Mnt

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	intron excision ratio	chr10_60207564_60209659	0.02	0.02	9.5e-04	0.01	0.01	0.01	0.01	2.6e-03	2.1e-03	1.4e-02	6.2e-03
2	NAcc	isoform ratio	NM_001105807.2	0.02	0.02	5.2e-03	0.01	0.01	0.01	0.01	4.4e-03	6.7e-03	1.1e-02	9.4e-03
3	NAcc	gene expression	Mnt	0.13	0.08	5.3e-13	0.08	0.07	0.06	0.08	4.7e-12	1.6e-10	2.1e-09	6.1e-12
4	IC	gene expression	Mnt	0.08	0.07	9.5e-03	0.06	0	0.05	0	2.5e-03	2.0e-01	5.4e-03	2.8e-01
5	PL	intron excision ratio	chr10_60204937_60209659	0.02	0.01	8.7e-03	0	0.01	0	0	1.5e-01	5.2e-02	1.2e-01	2.2e-01
6	LHb	intron excision ratio	chr10_60204937_60209659	0.33	0.21	6.1e-03	0.03	0.01	0.03	0.05	8.5e-02	1.6e-01	6.0e-02	2.6e-02
7	NAcc	mRNA stability	Mnt	0.01	0.01	7.6e-03	0.02	0.01	0.01	0.01	1.3e-03	2.0e-03	6.9e-03	1.7e-03
8	PL	mRNA stability	Mnt	0.06	0.05	3.2e-05	0.05	0.04	0.04	0.05	4.3e-06	9.7e-05	8.3e-05	8.7e-06
9	LHb	intron excision ratio	chr10_60207564_60209659	0.39	0.25	7.6e-03	0.07	0.03	0.03	0.05	1.2e-02	8.2e-02	6.2e-02	2.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	3.5	6.1	9.4	-3.1	2.8	-3.0	-3.0	2.2	2.7	-1.3	-1.2	-2.1
Area under the delay curve	0.7	0.8	1.7	1.1	-1.3	1.2	1.0	-0.7	-0.5	0.2	0.8	0.4
BMI with tail	1.0	3.5	5.0	-2.2	2.1	-2.1	-2.1	2.1	1.8	-1.8	-1.1	-1.1
BMI without tail	0.8	2.5	7.7	-1.6	1.2	-1.2	-1.1	0.5	2.8	0.2	0.8	-2.7
Body weight	1.1	4.6	14.6	-1.8	1.1	-1.1	-1.2	-0.2	3.6	1.4	2.1	-3.8
Weight adjusted by age	0.8	1.2	2.7	-1.1	0.9	-0.9	-1.1	1.5	1.0	-1.6	-0.9	-0.4
Bone surface	3.7	6.7	10.0	-3.1	3.0	-3.1	-3.2	2.6	2.3	-2.0	-1.7	-1.6
Bone volume	3.8	6.8	10.0	-3.2	3.1	-3.1	-3.2	2.7	2.3	-2.0	-1.7	-1.6
Breakpoint value in progressive ratio session	0.8	1.0	3.1	-1.0	0.8	-0.7	-0.8	0.3	1.8	0.0	0.4	-1.7
Number of licking bursts	0.2	0.3	0.5	0.7	-0.7	0.6	0.7	-0.5	-0.6	0.3	0.2	0.5
Context. condit. distance diff. score	1.0	1.2	2.1	-1.4	1.1	-1.1	-1.4	0.9	1.4	-0.4	-0.2	-1.2
Locomotion velocity, session 1	2.0	2.1	4.4	-1.8	1.6	-1.6	-1.3	0.7	2.1	0.2	0.0	-2.0
Locomotion distance, session 1	0.6	0.7	1.5	-1.0	1.1	-1.2	-0.8	0.8	0.7	-0.3	-0.8	-0.5
Locomotion velocity, session 2	0.6	0.7	1.3	-1.1	1.1	-1.1	-0.8	0.6	0.9	-0.2	-0.5	-0.8
Locomotion distance, session 2	1.4	2.0	3.4	-1.7	1.7	-1.8	-1.6	1.4	1.2	-0.8	-1.1	-0.9
Locomotion velocity, session 3	4.6	5.3	8.6	2.7	-2.6	2.7	2.9	-2.6	-1.9	2.0	1.6	1.1
Locomotion distance, session 3	0.1	0.1	0.3	0.0	0.2	-0.1	-0.1	0.3	-0.3	-0.4	-0.6	0.4
Stereotopy head waving bouts, day 3	0.3	0.4	1.3	0.2	-0.2	0.3	0.5	-0.8	0.4	1.1	0.6	-0.6
Stereotopy head waving duration, day 3	0.1	0.1	0.3	0.3	-0.1	0.3	0.6	-0.3	-0.5	0.4	-0.3	0.5
Locomotion velocity, session 7	1.1	1.2	2.0	-1.2	1.1	-1.1	-1.3	1.4	0.7	-1.4	-0.9	-0.3
Locomotion distance, session 7	2.1	2.6	3.8	-1.8	1.6	-1.6	-2.0	1.9	1.4	-1.9	-1.2	-0.7
Stereotopy head waving bouts, day 7	0.7	0.8	1.4	-1.1	1.1	-1.0	-0.9	0.3	1.2	0.3	-0.3	-1.1
Stereotopy head waving duration, day 7	1.0	1.2	2.3	-1.4	1.5	-1.4	-1.2	0.8	1.1	-0.2	-0.8	-0.9
Locomotion velocity, session 8	0.4	0.5	0.9	-0.8	0.9	-0.9	-0.9	0.7	0.4	-0.3	-0.7	-0.2
Locomotion distance, session 8	1.8	2.6	4.9	-2.0	1.6	-1.7	-1.9	1.1	2.2	-0.3	-0.3	-1.9
Degree of sensitization distance	1.0	1.0	2.3	-1.2	0.8	-0.8	-1.1	0.8	1.5	-0.6	0.1	-1.1
Degree of sensitization stereotypy	0.9	1.0	1.8	-1.2	1.2	-1.1	-1.1	0.5	1.3	0.1	-0.3	-1.3
Conditioned locomotion	0.3	0.4	1.1	0.7	-0.3	0.4	0.7	-0.5	-1.0	0.4	-0.3	0.9
Cocaine response after cond. corrected	0.1	0.2	0.4	-0.0	-0.0	-0.0	-0.0	-0.4	0.5	0.6	0.5	-0.7
Cocaine response after cond. not corrected	0.2	0.3	0.9	-0.4	0.4	-0.3	-0.3	-0.2	0.9	0.4	0.4	-0.9
Cocaine response before conditioning	0.9	1.0	1.6	-1.2	1.3	-1.1	-1.1	0.9	1.1	-0.7	-0.5	-0.9
Saline control response	0.7	0.9	1.7	-1.0	1.1	-0.9	-0.9	1.2	0.3	-1.3	-1.1	0.1
Bone: connectivity density	5.4	8.5	13.1	-3.5	3.4	-3.5	-3.6	2.7	3.0	-1.7	-1.7	-2.2
Bone: cortical apparent density	0.3	0.4	1.3	0.4	-0.2	0.3	0.3	0.2	-1.0	-0.6	-0.7	1.1
Bone: cortical area	1.4	2.1	3.8	1.8	-1.9	1.8	1.7	-1.2	-1.3	0.4	1.2	1.0
Bone: cortical porosity	0.2	0.2	0.6	-0.5	0.3	-0.4	-0.6	0.3	0.8	-0.1	0.1	-0.7
Bone: cortical porosity	0.0	0.0	0.1	-0.0	-0.2	0.0	-0.1	-0.1	0.4	0.1	0.3	-0.4
Bone: cortical thickness	5.4	8.9	14.0	3.6	-3.7	3.6	3.4	-3.2	-2.3	2.2	2.7	1.4
Bone: cortical thickness	1.8	2.1	3.6	1.5	-1.7	1.6	1.5	-1.8	-0.5	1.5	1.9	0.0
Bone: cortical tissue density	0.2	0.3	0.9	0.3	-0.1	0.1	0.2	0.3	-0.8	-0.5	-0.7	0.9
Condit. Reinf. active minus inactive responses	0.4	0.4	0.7	0.6	-0.7	0.6	0.8	-0.8	-0.1	0.7	0.8	-0.2
Condit. Reinf. active-inactive response ratio	3.3	3.6	5.4	1.9	-2.1	2.1	2.1	-2.3	-0.6	2.1	2.3	-0.2
Condit. Reinf. active responses	0.2	0.3	0.5	-0.6	0.6	-0.7	-0.5	0.6	0.4	-0.5	-0.4	-0.3
Condit. Reinf. inactive responses	4.4	5.3	8.4	-2.3	2.5	-2.6	-2.4	2.9	0.7	-2.7	-2.8	0.2
Incentive salience index mean	0.4	0.4	0.9	0.5	-0.6	0.4	0.7	-0.9	0.1	1.0	0.9	-0.5
Condit. Reinf. lever presses	0.4	0.6	1.9	-0.3	0.1	-0.3	-0.1	-0.6	1.1	1.0	1.0	-1.4
Condit. Reinf. active minus inactive responses	0.6	0.8	1.4	-1.0	0.9	-0.9	-1.2	1.2	0.6	-1.2	-0.6	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.2	-0.4	0.3	0.1	-0.3	0.1	0.2	0.6	-0.2
Condit. Reinf. active responses	1.9	2.6	5.0	-1.6	1.6	-1.6	-1.8	2.1	0.6	-2.2	-1.6	-0.0
Condit. Reinf. inactive responses	4.2	5.4	10.1	-2.2	2.5	-2.4	-2.2	3.0	0.6	-3.2	-2.7	0.4
Condit. Reinf. lever presses	0.6	0.9	1.9	-0.1	0.6	-0.4	-0.5	1.0	-0.9	-1.4	-1.4	1.3
Condit. Reinf. lever reinforcers received	2.0	2.7	5.7	-1.6	1.6	-1.6	-1.8	2.2	0.5	-2.4	-1.7	0.1
Conditioned reinforcement - actives	1.4	2.4	3.5	-1.8	1.8	-1.7	-1.6	1.9	1.1	-1.8	-1.4	-0.6
Conditioned reinforcement - inactives	0.4	0.6	1.4	-0.8	0.8	-0.7	-0.7	1.0	0.7	-1.2	-0.5	-0.3
Conditioned locomotion	0.2	0.3	0.9	0.3	-0.1	0.1	0.2	0.2	-0.8	-0.7	-0.4	1.0
Patch foraging indifference point 0 sec	0.2	0.3	0.6	-0.6	0.8	-0.8	-0.7	0.4	0.4	-0.3	-0.4	-0.3
Patch foraging indifference point AUC	0.3	0.4	0.9	0.1	-0.1	-0.0	-0.2	0.6	-0.7	-0.9	-0.8	0.9
Delay disc. indifference point, 0s delay	0.2	0.3	0.4	-0.5	0.5	-0.5	-0.6	0.6	0.5	-0.5	-0.4	-0.4
Delay disc. indifference point, 16s delay	0.6	0.7	1.3	1.0	-1.2	1.2	0.9	-0.4	-0.7	-0.3	0.6	0.7
Delay disc. indifference point, 2s delay	0.5	0.6	1.0	1.0	-1.0	1.0	0.9	-0.7	-0.5	0.4	0.7	0.3
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.4	-0.5	0.5	0.4	-0.1	-0.2	-0.3	0.3	0.2
Delay disc. indifference point, 4s delay	0.5	0.5	1.1	0.8	-1.0	1.0	0.7	-0.7	0.1	0.4	1.0	-0.2
Delay disc. indifference point, 8s delay	0.5	0.6	1.3	0.9	-1.1	1.1	0.7	-0.7	-0.2	0.4	0.8	0.0
Indifference point function ln k	0.4	0.7	1.4	-1.0	1.1	-0.9	-0.8	0.4	1.2	0.1	-0.2	-1.1
Indifference point function log k	0.4	0.7	1.4	-1.0	1.1	-0.9	-0.8	0.4	1.2	0.1	-0.2	-1.1
Patch foraging total patch changes 0 sec	0.2	0.4	0.8	-0.7	0.9	-0.9	-0.9	0.6	0.4	-0.4	-0.6	-0.2
Patch foraging total patch changes 12 sec	0.4	0.5	0.8	0.8	-0.8	0.7	0.8	-0.9	-0.4	0.8	0.6	0.2
Patch foraging total patch changes 18 sec	0.2	0.4	0.7	0.7	-0.9	0.7	0.5	-0.6	-0.4	0.4	0.8	0.3
Patch foraging total patch changes 24 sec	0.3	0.4	0.7	0.9	-0.8	0.7	0.6	-0.5	-0.9	0.2	0.2	0.8
Patch foraging total patch changes 6 sec	0.2	0.3	0.9	0.1	0.1	-0.2	-0.3	0.5	-0.8	-0.7	-0.8	0.9
Patch foraging time to switch 0 sec	1.2	2.5	4.4	1.4	-1.6	1.5	1.6	-2.1	-0.5	2.0	2.1	-0.1
Patch foraging water rate 0 sec	0.5	1.0	2.7	-0.6	0.9	-0.9	-0.8	1.3	-0.2	-1.3	-1.6	0.6
Patch foraging water rate 12 sec	0.0	0.1	0.2	-0.2	0.1	-0.1	-0.2	0.3	0.5	-0.3	0.0	-0.4
Patch foraging water rate 18 sec	2.4	3.7	5.1	-2.2	2.3	-2.2	-2.1	2.1	1.6	-1.6	-1.7	-1.0
Patch foraging water rate 24 sec	0.3	0.4	1.0	-0.5	0.8	-0.7	-0.5	0.8	-0.0	-0.8	-1.0	0.2
Patch foraging water rate 6 sec	0.1	0.2	0.4	0.4	-0.2	0.2	0.3	0.1	-0.6	-0.4	-0.5	0.7
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.6	0.8	-0.7	0.7	0.5	-0.1	-1.2	-0.4	-0.4	1.3
Distance traveled before self-admin	2.1	2.8	4.6	2.1	-2.1	2.1	2.1	-1.2	-1.8	0.3	0.6	1.5
Distance traveled after self-admin	0.2	0.3	0.8	0.7	-0.7	0.7	0.9	-0.3	-0.3	0.0	0.3	0.3
Extensor digitorum longus weight	4.8	18.8	27.4	-5.1	5.2	-5.2	-5.0	4.8	3.0	-3.6	-4.0	-1.7
Bone: elastic displacement	0.4	0.4	1.3	0.6	-0.5	0.5	0.5	-0.1	-1.1	-0.2	-0.3	1.1
Bone: elastic work	4.5	5.8	8.6	2.9	-2.8	2.8	2.8	-2.6	-2.2	1.9	1.8	1.5
Bone: endosteal estimation	0.3	0.7	1.3	-0.8	1.1	-0.8	-0.7	1.1	0.3	-1.1	-1.0	-0.0
Bone: endosteal perimeter	1.5	3.2	6.4	-1.7	1.9	-1.8	-1.7	2.4	0.6	-2.5	-2.0	0.2
Epididymis fat weight	6.1	20.9	33.5	-5.7	4.9	-5.0	-5.3	3.8	5.8	-2.2	-1.2	-4.7
Delta time in closed arm before/after self-admin	0.3	0.3	0.7	0.5	-0.3	0.3	0.3	0.2	-0.8	-0.3	-0.7	0.8
Delta time in open arm before/after self-admin	0.6	0.6	1.3	-1.0	0.8	-0.8	-1.1	0.6	0.9	-0.5	0.1	-0.7
Diff in mean of infusions in LGA sessions	0.7	0.9	2.1	-1.0	1.0	-0.9	-0.9	0.3	1.4	0.3	0.1	-1.4
Delay discount exponential model param	0.6	0.7	1.5	-1.1	1.2	-1.2	-0.9	0.7	0.4	-0.3	-0.8	-0.3
Extinction: sum of active levers before priming	3.1	3.4	4.5	-2.1	2.0	-2.0	-2.0	2.1	1.7	-1.9	-1.5	-1.0
Active lever presses in extinction session 6	2.6	2.6	3.5	-1.9	1.8	-1.7	-1.8	1.7	1.7	-1.4	-1.1	-1.2
Bone: final force	1.3	2.0	3.5	1.4	-1.5	1.6	1.4	-1.8	-0.1	1.6	1.9	-0.4
Bone: final moment	1.0	1.6	2.6	1.3	-1.4	1.4	1.2	-1.6	-0.2	1.4	1.6	-0.2
Food consumed during 24 hour testing period	0.3	0.4	0.7	-0.7	0.7	-0.7	-0.8	0.5	0.7	-0.3	-0.3	-0.5
Glucose	2.8	4.3	6.7	2.6	-2.5	2.5	2.4	-1.6	-2.5	0.6	1.0	2.1
Heart weight	0.9	1.3	3.5	-1.2	0.9	-0.9	-1.1	0.1	1.9	0.6	0.5	-1.9
Delay discount hyperbolic model param	0.8	0.9	1.9	-1.2	1.4	-1.3	-1.0	0.9	0.4	-0.5	-0.9	-0.2
Intermittent access intake day 1-15 change	0.6	1.3	3.5	0.1	0.0	-0.1	-0.4	1.0	-1.5	-1.7	-1.4	1.9
Intermittent access intake escalation	0.7	1.4	3.5	0.1	0.1	-0.1	-0.5	1.1	-1.5	-1.9	-1.4	1.9
Intermittent access intake escalation 2	1.1	1.3	4.4	0.4	-0.1	0.1	-0.1	0.7	-1.9	-1.2	-1.3	2.1
Intermitt. access day 1 inactive lever presses	0.4	1.4	3.6	1.4	-1.1	1.2	0.9	-0.2	-1.8	-0.7	-0.5	1.9
Intermitt. access day 15 inactive lever presses	0.4	0.8	1.6	0.9	-0.8	0.8	0.7	0.3	-1.1	-1.0	-0.9	1.3
Intermitt. access escalation Index	0.7	1.0	2.7	-0.0	-0.4	0.2	0.3	-1.1	1.0	1.6	1.5	-1.3
Intermittent access day 1 total infusions	0.1	0.1	0.4	-0.2	0.1	0.0	0.1	0.4	0.5	-0.6	-0.1	-0.3
Intermittent access day 15 total infusions	0.9	1.3	4.1	-0.7	0.8	-0.7	-0.9	1.5	-0.2	-2.0	-1.5	0.8
Intermittent access terminal intake (last 3 days)	1.0	1.4	2.7	-1.1	1.2	-1.1	-1.2	1.5	0.3	-1.7	-1.3	0.1
Intermittent access total infusions	0.6	0.7	2.6	-0.6	0.6	-0.5	-0.6	1.2	0.2	-1.6	-1.0	0.2
Intermittent access day 1 locomotion	0.2	0.2	0.5	0.4	-0.4	0.6	0.7	-0.3	0.5	-0.1	0.5	-0.5
Intermittent access day 15 total locomotion	0.1	0.3	1.0	0.3	-0.2	0.3	0.3	0.4	-0.5	-1.0	-0.4	0.7
Intermittent access total locomotion	0.2	0.2	1.2	-0.1	0.2	0.1	-0.0	0.6	0.1	-1.1	-0.4	0.1
Intermittent access standard deviation	1.3	2.6	7.4	-0.6	0.9	-0.8	-1.1	2.0	-0.9	-2.7	-2.4	1.6
Left kidney weight	1.9	9.0	13.9	3.0	-3.3	3.3	3.3	-3.6	-1.1	3.3	3.7	0.1
Right kidney weight	1.9	8.4	15.5	2.6	-3.1	3.1	3.1	-3.6	-0.2	3.4	3.9	-0.8
Cocaine induced anxiety	0.1	0.1	0.4	0.2	-0.1	0.1	-0.2	0.0	-0.7	-0.1	-0.4	0.6
Post-drug Anxiety	0.3	0.3	1.0	-0.3	0.1	-0.2	-0.2	-0.5	0.5	1.0	0.5	-0.8
Baseline Anxiety	0.6	0.7	2.2	-0.8	0.5	-0.6	-0.3	-0.1	1.3	0.7	0.5	-1.5
Tail length	1.2	4.8	12.4	-0.2	-0.4	0.4	0.3	-2.0	2.8	3.1	3.1	-3.5
Length with tail	1.4	6.1	14.6	0.3	-0.9	1.0	0.7	-2.6	2.5	3.7	3.8	-3.4
Length without tail	0.4	1.4	3.9	-0.5	0.1	-0.1	-0.3	-0.7	1.6	1.5	1.6	-2.0
Times rat made contact with spout	1.6	1.8	3.0	1.4	-1.4	1.6	1.5	-1.6	-0.4	1.4	1.7	-0.1
Lifetime Intake	0.5	0.6	2.0	-0.5	0.6	-0.4	-0.5	1.1	0.4	-1.4	-0.9	0.0
Liver weight, left	2.8	4.7	14.6	-1.2	0.4	-0.4	-0.5	-1.1	3.4	2.2	2.8	-3.8
Liver weight, right	2.4	4.2	13.9	-1.5	0.9	-0.9	-1.1	-0.4	3.5	1.5	2.0	-3.7
Locomotor activity	0.1	0.2	0.8	-0.5	0.2	-0.1	-0.3	0.6	0.6	-0.9	0.1	-0.3
Locomotor testing distance	0.0	0.1	0.2	-0.3	0.2	-0.1	-0.2	0.3	0.2	-0.5	0.0	-0.0
Locomotor testing rearing	0.6	1.2	2.7	-1.1	1.1	-1.1	-1.1	1.5	-0.0	-1.6	-1.1	0.5
Locomotion in novel chamber	1.6	2.1	6.2	0.8	-0.2	0.3	0.4	0.8	-2.1	-1.7	-1.8	2.5
Locomotion in novel chamber post-restriction	0.4	0.6	1.3	-0.6	0.9	-0.9	-1.0	0.8	-0.2	-0.8	-1.1	0.4
Fecal boli incidents, locomotor time 1	0.1	0.1	0.7	0.3	-0.2	0.2	0.2	-0.6	-0.1	0.8	0.3	-0.1
Change in fecal boli incidents, locomotor task	0.5	0.5	0.7	0.7	-0.7	0.8	0.7	-0.8	-0.4	0.7	0.8	0.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.4	0.3	-0.5	-0.5	0.4	0.2	-0.3	-0.5	-0.0
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.2	0.3	-0.3	-0.3	0.1	0.4	0.1	-0.2	-0.5
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.3	0.3	-0.3	-0.3	0.3	0.3	-0.1	-0.4	-0.3
Rest time, locomotor task time 1	0.2	0.2	0.8	0.4	-0.2	0.3	0.4	-0.1	-0.9	0.0	-0.3	0.8
Distance moved, locomotor task time 1	0.1	0.2	0.3	-0.4	0.4	-0.4	-0.5	0.5	0.4	-0.5	-0.2	-0.2
Vertical activity count, locomotor time 1	0.3	0.8	1.1	-1.0	1.1	-1.0	-1.1	0.9	0.7	-0.7	-0.7	-0.4
Time >=10cm from walls, locomotor time 2	0.3	0.4	0.9	0.9	-0.9	0.8	0.7	-0.6	-0.3	0.3	0.5	0.2
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.2	-0.2	0.2	0.2	-0.1	0.1	-0.1	0.3	-0.2
Total resting periods, locomotor time 2	0.0	0.1	0.1	-0.2	0.2	-0.1	-0.1	0.2	0.4	-0.3	0.1	-0.4
Rest time, locomotor task time 2	0.1	0.2	0.6	-0.4	0.2	-0.2	-0.2	0.6	-0.1	-0.8	-0.4	0.3
Distance moved, locomotor task time 2	0.2	0.2	0.5	0.1	0.1	-0.2	-0.3	0.3	-0.5	-0.5	-0.7	0.6
Vertical activity count, locomotor time 2	0.1	0.2	0.6	0.5	-0.4	0.3	0.3	-0.7	-0.3	0.8	0.2	0.1
Light reinforcement 1	0.0	0.1	0.3	-0.3	0.3	-0.3	-0.5	0.3	-0.2	-0.3	-0.2	0.3
Light reinforcement 2	2.0	3.0	4.4	2.0	-2.1	2.0	2.1	-2.0	-1.0	1.6	1.7	0.5
Bone: marrow area	0.3	0.7	1.2	-0.8	1.1	-0.8	-0.6	1.0	0.3	-1.1	-0.9	-0.0
Bone: maximum diameter	0.3	0.6	2.5	-0.3	0.4	-0.4	-0.4	1.0	-0.3	-1.6	-1.0	0.7
Bone: maximum force	1.2	2.1	3.2	1.5	-1.6	1.7	1.5	-1.8	-0.4	1.5	1.8	-0.1
Bone: maximum moment	0.9	1.6	2.4	1.4	-1.5	1.5	1.4	-1.5	-0.5	1.2	1.4	0.1
Mean time between licks in bursts	0.2	0.5	1.1	-0.0	-0.1	0.2	0.2	-0.6	0.8	1.0	1.0	-1.1
Mean num. licks in bursts	0.2	0.4	1.1	0.3	-0.4	0.5	0.4	-0.7	0.4	0.8	1.1	-0.6
Cd content in liver	1.7	1.9	4.3	-1.2	1.2	-1.3	-1.4	1.9	0.3	-2.1	-1.5	0.3
Co content in liver	0.1	0.1	0.3	0.3	-0.5	0.5	0.4	-0.1	0.0	-0.4	0.3	-0.0
Cu content in liver	0.7	0.8	1.6	1.1	-1.0	1.0	1.2	-0.8	-0.9	0.3	0.5	0.6
Fe content in liver	0.4	0.4	1.1	-0.0	-0.2	0.1	0.2	-0.7	0.7	1.1	1.0	-0.9
K content in liver	0.9	0.9	1.8	0.6	-0.8	0.8	0.7	-1.2	0.4	1.3	1.3	-0.8
Mg content in liver	0.2	0.2	0.7	-0.4	0.4	-0.4	-0.4	0.6	0.1	-0.8	-0.6	0.1
Mn content in liver	0.6	0.6	1.3	-0.7	1.0	-0.9	-0.8	0.9	0.1	-0.7	-1.1	0.2
Na content in liver	2.4	2.6	3.8	1.9	-1.9	1.9	2.0	-1.7	-1.2	1.2	1.5	0.7
Rb content in liver	4.1	4.7	7.4	-2.4	2.4	-2.5	-2.7	2.5	1.5	-2.1	-2.0	-0.8
Se content in liver	0.5	0.6	0.9	0.9	-0.9	0.8	0.9	-0.8	-0.6	0.6	0.5	0.3
Sr content in liver	1.4	1.2	1.8	-1.2	1.3	-1.2	-1.1	1.3	0.6	-1.0	-1.3	-0.3
Zn content in liver	0.1	0.1	0.5	-0.2	0.1	-0.0	0.0	-0.2	0.6	0.3	0.5	-0.7
Bone: minimum diameter	0.7	1.2	2.0	1.2	-1.4	1.4	1.4	-1.1	-0.4	0.7	1.4	0.2
Time in familiar zone, hab. session 1	1.5	1.5	2.9	-1.1	1.3	-1.2	-1.3	1.5	0.1	-1.4	-1.7	0.4
Time in novel zone, hab. session 1	1.2	1.2	2.5	1.0	-1.2	1.2	1.0	-1.4	-0.0	1.3	1.6	-0.3
Total zone transitions, hab. session 1	2.4	3.4	5.1	-1.9	2.1	-2.1	-2.0	2.2	0.7	-1.9	-2.3	0.0
Total locomotion distance, hab. session 1	0.7	1.0	1.4	-1.1	1.1	-1.2	-1.1	1.2	0.7	-0.8	-1.0	-0.3
Locomotion velocity, hab. session 1	0.7	1.0	1.7	-1.1	1.2	-1.3	-1.0	1.2	0.6	-0.9	-1.2	-0.2
Time in familiar zone, hab. session 2	2.0	2.1	2.9	-1.6	1.7	-1.7	-1.6	1.7	0.9	-1.4	-1.5	-0.4
Time in novel zone, hab. session 2	4.7	4.8	6.6	2.5	-2.6	2.6	2.5	-2.5	-1.4	2.1	2.1	0.6
Total zone transitions, hab. session 2	0.9	1.1	2.0	-1.3	1.3	-1.4	-1.2	1.0	1.0	-0.4	-0.8	-0.7
Total locomotion distance, hab. session 2	0.1	0.1	0.3	-0.2	0.2	-0.3	0.1	-0.1	0.3	0.6	0.1	-0.4
Locomotion velocity, hab. session 2	0.1	0.1	0.3	-0.1	0.1	-0.2	0.2	-0.2	0.2	0.6	0.1	-0.3
Novel to familiar place preference ratio	0.2	0.3	0.7	0.2	-0.1	0.2	-0.0	0.4	-0.7	-0.9	-0.5	0.9
Novelty place preference	0.1	0.1	0.2	0.2	-0.2	0.2	0.0	0.1	-0.4	-0.4	-0.1	0.4
Time in novel zone, NPP test	0.0	0.0	0.2	-0.1	0.1	-0.0	-0.2	0.3	-0.1	-0.5	-0.1	0.2
Total zone transitions, NPP test	1.4	2.0	2.9	-1.5	1.6	-1.7	-1.6	1.7	0.7	-1.3	-1.6	-0.2
Total locomotion distance, NPP test	0.4	0.6	1.3	-0.6	0.7	-0.8	-0.5	1.1	-0.0	-1.0	-1.2	0.4
Locomotion velocity, NPP test	0.4	0.5	1.4	-0.2	0.4	-0.5	-0.2	0.9	-0.5	-1.0	-1.2	0.8
Intraocular pressure	1.5	2.1	6.7	-0.5	0.5	-0.7	-0.8	1.9	-0.9	-2.6	-2.0	1.6
Delta distance traveled before/after self-admin	1.6	1.7	3.1	-1.6	1.5	-1.4	-1.3	0.9	1.8	-0.3	-0.2	-1.6
Delta ambulatory time before/after self-admin	1.2	1.4	2.4	-1.5	1.5	-1.4	-1.2	0.9	1.5	-0.2	-0.4	-1.3
Parametrial fat weight	5.0	11.8	20.9	-4.4	3.9	-3.8	-3.8	2.3	4.6	-0.7	-0.3	-4.1
Pavlov. Cond. lever latency	0.4	0.5	1.4	-0.5	0.8	-0.6	-0.5	0.9	-0.3	-0.8	-1.2	0.5
Pavlov. Cond. magazine entry latency	0.3	0.4	0.8	-0.1	-0.1	0.0	0.1	-0.6	0.7	0.9	0.9	-0.9
Pavlov. Cond. change in total contacts	0.6	0.6	1.0	0.9	-0.9	0.9	1.0	-0.8	-0.6	0.6	0.7	0.4
Pavlov. Cond. index score	0.4	0.6	1.3	-0.0	-0.3	0.1	0.2	-0.8	0.8	1.1	1.2	-1.1
Pavlov. Cond. latency score	0.7	0.9	2.3	0.1	-0.5	0.4	0.4	-1.0	0.9	1.3	1.5	-1.2
Pavlov. Cond. lever contacts	0.4	0.5	1.3	0.4	-0.7	0.6	0.5	-0.8	0.2	0.8	1.1	-0.5
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.2	-0.1	0.1	0.0	0.2	-0.4	-0.3	-0.3	0.4
Pavlov. Cond. intertrial magazine entries	1.0	1.2	2.7	-0.7	1.0	-0.9	-0.8	1.4	-0.3	-1.5	-1.6	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.9	-0.0	-0.2	0.1	0.2	-0.7	0.7	0.9	0.9	-0.9
Pavlov. Cond. response bias	0.2	0.2	0.5	-0.2	0.0	-0.1	-0.0	-0.3	0.6	0.5	0.6	-0.7
Pavlov. Cond. lever latency	0.7	0.9	1.9	-1.1	1.1	-1.1	-0.9	0.4	1.4	0.2	-0.2	-1.3
Pavlov. Cond. magazine entry latency	1.3	1.6	2.4	1.4	-1.5	1.6	1.3	-1.5	-0.6	1.2	1.4	0.2
Pavlov. Cond. change in total contacts	0.6	0.9	1.5	1.2	-1.2	1.2	1.1	-0.7	-1.1	0.3	0.6	0.9
Pavlov. Cond. index score	1.0	1.3	2.3	1.5	-1.4	1.4	1.2	-0.7	-1.5	0.1	0.4	1.4
Pavlov. Cond. latency score	1.2	1.6	2.8	1.6	-1.4	1.5	1.3	-0.8	-1.7	0.1	0.4	1.5
Pavlov. Cond. lever contacts	0.4	0.5	0.8	0.9	-0.9	0.9	0.7	-0.5	-0.9	0.1	0.5	0.8
Pavlov. Cond. magazine entry number	1.3	1.7	2.6	-1.5	1.6	-1.6	-1.3	1.4	0.9	-1.0	-1.3	-0.5
Pavlov. Cond. intertrial magazine entries	2.0	3.0	4.3	-2.0	2.1	-2.0	-1.8	2.0	1.2	-1.6	-1.6	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	2.1	1.4	-1.3	1.3	1.1	-0.7	-1.5	0.0	0.4	1.3
Pavlov. Cond. response bias	0.8	1.1	1.8	1.3	-1.3	1.4	1.0	-0.8	-1.0	0.3	0.9	0.8
Time in closed arm before self-admin	0.7	1.0	2.2	-1.0	1.0	-0.9	-0.7	-0.1	1.3	1.0	0.3	-1.5
Time in closed arm after self-admin	0.5	0.6	1.3	0.8	-0.7	0.8	0.9	-0.9	-0.4	1.1	0.4	0.1
Time in open arm before self-admin	2.2	2.4	4.1	2.0	-2.0	1.9	2.0	-1.0	-1.6	0.1	0.7	1.5
Time in open arm after self-admin	0.5	0.5	1.4	0.5	-0.6	0.6	0.3	0.3	-0.8	-1.2	-0.0	1.2
Bone: periosteal estimation	0.1	0.3	0.6	0.7	-0.6	0.7	0.8	-0.3	-0.4	-0.1	0.4	0.4
Bone: periosteal perimeter	0.1	0.2	1.1	0.1	-0.1	0.1	0.0	0.5	-0.3	-1.1	-0.4	0.5
Bone: post-yield work	0.3	0.4	1.2	-0.6	0.4	-0.5	-0.5	0.0	1.1	0.4	0.3	-1.1
Progressive ratio test 1 active lever presses	0.3	0.3	1.6	-0.2	0.1	-0.1	-0.1	0.8	0.4	-1.3	-0.7	-0.1
Progressive ratio test 1 breakpoint	0.3	0.4	1.8	-0.2	0.2	-0.2	-0.2	0.9	0.4	-1.3	-0.8	-0.1
Progressive ratio test 1 inactive lever presses	0.5	0.8	1.4	1.2	-1.0	1.2	1.0	-0.2	-1.0	-0.4	-0.2	1.0
Progressive ratio test 2 active lever presses	1.8	2.2	6.1	-1.2	1.1	-1.1	-1.0	2.0	1.1	-2.5	-1.8	-0.4
Progressive ratio test 2 breakpoint	1.9	2.2	6.1	-1.2	1.2	-1.1	-1.0	2.1	1.1	-2.5	-1.8	-0.4
Progressive ratio test 2 inactive lever presses	0.5	0.8	3.8	-0.2	0.1	-0.1	-0.3	1.3	0.4	-1.9	-1.2	0.1
Incentive Sensitization - Responses	1.6	2.3	5.5	-1.4	1.3	-1.2	-1.1	2.1	1.3	-2.4	-1.7	-0.6
Incentive Sensitization - Breakpoint	1.5	2.0	4.6	-1.3	1.2	-1.1	-1.0	1.9	1.2	-2.1	-1.6	-0.6
Sum of active levers in priming session hrs 5-6	1.9	1.8	4.6	-1.6	1.2	-1.2	-1.1	0.9	2.1	-0.7	0.2	-1.9
Progressive ratio	0.1	0.1	0.7	0.1	0.2	-0.1	-0.2	0.3	-0.4	-0.2	-0.9	0.4
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.2	-0.1	0.1	0.2	-0.2	-0.3	0.2	-0.2	0.2
Seeking ratio, punishment vs. effort	0.6	0.9	1.5	0.9	-1.1	1.0	1.2	-1.1	-0.5	0.9	1.2	0.2
Retroperitoneal fat weight	0.2	0.8	1.4	-1.1	0.8	-0.8	-1.2	0.9	1.2	-0.8	-0.0	-0.8
Reaction time number correct	0.0	0.1	0.2	-0.3	0.4	-0.3	-0.1	0.2	0.4	-0.3	0.0	-0.4
Reaction time mean minus median	0.1	0.3	0.7	-0.0	0.4	-0.3	-0.2	0.3	-0.8	-0.2	-0.8	0.9
Reaction time mean minus median AUC	0.6	1.5	2.8	-1.1	1.5	-1.4	-1.2	1.4	-0.1	-1.1	-1.7	0.4
Reaction time num false alarms	1.0	1.4	3.1	-0.5	0.9	-0.7	-0.7	1.4	-0.9	-1.6	-1.8	1.4
Reaction time num false alarms AUC	0.8	1.2	2.9	-0.4	0.8	-0.6	-0.6	1.3	-0.8	-1.4	-1.7	1.3
Reaction time trials correct on left	0.0	0.1	0.2	-0.3	0.4	-0.3	-0.1	0.2	0.4	-0.3	0.0	-0.4
Reaction time trials on left	0.1	0.1	0.2	-0.4	0.4	-0.3	-0.1	0.3	0.4	-0.3	-0.0	-0.4
Reaction time mean	0.1	0.1	0.2	0.2	-0.1	0.2	0.2	-0.2	-0.5	0.4	0.1	0.4
Reaction time mean AUC	0.1	0.2	0.7	0.4	-0.2	0.4	0.3	-0.2	-0.9	0.3	-0.1	0.8
Median of all reaction times	0.1	0.2	0.4	0.4	-0.4	0.5	0.4	-0.4	-0.4	0.6	0.5	0.2
Reaction time omissions	0.0	0.0	0.1	-0.3	0.3	-0.3	-0.2	0.1	-0.0	-0.0	0.0	-0.0
Reaction time false alarm rate	0.6	0.9	2.4	-0.3	0.6	-0.5	-0.6	1.0	-0.8	-1.1	-1.6	1.3
Reaction time premature initiation rate	0.6	0.8	1.1	-1.0	1.0	-1.0	-0.9	0.9	1.1	-0.5	-0.8	-0.8
Reaction time premature initiations	0.6	1.1	1.5	-1.2	1.2	-1.2	-0.9	1.1	1.1	-0.7	-0.9	-0.8
Std. dev. reaction times	0.1	0.2	0.7	0.0	0.4	-0.2	-0.1	0.2	-0.8	0.0	-0.7	0.8
Reaction time trials completed	0.1	0.1	0.2	-0.4	0.4	-0.3	-0.1	0.3	0.4	-0.3	-0.0	-0.4
Reaction time trials AUC	0.0	0.1	0.2	-0.3	0.4	-0.3	-0.1	0.3	0.3	-0.4	-0.0	-0.3
Run reversals in cocaine runway, females	0.3	0.3	1.3	-0.1	0.3	-0.3	-0.2	0.6	-0.3	-0.6	-1.2	0.4
Run reversals in cocaine runway, males	1.2	1.2	2.8	-0.8	0.9	-0.9	-0.9	1.4	-0.4	-1.7	-1.3	0.8
Latency to leave start box in cocaine runway	0.2	0.3	0.7	0.5	-0.4	0.4	0.4	-0.7	-0.3	0.8	0.4	-0.0
Latency to leave start box in cocaine runway, F	0.6	0.7	2.8	0.5	-0.4	0.5	0.5	-1.2	0.1	1.7	0.9	-0.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.4	0.0	0.0	-0.0	-0.1	0.3	-0.2	-0.6	-0.3	0.4
Std. dev. time between licks in bursts	0.2	0.3	0.4	-0.6	0.6	-0.6	-0.6	0.6	0.3	-0.4	-0.5	-0.2
Total sessions with >9 infusions	0.6	0.7	2.7	-0.6	0.7	-0.5	-0.4	1.2	0.5	-1.6	-1.0	-0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.2	0.3	-0.2	-0.2	0.4	0.2	-0.5	-0.2	-0.1
Short access day 10 total inactive lever presses	0.3	0.8	1.5	1.0	-1.0	0.9	0.9	-0.5	-1.2	0.0	0.2	1.2
Short access day 1 total infusions	0.3	0.4	1.6	0.2	-0.0	0.2	0.2	0.7	-0.5	-1.2	-0.9	0.8
Short access day 10 total infusions	0.7	0.9	4.1	-0.4	0.5	-0.2	-0.4	1.3	-0.1	-2.0	-1.0	0.6
Short access total infusions	0.3	0.3	1.4	0.1	0.1	0.1	0.1	0.7	-0.4	-1.2	-0.8	0.6
Short access day 1 locomotion	0.5	0.6	1.0	0.9	-0.7	1.0	0.9	0.1	-0.9	-1.0	-0.2	1.0
Short access day 10 total locomotion	0.2	0.4	1.0	0.7	-0.4	0.7	0.6	0.1	-0.8	-0.8	-0.2	1.0
Short access total locomotion	0.7	0.8	1.5	1.0	-0.6	1.0	1.0	0.2	-1.0	-1.2	-0.4	1.2
One hour access (0.3 mA shock)	1.7	2.0	3.4	-1.4	1.3	-1.3	-1.5	1.8	0.9	-1.8	-1.5	-0.4
Compulsive drug intake	0.7	0.8	2.4	-0.5	0.4	-0.4	-0.1	-0.6	1.3	1.3	0.8	-1.6
One hour access (shock baseline)	0.4	0.6	2.6	-0.4	0.3	-0.3	-0.6	1.2	-0.1	-1.6	-1.0	0.5
Social response proportion	1.7	1.9	6.3	-0.9	0.6	-0.6	-0.5	-0.6	2.2	1.5	1.2	-2.5
Social responses	1.1	1.4	3.3	-1.4	1.2	-1.2	-1.2	0.4	1.8	0.4	0.2	-1.8
Social time	1.3	1.8	2.8	-1.6	1.6	-1.6	-1.6	0.4	1.6	0.7	-0.1	-1.7
Soleus weight	2.1	6.2	13.9	-3.0	2.5	-2.5	-2.6	1.3	3.7	-0.1	0.3	-3.5
Bone: stiffness	0.5	0.9	2.9	-0.7	0.4	-0.4	-0.6	-0.3	1.6	0.8	0.9	-1.7
Tibialis anterior weight	7.4	25.1	37.2	-6.1	6.0	-6.0	-5.9	5.1	4.4	-3.6	-3.8	-3.0
Time to tail flick, vehicle, before self-admin	5.1	5.3	8.2	-2.9	2.9	-2.8	-2.6	2.1	2.4	-1.1	-1.5	-1.9
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.5	-0.6	0.7	-0.7	-0.6	0.3	0.4	0.2	-0.4	-0.4
Time to tail flick, test, before self-admin	0.6	0.6	2.7	-0.4	0.7	-0.7	-0.5	-0.6	0.5	1.6	0.1	-0.9
Time to tail flick, test, after self-admin	0.4	0.4	1.3	0.5	-0.5	0.5	0.7	-0.8	-0.2	1.1	0.7	-0.1
Delta time to tail flick, vehicle, before/after SA	1.1	1.1	2.9	1.2	-0.9	0.9	0.9	-0.7	-1.7	0.5	-0.0	1.6
Delta time to tail flick, test, before/after SA	0.4	0.4	1.6	0.2	-0.3	0.3	0.3	0.7	-0.5	-1.3	-0.4	0.9
Tibia length	1.1	2.9	7.0	1.0	-1.4	1.3	1.1	-2.2	0.5	2.6	2.6	-1.2
Ambulatory time before self-admin	2.9	4.3	7.1	2.6	-2.7	2.6	2.5	-1.9	-1.8	1.1	1.5	1.3
Ambulatory time after self-admin	0.7	0.9	1.7	0.7	-0.9	0.9	1.1	-1.1	0.2	1.1	1.3	-0.5
Bone: tissue strength	2.1	2.1	3.1	1.8	-1.7	1.7	1.7	-1.6	-1.1	1.3	1.1	0.6
Total heroin consumption	3.8	4.5	10.0	-2.5	2.1	-2.1	-2.2	1.4	3.2	-0.7	-0.3	-2.8
Bone: trabecular number	4.0	6.6	10.4	-3.2	3.0	-3.1	-3.2	2.3	2.6	-1.4	-1.4	-2.0
Bone: trabecular spacing	0.4	0.5	0.8	0.9	-0.8	0.9	0.8	-0.3	-0.9	-0.3	0.1	0.9
Bone: trabecular thickness	0.3	0.4	0.7	-0.8	0.8	-0.8	-0.8	0.4	0.7	0.1	-0.3	-0.6
Bone: trabecular tissue density	1.7	2.6	3.9	2.0	-1.9	1.9	1.9	-1.5	-1.7	1.0	0.8	1.3
Water consumed over 24 hours	1.0	1.4	2.8	0.9	-1.0	1.1	1.1	-1.6	0.1	1.7	1.6	-0.6
Number of responses in last shaping day	0.9	1.0	2.8	0.9	-0.7	0.8	0.7	0.3	-1.4	-1.2	-0.5	1.7