Hub : Genes

Majin

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Majin	0.03	0.02	5.1e-03	0.01	0.01	-0	0	2.8e-02	6.6e-02	9.6e-01	1.9e-01
2	pVTA	gene expression	Majin	0.13	0.08	1.2e-04	0.05	0.07	0.06	0.06	2.8e-03	5.5e-04	1.1e-03	1.1e-03
3	BLA	gene expression	Majin	0.12	0.07	1.9e-04	0.04	0.06	0.05	0.05	5.6e-03	2.5e-04	1.1e-03	1.7e-03
4	Brain	gene expression	Majin	0.05	0.04	8.7e-03	0.01	0.01	0	0.01	8.5e-02	1.5e-02	2.3e-01	3.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.6	0.9	1.7	-0.7	1.2	1.3	0.4
Area under the delay curve	0.3	0.3	1.0	0.4	0.2	-0.2	-1.0
BMI with tail	3.0	9.9	17.9	-2.9	4.2	3.4	1.2
BMI without tail	1.4	2.8	6.4	-1.6	2.5	1.5	0.1
Body weight	3.6	15.1	22.2	-4.2	4.7	3.6	2.7
Weight adjusted by age	2.6	2.9	3.6	-1.7	1.6	1.7	1.9
Bone surface	5.9	10.4	14.0	-2.8	3.0	3.7	3.2
Bone volume	2.7	4.7	8.0	-1.5	1.8	2.8	2.3
Breakpoint value in progressive ratio session	3.6	4.0	4.5	-2.0	1.8	2.1	2.0
Number of licking bursts	0.4	0.4	0.5	-0.7	0.5	0.7	0.7
Context. condit. distance diff. score	2.0	2.4	3.0	1.6	-1.3	-1.5	-1.7
Locomotion velocity, session 1	0.1	0.2	0.4	0.0	0.2	-0.6	-0.4
Locomotion distance, session 1	0.4	0.5	1.4	-0.6	1.2	0.4	-0.3
Locomotion velocity, session 2	2.5	2.9	4.8	-1.8	2.2	1.6	1.0
Locomotion distance, session 2	0.5	0.7	1.7	-0.8	1.3	0.4	-0.3
Locomotion velocity, session 3	0.2	0.3	0.7	0.5	0.1	-0.4	-0.8
Locomotion distance, session 3	0.1	0.1	0.1	0.2	-0.1	-0.3	-0.4
Stereotopy head waving bouts, day 3	0.6	0.7	1.5	0.9	-0.2	-0.8	-1.2
Stereotopy head waving duration, day 3	0.5	0.7	1.0	1.0	-0.6	-0.7	-0.9
Locomotion velocity, session 7	0.4	0.5	1.2	0.8	-0.2	-0.2	-1.1
Locomotion distance, session 7	0.5	0.6	1.9	0.2	0.1	-0.7	-1.4
Stereotopy head waving bouts, day 7	0.2	0.2	0.4	0.5	-0.3	0.6	0.4
Stereotopy head waving duration, day 7	1.5	1.8	3.2	-1.0	1.2	1.8	1.3
Locomotion velocity, session 8	0.5	0.6	1.3	-1.1	1.1	0.0	0.3
Locomotion distance, session 8	0.1	0.2	0.4	0.5	0.0	-0.2	-0.7
Degree of sensitization distance	0.1	0.1	0.4	-0.0	0.3	-0.2	-0.7
Degree of sensitization stereotypy	1.2	1.3	2.5	-0.6	0.6	1.6	1.3
Conditioned locomotion	1.4	1.6	2.4	-1.6	1.5	0.9	1.0
Cocaine response after cond. corrected	2.2	2.5	3.3	1.5	-1.1	-1.8	-1.8
Cocaine response after cond. not corrected	1.6	1.8	2.4	1.3	-0.9	-1.5	-1.5
Cocaine response before conditioning	1.0	1.3	1.7	-1.0	0.8	1.3	1.3
Saline control response	3.3	4.3	6.8	-2.6	2.5	1.5	1.4
Bone: connectivity density	2.5	3.9	5.1	-1.9	2.3	2.2	1.4
Bone: cortical apparent density	0.1	0.1	0.4	-0.7	0.3	0.1	-0.1
Bone: cortical area	1.1	1.6	2.6	-1.0	1.0	1.4	1.6
Bone: cortical porosity	0.1	0.1	0.2	-0.3	0.4	0.4	-0.0
Bone: cortical porosity	0.5	0.6	0.9	-0.9	0.9	0.7	0.4
Bone: cortical thickness	1.6	2.6	4.5	-2.1	1.8	1.0	1.3
Bone: cortical thickness	0.3	0.3	0.5	-0.7	0.6	-0.6	-0.3
Bone: cortical tissue density	0.1	0.2	0.6	-0.8	0.3	0.1	-0.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.5	0.5	0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.1	-0.0	-0.0	-0.2
Condit. Reinf. active responses	0.1	0.1	0.1	-0.3	0.3	0.4	-0.0
Condit. Reinf. inactive responses	0.0	0.1	0.2	0.1	0.1	0.4	0.1
Incentive salience index mean	0.3	0.3	0.7	-0.6	0.8	0.5	-0.1
Condit. Reinf. lever presses	0.5	0.7	1.0	-0.7	0.9	1.0	0.7
Condit. Reinf. active minus inactive responses	0.1	0.2	0.2	0.4	-0.4	0.5	0.4
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.7	0.9	-0.7	0.6	0.6
Condit. Reinf. active responses	0.1	0.1	0.4	-0.1	0.1	0.6	0.3
Condit. Reinf. inactive responses	0.2	0.3	0.4	-0.6	0.6	0.0	-0.6
Condit. Reinf. lever presses	3.2	4.3	5.8	-1.8	1.6	2.4	2.4
Condit. Reinf. lever reinforcers received	0.3	0.5	1.0	-0.5	0.4	1.0	0.7
Conditioned reinforcement - actives	0.6	0.6	1.3	0.6	-0.7	0.5	1.1
Conditioned reinforcement - inactives	4.3	4.8	9.8	2.7	-3.1	-1.3	-0.7
Conditioned locomotion	6.8	8.2	14.1	3.3	-3.8	-2.4	-1.4
Patch foraging indifference point 0 sec	0.0	0.0	0.1	0.1	-0.3	-0.1	-0.2
Patch foraging indifference point AUC	4.3	4.9	5.6	-2.3	1.9	2.3	2.4
Delay disc. indifference point, 0s delay	0.8	0.9	2.3	0.8	0.0	-0.8	-1.5
Delay disc. indifference point, 16s delay	0.7	0.7	0.9	1.0	-0.9	-0.4	-0.9
Delay disc. indifference point, 2s delay	0.0	0.1	0.1	0.4	-0.0	0.0	-0.3
Delay disc. indifference point, 24s delay	0.5	0.5	1.0	0.4	-0.2	-0.9	-1.0
Delay disc. indifference point, 4s delay	0.8	0.8	2.1	0.6	0.1	-0.9	-1.5
Delay disc. indifference point, 8s delay	0.5	0.5	1.4	0.3	0.1	-0.7	-1.2
Indifference point function ln k	10.5	14.6	16.6	3.8	-3.3	-4.1	-4.1
Indifference point function log k	10.5	14.6	16.6	3.8	-3.3	-4.1	-4.1
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	0.0	-0.2	-0.4	-0.3
Patch foraging total patch changes 12 sec	4.6	5.9	8.0	-2.8	2.5	2.4	2.0
Patch foraging total patch changes 18 sec	0.9	1.2	1.8	-1.0	1.0	1.3	1.1
Patch foraging total patch changes 24 sec	2.4	3.0	4.0	-2.0	1.6	1.4	1.8
Patch foraging total patch changes 6 sec	0.7	1.0	1.9	-1.4	1.3	0.7	0.4
Patch foraging time to switch 0 sec	2.5	3.9	6.1	-1.7	2.1	2.5	1.4
Patch foraging water rate 0 sec	4.2	6.8	9.3	2.6	-3.0	-2.9	-1.7
Patch foraging water rate 12 sec	10.6	16.2	22.0	3.9	-4.0	-4.7	-3.4
Patch foraging water rate 18 sec	4.3	5.8	8.3	2.3	-2.1	-2.9	-2.4
Patch foraging water rate 24 sec	4.7	6.6	8.4	2.7	-2.5	-2.9	-2.0
Patch foraging water rate 6 sec	5.6	8.1	12.5	2.6	-2.6	-3.5	-2.6
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	1.0	0.0	-0.2	-0.3	-1.0
Distance traveled before self-admin	1.2	1.3	2.0	-0.8	0.8	1.4	1.4
Distance traveled after self-admin	0.4	0.4	0.7	-0.5	0.2	0.8	0.8
Extensor digitorum longus weight	7.0	27.6	36.7	-5.9	6.1	4.8	4.0
Bone: elastic displacement	2.3	2.6	5.0	1.2	-1.3	-2.2	-1.5
Bone: elastic work	0.3	0.4	0.7	-0.9	0.8	-0.5	-0.2
Bone: endosteal estimation	0.3	0.5	1.8	1.3	-0.5	0.1	-0.3
Bone: endosteal perimeter	0.4	0.8	2.3	1.5	-0.8	0.6	0.3
Epididymis fat weight	1.7	4.0	7.4	2.7	-2.2	-1.4	-1.4
Delta time in closed arm before/after self-admin	1.0	1.0	1.9	-0.1	0.3	-1.3	-1.4
Delta time in open arm before/after self-admin	0.9	0.8	1.9	-0.2	-0.1	1.2	1.4
Diff in mean of infusions in LGA sessions	0.4	0.4	0.7	-0.8	0.5	0.5	0.8
Delay discount exponential model param	0.2	0.3	0.8	-0.3	-0.2	0.2	0.9
Extinction: sum of active levers before priming	4.8	4.8	5.8	-2.4	2.4	2.3	1.6
Active lever presses in extinction session 6	4.1	4.0	7.1	-1.6	1.4	2.0	2.7
Bone: final force	3.5	5.6	6.1	-2.4	2.5	2.4	2.2
Bone: final moment	3.1	5.0	5.4	-2.2	2.3	2.3	2.1
Food consumed during 24 hour testing period	0.3	0.3	1.0	-0.2	-0.2	0.5	1.0
Glucose	1.2	1.9	3.4	1.8	-1.3	-0.8	-1.4
Heart weight	3.8	5.4	5.9	2.4	-2.1	-2.3	-2.4
Delay discount hyperbolic model param	0.2	0.2	0.7	-0.3	-0.2	0.2	0.8
Intermittent access intake day 1-15 change	0.7	0.7	1.5	0.9	-1.2	-0.1	0.7
Intermittent access intake escalation	0.5	0.5	1.2	0.8	-1.1	-0.1	0.5
Intermittent access intake escalation 2	0.4	0.4	0.8	0.4	-0.8	0.2	0.9
Intermitt. access day 1 inactive lever presses	1.9	2.0	3.3	1.7	-1.8	-1.0	-1.0
Intermitt. access day 15 inactive lever presses	1.7	1.9	4.1	1.8	-2.0	-0.6	-0.2
Intermitt. access escalation Index	4.2	3.7	6.4	1.8	-1.4	-1.8	-2.5
Intermittent access day 1 total infusions	3.3	3.9	7.3	2.7	-2.0	-1.1	-1.7
Intermittent access day 15 total infusions	5.4	6.0	11.2	3.3	-3.1	-1.4	-1.1
Intermittent access terminal intake (last 3 days)	3.2	3.5	7.5	2.7	-2.4	-0.6	-0.4
Intermittent access total infusions	2.6	2.9	6.3	2.5	-2.1	-0.6	-0.8
Intermittent access day 1 locomotion	3.0	3.1	4.4	2.1	-1.4	-1.3	-2.1
Intermittent access day 15 total locomotion	3.2	3.4	6.3	2.5	-2.4	-0.9	-0.8
Intermittent access total locomotion	3.4	3.8	8.1	2.8	-2.3	-0.7	-1.2
Intermittent access standard deviation	1.0	1.0	2.1	1.3	-1.5	-0.5	0.1
Left kidney weight	0.4	1.0	1.9	1.4	-1.4	-0.4	-0.4
Right kidney weight	0.2	0.6	1.3	0.5	-0.8	0.5	1.1
Cocaine induced anxiety	0.3	0.3	0.8	-0.0	0.0	0.6	0.9
Post-drug Anxiety	2.3	2.6	4.9	-1.3	1.1	1.6	2.2
Baseline Anxiety	1.8	1.9	3.3	-1.8	1.5	0.9	1.1
Tail length	0.4	1.1	2.1	-1.5	1.1	0.2	1.0
Length with tail	1.7	6.2	9.0	-3.0	2.6	1.8	2.4
Length without tail	2.0	4.4	6.1	-2.5	2.1	1.7	2.1
Times rat made contact with spout	0.2	0.3	0.4	-0.7	0.7	0.1	-0.3
Lifetime Intake	2.4	2.7	5.5	2.3	-1.8	-0.8	-1.2
Liver weight, left	0.0	0.0	0.1	0.3	-0.1	-0.1	-0.1
Liver weight, right	0.1	0.2	0.4	0.3	0.2	-0.7	-0.5
Locomotor activity	3.0	4.7	7.8	1.8	-1.9	-2.8	-2.0
Locomotor testing distance	4.6	7.6	12.7	2.3	-2.2	-3.6	-2.7
Locomotor testing rearing	3.6	5.6	8.3	2.1	-1.9	-2.9	-2.4
Locomotion in novel chamber	3.0	3.7	6.8	2.6	-2.6	-1.0	-0.4
Locomotion in novel chamber post-restriction	2.3	2.8	4.2	2.0	-2.0	-1.3	-1.1
Fecal boli incidents, locomotor time 1	1.1	1.2	2.6	-0.0	0.1	1.5	1.6
Change in fecal boli incidents, locomotor task	0.9	0.8	2.0	-0.1	0.4	-1.1	-1.4
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.8	0.8	-0.3	0.9	0.5
Bouts of movement, locomotor time 1	1.1	1.2	1.8	-1.4	0.7	1.1	1.1
Total resting periods, locomotor time 1	0.9	1.0	1.4	-1.2	0.5	1.2	1.1
Rest time, locomotor task time 1	1.1	1.2	1.8	1.3	-1.4	-1.0	-0.4
Distance moved, locomotor task time 1	0.2	0.2	0.3	-0.3	0.6	0.4	-0.2
Vertical activity count, locomotor time 1	1.3	1.4	1.6	1.2	-1.3	-1.1	-1.1
Time >=10cm from walls, locomotor time 2	0.5	0.5	1.0	-0.1	0.1	1.0	1.0
Bouts of movement, locomotor time 2	0.3	0.3	0.7	-0.9	0.4	0.5	0.2
Total resting periods, locomotor time 2	0.1	0.2	0.4	-0.6	0.3	0.4	0.0
Rest time, locomotor task time 2	2.0	2.3	3.7	1.9	-1.6	-1.3	-1.2
Distance moved, locomotor task time 2	0.9	1.1	1.7	-1.3	1.0	0.9	0.9
Vertical activity count, locomotor time 2	0.3	0.4	1.2	-0.1	-0.4	-1.1	-0.4
Light reinforcement 1	0.2	0.3	0.5	0.4	-0.7	-0.7	-0.4
Light reinforcement 2	0.7	1.0	1.6	1.2	-1.3	0.2	0.8
Bone: marrow area	0.3	0.6	2.0	1.4	-0.5	0.0	-0.5
Bone: maximum diameter	1.0	1.9	4.4	-0.5	0.6	1.6	2.1
Bone: maximum force	4.5	7.8	10.1	-2.6	2.9	3.2	2.5
Bone: maximum moment	3.9	6.7	8.6	-2.3	2.7	2.9	2.3
Mean time between licks in bursts	0.5	0.7	1.0	-1.0	0.9	-0.7	-0.6
Mean num. licks in bursts	0.5	0.6	1.0	0.6	-0.4	-0.9	-1.0
Cd content in liver	0.9	1.0	2.2	1.2	-1.5	-0.3	0.3
Co content in liver	3.1	3.7	6.1	1.3	-1.7	-2.5	-2.0
Cu content in liver	0.2	0.2	0.4	-0.5	0.5	0.6	0.1
Fe content in liver	0.4	0.5	1.1	-0.3	0.5	0.7	1.0
K content in liver	1.8	1.8	3.3	-1.3	1.8	1.4	0.6
Mg content in liver	0.3	0.3	0.5	-0.2	0.7	0.6	-0.5
Mn content in liver	3.6	4.0	5.2	-1.8	1.7	2.2	2.3
Na content in liver	1.6	1.7	2.6	-1.2	1.1	1.3	1.6
Rb content in liver	1.6	2.0	3.0	1.5	-1.2	-1.2	-1.7
Se content in liver	0.8	1.0	2.2	0.1	-0.1	1.4	1.5
Sr content in liver	3.3	3.0	4.0	-1.9	1.4	1.5	2.0
Zn content in liver	1.1	1.2	1.4	-1.2	1.2	1.2	0.8
Bone: minimum diameter	0.3	0.6	1.5	1.2	-0.5	0.2	-0.7
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.5	-0.3	-0.2	-0.4
Time in novel zone, hab. session 1	0.6	0.6	1.4	0.4	-0.5	-1.2	-0.8
Total zone transitions, hab. session 1	0.5	0.7	0.9	-1.0	0.9	0.9	0.5
Total locomotion distance, hab. session 1	0.2	0.2	0.4	0.7	-0.3	-0.2	-0.6
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.2	0.1	0.2	-0.3
Time in familiar zone, hab. session 2	0.4	0.4	1.2	0.0	0.1	-1.1	-0.8
Time in novel zone, hab. session 2	0.2	0.2	0.6	-0.2	0.2	0.8	0.3
Total zone transitions, hab. session 2	1.3	1.6	3.3	-1.2	1.8	1.3	0.2
Total locomotion distance, hab. session 2	0.2	0.3	0.7	0.1	0.6	0.1	-0.9
Locomotion velocity, hab. session 2	0.1	0.2	0.5	0.3	0.4	0.2	-0.7
Novel to familiar place preference ratio	2.5	2.6	4.4	-1.2	1.0	2.1	1.9
Novelty place preference	1.4	1.4	2.8	-0.7	0.6	1.7	1.4
Time in novel zone, NPP test	1.0	1.0	2.0	-0.6	0.5	1.4	1.2
Total zone transitions, NPP test	2.2	3.1	4.4	-1.8	2.1	1.8	1.2
Total locomotion distance, NPP test	0.1	0.1	0.3	-0.2	0.6	0.2	-0.4
Locomotion velocity, NPP test	0.1	0.1	0.3	-0.3	0.5	0.4	-0.3
Intraocular pressure	0.8	1.1	2.5	1.1	-1.6	-0.1	0.9
Delta distance traveled before/after self-admin	0.3	0.3	0.6	0.1	-0.3	-0.8	-0.7
Delta ambulatory time before/after self-admin	0.3	0.4	0.8	-0.1	-0.2	-0.9	-0.8
Parametrial fat weight	1.2	2.3	4.3	2.1	-1.5	-0.7	-1.5
Pavlov. Cond. lever latency	0.4	0.5	0.7	0.6	-0.8	-0.8	-0.5
Pavlov. Cond. magazine entry latency	0.4	0.5	1.1	-0.4	0.7	1.1	0.3
Pavlov. Cond. change in total contacts	0.5	0.5	1.4	-0.2	0.2	1.2	0.8
Pavlov. Cond. index score	0.3	0.4	0.7	-0.4	0.5	0.9	0.6
Pavlov. Cond. latency score	0.2	0.2	0.4	-0.3	0.5	0.6	0.3
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.1	0.3	0.2	-0.1
Pavlov. Cond. magazine entry number	0.6	0.7	1.2	0.6	-0.4	-1.1	-1.1
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.4	0.7	-1.2	-0.5	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.2	-0.6	0.7	1.1	0.8
Pavlov. Cond. response bias	0.2	0.2	0.5	-0.3	0.2	0.7	0.6
Pavlov. Cond. lever latency	1.1	1.4	2.3	0.8	-0.8	-1.5	-1.5
Pavlov. Cond. magazine entry latency	3.5	4.1	4.7	-2.1	2.2	2.1	1.6
Pavlov. Cond. change in total contacts	3.4	4.7	8.0	-1.6	1.4	2.8	2.5
Pavlov. Cond. index score	3.5	4.4	6.3	-1.9	1.8	2.5	2.2
Pavlov. Cond. latency score	3.0	3.7	5.4	-1.6	1.6	2.3	2.0
Pavlov. Cond. lever contacts	1.0	1.4	2.8	-0.9	0.7	1.3	1.7
Pavlov. Cond. magazine entry number	6.9	8.4	10.0	3.0	-2.8	-3.2	-2.6
Pavlov. Cond. intertrial magazine entries	0.9	1.2	1.8	1.3	-1.2	-1.0	-0.7
Pavlov. Cond. lever-magazine prob. diff.	3.9	5.0	6.8	-2.0	2.0	2.6	2.2
Pavlov. Cond. response bias	2.6	3.5	4.5	-1.7	1.5	2.1	2.1
Time in closed arm before self-admin	0.5	0.5	1.1	-0.2	0.2	1.0	1.0
Time in closed arm after self-admin	0.3	0.3	0.8	0.0	-0.0	-0.7	-0.9
Time in open arm before self-admin	2.9	3.1	6.4	0.8	-0.6	-2.2	-2.5
Time in open arm after self-admin	0.3	0.4	0.5	0.5	-0.7	-0.7	-0.4
Bone: periosteal estimation	0.3	0.7	1.3	0.2	0.3	1.1	1.1
Bone: periosteal perimeter	0.6	0.9	1.7	-0.3	0.5	1.3	1.3
Bone: post-yield work	2.4	3.3	8.7	-0.7	1.4	2.9	1.3
Progressive ratio test 1 active lever presses	2.4	2.5	4.1	2.0	-2.0	-1.1	-0.9
Progressive ratio test 1 breakpoint	2.2	2.3	3.7	1.9	-1.9	-1.1	-0.8
Progressive ratio test 1 inactive lever presses	1.5	1.7	1.9	1.4	-1.3	-1.2	-1.3
Progressive ratio test 2 active lever presses	2.9	3.1	5.8	2.4	-2.4	-0.9	-0.5
Progressive ratio test 2 breakpoint	4.1	4.7	8.3	2.7	-2.9	-1.5	-0.9
Progressive ratio test 2 inactive lever presses	6.1	7.1	12.2	3.5	-3.5	-1.5	-1.3
Incentive Sensitization - Responses	0.3	0.3	0.6	0.7	-0.8	0.2	0.2
Incentive Sensitization - Breakpoint	0.4	0.4	1.0	0.9	-1.0	0.0	0.1
Sum of active levers in priming session hrs 5-6	4.2	4.1	9.7	-1.4	0.6	2.1	3.1
Progressive ratio	2.9	3.3	4.9	-1.5	2.2	2.2	1.1
Food seeking constrained by brief footshock	0.2	0.3	0.3	-0.5	0.4	-0.5	-0.5
Seeking ratio, punishment vs. effort	3.4	4.2	7.2	1.4	-1.9	-2.7	-2.0
Retroperitoneal fat weight	4.1	13.6	20.7	4.5	-4.1	-2.9	-2.9
Reaction time number correct	0.2	0.3	0.6	-0.6	0.5	0.2	0.8
Reaction time mean minus median	4.6	6.0	8.3	-2.2	2.0	2.9	2.6
Reaction time mean minus median AUC	2.3	3.0	4.0	-1.6	1.4	1.9	2.0
Reaction time num false alarms	1.4	1.9	3.5	0.4	-0.5	-1.9	-1.9
Reaction time num false alarms AUC	0.7	0.9	1.9	-0.2	0.2	-1.3	-1.4
Reaction time trials correct on left	0.2	0.3	0.6	-0.6	0.5	0.2	0.8
Reaction time trials on left	0.3	0.4	0.7	-0.7	0.6	0.3	0.8
Reaction time mean	0.3	0.5	0.9	-0.4	-0.0	0.9	0.9
Reaction time mean AUC	0.3	0.5	1.0	-0.3	-0.1	1.0	0.8
Median of all reaction times	0.1	0.1	0.2	-0.0	-0.4	0.5	0.3
Reaction time omissions	1.0	1.3	1.9	-1.4	1.1	1.2	1.0
Reaction time false alarm rate	1.0	1.4	3.1	0.4	-0.4	-1.5	-1.7
Reaction time premature initiation rate	1.4	1.9	3.7	-1.9	1.9	0.2	0.2
Reaction time premature initiations	2.1	3.0	5.9	-2.4	2.3	0.5	0.9
Std. dev. reaction times	1.4	2.0	3.0	-1.2	0.9	1.7	1.7
Reaction time trials completed	0.3	0.4	0.7	-0.7	0.6	0.3	0.8
Reaction time trials AUC	0.1	0.2	0.3	-0.5	0.5	0.1	0.5
Run reversals in cocaine runway, females	1.0	0.9	1.9	-0.5	1.3	-0.2	-1.4
Run reversals in cocaine runway, males	0.4	0.4	0.8	0.5	-0.8	-0.9	0.0
Latency to leave start box in cocaine runway	0.1	0.1	0.1	0.2	0.1	0.3	-0.3
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.2	0.1	0.5	-0.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	-0.0	0.2	0.0	-0.0
Std. dev. time between licks in bursts	0.8	1.0	2.4	0.1	-0.1	-1.5	-1.2
Total sessions with >9 infusions	1.6	1.8	2.4	1.6	-1.1	-1.2	-1.5
Short access day 1 total inactive lever presses	3.8	4.2	4.9	2.2	-2.2	-1.8	-2.0
Short access day 10 total inactive lever presses	5.0	5.5	6.6	2.1	-2.1	-2.5	-2.6
Short access day 1 total infusions	2.3	2.4	3.5	1.9	-1.4	-1.0	-1.8
Short access day 10 total infusions	0.9	1.0	2.2	1.5	-0.7	-0.2	-1.2
Short access total infusions	1.0	1.1	1.8	1.3	-0.7	-0.7	-1.3
Short access day 1 locomotion	2.1	2.3	3.4	1.8	-1.2	-1.2	-1.8
Short access day 10 total locomotion	1.5	1.7	2.8	1.7	-1.0	-0.8	-1.5
Short access total locomotion	1.4	1.4	2.5	1.3	-0.8	-0.9	-1.6
One hour access (0.3 mA shock)	7.7	9.0	14.8	3.8	-3.7	-2.2	-1.6
Compulsive drug intake	1.3	1.3	3.0	-1.7	1.5	-0.1	-0.2
One hour access (shock baseline)	5.8	6.8	12.9	3.6	-3.5	-1.1	-0.5
Social response proportion	1.2	1.3	1.5	-1.1	1.0	1.2	1.2
Social responses	0.2	0.2	0.3	-0.6	0.5	0.3	0.6
Social time	0.2	0.3	0.4	-0.6	0.6	0.1	0.6
Soleus weight	3.6	10.5	13.8	3.7	-3.4	-3.0	-2.8
Bone: stiffness	3.9	6.2	8.9	-2.2	2.4	3.0	2.3
Tibialis anterior weight	10.3	35.3	42.6	-6.5	6.2	5.3	5.6
Time to tail flick, vehicle, before self-admin	0.8	0.9	1.4	-0.5	1.0	1.2	0.8
Time to tail flick, vehicle, after self-admin	1.2	1.3	3.6	-1.0	1.9	0.8	0.0
Time to tail flick, test, before self-admin	1.0	1.0	2.4	0.9	-0.3	-0.9	-1.6
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.1	0.1	0.0	0.2
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.9	-0.6	0.9	0.1	-0.3
Delta time to tail flick, test, before/after SA	1.6	1.4	3.3	-1.2	0.4	0.9	1.8
Tibia length	2.5	7.1	14.0	-1.8	1.4	3.0	3.7
Ambulatory time before self-admin	1.5	1.6	3.0	-0.7	0.5	1.6	1.7
Ambulatory time after self-admin	0.2	0.2	0.4	0.1	-0.3	0.7	0.5
Bone: tissue strength	0.2	0.2	0.3	-0.2	0.1	0.6	0.5
Total heroin consumption	5.3	6.2	8.1	-2.8	2.7	2.4	2.0
Bone: trabecular number	1.0	1.6	3.2	-0.8	1.0	1.8	1.2
Bone: trabecular spacing	0.8	1.0	1.8	0.5	-0.5	-1.3	-1.3
Bone: trabecular thickness	0.3	0.4	0.7	0.8	-0.7	-0.1	-0.5
Bone: trabecular tissue density	2.8	4.0	5.9	2.3	-2.4	-1.7	-1.3
Water consumed over 24 hours	0.3	0.4	0.9	-1.0	0.7	0.4	0.4
Number of responses in last shaping day	1.9	2.0	2.5	1.4	-1.4	-1.6	-1.3