Hub : Genes

Krt77

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Krt77	0.07	0.05	4.3e-04	0.07	0.09	0.07	0.06	6.3e-04	1.6e-04	7.6e-04	9.6e-04
2	LHb	gene expression	Krt77	0.17	0.1	9.4e-04	0.15	0.17	0.15	0.14	1.7e-04	8.8e-05	2.4e-04	3.3e-04
3	Brain	gene expression	Krt77	0.12	0.11	2.7e-05	0.05	0.04	0.04	0.05	1.4e-05	4.5e-05	9.6e-05	2.8e-05
4	PL	gene expression	Krt77	0.07	0.05	9.9e-05	0.05	0.04	0.05	0.04	4.2e-06	8.6e-05	6.8e-06	2.1e-05
5	IL	gene expression	Krt77	0.26	0.16	4.7e-03	0.04	0.01	-0	-0.01	4.7e-02	1.5e-01	4.4e-01	6.8e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.1	0.1	0.3	-0.6	-0.5	0.2	0.1	0.0
Area under the delay curve	0.1	0.1	0.3	-0.6	-0.5	0.1	0.2	0.3
BMI with tail	1.5	4.8	7.0	-2.7	-2.5	2.1	1.8	1.7
BMI without tail	0.1	0.2	0.4	-0.6	-0.6	0.2	0.2	0.2
Body weight	0.2	0.7	1.6	-1.3	-1.1	0.5	0.4	0.4
Weight adjusted by age	0.2	0.2	0.5	0.0	0.2	-0.5	-0.7	-0.6
Bone surface	0.6	1.0	1.5	-1.2	-1.2	0.9	0.8	0.8
Bone volume	0.6	1.1	1.6	-1.2	-1.3	0.9	0.8	0.8
Breakpoint value in progressive ratio session	1.4	1.6	2.1	-1.0	-1.2	1.2	1.4	1.4
Number of licking bursts	0.2	0.2	0.4	-0.3	-0.3	0.2	0.6	0.6
Context. condit. distance diff. score	0.1	0.1	0.2	-0.2	-0.4	0.3	0.4	0.4
Locomotion velocity, session 1	5.7	6.1	7.0	2.6	2.6	-2.5	-2.3	-2.3
Locomotion distance, session 1	1.4	1.9	2.2	1.5	1.5	-1.3	-1.3	-1.3
Locomotion velocity, session 2	4.7	5.5	6.1	2.2	2.3	-2.5	-2.4	-2.4
Locomotion distance, session 2	1.6	2.2	2.9	1.7	1.7	-1.4	-1.4	-1.3
Locomotion velocity, session 3	5.4	6.3	7.2	2.7	2.6	-2.5	-2.4	-2.4
Locomotion distance, session 3	4.4	4.8	5.5	2.4	2.3	-2.1	-2.1	-2.1
Stereotopy head waving bouts, day 3	2.1	2.5	2.7	-1.5	-1.6	1.6	1.6	1.6
Stereotopy head waving duration, day 3	0.1	0.1	0.1	-0.3	-0.4	0.3	0.3	0.3
Locomotion velocity, session 7	0.3	0.3	0.9	0.9	0.8	-0.3	-0.2	-0.2
Locomotion distance, session 7	2.9	3.6	4.7	2.2	2.1	-1.7	-1.8	-1.7
Stereotopy head waving bouts, day 7	3.1	3.5	3.6	-1.9	-1.9	1.7	1.9	1.9
Stereotopy head waving duration, day 7	3.1	3.8	4.2	-2.0	-2.0	1.7	2.0	2.0
Locomotion velocity, session 8	0.0	0.0	0.1	0.3	0.2	-0.2	-0.0	-0.0
Locomotion distance, session 8	1.5	2.1	2.8	1.7	1.6	-1.4	-1.3	-1.3
Degree of sensitization distance	0.4	0.5	0.6	-0.6	-0.6	0.8	0.7	0.7
Degree of sensitization stereotypy	3.1	3.4	3.7	-1.9	-1.9	1.7	1.9	1.9
Conditioned locomotion	0.6	0.7	1.0	0.8	0.7	-1.0	-0.9	-0.8
Cocaine response after cond. corrected	0.1	0.1	0.1	0.2	0.3	-0.2	-0.3	-0.3
Cocaine response after cond. not corrected	0.2	0.2	0.2	0.4	0.4	-0.4	-0.4	-0.4
Cocaine response before conditioning	0.4	0.5	0.7	0.8	0.8	-0.7	-0.5	-0.5
Saline control response	0.0	0.0	0.0	0.1	0.1	0.2	0.2	0.2
Bone: connectivity density	0.1	0.1	0.2	0.2	0.3	-0.3	-0.4	-0.4
Bone: cortical apparent density	0.4	0.6	0.7	-0.8	-0.7	0.8	0.7	0.7
Bone: cortical area	0.6	1.0	1.3	-1.1	-1.1	1.0	0.8	0.8
Bone: cortical porosity	1.5	1.7	1.8	1.3	1.2	-1.3	-1.3	-1.3
Bone: cortical porosity	1.5	1.6	1.7	1.3	1.2	-1.3	-1.3	-1.3
Bone: cortical thickness	0.1	0.1	0.2	-0.4	-0.3	0.4	0.2	0.2
Bone: cortical thickness	1.9	2.2	2.5	1.4	1.5	-1.4	-1.6	-1.6
Bone: cortical tissue density	0.3	0.4	0.5	-0.6	-0.6	0.7	0.6	0.6
Condit. Reinf. active minus inactive responses	0.5	0.5	0.6	0.7	0.7	-0.8	-0.7	-0.8
Condit. Reinf. active-inactive response ratio	0.6	0.7	0.8	0.7	0.8	-0.9	-0.9	-0.9
Condit. Reinf. active responses	1.2	1.5	1.6	1.2	1.2	-1.3	-1.2	-1.2
Condit. Reinf. inactive responses	1.2	1.4	1.7	1.3	1.3	-1.1	-1.1	-1.1
Incentive salience index mean	0.1	0.1	0.1	0.3	0.3	-0.3	-0.2	-0.3
Condit. Reinf. lever presses	0.4	0.5	0.6	-0.8	-0.7	0.7	0.7	0.7
Condit. Reinf. active minus inactive responses	1.6	2.0	2.4	-1.3	-1.3	1.5	1.4	1.4
Condit. Reinf. active-inactive response ratio	0.6	0.7	0.8	-0.9	-0.9	0.8	0.8	0.8
Condit. Reinf. active responses	2.0	2.7	3.1	-1.5	-1.5	1.8	1.8	1.7
Condit. Reinf. inactive responses	0.3	0.4	0.5	-0.4	-0.4	0.7	0.7	0.7
Condit. Reinf. lever presses	0.1	0.2	0.4	0.6	0.5	-0.2	-0.2	-0.2
Condit. Reinf. lever reinforcers received	0.8	1.2	1.5	-0.8	-0.9	1.2	1.2	1.2
Conditioned reinforcement - actives	1.0	1.0	1.5	-0.6	-0.7	1.0	1.2	1.2
Conditioned reinforcement - inactives	0.0	0.0	0.1	0.3	0.3	-0.1	-0.1	-0.1
Conditioned locomotion	0.2	0.2	0.4	-0.2	-0.2	0.5	0.7	0.7
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.7	0.6	0.1	-0.2	-0.2
Patch foraging indifference point AUC	0.2	0.3	0.5	-0.4	-0.4	0.1	0.7	0.7
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	-0.1	-0.0	-0.1	-0.3	-0.1
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	-0.5	-0.5	0.3	0.2	0.4
Delay disc. indifference point, 2s delay	6.1	6.8	7.3	-2.7	-2.7	2.5	2.5	2.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.5	-0.5	0.0	0.2	0.3
Delay disc. indifference point, 4s delay	0.3	0.3	0.4	-0.6	-0.6	0.4	0.5	0.6
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	0.1	0.1	-0.4	-0.3	-0.2
Indifference point function ln k	0.1	0.1	0.2	-0.2	-0.2	0.1	-0.4	-0.4
Indifference point function log k	0.1	0.1	0.2	-0.2	-0.2	0.1	-0.4	-0.4
Patch foraging total patch changes 0 sec	0.4	0.7	1.3	1.1	1.0	-0.4	-0.7	-0.7
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	0.4	0.3	0.1	0.3	0.3
Patch foraging total patch changes 18 sec	0.1	0.2	0.4	0.6	0.6	-0.1	0.2	0.2
Patch foraging total patch changes 24 sec	0.3	0.4	0.8	-0.2	-0.3	0.5	0.9	0.9
Patch foraging total patch changes 6 sec	0.0	0.1	0.1	0.2	0.2	0.3	0.3	0.3
Patch foraging time to switch 0 sec	0.1	0.2	0.4	-0.3	-0.2	0.6	0.4	0.5
Patch foraging water rate 0 sec	0.0	0.0	0.0	-0.0	-0.1	-0.0	0.0	-0.0
Patch foraging water rate 12 sec	0.5	0.7	0.9	0.8	0.8	-0.8	-0.9	-0.9
Patch foraging water rate 18 sec	0.0	0.0	0.1	-0.1	-0.2	0.3	0.2	0.2
Patch foraging water rate 24 sec	0.4	0.6	0.7	-0.7	-0.8	0.8	0.8	0.8
Patch foraging water rate 6 sec	0.0	0.1	0.2	0.1	0.0	-0.4	-0.3	-0.2
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	0.0	0.0	0.1	-0.1	-0.1
Distance traveled before self-admin	0.1	0.1	0.2	-0.2	-0.2	0.1	0.5	0.4
Distance traveled after self-admin	0.1	0.1	0.2	0.4	0.3	-0.2	0.1	-0.0
Extensor digitorum longus weight	6.3	24.9	31.9	-5.6	-5.5	4.7	4.5	4.4
Bone: elastic displacement	4.8	5.4	6.3	2.5	2.4	-2.3	-2.2	-2.2
Bone: elastic work	3.9	5.0	5.6	2.1	2.1	-2.3	-2.4	-2.4
Bone: endosteal estimation	0.7	1.5	2.1	-1.4	-1.5	1.0	1.1	1.1
Bone: endosteal perimeter	1.0	2.2	3.0	-1.7	-1.7	1.3	1.3	1.3
Epididymis fat weight	4.4	10.3	12.4	2.9	3.0	-3.5	-3.3	-3.3
Delta time in closed arm before/after self-admin	0.4	0.4	0.6	-0.5	-0.5	0.7	0.6	0.7
Delta time in open arm before/after self-admin	6.7	6.5	7.1	2.4	2.5	-2.7	-2.6	-2.6
Diff in mean of infusions in LGA sessions	0.3	0.3	0.6	-0.8	-0.6	0.5	0.2	0.3
Delay discount exponential model param	0.2	0.3	0.5	0.7	0.6	-0.2	-0.4	-0.5
Extinction: sum of active levers before priming	1.3	1.3	1.6	-1.3	-1.3	1.2	1.0	0.9
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.4	-0.4	0.1	0.3	0.3
Bone: final force	0.2	0.3	0.7	-0.8	-0.8	0.3	0.2	0.2
Bone: final moment	0.2	0.4	0.9	-0.9	-0.9	0.3	0.3	0.3
Food consumed during 24 hour testing period	0.3	0.4	0.4	0.7	0.6	-0.6	-0.6	-0.6
Glucose	0.3	0.5	0.6	0.6	0.6	-0.6	-0.7	-0.8
Heart weight	0.0	0.0	0.1	-0.1	-0.0	-0.2	0.0	-0.1
Delay discount hyperbolic model param	0.6	0.6	0.9	1.0	0.9	-0.5	-0.7	-0.8
Intermittent access intake day 1-15 change	0.1	0.1	0.2	0.4	0.3	-0.4	-0.2	-0.2
Intermittent access intake escalation	0.0	0.0	0.0	0.2	0.1	-0.1	0.2	0.2
Intermittent access intake escalation 2	0.0	0.0	0.0	0.2	0.1	0.1	0.0	0.2
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.3	-0.4	-0.4	0.6	0.5	0.5
Intermitt. access day 15 inactive lever presses	0.6	0.7	0.8	0.9	0.9	-0.8	-0.9	-0.7
Intermitt. access escalation Index	3.4	3.0	4.1	-1.4	-1.4	2.0	1.9	1.8
Intermittent access day 1 total infusions	0.3	0.3	0.7	-0.3	-0.3	0.3	0.9	0.8
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.2	0.1	-0.0	0.5	0.4
Intermittent access terminal intake (last 3 days)	1.2	1.3	2.2	-0.6	-0.7	1.1	1.5	1.5
Intermittent access total infusions	1.4	1.5	2.7	-0.7	-0.8	1.1	1.6	1.6
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.2	0.1	-0.0	0.5	0.3
Intermittent access day 15 total locomotion	0.4	0.4	1.1	0.6	0.6	-1.0	-0.3	-0.5
Intermittent access total locomotion	0.2	0.2	0.5	-0.0	-0.1	0.2	0.7	0.6
Intermittent access standard deviation	1.1	1.1	1.7	0.9	1.0	-1.3	-1.0	-1.1
Left kidney weight	0.1	0.2	0.4	-0.6	-0.5	0.4	0.3	0.2
Right kidney weight	0.3	0.8	1.4	-1.2	-1.1	0.8	0.7	0.6
Cocaine induced anxiety	0.1	0.1	0.2	-0.3	-0.4	0.4	0.5	0.3
Post-drug Anxiety	1.8	2.0	2.5	-1.4	-1.4	1.6	1.4	1.3
Baseline Anxiety	0.0	0.0	0.1	-0.3	-0.2	0.3	0.0	0.1
Tail length	0.5	1.4	2.0	1.2	1.1	-1.4	-1.2	-1.1
Length with tail	0.3	1.0	1.7	0.7	0.8	-1.3	-1.0	-1.0
Length without tail	0.0	0.0	0.1	-0.4	-0.3	0.2	0.0	-0.0
Times rat made contact with spout	0.3	0.4	0.7	0.6	0.5	-0.8	-0.6	-0.6
Lifetime Intake	0.9	1.0	2.0	-0.5	-0.6	0.8	1.4	1.4
Liver weight, left	0.0	0.1	0.1	0.1	0.0	-0.3	-0.3	-0.3
Liver weight, right	0.0	0.0	0.1	0.2	0.1	-0.2	-0.2	-0.2
Locomotor activity	0.0	0.0	0.0	0.2	0.2	-0.1	-0.1	-0.0
Locomotor testing distance	0.4	0.7	1.0	1.0	0.9	-0.8	-0.7	-0.7
Locomotor testing rearing	0.4	0.6	1.2	0.7	0.7	-1.1	-0.8	-0.7
Locomotion in novel chamber	2.1	2.6	3.2	-1.8	-1.7	1.5	1.4	1.5
Locomotion in novel chamber post-restriction	2.0	2.4	3.4	-1.2	-1.2	1.8	1.9	1.6
Fecal boli incidents, locomotor time 1	4.3	4.7	5.5	2.2	2.2	-2.3	-1.9	-2.2
Change in fecal boli incidents, locomotor task	1.3	1.2	1.5	-1.1	-1.1	1.2	0.9	1.2
Time >=10cm from walls, locomotor time 1	0.5	0.5	0.7	0.8	0.7	-0.8	-0.4	-0.7
Bouts of movement, locomotor time 1	0.3	0.3	0.4	0.6	0.6	-0.6	-0.1	-0.5
Total resting periods, locomotor time 1	1.1	1.2	1.5	1.2	1.2	-1.1	-0.7	-1.1
Rest time, locomotor task time 1	0.6	0.7	0.9	0.8	0.8	-0.9	-0.7	-0.9
Distance moved, locomotor task time 1	2.0	2.2	3.1	-1.2	-1.3	1.8	1.5	1.6
Vertical activity count, locomotor time 1	2.9	3.1	3.4	-1.7	-1.6	1.8	1.8	1.8
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.4	0.4	0.1	0.0	-0.1
Bouts of movement, locomotor time 2	2.7	3.0	3.8	-1.6	-1.6	1.8	1.9	1.6
Total resting periods, locomotor time 2	3.3	3.5	3.9	-1.8	-1.8	1.9	2.0	1.8
Rest time, locomotor task time 2	0.2	0.2	0.6	0.4	0.4	-0.4	-0.8	-0.3
Distance moved, locomotor task time 2	0.0	0.0	0.2	-0.1	-0.0	0.4	0.2	0.0
Vertical activity count, locomotor time 2	0.2	0.3	0.5	-0.5	-0.5	0.4	0.7	0.3
Light reinforcement 1	0.1	0.1	0.2	0.2	0.2	0.4	0.4	0.5
Light reinforcement 2	0.2	0.3	0.4	0.6	0.7	-0.5	-0.5	-0.5
Bone: marrow area	0.7	1.5	2.1	-1.4	-1.5	1.0	1.1	1.1
Bone: maximum diameter	0.8	1.4	1.5	-1.2	-1.2	1.2	1.2	1.2
Bone: maximum force	0.7	1.2	1.9	-1.4	-1.3	0.9	0.9	0.9
Bone: maximum moment	0.7	1.3	2.0	-1.4	-1.4	0.9	0.9	0.9
Mean time between licks in bursts	0.7	1.0	1.5	1.2	1.1	-0.9	-0.8	-0.8
Mean num. licks in bursts	1.0	1.2	1.6	0.9	0.9	-1.0	-1.3	-1.3
Cd content in liver	0.1	0.1	0.2	0.4	0.3	-0.1	-0.1	-0.1
Co content in liver	0.2	0.2	0.3	-0.4	-0.5	0.4	0.5	0.5
Cu content in liver	3.2	3.9	4.5	-1.8	-2.0	1.9	2.1	2.1
Fe content in liver	0.0	0.0	0.1	0.2	0.2	0.3	0.0	0.0
K content in liver	0.1	0.1	0.3	0.2	0.2	-0.6	-0.3	-0.3
Mg content in liver	0.1	0.1	0.2	0.3	0.3	-0.4	-0.1	-0.1
Mn content in liver	0.0	0.0	0.1	0.1	0.1	-0.2	-0.2	-0.2
Na content in liver	0.1	0.1	0.2	-0.3	-0.3	0.4	0.4	0.4
Rb content in liver	0.5	0.6	1.0	-0.3	-0.6	0.7	1.0	1.0
Se content in liver	0.5	0.6	0.8	0.8	0.9	-0.7	-0.7	-0.7
Sr content in liver	1.7	1.6	2.3	1.1	1.1	-1.5	-1.2	-1.2
Zn content in liver	1.2	1.3	1.8	1.4	1.3	-1.3	-0.9	-0.9
Bone: minimum diameter	1.0	1.8	2.4	-1.6	-1.5	1.2	1.2	1.2
Time in familiar zone, hab. session 1	1.2	1.2	1.4	0.9	0.9	-1.2	-1.2	-1.2
Time in novel zone, hab. session 1	3.1	3.0	3.4	-1.6	-1.6	1.8	1.8	1.8
Total zone transitions, hab. session 1	0.3	0.4	0.6	-0.4	-0.4	0.7	0.7	0.8
Total locomotion distance, hab. session 1	0.6	0.9	1.1	1.0	1.1	-1.0	-0.8	-0.7
Locomotion velocity, hab. session 1	0.8	1.1	1.3	1.1	1.1	-1.1	-1.0	-0.9
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.0	0.0	-0.4	-0.4	-0.3
Time in novel zone, hab. session 2	0.6	0.6	0.9	-0.6	-0.6	0.9	0.8	0.8
Total zone transitions, hab. session 2	0.4	0.5	0.7	0.8	0.8	-0.5	-0.6	-0.5
Total locomotion distance, hab. session 2	1.1	1.4	1.6	1.2	1.3	-1.1	-1.3	-1.2
Locomotion velocity, hab. session 2	1.5	2.1	2.2	1.4	1.5	-1.4	-1.5	-1.5
Novel to familiar place preference ratio	0.5	0.5	0.7	-0.8	-0.8	0.7	0.6	0.6
Novelty place preference	0.3	0.3	0.5	-0.7	-0.7	0.5	0.5	0.5
Time in novel zone, NPP test	0.5	0.5	0.7	-0.8	-0.8	0.7	0.6	0.6
Total zone transitions, NPP test	1.0	1.4	2.2	1.5	1.5	-0.9	-1.0	-1.0
Total locomotion distance, NPP test	3.5	4.8	5.7	2.3	2.4	-2.0	-2.1	-2.1
Locomotion velocity, NPP test	4.0	5.7	6.6	2.4	2.6	-2.2	-2.4	-2.4
Intraocular pressure	0.1	0.1	0.2	0.5	0.2	0.3	0.4	0.4
Delta distance traveled before/after self-admin	1.9	2.1	2.3	1.5	1.4	-1.5	-1.4	-1.4
Delta ambulatory time before/after self-admin	1.4	1.5	1.9	1.4	1.3	-1.2	-1.1	-1.1
Parametrial fat weight	3.3	6.5	7.8	2.8	2.7	-2.5	-2.4	-2.4
Pavlov. Cond. lever latency	2.4	3.0	3.5	1.6	1.7	-1.7	-1.9	-1.9
Pavlov. Cond. magazine entry latency	4.0	5.1	5.2	-2.3	-2.3	2.3	2.3	2.2
Pavlov. Cond. change in total contacts	4.4	4.7	4.8	-2.2	-2.2	2.1	2.2	2.1
Pavlov. Cond. index score	5.3	6.7	6.8	-2.6	-2.6	2.5	2.6	2.6
Pavlov. Cond. latency score	5.2	6.6	6.9	-2.5	-2.6	2.5	2.6	2.6
Pavlov. Cond. lever contacts	2.3	2.8	3.1	-1.6	-1.6	1.6	1.8	1.7
Pavlov. Cond. magazine entry number	2.0	2.5	2.6	1.6	1.6	-1.6	-1.6	-1.6
Pavlov. Cond. intertrial magazine entries	2.1	2.6	3.2	1.8	1.7	-1.6	-1.5	-1.5
Pavlov. Cond. lever-magazine prob. diff.	5.3	6.5	6.7	-2.6	-2.6	2.5	2.6	2.6
Pavlov. Cond. response bias	2.1	2.5	2.6	-1.6	-1.6	1.5	1.6	1.6
Pavlov. Cond. lever latency	0.7	1.0	1.5	-1.2	-1.2	0.9	0.8	0.8
Pavlov. Cond. magazine entry latency	3.6	4.2	4.6	2.0	2.1	-1.9	-2.1	-2.1
Pavlov. Cond. change in total contacts	1.0	1.4	1.7	-1.1	-1.1	1.3	1.2	1.2
Pavlov. Cond. index score	1.8	2.3	2.7	1.6	1.7	-1.3	-1.4	-1.4
Pavlov. Cond. latency score	1.6	1.9	2.4	1.5	1.5	-1.2	-1.3	-1.3
Pavlov. Cond. lever contacts	1.7	2.3	3.1	1.8	1.7	-1.5	-1.3	-1.3
Pavlov. Cond. magazine entry number	0.9	1.1	1.2	-1.1	-1.1	0.8	1.1	1.1
Pavlov. Cond. intertrial magazine entries	0.6	0.7	0.9	0.9	0.8	-0.9	-0.8	-0.8
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	1.8	1.3	1.4	-1.1	-1.2	-1.2
Pavlov. Cond. response bias	1.6	2.2	2.8	1.7	1.6	-1.4	-1.3	-1.4
Time in closed arm before self-admin	0.1	0.1	0.2	-0.5	-0.4	0.2	0.2	0.2
Time in closed arm after self-admin	3.4	3.4	4.1	-1.7	-1.8	1.8	1.9	2.0
Time in open arm before self-admin	3.7	4.0	4.7	-1.8	-1.9	2.0	2.2	2.1
Time in open arm after self-admin	1.4	1.5	1.9	1.0	1.1	-1.3	-1.3	-1.4
Bone: periosteal estimation	1.0	2.0	2.6	-1.6	-1.6	1.3	1.2	1.3
Bone: periosteal perimeter	1.9	3.1	4.1	-2.0	-2.0	1.7	1.6	1.6
Bone: post-yield work	0.8	1.1	1.3	-1.2	-1.1	0.9	1.0	1.0
Progressive ratio test 1 active lever presses	0.2	0.2	0.4	0.5	0.4	-0.4	0.6	0.4
Progressive ratio test 1 breakpoint	0.2	0.2	0.5	0.4	0.3	-0.3	0.7	0.5
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.6	-0.1	-0.1	0.4	0.7	0.7
Progressive ratio test 2 active lever presses	0.7	0.7	1.5	-0.4	-0.5	0.5	1.2	1.1
Progressive ratio test 2 breakpoint	0.6	0.7	1.5	-0.5	-0.6	0.5	1.2	1.1
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.3	0.0	-0.0	-0.0	0.5	0.5
Incentive Sensitization - Responses	0.4	0.4	0.6	-0.7	-0.8	0.2	0.7	0.7
Incentive Sensitization - Breakpoint	0.7	0.7	1.0	-1.0	-1.0	0.4	0.9	0.9
Sum of active levers in priming session hrs 5-6	1.0	0.9	1.3	-0.7	-0.7	1.1	1.1	1.0
Progressive ratio	0.0	0.0	0.1	-0.1	-0.1	0.2	0.3	0.1
Food seeking constrained by brief footshock	0.8	1.0	2.4	-0.5	-0.5	1.0	1.5	1.1
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.1	-0.1	0.3	0.4	0.4
Retroperitoneal fat weight	1.8	6.0	7.1	2.5	2.5	-2.7	-2.3	-2.3
Reaction time number correct	0.7	1.0	1.5	0.9	0.8	-1.2	-1.1	-1.0
Reaction time mean minus median	0.0	0.0	0.0	-0.0	0.0	0.2	0.1	0.0
Reaction time mean minus median AUC	0.1	0.2	0.2	-0.4	-0.3	0.4	0.5	0.4
Reaction time num false alarms	0.6	0.8	1.1	1.0	1.0	-0.8	-0.8	-0.7
Reaction time num false alarms AUC	0.3	0.4	0.6	0.8	0.8	-0.5	-0.5	-0.5
Reaction time trials correct on left	0.7	1.0	1.5	0.9	0.8	-1.2	-1.1	-1.0
Reaction time trials on left	0.8	1.2	1.7	1.0	0.8	-1.3	-1.2	-1.1
Reaction time mean	0.1	0.2	0.3	-0.4	-0.3	0.5	0.4	0.3
Reaction time mean AUC	0.1	0.2	0.2	-0.5	-0.4	0.5	0.4	0.3
Median of all reaction times	0.1	0.2	0.2	-0.5	-0.4	0.5	0.4	0.3
Reaction time omissions	1.9	2.6	3.2	1.4	1.5	-1.8	-1.6	-1.7
Reaction time false alarm rate	0.1	0.1	0.3	-0.1	-0.0	0.5	0.4	0.4
Reaction time premature initiation rate	0.5	0.7	1.1	1.0	1.0	-0.8	-0.6	-0.7
Reaction time premature initiations	1.3	1.8	2.2	1.4	1.3	-1.5	-1.2	-1.3
Std. dev. reaction times	0.0	0.0	0.1	-0.3	-0.1	0.3	0.2	0.2
Reaction time trials completed	0.8	1.2	1.7	1.0	0.8	-1.3	-1.2	-1.1
Reaction time trials AUC	0.6	0.8	1.4	0.8	0.7	-1.2	-1.0	-0.9
Run reversals in cocaine runway, females	0.0	0.0	0.1	-0.1	-0.0	-0.0	0.1	-0.3
Run reversals in cocaine runway, males	0.2	0.2	0.5	-0.7	-0.5	0.3	0.2	0.1
Latency to leave start box in cocaine runway	0.4	0.5	0.6	-0.6	-0.6	0.8	0.7	0.7
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.3	-0.3	0.4	0.5	0.4
Latency to leave start box in cocaine runway, M	1.3	1.2	1.9	-1.0	-1.0	1.4	1.0	1.2
Std. dev. time between licks in bursts	1.3	1.6	2.0	1.4	1.3	-1.2	-1.2	-1.2
Total sessions with >9 infusions	2.4	2.6	4.2	-1.3	-1.3	1.4	2.1	1.9
Short access day 1 total inactive lever presses	0.1	0.1	0.3	-0.0	-0.1	0.2	0.5	0.5
Short access day 10 total inactive lever presses	0.0	0.0	0.1	-0.0	-0.1	0.4	-0.1	0.1
Short access day 1 total infusions	0.1	0.1	0.2	-0.1	-0.1	-0.2	0.4	0.3
Short access day 10 total infusions	0.4	0.5	1.1	-0.1	-0.2	0.5	1.0	1.0
Short access total infusions	0.3	0.4	0.9	-0.2	-0.3	0.3	0.9	0.8
Short access day 1 locomotion	0.3	0.3	0.7	0.3	0.4	-0.9	-0.3	-0.6
Short access day 10 total locomotion	0.0	0.0	0.0	0.2	0.2	-0.2	-0.1	-0.2
Short access total locomotion	0.0	0.0	0.1	0.0	0.1	-0.1	0.2	0.0
One hour access (0.3 mA shock)	4.5	5.2	6.1	-2.2	-2.2	2.2	2.5	2.4
Compulsive drug intake	3.6	3.7	5.0	-1.7	-1.7	2.2	1.9	1.9
One hour access (shock baseline)	1.6	1.9	2.1	-1.4	-1.4	1.2	1.4	1.5
Social response proportion	1.6	1.7	1.9	1.3	1.4	-1.3	-1.3	-1.3
Social responses	0.9	1.2	1.3	1.0	1.1	-1.1	-1.1	-1.0
Social time	2.2	2.9	3.5	1.4	1.6	-1.9	-1.9	-1.8
Soleus weight	0.0	0.1	0.1	-0.3	-0.3	-0.2	-0.0	-0.1
Bone: stiffness	2.5	3.9	5.2	-2.3	-2.2	1.8	1.7	1.7
Tibialis anterior weight	8.6	29.4	34.7	-5.9	-5.8	5.2	5.1	5.0
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	-0.5	-0.4	0.6	0.3	0.3
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.5	-0.2	-0.1	-0.7	-0.5	-0.4
Time to tail flick, test, before self-admin	0.1	0.1	0.3	0.0	0.2	-0.5	-0.4	-0.3
Time to tail flick, test, after self-admin	0.2	0.2	0.4	-0.7	-0.6	0.6	0.2	0.3
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.7	0.3	0.2	-0.8	-0.5	-0.4
Delta time to tail flick, test, before/after SA	0.6	0.6	1.1	-0.7	-0.7	1.0	0.5	0.7
Tibia length	0.1	0.2	0.4	-0.5	-0.5	0.7	0.3	0.4
Ambulatory time before self-admin	0.2	0.2	0.4	-0.2	-0.3	0.4	0.6	0.5
Ambulatory time after self-admin	0.1	0.1	0.3	0.5	0.4	-0.1	0.1	0.0
Bone: tissue strength	1.8	1.7	1.9	-1.4	-1.4	1.2	1.3	1.3
Total heroin consumption	0.3	0.3	0.5	-0.5	-0.6	0.7	0.6	0.6
Bone: trabecular number	0.2	0.3	0.4	0.4	0.4	-0.4	-0.6	-0.7
Bone: trabecular spacing	1.3	1.7	2.3	-1.0	-1.1	1.4	1.5	1.5
Bone: trabecular thickness	0.1	0.1	0.2	0.1	0.2	-0.3	-0.3	-0.4
Bone: trabecular tissue density	1.5	2.1	2.5	-1.4	-1.3	1.6	1.5	1.5
Water consumed over 24 hours	0.3	0.4	0.5	0.7	0.6	-0.7	-0.6	-0.6
Number of responses in last shaping day	2.8	2.9	4.5	1.4	1.5	-2.1	-1.6	-1.8