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chr2:89,673,058-95,023,945

Best TWAS P=1.132583e-11 · Best GWAS P=7.136741e-12 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Tpd52	alternative polyA	ENSRNOT00000120271	0.05	0.02	top1	1	0.02	3.4e-03	6.7	6.7	2.1e-11	0.97	0.07	0.04	FALSE
2	Adipose	Tpd52	alternative polyA	ENSRNOT00000099506	0.05	0.02	top1	1	0.02	3.7e-03	6.7	-6.7	2.1e-11	-0.98	0.06	0.04	FALSE
3	Adipose	Tpd52	alternative polyA	ENSRNOT00000120271	0.05	0.02	top1	1	0.02	3.8e-03	6.7	6.7	2.1e-11	0.98	0.06	0.04	FALSE
4	Adipose	Tpd52	alternative TSS	ENSRNOT00000120271	0.04	0.01	top1	1	0.01	1.0e-02	6.5	-6.5	9.9e-11	-1.00	0.06	0.03	FALSE
5	Adipose	Zbtb10	alternative TSS	ENSRNOT00000081553	0.29	0.17	lasso	27	0.19	2.7e-20	6.6	-6.0	1.7e-09	-0.94	0.43	0.57	FALSE
6	Adipose	Zbtb10	alternative TSS	ENSRNOT00000087598	0.28	0.17	lasso	16	0.19	2.6e-20	6.6	6.0	1.9e-09	0.94	0.43	0.57	FALSE
7	Adipose	Snx16	gene expression	ENSRNOG00000009953	0.11	0.04	enet	157	0.06	1.2e-07	-3.0	-5.3	1.2e-07	-0.37	1.00	0.00	FALSE
8	Adipose	Fabp12	gene expression	ENSRNOG00000038825	0.14	0.08	top1	1	0.08	3.2e-09	5.6	-5.6	2.0e-08	-0.82	0.40	0.60	FALSE
9	Adipose	Hey1	gene expression	ENSRNOG00000062882	0.04	0.00	blup	2629	0.02	5.5e-03	-4.0	-5.6	1.7e-08	-0.90	0.51	0.27	FALSE
10	Adipose	Snx16	isoform ratio	ENSRNOT00000083909	0.03	0.01	top1	1	0.01	2.5e-02	5.7	5.7	1.5e-08	0.84	0.06	0.03	FALSE
11	Adipose	Zbtb10	isoform ratio	ENSRNOT00000081553	0.25	0.15	lasso	5	0.16	4.9e-17	6.6	-6.1	1.3e-09	-0.93	0.45	0.55	FALSE
12	Adipose	Zbtb10	isoform ratio	ENSRNOT00000087598	0.23	0.14	blup	2314	0.15	1.4e-16	6.6	6.2	7.6e-10	0.97	0.44	0.56	FALSE
13	Adipose	Fabp4	mRNA stability	ENSRNOG00000010805	0.05	0.03	top1	1	0.03	3.2e-04	5.7	5.7	1.5e-08	0.84	0.08	0.10	FALSE
14	BLA	Fabp4	gene expression	ENSRNOG00000010805	0.41	0.21	lasso	10	0.24	2.8e-13	5.3	5.4	8.8e-08	0.84	0.53	0.47	FALSE
15	BLA	Pmp2	gene expression	ENSRNOG00000022707	0.10	0.08	lasso	1	0.08	5.9e-05	5.3	5.3	8.8e-08	0.81	0.46	0.48	FALSE
16	BLA	NA	gene expression	ENSRNOG00000049075	0.20	0.06	blup	2083	0.08	3.5e-05	5.4	5.5	4.2e-08	0.83	0.84	0.16	FALSE
17	BLA	Zfp704	gene expression	ENSRNOG00000054426	0.08	0.01	blup	2020	0.03	7.8e-03	5.4	-5.7	1.6e-08	-0.79	0.36	0.14	FALSE
18	BLA	Pag1	gene expression	ENSRNOG00000061328	0.06	0.01	top1	1	0.01	1.2e-01	5.4	-5.4	7.9e-08	-0.88	0.08	0.04	FALSE
19	BLA	Hey1	gene expression	ENSRNOG00000062882	0.07	0.03	top1	1	0.03	1.5e-02	6.7	6.7	2.6e-11	0.98	0.10	0.04	FALSE
20	BLA	NA	gene expression	ENSRNOG00000066286	0.06	0.02	lasso	20	0.02	2.0e-02	5.5	-5.5	4.8e-08	-0.84	0.44	0.11	FALSE
21	BLA	Slc10a5	gene expression	ENSRNOG00000067758	0.16	0.08	top1	1	0.08	5.3e-05	5.6	-5.6	2.8e-08	-0.84	0.12	0.08	FALSE
22	BLA	Snx16	isoform ratio	ENSRNOT00000096600	0.10	0.04	top1	1	0.04	2.8e-03	5.3	5.3	1.5e-07	0.84	0.08	0.04	FALSE
23	BLA	Zfp704	mRNA stability	ENSRNOG00000054426	0.08	0.00	blup	2020	0.03	1.3e-02	5.4	-5.7	1.2e-08	-0.82	0.44	0.17	FALSE
24	Brain	Fabp4	gene expression	ENSRNOG00000010805	0.18	0.10	top1	1	0.10	6.0e-10	5.4	5.4	7.8e-08	0.83	0.71	0.29	FALSE
25	Brain	NA	gene expression	ENSRNOG00000049075	0.23	0.15	top1	1	0.15	6.3e-14	6.5	6.5	7.0e-11	0.88	0.15	0.85	FALSE
26	Brain	Zfp704	gene expression	ENSRNOG00000054426	0.03	0.01	top1	1	0.01	2.3e-02	6.7	-6.7	2.1e-11	-0.93	0.06	0.04	FALSE
27	Brain	NA	gene expression	ENSRNOG00000066793	0.04	0.01	top1	1	0.01	1.5e-02	5.3	-5.3	1.4e-07	-0.88	0.07	0.03	FALSE
28	Brain	Snx16	isoform ratio	ENSRNOT00000083909	0.09	0.05	top1	1	0.05	1.7e-05	5.3	5.3	1.4e-07	0.83	0.27	0.07	FALSE
29	Brain	Tpd52	isoform ratio	ENSRNOT00000117383	0.03	0.00	enet	45	0.00	1.6e-01	-3.9	5.5	3.3e-08	0.90	0.34	0.23	FALSE
30	Brain	Tpd52	intron excision ratio	chr2:92804650:92812941	0.04	0.00	blup	2108	0.01	1.9e-02	-3.6	6.1	1.3e-09	0.80	0.38	0.28	FALSE
31	Brain	Tpd52	intron excision ratio	chr2:92805700:92811676	0.04	0.01	top1	1	0.01	1.5e-02	6.7	-6.7	1.7e-11	-0.98	0.07	0.04	FALSE
32	Brain	Zbtb10	intron excision ratio	chr2:92498889:92508405	0.03	0.00	top1	1	0.00	4.5e-01	6.5	-6.5	6.7e-11	-0.91	0.07	0.03	FALSE
33	Brain	Mrps28	mRNA stability	ENSRNOG00000032630	0.08	0.01	blup	2057	0.03	1.8e-03	6.6	5.6	2.1e-08	0.91	0.64	0.34	FALSE
34	Brain	Zfp704	mRNA stability	ENSRNOG00000054426	0.07	0.05	top1	1	0.05	2.6e-05	6.5	-6.5	6.3e-11	-0.92	0.18	0.23	FALSE
35	IL	Zc2hc1a	alternative polyA	ENSRNOT00000095126	0.29	0.01	blup	2421	0.01	1.9e-01	6.3	-5.8	5.9e-09	-0.67	0.24	0.25	FALSE
36	IL	Zc2hc1a	alternative polyA	ENSRNOT00000109624	0.32	-0.01	blup	2421	0.02	1.3e-01	6.3	5.3	1.3e-07	0.58	0.23	0.18	FALSE
37	IL	Zc2hc1a	alternative polyA	ENSRNOT00000095126	0.34	0.01	blup	2421	0.02	9.7e-02	6.3	-5.7	1.5e-08	-0.66	0.26	0.29	FALSE
38	IL	Zc2hc1a	alternative polyA	ENSRNOT00000109624	0.30	-0.01	blup	2421	0.01	1.9e-01	6.3	5.7	1.4e-08	0.66	0.25	0.25	FALSE
39	IL	Fabp4	gene expression	ENSRNOG00000010805	0.76	0.17	enet	6	0.17	5.7e-05	5.7	5.5	3.1e-08	0.82	0.35	0.60	FALSE
40	IL	NA	gene expression	ENSRNOG00000049075	0.27	0.09	top1	1	0.09	4.0e-03	5.3	5.3	9.0e-08	0.87	0.11	0.05	FALSE
41	IL	Tpd52	mRNA stability	ENSRNOG00000011441	0.30	0.12	top1	1	0.12	7.2e-04	6.7	-6.7	1.8e-11	-0.97	0.11	0.06	FALSE
42	Liver	Zbtb10	alternative TSS	ENSRNOT00000081553	0.11	0.04	top1	1	0.04	3.4e-05	5.3	-5.3	9.1e-08	-0.97	0.20	0.02	FALSE
43	Liver	Zbtb10	alternative TSS	ENSRNOT00000087598	0.09	0.04	top1	1	0.04	6.9e-05	5.3	5.3	9.1e-08	0.97	0.14	0.03	FALSE
44	Liver	NA	gene expression	ENSRNOG00000049075	0.04	0.01	enet	8	0.02	1.4e-03	-3.3	6.1	8.2e-10	0.83	0.45	0.35	FALSE
45	Liver	Zbtb10	isoform ratio	ENSRNOT00000081553	0.16	0.04	top1	1	0.04	3.0e-05	5.3	-5.3	9.1e-08	-0.97	0.22	0.02	FALSE
46	Liver	Zbtb10	isoform ratio	ENSRNOT00000087598	0.15	0.04	top1	1	0.04	7.8e-05	5.3	5.3	9.1e-08	0.97	0.14	0.03	FALSE
47	Liver	Mrps28	intron excision ratio	chr2:92820902:92855850	0.17	0.09	blup	2056	0.10	2.5e-11	-3.6	-5.2	2.6e-07	-0.62	1.00	0.00	FALSE
48	Liver	Tpd52	mRNA stability	ENSRNOG00000011441	0.07	0.04	top1	1	0.04	7.4e-05	6.7	-6.7	2.1e-11	-0.99	0.10	0.10	FALSE
49	NAcc2	Pmp2	gene expression	ENSRNOG00000022707	0.17	0.08	top1	1	0.08	4.8e-05	5.3	5.3	8.8e-08	0.83	0.27	0.11	FALSE
50	NAcc2	Pag1	gene expression	ENSRNOG00000061328	0.07	0.02	top1	1	0.02	3.5e-02	6.6	-6.6	3.8e-11	-0.91	0.08	0.04	FALSE
51	NAcc2	NA	gene expression	ENSRNOG00000066793	0.16	0.04	blup	2041	0.04	2.9e-03	5.3	-5.8	7.2e-09	-0.81	0.62	0.33	FALSE
52	OFC	Fabp4	gene expression	ENSRNOG00000010805	0.43	0.08	top1	1	0.08	7.4e-03	5.7	5.7	1.5e-08	0.83	0.10	0.06	FALSE
53	OFC	Pmp2	gene expression	ENSRNOG00000022707	0.31	0.02	enet	17	0.03	7.2e-02	-3.0	5.9	3.4e-09	0.83	0.23	0.13	FALSE
54	OFC	Mrps28	gene expression	ENSRNOG00000032630	0.44	0.11	top1	1	0.11	1.5e-03	6.7	6.7	1.8e-11	1.00	0.10	0.06	FALSE
55	OFC	NA	gene expression	ENSRNOG00000049075	0.37	0.08	top1	1	0.08	6.3e-03	5.3	5.3	1.0e-07	0.88	0.11	0.05	FALSE
56	OFC	Hey1	gene expression	ENSRNOG00000062882	0.19	0.13	top1	1	0.13	6.0e-04	6.5	6.5	7.9e-11	0.96	0.14	0.05	FALSE
57	PL	Fabp4	gene expression	ENSRNOG00000010805	0.59	0.14	top1	1	0.14	4.1e-04	5.7	5.7	1.1e-08	0.83	0.10	0.07	FALSE
58	PL	Mrps28	gene expression	ENSRNOG00000032630	0.30	0.03	top1	1	0.03	7.0e-02	6.8	6.8	1.1e-11	0.99	0.10	0.06	TRUE
59	PL	NA	gene expression	ENSRNOG00000049075	0.51	0.08	enet	9	0.24	2.5e-06	5.4	5.6	2.1e-08	0.81	0.80	0.13	FALSE
60	PL2	Fabp4	gene expression	ENSRNOG00000010805	0.43	0.24	top1	1	0.24	1.8e-13	5.3	5.3	9.0e-08	0.83	0.74	0.26	FALSE
61	PL2	Pmp2	gene expression	ENSRNOG00000022707	0.18	0.10	top1	1	0.10	4.2e-06	5.3	5.3	9.0e-08	0.83	0.24	0.10	FALSE
62	PL2	Mrps28	gene expression	ENSRNOG00000032630	0.08	0.02	top1	1	0.02	2.3e-02	6.5	6.5	8.4e-11	0.99	0.08	0.04	FALSE
63	PL2	NA	gene expression	ENSRNOG00000049075	0.42	0.23	top1	1	0.23	1.4e-12	5.4	5.4	8.1e-08	0.87	0.99	0.01	FALSE
64	PL2	Hey1	gene expression	ENSRNOG00000062882	0.11	0.05	top1	1	0.05	1.1e-03	6.7	6.7	1.8e-11	0.93	0.10	0.05	FALSE
65	PL2	tGap1	isoform ratio	ENSRNOT00000082912	0.09	0.02	enet	45	0.03	6.7e-03	5.2	-5.2	1.5e-07	-0.77	0.30	0.23	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.