Efcab7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Efcab7	0.02	0.01	5.3e-03	0.01	0.02	0	0.01	8.2e-03	6.3e-03	2.1e-01	4.1e-02
2	Eye	gene expression	Efcab7	0.44	0.23	7.0e-04	0.06	0.09	0	0.05	3.9e-02	1.8e-02	2.8e-01	5.9e-02
3	Adipose	gene expression	Efcab7	0.28	0.14	1.3e-03	0.02	0.03	0.02	0.02	1.0e-03	8.2e-04	1.1e-03	1.8e-03
4	LHb	intron excision ratio	chr5_114527793_114538940	0.82	0.11	1.1e-03	0.02	0.04	0.04	0.02	9.5e-02	4.7e-02	5.3e-02	1.1e-01
5	Liver	isoform ratio	NM_001191866.1	0.21	0.12	4.2e-03	0.03	0.03	0.01	0.03	7.0e-04	8.1e-04	8.0e-03	7.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.2	0.4	0.8	0.5	0.5	-0.9	-0.8	-0.1
Area under the delay curve	1.3	1.4	3.8	0.8	0.7	-2.0	1.4	-0.2
BMI with tail	0.3	1.1	2.1	-0.9	-0.9	1.0	-0.7	1.5
BMI without tail	0.2	0.5	0.6	-0.8	-0.8	0.6	0.7	-0.5
Body weight	0.2	0.7	1.7	0.2	0.1	0.8	-1.1	1.3
Weight adjusted by age	2.1	2.4	8.5	-1.2	-1.2	-2.9	0.7	-0.5
Bone surface	1.4	2.5	3.9	-1.7	-1.8	-2.0	-1.5	0.4
Bone volume	0.7	1.2	4.2	-0.7	-0.7	-2.1	-0.9	0.1
Breakpoint value in progressive ratio session	0.7	0.8	2.0	0.7	0.6	1.4	-0.7	0.8
Number of licking bursts	0.2	0.3	1.2	-0.1	-0.1	0.3	1.1	-0.0
Context. condit. distance diff. score	2.8	3.3	5.0	1.9	1.7	1.1	-2.2	2.0
Locomotion velocity, session 1	0.4	0.4	1.0	-0.7	-0.7	1.0	0.2	0.3
Locomotion distance, session 1	0.5	0.6	1.5	0.8	0.8	1.2	0.6	-0.1
Locomotion velocity, session 2	0.3	0.3	0.8	-0.0	-0.0	-0.8	0.4	-0.9
Locomotion distance, session 2	0.3	0.5	0.7	-0.6	-0.6	0.8	0.5	-0.9
Locomotion velocity, session 3	0.2	0.3	0.8	0.2	0.3	0.5	0.9	-0.4
Locomotion distance, session 3	0.1	0.1	0.4	0.1	0.1	-0.1	0.7	0.1
Stereotopy head waving bouts, day 3	0.4	0.5	1.1	1.0	1.0	-0.1	-0.0	-0.5
Stereotopy head waving duration, day 3	0.6	0.8	1.4	1.2	1.2	0.4	0.2	-0.9
Locomotion velocity, session 7	0.5	0.6	1.3	1.1	1.1	0.3	-0.5	-0.2
Locomotion distance, session 7	0.3	0.3	0.8	0.9	0.9	0.2	-0.5	0.0
Stereotopy head waving bouts, day 7	0.3	0.4	0.8	-0.9	-0.9	-0.5	0.1	0.1
Stereotopy head waving duration, day 7	0.6	0.8	1.7	-1.3	-1.2	-0.3	0.6	-0.4
Locomotion velocity, session 8	0.2	0.2	0.5	0.4	0.4	0.7	-0.3	0.3
Locomotion distance, session 8	0.6	0.9	2.1	1.0	0.9	1.4	-0.8	0.4
Degree of sensitization distance	0.3	0.3	1.3	-0.1	-0.1	-0.2	-1.1	0.5
Degree of sensitization stereotypy	0.6	0.7	1.5	-1.2	-1.2	-0.3	0.6	-0.2
Conditioned locomotion	0.5	0.6	2.1	0.1	0.1	1.5	0.8	0.2
Cocaine response after cond. corrected	0.4	0.5	1.3	-0.8	-0.7	0.2	1.1	-0.4
Cocaine response after cond. not corrected	0.3	0.3	0.6	-0.8	-0.6	0.5	0.4	-0.2
Cocaine response before conditioning	0.4	0.4	1.9	-0.2	-0.1	0.4	-1.4	0.1
Saline control response	0.0	0.1	0.3	-0.1	-0.0	0.5	0.0	-0.1
Bone: connectivity density	1.3	2.0	3.3	-1.8	-1.8	-1.7	-0.8	0.2
Bone: cortical apparent density	4.1	5.4	10.5	3.1	3.2	2.4	0.2	-1.0
Bone: cortical area	0.3	0.4	1.0	-0.6	-0.6	0.4	0.5	-1.0
Bone: cortical porosity	0.3	0.3	0.7	-0.8	-0.8	-0.5	0.1	0.4
Bone: cortical porosity	0.5	0.5	1.1	-1.0	-1.1	-0.2	0.1	0.6
Bone: cortical thickness	0.2	0.3	1.1	0.4	0.4	1.1	0.2	-0.2
Bone: cortical thickness	0.3	0.3	0.8	0.2	0.1	0.7	-0.9	0.6
Bone: cortical tissue density	4.0	5.3	10.2	3.1	3.2	2.4	0.2	-1.0
Condit. Reinf. active minus inactive responses	0.5	0.5	0.8	-0.9	-0.9	0.8	0.5	-0.4
Condit. Reinf. active-inactive response ratio	0.6	0.6	2.2	-0.6	-0.6	1.5	0.3	0.0
Condit. Reinf. active responses	0.8	1.0	2.1	-1.4	-1.4	0.4	0.8	-0.5
Condit. Reinf. inactive responses	0.3	0.4	0.9	-0.9	-0.9	-0.0	0.5	-0.3
Incentive salience index mean	0.9	1.0	2.1	-1.2	-1.2	1.4	0.4	-0.5
Condit. Reinf. lever presses	0.9	1.2	5.1	-0.6	-0.5	2.3	-0.4	-0.1
Condit. Reinf. active minus inactive responses	0.9	1.1	2.6	0.8	0.8	1.6	-1.3	0.1
Condit. Reinf. active-inactive response ratio	0.6	0.6	2.8	0.2	0.3	1.7	-0.4	-0.4
Condit. Reinf. active responses	1.0	1.4	4.4	0.5	0.5	1.3	-2.1	0.6
Condit. Reinf. inactive responses	0.8	1.0	2.1	1.0	1.0	0.6	-1.5	0.5
Condit. Reinf. lever presses	1.6	2.2	5.4	-2.3	-2.3	-0.3	-0.5	-0.3
Condit. Reinf. lever reinforcers received	0.6	0.9	3.6	0.1	0.1	0.8	-1.9	0.5
Conditioned reinforcement - actives	0.3	0.3	1.1	0.1	0.1	1.1	0.4	-0.5
Conditioned reinforcement - inactives	0.6	0.7	1.7	0.4	0.3	0.3	-1.2	1.3
Conditioned locomotion	0.7	0.8	3.9	-0.2	-0.2	2.0	0.4	0.2
Patch foraging indifference point 0 sec	3.9	6.3	12.3	-3.5	-3.5	-2.1	-0.4	1.6
Patch foraging indifference point AUC	0.7	0.8	1.6	-1.3	-1.1	-0.8	0.4	-0.7
Delay disc. indifference point, 0s delay	1.9	2.1	4.2	2.0	2.0	-0.7	-0.6	1.3
Delay disc. indifference point, 16s delay	1.2	1.2	2.2	-1.2	-1.1	-1.2	1.5	-0.2
Delay disc. indifference point, 2s delay	1.6	1.8	6.0	1.0	0.9	-2.4	-0.3	1.1
Delay disc. indifference point, 24s delay	0.6	0.6	2.4	0.1	0.1	0.4	1.5	-0.7
Delay disc. indifference point, 4s delay	2.2	2.3	3.9	2.0	1.9	-1.7	1.0	-0.2
Delay disc. indifference point, 8s delay	1.0	1.0	1.6	1.3	1.3	-0.5	1.1	-0.4
Indifference point function ln k	0.5	0.8	1.0	1.0	0.9	0.9	-0.8	0.7
Indifference point function log k	0.5	0.8	1.0	1.0	0.9	0.9	-0.8	0.7
Patch foraging total patch changes 0 sec	3.7	5.9	11.5	-3.4	-3.4	-2.0	-0.4	1.6
Patch foraging total patch changes 12 sec	1.0	1.3	2.5	-1.6	-1.5	-1.1	0.5	0.4
Patch foraging total patch changes 18 sec	2.1	2.7	5.5	-2.4	-2.3	-0.6	-0.6	1.3
Patch foraging total patch changes 24 sec	1.5	1.9	2.8	-1.6	-1.6	-0.4	-1.1	1.7
Patch foraging total patch changes 6 sec	2.0	3.0	7.7	-2.8	-2.6	-0.6	0.2	0.6
Patch foraging time to switch 0 sec	1.8	2.7	4.4	1.4	1.5	1.7	2.1	-1.5
Patch foraging water rate 0 sec	1.0	1.5	2.6	-1.5	-1.5	-1.6	-0.3	0.5
Patch foraging water rate 12 sec	2.1	3.2	5.6	-2.2	-2.4	-0.4	-1.4	1.8
Patch foraging water rate 18 sec	0.4	0.5	1.1	-0.8	-0.8	0.4	-0.3	1.1
Patch foraging water rate 24 sec	0.5	0.7	2.3	-0.2	-0.3	0.0	-1.0	1.5
Patch foraging water rate 6 sec	0.4	0.6	1.4	-0.1	-0.2	-0.9	-1.2	0.8
Seeking ratio, delayed vs. immediate footshock	1.9	2.2	7.5	-0.0	-0.3	-0.4	-1.9	2.7
Distance traveled before self-admin	0.4	0.5	1.0	-0.1	-0.2	-0.5	-1.0	1.0
Distance traveled after self-admin	0.6	0.7	1.1	-1.0	-1.0	-1.0	0.2	-0.0
Extensor digitorum longus weight	0.7	2.7	4.6	1.3	1.2	1.6	-1.8	2.1
Bone: elastic displacement	0.6	0.6	0.8	0.8	0.8	0.5	-0.9	0.9
Bone: elastic work	0.7	0.9	1.2	1.1	1.1	0.5	-0.9	0.8
Bone: endosteal estimation	0.5	1.0	2.0	-0.9	-1.0	-1.1	-1.4	0.5
Bone: endosteal perimeter	0.7	1.5	2.4	-1.6	-1.5	-1.4	0.2	-0.9
Epididymis fat weight	1.6	3.8	12.2	1.8	1.8	3.5	-0.7	-0.1
Delta time in closed arm before/after self-admin	0.3	0.3	0.8	-0.5	-0.5	-0.1	-0.5	0.9
Delta time in open arm before/after self-admin	1.6	1.6	3.1	-1.0	-1.0	-0.7	1.5	-1.8
Diff in mean of infusions in LGA sessions	0.8	0.8	1.5	0.5	0.5	0.9	-1.2	1.2
Delay discount exponential model param	1.2	1.3	3.5	-0.7	-0.7	1.9	-1.4	0.2
Extinction: sum of active levers before priming	1.5	1.5	2.1	1.1	1.0	-1.1	-1.5	1.4
Active lever presses in extinction session 6	1.5	1.5	3.1	-0.2	-0.3	1.6	-1.3	1.8
Bone: final force	0.4	0.6	1.4	0.7	0.8	1.2	-0.3	-0.7
Bone: final moment	0.1	0.2	0.7	0.0	0.1	0.9	-0.5	-0.3
Food consumed during 24 hour testing period	0.6	0.7	2.1	0.6	0.6	0.8	0.4	-1.4
Glucose	0.5	0.7	1.5	-0.4	-0.4	0.9	-1.0	1.2
Heart weight	2.5	3.6	5.1	2.0	2.0	1.8	-2.3	1.3
Delay discount hyperbolic model param	1.4	1.5	3.7	-0.9	-0.9	1.9	-1.4	0.2
Intermittent access intake day 1-15 change	1.8	1.8	4.1	0.9	1.1	0.6	1.6	-2.0
Intermittent access intake escalation	1.8	1.8	3.8	0.8	1.0	0.5	1.7	-1.9
Intermittent access intake escalation 2	1.1	1.1	1.7	0.7	0.9	1.2	0.9	-1.3
Intermitt. access day 1 inactive lever presses	2.9	3.1	6.1	-1.0	-1.2	-1.3	-2.5	2.3
Intermitt. access day 15 inactive lever presses	1.2	1.3	3.0	0.8	0.8	1.3	-1.7	0.7
Intermitt. access escalation Index	3.0	2.7	9.5	-0.1	-0.1	-3.1	1.0	-1.7
Intermittent access day 1 total infusions	0.1	0.1	0.5	-0.1	-0.1	0.3	0.7	-0.2
Intermittent access day 15 total infusions	1.8	2.1	5.5	0.6	0.7	0.9	2.3	-1.8
Intermittent access terminal intake (last 3 days)	0.5	0.5	1.6	0.3	0.3	0.3	1.3	-0.9
Intermittent access total infusions	1.3	1.4	4.0	0.3	0.3	1.3	2.0	-1.1
Intermittent access day 1 locomotion	1.4	1.5	2.6	-0.8	-0.8	1.6	1.6	-1.0
Intermittent access day 15 total locomotion	1.3	1.4	3.1	-0.8	-0.7	1.8	1.2	-1.1
Intermittent access total locomotion	1.5	1.8	4.2	-0.6	-0.6	2.1	1.6	-1.1
Intermittent access standard deviation	3.0	3.2	9.0	0.8	0.8	3.0	2.0	-1.1
Left kidney weight	0.9	2.6	5.0	0.9	0.8	1.3	-2.2	2.2
Right kidney weight	1.1	3.0	7.6	1.1	1.0	0.2	-2.8	2.2
Cocaine induced anxiety	1.7	1.9	4.8	0.6	0.6	-0.6	2.2	-2.0
Post-drug Anxiety	1.1	1.2	2.2	1.5	1.5	-0.5	0.8	-0.8
Baseline Anxiety	1.5	1.6	4.2	0.7	0.7	0.3	-2.0	1.7
Tail length	0.4	1.2	1.9	1.3	1.4	0.7	-0.0	-1.3
Length with tail	0.2	0.7	1.6	1.3	1.2	0.1	-0.6	0.1
Length without tail	0.5	1.1	3.1	0.3	0.2	-0.6	-1.3	1.8
Times rat made contact with spout	0.5	0.6	1.7	-0.6	-0.5	1.3	-0.5	0.6
Lifetime Intake	1.1	1.3	4.0	0.1	0.1	0.4	2.0	-1.5
Liver weight, left	1.1	1.7	2.9	1.7	1.6	1.4	-1.0	0.4
Liver weight, right	4.2	7.0	8.8	3.0	2.9	2.7	-2.5	2.0
Locomotor activity	0.2	0.3	0.5	-0.3	-0.3	-0.6	-0.7	0.6
Locomotor testing distance	1.2	1.9	3.3	-1.8	-1.8	-1.4	-0.8	0.6
Locomotor testing rearing	0.1	0.1	0.2	-0.4	-0.3	0.2	-0.3	0.3
Locomotion in novel chamber	0.4	0.5	1.1	-1.0	-1.0	0.4	-0.4	0.6
Locomotion in novel chamber post-restriction	1.1	1.3	3.0	-0.0	0.0	1.5	1.7	-1.1
Fecal boli incidents, locomotor time 1	0.6	0.7	2.2	-0.1	0.0	0.8	1.5	-0.8
Change in fecal boli incidents, locomotor task	0.4	0.4	0.8	0.6	0.5	-0.9	-0.7	0.4
Time >=10cm from walls, locomotor time 1	0.8	0.8	3.1	-0.2	-0.3	-1.8	0.8	-0.1
Bouts of movement, locomotor time 1	1.2	1.3	5.0	-0.5	-0.7	0.2	-0.9	2.2
Total resting periods, locomotor time 1	1.4	1.5	5.0	-0.6	-0.6	-0.5	-1.3	2.2
Rest time, locomotor task time 1	0.8	0.9	2.0	0.0	-0.1	-1.1	-1.4	1.1
Distance moved, locomotor task time 1	0.1	0.2	0.3	0.4	0.5	0.3	-0.1	-0.5
Vertical activity count, locomotor time 1	0.3	0.3	0.6	0.3	0.2	-0.8	0.4	-0.7
Time >=10cm from walls, locomotor time 2	1.5	1.6	2.6	1.6	1.5	0.9	-1.3	0.8
Bouts of movement, locomotor time 2	0.7	0.7	1.5	-1.2	-1.2	-0.5	0.1	0.7
Total resting periods, locomotor time 2	0.7	0.7	1.4	-1.1	-1.2	-0.7	0.3	0.5
Rest time, locomotor task time 2	0.9	1.1	4.5	-0.4	-0.5	-2.1	0.6	0.2
Distance moved, locomotor task time 2	2.1	2.4	4.9	1.3	1.4	1.8	-2.2	0.5
Vertical activity count, locomotor time 2	1.1	1.1	2.4	0.8	0.8	1.3	-1.5	0.6
Light reinforcement 1	0.7	1.2	2.7	0.4	0.4	1.5	-1.6	1.0
Light reinforcement 2	0.3	0.4	0.7	0.7	0.6	0.8	-0.6	0.4
Bone: marrow area	0.4	0.9	1.9	-0.9	-0.9	-0.9	-1.4	0.5
Bone: maximum diameter	0.6	1.0	1.6	-1.1	-1.0	-0.3	1.1	-1.3
Bone: maximum force	0.2	0.4	1.4	0.2	0.2	1.2	-0.4	-0.5
Bone: maximum moment	0.2	0.4	0.7	-0.6	-0.5	0.8	-0.8	0.0
Mean time between licks in bursts	3.0	4.2	9.0	3.0	3.0	0.6	-1.5	0.8
Mean num. licks in bursts	0.5	0.5	2.1	-0.4	-0.4	0.4	-1.5	0.4
Cd content in liver	2.3	2.5	4.3	-1.4	-1.5	0.0	-2.1	2.0
Co content in liver	2.7	3.2	9.1	0.3	0.2	0.7	-3.0	2.5
Cu content in liver	0.4	0.5	1.9	0.5	0.5	1.4	0.0	0.0
Fe content in liver	0.9	1.1	1.9	-1.2	-1.2	-0.1	-1.4	0.8
K content in liver	0.6	0.6	1.4	1.2	1.2	0.4	-0.1	-0.3
Mg content in liver	2.1	2.2	5.9	-0.5	-0.3	-0.4	2.1	-2.4
Mn content in liver	0.4	0.5	2.2	0.1	0.1	1.5	0.1	0.1
Na content in liver	2.3	2.4	3.6	1.8	1.8	1.4	-1.9	0.2
Rb content in liver	0.5	0.6	1.1	0.9	0.9	1.1	0.6	-0.0
Se content in liver	0.7	0.9	1.4	-1.0	-1.0	-0.5	-1.2	0.8
Sr content in liver	0.4	0.3	0.6	-0.4	-0.4	0.6	-0.8	0.6
Zn content in liver	0.9	1.0	1.5	-1.0	-0.9	0.4	1.2	-1.2
Bone: minimum diameter	0.9	1.7	3.1	-1.6	-1.6	-1.8	0.1	-0.3
Time in familiar zone, hab. session 1	1.5	1.4	2.3	1.5	1.5	1.3	-0.3	0.8
Time in novel zone, hab. session 1	3.2	3.1	6.0	-2.4	-2.4	-1.8	0.3	-0.6
Total zone transitions, hab. session 1	0.8	1.1	1.7	1.3	1.3	1.0	0.8	-0.5
Total locomotion distance, hab. session 1	0.2	0.2	0.5	0.7	0.6	-0.3	-0.6	0.2
Locomotion velocity, hab. session 1	0.1	0.2	0.4	0.7	0.6	-0.1	0.1	-0.2
Time in familiar zone, hab. session 2	0.8	0.8	3.3	0.5	0.5	1.8	0.5	0.4
Time in novel zone, hab. session 2	0.8	0.8	2.6	-0.8	-0.8	-1.6	-0.1	-0.4
Total zone transitions, hab. session 2	3.2	4.1	7.7	2.7	2.8	1.7	1.1	-1.1
Total locomotion distance, hab. session 2	1.7	2.2	5.1	2.3	2.2	0.6	0.3	-0.7
Locomotion velocity, hab. session 2	1.5	2.0	4.5	2.1	2.1	0.4	0.5	-0.9
Novel to familiar place preference ratio	0.6	0.7	1.5	-1.2	-1.2	-0.3	-0.6	0.1
Novelty place preference	0.6	0.6	0.9	-1.0	-0.9	-0.4	-0.9	0.4
Time in novel zone, NPP test	0.8	0.8	1.3	-1.1	-1.1	-0.4	-1.1	0.6
Total zone transitions, NPP test	1.1	1.5	2.7	1.6	1.6	1.0	1.0	-0.7
Total locomotion distance, NPP test	0.5	0.6	1.3	1.1	1.1	-0.6	0.3	-0.5
Locomotion velocity, NPP test	0.5	0.7	1.3	1.1	1.1	-0.4	0.5	-0.6
Intraocular pressure	0.4	0.5	1.1	0.2	0.1	-1.0	1.1	-0.7
Delta distance traveled before/after self-admin	1.1	1.2	1.9	-1.4	-1.3	-0.6	1.2	-0.8
Delta ambulatory time before/after self-admin	1.3	1.4	2.5	-1.1	-1.0	-1.0	1.6	-1.2
Parametrial fat weight	2.1	4.1	7.3	-2.5	-2.7	-1.8	-1.4	1.4
Pavlov. Cond. lever latency	0.9	1.2	1.9	1.4	1.4	-1.2	0.2	-0.8
Pavlov. Cond. magazine entry latency	0.6	0.7	3.1	0.1	0.2	1.8	0.6	-0.2
Pavlov. Cond. change in total contacts	0.7	0.7	1.4	-1.1	-1.1	1.2	0.0	-0.0
Pavlov. Cond. index score	0.6	0.8	2.6	-0.8	-0.8	1.6	-0.0	0.5
Pavlov. Cond. latency score	0.7	0.8	2.4	-0.9	-0.9	1.6	0.1	0.5
Pavlov. Cond. lever contacts	0.6	0.7	2.0	-0.8	-0.8	1.4	-0.1	0.6
Pavlov. Cond. magazine entry number	0.8	1.0	4.7	-0.2	-0.3	-2.2	-0.6	0.4
Pavlov. Cond. intertrial magazine entries	1.5	1.8	3.8	0.8	0.9	-0.3	1.9	-2.0
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	2.3	-0.8	-0.8	1.5	0.1	0.3
Pavlov. Cond. response bias	0.7	0.9	4.1	-0.3	-0.3	2.0	-0.1	0.4
Pavlov. Cond. lever latency	1.1	1.5	2.3	1.5	1.4	-0.3	-1.0	1.4
Pavlov. Cond. magazine entry latency	1.2	1.4	2.3	-1.5	-1.5	-0.1	1.2	-0.9
Pavlov. Cond. change in total contacts	1.1	1.5	2.9	-1.7	-1.7	-0.6	0.5	-1.0
Pavlov. Cond. index score	1.0	1.3	2.8	-1.7	-1.7	-0.1	0.5	-0.7
Pavlov. Cond. latency score	0.8	1.0	2.2	-1.5	-1.5	0.1	0.4	-0.5
Pavlov. Cond. lever contacts	1.6	2.2	3.9	-2.0	-1.9	-0.1	1.1	-1.6
Pavlov. Cond. magazine entry number	0.6	0.7	1.2	1.0	1.0	-0.1	-1.1	0.8
Pavlov. Cond. intertrial magazine entries	0.7	0.9	2.3	1.5	1.5	0.1	0.3	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	2.6	-1.6	-1.6	-0.2	0.5	-0.7
Pavlov. Cond. response bias	1.4	1.9	3.2	-1.8	-1.7	-0.2	1.1	-1.5
Time in closed arm before self-admin	1.4	1.6	3.7	0.1	0.2	1.0	1.9	-1.8
Time in closed arm after self-admin	0.3	0.3	1.0	-0.1	-0.0	0.6	1.0	-0.3
Time in open arm before self-admin	1.1	1.2	2.8	-0.4	-0.4	-0.9	-1.4	1.7
Time in open arm after self-admin	1.5	1.7	3.7	-1.5	-1.6	-1.9	0.0	-0.2
Bone: periosteal estimation	0.3	0.6	1.2	-1.0	-1.1	-0.6	-0.7	-0.2
Bone: periosteal perimeter	0.6	1.0	1.5	-1.2	-1.2	0.1	0.7	-1.2
Bone: post-yield work	0.9	1.3	2.6	-1.6	-1.6	1.1	-0.3	-0.1
Progressive ratio test 1 active lever presses	2.2	2.3	3.5	1.6	1.6	1.9	1.2	-1.1
Progressive ratio test 1 breakpoint	2.6	2.7	3.7	1.8	1.9	1.9	1.2	-1.1
Progressive ratio test 1 inactive lever presses	0.8	0.8	2.1	0.7	0.8	1.5	0.7	-0.6
Progressive ratio test 2 active lever presses	1.9	2.0	4.8	-0.1	0.0	1.6	2.2	-1.7
Progressive ratio test 2 breakpoint	1.9	2.2	4.5	-0.0	0.1	1.9	2.1	-1.7
Progressive ratio test 2 inactive lever presses	0.4	0.4	1.3	-0.3	-0.2	-0.1	0.9	-1.1
Incentive Sensitization - Responses	0.7	0.7	1.1	-0.8	-0.6	0.7	1.0	-1.0
Incentive Sensitization - Breakpoint	0.8	0.8	1.4	-0.8	-0.7	0.6	1.2	-1.1
Sum of active levers in priming session hrs 5-6	3.4	3.2	5.6	1.5	1.3	1.3	-2.4	2.3
Progressive ratio	0.6	0.7	1.5	0.6	0.6	0.6	1.0	-1.2
Food seeking constrained by brief footshock	2.4	3.0	5.5	2.3	2.3	1.6	-1.3	-0.0
Seeking ratio, punishment vs. effort	1.0	1.2	2.7	0.9	0.9	0.8	-1.6	1.0
Retroperitoneal fat weight	0.2	0.5	1.1	0.8	0.8	1.1	0.5	-0.1
Reaction time number correct	0.6	0.9	2.8	0.1	0.1	-0.8	1.0	-1.7
Reaction time mean minus median	1.1	1.4	2.7	-1.2	-1.2	0.8	1.7	-0.9
Reaction time mean minus median AUC	0.5	0.7	1.5	-0.6	-0.6	0.8	1.2	-0.9
Reaction time num false alarms	0.4	0.5	1.6	-0.6	-0.5	-1.3	0.1	-0.6
Reaction time num false alarms AUC	0.7	1.0	2.2	-1.1	-1.0	-1.5	0.0	-0.7
Reaction time trials correct on left	0.6	0.9	2.8	0.1	0.1	-0.8	1.0	-1.7
Reaction time trials on left	0.6	0.9	2.7	-0.0	-0.0	-0.7	1.0	-1.6
Reaction time mean	0.7	1.0	2.8	-1.0	-1.0	0.3	1.7	-0.2
Reaction time mean AUC	0.5	0.7	2.4	-0.6	-0.7	0.5	1.6	-0.0
Median of all reaction times	0.6	0.8	2.7	-0.7	-0.8	-0.1	1.6	-0.2
Reaction time omissions	0.6	0.8	1.3	-1.0	-1.0	1.1	0.8	0.0
Reaction time false alarm rate	0.6	0.9	1.6	-1.2	-1.2	-1.2	-0.3	0.0
Reaction time premature initiation rate	0.5	0.6	1.6	0.4	0.4	0.2	-1.3	1.0
Reaction time premature initiations	0.2	0.3	0.6	0.6	0.6	0.1	-0.8	0.2
Std. dev. reaction times	1.3	1.8	3.7	-1.9	-1.9	0.3	1.3	-0.1
Reaction time trials completed	0.6	0.9	2.7	-0.0	-0.0	-0.7	1.0	-1.6
Reaction time trials AUC	0.6	0.9	2.7	-0.0	-0.0	-0.8	1.0	-1.7
Run reversals in cocaine runway, females	1.1	1.0	3.0	-0.0	-0.1	-0.5	-1.4	1.7
Run reversals in cocaine runway, males	0.3	0.3	0.8	-0.8	-0.9	-0.0	0.3	0.3
Latency to leave start box in cocaine runway	0.4	0.4	0.8	0.7	0.7	0.5	-0.9	0.1
Latency to leave start box in cocaine runway, F	0.1	0.2	0.4	0.2	0.2	0.6	0.0	-0.6
Latency to leave start box in cocaine runway, M	1.1	1.0	2.5	0.9	0.8	-0.3	-1.6	1.0
Std. dev. time between licks in bursts	1.3	1.6	3.6	0.3	0.2	-1.3	-1.6	1.9
Total sessions with >9 infusions	0.8	0.9	1.4	1.2	1.2	0.0	0.8	-0.9
Short access day 1 total inactive lever presses	0.5	0.5	0.7	-0.8	-0.8	0.8	-0.3	0.8
Short access day 10 total inactive lever presses	3.6	3.9	7.8	-1.1	-1.3	-2.0	-2.8	2.2
Short access day 1 total infusions	0.5	0.5	1.2	0.1	0.1	-1.1	0.5	-1.1
Short access day 10 total infusions	1.4	1.5	4.1	-0.1	-0.1	1.6	2.0	-0.9
Short access total infusions	1.2	1.3	3.4	-0.1	-0.0	-0.5	1.8	-1.7
Short access day 1 locomotion	0.8	0.8	1.4	-0.9	-0.9	0.5	0.9	-1.2
Short access day 10 total locomotion	1.3	1.5	5.5	-0.8	-0.8	2.4	0.8	0.1
Short access total locomotion	1.5	1.5	3.2	0.1	0.1	1.4	1.8	-1.6
One hour access (0.3 mA shock)	2.5	2.9	6.0	-0.8	-0.6	2.1	2.4	-1.8
Compulsive drug intake	2.7	2.7	5.7	-2.4	-2.3	-1.6	0.1	0.1
One hour access (shock baseline)	2.4	2.8	5.7	1.3	1.3	2.4	1.9	-1.2
Social response proportion	0.8	0.9	2.2	-0.4	-0.3	-0.2	1.5	-1.4
Social responses	0.9	1.1	5.2	0.3	0.4	2.3	0.4	-0.2
Social time	0.5	0.7	2.0	-0.3	-0.2	1.4	0.9	-0.6
Soleus weight	0.3	0.8	3.4	0.3	0.4	1.8	-0.4	-0.6
Bone: stiffness	0.2	0.3	0.9	0.3	0.3	0.9	-0.6	-0.3
Tibialis anterior weight	3.9	13.4	29.6	-5.4	-5.4	-2.6	-0.3	1.1
Time to tail flick, vehicle, before self-admin	1.2	1.2	2.4	-1.5	-1.6	-1.1	0.2	0.4
Time to tail flick, vehicle, after self-admin	0.9	1.0	2.9	-0.9	-0.9	-1.7	0.5	-0.5
Time to tail flick, test, before self-admin	0.4	0.4	2.0	-0.0	-0.1	-1.4	0.3	-0.0
Time to tail flick, test, after self-admin	1.0	1.0	2.5	-0.0	-0.1	-1.5	-1.6	0.5
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.2	1.1	1.1	0.1	-0.4	-0.3
Delta time to tail flick, test, before/after SA	0.4	0.3	0.6	-0.6	-0.6	-0.7	-0.8	-0.2
Tibia length	1.5	4.3	6.1	2.5	2.5	2.3	-2.0	0.6
Ambulatory time before self-admin	1.4	1.4	3.6	0.3	0.1	-0.6	-1.9	1.8
Ambulatory time after self-admin	0.6	0.7	1.4	-1.2	-1.2	-0.7	0.3	0.2
Bone: tissue strength	1.0	0.9	1.2	-1.1	-1.0	0.9	0.8	-1.1
Total heroin consumption	0.9	1.1	1.9	1.3	1.3	1.4	0.2	0.2
Bone: trabecular number	0.3	0.4	1.1	0.2	0.2	-1.1	-1.0	0.4
Bone: trabecular spacing	0.3	0.4	1.4	0.1	0.1	1.2	0.2	0.5
Bone: trabecular thickness	0.3	0.4	0.8	0.5	0.5	-0.9	0.2	-0.8
Bone: trabecular tissue density	8.3	11.8	23.6	4.7	4.9	3.3	-0.0	-1.4
Water consumed over 24 hours	1.2	1.5	2.8	-0.6	-0.7	1.1	-1.7	1.6
Number of responses in last shaping day	0.9	0.9	2.6	-0.3	-0.5	1.3	-0.3	1.6