Hub : Genes

Efcab7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Efcab7	0.37	0.14	1.2e-04	0.02	0.03	0.03	0.02	1.1e-03	9.8e-05	6.9e-04	1.7e-03
2	LHb	intron excision ratio	chr5_119643229_119654376	0.87	0.07	1.3e-04	0.03	0.08	0.11	0.04	5.7e-02	6.3e-03	1.8e-03	4.5e-02
3	Eye	gene expression	Efcab7	0.36	0.21	1.4e-03	0.05	0.09	0.04	0.06	6.1e-02	1.7e-02	7.6e-02	3.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.5	0.9	1.8	-0.3	-1.3	0.9
Area under the delay curve	2.5	2.9	5.2	-1.6	2.3	0.9
BMI with tail	0.5	1.9	2.6	-1.1	-1.4	-1.6
BMI without tail	1.0	3.2	4.3	-1.3	-1.9	-2.1
Body weight	0.3	1.4	1.9	-0.8	-1.4	-1.3
Weight adjusted by age	2.7	4.0	6.6	-2.6	2.1	-1.0
Bone surface	2.0	3.6	5.2	-1.7	-2.3	-1.6
Bone volume	0.9	1.7	2.8	-1.7	-1.4	-0.5
Breakpoint value in progressive ratio session	1.5	1.8	3.1	1.4	-1.8	0.6
Number of licking bursts	0.2	0.3	0.7	0.1	0.8	-0.2
Context. condit. distance diff. score	1.7	2.1	3.2	0.6	-1.7	1.8
Locomotion velocity, session 1	0.6	0.7	1.6	1.3	0.1	-0.7
Locomotion distance, session 1	1.1	1.4	1.9	1.4	1.3	0.8
Locomotion velocity, session 2	0.1	0.2	0.3	-0.4	0.6	-0.0
Locomotion distance, session 2	0.3	0.5	1.0	1.0	0.3	-0.6
Locomotion velocity, session 3	0.3	0.4	0.6	0.6	0.8	0.3
Locomotion distance, session 3	0.2	0.2	0.5	-0.3	0.7	0.1
Stereotopy head waving bouts, day 3	0.4	0.5	1.1	0.0	0.5	1.0
Stereotopy head waving duration, day 3	0.8	1.0	1.5	0.7	0.9	1.2
Locomotion velocity, session 7	0.4	0.5	1.2	0.0	-0.4	1.1
Locomotion distance, session 7	0.2	0.2	0.6	0.1	-0.3	0.8
Stereotopy head waving bouts, day 7	0.3	0.3	0.8	-0.3	0.2	-0.9
Stereotopy head waving duration, day 7	0.4	0.5	1.3	0.1	0.5	-1.2
Locomotion velocity, session 8	0.2	0.2	0.4	0.7	-0.1	0.4
Locomotion distance, session 8	0.9	1.2	2.2	1.5	-0.7	1.0
Degree of sensitization distance	0.6	0.6	1.7	-0.2	-1.3	-0.1
Degree of sensitization stereotypy	0.4	0.4	1.3	0.0	0.1	-1.1
Conditioned locomotion	0.9	1.0	2.1	1.0	1.5	0.2
Cocaine response after cond. corrected	0.4	0.5	0.8	0.4	0.9	-0.7
Cocaine response after cond. not corrected	0.3	0.3	0.5	0.7	0.2	-0.7
Cocaine response before conditioning	0.5	0.5	1.5	0.4	-1.2	-0.1
Saline control response	0.1	0.1	0.2	0.4	0.1	-0.2
Bone: connectivity density	1.8	2.8	4.7	-1.2	-2.2	-1.5
Bone: cortical apparent density	3.3	4.5	8.0	2.3	0.4	2.8
Bone: cortical area	0.4	0.6	0.7	0.7	-0.8	-0.9
Bone: cortical porosity	1.2	1.3	3.2	0.1	-1.8	-0.8
Bone: cortical porosity	0.9	1.0	1.9	0.2	-1.4	-1.0
Bone: cortical thickness	0.3	0.5	1.4	1.2	-0.2	0.3
Bone: cortical thickness	0.2	0.2	0.3	0.5	-0.5	0.3
Bone: cortical tissue density	3.3	4.5	7.9	2.4	0.4	2.8
Condit. Reinf. active minus inactive responses	0.7	0.7	1.1	1.1	-0.4	-1.0
Condit. Reinf. active-inactive response ratio	1.6	1.7	2.9	1.7	-1.4	-0.6
Condit. Reinf. active responses	0.7	0.9	2.2	0.7	-0.1	-1.5
Condit. Reinf. inactive responses	0.4	0.5	0.9	0.0	0.7	-1.0
Incentive salience index mean	1.3	1.6	3.1	1.8	-0.2	-1.2
Condit. Reinf. lever presses	1.6	2.3	6.3	2.5	-0.2	-0.8
Condit. Reinf. active minus inactive responses	0.8	1.0	2.2	1.5	-0.4	0.8
Condit. Reinf. active-inactive response ratio	1.0	1.2	3.2	1.8	-0.5	0.2
Condit. Reinf. active responses	0.8	1.1	1.8	1.0	-1.3	0.6
Condit. Reinf. inactive responses	0.5	0.6	1.2	0.3	-0.7	1.1
Condit. Reinf. lever presses	1.0	1.3	3.5	0.2	-0.6	-1.9
Condit. Reinf. lever reinforcers received	0.6	0.9	2.1	0.6	-1.5	0.2
Conditioned reinforcement - actives	0.5	0.9	2.5	1.6	-0.1	-0.1
Conditioned reinforcement - inactives	0.1	0.2	0.4	-0.4	0.6	0.3
Conditioned locomotion	1.9	2.5	7.0	2.7	-0.7	-0.1
Patch foraging indifference point 0 sec	3.3	6.2	12.6	-2.3	0.7	-3.6
Patch foraging indifference point AUC	0.4	0.6	1.9	-0.1	-0.0	-1.4
Delay disc. indifference point, 0s delay	2.1	2.3	3.5	-1.2	1.5	1.9
Delay disc. indifference point, 16s delay	1.4	1.5	1.8	-1.2	1.3	-1.2
Delay disc. indifference point, 2s delay	3.2	3.5	8.4	-2.9	1.2	0.9
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	0.5	0.7	0.2
Delay disc. indifference point, 4s delay	3.4	3.5	3.7	-1.9	1.9	1.8
Delay disc. indifference point, 8s delay	2.4	2.9	6.8	-0.5	2.6	1.2
Indifference point function ln k	0.2	0.4	0.8	0.0	-0.5	0.9
Indifference point function log k	0.2	0.4	0.8	0.0	-0.5	0.9
Patch foraging total patch changes 0 sec	3.0	5.7	12.2	-2.2	0.5	-3.5
Patch foraging total patch changes 12 sec	1.3	1.6	2.4	-0.7	1.4	-1.5
Patch foraging total patch changes 18 sec	1.4	2.1	5.7	-0.5	-0.6	-2.4
Patch foraging total patch changes 24 sec	0.7	1.3	2.7	-0.8	-0.7	-1.7
Patch foraging total patch changes 6 sec	1.6	2.5	7.3	-0.3	-0.2	-2.7
Patch foraging time to switch 0 sec	0.8	1.7	2.8	1.7	0.6	1.4
Patch foraging water rate 0 sec	0.7	1.5	2.2	-1.5	-0.1	-1.5
Patch foraging water rate 12 sec	2.4	5.1	9.6	-0.8	-3.1	-2.2
Patch foraging water rate 18 sec	0.5	0.8	1.7	0.0	-1.3	-0.8
Patch foraging water rate 24 sec	1.2	1.6	4.9	-0.1	-2.2	-0.1
Patch foraging water rate 6 sec	0.9	1.3	3.1	-0.9	-1.8	0.0
Seeking ratio, delayed vs. immediate footshock	1.9	2.4	5.7	-1.2	-2.4	-0.0
Distance traveled before self-admin	0.4	0.5	0.6	-0.5	-0.7	-0.8
Distance traveled after self-admin	0.8	0.9	1.7	-1.3	0.6	-0.9
Extensor digitorum longus weight	0.2	0.8	1.6	0.9	0.1	1.3
Bone: elastic displacement	0.4	0.5	0.7	0.6	-0.7	0.8
Bone: elastic work	0.6	0.8	1.8	0.6	0.3	1.3
Bone: endosteal estimation	1.0	2.1	3.2	-1.2	-1.8	-1.3
Bone: endosteal perimeter	0.9	1.9	3.3	-1.0	-1.2	-1.8
Epididymis fat weight	0.2	0.7	1.1	1.1	-1.0	0.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.3	-0.4	-0.0
Delta time in open arm before/after self-admin	1.6	1.6	2.3	-0.6	1.5	-1.5
Diff in mean of infusions in LGA sessions	0.4	0.4	1.1	1.0	-0.3	-0.4
Delay discount exponential model param	2.2	2.5	4.1	1.6	-2.0	-0.8
Extinction: sum of active levers before priming	1.1	1.2	2.5	-0.5	-1.6	0.9
Active lever presses in extinction session 6	1.7	1.7	4.4	0.7	-2.1	-0.4
Bone: final force	0.6	1.0	1.7	1.3	-1.0	0.5
Bone: final moment	0.5	0.7	1.3	1.0	-1.1	-0.1
Food consumed during 24 hour testing period	0.3	0.4	0.8	0.9	0.3	0.5
Glucose	0.4	0.6	1.1	0.7	-1.0	-0.5
Heart weight	2.9	4.5	7.6	1.7	-2.8	1.7
Delay discount hyperbolic model param	3.0	3.3	5.0	2.0	-2.2	-0.9
Intermittent access intake day 1-15 change	0.5	1.0	1.7	1.1	1.3	0.3
Intermittent access intake escalation	0.7	1.5	2.9	1.0	1.7	0.8
Intermittent access intake escalation 2	0.8	0.9	2.5	1.6	0.1	0.4
Intermitt. access day 1 inactive lever presses	0.6	2.1	3.1	-1.8	-1.7	-0.3
Intermitt. access day 15 inactive lever presses	0.9	1.8	2.8	1.1	-1.7	1.2
Intermitt. access escalation Index	4.1	5.7	8.8	-3.0	2.8	0.6
Intermittent access day 1 total infusions	0.4	0.6	1.0	1.0	-0.5	0.8
Intermittent access day 15 total infusions	1.5	2.2	3.1	1.5	1.7	1.2
Intermittent access terminal intake (last 3 days)	0.5	0.7	1.3	1.1	0.6	0.6
Intermittent access total infusions	1.5	1.7	3.7	1.9	0.6	1.0
Intermittent access day 1 locomotion	0.9	1.2	3.5	1.9	-0.0	-0.1
Intermittent access day 15 total locomotion	1.1	2.0	5.5	2.3	-0.3	-0.6
Intermittent access total locomotion	2.1	2.6	7.1	2.7	-0.7	-0.1
Intermittent access standard deviation	1.4	2.9	7.5	2.7	-0.9	0.6
Left kidney weight	0.2	1.2	2.4	1.0	-1.5	0.3
Right kidney weight	0.4	1.7	4.3	0.2	-2.1	0.8
Cocaine induced anxiety	4.0	5.7	16.3	-0.8	4.0	0.2
Post-drug Anxiety	4.9	5.2	11.4	-1.8	3.4	1.1
Baseline Anxiety	1.2	1.4	2.5	-1.1	-1.6	0.7
Tail length	0.1	0.5	1.3	0.4	-1.1	0.3
Length with tail	0.0	0.1	0.1	-0.1	-0.4	-0.1
Length without tail	0.0	0.1	0.1	-0.2	0.1	-0.4
Times rat made contact with spout	0.8	0.9	1.9	1.4	-0.8	-0.5
Lifetime Intake	1.4	1.7	2.4	1.6	1.2	1.0
Liver weight, left	1.4	2.3	4.4	1.2	-1.1	2.1
Liver weight, right	0.6	1.0	2.3	0.8	-0.1	1.5
Locomotor activity	0.2	0.4	0.6	-0.8	0.7	-0.3
Locomotor testing distance	1.1	1.9	2.9	-1.7	-0.0	-1.7
Locomotor testing rearing	0.0	0.1	0.1	0.2	0.2	-0.3
Locomotion in novel chamber	1.1	1.4	2.5	0.2	-1.6	-1.3
Locomotion in novel chamber post-restriction	1.6	2.5	5.3	2.3	1.4	0.5
Fecal boli incidents, locomotor time 1	1.2	1.7	3.8	1.2	2.0	0.1
Change in fecal boli incidents, locomotor task	0.3	0.3	0.7	-0.8	-0.1	0.4
Time >=10cm from walls, locomotor time 1	1.7	1.8	3.6	-1.9	1.3	-0.3
Bouts of movement, locomotor time 1	0.4	0.5	1.1	-0.1	-1.1	-0.5
Total resting periods, locomotor time 1	0.4	0.4	0.6	-0.8	-0.6	-0.5
Rest time, locomotor task time 1	0.9	1.1	3.2	-1.8	0.0	-0.5
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.2	0.2	0.4
Vertical activity count, locomotor time 1	0.2	0.4	1.1	-1.0	-0.3	0.1
Time >=10cm from walls, locomotor time 2	0.8	1.1	2.7	0.6	-0.7	1.6
Bouts of movement, locomotor time 2	0.4	0.7	1.6	-0.4	-0.5	-1.3
Total resting periods, locomotor time 2	0.3	0.6	1.5	-0.6	-0.2	-1.2
Rest time, locomotor task time 2	1.5	1.9	3.3	-1.8	1.5	-0.4
Distance moved, locomotor task time 2	2.4	2.8	5.1	1.3	-2.3	1.3
Vertical activity count, locomotor time 2	1.3	1.8	4.3	0.7	-2.1	0.7
Light reinforcement 1	1.0	2.5	6.6	1.0	-2.6	0.3
Light reinforcement 2	0.2	0.3	0.4	0.4	-0.7	0.6
Bone: marrow area	0.9	1.9	3.2	-1.0	-1.8	-1.2
Bone: maximum diameter	0.3	0.6	1.3	0.2	-0.6	-1.1
Bone: maximum force	0.7	1.2	1.9	1.3	-1.4	-0.2
Bone: maximum moment	0.8	1.4	2.6	1.0	-1.6	-0.9
Mean time between licks in bursts	1.1	2.7	8.1	0.3	0.1	2.8
Mean num. licks in bursts	0.5	0.8	1.8	0.7	-1.3	-0.3
Cd content in liver	2.0	2.3	3.4	0.8	-1.8	-1.7
Co content in liver	2.9	3.4	9.7	0.7	-3.1	-0.1
Cu content in liver	1.0	1.2	1.7	1.3	-0.9	1.0
Fe content in liver	2.4	2.9	8.8	-0.2	-3.0	0.1
K content in liver	0.8	0.8	2.1	0.3	-0.4	1.5
Mg content in liver	0.1	0.1	0.2	-0.2	-0.0	-0.4
Mn content in liver	0.5	0.6	1.2	1.1	0.6	-0.4
Na content in liver	3.0	3.2	4.8	1.1	-2.2	1.9
Rb content in liver	0.6	0.7	1.4	1.2	0.0	0.8
Se content in liver	1.3	1.6	3.4	-1.1	-1.8	-0.3
Sr content in liver	2.0	1.7	3.6	-0.3	-1.9	-1.2
Zn content in liver	0.8	0.9	1.5	1.1	-0.3	-1.2
Bone: minimum diameter	1.2	2.1	3.2	-1.5	-1.1	-1.8
Time in familiar zone, hab. session 1	1.1	1.1	2.3	0.9	-0.3	1.5
Time in novel zone, hab. session 1	2.9	2.9	5.9	-1.6	0.2	-2.4
Total zone transitions, hab. session 1	2.1	3.0	5.3	1.4	2.3	1.3
Total locomotion distance, hab. session 1	0.3	0.4	0.8	-0.4	0.9	0.6
Locomotion velocity, hab. session 1	0.5	0.7	1.6	-0.0	1.3	0.6
Time in familiar zone, hab. session 2	1.0	1.0	2.5	1.6	-0.6	0.4
Time in novel zone, hab. session 2	1.0	1.0	1.9	-1.4	0.8	-0.7
Total zone transitions, hab. session 2	4.0	5.1	7.3	1.9	2.1	2.7
Total locomotion distance, hab. session 2	2.2	2.9	4.8	0.6	1.9	2.2
Locomotion velocity, hab. session 2	1.9	2.5	4.3	0.5	1.8	2.1
Novel to familiar place preference ratio	0.7	0.7	1.3	0.0	-1.0	-1.1
Novelty place preference	0.8	0.9	1.9	-0.1	-1.4	-0.9
Time in novel zone, NPP test	1.1	1.2	2.6	-0.2	-1.6	-1.0
Total zone transitions, NPP test	1.7	2.5	2.7	1.5	1.6	1.6
Total locomotion distance, NPP test	0.6	0.9	1.3	-0.4	1.2	1.0
Locomotion velocity, NPP test	0.7	1.0	1.9	-0.2	1.4	1.0
Intraocular pressure	0.8	1.1	2.0	-1.1	1.4	0.3
Delta distance traveled before/after self-admin	0.6	0.7	1.5	-0.5	1.2	-0.6
Delta ambulatory time before/after self-admin	0.6	0.7	1.7	-0.6	1.3	-0.3
Parametrial fat weight	3.1	7.3	16.5	-2.2	-0.9	-4.1
Pavlov. Cond. lever latency	1.0	1.2	1.9	-1.3	-0.2	1.4
Pavlov. Cond. magazine entry latency	1.4	1.7	4.3	2.1	0.9	-0.0
Pavlov. Cond. change in total contacts	0.9	1.0	1.5	1.2	-0.1	-1.2
Pavlov. Cond. index score	1.1	1.4	3.2	1.8	0.5	-0.9
Pavlov. Cond. latency score	1.2	1.5	3.1	1.8	0.6	-0.9
Pavlov. Cond. lever contacts	1.0	1.2	2.6	1.6	0.2	-1.0
Pavlov. Cond. magazine entry number	1.7	2.2	6.0	-2.4	-0.7	-0.2
Pavlov. Cond. intertrial magazine entries	1.1	1.4	3.5	0.2	1.9	0.8
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.4	2.8	1.7	0.7	-1.0
Pavlov. Cond. response bias	1.4	1.7	4.8	2.2	0.1	-0.6
Pavlov. Cond. lever latency	1.3	1.8	2.9	-0.9	-1.3	1.7
Pavlov. Cond. magazine entry latency	0.8	0.9	2.5	0.3	0.4	-1.6
Pavlov. Cond. change in total contacts	0.8	1.2	2.6	-0.1	1.0	-1.6
Pavlov. Cond. index score	0.7	0.9	2.4	0.4	0.3	-1.6
Pavlov. Cond. latency score	0.6	0.8	2.1	0.5	0.3	-1.4
Pavlov. Cond. lever contacts	1.1	1.5	3.1	0.7	1.0	-1.8
Pavlov. Cond. magazine entry number	0.7	0.8	1.2	-0.5	-1.1	1.0
Pavlov. Cond. intertrial magazine entries	0.6	0.9	2.3	0.1	0.6	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.5	0.2	0.3	-1.6
Pavlov. Cond. response bias	1.1	1.4	2.7	0.7	1.0	-1.7
Time in closed arm before self-admin	0.6	0.8	1.5	0.9	1.2	0.4
Time in closed arm after self-admin	0.3	0.3	0.4	0.6	0.6	0.5
Time in open arm before self-admin	0.6	0.7	1.3	-1.1	-0.7	-0.5
Time in open arm after self-admin	2.3	2.5	3.9	-1.8	0.6	-2.0
Bone: periosteal estimation	0.8	1.7	3.0	-0.5	-1.7	-1.3
Bone: periosteal perimeter	0.7	1.2	1.8	0.6	-1.2	-1.3
Bone: post-yield work	1.8	2.7	4.0	1.2	-2.0	-1.6
Progressive ratio test 1 active lever presses	3.0	3.7	6.0	2.5	1.5	1.7
Progressive ratio test 1 breakpoint	3.2	3.9	6.3	2.5	1.4	1.8
Progressive ratio test 1 inactive lever presses	1.1	1.6	2.8	1.4	-0.3	1.7
Progressive ratio test 2 active lever presses	1.2	1.5	2.6	1.6	1.3	0.3
Progressive ratio test 2 breakpoint	1.6	1.8	3.6	1.9	1.3	0.5
Progressive ratio test 2 inactive lever presses	0.4	0.7	1.6	0.7	1.3	0.2
Incentive Sensitization - Responses	0.3	0.4	0.6	0.7	0.7	-0.4
Incentive Sensitization - Breakpoint	0.3	0.4	0.5	0.6	0.7	-0.6
Sum of active levers in priming session hrs 5-6	2.7	2.5	6.1	-1.0	-2.5	0.7
Progressive ratio	0.3	0.5	1.3	1.1	0.1	0.5
Food seeking constrained by brief footshock	2.2	2.7	5.4	1.3	1.0	2.3
Seeking ratio, punishment vs. effort	0.3	0.5	0.9	0.7	-0.3	0.9
Retroperitoneal fat weight	0.2	0.7	1.8	-0.5	0.1	-1.4
Reaction time number correct	0.5	1.0	2.7	-0.5	1.6	-0.0
Reaction time mean minus median	0.3	0.8	1.5	1.0	-0.3	-1.2
Reaction time mean minus median AUC	0.2	0.4	0.7	0.9	-0.2	-0.6
Reaction time num false alarms	0.4	0.6	1.3	-0.6	1.1	-0.5
Reaction time num false alarms AUC	0.7	1.1	1.4	-0.8	1.2	-1.1
Reaction time trials correct on left	0.5	1.0	2.7	-0.5	1.6	-0.0
Reaction time trials on left	0.5	1.0	2.7	-0.5	1.6	-0.1
Reaction time mean	0.2	0.4	1.0	0.3	0.3	-1.0
Reaction time mean AUC	0.1	0.2	0.5	0.3	0.2	-0.7
Median of all reaction times	0.2	0.3	0.7	-0.1	0.5	-0.8
Reaction time omissions	0.8	1.2	1.8	1.3	-0.3	-1.3
Reaction time false alarm rate	0.5	0.6	1.4	-0.7	0.2	-1.2
Reaction time premature initiation rate	0.9	1.2	3.2	-0.3	-1.8	0.5
Reaction time premature initiations	0.2	0.3	0.4	-0.2	-0.7	0.6
Std. dev. reaction times	0.7	1.3	3.8	0.3	-0.3	-1.9
Reaction time trials completed	0.5	1.0	2.7	-0.5	1.6	-0.1
Reaction time trials AUC	0.5	1.0	2.9	-0.5	1.7	-0.1
Run reversals in cocaine runway, females	0.2	0.2	0.3	-0.5	-0.5	0.1
Run reversals in cocaine runway, males	0.3	0.3	0.9	-0.2	0.2	-1.0
Latency to leave start box in cocaine runway	0.1	0.2	0.3	0.3	-0.3	0.5
Latency to leave start box in cocaine runway, F	0.0	0.1	0.1	0.2	0.0	-0.4
Latency to leave start box in cocaine runway, M	0.4	0.4	1.0	-0.2	-0.4	1.0
Std. dev. time between licks in bursts	1.0	1.4	4.0	-2.0	-0.2	0.2
Total sessions with >9 infusions	2.2	2.7	5.9	0.9	2.4	1.1
Short access day 1 total inactive lever presses	1.0	1.3	3.3	0.7	-1.8	0.3
Short access day 10 total inactive lever presses	2.2	5.3	7.2	-2.6	-2.7	-1.3
Short access day 1 total infusions	0.4	0.5	0.6	-0.7	0.8	0.7
Short access day 10 total infusions	2.2	2.8	7.5	2.7	-0.4	0.9
Short access total infusions	0.9	1.2	1.9	1.1	1.4	0.7
Short access day 1 locomotion	0.4	0.4	1.3	1.1	-0.1	-0.1
Short access day 10 total locomotion	1.7	3.2	6.2	2.5	-1.6	-0.8
Short access total locomotion	1.4	1.6	4.6	2.2	0.4	0.3
One hour access (0.3 mA shock)	2.8	3.2	9.4	3.1	-0.5	-0.4
Compulsive drug intake	2.5	2.9	4.7	-2.2	0.9	-1.8
One hour access (shock baseline)	2.2	3.4	8.5	2.9	-0.1	1.3
Social response proportion	0.2	0.2	0.3	0.4	0.5	-0.5
Social responses	2.0	2.6	6.3	2.5	-1.2	0.4
Social time	1.2	1.6	4.3	2.1	0.8	-0.3
Soleus weight	0.5	1.6	4.3	2.1	-0.7	0.1
Bone: stiffness	0.5	0.8	1.7	0.8	-1.3	-0.2
Tibialis anterior weight	3.6	12.4	29.1	-2.7	-0.9	-5.4
Time to tail flick, vehicle, before self-admin	0.9	1.0	2.3	-0.7	0.4	-1.5
Time to tail flick, vehicle, after self-admin	1.7	2.3	3.9	-1.4	2.0	-0.9
Time to tail flick, test, before self-admin	0.8	0.9	2.5	-1.6	0.0	0.3
Time to tail flick, test, after self-admin	0.5	0.5	0.7	-0.8	-0.8	0.6
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.8	-0.1	0.2	0.9
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	-0.2	-0.1	-0.5
Tibia length	1.6	4.4	7.1	2.1	-1.3	2.7
Ambulatory time before self-admin	0.5	0.7	1.4	-0.8	-1.2	-0.4
Ambulatory time after self-admin	0.3	0.4	0.9	-0.5	0.1	-0.9
Bone: tissue strength	0.8	0.8	1.9	1.4	0.3	-0.7
Total heroin consumption	1.1	1.3	1.8	1.0	-1.3	1.0
Bone: trabecular number	0.2	0.4	0.5	-0.7	-0.6	0.5
Bone: trabecular spacing	0.2	0.3	0.6	0.8	-0.4	0.0
Bone: trabecular thickness	0.2	0.2	0.4	-0.2	0.4	0.6
Bone: trabecular tissue density	7.2	10.6	20.5	3.2	1.1	4.5
Water consumed over 24 hours	0.5	0.7	1.1	1.1	-1.0	-0.4
Number of responses in last shaping day	0.6	0.7	1.6	0.6	-1.3	-0.2