Hub : Genes

Krt80

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative TSS NM_001008815.2 0.03 0.02 2.0e-04 0.04 0.03 0.03 0.04 1.0e-05 2.7e-04 3.0e-04 8.6e-05
2 Adipose alternative TSS XM_063263678.1 0.03 0.02 3.3e-04 0.04 0.03 0.03 0.03 1.5e-05 4.5e-04 7.1e-04 9.5e-05
3 Adipose isoform ratio NM_001008815.2 0.03 0.02 1.4e-04 0.03 0.03 0.03 0.03 2.2e-04 2.4e-04 7.1e-04 2.6e-04
4 Adipose isoform ratio XM_063263678.1 0.03 0.02 2.0e-04 0.04 0.03 0.02 0.03 4.6e-05 3.6e-04 8.7e-04 1.7e-04
5 Adipose mRNA stability Krt80 0.14 0.09 5.6e-17 0.14 0.14 0.12 0.13 5.3e-15 7.6e-15 2.2e-13 1.4e-14
6 Adipose gene expression Krt80 0.09 0.06 5.7e-07 0.04 0.04 0.03 0.04 7.7e-05 9.4e-06 3.3e-04 3.4e-05
7 PL gene expression Krt80 0.06 0.03 3.3e-09 0.07 0.08 0.06 0.08 3.2e-08 3.7e-09 1.2e-06 7.3e-09
8 BLA gene expression Krt80 0.1 0.11 1.1e-03 0.01 0.07 0 0.02 1.5e-01 2.0e-04 2.0e-01 2.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.10.20.5-0.50.5-0.50.5-0.30.30.40.7
Area under the delay curve0.20.21.3-0.10.1-0.10.1-0.20.20.31.1
BMI with tail1.55.36.3-2.52.5-2.52.5-2.52.42.40.9
BMI without tail0.41.32.7-0.90.9-0.90.9-1.61.41.40.3
Body weight0.20.92.2-0.50.5-0.50.5-1.51.21.40.6
Weight adjusted by age1.11.63.3-1.11.1-1.11.1-1.60.61.51.8
Bone surface0.40.81.3-1.11.1-1.11.1-0.50.70.6-0.1
Bone volume0.50.91.2-1.11.1-1.11.1-0.81.00.80.2
Breakpoint value in progressive ratio session0.60.81.6-1.01.0-1.01.0-0.70.4-0.0-1.3
Number of licking bursts0.10.10.7-0.20.2-0.20.2-0.20.40.2-0.9
Context. condit. distance diff. score0.40.43.30.1-0.10.1-0.10.20.3-0.2-1.8
Locomotion velocity, session 13.84.14.82.2-2.22.2-2.21.9-2.0-1.7-1.8
Locomotion distance, session 10.60.70.90.9-0.90.9-0.90.7-0.9-0.6-0.9
Locomotion velocity, session 22.63.04.11.9-1.91.9-1.91.6-2.0-1.4-0.4
Locomotion distance, session 20.60.91.20.9-0.90.9-0.91.0-1.1-0.9-0.9
Locomotion velocity, session 34.95.66.22.5-2.52.5-2.52.4-2.4-2.2-2.0
Locomotion distance, session 34.34.76.22.1-2.12.1-2.12.5-2.3-2.2-1.8
Stereotopy head waving bouts, day 32.22.63.3-1.81.8-1.81.8-1.51.71.50.2
Stereotopy head waving duration, day 30.20.20.6-0.50.5-0.50.5-0.20.50.3-0.8
Locomotion velocity, session 70.91.03.80.5-0.50.5-0.51.2-0.6-1.2-1.9
Locomotion distance, session 72.93.64.51.8-1.81.8-1.82.1-2.0-2.1-1.8
Stereotopy head waving bouts, day 74.34.85.6-2.32.3-2.32.3-2.22.42.31.5
Stereotopy head waving duration, day 72.32.73.4-1.71.7-1.71.7-1.71.81.80.9
Locomotion velocity, session 80.30.42.50.3-0.30.3-0.30.5-0.0-0.3-1.6
Locomotion distance, session 81.62.34.01.5-1.51.5-1.51.5-1.3-1.4-2.0
Degree of sensitization distance0.40.40.7-0.60.6-0.60.6-0.80.80.70.3
Degree of sensitization stereotypy2.62.93.4-1.71.7-1.71.7-1.71.81.81.5
Conditioned locomotion0.50.64.20.2-0.20.2-0.20.4-0.3-0.5-2.1
Cocaine response after cond. corrected0.10.20.4-0.20.2-0.20.2-0.60.20.50.6
Cocaine response after cond. not corrected0.00.00.10.1-0.10.1-0.1-0.3-0.10.20.3
Cocaine response before conditioning1.11.42.81.0-1.01.0-1.01.3-0.9-1.3-1.7
Saline control response0.10.21.4-0.00.0-0.00.00.30.1-0.3-1.2
Bone: connectivity density0.10.20.3-0.40.4-0.40.40.5-0.4-0.40.1
Bone: cortical apparent density1.72.42.9-1.51.5-1.51.5-1.71.61.71.2
Bone: cortical area0.71.01.2-1.11.1-1.11.1-1.10.90.90.8
Bone: cortical porosity1.41.51.61.3-1.31.3-1.31.2-1.2-1.2-1.3
Bone: cortical porosity1.61.71.91.4-1.41.4-1.41.2-1.2-1.2-1.3
Bone: cortical thickness0.40.71.2-0.90.9-0.90.9-0.80.50.71.1
Bone: cortical thickness0.60.71.40.8-0.80.8-0.80.7-1.2-0.70.7
Bone: cortical tissue density1.62.12.7-1.41.4-1.41.4-1.61.51.61.1
Condit. Reinf. active minus inactive responses0.10.10.20.3-0.30.3-0.30.2-0.4-0.3-0.3
Condit. Reinf. active-inactive response ratio0.20.20.60.4-0.40.4-0.40.4-0.8-0.60.1
Condit. Reinf. active responses0.30.40.60.7-0.70.7-0.70.5-0.8-0.5-0.4
Condit. Reinf. inactive responses0.40.50.70.8-0.80.8-0.80.6-0.6-0.4-0.7
Incentive salience index mean0.00.00.1-0.00.0-0.00.0-0.2-0.10.10.3
Condit. Reinf. lever presses0.50.71.0-0.70.7-0.70.7-1.00.80.90.8
Condit. Reinf. active minus inactive responses1.41.82.3-1.51.5-1.51.5-1.31.21.10.6
Condit. Reinf. active-inactive response ratio0.30.30.7-0.50.5-0.50.5-0.80.60.60.5
Condit. Reinf. active responses1.72.33.4-1.91.9-1.91.9-1.21.51.10.0
Condit. Reinf. inactive responses0.50.71.0-1.01.0-1.01.0-0.30.60.4-0.7
Condit. Reinf. lever presses0.40.52.40.4-0.40.4-0.40.7-0.5-0.9-1.5
Condit. Reinf. lever reinforcers received0.81.11.7-1.31.3-1.31.3-0.70.90.5-0.5
Conditioned reinforcement - actives0.20.30.90.4-0.40.4-0.40.90.1-0.4-0.7
Conditioned reinforcement - inactives0.20.20.60.3-0.30.3-0.30.6-0.6-0.8-0.4
Conditioned locomotion0.30.41.00.5-0.50.5-0.51.0-0.2-0.8-0.9
Patch foraging indifference point 0 sec0.30.51.10.6-0.60.6-0.60.7-0.5-0.8-1.0
Patch foraging indifference point AUC0.20.30.4-0.50.5-0.50.5-0.60.70.60.3
Delay disc. indifference point, 0s delay0.20.21.5-0.10.1-0.10.1-0.2-0.10.11.2
Delay disc. indifference point, 16s delay0.10.10.6-0.10.1-0.10.1-0.30.10.10.7
Delay disc. indifference point, 2s delay5.76.36.9-2.52.5-2.52.5-2.52.62.62.2
Delay disc. indifference point, 24s delay0.10.10.20.4-0.40.4-0.40.10.20.10.2
Delay disc. indifference point, 4s delay0.50.53.0-0.40.4-0.40.4-0.40.40.31.7
Delay disc. indifference point, 8s delay0.40.50.70.8-0.80.8-0.80.6-0.5-0.50.1
Indifference point function ln k0.00.00.10.1-0.10.1-0.10.0-0.10.1-0.3
Indifference point function log k0.00.00.10.1-0.10.1-0.10.0-0.10.1-0.3
Patch foraging total patch changes 0 sec0.61.21.81.0-1.01.0-1.01.1-0.9-1.2-1.3
Patch foraging total patch changes 12 sec0.10.10.50.3-0.30.3-0.30.30.1-0.3-0.7
Patch foraging total patch changes 18 sec0.20.31.10.4-0.40.4-0.40.6-0.3-0.6-1.1
Patch foraging total patch changes 24 sec0.00.10.30.0-0.00.0-0.00.30.1-0.3-0.6
Patch foraging total patch changes 6 sec0.00.10.20.0-0.00.0-0.00.30.0-0.3-0.5
Patch foraging time to switch 0 sec0.20.41.1-0.40.4-0.40.4-0.80.40.51.0
Patch foraging water rate 0 sec0.10.20.80.4-0.40.4-0.40.10.0-0.1-0.9
Patch foraging water rate 12 sec0.71.53.51.2-1.21.2-1.20.8-0.9-0.9-1.9
Patch foraging water rate 18 sec0.10.10.80.2-0.20.2-0.2-0.00.1-0.1-0.9
Patch foraging water rate 24 sec0.20.30.9-0.40.4-0.40.4-0.50.80.5-0.9
Patch foraging water rate 6 sec0.71.01.51.2-1.21.2-1.20.7-0.4-0.5-1.0
Seeking ratio, delayed vs. immediate footshock0.00.00.1-0.00.0-0.00.0-0.2-0.2-0.1-0.3
Distance traveled before self-admin0.10.20.40.5-0.50.5-0.50.4-0.2-0.30.6
Distance traveled after self-admin3.44.25.32.3-2.32.3-2.32.3-1.4-2.0-1.4
Extensor digitorum longus weight6.224.431.5-4.74.7-4.74.7-5.65.45.63.9
Bone: elastic displacement5.05.88.62.4-2.42.4-2.42.3-2.0-2.3-2.9
Bone: elastic work2.83.64.32.1-2.12.1-2.11.7-2.1-1.9-1.0
Bone: endosteal estimation0.10.30.5-0.50.5-0.50.5-0.50.70.5-0.4
Bone: endosteal perimeter0.40.91.3-0.90.9-0.90.9-1.21.11.00.4
Epididymis fat weight3.010.112.03.5-3.53.5-3.52.9-3.3-3.1-2.1
Delta time in closed arm before/after self-admin0.40.30.5-0.70.7-0.70.70.60.2-0.2-0.3
Delta time in open arm before/after self-admin3.53.54.32.0-2.02.0-2.01.4-2.1-1.8-1.3
Diff in mean of infusions in LGA sessions0.91.11.4-1.21.2-1.21.2-0.90.81.00.7
Delay discount exponential model param0.30.31.80.1-0.10.1-0.10.3-0.4-0.4-1.3
Extinction: sum of active levers before priming1.71.92.6-1.61.6-1.61.6-1.51.01.10.7
Active lever presses in extinction session 60.10.10.3-0.00.0-0.00.0-0.1-0.3-0.6-0.3
Bone: final force0.20.30.4-0.60.6-0.60.6-0.60.30.40.6
Bone: final moment0.10.20.3-0.60.6-0.60.6-0.60.40.30.3
Food consumed during 24 hour testing period0.91.23.11.0-1.01.0-1.00.9-0.8-1.0-1.8
Glucose0.20.30.70.3-0.30.3-0.30.7-0.6-0.5-0.8
Heart weight0.10.10.4-0.00.0-0.00.00.4-0.6-0.6-0.3
Delay discount hyperbolic model param0.40.52.40.4-0.40.4-0.40.6-0.6-0.6-1.5
Intermittent access intake day 1-15 change0.61.22.81.1-1.11.1-1.10.6-0.7-1.1-1.7
Intermittent access intake escalation0.20.41.00.6-0.60.6-0.60.2-0.4-0.6-1.0
Intermittent access intake escalation 20.30.30.80.5-0.50.5-0.50.9-0.6-0.8-0.3
Intermitt. access day 1 inactive lever presses0.31.01.5-1.21.2-1.21.2-0.60.90.60.7
Intermitt. access day 15 inactive lever presses0.00.00.0-0.10.1-0.10.1-0.0-0.2-0.2-0.1
Intermitt. access escalation Index1.92.73.1-1.81.8-1.81.8-1.41.61.41.7
Intermittent access day 1 total infusions0.00.10.2-0.10.1-0.10.10.40.1-0.3-0.5
Intermittent access day 15 total infusions0.10.21.30.2-0.20.2-0.2-0.00.0-0.4-1.2
Intermittent access terminal intake (last 3 days)0.10.10.9-0.10.1-0.10.10.10.3-0.3-0.9
Intermittent access total infusions0.20.20.4-0.50.5-0.50.50.10.5-0.2-0.6
Intermittent access day 1 locomotion0.20.31.00.3-0.30.3-0.30.5-0.0-0.7-1.0
Intermittent access day 15 total locomotion1.62.83.71.7-1.71.7-1.71.5-1.5-1.9-1.7
Intermittent access total locomotion0.70.91.50.8-0.80.8-0.81.2-0.5-1.2-1.2
Intermittent access standard deviation0.61.32.41.0-1.01.0-1.01.3-1.4-1.5-0.6
Left kidney weight0.10.41.90.3-0.30.3-0.3-0.50.10.61.4
Right kidney weight0.31.26.40.0-0.00.0-0.0-1.20.41.22.5
Cocaine induced anxiety0.30.51.40.5-0.50.5-0.51.2-0.1-0.2-1.2
Post-drug Anxiety0.70.82.30.8-0.80.8-0.81.0-0.3-0.6-1.5
Baseline Anxiety0.20.31.3-0.30.3-0.30.3-1.2-0.10.20.4
Tail length0.62.33.92.0-2.02.0-2.00.9-0.8-0.8-0.9
Length with tail0.41.73.21.8-1.81.8-1.80.3-0.5-0.2-0.1
Length without tail0.00.10.30.5-0.50.5-0.5-0.10.00.2-0.1
Times rat made contact with spout0.80.91.30.9-0.90.9-0.90.8-0.8-0.9-1.1
Lifetime Intake0.20.20.7-0.30.3-0.30.30.50.2-0.6-0.9
Liver weight, left0.00.00.10.0-0.00.0-0.0-0.10.30.20.1
Liver weight, right0.10.20.40.5-0.50.5-0.50.1-0.3-0.20.7
Locomotor activity0.10.10.40.3-0.30.3-0.30.6-0.3-0.40.0
Locomotor testing distance0.30.60.90.7-0.70.7-0.70.9-0.6-0.9-0.8
Locomotor testing rearing0.40.71.10.9-0.90.9-0.91.0-0.8-0.9-0.1
Locomotion in novel chamber0.91.22.1-1.01.0-1.01.0-0.71.51.30.8
Locomotion in novel chamber post-restriction0.50.71.4-1.21.2-1.21.20.40.5-0.30.0
Fecal boli incidents, locomotor time 12.43.54.02.0-2.02.0-2.01.6-2.0-1.9-1.4
Change in fecal boli incidents, locomotor task0.90.91.8-0.90.9-0.90.9-1.40.90.90.1
Time >=10cm from walls, locomotor time 11.01.14.20.8-0.80.8-0.80.9-0.6-0.8-2.1
Bouts of movement, locomotor time 10.20.20.60.4-0.40.4-0.40.1-0.6-0.30.8
Total resting periods, locomotor time 10.50.61.20.9-0.90.9-0.90.2-1.1-0.70.4
Rest time, locomotor task time 10.60.81.11.1-1.11.1-1.10.4-0.9-0.7-0.1
Distance moved, locomotor task time 10.91.32.0-1.41.4-1.41.4-0.31.30.8-0.0
Vertical activity count, locomotor time 11.02.42.8-1.71.7-1.71.7-1.01.71.51.4
Time >=10cm from walls, locomotor time 20.20.30.40.6-0.60.6-0.60.6-0.5-0.6-0.3
Bouts of movement, locomotor time 21.42.32.8-1.71.7-1.71.7-1.31.51.30.9
Total resting periods, locomotor time 21.83.23.9-2.02.0-2.02.0-1.71.81.61.2
Rest time, locomotor task time 20.10.20.40.4-0.40.4-0.4-0.6-0.2-0.1-0.5
Distance moved, locomotor task time 20.10.10.6-0.20.2-0.20.20.10.10.20.7
Vertical activity count, locomotor time 20.40.62.8-0.70.7-0.70.70.20.30.51.7
Light reinforcement 10.00.10.1-0.30.3-0.30.3-0.00.1-0.00.3
Light reinforcement 20.00.10.30.1-0.10.1-0.1-0.1-0.30.10.6
Bone: marrow area0.10.20.5-0.40.4-0.40.4-0.40.70.4-0.4
Bone: maximum diameter0.30.70.9-0.90.9-0.90.9-0.90.90.8-0.1
Bone: maximum force0.71.31.5-1.21.2-1.21.2-1.21.01.10.9
Bone: maximum moment0.61.01.2-1.11.1-1.11.1-1.11.00.90.6
Mean time between licks in bursts0.51.11.71.0-1.01.0-1.01.3-1.0-1.2-0.9
Mean num. licks in bursts0.61.01.41.0-1.01.0-1.01.0-1.2-1.1-0.2
Cd content in liver0.50.52.10.6-0.60.6-0.60.5-0.4-0.6-1.4
Co content in liver0.20.20.3-0.50.5-0.50.5-0.30.50.4-0.2
Cu content in liver0.20.20.4-0.50.5-0.50.50.00.6-0.0-0.2
Fe content in liver0.10.20.20.5-0.50.5-0.50.4-0.1-0.4-0.3
K content in liver0.10.10.6-0.00.0-0.00.0-0.1-0.00.10.7
Mg content in liver0.40.40.60.7-0.70.7-0.70.5-0.4-0.6-0.8
Mn content in liver0.00.00.1-0.10.1-0.10.1-0.20.10.30.2
Na content in liver0.10.10.3-0.50.5-0.50.50.2-0.0-0.1-0.1
Rb content in liver0.40.52.30.4-0.40.4-0.40.80.0-0.7-1.5
Se content in liver1.51.82.81.7-1.71.7-1.70.9-1.0-1.0-0.3
Sr content in liver0.10.10.5-0.10.1-0.10.10.4-0.7-0.40.0
Zn content in liver1.21.31.41.2-1.21.2-1.21.0-1.0-1.1-1.2
Bone: minimum diameter0.71.31.6-1.21.2-1.21.2-1.21.11.10.6
Time in familiar zone, hab. session 10.40.40.60.7-0.70.7-0.70.6-0.8-0.40.3
Time in novel zone, hab. session 11.71.72.5-1.41.4-1.41.4-1.41.61.2-0.1
Total zone transitions, hab. session 10.91.31.5-1.21.2-1.21.2-0.80.91.11.2
Total locomotion distance, hab. session 10.10.20.40.4-0.40.4-0.40.5-0.6-0.30.1
Locomotion velocity, hab. session 10.20.30.50.5-0.50.5-0.50.6-0.7-0.40.2
Time in familiar zone, hab. session 20.10.10.30.1-0.10.1-0.10.5-0.4-0.4-0.6
Time in novel zone, hab. session 20.40.40.9-0.60.6-0.60.6-0.90.90.80.3
Total zone transitions, hab. session 20.10.10.30.3-0.30.3-0.30.5-0.6-0.30.3
Total locomotion distance, hab. session 20.20.30.80.4-0.40.4-0.40.5-0.9-0.50.2
Locomotion velocity, hab. session 20.40.51.30.6-0.60.6-0.60.7-1.2-0.60.2
Novel to familiar place preference ratio1.21.32.3-0.90.9-0.90.9-1.21.01.31.5
Novelty place preference0.80.81.6-0.70.7-0.70.7-1.00.91.11.3
Time in novel zone, NPP test0.91.01.5-0.90.9-0.90.9-1.11.01.21.2
Total zone transitions, NPP test0.30.50.80.7-0.70.7-0.70.8-0.9-0.50.3
Total locomotion distance, NPP test1.52.03.51.5-1.51.5-1.51.3-1.9-1.20.4
Locomotion velocity, NPP test1.82.54.31.7-1.71.7-1.71.5-2.1-1.30.5
Intraocular pressure1.62.311.70.8-0.80.8-0.81.2-0.4-1.4-3.4
Delta distance traveled before/after self-admin6.16.57.42.7-2.72.7-2.72.5-2.1-2.5-2.4
Delta ambulatory time before/after self-admin4.65.66.32.5-2.52.5-2.52.5-1.9-2.3-2.2
Parametrial fat weight1.63.76.21.9-1.91.9-1.91.9-1.3-1.9-2.5
Pavlov. Cond. lever latency1.31.62.21.4-1.41.4-1.41.1-1.5-1.2-0.5
Pavlov. Cond. magazine entry latency2.02.53.4-1.51.5-1.51.5-1.71.81.71.1
Pavlov. Cond. change in total contacts3.13.34.1-1.91.9-1.91.9-1.82.01.91.2
Pavlov. Cond. index score3.34.25.4-2.12.1-2.12.1-2.12.32.11.6
Pavlov. Cond. latency score3.13.95.3-2.02.0-2.02.0-1.92.32.01.3
Pavlov. Cond. lever contacts1.31.62.2-1.31.3-1.31.3-1.11.51.20.7
Pavlov. Cond. magazine entry number1.62.02.41.5-1.51.5-1.51.4-1.6-1.4-0.8
Pavlov. Cond. intertrial magazine entries1.92.33.41.4-1.41.4-1.41.6-1.4-1.5-1.9
Pavlov. Cond. lever-magazine prob. diff.3.34.15.1-2.12.1-2.12.1-2.02.32.11.5
Pavlov. Cond. response bias0.91.11.5-1.11.1-1.11.1-1.11.21.10.5
Pavlov. Cond. lever latency1.31.72.5-1.21.2-1.21.2-1.21.21.41.6
Pavlov. Cond. magazine entry latency2.02.53.81.6-1.61.6-1.61.6-2.0-1.6-0.6
Pavlov. Cond. change in total contacts0.71.11.6-1.11.1-1.11.1-1.21.11.00.3
Pavlov. Cond. index score1.31.72.01.4-1.41.4-1.41.2-1.4-1.3-1.0
Pavlov. Cond. latency score1.21.52.01.3-1.31.3-1.31.2-1.4-1.3-0.8
Pavlov. Cond. lever contacts1.92.63.41.6-1.61.6-1.61.4-1.5-1.6-1.9
Pavlov. Cond. magazine entry number0.60.71.1-0.80.8-0.80.8-0.91.00.90.6
Pavlov. Cond. intertrial magazine entries1.32.04.61.3-1.31.3-1.31.2-1.0-1.3-2.1
Pavlov. Cond. lever-magazine prob. diff.0.81.11.51.1-1.11.1-1.10.9-1.2-1.1-0.7
Pavlov. Cond. response bias1.62.12.91.4-1.41.4-1.41.4-1.5-1.6-1.7
Time in closed arm before self-admin1.62.03.3-1.01.0-1.01.0-1.81.41.81.8
Time in closed arm after self-admin3.63.85.0-2.22.2-2.22.2-1.42.01.71.4
Time in open arm before self-admin0.60.61.3-0.80.8-0.80.8-0.61.10.80.4
Time in open arm after self-admin1.11.32.01.4-1.41.4-1.40.5-1.0-0.7-0.6
Bone: periosteal estimation0.40.81.1-0.90.9-0.90.9-1.01.00.90.3
Bone: periosteal perimeter1.22.12.9-1.41.4-1.41.4-1.71.61.60.8
Bone: post-yield work0.30.50.7-0.80.8-0.80.8-0.50.70.4-0.1
Progressive ratio test 1 active lever presses0.91.22.91.0-1.01.0-1.00.8-0.5-1.2-1.7
Progressive ratio test 1 breakpoint1.21.53.71.1-1.11.1-1.11.0-0.6-1.3-1.9
Progressive ratio test 1 inactive lever presses0.40.61.0-0.90.9-0.90.9-0.70.70.31.0
Progressive ratio test 2 active lever presses0.10.10.7-0.20.2-0.20.2-0.10.5-0.2-0.8
Progressive ratio test 2 breakpoint0.20.20.5-0.40.4-0.40.4-0.30.70.0-0.6
Progressive ratio test 2 inactive lever presses0.10.20.60.3-0.30.3-0.30.3-0.1-0.7-0.7
Incentive Sensitization - Responses0.40.61.0-0.80.8-0.80.8-0.81.00.80.3
Incentive Sensitization - Breakpoint0.70.91.3-1.01.0-1.01.0-1.01.20.90.5
Sum of active levers in priming session hrs 5-60.70.71.3-1.01.0-1.01.0-1.10.40.40.4
Progressive ratio0.00.00.2-0.00.0-0.00.00.10.1-0.2-0.4
Food seeking constrained by brief footshock0.10.10.50.0-0.00.0-0.00.70.1-0.50.4
Seeking ratio, punishment vs. effort0.00.00.3-0.10.1-0.10.10.10.0-0.10.5
Retroperitoneal fat weight3.414.316.24.0-4.04.0-4.03.4-3.3-3.7-3.7
Reaction time number correct1.42.64.11.9-1.91.9-1.90.6-1.0-0.9-2.0
Reaction time mean minus median0.00.10.4-0.20.2-0.20.2-0.10.10.00.7
Reaction time mean minus median AUC0.10.20.8-0.30.3-0.30.3-0.30.40.30.9
Reaction time num false alarms0.20.30.60.6-0.60.6-0.60.4-0.5-0.3-0.8
Reaction time num false alarms AUC0.10.10.20.4-0.40.4-0.40.1-0.3-0.0-0.2
Reaction time trials correct on left1.42.64.11.9-1.91.9-1.90.6-1.0-0.9-2.0
Reaction time trials on left1.42.73.92.0-2.02.0-2.00.6-1.0-0.9-2.0
Reaction time mean0.10.20.2-0.40.4-0.40.4-0.40.50.20.3
Reaction time mean AUC0.10.10.2-0.30.3-0.30.3-0.40.50.30.4
Median of all reaction times0.10.10.1-0.30.3-0.30.3-0.40.40.20.1
Reaction time omissions0.60.91.71.0-1.01.0-1.00.7-1.0-0.61.3
Reaction time false alarm rate0.40.60.8-0.90.9-0.90.9-0.40.60.70.8
Reaction time premature initiation rate1.31.83.21.3-1.31.3-1.31.8-1.0-1.4-1.1
Reaction time premature initiations2.44.25.22.3-2.32.3-2.32.0-1.5-1.8-1.9
Std. dev. reaction times0.20.30.8-0.60.6-0.60.6-0.30.30.20.9
Reaction time trials completed1.42.73.92.0-2.02.0-2.00.6-1.0-0.9-2.0
Reaction time trials AUC1.22.33.41.8-1.81.8-1.80.5-0.9-0.8-1.8
Run reversals in cocaine runway, females0.40.40.70.9-0.90.9-0.9-0.4-0.3-0.1-0.2
Run reversals in cocaine runway, males2.22.24.3-1.31.3-1.31.3-1.71.01.52.1
Latency to leave start box in cocaine runway0.20.20.3-0.40.4-0.40.4-0.50.50.50.2
Latency to leave start box in cocaine runway, F0.20.20.5-0.40.4-0.40.4-0.70.50.50.4
Latency to leave start box in cocaine runway, M0.10.10.2-0.30.3-0.30.3-0.20.40.3-0.1
Std. dev. time between licks in bursts1.31.72.21.5-1.51.5-1.51.2-1.4-1.3-0.6
Total sessions with >9 infusions0.10.20.3-0.50.5-0.50.5-0.20.4-0.2-0.2
Short access day 1 total inactive lever presses0.10.10.20.3-0.30.3-0.30.4-0.1-0.5-0.0
Short access day 10 total inactive lever presses0.10.30.5-0.70.7-0.70.7-0.20.50.30.6
Short access day 1 total infusions0.20.30.60.5-0.50.5-0.50.6-0.2-0.8-0.5
Short access day 10 total infusions0.50.61.1-1.11.1-1.11.1-0.20.5-0.0-0.4
Short access total infusions0.20.30.9-0.10.1-0.10.10.8-0.1-0.9-0.9
Short access day 1 locomotion0.00.00.10.0-0.00.0-0.0-0.30.1-0.10.2
Short access day 10 total locomotion0.10.20.4-0.60.6-0.60.6-0.10.3-0.0-0.0
Short access total locomotion0.10.10.2-0.40.4-0.40.4-0.30.3-0.20.0
One hour access (0.3 mA shock)0.60.71.3-0.90.9-0.90.9-0.31.10.60.4
Compulsive drug intake0.80.91.4-1.21.2-1.21.2-0.21.20.80.2
One hour access (shock baseline)0.10.10.3-0.40.4-0.40.4-0.40.60.30.2
Social response proportion1.71.92.71.4-1.41.4-1.41.6-1.5-1.30.3
Social responses0.60.82.90.6-0.60.6-0.60.8-0.9-0.41.7
Social time0.91.22.60.9-0.90.9-0.91.3-1.6-1.00.8
Soleus weight0.10.20.40.6-0.60.6-0.60.0-0.2-0.00.3
Bone: stiffness2.54.04.4-2.12.1-2.12.1-2.11.81.91.9
Tibialis anterior weight8.930.339.7-5.45.4-5.45.4-6.36.26.23.3
Time to tail flick, vehicle, before self-admin0.60.72.5-0.80.8-0.80.8-0.10.30.11.6
Time to tail flick, vehicle, after self-admin0.10.20.6-0.30.3-0.30.3-0.50.30.80.3
Time to tail flick, test, before self-admin0.50.62.6-0.50.5-0.50.5-0.60.30.71.6
Time to tail flick, test, after self-admin1.11.11.6-1.31.3-1.31.3-0.80.60.80.9
Delta time to tail flick, vehicle, before/after SA0.40.41.70.5-0.50.5-0.50.3-0.3-0.1-1.3
Delta time to tail flick, test, before/after SA0.10.10.2-0.40.4-0.40.4-0.20.20.1-0.2
Tibia length0.10.32.20.1-0.10.1-0.10.10.2-0.2-1.5
Ambulatory time before self-admin0.10.10.40.2-0.20.2-0.20.4-0.4-0.60.0
Ambulatory time after self-admin3.23.74.72.0-2.02.0-2.02.2-1.4-2.1-1.7
Bone: tissue strength1.01.11.5-1.11.1-1.11.1-1.11.20.9-0.1
Total heroin consumption0.10.10.2-0.30.3-0.30.3-0.30.1-0.4-0.4
Bone: trabecular number0.10.10.30.1-0.10.1-0.10.6-0.6-0.40.5
Bone: trabecular spacing0.40.51.3-0.50.5-0.50.5-0.61.10.6-1.0
Bone: trabecular thickness0.40.51.2-0.60.6-0.60.6-0.60.40.71.1
Bone: trabecular tissue density2.23.34.8-1.61.6-1.61.6-2.21.92.11.5
Water consumed over 24 hours0.91.24.70.8-0.80.8-0.80.9-0.7-1.1-2.2
Number of responses in last shaping day0.70.71.41.2-1.21.2-1.2-0.1-0.70.2-0.1