Rbm4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Rbm4	0.04	0.03	1.1e-03	0	0.01	0.01	0.01	9.9e-02	2.4e-02	4.1e-02	4.7e-02
2	NAcc	intron excision ratio	chr1_211508086_211515412	0.04	0.04	5.5e-04	0.01	0.01	0.01	0.01	3.3e-02	6.8e-03	1.6e-02	2.1e-02
3	Brain	intron excision ratio	chr1_211508086_211515412	0.03	0.02	7.1e-03	0.01	0.03	0.02	0.03	2.0e-02	2.1e-03	3.2e-03	1.5e-03
4	PL	gene expression	Rbm4	0.08	0.06	3.9e-05	0.02	0.04	0.02	0.04	2.1e-03	8.8e-05	5.1e-03	4.2e-05
5	Brain	gene expression	Rbm4	0.16	0.09	9.2e-09	0.07	0.1	0.1	0.1	2.4e-07	1.2e-09	2.9e-09	1.7e-09
6	NAcc	gene expression	Rbm4	0.04	0.03	7.2e-06	0.02	0.02	0.01	0.02	7.3e-04	1.2e-04	2.2e-03	6.8e-04
7	pVTA	gene expression	Rbm4	0.07	0.05	1.3e-04	0.01	0.04	0.03	0.02	4.4e-02	7.9e-04	1.6e-03	5.3e-03
8	BLA	gene expression	Rbm4	0.14	0.09	6.7e-06	0.05	0.08	0.05	0.08	1.1e-03	4.6e-05	1.2e-03	4.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	1.8	3.2	6.0	-0.5	0.1	-0.3	2.1	2.5	1.9	2.4	2.3
Area under the delay curve	0.5	0.7	1.3	0.5	-0.8	-1.0	0.6	0.7	1.1	1.0	0.8
BMI with tail	2.1	7.4	15.3	-1.8	1.1	0.7	3.9	3.4	2.5	3.4	3.2
BMI without tail	0.4	2.1	3.9	-1.2	0.7	0.8	2.0	1.5	1.4	1.9	1.6
Body weight	1.0	4.2	11.2	-3.3	2.9	2.8	1.9	1.0	-0.2	1.0	1.0
Weight adjusted by age	0.5	1.4	3.3	-1.8	1.8	1.7	0.3	-0.2	-1.1	-0.5	-0.2
Bone surface	2.8	5.5	10.7	-2.7	2.3	1.4	3.3	2.7	0.9	2.2	2.5
Bone volume	1.7	3.4	6.6	-1.4	1.1	0.3	2.4	2.6	1.3	2.2	2.3
Breakpoint value in progressive ratio session	1.0	1.9	5.0	-2.2	2.2	1.5	1.3	0.7	-0.6	0.2	0.6
Number of licking bursts	0.1	0.3	0.7	-0.8	0.8	0.3	0.8	0.5	-0.1	0.3	0.3
Context. condit. distance diff. score	0.8	1.0	2.7	1.7	-1.6	-1.2	-0.9	-0.2	0.7	0.1	-0.0
Locomotion velocity, session 1	0.4	0.4	1.1	0.0	-0.0	0.2	-0.6	-1.0	-0.6	-0.8	-1.1
Locomotion distance, session 1	0.7	0.9	1.7	-0.4	0.0	-0.2	1.2	1.2	1.1	1.3	0.9
Locomotion velocity, session 2	0.8	1.0	2.9	-1.7	1.5	1.5	0.8	0.2	-0.3	0.2	0.1
Locomotion distance, session 2	0.2	0.3	0.6	-0.7	0.4	0.3	0.4	0.6	0.6	0.8	0.4
Locomotion velocity, session 3	0.3	0.4	0.7	0.4	-0.6	-0.6	0.0	0.7	0.9	0.8	0.6
Locomotion distance, session 3	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.3	0.0	0.1	0.0	0.1
Stereotopy head waving bouts, day 3	0.8	1.0	2.2	1.3	-1.5	-1.2	-0.6	0.3	1.2	0.8	0.4
Stereotopy head waving duration, day 3	1.0	1.2	2.4	1.4	-1.5	-1.4	-0.1	0.6	1.3	0.9	0.6
Locomotion velocity, session 7	0.6	0.7	1.4	0.6	-0.8	-0.5	0.6	0.8	1.2	1.0	0.8
Locomotion distance, session 7	0.0	0.1	0.2	0.1	-0.3	0.2	0.0	-0.1	0.5	0.3	0.1
Stereotopy head waving bouts, day 7	0.9	1.1	2.3	0.2	-0.2	-0.6	1.1	1.5	1.1	1.3	1.4
Stereotopy head waving duration, day 7	1.3	1.6	3.1	-0.8	0.7	0.3	1.6	1.8	0.9	1.5	1.7
Locomotion velocity, session 8	0.5	0.7	1.2	-1.1	1.0	1.1	-0.4	-0.6	-0.8	-0.5	-0.6
Locomotion distance, session 8	0.2	0.3	0.6	0.7	-0.8	-0.8	-0.4	0.3	0.7	0.5	0.2
Degree of sensitization distance	0.2	0.2	0.5	0.1	-0.3	0.0	0.6	0.4	0.7	0.6	0.4
Degree of sensitization stereotypy	0.8	0.9	1.9	-0.8	0.8	0.4	1.4	1.3	0.4	0.9	1.1
Conditioned locomotion	1.2	1.4	3.5	-1.5	1.5	1.9	-0.1	-1.0	-1.2	-0.9	-0.7
Cocaine response after cond. corrected	0.4	0.5	1.4	1.2	-1.1	-0.8	-0.7	-0.5	0.2	-0.3	-0.2
Cocaine response after cond. not corrected	0.3	0.4	1.0	1.0	-1.0	-0.9	-0.3	-0.1	0.3	0.0	0.0
Cocaine response before conditioning	0.4	0.5	1.0	-1.0	1.0	0.2	1.0	0.9	-0.0	0.5	0.4
Saline control response	1.2	1.7	5.0	-2.2	2.0	1.6	1.1	0.4	-0.5	0.3	0.2
Bone: connectivity density	2.3	3.7	7.9	-1.6	1.2	0.7	2.8	2.3	1.4	2.2	2.2
Bone: cortical apparent density	0.3	0.5	0.7	-0.5	0.6	0.7	-0.4	-0.8	-0.9	-0.8	-0.8
Bone: cortical area	0.5	0.8	2.0	-1.3	1.4	1.1	-0.0	-0.1	-1.0	-0.5	-0.4
Bone: cortical porosity	0.3	0.3	0.8	-0.1	-0.1	-0.1	0.3	0.7	0.8	0.9	0.7
Bone: cortical porosity	0.2	0.2	0.4	-0.4	0.2	0.4	0.2	0.5	0.5	0.7	0.6
Bone: cortical thickness	3.6	6.0	10.1	-2.8	3.0	3.2	-1.0	-1.8	-2.8	-2.1	-2.0
Bone: cortical thickness	1.7	2.1	3.0	-1.1	1.1	1.7	-1.1	-1.7	-1.5	-1.5	-1.6
Bone: cortical tissue density	0.4	0.7	0.9	-0.7	0.7	0.9	-0.4	-0.9	-1.0	-0.9	-0.8
Condit. Reinf. active minus inactive responses	0.3	0.3	0.6	-0.6	0.5	0.1	0.7	0.8	0.3	0.6	0.6
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.6	-0.4	0.4	-0.1	0.8	0.7	0.2	0.5	0.5
Condit. Reinf. active responses	0.1	0.2	0.3	-0.5	0.4	0.0	0.5	0.6	0.2	0.4	0.5
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.2	0.2	0.2	0.2	0.2
Incentive salience index mean	0.3	0.4	0.7	-0.7	0.6	0.3	0.8	0.8	0.3	0.7	0.6
Condit. Reinf. lever presses	0.2	0.3	0.8	-0.9	0.9	0.6	0.6	0.4	-0.2	0.2	0.2
Condit. Reinf. active minus inactive responses	0.8	1.2	2.8	0.3	-0.3	-1.1	0.8	1.7	1.0	1.3	1.4
Condit. Reinf. active-inactive response ratio	0.7	1.1	2.6	0.8	-0.7	-1.6	0.6	1.4	0.9	1.0	1.1
Condit. Reinf. active responses	1.3	1.8	4.2	-0.1	-0.1	-0.7	1.2	2.1	1.4	1.8	1.8
Condit. Reinf. inactive responses	0.6	0.9	1.9	-0.5	0.1	0.4	0.9	1.1	1.1	1.4	1.2
Condit. Reinf. lever presses	1.1	1.5	3.0	-1.7	1.6	0.9	1.1	1.5	0.2	1.0	1.1
Condit. Reinf. lever reinforcers received	1.1	1.5	3.9	-0.4	0.3	-0.4	1.1	2.0	1.2	1.7	1.7
Conditioned reinforcement - actives	0.0	0.1	0.2	-0.2	0.4	-0.1	-0.3	-0.0	-0.5	-0.4	-0.2
Conditioned reinforcement - inactives	0.4	1.2	3.3	1.7	-1.4	-1.8	-0.4	0.6	0.7	0.4	0.5
Conditioned locomotion	2.7	4.1	10.6	3.2	-2.9	-3.0	-1.8	-0.3	0.8	-0.2	-0.5
Patch foraging indifference point 0 sec	0.1	0.4	0.6	0.4	-0.4	-0.8	0.6	0.8	0.7	0.7	0.4
Patch foraging indifference point AUC	0.8	1.8	4.7	-2.0	2.1	2.2	0.4	-0.2	-1.2	-0.5	-0.1
Delay disc. indifference point, 0s delay	1.0	1.1	2.5	1.3	-1.6	-1.2	-0.3	0.3	1.4	0.9	0.4
Delay disc. indifference point, 16s delay	0.9	1.2	2.3	1.0	-1.0	-1.5	0.8	1.1	1.2	1.0	1.1
Delay disc. indifference point, 2s delay	0.4	0.4	0.7	0.6	-0.7	-0.8	0.2	0.6	0.8	0.7	0.5
Delay disc. indifference point, 24s delay	0.2	0.2	0.7	0.3	-0.3	-0.2	-0.5	-0.8	-0.3	-0.5	-0.7
Delay disc. indifference point, 4s delay	0.4	0.4	0.9	0.7	-1.0	-0.8	-0.0	0.2	1.0	0.7	0.4
Delay disc. indifference point, 8s delay	0.2	0.3	0.6	0.5	-0.7	-0.8	0.1	0.2	0.8	0.6	0.4
Indifference point function ln k	1.9	5.8	13.9	3.7	-3.6	-3.3	-2.4	-0.9	1.0	-0.4	-1.0
Indifference point function log k	1.9	5.8	13.9	3.7	-3.6	-3.3	-2.4	-0.9	1.0	-0.4	-1.0
Patch foraging total patch changes 0 sec	0.0	0.0	0.2	0.2	-0.2	-0.4	-0.0	0.0	0.0	-0.0	-0.3
Patch foraging total patch changes 12 sec	1.8	2.4	6.2	-2.5	2.3	2.2	1.3	0.5	-0.5	0.3	0.5
Patch foraging total patch changes 18 sec	0.2	0.6	1.2	-0.9	0.7	0.8	1.1	0.6	0.2	0.6	0.7
Patch foraging total patch changes 24 sec	0.4	1.3	3.0	-1.7	1.7	1.6	0.1	-0.4	-1.1	-0.6	-0.4
Patch foraging total patch changes 6 sec	0.6	0.9	2.0	-1.4	1.2	1.2	1.1	0.7	0.1	0.6	0.6
Patch foraging time to switch 0 sec	0.9	3.5	8.3	-1.6	1.2	0.7	2.9	2.2	1.2	2.0	2.2
Patch foraging water rate 0 sec	1.2	4.4	9.0	2.4	-1.9	-1.7	-3.0	-2.0	-1.0	-2.0	-2.2
Patch foraging water rate 12 sec	2.0	8.2	14.4	3.8	-3.4	-2.7	-3.8	-2.6	-0.4	-2.0	-2.6
Patch foraging water rate 18 sec	1.0	2.3	4.3	2.1	-1.9	-1.7	-1.8	-1.3	-0.1	-0.9	-1.4
Patch foraging water rate 24 sec	2.7	3.8	5.9	2.4	-2.1	-1.7	-2.4	-2.0	-0.7	-1.7	-2.1
Patch foraging water rate 6 sec	3.2	4.8	10.6	2.4	-2.0	-1.6	-3.3	-2.3	-0.8	-1.9	-2.3
Seeking ratio, delayed vs. immediate footshock	0.6	0.9	1.5	0.4	-0.6	-0.9	0.8	1.1	1.2	1.2	1.0
Distance traveled before self-admin	0.3	0.6	1.3	-0.6	0.5	-0.1	1.1	1.1	0.5	0.8	0.9
Distance traveled after self-admin	0.1	0.2	0.3	-0.5	0.5	0.2	0.4	0.6	-0.0	0.3	0.4
Extensor digitorum longus weight	3.4	13.6	34.9	-5.9	5.7	5.6	1.2	-0.5	-2.8	-1.0	-0.7
Bone: elastic displacement	1.7	2.2	4.4	0.5	-0.2	0.3	-1.8	-2.1	-1.4	-1.9	-1.9
Bone: elastic work	1.9	2.5	3.7	-1.4	1.5	1.9	-0.8	-1.7	-1.8	-1.7	-1.6
Bone: endosteal estimation	1.5	3.5	5.7	1.8	-2.0	-2.4	0.9	1.8	2.2	1.9	1.7
Bone: endosteal perimeter	2.4	6.0	10.1	1.9	-2.0	-3.2	1.6	2.8	2.7	2.5	2.5
Epididymis fat weight	1.0	5.2	14.0	3.7	-3.4	-3.5	-1.1	0.4	1.4	0.3	0.2
Delta time in closed arm before/after self-admin	0.6	0.6	1.3	-0.5	0.3	1.1	-0.8	-1.1	-0.5	-0.6	-0.8
Delta time in open arm before/after self-admin	0.2	0.3	0.5	-0.6	0.7	0.4	0.7	0.5	-0.2	0.1	0.4
Diff in mean of infusions in LGA sessions	0.3	0.6	1.3	-1.1	1.2	1.1	0.5	-0.2	-0.7	-0.3	-0.1
Delay discount exponential model param	0.4	0.5	0.9	-0.4	0.6	0.9	-0.5	-0.6	-0.9	-0.9	-0.7
Extinction: sum of active levers before priming	1.1	1.7	3.4	-1.7	1.6	1.0	1.8	1.2	0.1	0.9	1.2
Active lever presses in extinction session 6	1.8	1.8	4.7	-2.1	2.2	1.8	1.0	0.3	-1.0	-0.2	0.3
Bone: final force	0.8	1.2	3.7	-1.9	1.8	1.5	0.4	0.3	-0.6	0.0	0.1
Bone: final moment	0.7	1.1	3.3	-1.8	1.7	1.4	0.4	0.3	-0.6	0.1	0.1
Food consumed during 24 hour testing period	0.1	0.3	0.6	-0.3	0.5	0.2	-0.7	-0.3	-0.7	-0.6	-0.5
Glucose	2.8	4.4	6.8	2.4	-2.6	-2.6	0.6	1.7	2.6	2.0	1.5
Heart weight	2.1	3.3	6.3	1.7	-2.2	-1.7	1.2	1.4	2.5	2.0	1.5
Delay discount hyperbolic model param	0.4	0.5	1.0	-0.4	0.7	0.9	-0.4	-0.6	-1.0	-0.9	-0.7
Intermittent access intake day 1-15 change	0.1	0.4	1.2	1.1	-0.8	-1.0	-0.6	-0.2	-0.1	-0.4	-0.3
Intermittent access intake escalation	0.1	0.3	0.7	0.9	-0.5	-0.8	-0.5	-0.3	-0.3	-0.5	-0.4
Intermittent access intake escalation 2	0.2	0.4	0.9	0.9	-0.6	-0.8	-0.6	-0.3	-0.3	-0.6	-0.4
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	0.2	-0.0	-0.0	0.2	0.2	-0.0	0.0	0.2
Intermitt. access day 15 inactive lever presses	0.2	1.0	2.0	1.1	-1.0	-1.4	0.5	1.1	0.9	0.8	1.1
Intermitt. access escalation Index	0.8	2.7	6.6	2.5	-2.6	-2.2	-1.1	0.1	1.4	0.6	0.1
Intermittent access day 1 total infusions	1.8	5.5	8.4	2.1	-2.3	-2.6	1.3	2.3	2.9	2.5	2.3
Intermittent access day 15 total infusions	1.3	3.2	7.3	2.4	-2.3	-2.7	0.2	1.2	1.7	1.1	1.0
Intermittent access terminal intake (last 3 days)	2.0	3.5	6.7	2.2	-2.2	-2.6	0.7	1.7	2.0	1.6	1.5
Intermittent access total infusions	3.2	3.8	5.9	2.0	-2.1	-2.4	0.9	1.9	2.3	1.9	1.7
Intermittent access day 1 locomotion	1.8	3.3	5.0	1.7	-1.8	-2.0	1.1	1.8	2.2	1.9	1.8
Intermittent access day 15 total locomotion	0.8	3.3	6.9	2.2	-2.1	-2.6	0.5	1.6	1.8	1.4	1.4
Intermittent access total locomotion	5.2	6.3	11.9	2.8	-2.8	-3.4	0.8	2.3	2.7	2.2	2.0
Intermittent access standard deviation	0.1	0.5	1.3	1.1	-0.9	-0.9	-0.6	-0.3	0.1	-0.3	-0.3
Left kidney weight	0.2	2.0	4.9	2.2	-2.1	-1.8	-1.5	-0.2	0.8	0.0	-0.3
Right kidney weight	0.2	1.4	3.5	1.5	-1.3	-1.2	-1.9	-0.8	-0.2	-0.8	-1.0
Cocaine induced anxiety	0.0	0.1	0.1	-0.3	0.3	0.1	0.1	0.3	-0.1	0.1	0.3
Post-drug Anxiety	0.3	0.3	1.0	-0.9	1.0	0.8	-0.0	0.2	-0.5	-0.1	0.1
Baseline Anxiety	0.2	0.3	0.6	-0.5	0.4	0.6	-0.8	-0.6	-0.6	-0.5	-0.6
Tail length	0.6	3.0	3.9	-1.4	1.4	2.0	-1.6	-2.0	-1.9	-1.8	-1.7
Length with tail	1.3	5.7	11.3	-3.0	3.1	3.4	-0.8	-1.7	-2.5	-1.8	-1.5
Length without tail	0.8	4.3	9.0	-2.7	2.7	3.0	-0.5	-1.3	-2.1	-1.5	-1.4
Times rat made contact with spout	0.3	0.3	0.9	-0.6	0.4	0.5	0.9	0.3	0.3	0.5	0.5
Lifetime Intake	2.3	2.9	4.3	1.7	-1.8	-2.0	0.7	1.6	2.1	1.8	1.5
Liver weight, left	0.7	1.3	2.1	1.3	-1.2	-0.5	-1.4	-1.5	-0.3	-1.0	-1.3
Liver weight, right	1.1	2.0	4.4	2.1	-2.1	-1.5	-1.5	-1.1	0.4	-0.5	-1.0
Locomotor activity	1.4	2.2	4.1	1.6	-1.5	-1.0	-2.0	-1.7	-0.5	-1.3	-1.8
Locomotor testing distance	1.2	3.0	5.5	1.9	-1.8	-1.3	-2.3	-1.9	-0.4	-1.4	-2.0
Locomotor testing rearing	0.5	1.9	4.9	2.1	-2.2	-1.6	-1.2	-0.7	0.8	-0.1	-0.7
Locomotion in novel chamber	2.3	3.1	7.9	2.8	-2.7	-2.7	-0.9	0.1	1.1	0.3	-0.2
Locomotion in novel chamber post-restriction	0.6	1.7	4.5	2.1	-2.0	-1.9	-0.5	0.2	0.9	0.3	0.0
Fecal boli incidents, locomotor time 1	0.1	0.2	0.4	-0.2	0.4	0.5	0.6	0.3	-0.2	-0.0	0.5
Change in fecal boli incidents, locomotor task	0.1	0.2	0.4	0.3	-0.5	-0.6	0.1	0.1	0.6	0.4	0.0
Time >=10cm from walls, locomotor time 1	2.3	2.9	4.7	1.0	-1.0	-1.8	1.5	2.2	1.8	1.9	1.9
Bouts of movement, locomotor time 1	0.7	0.9	2.5	-1.5	1.6	1.1	1.0	0.2	-0.7	-0.1	0.3
Total resting periods, locomotor time 1	0.6	0.7	1.6	-1.2	1.3	0.7	1.1	0.5	-0.4	0.1	0.6
Rest time, locomotor task time 1	0.5	0.8	2.2	1.4	-1.1	-1.5	-0.9	-0.2	0.1	-0.3	-0.4
Distance moved, locomotor task time 1	0.3	0.7	1.5	-0.3	0.1	0.0	0.9	1.1	1.0	1.2	1.1
Vertical activity count, locomotor time 1	0.0	0.3	0.9	0.9	-0.9	-0.6	-0.5	-0.2	0.4	0.0	-0.1
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.3	-0.1	0.2	-0.4	0.4	0.5	0.0	0.2	0.3
Bouts of movement, locomotor time 2	0.1	0.4	1.1	-0.8	0.8	0.8	1.1	0.3	-0.0	0.3	0.5
Total resting periods, locomotor time 2	0.1	0.4	1.1	-0.5	0.4	0.5	1.0	0.5	0.2	0.5	0.7
Rest time, locomotor task time 2	0.8	1.3	3.4	1.8	-1.8	-1.5	-1.0	-0.2	0.7	0.0	-0.0
Distance moved, locomotor task time 2	0.6	0.7	2.2	-1.5	1.5	1.0	0.2	0.0	-0.8	-0.2	-0.1
Vertical activity count, locomotor time 2	0.7	1.7	2.8	-0.4	0.6	0.8	-1.4	-1.7	-1.5	-1.6	-1.6
Light reinforcement 1	0.0	0.2	0.4	0.5	-0.6	-0.6	-0.5	-0.3	0.1	-0.2	-0.2
Light reinforcement 2	0.2	0.4	1.8	1.0	-0.7	-1.3	-0.1	0.3	0.2	0.0	0.0
Bone: marrow area	1.5	3.8	6.1	1.9	-2.1	-2.5	0.9	1.8	2.3	1.9	1.8
Bone: maximum diameter	0.1	0.2	0.5	-0.4	0.6	-0.2	0.4	0.7	-0.2	0.2	0.4
Bone: maximum force	1.4	2.9	5.4	-2.3	2.1	1.2	2.1	1.8	0.2	1.3	1.5
Bone: maximum moment	1.4	2.6	4.8	-2.2	2.0	1.2	2.0	1.7	0.2	1.2	1.4
Mean time between licks in bursts	0.0	0.3	0.4	-0.4	0.3	0.6	-0.4	-0.7	-0.5	-0.4	-0.7
Mean num. licks in bursts	0.1	0.2	0.6	0.7	-0.8	-0.3	-0.2	-0.2	0.5	0.2	0.1
Cd content in liver	0.7	0.8	1.9	1.2	-1.2	-1.4	0.4	0.5	0.8	0.5	0.5
Co content in liver	2.7	3.1	7.1	1.1	-0.9	-0.2	-2.7	-2.4	-1.2	-2.0	-2.1
Cu content in liver	0.1	0.2	0.4	0.1	-0.2	-0.3	0.2	0.5	0.6	0.6	0.5
Fe content in liver	0.3	0.4	0.5	-0.5	0.5	0.7	-0.3	-0.7	-0.7	-0.7	-0.7
K content in liver	0.3	0.2	0.4	-0.6	0.4	0.4	0.7	0.5	0.3	0.6	0.4
Mg content in liver	0.4	0.4	0.8	0.7	-0.8	-0.8	0.3	0.5	0.9	0.7	0.4
Mn content in liver	2.0	2.3	5.8	-2.4	2.4	1.9	1.3	0.7	-0.8	0.2	0.6
Na content in liver	0.6	0.7	1.6	-0.7	0.9	0.4	-0.4	-0.7	-1.3	-1.1	-0.9
Rb content in liver	1.2	1.4	3.5	1.7	-1.9	-1.4	-0.0	0.4	1.4	0.8	0.5
Se content in liver	0.3	0.3	0.7	0.3	-0.2	-0.5	0.5	0.9	0.5	0.6	0.7
Sr content in liver	2.0	1.7	3.4	-1.7	1.8	1.8	0.1	-0.7	-1.5	-1.0	-0.6
Zn content in liver	0.1	0.1	0.3	-0.5	0.4	0.6	0.1	-0.1	-0.1	0.0	-0.0
Bone: minimum diameter	2.4	4.6	6.5	1.4	-1.7	-2.2	1.7	2.5	2.5	2.4	2.4
Time in familiar zone, hab. session 1	0.5	0.5	0.9	0.5	-0.5	-0.8	0.6	0.9	0.8	0.8	0.8
Time in novel zone, hab. session 1	0.6	0.7	1.4	0.4	-0.4	0.1	-1.2	-1.2	-0.5	-0.9	-1.0
Total zone transitions, hab. session 1	0.3	0.4	1.2	-1.1	1.0	0.8	0.6	0.5	-0.1	0.3	0.2
Total locomotion distance, hab. session 1	0.2	0.3	0.8	0.7	-0.7	-0.9	0.2	0.4	0.6	0.4	0.3
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.2	-0.2	-0.4	0.3	0.3	0.3	0.3	0.2
Time in familiar zone, hab. session 2	0.4	0.4	1.0	-0.1	0.1	0.6	-0.5	-1.0	-0.6	-0.8	-0.7
Time in novel zone, hab. session 2	0.5	0.5	1.1	0.1	-0.2	-0.5	0.5	1.1	0.9	1.0	0.8
Total zone transitions, hab. session 2	3.0	3.9	8.2	-0.8	0.2	-0.1	2.9	2.4	2.0	2.5	2.4
Total locomotion distance, hab. session 2	1.5	2.0	3.1	0.5	-0.8	-1.1	1.6	1.6	1.7	1.7	1.6
Locomotion velocity, hab. session 2	1.7	2.3	3.3	0.6	-0.9	-1.3	1.7	1.7	1.8	1.8	1.7
Novel to familiar place preference ratio	0.8	1.1	2.7	-1.0	1.0	0.4	1.7	1.3	0.2	0.8	1.1
Novelty place preference	0.7	0.9	2.5	-0.6	0.6	0.0	1.6	1.3	0.4	0.9	1.2
Time in novel zone, NPP test	0.6	0.7	1.8	-0.4	0.4	-0.0	1.3	1.2	0.5	0.8	1.1
Total zone transitions, NPP test	0.7	1.0	2.2	-1.5	1.2	0.9	1.2	1.0	0.3	0.9	0.8
Total locomotion distance, NPP test	0.1	0.2	0.3	0.1	-0.2	-0.4	0.1	0.5	0.6	0.6	0.3
Locomotion velocity, NPP test	0.1	0.1	0.3	-0.1	-0.1	-0.4	0.2	0.5	0.5	0.5	0.3
Intraocular pressure	0.2	0.3	0.6	0.8	-0.4	-0.3	-0.7	-0.6	-0.6	-0.8	-0.4
Delta distance traveled before/after self-admin	0.3	0.4	0.8	0.2	-0.1	0.3	-0.9	-0.8	-0.5	-0.7	-0.7
Delta ambulatory time before/after self-admin	0.2	0.4	0.8	0.0	0.0	0.4	-0.9	-0.8	-0.6	-0.7	-0.7
Parametrial fat weight	1.8	4.3	10.4	3.2	-3.2	-2.9	-0.8	0.5	1.8	0.8	0.6
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.5	-0.4	-0.6	-0.4	-0.2	-0.0	-0.2	-0.2
Pavlov. Cond. magazine entry latency	0.8	1.0	2.2	-0.3	0.2	-0.2	1.3	1.5	0.9	1.3	1.3
Pavlov. Cond. change in total contacts	0.5	0.6	1.6	-0.3	0.4	-0.2	1.0	1.3	0.4	0.8	1.0
Pavlov. Cond. index score	0.1	0.1	0.2	-0.4	0.5	0.3	0.5	0.5	-0.0	0.2	0.3
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.2	0.2	0.1	0.5	0.5	0.2	0.4	0.4
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.2	0.1	0.2	0.1	0.2	0.2	0.3	0.2
Pavlov. Cond. magazine entry number	0.2	0.2	0.6	0.7	-0.8	-0.4	-0.4	-0.4	0.3	-0.0	-0.2
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.3	-0.2	-0.3	-0.5	-0.4	-0.3	-0.5	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	-0.6	0.6	0.3	0.6	0.6	0.0	0.4	0.4
Pavlov. Cond. response bias	0.1	0.1	0.4	-0.6	0.6	0.4	0.1	0.3	-0.3	-0.0	0.0
Pavlov. Cond. lever latency	0.3	0.4	1.1	1.0	-1.1	-0.8	0.2	-0.2	0.5	0.1	0.1
Pavlov. Cond. magazine entry latency	2.1	2.9	6.3	-2.5	2.3	1.7	1.8	1.6	0.1	1.2	1.5
Pavlov. Cond. change in total contacts	0.8	1.8	3.4	-1.6	1.6	0.7	1.4	1.8	0.3	1.2	1.5
Pavlov. Cond. index score	1.1	1.7	4.0	-2.0	1.9	1.2	1.1	1.3	-0.1	0.8	1.0
Pavlov. Cond. latency score	1.0	1.5	3.6	-1.9	1.8	1.2	1.0	1.2	-0.2	0.7	0.9
Pavlov. Cond. lever contacts	0.2	0.4	1.1	-1.0	1.0	0.7	0.1	0.4	-0.3	0.1	0.2
Pavlov. Cond. magazine entry number	3.3	4.3	10.3	3.2	-3.0	-2.2	-2.1	-1.7	0.3	-1.1	-1.4
Pavlov. Cond. intertrial magazine entries	0.3	0.7	1.9	1.4	-1.3	-1.3	-0.3	-0.2	0.3	-0.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	1.4	2.1	4.9	-2.2	2.1	1.4	1.2	1.4	-0.1	0.9	1.1
Pavlov. Cond. response bias	1.0	1.3	3.2	-1.8	1.7	1.1	0.8	1.2	-0.1	0.7	0.9
Time in closed arm before self-admin	0.5	1.0	1.7	0.7	-0.7	-1.3	0.8	1.2	1.0	1.0	1.0
Time in closed arm after self-admin	0.1	0.1	0.2	0.4	-0.4	-0.3	-0.1	0.0	0.3	0.1	0.1
Time in open arm before self-admin	0.8	1.0	2.6	0.4	-0.6	0.2	-1.4	-1.6	-0.4	-0.9	-1.4
Time in open arm after self-admin	0.2	0.2	0.3	-0.3	0.2	0.5	-0.3	-0.6	-0.4	-0.4	-0.5
Bone: periosteal estimation	0.2	0.4	0.9	0.2	-0.2	-0.7	0.5	0.9	0.6	0.7	0.8
Bone: periosteal perimeter	0.5	1.0	2.6	-0.2	0.2	-0.7	1.1	1.6	0.8	1.2	1.3
Bone: post-yield work	6.6	11.3	21.0	-0.3	-0.1	-1.5	4.6	4.6	3.3	4.1	4.3
Progressive ratio test 1 active lever presses	0.2	0.3	0.4	0.2	-0.3	-0.5	0.4	0.7	0.6	0.6	0.6
Progressive ratio test 1 breakpoint	0.1	0.2	0.5	0.2	-0.2	-0.5	0.5	0.7	0.6	0.6	0.6
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.2	0.1	-0.1	-0.2	0.5	0.5	0.3	0.4	0.5
Progressive ratio test 2 active lever presses	1.1	1.5	3.2	1.4	-1.4	-1.8	0.3	1.2	1.3	1.1	1.0
Progressive ratio test 2 breakpoint	1.1	1.4	3.0	1.3	-1.3	-1.7	0.3	1.1	1.2	1.0	0.9
Progressive ratio test 2 inactive lever presses	1.6	5.0	11.3	3.2	-3.1	-3.4	-0.2	1.3	2.1	1.3	1.1
Incentive Sensitization - Responses	0.3	0.8	1.7	-0.0	-0.1	-0.5	1.1	1.3	0.9	1.1	1.2
Incentive Sensitization - Breakpoint	0.4	0.8	1.6	0.2	-0.2	-0.6	1.0	1.3	0.9	1.1	1.1
Sum of active levers in priming session hrs 5-6	2.7	2.6	5.3	-1.7	2.2	1.6	-0.6	-0.8	-2.3	-1.7	-0.9
Progressive ratio	1.1	3.1	6.2	-0.7	0.2	0.1	2.5	2.2	1.8	2.3	2.2
Food seeking constrained by brief footshock	0.1	0.1	0.4	-0.5	0.4	0.6	-0.0	-0.3	-0.3	-0.2	-0.3
Seeking ratio, punishment vs. effort	1.1	2.5	5.2	1.0	-0.7	-0.5	-2.3	-2.0	-1.2	-1.8	-2.0
Retroperitoneal fat weight	4.3	19.3	49.9	7.1	-6.8	-6.5	-2.6	-0.0	2.9	0.7	-0.1
Reaction time number correct	0.2	0.8	1.3	-0.6	0.8	0.8	-0.8	-0.9	-1.1	-1.0	-0.9
Reaction time mean minus median	0.4	2.5	6.0	-2.5	2.4	1.8	1.8	0.8	-0.7	0.3	0.7
Reaction time mean minus median AUC	0.2	1.6	3.9	-1.9	2.0	1.7	0.9	-0.2	-1.1	-0.5	-0.1
Reaction time num false alarms	0.8	1.3	3.1	0.4	-0.4	0.3	-1.8	-1.6	-0.9	-1.3	-1.4
Reaction time num false alarms AUC	0.5	1.1	2.2	-0.3	0.3	0.8	-1.3	-1.5	-1.0	-1.2	-1.3
Reaction time trials correct on left	0.2	0.8	1.3	-0.6	0.8	0.8	-0.8	-0.9	-1.1	-1.0	-0.9
Reaction time trials on left	0.3	1.0	1.6	-0.8	0.9	1.0	-0.8	-0.9	-1.3	-1.1	-0.9
Reaction time mean	0.0	0.1	0.3	-0.3	0.3	-0.0	0.5	0.4	0.1	0.3	0.3
Reaction time mean AUC	0.1	0.2	0.6	-0.2	0.2	-0.2	0.8	0.6	0.2	0.4	0.5
Median of all reaction times	0.1	0.2	0.4	0.4	-0.4	-0.6	0.3	0.4	0.5	0.5	0.4
Reaction time omissions	0.9	1.5	3.8	-2.0	1.9	1.8	0.7	-0.0	-0.9	-0.2	0.0
Reaction time false alarm rate	0.3	0.4	1.1	0.3	-0.3	0.2	-1.0	-1.0	-0.4	-0.7	-0.8
Reaction time premature initiation rate	1.0	1.5	3.2	-1.8	1.6	1.7	0.1	-0.9	-1.1	-0.7	-1.0
Reaction time premature initiations	1.1	3.4	5.9	-2.4	2.3	2.4	-0.3	-1.4	-1.9	-1.4	-1.5
Std. dev. reaction times	0.2	0.7	1.8	-1.3	1.3	1.0	1.0	0.4	-0.3	0.2	0.4
Reaction time trials completed	0.3	1.0	1.6	-0.8	0.9	1.0	-0.8	-0.9	-1.3	-1.1	-0.9
Reaction time trials AUC	0.2	0.8	1.2	-0.5	0.7	0.8	-0.9	-0.9	-1.1	-1.0	-0.9
Run reversals in cocaine runway, females	0.2	0.2	0.5	-0.3	0.0	0.3	0.5	0.3	0.6	0.7	0.5
Run reversals in cocaine runway, males	2.2	2.4	4.3	0.1	0.2	0.6	-2.1	-2.0	-1.7	-2.0	-1.9
Latency to leave start box in cocaine runway	0.9	1.2	2.2	0.2	-0.4	-0.6	1.5	1.4	1.2	1.3	1.2
Latency to leave start box in cocaine runway, F	0.5	0.6	1.2	0.2	-0.4	-0.4	1.1	1.0	1.0	1.0	0.7
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	-0.3	0.3	-0.0	0.7	0.7	0.3	0.5	0.6
Std. dev. time between licks in bursts	0.8	1.4	3.2	0.1	-0.2	0.6	-1.8	-1.8	-0.9	-1.3	-1.6
Total sessions with >9 infusions	0.8	1.0	1.9	0.0	-0.2	-0.3	1.1	1.3	1.2	1.4	1.3
Short access day 1 total inactive lever presses	0.7	1.3	3.4	1.9	-1.9	-1.5	-0.6	0.2	1.0	0.4	0.1
Short access day 10 total inactive lever presses	0.0	0.1	0.2	0.5	-0.5	-0.2	-0.2	-0.2	0.1	-0.1	-0.1
Short access day 1 total infusions	0.9	1.9	2.9	1.6	-1.7	-1.6	0.3	1.1	1.7	1.3	1.0
Short access day 10 total infusions	2.6	4.3	7.2	0.6	-1.0	-1.3	2.1	2.6	2.5	2.7	2.5
Short access total infusions	1.2	1.7	3.1	0.7	-0.9	-0.9	0.9	1.5	1.8	1.7	1.5
Short access day 1 locomotion	0.9	1.5	2.2	1.1	-1.2	-1.4	0.8	1.2	1.5	1.3	1.2
Short access day 10 total locomotion	0.4	1.7	2.4	1.1	-1.1	-1.4	1.0	1.5	1.5	1.4	1.4
Short access total locomotion	1.3	1.9	2.7	1.2	-1.3	-1.6	0.9	1.4	1.6	1.5	1.4
One hour access (0.3 mA shock)	2.6	3.1	7.2	2.6	-2.6	-2.7	-0.3	0.7	1.6	0.9	0.7
Compulsive drug intake	1.9	2.8	3.9	-1.4	1.4	1.9	-1.3	-2.0	-1.7	-1.7	-1.8
One hour access (shock baseline)	1.7	4.3	9.8	2.9	-2.7	-3.1	0.2	1.5	1.9	1.3	1.3
Social response proportion	0.6	0.8	2.2	-0.9	0.8	0.2	1.5	1.0	0.2	0.7	1.0
Social responses	0.1	0.2	0.4	-0.6	0.6	0.5	0.2	-0.2	-0.4	-0.2	-0.2
Social time	0.2	0.3	0.5	-0.7	0.7	0.7	-0.1	-0.5	-0.6	-0.5	-0.5
Soleus weight	2.0	5.8	14.5	3.8	-3.6	-3.0	-2.4	-1.4	0.6	-0.8	-1.3
Bone: stiffness	1.5	2.7	4.8	-1.8	1.5	0.7	2.2	2.1	0.7	1.6	1.8
Tibialis anterior weight	6.0	20.7	44.6	-6.6	6.7	6.6	0.0	-1.9	-4.5	-2.6	-2.1
Time to tail flick, vehicle, before self-admin	0.2	0.3	0.8	-0.3	0.1	0.1	0.9	0.6	0.5	0.6	0.6
Time to tail flick, vehicle, after self-admin	0.5	0.9	2.0	-0.4	0.1	0.1	1.4	1.1	1.1	1.3	1.1
Time to tail flick, test, before self-admin	1.7	2.0	3.3	1.5	-1.8	-1.8	0.2	1.0	1.8	1.4	0.9
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.2	0.4	0.0	0.4	0.3	-0.1	0.1	0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.8	-0.5	0.3	0.2	0.9	0.7	0.6	0.8	0.7
Delta time to tail flick, test, before/after SA	2.6	3.2	5.9	-1.7	2.1	2.0	-0.6	-1.5	-2.4	-2.0	-1.5
Tibia length	0.7	1.8	4.7	-1.9	2.2	1.4	-0.0	-0.3	-1.6	-0.9	-0.6
Ambulatory time before self-admin	0.4	1.1	2.6	-0.6	0.5	-0.2	1.6	1.5	0.7	1.1	1.3
Ambulatory time after self-admin	0.6	1.0	2.0	0.5	-0.5	-1.0	0.9	1.4	1.0	1.1	1.3
Bone: tissue strength	0.2	0.2	0.5	-0.0	-0.0	-0.2	0.5	0.7	0.4	0.6	0.5
Total heroin consumption	2.0	2.4	6.6	-2.6	2.5	2.0	1.2	0.3	-1.0	-0.1	0.4
Bone: trabecular number	1.8	3.3	6.2	-0.9	0.5	0.0	2.3	2.5	1.7	2.3	2.4
Bone: trabecular spacing	0.5	0.7	1.5	0.8	-0.8	-0.2	-1.2	-1.2	-0.4	-0.9	-1.0
Bone: trabecular thickness	1.3	1.8	2.9	0.7	-0.8	-1.2	1.2	1.7	1.6	1.7	1.6
Bone: trabecular tissue density	1.5	2.6	5.5	2.4	-1.9	-2.0	-2.2	-1.0	-0.2	-1.0	-1.0
Water consumed over 24 hours	0.2	0.4	1.3	-1.1	1.0	0.9	0.6	0.1	-0.3	0.1	0.0
Number of responses in last shaping day	0.1	0.2	0.6	0.1	-0.1	0.4	-0.7	-0.6	-0.2	-0.4	-0.5