4-0.20.10.0-0.00.00.10.0-0.10.1-0.2
Run reversals in cocaine runway, males0.80.81.0-0.7-1.0-0.90.9-0.9-0.9-0.9-0.90.9-1.00.9
Latency to leave start box in cocaine runway0.30.30.40.60.60.5-0.70.70.70.60.7-0.60.4-0.4
Latency to leave start box in cocaine runway, F0.10.10.2-0.4-0.2-0.40.2-0.2-0.2-0.3-0.20.2-0.40.4
Latency to leave start box in cocaine runway, M1.21.11.91.40.91.1-1.11.11.11.21.0-1.00.9-0.9
Std. dev. time between licks in bursts0.00.00.10.3-0.10.2-0.20.20.10.10.1-0.10.40.2
Total sessions with >9 infusions0.91.11.80.81.20.8-1.11.11.10.71.1-1.11.2-1.3
Short access day 1 total inactive lever presses0.10.10.50.30.10.1-0.30.30.30.10.3-0.30.7-0.6
Short access day 10 total inactive lever presses0.71.82.7-0.7-1.7-1.41.4-1.4-1.4-1.2-1.41.3-1.31.4
Short access day 1 total infusions0.30.40.70.60.80.3-0.70.70.70.20.7-0.70.7-0.7
Short access day 10 total infusions0.91.22.00.80.91.1-1.01.01.01.01.1-1.01.4-1.3
Short access total infusions0.40.50.90.40.80.5-0.70.70.70.40.8-0.80.9-0.9
Short access day 1 locomotion0.00.00.1-0.10.1-0.3-0.10.10.1-0.40.1-0.1-0.1-0.3
Short access day 10 total locomotion0.20.40.8-0.9-0.8-0.50.7-0.7-0.6-0.5-0.60.60.00.2
Short access total locomotion0.20.20.60.10.50.3-0.40.40.50.20.5-0.40.8-0.7
One hour access (0.3 mA shock)0.10.10.9-1.0-0.1-0.10.2-0.2-0.2-0.0-0.20.20.0-0.1
Compulsive drug intake3.03.54.4-1.7-1.8-1.91.9-1.9-1.9-1.8-1.91.9-1.82.1
One hour access (shock baseline)1.11.72.50.61.31.3-1.31.31.41.31.4-1.31.4-1.6
Social response proportion0.20.30.9-1.0-0.3-0.50.4-0.4-0.5-0.4-0.50.5-0.40.5
Social responses0.30.31.0-0.20.40.6-0.40.40.50.50.5-0.51.0-0.9
Social time0.10.10.2-0.4-0.2-0.30.2-0.2-0.2-0.3-0.10.10.1-0.5
Soleus weight0.10.20.30.40.40.6-0.30.30.40.40.3-0.30.6-0.3
Bone: stiffness0.00.00.00.20.0-0.0-0.10.10.00.10.0-0.00.10.0
Tibialis anterior weight8.528.830.2-5.3-5.5-5.35.4-5.4-5.4-5.3-5.45.4-5.35.2
Time to tail flick, vehicle, before self-admin2.32.42.7-1.6-1.6-1.61.6-1.6-1.6-1.3-1.61.6-1.61.2
Time to tail flick, vehicle, after self-admin1.01.32.0-1.4-0.8-1.21.0-1.0-1.0-1.4-1.01.1-1.11.3
Time to tail flick, test, before self-admin0.00.00.10.20.1-0.0-0.10.10.10.20.1-0.10.20.1
Time to tail flick, test, after self-admin0.20.20.40.30.60.1-0.60.60.50.30.5-0.60.5-0.3
Delta time to tail flick, vehicle, before/after SA0.80.81.30.91.10.8-1.01.00.90.60.9-0.90.9-0.4
Delta time to tail flick, test, before/after SA0.30.30.6-0.8-0.4-0.80.5-0.5-0.5-0.7-0.50.5-0.60.5
Tibia length3.08.412.33.52.82.9-2.92.92.92.92.9-2.92.6-2.6
Ambulatory time before self-admin0.10.10.4-0.1-0.6-0.30.4-0.4-0.3-0.3-0.40.40.20.6
Ambulatory time after self-admin0.81.01.6-1.2-1.0-0.81.0-1.0-1.0-0.8-1.01.0-0.71.3
Bone: tissue strength0.30.30.7-0.9-0.5-0.50.6-0.6-0.6-0.5-0.60.6-0.10.4
Total heroin consumption0.91.11.81.00.91.1-1.01.01.01.21.0-1.01.4-0.9
Bone: trabecular number0.10.20.30.40.50.3-0.50.40.40.40.5-0.50.5-0.5
Bone: trabecular spacing0.00.00.0-0.1-0.10.1-0.00.00.10.20.0-0.00.1-0.0
Bone: trabecular thickness0.30.30.50.60.70.3-0.60.60.60.40.6-0.60.5-0.5
Bone: trabecular tissue density14.321.122.74.74.84.5-4.64.64.64.44.7-4.64.6-4.5
Water consumed over 24 hours0.00.10.2-0.2-0.50.20.2-0.2-0.20.1-0.20.20.10.3
Number of responses in last shaping day0.10.10.20.1-0.5-0.30.2-0.2-0.1-0.4-0.10.1-0.1-0.2