Kmt5b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	alternative TSS	NM_001108512.2	0.02	0.02	3.8e-03	0.02	0.02	0.02	0.02	4.5e-04	1.3e-03	6.6e-04	8.7e-04
2	pVTA	alternative TSS	NM_001108512.2	0.05	0.04	3.6e-03	0.03	0.01	0.02	0.02	2.9e-03	2.2e-02	4.4e-03	1.8e-02
3	pVTA	isoform ratio	XM_039083671.2	0.04	0.04	8.7e-03	0.03	0.02	0.02	0.02	1.3e-03	1.0e-02	8.3e-03	5.3e-03
4	IC	isoform ratio	XM_039083639.2	0.1	0.08	4.8e-03	0.06	0.06	0.03	0.05	1.1e-03	2.4e-03	1.5e-02	2.9e-03
5	NAcc	alternative polyA	XM_039083671.2	0.02	0.02	4.6e-03	0.02	0.01	0.01	0.01	1.6e-03	1.4e-02	8.9e-03	4.6e-03
6	NAcc	alternative polyA	NM_001108512.2	0.02	0.02	2.9e-03	0.02	0.01	0.01	0.01	1.0e-03	6.9e-03	7.6e-03	2.5e-03
7	Adipose	mRNA stability	Kmt5b	0.04	0.03	8.6e-04	0.01	0.02	0.01	0.02	2.4e-02	2.1e-03	1.0e-02	2.0e-03
8	NAcc	isoform ratio	XM_039083648.2	0.02	0.01	3.0e-03	0.01	0.01	0.01	0	1.5e-02	1.4e-02	2.5e-02	4.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	1.2	2.1	6.6	-0.5	-0.6	0.6	-1.2	-1.2	1.5	2.1	-2.6
Area under the delay curve	0.4	0.5	1.4	-0.1	-0.1	0.1	-0.8	-0.8	0.7	1.1	-1.2
BMI with tail	1.0	3.3	7.9	-2.3	-1.8	1.8	-0.7	-0.7	0.9	2.4	-2.8
BMI without tail	0.4	2.0	4.7	-2.2	-2.0	2.0	0.3	0.3	-0.4	0.9	-1.3
Body weight	1.4	6.1	13.8	-3.7	-3.5	3.5	1.8	1.8	-1.6	0.1	-1.1
Weight adjusted by age	0.4	1.1	1.8	-1.3	-1.2	1.2	1.2	1.2	-1.0	-0.7	0.3
Bone surface	1.2	2.5	6.4	-1.9	-1.8	1.8	-0.3	-0.3	0.6	1.7	-2.5
Bone volume	0.8	1.6	5.1	-0.8	-0.8	0.8	-0.9	-0.9	1.1	1.7	-2.3
Breakpoint value in progressive ratio session	0.8	1.4	2.9	-1.7	-1.6	1.6	1.1	1.1	-0.9	-0.2	-0.3
Number of licking bursts	0.0	0.0	0.1	0.2	-0.0	0.0	-0.0	-0.0	0.2	0.0	-0.4
Context. condit. distance diff. score	0.7	0.9	1.8	1.4	1.0	-1.0	-1.0	-1.0	0.9	0.7	-0.4
Locomotion velocity, session 1	0.0	0.0	0.1	-0.0	0.1	-0.1	-0.0	-0.0	0.3	0.1	-0.1
Locomotion distance, session 1	0.6	0.8	2.6	-0.6	-0.3	0.3	-0.6	-0.6	1.0	1.3	-1.6
Locomotion velocity, session 2	1.4	1.7	3.1	-1.8	-1.7	1.7	1.2	1.2	-1.2	-0.5	0.0
Locomotion distance, session 2	0.3	0.4	1.3	-1.1	-0.6	0.6	0.2	0.2	0.3	0.5	-0.9
Locomotion velocity, session 3	1.0	1.2	2.7	0.1	0.1	-0.1	-1.1	-1.1	1.2	1.6	-1.6
Locomotion distance, session 3	0.1	0.1	0.3	0.2	-0.0	0.0	-0.3	-0.3	0.3	0.6	-0.5
Stereotopy head waving bouts, day 3	1.1	1.3	2.4	0.5	0.2	-0.2	-1.4	-1.4	1.2	1.5	-1.5
Stereotopy head waving duration, day 3	1.1	1.3	2.0	1.0	0.9	-0.9	-1.4	-1.4	1.4	1.1	-1.0
Locomotion velocity, session 7	0.6	0.7	1.8	-0.0	-0.3	0.3	-0.9	-0.9	0.5	1.3	-1.2
Locomotion distance, session 7	0.2	0.3	0.7	-0.5	-0.8	0.8	0.0	0.0	-0.4	0.4	-0.4
Stereotopy head waving bouts, day 7	1.2	1.4	2.3	0.4	0.5	-0.5	-1.4	-1.4	1.5	1.4	-1.5
Stereotopy head waving duration, day 7	0.6	0.7	2.4	-0.7	-0.4	0.4	-0.6	-0.6	0.8	1.1	-1.6
Locomotion velocity, session 8	0.9	1.1	2.2	-1.3	-1.5	1.5	1.0	1.0	-0.9	-0.5	-0.1
Locomotion distance, session 8	0.4	0.6	1.1	0.8	0.7	-0.7	-0.8	-0.8	1.0	0.8	-0.7
Degree of sensitization distance	0.2	0.2	0.5	-0.6	-0.7	0.7	-0.1	-0.1	-0.1	0.5	-0.6
Degree of sensitization stereotypy	0.3	0.3	1.0	-0.3	-0.0	0.0	-0.4	-0.4	0.8	0.6	-1.0
Conditioned locomotion	3.2	3.8	5.7	-1.7	-1.5	1.5	2.4	2.4	-2.2	-2.1	1.6
Cocaine response after cond. corrected	0.1	0.1	0.2	0.3	0.2	-0.2	-0.5	-0.5	0.3	0.4	-0.2
Cocaine response after cond. not corrected	0.3	0.4	0.6	0.3	0.4	-0.4	-0.8	-0.8	0.7	0.8	-0.7
Cocaine response before conditioning	0.0	0.1	0.2	-0.1	0.1	-0.1	-0.1	-0.1	0.4	0.2	-0.4
Saline control response	1.8	2.5	4.5	-2.1	-2.1	2.1	1.5	1.5	-1.4	-0.7	-0.2
Bone: connectivity density	1.4	2.3	6.6	-1.7	-1.6	1.6	-0.4	-0.4	0.8	1.7	-2.6
Bone: cortical apparent density	0.4	0.6	0.9	-0.6	-0.6	0.6	1.0	1.0	-0.9	-0.8	0.7
Bone: cortical area	0.6	1.0	1.8	-0.8	-0.6	0.6	1.3	1.3	-0.9	-1.3	0.8
Bone: cortical porosity	0.0	0.0	0.0	-0.2	-0.0	0.0	-0.0	-0.0	0.1	0.0	-0.2
Bone: cortical porosity	0.2	0.2	0.3	-0.6	-0.5	0.5	0.4	0.4	-0.3	-0.3	-0.1
Bone: cortical thickness	4.8	7.9	12.5	-2.7	-2.2	2.2	3.5	3.5	-2.8	-3.0	2.1
Bone: cortical thickness	1.7	2.0	3.0	-1.6	-1.3	1.3	1.7	1.7	-1.3	-1.4	0.8
Bone: cortical tissue density	0.5	0.9	1.2	-0.8	-0.8	0.8	1.1	1.1	-1.1	-0.8	0.8
Condit. Reinf. active minus inactive responses	0.3	0.3	0.7	-0.2	0.2	-0.2	-0.4	-0.4	0.9	0.7	-0.8
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.7	0.2	0.4	-0.4	-0.6	-0.6	0.9	0.7	-0.6
Condit. Reinf. active responses	0.1	0.1	0.4	0.0	0.4	-0.4	-0.2	-0.2	0.6	0.4	-0.3
Condit. Reinf. inactive responses	0.0	0.1	0.1	0.3	0.3	-0.3	-0.1	-0.1	0.0	-0.1	0.3
Incentive salience index mean	0.2	0.2	0.6	-0.3	0.2	-0.2	-0.2	-0.2	0.8	0.5	-0.6
Condit. Reinf. lever presses	0.0	0.1	0.1	-0.0	0.2	-0.2	0.3	0.3	0.2	-0.3	0.1
Condit. Reinf. active minus inactive responses	1.4	2.1	3.8	0.9	1.2	-1.2	-1.6	-1.6	1.9	1.7	-1.4
Condit. Reinf. active-inactive response ratio	1.9	3.0	4.5	1.5	2.0	-2.0	-1.7	-1.7	2.1	1.4	-0.9
Condit. Reinf. active responses	1.1	1.6	3.2	0.2	0.3	-0.3	-1.4	-1.4	1.5	1.8	-1.7
Condit. Reinf. inactive responses	0.5	0.8	1.6	-1.0	-1.3	1.3	-0.1	-0.1	-0.0	0.8	-1.1
Condit. Reinf. lever presses	0.4	0.6	1.8	-0.7	-0.5	0.5	-0.3	-0.3	0.7	1.0	-1.3
Condit. Reinf. lever reinforcers received	1.0	1.4	3.2	-0.0	0.0	-0.0	-1.2	-1.2	1.4	1.8	-1.8
Conditioned reinforcement - actives	0.1	0.3	1.2	0.4	0.5	-0.5	-0.0	-0.0	-0.5	-0.5	1.1
Conditioned reinforcement - inactives	1.2	3.2	4.3	2.1	2.1	-2.1	-2.0	-2.0	1.8	1.2	-0.3
Conditioned locomotion	4.4	6.6	13.1	3.6	3.6	-3.6	-2.1	-2.1	2.0	0.5	0.8
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.7	0.2	-0.2	-0.7	-0.7	0.3	0.3	-0.2
Patch foraging indifference point AUC	0.5	1.2	2.1	-1.1	-0.8	0.8	1.5	1.5	-1.1	-1.0	0.9
Delay disc. indifference point, 0s delay	1.4	1.6	3.1	0.0	0.1	-0.1	-1.5	-1.5	1.4	1.7	-1.8
Delay disc. indifference point, 16s delay	0.7	1.0	1.4	1.1	1.2	-1.2	-1.0	-1.0	1.1	0.6	-0.4
Delay disc. indifference point, 2s delay	0.6	0.7	1.0	0.7	0.6	-0.6	-1.0	-1.0	1.0	0.9	-0.9
Delay disc. indifference point, 24s delay	0.2	0.3	0.6	-0.3	-0.3	0.3	0.4	0.4	-0.8	-0.6	0.6
Delay disc. indifference point, 4s delay	0.2	0.3	0.8	-0.2	-0.1	0.1	-0.4	-0.4	0.5	0.8	-0.9
Delay disc. indifference point, 8s delay	0.1	0.2	0.5	-0.3	-0.5	0.5	-0.4	-0.4	0.2	0.6	-0.7
Indifference point function ln k	1.1	3.2	6.5	2.6	2.3	-2.3	-1.8	-1.8	1.4	0.6	0.2
Indifference point function log k	1.1	3.2	6.5	2.6	2.3	-2.3	-1.8	-1.8	1.4	0.6	0.2
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	0.3	-0.2	0.2	-0.1	-0.1	-0.5	-0.3	0.3
Patch foraging total patch changes 12 sec	1.6	2.1	3.8	-1.9	-1.9	1.9	1.4	1.4	-1.4	-0.6	0.1
Patch foraging total patch changes 18 sec	0.1	0.3	0.7	-0.6	-0.8	0.8	0.3	0.3	-0.4	0.1	-0.2
Patch foraging total patch changes 24 sec	0.4	1.3	2.1	-1.1	-1.2	1.2	1.1	1.1	-1.4	-0.7	0.7
Patch foraging total patch changes 6 sec	0.4	0.8	1.7	-1.3	-1.3	1.3	0.2	0.2	-0.4	0.5	-0.8
Patch foraging time to switch 0 sec	0.4	1.6	4.7	-1.3	-1.3	1.3	-0.5	-0.5	0.7	1.3	-2.2
Patch foraging water rate 0 sec	0.8	3.0	6.2	2.4	2.2	-2.2	-0.0	-0.0	-0.4	-1.5	2.5
Patch foraging water rate 12 sec	1.2	4.7	10.3	3.2	3.1	-3.1	-0.4	-0.4	0.3	-1.3	2.5
Patch foraging water rate 18 sec	0.5	1.1	2.5	1.5	1.6	-1.6	-0.4	-0.4	0.5	-0.4	0.8
Patch foraging water rate 24 sec	1.3	1.8	4.4	1.6	1.6	-1.6	0.2	0.2	-0.6	-1.4	2.1
Patch foraging water rate 6 sec	1.1	1.6	4.0	1.5	1.2	-1.2	0.5	0.5	-0.8	-1.5	2.0
Seeking ratio, delayed vs. immediate footshock	0.4	0.6	1.2	-0.2	0.0	-0.0	-0.9	-0.9	0.8	1.1	-1.1
Distance traveled before self-admin	0.1	0.2	0.6	-0.1	0.0	-0.0	-0.2	-0.2	0.7	0.6	-0.8
Distance traveled after self-admin	0.0	0.0	0.0	-0.1	-0.0	0.0	0.1	0.1	0.2	-0.1	-0.2
Extensor digitorum longus weight	5.2	20.6	33.4	-5.8	-5.5	5.5	4.6	4.6	-4.6	-2.5	1.0
Bone: elastic displacement	1.5	1.9	4.6	-0.0	0.0	-0.0	1.5	1.5	-1.4	-2.0	2.2
Bone: elastic work	2.5	3.3	4.6	-1.7	-1.6	1.6	2.2	2.2	-2.0	-1.8	1.3
Bone: endosteal estimation	1.5	3.6	5.5	1.9	1.4	-1.4	-2.3	-2.3	2.0	2.0	-1.5
Bone: endosteal perimeter	3.2	7.9	11.4	2.7	2.3	-2.3	-3.4	-3.4	3.1	2.9	-2.2
Epididymis fat weight	1.8	9.1	16.7	4.0	4.1	-4.1	-2.7	-2.7	2.8	0.8	0.3
Delta time in closed arm before/after self-admin	1.2	1.1	1.5	-1.1	-1.1	1.1	1.1	1.1	-1.2	-0.7	0.5
Delta time in open arm before/after self-admin	0.3	0.3	0.8	0.1	0.4	-0.4	-0.5	-0.5	0.9	0.6	-0.7
Diff in mean of infusions in LGA sessions	0.4	0.7	1.2	-1.0	-0.8	0.8	1.1	1.1	-0.8	-0.8	0.3
Delay discount exponential model param	0.3	0.3	1.0	0.1	0.2	-0.2	0.6	0.6	-0.5	-0.9	1.0
Extinction: sum of active levers before priming	0.6	0.9	2.3	-1.5	-1.3	1.3	0.2	0.2	-0.2	0.5	-0.9
Active lever presses in extinction session 6	1.1	1.1	1.6	-1.1	-1.1	1.1	1.3	1.3	-1.1	-0.7	0.5
Bone: final force	0.6	1.0	2.1	-1.5	-1.4	1.4	0.8	0.8	-0.6	-0.1	-0.5
Bone: final moment	0.6	1.0	2.0	-1.4	-1.4	1.4	0.8	0.8	-0.6	-0.2	-0.4
Food consumed during 24 hour testing period	0.2	0.3	0.6	0.7	0.8	-0.8	0.1	0.1	0.3	-0.6	0.6
Glucose	3.4	5.4	7.7	1.7	1.9	-1.9	-2.7	-2.7	2.8	2.5	-2.1
Heart weight	1.2	1.9	3.3	0.5	0.4	-0.4	-1.7	-1.7	1.6	1.7	-1.8
Delay discount hyperbolic model param	0.3	0.4	1.1	0.0	0.1	-0.1	0.7	0.7	-0.6	-1.0	1.1
Intermittent access intake day 1-15 change	0.5	2.6	5.2	2.1	2.3	-2.3	-1.3	-1.3	1.4	-0.0	0.4
Intermittent access intake escalation	0.4	2.1	4.6	2.0	2.1	-2.1	-1.0	-1.0	1.2	-0.2	0.5
Intermittent access intake escalation 2	1.0	1.7	3.6	1.7	1.9	-1.9	-1.1	-1.1	1.2	0.1	0.3
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	0.0	0.1	-0.1	-0.4	-0.4	-0.1	0.2	0.1
Intermitt. access day 15 inactive lever presses	0.5	2.6	4.6	1.3	1.4	-1.4	-2.1	-2.1	1.8	1.4	-0.9
Intermitt. access escalation Index	0.5	1.7	4.0	2.0	1.9	-1.9	-0.3	-0.3	0.7	-0.6	0.9
Intermittent access day 1 total infusions	1.7	5.1	8.4	1.3	1.3	-1.3	-2.9	-2.9	2.6	2.7	-2.1
Intermittent access day 15 total infusions	2.7	6.6	8.5	2.8	2.9	-2.9	-2.9	-2.9	2.8	1.7	-0.8
Intermittent access terminal intake (last 3 days)	3.6	6.3	9.1	2.4	2.5	-2.5	-3.0	-3.0	2.8	2.1	-1.3
Intermittent access total infusions	3.7	4.4	6.9	1.7	1.8	-1.8	-2.6	-2.6	2.4	2.1	-1.4
Intermittent access day 1 locomotion	1.3	2.5	4.1	1.0	0.9	-0.9	-2.0	-2.0	1.7	2.0	-1.3
Intermittent access day 15 total locomotion	1.5	6.0	7.8	2.7	2.8	-2.8	-2.6	-2.6	2.8	1.6	-0.9
Intermittent access total locomotion	7.2	8.7	11.3	3.0	3.1	-3.1	-3.4	-3.4	3.4	2.3	-1.3
Intermittent access standard deviation	0.2	0.9	1.4	1.0	1.2	-1.2	-1.0	-1.0	1.2	0.5	-0.3
Left kidney weight	0.4	3.5	6.4	2.3	2.5	-2.5	-1.7	-1.7	2.0	0.7	-0.2
Right kidney weight	0.3	2.1	5.1	1.8	2.2	-2.2	-0.8	-0.8	1.2	-0.3	0.6
Cocaine induced anxiety	0.0	0.1	0.2	0.3	0.2	-0.2	-0.3	-0.3	0.5	0.3	-0.4
Post-drug Anxiety	0.2	0.2	0.5	-0.7	-0.7	0.7	0.3	0.3	-0.2	0.0	-0.3
Baseline Anxiety	0.3	0.6	1.0	-1.0	-0.8	0.8	0.8	0.8	-0.9	-0.5	0.3
Tail length	0.8	4.5	6.9	-1.7	-2.1	2.1	2.3	2.3	-2.6	-2.0	1.5
Length with tail	2.1	9.4	11.6	-3.2	-3.4	3.4	3.4	3.4	-3.4	-2.4	1.3
Length without tail	1.1	5.7	8.1	-2.8	-2.6	2.6	2.7	2.7	-2.4	-1.8	0.8
Times rat made contact with spout	0.2	0.3	0.8	-0.6	-0.5	0.5	-0.0	-0.0	0.4	0.5	-0.9
Lifetime Intake	2.2	2.8	4.8	1.2	1.3	-1.3	-2.2	-2.2	1.8	1.8	-1.1
Liver weight, left	0.2	0.3	1.0	0.7	0.5	-0.5	0.2	0.2	-0.5	-0.8	1.0
Liver weight, right	0.5	0.8	2.0	1.4	1.3	-1.3	-0.4	-0.4	0.3	-0.4	0.8
Locomotor activity	0.5	0.8	2.0	1.1	1.4	-1.4	-0.2	-0.2	0.4	-0.5	0.8
Locomotor testing distance	0.4	0.9	2.2	1.2	1.5	-1.5	-0.3	-0.3	0.3	-0.5	0.9
Locomotor testing rearing	0.4	1.6	2.5	1.3	1.6	-1.6	-1.2	-1.2	1.5	0.9	-0.5
Locomotion in novel chamber	4.3	5.8	8.5	2.9	2.9	-2.9	-2.5	-2.5	2.6	1.3	-0.6
Locomotion in novel chamber post-restriction	1.1	3.4	5.7	2.4	2.3	-2.3	-1.9	-1.9	1.8	0.8	-0.2
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	0.3	0.4	-0.4	-0.2	-0.2	0.3	-0.0	0.1
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	-0.3	-0.6	0.6	-0.0	-0.0	-0.2	0.2	-0.3
Time >=10cm from walls, locomotor time 1	2.8	3.5	5.7	1.3	1.2	-1.2	-2.4	-2.4	2.1	2.2	-1.6
Bouts of movement, locomotor time 1	1.4	1.9	3.0	-0.8	-1.2	1.2	1.6	1.6	-1.7	-1.4	1.0
Total resting periods, locomotor time 1	1.1	1.2	2.1	-0.4	-0.7	0.7	1.4	1.4	-1.4	-1.3	1.0
Rest time, locomotor task time 1	0.7	1.1	2.6	1.4	1.6	-1.6	-0.3	-0.3	0.2	-0.6	1.0
Distance moved, locomotor task time 1	0.2	0.7	1.8	-0.3	-0.2	0.2	-0.7	-0.7	1.1	1.2	-1.3
Vertical activity count, locomotor time 1	0.2	1.2	2.2	0.9	0.8	-0.8	-1.3	-1.3	1.5	1.1	-0.9
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.3	0.4	0.4	-0.4	-0.3	-0.3	-0.2	-0.0	0.5
Bouts of movement, locomotor time 2	0.1	0.4	0.7	-0.8	-0.9	0.9	0.5	0.5	-0.7	-0.2	0.2
Total resting periods, locomotor time 2	0.0	0.1	0.3	-0.4	-0.5	0.5	0.2	0.2	-0.3	0.0	-0.1
Rest time, locomotor task time 2	1.4	2.3	3.8	1.5	1.7	-1.7	-1.6	-1.6	2.0	1.1	-0.9
Distance moved, locomotor task time 2	1.1	1.4	2.0	-1.1	-1.0	1.0	1.4	1.4	-1.4	-1.2	0.9
Vertical activity count, locomotor time 2	0.7	1.7	3.5	-0.3	-0.5	0.5	1.4	1.4	-1.7	-1.7	1.9
Light reinforcement 1	0.1	0.6	1.3	1.0	1.2	-1.2	-0.3	-0.3	0.5	-0.3	0.6
Light reinforcement 2	0.8	1.8	4.1	1.9	2.0	-2.0	-0.9	-0.9	1.1	-0.0	0.6
Bone: marrow area	1.5	3.8	5.7	2.0	1.5	-1.5	-2.4	-2.4	2.0	2.0	-1.6
Bone: maximum diameter	0.1	0.2	0.4	0.6	0.6	-0.6	-0.0	-0.0	0.3	-0.3	0.3
Bone: maximum force	0.7	1.4	3.4	-1.5	-1.4	1.4	-0.2	-0.2	0.4	1.2	-1.8
Bone: maximum moment	0.7	1.2	2.8	-1.4	-1.4	1.4	-0.1	-0.1	0.3	1.1	-1.7
Mean time between licks in bursts	0.1	0.7	1.2	-0.9	-1.1	1.1	0.7	0.7	-0.9	-0.3	0.1
Mean num. licks in bursts	0.0	0.1	0.2	-0.3	-0.0	0.0	-0.3	-0.3	0.3	0.5	-0.3
Cd content in liver	1.3	1.5	2.8	1.7	1.5	-1.5	-1.2	-1.2	1.1	0.6	-0.2
Co content in liver	0.9	1.0	3.1	0.4	0.8	-0.8	0.8	0.8	-0.7	-1.3	1.8
Cu content in liver	0.0	0.0	0.1	0.1	0.0	-0.0	-0.2	-0.2	-0.3	0.2	0.2
Fe content in liver	0.1	0.1	0.3	-0.5	-0.3	0.3	0.3	0.3	-0.3	-0.1	0.2
K content in liver	0.2	0.2	0.5	-0.7	-0.4	0.4	-0.0	-0.0	0.2	0.5	-0.7
Mg content in liver	0.6	0.7	1.0	0.6	0.8	-0.8	-0.9	-0.9	1.0	0.8	-0.6
Mn content in liver	1.2	1.4	2.7	-1.6	-1.6	1.6	1.1	1.1	-1.0	-0.3	-0.1
Na content in liver	0.4	0.5	1.1	0.1	0.1	-0.1	0.8	0.8	-0.7	-1.0	1.0
Rb content in liver	1.8	2.1	2.9	1.2	1.3	-1.3	-1.7	-1.7	1.7	1.5	-1.1
Se content in liver	0.4	0.5	0.9	0.4	0.2	-0.2	-0.9	-0.9	0.6	0.9	-0.8
Sr content in liver	2.4	2.1	2.8	-1.4	-1.4	1.4	1.7	1.7	-1.5	-1.3	1.0
Zn content in liver	0.6	0.7	1.3	-0.7	-0.8	0.8	0.9	0.9	-1.2	-0.8	0.7
Bone: minimum diameter	1.9	3.6	5.5	1.4	1.4	-1.4	-2.2	-2.2	2.4	2.1	-1.9
Time in familiar zone, hab. session 1	0.6	0.7	0.9	0.9	0.8	-0.8	-0.9	-0.9	0.9	0.9	-0.6
Time in novel zone, hab. session 1	0.1	0.1	0.3	-0.3	-0.3	0.3	0.4	0.4	-0.4	-0.5	0.3
Total zone transitions, hab. session 1	0.1	0.2	0.7	-0.8	-0.4	0.4	0.4	0.4	0.1	-0.1	-0.4
Total locomotion distance, hab. session 1	0.5	0.7	1.2	0.8	1.1	-1.1	-0.8	-0.8	1.0	0.5	-0.3
Locomotion velocity, hab. session 1	0.2	0.3	0.6	0.4	0.8	-0.8	-0.4	-0.4	0.7	0.2	-0.2
Time in familiar zone, hab. session 2	0.8	0.9	1.5	-0.5	-0.8	0.8	1.2	1.2	-1.1	-1.1	0.8
Time in novel zone, hab. session 2	0.7	0.8	1.5	0.0	0.2	-0.2	-1.1	-1.1	1.0	1.2	-1.2
Total zone transitions, hab. session 2	1.6	2.0	6.1	-1.1	-0.9	0.9	-1.0	-1.0	1.1	2.0	-2.5
Total locomotion distance, hab. session 2	0.9	1.1	2.5	0.1	0.2	-0.2	-1.2	-1.2	1.3	1.5	-1.6
Locomotion velocity, hab. session 2	1.1	1.4	2.4	0.4	0.6	-0.6	-1.4	-1.4	1.5	1.5	-1.5
Novel to familiar place preference ratio	0.2	0.2	0.6	-0.3	-0.5	0.5	-0.4	-0.4	0.2	0.5	-0.8
Novelty place preference	0.2	0.3	0.7	-0.0	-0.2	0.2	-0.6	-0.6	0.4	0.7	-0.8
Time in novel zone, NPP test	0.2	0.3	0.8	-0.1	-0.2	0.2	-0.6	-0.6	0.4	0.6	-0.9
Total zone transitions, NPP test	0.4	0.6	1.6	-1.0	-0.9	0.9	-0.0	-0.0	0.3	0.8	-1.3
Total locomotion distance, NPP test	0.3	0.4	0.8	0.2	0.3	-0.3	-0.7	-0.7	0.9	0.9	-0.8
Locomotion velocity, NPP test	0.2	0.3	0.5	0.3	0.3	-0.3	-0.5	-0.5	0.7	0.7	-0.6
Intraocular pressure	0.5	0.8	1.8	0.7	1.1	-1.1	0.4	0.4	-0.2	-1.1	1.4
Delta distance traveled before/after self-admin	0.1	0.1	0.4	-0.1	-0.1	0.1	0.4	0.4	-0.4	-0.6	0.5
Delta ambulatory time before/after self-admin	0.2	0.3	0.5	-0.3	-0.2	0.2	0.6	0.6	-0.6	-0.7	0.6
Parametrial fat weight	2.4	5.7	7.8	2.8	2.7	-2.7	-2.6	-2.6	2.6	1.6	-0.9
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.4	0.6	-0.6	-0.3	-0.3	0.1	-0.1	0.3
Pavlov. Cond. magazine entry latency	0.5	0.7	1.5	0.4	0.1	-0.1	-1.0	-1.0	0.9	1.1	-1.2
Pavlov. Cond. change in total contacts	0.7	0.7	1.2	0.8	0.7	-0.7	-0.9	-0.9	1.1	0.8	-0.7
Pavlov. Cond. index score	0.1	0.1	0.2	0.4	0.3	-0.3	-0.1	-0.1	0.4	0.1	-0.2
Pavlov. Cond. latency score	0.1	0.1	0.2	0.3	0.1	-0.1	-0.2	-0.2	0.4	0.3	-0.4
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.0	-0.1	0.1	0.1	0.1	0.3	0.2	-0.3
Pavlov. Cond. magazine entry number	0.0	0.0	0.2	-0.5	-0.2	0.2	0.1	0.1	-0.2	0.1	0.0
Pavlov. Cond. intertrial magazine entries	0.2	0.3	1.0	0.3	0.4	-0.4	0.4	0.4	-0.3	-0.7	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.4	0.3	-0.3	-0.1	-0.1	0.5	0.1	-0.2
Pavlov. Cond. response bias	0.0	0.0	0.2	0.4	0.2	-0.2	0.0	0.0	0.2	-0.3	0.1
Pavlov. Cond. lever latency	0.1	0.1	0.1	-0.1	-0.3	0.3	-0.3	-0.3	-0.4	0.3	-0.0
Pavlov. Cond. magazine entry latency	1.1	1.6	3.5	-1.9	-1.7	1.7	0.4	0.4	0.0	0.7	-1.5
Pavlov. Cond. change in total contacts	0.2	0.4	1.4	-0.2	-0.3	0.3	-0.5	-0.5	0.8	0.8	-1.2
Pavlov. Cond. index score	0.2	0.4	1.0	-0.8	-0.7	0.7	0.1	0.1	0.4	0.4	-1.0
Pavlov. Cond. latency score	0.2	0.3	0.7	-0.6	-0.6	0.6	0.1	0.1	0.4	0.3	-0.8
Pavlov. Cond. lever contacts	0.0	0.1	0.2	-0.0	0.2	-0.2	0.2	0.2	0.5	-0.2	-0.1
Pavlov. Cond. magazine entry number	1.5	2.0	4.4	2.1	2.0	-2.0	-0.5	-0.5	0.1	-0.7	1.6
Pavlov. Cond. intertrial magazine entries	0.3	0.6	2.1	1.4	1.0	-1.0	-0.7	-0.7	0.2	-0.0	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.5	1.1	-1.0	-0.9	0.9	0.2	0.2	0.2	0.4	-1.0
Pavlov. Cond. response bias	0.3	0.4	1.0	-0.8	-0.5	0.5	0.2	0.2	0.5	0.4	-1.0
Time in closed arm before self-admin	0.7	1.2	1.7	0.9	0.9	-0.9	-1.3	-1.3	1.3	1.2	-0.9
Time in closed arm after self-admin	0.0	0.0	0.1	0.2	0.2	-0.2	-0.1	-0.1	-0.1	-0.0	0.2
Time in open arm before self-admin	1.1	1.3	1.9	-0.8	-1.0	1.0	1.3	1.3	-1.4	-1.3	0.9
Time in open arm after self-admin	0.3	0.3	0.6	-0.8	-0.8	0.8	0.6	0.6	-0.3	-0.2	-0.3
Bone: periosteal estimation	0.1	0.2	0.4	0.6	0.5	-0.5	-0.6	-0.6	0.6	0.3	-0.4
Bone: periosteal perimeter	0.4	0.7	1.1	0.6	0.4	-0.4	-1.0	-1.0	1.0	1.0	-1.0
Bone: post-yield work	4.6	7.9	16.1	0.6	0.5	-0.5	-3.2	-3.2	3.1	4.0	-4.0
Progressive ratio test 1 active lever presses	0.0	0.1	0.2	0.1	0.1	-0.1	-0.4	-0.4	-0.2	0.4	0.3
Progressive ratio test 1 breakpoint	0.0	0.1	0.1	0.1	0.1	-0.1	-0.4	-0.4	-0.2	0.4	0.3
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	0.1	0.1	-0.1	-0.6	-0.6	-0.0	0.6	0.1
Progressive ratio test 2 active lever presses	1.4	1.9	3.0	1.4	1.4	-1.4	-1.7	-1.7	1.3	1.2	-0.4
Progressive ratio test 2 breakpoint	1.3	1.7	2.6	1.3	1.4	-1.4	-1.6	-1.6	1.2	1.1	-0.3
Progressive ratio test 2 inactive lever presses	2.5	8.0	11.6	3.0	3.1	-3.1	-3.4	-3.4	2.7	2.0	-0.6
Incentive Sensitization - Responses	0.2	0.5	1.1	-0.1	-0.0	0.0	-0.8	-0.8	0.8	1.0	-1.0
Incentive Sensitization - Breakpoint	0.2	0.6	1.1	0.1	0.2	-0.2	-0.9	-0.9	0.9	1.1	-1.0
Sum of active levers in priming session hrs 5-6	2.3	2.2	5.0	0.1	0.1	-0.1	1.6	1.6	-1.6	-2.2	2.2
Progressive ratio	0.8	2.3	6.9	-1.0	-1.1	1.1	-1.2	-1.2	1.1	2.1	-2.6
Food seeking constrained by brief footshock	0.2	0.2	0.5	-0.5	-0.7	0.7	-0.0	-0.0	-0.3	0.2	-0.4
Seeking ratio, punishment vs. effort	0.6	1.2	3.5	1.0	0.9	-0.9	0.7	0.7	-0.8	-1.5	1.9
Retroperitoneal fat weight	5.1	22.6	39.5	6.3	6.3	-6.3	-4.4	-4.4	4.6	1.7	-0.2
Reaction time number correct	0.2	0.8	1.5	-0.5	-0.4	0.4	1.2	1.2	-0.8	-1.1	0.9
Reaction time mean minus median	0.1	0.8	2.4	-1.5	-1.1	1.1	0.6	0.6	-0.2	0.3	-0.7
Reaction time mean minus median AUC	0.1	0.8	2.1	-1.4	-0.9	0.9	1.1	1.1	-0.5	-0.3	-0.0
Reaction time num false alarms	0.5	0.9	1.8	-0.2	-0.2	0.2	1.1	1.1	-1.1	-1.3	1.2
Reaction time num false alarms AUC	0.6	1.4	2.1	-0.9	-0.9	0.9	1.4	1.4	-1.4	-1.3	1.0
Reaction time trials correct on left	0.2	0.8	1.5	-0.5	-0.4	0.4	1.2	1.2	-0.8	-1.1	0.9
Reaction time trials on left	0.3	1.0	1.9	-0.7	-0.5	0.5	1.4	1.4	-1.0	-1.2	1.0
Reaction time mean	0.1	0.3	0.6	0.1	0.1	-0.1	-0.6	-0.6	0.6	0.7	-0.8
Reaction time mean AUC	0.2	0.4	0.8	0.2	0.2	-0.2	-0.8	-0.8	0.8	0.8	-0.9
Median of all reaction times	0.4	0.7	1.1	0.5	0.3	-0.3	-1.0	-1.0	0.9	0.9	-1.0
Reaction time omissions	0.9	1.5	3.4	-1.8	-1.5	1.5	1.3	1.3	-0.8	-0.4	-0.1
Reaction time false alarm rate	0.3	0.5	0.8	-0.4	-0.5	0.5	0.7	0.7	-0.9	-0.8	0.7
Reaction time premature initiation rate	1.6	2.5	4.7	-2.2	-2.1	2.1	1.4	1.4	-1.5	-0.4	-0.0
Reaction time premature initiations	1.4	4.4	6.5	-2.5	-2.4	2.4	2.3	2.3	-2.2	-1.2	0.7
Std. dev. reaction times	0.1	0.2	0.6	-0.8	-0.5	0.5	0.1	0.1	0.2	0.4	-0.6
Reaction time trials completed	0.3	1.0	1.9	-0.7	-0.5	0.5	1.4	1.4	-1.0	-1.2	1.0
Reaction time trials AUC	0.2	0.8	1.4	-0.5	-0.5	0.5	1.2	1.2	-0.9	-1.1	0.9
Run reversals in cocaine runway, females	0.5	0.6	1.2	-1.0	-0.9	0.9	-0.2	-0.2	0.2	0.9	-1.1
Run reversals in cocaine runway, males	0.6	0.7	1.7	-0.5	0.3	-0.3	1.1	1.1	-0.4	-1.3	1.0
Latency to leave start box in cocaine runway	0.7	1.0	1.8	0.4	0.3	-0.3	-1.2	-1.2	1.2	1.3	-1.3
Latency to leave start box in cocaine runway, F	0.5	0.6	1.5	0.1	0.1	-0.1	-0.7	-0.7	1.1	1.0	-1.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.1	-0.2	0.2	-0.4	-0.4	0.0	0.4	-0.2
Std. dev. time between licks in bursts	1.0	1.8	2.9	-0.7	-0.9	0.9	1.7	1.7	-1.6	-1.6	1.4
Total sessions with >9 infusions	0.2	0.3	0.8	-0.4	-0.4	0.4	-0.5	-0.5	0.1	0.9	-0.4
Short access day 1 total inactive lever presses	0.8	1.5	2.2	1.5	1.5	-1.5	-1.4	-1.4	1.1	0.7	-0.1
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.0	0.0	-0.0	-0.4	-0.4	0.1	0.2	-0.2
Short access day 1 total infusions	0.7	1.3	2.6	0.8	1.0	-1.0	-1.6	-1.6	1.1	1.2	-0.4
Short access day 10 total infusions	1.2	1.9	4.5	0.1	0.1	-0.1	-1.7	-1.7	1.4	2.1	-1.7
Short access total infusions	0.6	0.9	2.2	-0.1	0.0	-0.0	-1.3	-1.3	0.8	1.5	-1.0
Short access day 1 locomotion	0.7	1.2	1.8	1.1	1.0	-1.0	-1.4	-1.4	1.1	1.1	-0.4
Short access day 10 total locomotion	0.3	1.1	1.8	0.7	0.8	-0.8	-1.2	-1.2	1.3	1.3	-1.0
Short access total locomotion	1.0	1.4	2.3	1.0	1.0	-1.0	-1.5	-1.5	1.3	1.4	-0.7
One hour access (0.3 mA shock)	3.9	4.6	6.5	2.3	2.4	-2.4	-2.6	-2.6	2.1	1.6	-0.5
Compulsive drug intake	2.2	3.3	5.5	-1.9	-2.0	2.0	1.8	1.8	-2.3	-1.3	1.1
One hour access (shock baseline)	2.6	6.9	10.0	3.0	3.2	-3.2	-2.8	-2.8	2.7	1.7	-0.6
Social response proportion	0.2	0.2	0.6	-0.6	-0.5	0.5	0.0	0.0	0.2	0.5	-0.8
Social responses	0.3	0.4	0.8	-0.6	-0.4	0.4	0.9	0.9	-0.5	-0.4	0.4
Social time	0.2	0.4	0.9	-0.9	-0.7	0.7	0.7	0.7	-0.5	-0.0	-0.0
Soleus weight	1.8	5.3	13.2	3.6	3.3	-3.3	-1.5	-1.5	1.2	-0.4	1.5
Bone: stiffness	0.6	1.1	3.6	-1.0	-0.9	0.9	-0.5	-0.5	0.6	1.3	-1.9
Tibialis anterior weight	7.9	27.4	34.6	-5.8	-5.3	5.3	5.9	5.9	-5.7	-4.2	2.9
Time to tail flick, vehicle, before self-admin	0.5	0.6	2.4	-0.5	-0.4	0.4	-0.5	-0.5	0.8	0.8	-1.6
Time to tail flick, vehicle, after self-admin	0.5	1.1	2.1	-1.4	-1.2	1.2	-0.2	-0.2	0.3	1.3	-1.5
Time to tail flick, test, before self-admin	1.9	2.2	3.7	0.8	0.7	-0.7	-1.8	-1.8	1.8	1.9	-1.7
Time to tail flick, test, after self-admin	0.2	0.2	0.4	0.2	-0.2	0.2	0.5	0.5	-0.4	-0.6	0.3
Delta time to tail flick, vehicle, before/after SA	0.3	0.4	0.8	-0.9	-0.9	0.9	0.1	0.1	-0.3	0.7	-0.4
Delta time to tail flick, test, before/after SA	3.7	4.6	8.2	-0.8	-1.0	1.0	2.6	2.6	-2.6	-2.9	2.4
Tibia length	0.6	1.6	3.3	-0.5	-0.3	0.3	1.5	1.5	-1.3	-1.8	1.6
Ambulatory time before self-admin	0.1	0.4	1.2	0.0	0.1	-0.1	-0.6	-0.6	1.0	0.9	-1.1
Ambulatory time after self-admin	0.8	1.2	2.2	0.9	0.9	-0.9	-1.3	-1.3	1.5	1.0	-1.0
Bone: tissue strength	0.5	0.5	1.1	0.3	0.8	-0.8	-0.6	-0.6	1.1	0.5	-0.6
Total heroin consumption	2.7	3.2	5.6	-2.4	-2.3	2.3	1.7	1.7	-1.7	-0.7	0.1
Bone: trabecular number	1.0	1.9	5.9	-0.6	-0.7	0.7	-1.1	-1.1	1.3	1.9	-2.4
Bone: trabecular spacing	0.3	0.4	1.4	0.5	0.3	-0.3	0.3	0.3	-0.8	-0.7	1.2
Bone: trabecular thickness	1.2	1.7	2.8	0.5	0.6	-0.6	-1.5	-1.5	1.7	1.5	-1.7
Bone: trabecular tissue density	2.3	4.1	9.6	3.1	2.9	-2.9	-1.0	-1.0	0.9	-0.7	1.5
Water consumed over 24 hours	0.3	0.6	1.3	-1.1	-1.1	1.1	0.3	0.3	-0.3	0.1	-0.7
Number of responses in last shaping day	0.1	0.1	0.2	-0.3	-0.3	0.3	0.1	0.1	-0.5	0.1	0.3