Hub : Genes

Rhobtb2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Rhobtb2 0.18 0.17 8.5e-06 0.07 0.08 0.08 0.08 2.1e-04 4.1e-05 3.4e-05 3.8e-05
2 IL gene expression Rhobtb2 0.24 0.2 5.6e-04 0.1 0.1 0.06 0.1 1.8e-03 2.6e-03 1.5e-02 2.6e-03
3 Adipose gene expression Rhobtb2 0.41 0.24 0.0e+00 0.34 0.34 0.34 0.34 2.6e-38 3.2e-38 2.0e-38 6.0e-39
4 Brain gene expression Rhobtb2 0.34 0.23 0.0e+00 0.27 0.3 0.29 0.29 5.0e-25 2.9e-28 4.5e-27 6.6e-27
5 Liver gene expression Rhobtb2 0.05 0.04 4.1e-05 0.04 0.04 0.04 0.04 8.6e-05 3.5e-05 7.0e-05 7.1e-05
6 pVTA gene expression Rhobtb2 0.11 0.1 7.2e-07 0.08 0.08 0.08 0.08 1.1e-06 5.5e-07 7.6e-07 1.1e-06
7 IC gene expression Rhobtb2 0.52 0.25 0.0e+00 0.39 0.4 0.4 0.4 1.5e-17 3.3e-18 4.7e-18 5.2e-18
8 NAcc gene expression Rhobtb2 0.13 0.13 2.5e-14 0.09 0.09 0.09 0.09 3.9e-13 1.7e-13 5.9e-13 3.3e-13
9 NAcc isoform ratio NM_001013133.1 0.02 0.02 9.1e-03 0.01 0.01 0.01 0.01 4.1e-03 4.6e-03 4.4e-03 5.7e-03
10 PL gene expression Rhobtb2 0.36 0.37 0.0e+00 0.22 0.21 0.22 0.21 2.8e-23 2.8e-22 3.0e-23 3.1e-22

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density1.22.23.31.81.5-1.5-1.5-1.5-1.5-1.5-1.41.41.4
Area under the delay curve0.10.10.2-0.4-0.30.30.30.30.30.30.3-0.3-0.3
BMI with tail0.41.51.9-1.1-1.41.41.21.21.21.21.2-1.2-1.2
BMI without tail0.00.00.1-0.3-0.20.2-0.0-0.0-0.0-0.0-0.00.10.1
Body weight0.62.83.2-1.4-1.81.81.71.71.71.71.7-1.8-1.8
Weight adjusted by age0.72.22.4-1.1-1.51.51.51.51.51.51.5-1.5-1.5
Bone surface0.61.11.71.31.1-1.1-1.0-1.0-1.0-1.0-1.01.01.0
Bone volume0.61.31.71.31.1-1.1-1.1-1.1-1.1-1.1-1.11.11.1
Breakpoint value in progressive ratio session0.10.20.9-0.9-0.40.40.30.30.30.30.3-0.3-0.3
Number of licking bursts0.00.00.2-0.4-0.20.20.00.00.00.00.00.00.0
Context. condit. distance diff. score0.81.01.10.90.9-0.9-1.0-1.0-1.0-1.0-1.01.11.1
Locomotion velocity, session 10.20.20.7-0.8-0.30.30.50.50.50.50.5-0.4-0.4
Locomotion distance, session 10.00.00.2-0.50.0-0.0-0.1-0.1-0.1-0.1-0.10.20.2
Locomotion velocity, session 20.00.00.20.10.4-0.4-0.2-0.2-0.2-0.2-0.20.20.2
Locomotion distance, session 20.00.00.0-0.00.2-0.2-0.1-0.1-0.1-0.1-0.10.10.1
Locomotion velocity, session 30.60.71.5-1.2-0.80.80.80.80.80.80.8-0.7-0.7
Locomotion distance, session 30.00.00.0-0.00.1-0.1-0.2-0.2-0.2-0.2-0.20.20.2
Stereotopy head waving bouts, day 30.80.91.7-1.3-0.90.90.90.90.90.90.9-0.9-0.9
Stereotopy head waving duration, day 32.53.03.6-1.9-1.71.71.71.71.71.71.7-1.7-1.7
Locomotion velocity, session 73.94.34.52.11.9-1.9-2.1-2.1-2.1-2.1-2.12.12.1
Locomotion distance, session 73.14.04.62.21.9-1.9-2.0-2.0-2.0-2.0-2.02.02.0
Stereotopy head waving bouts, day 71.41.61.9-0.8-1.21.21.31.31.31.31.3-1.4-1.4
Stereotopy head waving duration, day 71.92.42.6-1.1-1.61.61.61.61.61.61.6-1.6-1.6
Locomotion velocity, session 80.00.00.0-0.10.2-0.2-0.0-0.0-0.0-0.0-0.00.00.0
Locomotion distance, session 80.60.80.90.70.9-0.9-0.9-0.9-0.9-0.9-0.91.01.0
Degree of sensitization distance4.34.65.92.42.1-2.1-2.1-2.1-2.1-2.1-2.12.12.1
Degree of sensitization stereotypy0.91.01.3-0.5-1.01.01.11.11.11.11.1-1.1-1.1
Conditioned locomotion0.00.00.10.30.2-0.2-0.2-0.2-0.2-0.2-0.20.20.2
Cocaine response after cond. corrected0.20.30.4-0.4-0.60.60.60.60.60.60.6-0.5-0.5
Cocaine response after cond. not corrected0.10.20.2-0.3-0.50.50.40.40.40.40.4-0.4-0.4
Cocaine response before conditioning0.20.20.40.30.6-0.6-0.4-0.4-0.4-0.4-0.40.40.4
Saline control response0.10.20.40.60.4-0.4-0.4-0.4-0.4-0.4-0.40.40.4
Bone: connectivity density2.54.05.22.31.9-1.9-2.0-2.0-2.0-2.0-2.01.91.9
Bone: cortical apparent density0.00.10.10.20.1-0.1-0.3-0.3-0.3-0.3-0.30.30.3
Bone: cortical area0.00.00.00.20.0-0.0-0.0-0.0-0.0-0.0-0.0-0.0-0.0
Bone: cortical porosity1.11.21.3-1.0-1.01.01.11.11.11.11.1-1.1-1.1
Bone: cortical porosity0.60.70.7-0.8-0.70.70.90.90.90.90.9-0.9-0.9
Bone: cortical thickness0.00.00.00.10.1-0.1-0.0-0.0-0.0-0.0-0.00.00.0
Bone: cortical thickness0.00.00.00.00.1-0.1-0.0-0.0-0.0-0.0-0.00.00.0
Bone: cortical tissue density0.10.10.10.20.2-0.2-0.3-0.3-0.3-0.3-0.30.30.3
Condit. Reinf. active minus inactive responses0.60.70.9-1.0-0.90.90.80.80.80.80.8-0.7-0.7
Condit. Reinf. active-inactive response ratio2.52.73.2-1.7-1.81.81.61.61.61.61.6-1.5-1.5
Condit. Reinf. active responses0.00.00.1-0.3-0.10.10.10.10.10.10.1-0.0-0.0
Condit. Reinf. inactive responses2.43.13.61.51.9-1.9-1.8-1.7-1.7-1.7-1.71.71.7
Incentive salience index mean0.91.11.5-1.2-1.21.21.01.01.01.01.0-0.9-0.9
Condit. Reinf. lever presses0.30.50.7-0.9-0.80.80.70.70.70.70.7-0.6-0.6
Condit. Reinf. active minus inactive responses0.30.50.50.70.7-0.7-0.7-0.7-0.7-0.7-0.70.70.7
Condit. Reinf. active-inactive response ratio0.00.10.1-0.3-0.30.30.30.30.30.30.3-0.2-0.2
Condit. Reinf. active responses0.91.31.61.21.3-1.3-1.1-1.1-1.1-1.1-1.11.11.1
Condit. Reinf. inactive responses1.82.73.01.71.7-1.7-1.6-1.6-1.6-1.6-1.61.61.6
Condit. Reinf. lever presses0.10.20.20.20.4-0.4-0.4-0.4-0.4-0.4-0.40.40.4
Condit. Reinf. lever reinforcers received0.71.01.21.01.1-1.1-1.0-1.0-1.0-1.0-1.01.01.0
Conditioned reinforcement - actives0.41.71.81.31.3-1.3-1.3-1.3-1.3-1.3-1.31.31.3
Conditioned reinforcement - inactives1.74.65.52.32.1-2.1-2.1-2.1-2.1-2.1-2.12.12.1
Conditioned locomotion0.10.20.30.50.5-0.5-0.4-0.4-0.4-0.4-0.40.40.4
Patch foraging indifference point 0 sec1.23.55.82.41.9-1.9-1.8-1.8-1.8-1.8-1.81.71.7
Patch foraging indifference point AUC0.20.52.0-1.4-0.80.80.60.60.60.60.5-0.5-0.5
Delay disc. indifference point, 0s delay0.30.30.50.30.5-0.5-0.6-0.6-0.6-0.6-0.60.70.7
Delay disc. indifference point, 16s delay0.20.20.40.60.4-0.4-0.5-0.5-0.5-0.5-0.50.40.4
Delay disc. indifference point, 2s delay1.51.71.9-1.4-1.31.31.31.31.31.31.3-1.3-1.3
Delay disc. indifference point, 24s delay0.10.20.3-0.3-0.50.50.40.40.40.40.4-0.5-0.5
Delay disc. indifference point, 4s delay1.81.92.3-1.5-1.41.41.41.41.41.41.4-1.3-1.3
Delay disc. indifference point, 8s delay0.00.00.00.00.1-0.1-0.2-0.2-0.2-0.2-0.20.20.2
Indifference point function ln k0.00.00.40.60.1-0.1-0.1-0.1-0.1-0.1-0.10.00.0
Indifference point function log k0.00.00.40.60.1-0.1-0.1-0.1-0.1-0.1-0.10.00.0
Patch foraging total patch changes 0 sec0.92.54.52.11.6-1.6-1.5-1.5-1.5-1.5-1.51.41.4
Patch foraging total patch changes 12 sec0.60.80.90.50.9-0.9-0.9-0.9-0.9-0.9-0.90.90.9
Patch foraging total patch changes 18 sec0.81.92.10.81.4-1.4-1.4-1.4-1.4-1.4-1.41.41.4
Patch foraging total patch changes 24 sec0.00.00.1-0.3-0.30.30.00.00.00.00.0-0.0-0.0
Patch foraging total patch changes 6 sec0.20.30.30.40.5-0.5-0.6-0.6-0.6-0.6-0.60.60.6
Patch foraging time to switch 0 sec0.31.01.11.00.9-0.9-1.0-1.0-1.0-1.0-1.01.01.0
Patch foraging water rate 0 sec0.10.50.6-0.3-0.70.70.70.70.70.70.7-0.8-0.8
Patch foraging water rate 12 sec0.21.01.0-0.9-1.01.01.01.01.01.01.0-1.0-1.0
Patch foraging water rate 18 sec1.73.74.3-1.6-1.71.72.02.02.02.02.0-2.1-2.1
Patch foraging water rate 24 sec0.10.20.20.2-0.30.30.40.40.40.40.4-0.5-0.5
Patch foraging water rate 6 sec2.02.93.1-1.8-1.71.71.71.71.71.71.7-1.7-1.7
Seeking ratio, delayed vs. immediate footshock1.11.64.42.11.2-1.2-1.1-1.1-1.1-1.1-1.11.01.0
Distance traveled before self-admin0.40.91.0-0.5-0.90.91.01.01.01.01.0-1.0-1.0
Distance traveled after self-admin1.72.93.2-1.5-1.51.51.81.81.81.81.8-1.8-1.8
Extensor digitorum longus weight13.152.355.1-7.4-7.47.47.27.27.27.27.2-7.1-7.1
Bone: elastic displacement0.40.40.50.50.7-0.7-0.7-0.7-0.7-0.7-0.70.70.7
Bone: elastic work0.20.20.30.50.5-0.5-0.5-0.5-0.5-0.5-0.50.50.5
Bone: endosteal estimation0.00.10.1-0.1-0.30.30.30.30.30.30.3-0.4-0.4
Bone: endosteal perimeter0.00.10.1-0.0-0.20.20.20.20.20.20.2-0.3-0.3
Epididymis fat weight0.52.52.71.71.6-1.6-1.6-1.6-1.6-1.6-1.61.61.6
Delta time in closed arm before/after self-admin4.44.16.12.52.0-2.0-1.9-1.9-1.9-2.0-2.02.02.0
Delta time in open arm before/after self-admin0.20.21.4-1.2-0.10.10.20.20.20.20.3-0.3-0.3
Diff in mean of infusions in LGA sessions0.91.63.6-1.9-1.51.51.11.11.11.11.1-1.1-1.1
Delay discount exponential model param0.40.50.70.90.7-0.7-0.7-0.7-0.7-0.7-0.70.60.6
Extinction: sum of active levers before priming1.42.12.41.11.4-1.4-1.5-1.5-1.5-1.5-1.51.51.5
Active lever presses in extinction session 60.40.40.70.30.4-0.4-0.7-0.7-0.7-0.7-0.70.80.8
Bone: final force0.10.20.3-0.3-0.60.60.40.40.40.40.4-0.4-0.4
Bone: final moment0.10.10.2-0.2-0.50.50.30.30.30.30.3-0.4-0.4
Food consumed during 24 hour testing period0.20.30.30.40.6-0.6-0.6-0.6-0.6-0.6-0.60.60.6
Glucose0.00.00.1-0.1-0.20.20.00.00.00.00.00.00.0
Heart weight0.40.71.61.30.7-0.7-0.8-0.8-0.8-0.8-0.80.80.8
Delay discount hyperbolic model param0.50.60.90.90.8-0.8-0.7-0.7-0.7-0.7-0.70.70.7
Intermittent access intake day 1-15 change0.73.64.12.02.0-2.0-1.9-1.9-1.9-1.9-1.91.91.9
Intermittent access intake escalation0.73.84.32.02.1-2.1-1.9-1.9-1.9-1.9-1.91.91.9
Intermittent access intake escalation 21.01.72.11.31.5-1.5-1.3-1.3-1.3-1.3-1.31.31.3
Intermitt. access day 1 inactive lever presses0.00.00.10.20.1-0.1-0.1-0.1-0.1-0.1-0.10.10.1
Intermitt. access day 15 inactive lever presses0.00.00.20.40.0-0.0-0.2-0.2-0.2-0.2-0.20.20.2
Intermitt. access escalation Index0.00.10.2-0.4-0.40.40.20.20.20.20.2-0.2-0.2
Intermittent access day 1 total infusions0.00.00.00.0-0.10.10.00.00.00.00.0-0.0-0.0
Intermittent access day 15 total infusions1.02.63.01.71.6-1.6-1.6-1.6-1.6-1.6-1.61.61.6
Intermittent access terminal intake (last 3 days)0.81.41.71.31.3-1.3-1.2-1.2-1.2-1.2-1.21.21.2
Intermittent access total infusions1.21.41.61.31.2-1.2-1.2-1.2-1.2-1.2-1.21.21.2
Intermittent access day 1 locomotion0.00.00.00.10.1-0.1-0.1-0.1-0.1-0.1-0.10.10.1
Intermittent access day 15 total locomotion0.10.40.60.70.8-0.8-0.6-0.6-0.6-0.6-0.60.60.6
Intermittent access total locomotion0.10.10.20.40.4-0.4-0.3-0.3-0.3-0.3-0.30.30.3
Intermittent access standard deviation0.10.30.50.60.7-0.7-0.5-0.5-0.5-0.5-0.50.50.5
Left kidney weight0.00.10.2-0.1-0.30.30.40.40.40.40.4-0.5-0.5
Right kidney weight0.00.10.1-0.0-0.20.20.20.20.20.20.2-0.3-0.3
Cocaine induced anxiety0.00.00.0-0.2-0.20.20.10.10.10.10.1-0.0-0.0
Post-drug Anxiety0.80.91.00.70.9-0.9-1.0-1.0-1.0-1.0-1.01.01.0
Baseline Anxiety0.30.50.50.50.7-0.7-0.7-0.7-0.7-0.7-0.70.70.7
Tail length0.41.92.01.31.4-1.4-1.4-1.4-1.4-1.4-1.41.41.4
Length with tail0.00.20.20.0-0.40.40.40.40.40.40.4-0.5-0.5
Length without tail1.37.17.6-2.2-2.72.72.72.72.72.72.7-2.7-2.7
Times rat made contact with spout0.50.50.60.40.8-0.8-0.8-0.8-0.8-0.8-0.80.80.8
Lifetime Intake0.70.81.01.00.9-0.9-0.9-0.9-0.9-0.9-0.90.90.9
Liver weight, left1.83.14.3-2.1-1.71.71.71.71.71.71.7-1.7-1.7
Liver weight, right0.40.80.9-0.8-0.70.70.90.90.90.90.9-0.9-0.9
Locomotor activity1.42.32.6-1.0-1.31.31.61.61.61.61.6-1.6-1.6
Locomotor testing distance0.00.10.30.50.4-0.4-0.2-0.2-0.2-0.2-0.20.20.2
Locomotor testing rearing0.10.30.50.70.7-0.7-0.5-0.5-0.5-0.5-0.50.50.5
Locomotion in novel chamber0.50.71.31.10.8-0.8-0.8-0.8-0.8-0.8-0.80.80.8
Locomotion in novel chamber post-restriction0.31.01.2-0.3-0.90.91.01.01.01.01.0-1.1-1.1
Fecal boli incidents, locomotor time 10.61.62.9-1.7-1.21.21.21.21.21.21.2-1.2-1.2
Change in fecal boli incidents, locomotor task0.20.30.4-0.2-0.60.60.50.50.50.50.5-0.5-0.5
Time >=10cm from walls, locomotor time 10.70.91.10.60.8-0.8-1.0-1.0-1.0-1.0-1.01.01.0
Bouts of movement, locomotor time 14.55.810.4-3.2-2.42.42.32.32.32.32.3-2.1-2.1
Total resting periods, locomotor time 14.95.610.0-3.2-2.42.42.32.32.32.32.3-2.1-2.1
Rest time, locomotor task time 11.62.53.9-2.0-1.71.71.51.51.51.51.5-1.4-1.4
Distance moved, locomotor task time 11.23.55.02.22.0-2.0-1.8-1.8-1.8-1.8-1.81.71.7
Vertical activity count, locomotor time 10.21.32.61.61.2-1.2-1.1-1.1-1.1-1.1-1.11.01.0
Time >=10cm from walls, locomotor time 20.20.40.5-0.6-0.70.70.70.70.70.70.7-0.6-0.6
Bouts of movement, locomotor time 21.65.37.5-2.7-2.22.22.32.32.32.32.3-2.2-2.2
Total resting periods, locomotor time 21.45.66.8-2.6-2.32.32.42.42.42.42.4-2.3-2.3
Rest time, locomotor task time 20.61.11.3-0.9-1.21.21.01.01.01.01.0-1.0-1.0
Distance moved, locomotor task time 22.83.74.72.22.0-2.0-1.9-1.9-1.9-1.9-1.91.81.8
Vertical activity count, locomotor time 20.20.50.60.70.7-0.7-0.7-0.7-0.7-0.7-0.70.70.7
Light reinforcement 11.25.57.92.82.4-2.4-2.3-2.3-2.3-2.3-2.32.22.2
Light reinforcement 20.51.11.31.10.9-0.9-1.1-1.1-1.1-1.1-1.11.11.1
Bone: marrow area0.00.00.10.0-0.20.20.20.20.20.20.2-0.2-0.2
Bone: maximum diameter0.30.60.7-0.7-0.70.70.80.80.80.80.8-0.8-0.8
Bone: maximum force0.20.50.5-0.6-0.70.70.70.70.70.70.7-0.7-0.7
Bone: maximum moment0.20.30.3-0.5-0.50.50.60.60.60.50.6-0.6-0.6
Mean time between licks in bursts0.42.42.71.41.4-1.4-1.6-1.6-1.6-1.6-1.61.61.6
Mean num. licks in bursts0.20.40.70.80.8-0.8-0.6-0.6-0.6-0.6-0.60.60.6
Cd content in liver1.31.42.2-1.5-1.21.21.11.11.11.11.1-1.1-1.1
Co content in liver5.26.17.4-2.7-2.62.62.42.42.42.42.4-2.4-2.4
Cu content in liver0.50.61.1-1.0-0.90.90.70.70.70.70.7-0.6-0.6
Fe content in liver1.72.12.51.61.5-1.5-1.4-1.4-1.4-1.4-1.41.41.4
K content in liver1.11.11.21.01.0-1.0-1.1-1.1-1.1-1.1-1.11.11.1
Mg content in liver2.52.72.81.61.6-1.6-1.7-1.7-1.7-1.7-1.71.71.7
Mn content in liver2.62.93.21.61.8-1.8-1.7-1.7-1.7-1.7-1.71.71.7
Na content in liver0.91.11.5-1.2-1.01.01.01.01.01.01.0-1.0-1.0
Rb content in liver0.00.00.20.40.2-0.2-0.2-0.2-0.2-0.2-0.20.20.2
Se content in liver1.01.21.31.11.1-1.1-1.1-1.1-1.1-1.1-1.11.11.1
Sr content in liver0.00.00.0-0.20.1-0.1-0.1-0.1-0.1-0.1-0.10.20.2
Zn content in liver0.10.10.20.10.2-0.2-0.4-0.4-0.4-0.4-0.40.40.4
Bone: minimum diameter0.10.20.3-0.2-0.50.50.50.50.50.50.5-0.5-0.5
Time in familiar zone, hab. session 10.00.00.00.1-0.10.10.20.20.20.20.2-0.2-0.2
Time in novel zone, hab. session 11.11.31.8-1.3-1.21.21.11.11.11.11.1-1.1-1.1
Total zone transitions, hab. session 10.30.41.2-1.1-0.60.60.50.50.50.50.5-0.5-0.5
Total locomotion distance, hab. session 10.00.00.2-0.50.1-0.1-0.0-0.0-0.0-0.0-0.00.10.1
Locomotion velocity, hab. session 10.10.10.1-0.20.3-0.3-0.3-0.3-0.3-0.3-0.30.40.4
Time in familiar zone, hab. session 21.92.12.2-1.5-1.41.41.51.51.51.51.5-1.5-1.5
Time in novel zone, hab. session 20.70.80.80.80.9-0.9-0.9-0.9-0.9-0.9-0.90.90.9
Total zone transitions, hab. session 21.41.92.2-1.5-1.41.41.31.31.31.31.3-1.3-1.3
Total locomotion distance, hab. session 20.30.40.7-0.8-0.60.60.60.60.60.60.5-0.5-0.5
Locomotion velocity, hab. session 20.60.81.3-1.1-0.90.90.90.90.90.90.9-0.8-0.8
Novel to familiar place preference ratio1.31.61.81.31.2-1.2-1.3-1.3-1.3-1.3-1.31.31.3
Novelty place preference1.01.31.41.21.1-1.1-1.1-1.1-1.2-1.2-1.11.11.1
Time in novel zone, NPP test0.60.70.80.90.8-0.8-0.8-0.8-0.8-0.8-0.80.80.8
Total zone transitions, NPP test0.10.20.2-0.00.4-0.4-0.4-0.4-0.4-0.4-0.50.50.5
Total locomotion distance, NPP test2.53.53.91.52.0-2.0-1.9-1.9-1.9-1.9-1.91.91.9
Locomotion velocity, NPP test2.43.43.81.51.9-1.9-1.9-1.9-1.9-1.9-1.91.91.9
Intraocular pressure0.40.70.70.80.8-0.8-0.8-0.8-0.8-0.8-0.80.80.8
Delta distance traveled before/after self-admin3.03.35.2-2.3-1.71.71.81.81.81.81.8-1.8-1.8
Delta ambulatory time before/after self-admin1.93.33.9-2.0-1.71.71.81.81.81.81.8-1.8-1.8
Parametrial fat weight2.14.96.92.62.3-2.3-2.1-2.1-2.1-2.1-2.12.02.0
Pavlov. Cond. lever latency0.00.00.00.1-0.00.0-0.0-0.0-0.0-0.0-0.00.00.0
Pavlov. Cond. magazine entry latency0.00.00.0-0.20.1-0.1-0.2-0.2-0.2-0.2-0.20.20.2
Pavlov. Cond. change in total contacts1.21.32.0-1.4-1.11.11.11.11.11.11.1-1.1-1.1
Pavlov. Cond. index score0.10.10.3-0.5-0.30.30.30.30.30.30.3-0.3-0.3
Pavlov. Cond. latency score0.00.00.2-0.4-0.10.10.20.20.20.20.2-0.2-0.2
Pavlov. Cond. lever contacts0.00.00.0-0.10.0-0.0-0.1-0.1-0.1-0.1-0.10.10.1
Pavlov. Cond. magazine entry number0.40.50.80.90.7-0.7-0.7-0.7-0.7-0.7-0.70.70.7
Pavlov. Cond. intertrial magazine entries0.10.10.20.40.4-0.4-0.4-0.4-0.4-0.4-0.40.40.4
Pavlov. Cond. lever-magazine prob. diff.0.20.30.5-0.7-0.50.50.50.50.50.50.5-0.5-0.5
Pavlov. Cond. response bias0.20.20.3-0.5-0.40.40.40.40.40.40.4-0.4-0.4
Pavlov. Cond. lever latency0.40.61.11.00.7-0.7-0.7-0.7-0.7-0.7-0.70.70.7
Pavlov. Cond. magazine entry latency0.00.10.10.10.0-0.0-0.3-0.3-0.3-0.3-0.30.30.3
Pavlov. Cond. change in total contacts0.82.02.9-1.7-1.41.41.41.41.41.41.4-1.4-1.4
Pavlov. Cond. index score0.40.61.2-1.1-0.90.90.70.70.70.70.7-0.7-0.7
Pavlov. Cond. latency score0.30.40.8-0.9-0.80.80.60.60.60.60.6-0.6-0.6
Pavlov. Cond. lever contacts0.20.30.8-0.9-0.50.50.50.50.50.50.5-0.5-0.5
Pavlov. Cond. magazine entry number0.00.00.00.10.1-0.10.20.20.20.20.2-0.2-0.2
Pavlov. Cond. intertrial magazine entries3.67.98.22.92.8-2.8-2.8-2.8-2.8-2.8-2.82.82.8
Pavlov. Cond. lever-magazine prob. diff.0.50.81.5-1.2-1.01.00.80.80.80.80.8-0.8-0.8
Pavlov. Cond. response bias0.30.40.9-0.9-0.70.70.50.50.50.50.5-0.5-0.5
Time in closed arm before self-admin1.22.02.8-1.7-1.31.31.41.41.41.41.4-1.5-1.5
Time in closed arm after self-admin0.00.00.00.2-0.10.10.20.20.20.20.2-0.2-0.2
Time in open arm before self-admin0.00.00.20.4-0.20.20.00.00.00.00.00.10.1
Time in open arm after self-admin0.10.10.3-0.60.2-0.2-0.2-0.2-0.2-0.2-0.20.20.2
Bone: periosteal estimation0.00.10.10.0-0.30.30.30.30.30.30.3-0.3-0.3
Bone: periosteal perimeter0.00.00.00.1-0.10.10.20.20.20.20.2-0.2-0.2
Bone: post-yield work0.10.20.30.60.5-0.5-0.4-0.4-0.4-0.4-0.40.40.4
Progressive ratio test 1 active lever presses0.10.10.2-0.3-0.40.40.30.30.30.30.3-0.3-0.3
Progressive ratio test 1 breakpoint0.10.20.3-0.4-0.50.50.40.40.40.40.4-0.4-0.4
Progressive ratio test 1 inactive lever presses0.41.11.41.20.9-0.9-1.1-1.1-1.1-1.1-1.11.11.1
Progressive ratio test 2 active lever presses0.00.00.10.30.2-0.2-0.2-0.2-0.2-0.2-0.20.20.2
Progressive ratio test 2 breakpoint0.00.00.10.20.1-0.1-0.1-0.1-0.1-0.1-0.10.10.1
Progressive ratio test 2 inactive lever presses0.10.40.70.90.5-0.5-0.6-0.6-0.6-0.6-0.60.60.6
Incentive Sensitization - Responses0.10.30.50.70.6-0.6-0.6-0.6-0.6-0.6-0.60.60.6
Incentive Sensitization - Breakpoint0.20.50.60.80.7-0.7-0.7-0.7-0.7-0.7-0.70.70.7
Sum of active levers in priming session hrs 5-60.10.10.10.20.2-0.2-0.3-0.3-0.3-0.3-0.30.30.3
Progressive ratio0.00.00.0-0.0-0.10.10.10.10.10.10.1-0.1-0.1
Food seeking constrained by brief footshock2.12.62.7-1.5-1.61.61.61.61.61.61.6-1.6-1.6
Seeking ratio, punishment vs. effort0.51.01.1-1.0-1.01.01.01.01.01.01.0-1.0-1.0
Retroperitoneal fat weight0.10.61.31.10.9-0.9-0.7-0.7-0.7-0.7-0.70.60.6
Reaction time number correct0.31.01.5-1.2-0.90.91.01.01.01.01.0-1.0-1.0
Reaction time mean minus median0.00.20.4-0.6-0.50.50.40.40.40.40.4-0.4-0.4
Reaction time mean minus median AUC0.00.10.4-0.6-0.40.40.30.30.30.30.3-0.3-0.3
Reaction time num false alarms0.10.10.20.10.0-0.00.30.30.30.30.4-0.4-0.4
Reaction time num false alarms AUC0.00.10.10.30.0-0.00.20.20.30.30.3-0.4-0.4
Reaction time trials correct on left0.31.01.5-1.2-0.90.91.01.01.01.01.0-1.0-1.0
Reaction time trials on left0.20.71.2-1.1-0.80.80.90.90.90.90.9-0.8-0.8
Reaction time mean0.20.41.1-1.1-0.70.70.50.50.50.50.5-0.4-0.4
Reaction time mean AUC0.20.61.5-1.2-0.80.80.70.70.70.70.7-0.6-0.6
Median of all reaction times0.20.31.1-1.0-0.60.60.40.40.40.40.4-0.4-0.4
Reaction time omissions1.52.52.91.71.4-1.4-1.6-1.6-1.6-1.6-1.61.61.6
Reaction time false alarm rate0.10.20.80.90.5-0.5-0.3-0.3-0.3-0.3-0.30.20.2
Reaction time premature initiation rate1.72.63.0-1.2-1.71.71.61.61.61.61.6-1.6-1.6
Reaction time premature initiations1.23.73.9-1.7-2.02.02.02.02.02.02.0-2.0-2.0
Std. dev. reaction times0.10.20.6-0.8-0.60.60.40.40.40.40.4-0.4-0.4
Reaction time trials completed0.20.71.2-1.1-0.80.80.90.90.90.90.9-0.8-0.8
Reaction time trials AUC0.20.71.2-1.1-0.70.70.80.80.80.80.8-0.8-0.8
Run reversals in cocaine runway, females2.73.03.11.51.8-1.8-1.8-1.8-1.8-1.8-1.81.71.7
Run reversals in cocaine runway, males1.82.02.1-1.5-1.41.41.41.41.41.41.4-1.4-1.4
Latency to leave start box in cocaine runway0.30.40.6-0.3-0.60.60.70.70.70.70.7-0.8-0.8
Latency to leave start box in cocaine runway, F1.11.41.7-0.9-1.21.21.21.21.21.21.2-1.3-1.3
Latency to leave start box in cocaine runway, M0.10.10.10.30.3-0.3-0.3-0.3-0.3-0.3-0.30.30.3
Std. dev. time between licks in bursts0.91.61.81.41.1-1.1-1.3-1.3-1.3-1.3-1.31.31.3
Total sessions with >9 infusions0.10.10.1-0.1-0.40.40.20.20.20.20.2-0.2-0.2
Short access day 1 total inactive lever presses0.10.20.40.60.3-0.3-0.4-0.4-0.4-0.4-0.40.40.4
Short access day 10 total inactive lever presses0.00.30.50.70.5-0.5-0.5-0.5-0.5-0.5-0.50.50.5
Short access day 1 total infusions0.00.10.10.1-0.30.30.30.30.30.30.3-0.3-0.3
Short access day 10 total infusions0.20.40.5-0.4-0.70.70.60.60.60.60.6-0.6-0.6
Short access total infusions0.00.10.10.1-0.30.30.20.20.20.20.2-0.2-0.2
Short access day 1 locomotion0.61.01.1-0.8-1.01.01.01.01.01.01.0-1.0-1.0
Short access day 10 total locomotion0.00.00.00.20.0-0.0-0.1-0.1-0.1-0.1-0.10.10.1
Short access total locomotion0.10.10.2-0.2-0.40.40.40.40.40.40.4-0.4-0.4
One hour access (0.3 mA shock)0.70.81.00.81.0-1.0-0.9-0.9-0.9-0.9-0.90.90.9
Compulsive drug intake0.60.81.30.81.1-1.1-0.9-0.9-0.9-0.9-0.90.90.9
One hour access (shock baseline)0.00.00.00.0-0.10.10.00.00.00.00.0-0.0-0.0
Social response proportion0.10.10.1-0.1-0.10.10.40.40.40.40.4-0.4-0.4
Social responses1.21.62.21.21.5-1.5-1.2-1.2-1.2-1.2-1.21.21.2
Social time0.50.82.41.51.1-1.1-0.7-0.7-0.7-0.7-0.70.60.6
Soleus weight1.23.63.8-1.8-1.91.91.91.91.91.91.9-1.9-1.9
Bone: stiffness0.61.11.2-0.9-1.11.11.11.11.11.11.1-1.1-1.1
Tibialis anterior weight8.428.933.0-5.7-5.45.45.35.35.35.35.3-5.3-5.3
Time to tail flick, vehicle, before self-admin0.81.01.00.91.0-1.0-1.0-1.0-1.0-1.0-1.01.01.0
Time to tail flick, vehicle, after self-admin1.02.02.4-1.4-1.51.51.41.41.41.41.4-1.4-1.4
Time to tail flick, test, before self-admin2.42.83.11.41.6-1.6-1.7-1.7-1.7-1.7-1.71.81.8
Time to tail flick, test, after self-admin2.72.94.82.21.9-1.9-1.6-1.6-1.6-1.6-1.61.61.6
Delta time to tail flick, vehicle, before/after SA0.30.30.3-0.4-0.60.60.50.50.50.50.5-0.5-0.5
Delta time to tail flick, test, before/after SA0.10.10.40.60.5-0.5-0.1-0.1-0.1-0.1-0.10.10.1
Tibia length1.23.44.02.01.7-1.7-1.8-1.8-1.8-1.8-1.81.81.8
Ambulatory time before self-admin0.10.30.4-0.5-0.60.60.60.60.60.60.6-0.6-0.6
Ambulatory time after self-admin3.75.96.2-2.4-2.32.32.52.52.52.52.5-2.5-2.5
Bone: tissue strength0.10.10.20.50.2-0.2-0.2-0.2-0.2-0.2-0.20.20.2
Total heroin consumption0.70.81.5-1.2-1.01.00.80.80.80.80.8-0.8-0.8
Bone: trabecular number2.03.85.12.31.9-1.9-1.9-1.9-1.9-1.9-1.91.91.9
Bone: trabecular spacing2.13.13.3-1.8-1.81.81.71.71.71.71.7-1.7-1.7
Bone: trabecular thickness1.01.41.51.21.1-1.1-1.2-1.2-1.2-1.2-1.21.21.2
Bone: trabecular tissue density1.11.92.5-1.6-1.31.31.41.41.41.41.4-1.4-1.4
Water consumed over 24 hours1.01.92.8-1.7-1.41.41.31.31.31.31.3-1.3-1.3
Number of responses in last shaping day0.60.71.1-0.7-1.01.00.80.80.80.80.8-0.8-0.8