Rbm4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Rbm4	0.04	0.03	3.9e-05	0.04	0.04	0.03	0.04	1.1e-05	3.4e-05	7.2e-05	1.2e-05
2	Brain	intron excision ratio	chr1_202078683_202086011	0.03	0.02	6.4e-03	0	0	0	0	1.9e-01	2.2e-01	1.8e-01	2.8e-01
3	BLA	gene expression	Rbm4	0.1	0.07	7.2e-04	0.06	0.04	0.04	0.05	6.8e-04	2.3e-03	2.9e-03	1.1e-03
4	PL	gene expression	Rbm4	0.05	0.04	9.2e-04	0.02	0.03	0.03	0.03	5.0e-03	8.2e-04	8.5e-04	8.0e-04
5	Brain	gene expression	Rbm4	0.15	0.08	3.9e-07	0.04	0.08	0.08	0.05	5.0e-05	1.3e-07	7.8e-08	2.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	2.2	3.8	6.9	-1.4	0.5	-2.6	2.3	-2.1
Area under the delay curve	0.7	0.7	2.0	-0.7	1.4	-0.6	0.8	-0.4
BMI with tail	1.4	4.5	13.0	-0.3	-0.2	-3.6	2.3	-2.0
BMI without tail	0.4	0.8	2.8	0.0	-0.2	-1.7	0.9	-0.5
Body weight	0.7	3.0	5.3	2.2	-2.3	-2.2	-0.2	0.1
Weight adjusted by age	0.6	0.7	2.1	1.4	-0.9	-0.3	-0.6	0.2
Bone surface	2.6	4.6	11.5	-0.2	-1.3	-3.4	2.0	-2.5
Bone volume	2.4	4.0	8.7	-0.9	-0.5	-2.9	2.2	-2.4
Breakpoint value in progressive ratio session	1.0	1.1	2.8	1.2	-1.7	-1.1	-0.2	-0.3
Number of licking bursts	0.1	0.1	0.4	0.0	-0.2	-0.6	0.2	-0.3
Context. condit. distance diff. score	0.6	0.7	1.8	-1.0	1.4	0.7	0.3	-0.1
Locomotion velocity, session 1	0.7	0.7	1.0	0.6	0.5	1.0	-1.0	1.0
Locomotion distance, session 1	0.6	0.8	1.5	-0.6	0.9	-1.2	0.8	-0.8
Locomotion velocity, session 2	0.5	0.6	1.0	1.0	-0.9	-0.9	-0.1	0.1
Locomotion distance, session 2	0.2	0.2	0.9	0.3	0.3	-1.0	0.3	-0.2
Locomotion velocity, session 3	0.3	0.4	0.5	-0.6	0.7	-0.5	0.7	-0.6
Locomotion distance, session 3	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1	0.0
Stereotopy head waving bouts, day 3	0.5	0.6	1.7	-0.9	1.3	-0.1	0.8	-0.3
Stereotopy head waving duration, day 3	0.7	0.9	1.9	-1.1	1.4	-0.1	0.9	-0.6
Locomotion velocity, session 7	0.8	0.8	1.2	-1.1	0.7	-0.6	1.0	-1.1
Locomotion distance, session 7	0.0	0.0	0.0	-0.1	0.2	0.1	-0.1	-0.1
Stereotopy head waving bouts, day 7	1.4	1.5	2.6	-1.2	0.2	-1.2	1.6	-1.4
Stereotopy head waving duration, day 7	1.8	2.2	4.8	-0.5	-0.7	-2.2	1.8	-1.6
Locomotion velocity, session 8	0.5	0.6	1.4	1.2	-0.6	0.2	-0.9	0.8
Locomotion distance, session 8	0.3	0.4	1.2	-0.6	1.1	-0.0	0.4	-0.4
Degree of sensitization distance	0.1	0.1	0.1	-0.1	0.4	-0.2	0.2	-0.4
Degree of sensitization stereotypy	1.3	1.5	2.5	-0.5	-1.1	-1.6	1.3	-1.3
Conditioned locomotion	1.7	1.9	3.2	1.8	-1.7	0.3	-1.4	1.2
Cocaine response after cond. corrected	0.4	0.4	0.7	-0.7	0.8	0.8	-0.3	0.4
Cocaine response after cond. not corrected	0.4	0.4	1.1	-0.8	1.1	0.4	0.1	0.1
Cocaine response before conditioning	0.4	0.4	1.2	0.2	-0.2	-1.1	0.6	-0.7
Saline control response	0.6	0.8	2.1	1.5	-0.8	-1.1	-0.1	0.3
Bone: connectivity density	2.3	3.7	8.7	-0.8	-0.5	-2.9	2.0	-2.2
Bone: cortical apparent density	0.2	0.3	0.5	0.4	-0.7	0.2	-0.6	0.7
Bone: cortical area	0.6	0.9	2.1	1.3	-1.5	0.0	-0.6	0.4
Bone: cortical porosity	0.4	0.5	0.9	-0.4	0.5	-0.9	0.9	-0.5
Bone: cortical porosity	0.2	0.2	0.7	0.1	0.0	-0.8	0.6	-0.2
Bone: cortical thickness	3.6	5.9	9.7	3.1	-3.0	0.9	-2.3	2.2
Bone: cortical thickness	2.7	3.1	3.9	2.0	-1.5	1.3	-1.9	2.0
Bone: cortical tissue density	0.3	0.4	0.6	0.5	-0.8	0.2	-0.7	0.8
Condit. Reinf. active minus inactive responses	0.2	0.3	0.6	0.0	0.5	-0.8	0.4	-0.5
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.2	0.5	-0.6	0.4	-0.6
Condit. Reinf. active responses	0.1	0.1	0.3	0.1	0.3	-0.5	0.2	-0.5
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.1	-0.0	-0.2	0.2	-0.4
Incentive salience index mean	0.2	0.3	0.8	0.1	0.4	-0.9	0.4	-0.5
Condit. Reinf. lever presses	0.1	0.1	0.2	0.4	-0.4	-0.5	-0.1	-0.2
Condit. Reinf. active minus inactive responses	1.3	1.6	2.1	-1.4	0.8	-1.1	1.5	-1.5
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.0	-1.3	0.9	-0.6	1.3	-1.4
Condit. Reinf. active responses	1.7	2.4	3.3	-1.4	0.8	-1.8	1.8	-1.7
Condit. Reinf. inactive responses	0.9	1.1	2.6	-0.6	0.2	-1.6	1.2	-0.9
Condit. Reinf. lever presses	1.1	1.5	4.0	0.4	-1.2	-2.0	1.0	-1.0
Condit. Reinf. lever reinforcers received	1.5	2.1	3.7	-1.1	0.4	-1.9	1.7	-1.6
Conditioned reinforcement - actives	0.0	0.0	0.1	-0.2	-0.3	0.1	-0.1	-0.3
Conditioned reinforcement - inactives	1.5	1.7	4.0	-2.0	1.5	0.7	0.9	-1.1
Conditioned locomotion	1.7	2.0	4.8	-1.5	1.7	2.2	-0.2	0.2
Patch foraging indifference point 0 sec	0.3	0.5	1.0	-1.0	0.3	-0.5	0.7	-0.9
Patch foraging indifference point AUC	1.3	1.5	4.5	1.5	-2.1	-0.7	-0.4	0.2
Delay disc. indifference point, 0s delay	1.0	1.1	4.3	-0.8	2.1	0.2	0.5	0.2
Delay disc. indifference point, 16s delay	1.7	1.7	2.1	-1.5	1.3	-1.0	1.4	-1.4
Delay disc. indifference point, 2s delay	0.2	0.2	0.6	-0.4	0.8	0.0	0.3	-0.1
Delay disc. indifference point, 24s delay	0.3	0.3	0.5	0.3	0.4	0.5	-0.6	0.7
Delay disc. indifference point, 4s delay	0.3	0.4	1.4	-0.5	1.2	-0.1	0.3	0.2
Delay disc. indifference point, 8s delay	0.3	0.3	1.3	-0.3	1.2	-0.0	0.4	0.3
Indifference point function ln k	2.7	3.7	9.8	-1.7	3.1	2.3	-0.3	0.8
Indifference point function log k	2.7	3.7	9.8	-1.7	3.1	2.3	-0.3	0.8
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	-0.3	0.1	0.1	0.0	-0.1
Patch foraging total patch changes 12 sec	1.2	1.6	4.0	1.1	-2.0	-1.6	0.2	-0.5
Patch foraging total patch changes 18 sec	0.6	0.8	1.2	-0.4	-1.1	-1.1	0.9	-1.0
Patch foraging total patch changes 24 sec	0.6	0.7	1.7	1.2	-1.3	-0.3	-0.6	0.4
Patch foraging total patch changes 6 sec	0.4	0.6	1.7	0.4	-0.8	-1.3	0.6	-0.4
Patch foraging time to switch 0 sec	1.7	2.6	7.3	0.1	-0.7	-2.7	1.5	-1.7
Patch foraging water rate 0 sec	1.8	2.8	8.9	-1.0	1.1	3.0	-1.2	1.2
Patch foraging water rate 12 sec	3.8	5.8	15.2	-1.0	2.4	3.9	-1.6	2.0
Patch foraging water rate 18 sec	1.5	2.0	3.8	-0.6	1.9	2.0	-0.6	1.3
Patch foraging water rate 24 sec	2.1	2.9	8.2	-0.9	1.4	2.9	-1.3	1.4
Patch foraging water rate 6 sec	2.3	3.4	7.9	-0.4	1.6	2.8	-1.6	1.9
Seeking ratio, delayed vs. immediate footshock	0.6	0.6	1.2	-0.5	1.1	-0.9	0.8	-0.6
Distance traveled before self-admin	0.1	0.1	0.3	0.2	-0.6	-0.5	0.1	-0.3
Distance traveled after self-admin	0.1	0.1	0.3	0.0	-0.5	-0.3	0.2	-0.6
Extensor digitorum longus weight	2.2	8.6	19.1	4.0	-4.4	-1.9	-1.5	1.2
Bone: elastic displacement	2.2	2.5	4.8	0.7	-0.1	2.2	-1.7	2.0
Bone: elastic work	2.3	3.0	4.3	1.9	-1.4	1.3	-1.8	2.1
Bone: endosteal estimation	1.6	3.4	5.0	-2.0	2.2	-1.0	1.9	-1.8
Bone: endosteal perimeter	3.2	6.5	8.8	-2.6	2.7	-1.7	2.7	-3.0
Epididymis fat weight	1.3	3.1	8.4	-2.9	1.8	0.4	1.4	-1.2
Delta time in closed arm before/after self-admin	0.6	0.6	1.3	0.4	-0.4	0.8	-0.9	1.1
Delta time in open arm before/after self-admin	0.2	0.2	0.8	0.1	-0.9	-0.2	0.2	-0.5
Diff in mean of infusions in LGA sessions	0.4	0.4	1.9	0.3	-1.4	-0.3	-0.5	-0.0
Delay discount exponential model param	0.5	0.5	1.7	0.5	-1.3	0.4	-0.6	0.3
Extinction: sum of active levers before priming	1.4	1.4	3.3	0.7	-1.6	-1.8	0.3	-0.7
Active lever presses in extinction session 6	1.6	1.5	4.2	1.5	-2.1	0.1	-1.1	0.4
Bone: final force	0.6	0.9	1.9	1.4	-1.3	-1.0	-0.2	0.1
Bone: final moment	0.5	0.8	1.6	1.3	-1.2	-1.0	-0.1	0.0
Food consumed during 24 hour testing period	0.1	0.1	0.3	0.6	-0.2	-0.1	-0.3	0.2
Glucose	2.2	3.3	5.2	-2.3	2.1	-0.8	2.0	-1.6
Heart weight	1.2	1.7	4.7	-2.2	1.4	0.4	1.1	-0.7
Delay discount hyperbolic model param	0.4	0.4	1.5	0.5	-1.2	0.4	-0.6	0.2
Intermittent access intake day 1-15 change	0.1	0.1	0.1	0.0	-0.2	0.3	-0.3	0.2
Intermittent access intake escalation	0.0	0.0	0.1	-0.2	0.1	0.3	-0.1	-0.1
Intermittent access intake escalation 2	0.3	0.2	0.5	0.3	-0.4	0.7	-0.6	0.3
Intermitt. access day 1 inactive lever presses	0.7	0.7	1.8	-1.3	0.2	-0.1	1.0	-0.9
Intermitt. access day 15 inactive lever presses	0.7	0.8	1.5	-1.2	0.3	-0.3	1.0	-1.2
Intermitt. access escalation Index	2.2	1.9	5.3	-1.7	2.3	0.6	1.0	-0.2
Intermittent access day 1 total infusions	5.5	6.4	11.2	-3.3	2.5	-1.1	2.7	-2.4
Intermittent access day 15 total infusions	3.3	3.7	8.1	-2.8	2.1	-0.1	1.8	-1.7
Intermittent access terminal intake (last 3 days)	3.1	3.4	7.2	-2.7	1.5	-0.6	1.9	-1.9
Intermittent access total infusions	4.1	4.6	8.2	-2.9	1.8	-1.1	2.3	-2.2
Intermittent access day 1 locomotion	3.9	4.1	7.0	-2.6	1.9	-0.9	2.3	-2.0
Intermittent access day 15 total locomotion	2.6	2.8	5.6	-2.4	1.7	-0.4	1.6	-1.6
Intermittent access total locomotion	5.9	6.8	11.6	-3.4	2.5	-1.1	2.8	-2.6
Intermittent access standard deviation	0.1	0.1	0.3	-0.4	0.1	0.6	-0.1	0.0
Left kidney weight	0.1	0.4	1.5	-0.6	0.3	1.2	-0.1	0.2
Right kidney weight	0.1	0.4	0.7	-0.6	-0.7	0.8	-0.4	-0.2
Cocaine induced anxiety	0.0	0.1	0.1	0.2	-0.3	0.2	-0.3	-0.1
Post-drug Anxiety	1.0	1.1	2.8	1.3	-1.7	0.0	-0.9	0.3
Baseline Anxiety	1.2	1.3	2.7	1.5	-1.6	-0.1	-0.9	0.7
Tail length	1.6	4.8	6.7	2.4	-1.5	1.7	-2.6	2.5
Length with tail	1.4	5.2	9.2	3.0	-2.9	0.2	-2.1	1.9
Length without tail	0.7	1.5	3.5	1.7	-1.9	-0.8	-0.6	0.3
Times rat made contact with spout	0.2	0.2	0.7	0.2	0.2	-0.9	0.2	-0.3
Lifetime Intake	3.7	4.2	7.6	-2.8	1.8	-1.1	2.2	-2.0
Liver weight, left	0.1	0.2	0.4	0.3	0.2	0.7	-0.4	0.6
Liver weight, right	0.2	0.4	0.7	0.3	0.6	0.8	-0.6	0.8
Locomotor activity	1.3	2.0	4.9	-0.5	1.4	2.2	-1.2	1.2
Locomotor testing distance	1.8	3.0	6.4	-0.5	2.0	2.5	-1.4	1.6
Locomotor testing rearing	0.8	1.2	3.3	-1.0	1.8	1.2	0.0	0.4
Locomotion in novel chamber	1.5	1.9	4.4	-1.8	2.1	1.0	0.7	-0.7
Locomotion in novel chamber post-restriction	0.6	0.8	1.7	-1.3	1.0	0.9	0.3	-0.3
Fecal boli incidents, locomotor time 1	0.6	0.7	1.5	-0.4	-1.2	-0.7	0.5	-1.0
Change in fecal boli incidents, locomotor task	0.4	0.4	2.0	0.0	1.4	-0.0	0.0	0.3
Time >=10cm from walls, locomotor time 1	3.8	3.9	5.5	-2.0	1.6	-1.5	2.2	-2.3
Bouts of movement, locomotor time 1	0.5	0.6	1.3	0.6	-1.1	-1.1	0.0	-0.2
Total resting periods, locomotor time 1	0.5	0.6	1.6	0.2	-1.0	-1.3	0.3	-0.6
Rest time, locomotor task time 1	0.3	0.3	0.9	-0.4	0.7	0.9	-0.4	0.3
Distance moved, locomotor task time 1	0.4	0.4	0.8	-0.3	0.4	-0.6	0.9	-0.8
Vertical activity count, locomotor time 1	0.3	0.3	0.6	-0.7	0.7	0.4	0.3	0.0
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.5	-0.4	0.3	-0.3	0.5	-0.7
Bouts of movement, locomotor time 2	0.2	0.2	0.5	0.3	-0.7	-0.7	0.1	-0.2
Total resting periods, locomotor time 2	0.2	0.2	0.5	0.0	-0.5	-0.7	0.3	-0.3
Rest time, locomotor task time 2	0.6	0.7	1.7	-1.0	1.3	0.6	0.4	-0.0
Distance moved, locomotor task time 2	0.3	0.3	1.0	1.0	-0.5	-0.1	-0.3	0.4
Vertical activity count, locomotor time 2	1.5	1.7	3.1	1.2	-0.3	1.3	-1.4	1.8
Light reinforcement 1	0.1	0.2	0.2	-0.4	0.5	0.5	-0.3	0.1
Light reinforcement 2	0.3	0.4	1.1	-1.1	0.5	0.1	0.4	-0.7
Bone: marrow area	1.6	3.5	5.2	-2.1	2.3	-1.0	1.9	-1.8
Bone: maximum diameter	0.1	0.1	0.3	0.2	-0.4	-0.4	0.2	-0.5
Bone: maximum force	1.2	2.1	6.0	0.4	-1.0	-2.4	1.1	-1.4
Bone: maximum moment	1.0	1.7	5.1	0.4	-0.9	-2.3	1.0	-1.3
Mean time between licks in bursts	0.5	0.7	1.0	1.0	0.4	0.5	-1.0	0.9
Mean num. licks in bursts	0.1	0.1	0.3	-0.2	0.6	0.0	0.2	-0.1
Cd content in liver	0.2	0.3	0.7	-0.7	0.3	0.8	-0.2	-0.0
Co content in liver	2.4	2.8	6.2	0.9	0.7	2.5	-1.7	1.9
Cu content in liver	0.1	0.1	0.2	0.5	-0.3	-0.5	0.4	0.0
Fe content in liver	0.1	0.1	0.4	0.4	-0.6	0.2	-0.3	-0.0
K content in liver	1.0	0.9	3.4	0.3	-0.4	-1.8	0.8	-0.7
Mg content in liver	2.7	2.8	4.9	-1.2	0.9	-2.2	1.9	-1.8
Mn content in liver	1.2	1.4	3.3	0.2	-1.8	-1.6	0.3	-1.1
Na content in liver	0.5	0.5	1.1	1.0	-0.8	0.2	-0.7	0.4
Rb content in liver	1.3	1.6	2.7	-1.5	1.6	-0.6	1.4	-0.9
Se content in liver	1.5	1.8	3.3	-1.0	-0.1	-1.4	1.6	-1.8
Sr content in liver	2.1	1.9	4.5	1.8	-2.1	0.2	-1.2	0.8
Zn content in liver	0.4	0.4	0.7	0.8	-0.8	-0.9	-0.0	0.0
Bone: minimum diameter	2.2	4.1	5.9	-2.1	1.7	-1.6	2.4	-2.1
Time in familiar zone, hab. session 1	0.8	0.7	1.1	-0.8	0.9	-0.6	0.7	-1.0
Time in novel zone, hab. session 1	1.0	0.9	1.7	0.7	0.2	1.3	-1.0	1.3
Total zone transitions, hab. session 1	0.1	0.1	0.4	0.4	-0.2	-0.6	-0.1	-0.3
Total locomotion distance, hab. session 1	0.2	0.2	0.8	-0.6	0.9	0.0	0.2	-0.1
Locomotion velocity, hab. session 1	0.0	0.1	0.2	-0.3	0.4	-0.2	0.1	-0.0
Time in familiar zone, hab. session 2	1.0	1.0	1.8	1.0	-0.1	1.0	-1.1	1.3
Time in novel zone, hab. session 2	1.1	1.1	1.7	-0.9	0.1	-1.1	1.2	-1.3
Total zone transitions, hab. session 2	2.5	3.3	6.8	-1.3	0.7	-2.6	1.9	-2.0
Total locomotion distance, hab. session 2	1.2	1.6	2.0	-1.4	1.2	-1.3	1.3	-1.1
Locomotion velocity, hab. session 2	1.4	1.9	2.7	-1.6	1.3	-1.3	1.4	-1.3
Novel to familiar place preference ratio	1.2	1.2	2.4	-0.2	-0.9	-1.5	1.0	-1.3
Novelty place preference	1.1	1.1	2.0	-0.5	-0.6	-1.4	1.1	-1.3
Time in novel zone, NPP test	0.9	0.9	1.6	-0.5	-0.5	-1.3	1.1	-1.2
Total zone transitions, NPP test	0.4	0.5	2.0	0.3	-0.1	-1.4	0.4	-0.6
Total locomotion distance, NPP test	0.1	0.2	0.6	-0.3	0.8	-0.4	0.3	-0.1
Locomotion velocity, NPP test	0.1	0.2	0.4	-0.3	0.6	-0.4	0.2	-0.1
Intraocular pressure	0.4	0.6	1.3	-1.0	-1.1	0.7	-0.3	-0.3
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.1	-0.2	0.3	-0.2	0.0
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	0.1	-0.1	0.4	-0.3	0.2
Parametrial fat weight	1.4	2.8	6.5	-2.5	1.4	-0.4	1.8	-1.4
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.1	0.4	0.5	-0.1	0.3
Pavlov. Cond. magazine entry latency	1.3	1.6	2.4	-1.2	0.3	-1.6	1.4	-1.5
Pavlov. Cond. change in total contacts	0.9	1.0	1.9	-0.9	-0.1	-1.2	1.0	-1.4
Pavlov. Cond. index score	0.1	0.2	0.3	-0.3	-0.3	-0.6	0.3	-0.6
Pavlov. Cond. latency score	0.1	0.2	0.4	-0.4	-0.1	-0.5	0.4	-0.6
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.1	-0.1	-0.2	0.0	-0.2
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	0.1	0.7	0.5	-0.2	0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.1	-0.0	0.5	-0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	-0.2	-0.4	-0.7	0.3	-0.6
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.2	-0.5	-0.4	0.2	-0.4
Pavlov. Cond. lever latency	0.4	0.5	1.1	-0.3	1.0	1.0	-0.6	0.5
Pavlov. Cond. magazine entry latency	1.2	1.4	4.3	0.7	-0.9	-2.1	0.6	-1.0
Pavlov. Cond. change in total contacts	1.7	2.4	5.9	0.0	-1.2	-2.4	1.4	-1.6
Pavlov. Cond. index score	1.1	1.5	4.0	0.7	-1.2	-2.0	0.8	-0.9
Pavlov. Cond. latency score	0.9	1.2	3.2	0.7	-1.0	-1.8	0.7	-0.9
Pavlov. Cond. lever contacts	0.3	0.4	1.1	0.7	-1.0	-0.6	0.1	-0.0
Pavlov. Cond. magazine entry number	2.0	2.4	7.1	-1.1	1.5	2.7	-0.7	1.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.9	-1.0	0.7	0.8	0.1	-0.0
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	4.3	0.8	-1.3	-2.1	0.7	-0.9
Pavlov. Cond. response bias	0.7	1.0	2.3	0.7	-1.2	-1.5	0.5	-0.7
Time in closed arm before self-admin	0.3	0.4	0.6	-0.6	0.2	-0.7	0.5	-0.8
Time in closed arm after self-admin	0.1	0.1	0.4	-0.6	0.1	-0.0	-0.1	-0.1
Time in open arm before self-admin	0.7	0.8	1.6	0.3	1.0	1.0	-0.6	1.3
Time in open arm after self-admin	0.4	0.4	0.8	0.5	-0.4	0.9	-0.6	0.7
Bone: periosteal estimation	0.2	0.3	0.7	-0.3	0.2	-0.5	0.7	-0.8
Bone: periosteal perimeter	0.5	0.9	1.7	-0.4	0.2	-1.1	1.0	-1.3
Bone: post-yield work	9.6	13.1	20.8	-2.9	1.3	-4.3	4.0	-4.6
Progressive ratio test 1 active lever presses	1.0	1.0	2.5	-1.6	1.1	0.2	0.8	-0.8
Progressive ratio test 1 breakpoint	0.7	0.7	1.9	-1.4	0.9	0.3	0.6	-0.6
Progressive ratio test 1 inactive lever presses	0.6	0.6	1.2	-1.1	0.9	-0.1	0.8	-0.6
Progressive ratio test 2 active lever presses	1.9	2.0	4.3	-2.1	1.4	-0.3	1.3	-1.4
Progressive ratio test 2 breakpoint	1.3	1.5	3.6	-1.9	1.4	0.3	0.9	-0.9
Progressive ratio test 2 inactive lever presses	4.2	4.8	9.7	-3.1	2.7	-0.1	1.9	-1.9
Incentive Sensitization - Responses	0.7	0.7	1.1	-1.0	0.2	-0.8	0.9	-1.0
Incentive Sensitization - Breakpoint	0.7	0.7	1.1	-1.0	0.3	-0.7	0.9	-1.0
Sum of active levers in priming session hrs 5-6	1.4	1.4	4.3	1.0	-2.1	0.3	-1.2	0.2
Progressive ratio	1.9	2.3	5.6	-0.6	-0.1	-2.4	1.7	-1.6
Food seeking constrained by brief footshock	0.3	0.4	0.7	0.8	-0.1	0.2	-0.6	0.9
Seeking ratio, punishment vs. effort	2.1	2.6	5.3	0.6	0.8	2.3	-1.7	1.9
Retroperitoneal fat weight	2.0	6.7	15.7	-4.0	3.3	0.9	2.0	-1.4
Reaction time number correct	0.4	0.6	1.1	0.6	-1.0	0.5	-0.9	0.5
Reaction time mean minus median	1.2	1.6	4.0	0.5	-2.0	-1.7	0.3	-0.9
Reaction time mean minus median AUC	0.8	1.0	3.8	0.8	-2.0	-0.6	-0.6	-0.0
Reaction time num false alarms	1.5	2.0	3.3	0.9	0.3	1.8	-1.7	1.8
Reaction time num false alarms AUC	1.4	1.9	3.2	1.2	-0.3	1.4	-1.7	1.8
Reaction time trials correct on left	0.4	0.6	1.1	0.6	-1.0	0.5	-0.9	0.5
Reaction time trials on left	0.5	0.7	1.4	0.7	-1.2	0.6	-1.0	0.6
Reaction time mean	0.1	0.1	0.2	-0.2	-0.2	-0.4	0.3	-0.5
Reaction time mean AUC	0.2	0.2	0.4	-0.4	-0.1	-0.6	0.5	-0.6
Median of all reaction times	0.1	0.1	0.2	-0.5	0.3	-0.2	0.4	-0.4
Reaction time omissions	0.6	0.8	2.9	0.8	-1.7	-0.4	-0.5	0.1
Reaction time false alarm rate	0.8	1.1	2.2	0.8	0.3	1.2	-1.2	1.5
Reaction time premature initiation rate	0.9	1.2	2.3	1.5	-0.9	0.3	-1.2	1.2
Reaction time premature initiations	1.8	2.6	4.4	2.1	-1.6	0.5	-1.8	1.5
Std. dev. reaction times	0.4	0.6	1.7	0.1	-1.3	-1.0	0.2	-0.6
Reaction time trials completed	0.5	0.7	1.4	0.7	-1.2	0.6	-1.0	0.6
Reaction time trials AUC	0.4	0.5	0.8	0.5	-0.9	0.6	-0.9	0.5
Run reversals in cocaine runway, females	0.4	0.4	1.0	-0.0	0.8	-1.0	0.6	-0.1
Run reversals in cocaine runway, males	2.8	2.7	4.5	1.3	-1.0	2.1	-1.8	1.8
Latency to leave start box in cocaine runway	0.9	1.0	1.5	-0.9	0.2	-1.1	1.2	-1.2
Latency to leave start box in cocaine runway, F	0.4	0.4	0.6	-0.6	0.2	-0.8	0.8	-0.7
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.1	-0.1	-0.2	0.3	-0.4
Std. dev. time between licks in bursts	1.7	2.1	3.4	1.1	-0.1	1.9	-1.5	1.8
Total sessions with >9 infusions	1.1	1.2	2.5	-1.6	1.0	-0.4	1.1	-0.9
Short access day 1 total inactive lever presses	1.5	1.6	3.8	-2.0	1.6	0.5	1.0	-0.8
Short access day 10 total inactive lever presses	0.4	0.5	1.0	-1.0	0.8	0.9	0.2	0.2
Short access day 1 total infusions	3.1	3.3	6.5	-2.5	1.6	-0.8	2.0	-1.6
Short access day 10 total infusions	5.1	5.7	7.7	-2.7	1.7	-2.0	2.8	-2.6
Short access total infusions	2.1	2.4	4.0	-2.0	1.2	-1.0	1.7	-1.5
Short access day 1 locomotion	2.9	3.2	4.6	-2.1	1.6	-1.2	2.0	-1.7
Short access day 10 total locomotion	2.4	2.6	3.8	-1.9	1.6	-0.9	1.9	-1.5
Short access total locomotion	2.1	2.2	3.2	-1.8	1.4	-0.9	1.7	-1.4
One hour access (0.3 mA shock)	2.6	3.1	7.2	-2.7	2.2	0.5	1.3	-1.1
Compulsive drug intake	2.4	2.5	4.6	2.1	-1.0	0.8	-1.7	1.7
One hour access (shock baseline)	3.3	3.8	9.1	-3.0	1.8	-0.1	1.9	-1.8
Social response proportion	0.6	0.7	2.0	0.2	-0.2	-1.4	0.8	-0.9
Social responses	0.2	0.2	0.6	0.8	-0.5	-0.2	-0.3	0.3
Social time	0.4	0.6	1.6	1.3	-0.2	0.0	-0.4	1.0
Soleus weight	1.1	3.1	7.4	-1.4	2.7	2.3	-0.2	0.9
Bone: stiffness	1.6	2.6	6.5	-0.1	-0.7	-2.5	1.5	-1.9
Tibialis anterior weight	4.9	16.8	34.5	5.9	-5.6	-0.8	-3.0	2.9
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.7	-0.2	0.1	-0.8	0.5	-0.6
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.8	0.6	-0.6	-0.9	0.2	0.3
Time to tail flick, test, before self-admin	0.8	0.8	2.4	-0.8	1.5	-0.3	0.9	-0.4
Time to tail flick, test, after self-admin	0.0	0.0	0.0	-0.1	0.1	0.1	-0.0	-0.0
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	0.6	-0.4	-0.7	0.2	0.1
Delta time to tail flick, test, before/after SA	1.9	1.7	2.9	1.4	-1.7	0.7	-1.4	1.0
Tibia length	0.5	1.4	4.2	1.5	-2.0	-0.2	-0.8	0.2
Ambulatory time before self-admin	0.5	0.5	1.0	-0.1	-0.6	-1.0	0.6	-0.8
Ambulatory time after self-admin	1.2	1.3	2.8	-1.2	0.1	-1.0	1.3	-1.7
Bone: tissue strength	0.5	0.4	0.8	-0.5	0.2	-0.8	0.7	-0.9
Total heroin consumption	1.6	1.9	5.6	1.3	-2.4	-1.2	-0.7	0.0
Bone: trabecular number	2.4	3.7	7.3	-1.3	-0.2	-2.7	2.2	-2.2
Bone: trabecular spacing	0.5	0.7	1.4	0.3	0.5	1.2	-0.8	1.0
Bone: trabecular thickness	1.8	2.2	3.0	-1.6	1.2	-1.4	1.7	-1.4
Bone: trabecular tissue density	0.7	1.0	2.3	-0.9	1.4	1.5	-0.2	0.3
Water consumed over 24 hours	0.2	0.2	0.5	0.4	-0.5	-0.7	0.0	-0.0
Number of responses in last shaping day	0.2	0.2	0.6	-0.4	0.3	0.8	-0.3	0.4