Mnt

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Mnt	0.06	0.05	2.4e-03	0.01	-0	-0	-0	5.1e-02	4.7e-01	4.3e-01	3.8e-01
2	NAcc	gene expression	Mnt	0.07	0.05	3.4e-06	0.04	0.05	0.04	0.04	1.3e-05	7.2e-07	1.6e-05	5.4e-06
3	PL	intron excision ratio	chr10_59706563_59711286	0.02	0.01	7.8e-03	0.01	0.02	0.02	0.01	8.2e-03	4.8e-03	4.8e-03	1.2e-02
4	PL	mRNA stability	Mnt	0.04	0.04	5.3e-05	0.04	0.03	0.04	0.04	9.9e-06	1.5e-04	3.4e-05	2.6e-05
5	LHb	intron excision ratio	chr10_59709191_59711286	0.68	0.18	2.8e-03	0.06	0.04	0.06	0.07	1.5e-02	3.8e-02	1.3e-02	9.1e-03
6	LHb	intron excision ratio	chr10_59706563_59711286	0.6	0.23	2.5e-03	0.07	0.03	0.05	0.08	9.7e-03	6.4e-02	2.5e-02	5.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	3.1	5.2	8.5	2.6	-2.9	-2.3	1.3	-2.1	2.1
Area under the delay curve	0.7	0.8	2.1	-0.6	1.5	0.8	-1.0	0.5	-0.5
BMI with tail	1.1	3.6	6.0	2.4	-2.0	-2.3	1.5	-1.4	1.4
BMI without tail	0.4	0.8	1.4	1.1	-0.7	-0.6	-0.1	-1.2	1.2
Body weight	1.2	5.0	9.5	2.1	-2.4	-0.6	-0.7	-3.1	3.1
Weight adjusted by age	1.6	1.8	3.4	1.9	-1.0	-1.6	0.6	-1.3	1.3
Bone surface	3.1	5.4	8.0	2.8	-2.8	-2.7	1.7	-1.8	1.8
Bone volume	3.3	5.6	8.5	2.9	-2.8	-2.7	1.8	-1.8	1.8
Breakpoint value in progressive ratio session	1.1	1.2	2.4	1.0	-0.9	-0.3	-0.6	-1.5	1.5
Number of licking bursts	0.3	0.3	0.5	-0.6	0.7	0.4	-0.2	0.7	-0.7
Context. condit. distance diff. score	1.1	1.4	2.0	1.3	-1.4	-0.8	0.3	-1.4	1.4
Locomotion velocity, session 1	2.6	2.9	5.1	1.6	-2.1	-0.5	-0.0	-2.3	2.3
Locomotion distance, session 1	0.6	0.8	1.2	0.9	-1.1	-0.8	0.9	-0.7	0.7
Locomotion velocity, session 2	0.6	0.7	1.3	0.8	-1.2	-0.5	0.6	-0.9	0.9
Locomotion distance, session 2	1.5	2.1	3.1	1.7	-1.8	-1.4	1.2	-1.3	1.3
Locomotion velocity, session 3	4.4	5.1	8.1	-2.8	2.6	2.5	-1.6	1.9	-1.8
Locomotion distance, session 3	0.1	0.1	0.3	0.1	-0.0	-0.3	0.6	0.2	-0.2
Stereotopy head waving bouts, day 3	0.3	0.3	0.9	-0.7	0.0	1.0	-0.7	-0.1	0.2
Stereotopy head waving duration, day 3	0.4	0.4	0.8	-0.8	0.4	0.5	0.1	0.9	-0.9
Locomotion velocity, session 7	1.4	1.5	3.0	1.7	-1.1	-1.6	1.0	-0.8	0.8
Locomotion distance, session 7	2.3	3.0	6.1	2.5	-1.6	-2.2	1.1	-1.3	1.3
Stereotopy head waving bouts, day 7	0.5	0.6	1.6	0.5	-1.3	-0.4	0.5	-0.8	0.8
Stereotopy head waving duration, day 7	0.8	1.0	2.3	0.8	-1.5	-0.7	0.7	-1.0	1.0
Locomotion velocity, session 8	0.4	0.5	0.8	0.6	-0.9	-0.7	0.8	-0.5	0.5
Locomotion distance, session 8	2.1	3.0	4.4	1.9	-2.1	-1.1	0.4	-2.1	2.1
Degree of sensitization distance	1.3	1.3	2.5	1.6	-1.1	-0.9	-0.1	-1.3	1.3
Degree of sensitization stereotypy	0.9	1.0	2.1	0.8	-1.5	-0.4	0.2	-1.3	1.3
Conditioned locomotion	0.9	1.0	1.9	-1.2	0.8	0.6	0.3	1.4	-1.4
Cocaine response after cond. corrected	0.1	0.2	0.3	-0.2	-0.1	0.4	-0.6	-0.4	0.4
Cocaine response after cond. not corrected	0.3	0.3	0.6	0.2	-0.5	0.2	-0.5	-0.8	0.8
Cocaine response before conditioning	1.0	1.2	1.8	1.3	-1.3	-0.9	0.5	-1.2	1.2
Saline control response	0.8	1.1	1.8	1.3	-0.9	-1.4	1.1	-0.6	0.6
Bone: connectivity density	4.8	7.5	11.6	3.1	-3.4	-2.9	1.8	-2.4	2.4
Bone: cortical apparent density	0.3	0.4	0.8	-0.3	0.5	-0.2	0.6	0.9	-0.9
Bone: cortical area	1.1	1.7	3.5	-1.1	1.9	0.7	-0.8	1.4	-1.4
Bone: cortical porosity	0.2	0.2	0.4	0.6	-0.4	-0.3	0.0	-0.6	0.6
Bone: cortical porosity	0.0	0.0	0.1	0.3	-0.0	-0.0	-0.2	-0.3	0.3
Bone: cortical thickness	4.5	7.3	11.0	-3.2	3.3	2.7	-2.3	2.3	-2.3
Bone: cortical thickness	1.3	1.5	2.5	-1.4	1.2	1.6	-1.6	0.5	-0.5
Bone: cortical tissue density	0.2	0.3	0.6	-0.2	0.4	-0.3	0.7	0.7	-0.8
Condit. Reinf. active minus inactive responses	0.2	0.3	0.7	-0.6	0.4	0.8	-0.7	0.1	-0.1
Condit. Reinf. active-inactive response ratio	2.5	2.7	5.2	-1.9	1.6	2.3	-2.2	0.5	-0.4
Condit. Reinf. active responses	0.2	0.3	0.5	0.7	-0.6	-0.6	0.5	-0.4	0.4
Condit. Reinf. inactive responses	3.8	4.5	8.5	2.5	-2.0	-2.9	2.8	-0.6	0.6
Incentive salience index mean	0.3	0.3	0.9	-0.6	0.1	0.9	-0.8	-0.2	0.2
Condit. Reinf. lever presses	0.6	0.7	1.4	0.1	-0.8	0.6	-0.8	-1.2	1.2
Condit. Reinf. active minus inactive responses	0.8	0.9	1.9	1.4	-0.8	-1.3	0.6	-0.8	0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.1	0.2	0.1	-0.5	-0.3	0.3
Condit. Reinf. active responses	1.8	2.5	5.1	2.2	-1.3	-2.2	1.5	-0.8	0.8
Condit. Reinf. inactive responses	3.5	4.3	9.0	2.5	-1.7	-3.0	2.7	-0.4	0.4
Condit. Reinf. lever presses	0.5	0.7	1.5	0.3	0.2	-0.9	1.2	0.9	-0.9
Condit. Reinf. lever reinforcers received	1.8	2.6	5.4	2.2	-1.2	-2.3	1.6	-0.7	0.7
Conditioned reinforcement - actives	2.4	2.4	4.3	1.9	-1.6	-2.1	1.6	-1.0	0.9
Conditioned reinforcement - inactives	1.2	1.3	2.4	1.6	-0.8	-1.5	1.1	-0.9	0.8
Conditioned locomotion	0.1	0.1	0.3	-0.1	0.3	-0.2	0.2	0.5	-0.5
Patch foraging indifference point 0 sec	0.1	0.2	0.3	0.4	-0.6	-0.4	0.4	-0.3	0.3
Patch foraging indifference point AUC	0.4	0.5	0.9	0.3	0.4	-0.8	1.0	0.8	-0.8
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	0.5	-0.3	-0.4	0.2	-0.4	0.4
Delay disc. indifference point, 16s delay	0.3	0.3	1.1	0.1	1.1	-0.1	-0.5	0.4	-0.4
Delay disc. indifference point, 2s delay	0.7	0.8	1.7	-0.9	1.3	0.9	-0.8	0.7	-0.7
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.2	0.6	-0.0	-0.4	-0.0	0.0
Delay disc. indifference point, 4s delay	0.4	0.4	1.2	-0.3	1.0	0.6	-1.1	-0.0	0.0
Delay disc. indifference point, 8s delay	0.4	0.4	1.1	-0.4	1.0	0.7	-0.8	0.1	-0.1
Indifference point function ln k	0.5	0.8	1.4	0.7	-1.2	-0.4	0.2	-1.1	1.1
Indifference point function log k	0.5	0.8	1.4	0.7	-1.2	-0.4	0.2	-1.1	1.1
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	0.4	-0.6	-0.5	0.6	-0.2	0.2
Patch foraging total patch changes 12 sec	0.5	0.7	1.2	-1.1	0.9	0.9	-0.6	0.6	-0.6
Patch foraging total patch changes 18 sec	0.4	0.5	0.9	-0.7	1.0	0.6	-0.7	0.6	-0.6
Patch foraging total patch changes 24 sec	0.6	0.8	1.2	-0.9	1.1	0.5	-0.3	1.1	-1.1
Patch foraging total patch changes 6 sec	0.3	0.4	0.8	-0.2	0.3	-0.4	0.7	0.9	-0.9
Patch foraging time to switch 0 sec	1.6	2.4	4.8	-1.9	1.2	2.2	-2.1	0.5	-0.5
Patch foraging water rate 0 sec	0.5	0.8	2.2	0.8	-0.6	-1.2	1.5	0.1	-0.2
Patch foraging water rate 12 sec	0.1	0.2	0.4	0.7	-0.2	-0.3	-0.0	-0.6	0.6
Patch foraging water rate 18 sec	2.8	3.7	5.6	2.4	-2.2	-2.0	1.6	-1.7	1.6
Patch foraging water rate 24 sec	0.3	0.4	1.0	0.6	-0.6	-0.7	1.0	-0.1	0.1
Patch foraging water rate 6 sec	0.1	0.2	0.3	-0.1	0.4	-0.1	0.5	0.5	-0.5
Seeking ratio, delayed vs. immediate footshock	0.8	1.0	1.8	-0.7	1.3	0.2	0.3	1.3	-1.3
Distance traveled before self-admin	1.3	1.4	2.8	-1.2	1.7	0.8	-0.5	1.3	-1.3
Distance traveled after self-admin	0.1	0.1	0.3	0.0	0.2	0.1	-0.5	-0.3	0.3
Extensor digitorum longus weight	4.5	17.6	25.5	4.9	-5.1	-4.8	4.2	-2.9	2.8
Bone: elastic displacement	0.5	0.6	1.4	-0.6	0.7	-0.0	0.4	1.2	-1.2
Bone: elastic work	4.2	5.4	8.0	-2.8	2.6	2.3	-1.7	2.2	-2.2
Bone: endosteal estimation	0.2	0.4	0.9	0.8	-0.4	-1.0	0.7	-0.1	0.1
Bone: endosteal perimeter	1.3	2.7	5.7	2.2	-1.2	-2.4	1.9	-0.6	0.5
Epididymis fat weight	3.7	8.7	12.4	3.5	-3.1	-2.3	0.6	-3.5	3.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.1	0.4	-0.2	0.5	0.3	-0.3
Delta time in open arm before/after self-admin	0.5	0.5	1.0	0.7	-1.0	-0.6	-0.2	-0.7	0.7
Diff in mean of infusions in LGA sessions	0.6	0.6	1.3	0.2	-0.5	0.4	-0.9	-1.1	1.1
Delay discount exponential model param	0.8	0.8	2.1	0.7	-1.4	-0.9	1.2	-0.4	0.3
Extinction: sum of active levers before priming	3.2	3.2	4.9	2.2	-1.8	-1.5	0.7	-2.1	2.0
Active lever presses in extinction session 6	1.5	1.5	2.1	1.4	-1.4	-1.2	0.6	-1.2	1.2
Bone: final force	0.8	1.3	3.3	-1.2	1.0	1.5	-1.8	0.2	-0.2
Bone: final moment	0.7	1.1	2.4	-1.1	0.9	1.3	-1.5	0.3	-0.3
Food consumed during 24 hour testing period	0.3	0.4	0.5	0.7	-0.7	-0.5	0.2	-0.7	0.7
Glucose	2.4	3.6	6.6	-1.9	2.6	1.2	-0.9	2.1	-2.1
Heart weight	0.3	0.4	0.9	0.6	-0.3	-0.1	-0.5	-0.9	0.9
Delay discount hyperbolic model param	0.7	0.8	2.0	0.6	-1.4	-0.9	1.0	-0.4	0.4
Intermittent access intake day 1-15 change	1.5	1.4	3.4	0.3	0.1	-1.4	1.8	1.3	-1.3
Intermittent access intake escalation	1.6	1.5	3.1	-0.2	0.8	-0.9	1.3	1.7	-1.8
Intermittent access intake escalation 2	2.4	2.4	5.4	-1.1	1.2	-0.1	1.0	2.3	-2.3
Intermitt. access day 1 inactive lever presses	1.3	1.4	4.1	-0.8	2.0	0.6	-0.6	1.2	-1.2
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.8	0.4	0.9	-0.3	0.2	-0.1	0.0
Intermitt. access escalation Index	2.2	1.9	5.1	-0.6	-0.7	1.5	-2.3	-1.2	1.3
Intermittent access day 1 total infusions	1.0	1.2	2.1	1.4	-0.9	-1.2	0.7	-1.1	1.0
Intermittent access day 15 total infusions	1.7	1.9	4.4	1.4	-0.7	-2.1	2.1	0.3	-0.4
Intermittent access terminal intake (last 3 days)	1.6	1.8	3.2	1.5	-1.4	-1.8	1.6	-0.5	0.5
Intermittent access total infusions	1.0	1.1	2.5	1.3	-0.6	-1.6	1.4	-0.2	0.2
Intermittent access day 1 locomotion	0.2	0.2	0.4	0.2	0.6	0.2	-0.6	-0.4	0.4
Intermittent access day 15 total locomotion	0.3	0.4	0.5	0.2	0.5	-0.6	0.6	0.7	-0.7
Intermittent access total locomotion	0.1	0.1	0.1	0.4	0.2	-0.4	0.2	-0.1	0.0
Intermittent access standard deviation	2.4	2.6	6.0	0.7	0.5	-1.9	2.5	1.5	-1.6
Left kidney weight	2.7	7.6	12.6	-3.0	3.0	3.4	-3.5	1.3	-1.2
Right kidney weight	2.3	6.5	12.5	-2.7	2.7	3.2	-3.5	0.9	-0.9
Cocaine induced anxiety	0.5	0.5	1.4	0.3	0.1	-0.9	1.2	0.7	-0.7
Post-drug Anxiety	0.2	0.2	0.6	0.4	-0.4	-0.5	0.8	-0.0	0.0
Baseline Anxiety	0.1	0.1	0.3	-0.1	-0.0	0.3	-0.6	-0.3	0.4
Tail length	1.8	5.5	13.0	-0.8	-0.3	2.7	-3.6	-2.4	2.5
Length with tail	1.0	3.5	6.3	-0.3	-0.8	1.9	-2.5	-2.2	2.3
Length without tail	0.8	1.7	3.1	0.9	-1.7	-0.0	-0.3	-1.8	1.8
Times rat made contact with spout	1.3	1.4	3.0	-1.3	1.2	1.6	-1.7	0.3	-0.3
Lifetime Intake	1.1	1.3	2.7	1.4	-0.6	-1.6	1.6	-0.3	0.3
Liver weight, left	1.1	1.7	5.1	-0.5	0.1	1.4	-2.3	-1.1	1.2
Liver weight, right	0.7	1.1	2.1	0.3	-0.5	0.6	-1.4	-1.4	1.5
Locomotor activity	0.2	0.2	0.6	0.8	-0.2	-0.6	-0.2	-0.4	0.4
Locomotor testing distance	0.0	0.0	0.1	0.0	-0.2	-0.2	-0.1	0.2	-0.2
Locomotor testing rearing	0.4	0.7	1.7	0.9	-0.7	-1.3	1.0	0.3	-0.3
Locomotion in novel chamber	2.4	3.0	6.1	-0.5	1.4	-0.9	1.7	2.4	-2.5
Locomotion in novel chamber post-restriction	0.2	0.2	0.7	0.2	-0.4	-0.5	0.8	0.3	-0.3
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.3	-0.2	0.4	-0.1	-0.1	0.1
Change in fecal boli incidents, locomotor task	0.4	0.4	0.7	-0.7	0.6	0.8	-0.8	0.4	-0.4
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	0.2	-0.3	-0.4	0.5	0.1	-0.1
Bouts of movement, locomotor time 1	0.2	0.2	0.3	0.4	-0.6	-0.2	0.5	-0.4	0.4
Total resting periods, locomotor time 1	0.2	0.2	0.4	0.4	-0.5	-0.3	0.6	-0.3	0.3
Rest time, locomotor task time 1	0.3	0.3	0.7	-0.0	0.0	-0.3	0.8	0.7	-0.7
Distance moved, locomotor task time 1	0.1	0.2	0.3	0.6	-0.2	-0.5	0.3	-0.3	0.3
Vertical activity count, locomotor time 1	0.6	0.6	0.9	0.9	-0.9	-0.9	0.7	-0.6	0.6
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.1	-0.5	1.1	0.5	-0.6	0.4	-0.4
Bouts of movement, locomotor time 2	0.1	0.1	0.2	-0.0	0.4	0.2	-0.5	-0.0	0.0
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.3	0.0	-0.0	-0.3	-0.3	0.3
Rest time, locomotor task time 2	0.1	0.2	0.4	0.6	-0.3	-0.6	0.5	0.1	-0.1
Distance moved, locomotor task time 2	0.2	0.2	0.7	0.1	0.1	-0.4	0.9	0.5	-0.5
Vertical activity count, locomotor time 2	0.3	0.3	0.7	-0.8	0.5	0.8	-0.3	0.4	-0.4
Light reinforcement 1	0.0	0.0	0.1	0.3	-0.3	-0.3	0.1	0.0	-0.0
Light reinforcement 2	2.2	2.9	4.2	-2.0	1.9	2.1	-1.7	1.2	-1.1
Bone: marrow area	0.2	0.3	0.8	0.8	-0.4	-0.9	0.7	-0.0	0.0
Bone: maximum diameter	0.4	0.7	1.9	0.8	0.0	-1.4	1.1	0.5	-0.6
Bone: maximum force	0.8	1.5	2.7	-1.4	1.2	1.5	-1.7	0.5	-0.4
Bone: maximum moment	0.7	1.2	1.8	-1.3	1.2	1.3	-1.3	0.6	-0.6
Mean time between licks in bursts	0.3	0.5	1.1	-0.4	-0.1	0.9	-1.0	-0.6	0.7
Mean num. licks in bursts	0.3	0.3	1.0	-0.3	0.1	0.7	-1.0	-0.5	0.5
Cd content in liver	1.2	1.3	2.1	1.5	-1.1	-1.3	1.0	-0.9	0.9
Co content in liver	0.1	0.1	0.3	0.1	0.5	-0.0	-0.3	0.1	-0.1
Cu content in liver	0.8	1.0	1.7	-1.0	1.2	1.3	-1.3	0.4	-0.4
Fe content in liver	0.4	0.5	1.2	-0.4	-0.1	0.9	-1.1	-0.7	0.7
K content in liver	1.3	1.2	3.4	-1.0	0.4	1.6	-1.8	-0.4	0.5
Mg content in liver	0.0	0.0	0.1	0.1	0.1	-0.2	0.2	0.3	-0.3
Mn content in liver	0.1	0.1	0.4	0.2	-0.7	-0.2	0.5	-0.2	0.2
Na content in liver	2.6	2.7	3.9	-2.0	1.9	1.9	-1.5	1.2	-1.2
Rb content in liver	1.7	2.1	3.9	1.8	-1.3	-2.0	1.6	-0.7	0.7
Se content in liver	1.0	1.2	1.8	-1.3	1.2	1.3	-1.0	0.8	-0.8
Sr content in liver	0.5	0.5	0.9	0.7	-1.0	-0.6	0.6	-0.7	0.7
Zn content in liver	0.5	0.5	1.0	0.9	-0.7	-1.0	0.9	-0.1	0.1
Bone: minimum diameter	0.5	1.0	1.9	-0.8	1.4	1.0	-1.4	0.5	-0.5
Time in familiar zone, hab. session 1	1.2	1.2	2.5	1.1	-0.9	-1.6	1.6	-0.0	-0.0
Time in novel zone, hab. session 1	1.1	1.1	3.1	-0.9	0.9	1.3	-1.8	0.0	-0.0
Total zone transitions, hab. session 1	2.2	3.0	5.2	2.1	-1.7	-2.3	2.1	-0.8	0.8
Total locomotion distance, hab. session 1	0.6	0.9	1.4	1.2	-1.0	-1.1	1.0	-0.6	0.6
Locomotion velocity, hab. session 1	0.6	0.9	1.5	1.1	-1.1	-1.0	1.2	-0.5	0.5
Time in familiar zone, hab. session 2	1.7	1.7	2.5	1.6	-1.5	-1.5	1.4	-0.8	0.8
Time in novel zone, hab. session 2	4.0	4.0	5.8	-2.4	2.3	2.3	-2.1	1.3	-1.2
Total zone transitions, hab. session 2	1.0	1.3	2.0	1.3	-1.4	-1.0	0.9	-1.1	1.1
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.1	-0.4	0.3	0.1	-0.3	0.3
Locomotion velocity, hab. session 2	0.0	0.1	0.1	-0.1	-0.3	0.4	0.0	-0.2	0.2
Novel to familiar place preference ratio	0.2	0.2	0.4	0.3	0.4	-0.6	0.5	0.4	-0.5
Novelty place preference	0.0	0.0	0.1	0.2	0.3	-0.3	0.1	0.1	-0.1
Time in novel zone, NPP test	0.1	0.1	0.2	0.4	-0.0	-0.5	0.2	-0.2	0.2
Total zone transitions, NPP test	1.3	1.9	3.0	1.7	-1.4	-1.7	1.6	-0.7	0.7
Total locomotion distance, NPP test	0.4	0.6	1.6	0.7	-0.5	-1.0	1.3	0.2	-0.2
Locomotion velocity, NPP test	0.4	0.6	1.7	0.3	-0.0	-0.8	1.3	0.7	-0.7
Intraocular pressure	1.4	1.9	4.6	1.4	-0.1	-2.1	2.0	0.7	-0.7
Delta distance traveled before/after self-admin	1.5	1.6	2.9	1.1	-1.5	-0.4	-0.2	-1.7	1.7
Delta ambulatory time before/after self-admin	1.0	1.1	2.1	0.8	-1.4	-0.2	-0.2	-1.4	1.4
Parametrial fat weight	5.6	10.8	18.3	2.9	-4.3	-1.3	-0.0	-4.3	4.3
Pavlov. Cond. lever latency	0.3	0.4	1.0	0.6	-0.3	-1.0	1.0	0.1	-0.2
Pavlov. Cond. magazine entry latency	0.3	0.4	0.7	-0.1	-0.5	0.6	-0.8	-0.8	0.8
Pavlov. Cond. change in total contacts	0.6	0.6	1.0	-1.0	0.8	1.0	-0.6	0.7	-0.6
Pavlov. Cond. index score	0.5	0.6	1.0	-0.3	-0.4	0.9	-1.0	-0.8	0.8
Pavlov. Cond. latency score	0.7	0.8	1.8	-0.4	-0.2	1.2	-1.3	-0.9	0.9
Pavlov. Cond. lever contacts	0.3	0.3	0.9	-0.5	0.2	0.9	-0.9	-0.3	0.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.1	0.3	-0.4	0.3	0.3	-0.3
Pavlov. Cond. intertrial magazine entries	0.9	1.0	2.7	1.0	-0.5	-1.4	1.6	0.2	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.6	-0.3	-0.4	0.8	-0.8	-0.7	0.7
Pavlov. Cond. response bias	0.2	0.2	0.3	-0.2	-0.4	0.5	-0.5	-0.5	0.5
Pavlov. Cond. lever latency	0.6	0.9	1.8	0.5	-1.4	-0.1	0.1	-1.2	1.2
Pavlov. Cond. magazine entry latency	1.0	1.2	1.9	-1.1	1.3	1.3	-1.4	0.6	-0.6
Pavlov. Cond. change in total contacts	0.5	0.7	1.4	-0.8	1.2	0.6	-0.6	0.9	-0.9
Pavlov. Cond. index score	0.9	1.2	2.5	-0.8	1.6	0.5	-0.4	1.4	-1.4
Pavlov. Cond. latency score	1.2	1.5	2.9	-1.0	1.7	0.5	-0.3	1.6	-1.6
Pavlov. Cond. lever contacts	0.5	0.6	1.3	-0.7	1.1	0.5	-0.5	0.9	-0.9
Pavlov. Cond. magazine entry number	1.1	1.3	2.1	1.2	-1.5	-1.2	1.2	-0.9	0.9
Pavlov. Cond. intertrial magazine entries	2.0	2.6	3.7	1.9	-1.9	-1.8	1.5	-1.3	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	2.2	-0.8	1.5	0.4	-0.3	1.3	-1.3
Pavlov. Cond. response bias	0.7	1.0	2.0	-0.9	1.4	0.8	-0.9	1.0	-1.0
Time in closed arm before self-admin	0.9	1.0	2.5	0.4	-1.6	0.2	-0.2	-1.3	1.3
Time in closed arm after self-admin	0.1	0.1	0.4	-0.5	0.3	0.7	-0.1	0.1	-0.0
Time in open arm before self-admin	2.5	2.7	7.5	-1.3	2.7	1.0	-0.9	1.7	-1.6
Time in open arm after self-admin	0.5	0.5	1.2	-0.2	1.1	-0.2	-0.4	0.9	-0.9
Bone: periosteal estimation	0.2	0.3	0.8	-0.3	0.9	0.0	-0.3	0.7	-0.7
Bone: periosteal perimeter	0.2	0.3	1.0	0.7	0.3	-1.0	0.6	0.3	-0.3
Bone: post-yield work	0.3	0.4	0.9	0.4	-0.5	0.1	-0.4	-1.0	1.0
Progressive ratio test 1 active lever presses	1.6	1.6	3.3	1.8	-0.6	-1.4	0.7	-1.4	1.3
Progressive ratio test 1 breakpoint	2.6	2.7	4.9	2.2	-1.0	-1.6	0.8	-1.9	1.8
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.6	0.4	0.8	-0.3	0.1	-0.0	0.0
Progressive ratio test 2 active lever presses	1.7	1.9	3.8	2.0	-0.5	-1.7	1.3	-1.1	1.1
Progressive ratio test 2 breakpoint	1.7	1.9	3.9	2.0	-0.4	-1.8	1.3	-1.1	1.0
Progressive ratio test 2 inactive lever presses	1.0	1.2	2.6	1.6	0.0	-1.6	1.2	-0.6	0.6
Incentive Sensitization - Responses	1.0	1.0	2.4	1.6	-0.1	-1.3	0.8	-0.9	0.9
Incentive Sensitization - Breakpoint	0.8	0.8	1.8	1.4	-0.0	-1.1	0.7	-0.8	0.8
Sum of active levers in priming session hrs 5-6	2.5	2.4	4.2	1.8	-1.4	-1.0	-0.3	-2.0	2.0
Progressive ratio	0.4	0.5	1.8	0.5	-0.6	-0.8	1.3	0.0	-0.0
Food seeking constrained by brief footshock	0.1	0.2	0.3	-0.5	0.4	0.5	-0.1	0.4	-0.4
Seeking ratio, punishment vs. effort	0.9	1.1	1.9	-1.1	1.0	1.4	-1.4	0.5	-0.5
Retroperitoneal fat weight	0.0	0.0	0.1	0.0	0.2	-0.2	-0.3	0.3	-0.3
Reaction time number correct	0.1	0.1	0.3	0.5	-0.3	-0.2	-0.2	-0.4	0.4
Reaction time mean minus median	0.2	0.3	0.6	-0.4	0.1	-0.1	0.7	0.8	-0.8
Reaction time mean minus median AUC	0.7	0.9	2.7	0.7	-1.0	-1.2	1.6	0.2	-0.2
Reaction time num false alarms	0.9	1.2	2.8	0.7	-0.2	-1.5	1.7	0.9	-0.9
Reaction time num false alarms AUC	0.8	1.1	2.6	0.6	-0.1	-1.4	1.6	0.8	-0.9
Reaction time trials correct on left	0.1	0.1	0.3	0.5	-0.3	-0.2	-0.2	-0.4	0.4
Reaction time trials on left	0.1	0.1	0.3	0.5	-0.3	-0.3	-0.1	-0.4	0.4
Reaction time mean	0.2	0.3	0.6	-0.8	0.4	0.5	-0.2	0.6	-0.6
Reaction time mean AUC	0.4	0.6	1.0	-0.9	0.7	0.4	0.1	1.0	-1.0
Median of all reaction times	0.3	0.4	0.8	-0.9	0.7	0.7	-0.5	0.6	-0.6
Reaction time omissions	0.1	0.2	0.3	-0.6	0.1	0.3	-0.3	0.5	-0.5
Reaction time false alarm rate	0.7	0.9	2.4	0.4	-0.1	-1.2	1.6	0.9	-0.9
Reaction time premature initiation rate	0.5	0.7	0.9	1.0	-0.9	-0.7	0.6	-0.9	0.9
Reaction time premature initiations	0.7	1.1	1.6	1.3	-1.1	-0.9	0.6	-1.1	1.1
Std. dev. reaction times	0.3	0.4	0.8	-0.6	0.1	0.1	0.6	0.9	-0.9
Reaction time trials completed	0.1	0.1	0.3	0.5	-0.3	-0.3	-0.1	-0.4	0.4
Reaction time trials AUC	0.1	0.1	0.3	0.5	-0.3	-0.3	-0.1	-0.4	0.4
Run reversals in cocaine runway, females	0.3	0.2	0.8	-0.0	0.3	-0.3	0.9	0.5	-0.5
Run reversals in cocaine runway, males	0.7	0.7	1.4	0.4	-0.3	-1.1	1.2	0.7	-0.7
Latency to leave start box in cocaine runway	0.3	0.3	0.7	-0.7	0.3	0.9	-0.5	0.1	-0.1
Latency to leave start box in cocaine runway, F	0.6	0.7	2.0	-1.1	0.2	1.4	-0.8	-0.1	0.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.2	-0.1	0.1
Std. dev. time between licks in bursts	0.2	0.3	0.5	0.5	-0.7	-0.6	0.6	-0.3	0.3
Total sessions with >9 infusions	0.4	0.4	0.7	0.8	-0.4	-0.7	0.4	-0.7	0.7
Short access day 1 total inactive lever presses	0.2	0.2	0.3	0.5	-0.5	-0.3	0.1	-0.5	0.5
Short access day 10 total inactive lever presses	0.3	0.3	0.9	-0.4	0.6	0.7	-1.0	-0.1	0.2
Short access day 1 total infusions	0.7	0.7	2.2	0.7	0.2	-1.2	1.5	0.4	-0.4
Short access day 10 total infusions	1.8	2.0	4.4	2.0	-0.9	-2.1	1.4	-0.7	0.7
Short access total infusions	1.0	1.1	2.8	1.1	-0.4	-1.5	1.7	-0.0	-0.0
Short access day 1 locomotion	0.2	0.3	0.4	0.3	0.4	-0.6	0.6	0.5	-0.5
Short access day 10 total locomotion	0.2	0.2	0.7	-0.2	0.9	0.2	-0.3	0.4	-0.4
Short access total locomotion	0.2	0.2	0.3	0.4	0.5	-0.5	0.4	0.2	-0.2
One hour access (0.3 mA shock)	2.1	2.5	4.6	1.9	-1.2	-2.2	2.0	-0.7	0.7
Compulsive drug intake	0.7	0.7	1.6	-0.8	-0.1	1.3	-1.2	-0.5	0.5
One hour access (shock baseline)	2.0	2.3	5.3	2.0	-0.8	-2.3	1.9	-0.4	0.4
Social response proportion	2.0	2.2	4.5	0.4	-1.4	0.7	-1.2	-2.1	2.1
Social responses	1.2	1.6	3.0	0.9	-1.6	-0.3	-0.2	-1.7	1.7
Social time	1.3	1.8	5.1	0.6	-2.2	-0.2	0.4	-1.6	1.6
Soleus weight	2.8	8.3	13.8	2.9	-3.4	-1.4	-0.0	-3.7	3.7
Bone: stiffness	0.9	1.4	2.9	0.8	-1.1	0.1	-0.8	-1.7	1.7
Tibialis anterior weight	7.2	24.7	38.0	5.8	-6.2	-5.0	3.9	-4.3	4.2
Time to tail flick, vehicle, before self-admin	4.7	4.8	8.1	2.4	-2.8	-1.8	1.0	-2.3	2.3
Time to tail flick, vehicle, after self-admin	0.9	1.0	2.5	0.9	-1.1	-1.1	1.6	-0.3	0.3
Time to tail flick, test, before self-admin	0.4	0.4	0.9	-0.2	-1.0	0.4	0.5	-0.6	0.6
Time to tail flick, test, after self-admin	0.2	0.2	0.2	-0.2	-0.5	0.4	-0.4	-0.4	0.5
Delta time to tail flick, vehicle, before/after SA	1.3	1.3	2.7	-1.0	0.8	0.2	0.8	1.6	-1.6
Delta time to tail flick, test, before/after SA	0.3	0.3	0.9	0.7	-0.1	-1.0	0.3	0.1	-0.1
Tibia length	1.0	2.9	7.2	-1.8	0.7	2.5	-2.7	-0.4	0.4
Ambulatory time before self-admin	2.1	2.2	3.6	-1.6	1.9	1.4	-1.2	1.3	-1.3
Ambulatory time after self-admin	0.8	0.8	2.4	-0.4	0.0	1.1	-1.6	-0.8	0.8
Bone: tissue strength	2.2	2.1	3.3	-1.8	1.6	1.6	-1.3	1.2	-1.1
Total heroin consumption	4.3	5.1	9.5	2.2	-2.4	-1.0	-0.0	-3.1	3.1
Bone: trabecular number	3.3	5.2	8.6	2.6	-2.9	-2.4	1.6	-2.0	1.9
Bone: trabecular spacing	0.3	0.4	1.1	-0.4	1.1	0.4	-0.4	0.6	-0.6
Bone: trabecular thickness	0.1	0.1	0.5	0.1	-0.7	-0.2	0.4	-0.1	0.1
Bone: trabecular tissue density	2.0	2.8	4.0	-2.0	2.0	1.6	-0.8	1.7	-1.7
Water consumed over 24 hours	0.8	0.9	2.2	-0.8	0.4	1.4	-1.5	-0.4	0.4
Number of responses in last shaping day	0.7	0.7	1.4	-0.3	1.1	-0.3	0.2	1.2	-1.2