Best TWAS P=1.377141e-07 · Best GWAS P=8.17287e-08 conditioned to 0.0604391
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | BLA | Cyp7b1 | gene expression | ENSRNOG00000009730 | 0.43 | 0.27 | enet | 71 | 0.29 | 5.8e-16 | -5.2 | 5.1 | 3.2e-07 | -0.77 | 0.55 | 0.45 | FALSE |
| 2 | Brain | Cyp7b1 | intron excision ratio | chr2:100638373:100669465 | 0.04 | 0.02 | enet | 17 | 0.04 | 2.6e-04 | -5.2 | 5.3 | 1.4e-07 | -0.81 | 0.56 | 0.38 | TRUE |
| 3 | LHb | Armc1 | gene expression | ENSRNOG00000013253 | 0.31 | 0.20 | top1 | 1 | 0.20 | 1.4e-05 | -5.2 | -5.2 | 2.1e-07 | 0.92 | 0.09 | 0.09 | FALSE |
| 4 | NAcc | Mtfr1 | gene expression | ENSRNOG00000021359 | 0.06 | 0.04 | top1 | 1 | 0.04 | 3.3e-04 | -5.2 | -5.2 | 1.5e-07 | 0.94 | 0.06 | 0.08 | FALSE |
| 5 | PL | Cyp7b1 | gene expression | ENSRNOG00000009730 | 0.10 | 0.06 | blup | 2233 | 0.07 | 3.9e-06 | -5.2 | 5.2 | 2.0e-07 | -0.86 | 0.56 | 0.44 | FALSE |
| 6 | PL | Armc1 | gene expression | ENSRNOG00000013253 | 0.06 | 0.04 | top1 | 1 | 0.04 | 5.1e-04 | -5.1 | -5.1 | 3.1e-07 | 0.79 | 0.08 | 0.08 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.