Dpf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Dpf2	0.06	0.03	3.6e-06	0.04	0.04	0.04	0.04	1.6e-05	3.4e-05	7.5e-05	2.4e-05
2	Liver	gene expression	Dpf2	0.09	0.04	1.2e-08	0.07	0.06	0.05	0.05	5.8e-08	2.8e-07	1.8e-06	1.7e-06
3	PL	isoform ratio	XM_006230850.4	0.03	0.02	2.8e-03	0.02	0.02	0.02	0.02	1.9e-03	2.4e-03	7.0e-03	4.7e-03
4	Adipose	mRNA stability	Dpf2	0.11	0.05	5.9e-11	0.08	0.07	0.08	0.08	6.8e-09	4.9e-08	6.5e-09	4.4e-09
5	PL	isoform ratio	NM_001108516.1	0.04	0.03	4.7e-05	0.04	0.04	0.04	0.03	1.0e-04	8.2e-05	9.0e-05	1.2e-04
6	PL	intron excision ratio	chr1_212618687_212620168	0.03	0.02	1.8e-03	0.02	0.02	0.02	0.02	1.9e-03	2.3e-03	3.2e-03	2.9e-03
7	Brain	mRNA stability	Dpf2	0.09	0.05	3.9e-06	0.06	0.04	0.05	0.05	6.7e-06	9.7e-05	8.8e-06	2.7e-05
8	PL	mRNA stability	Dpf2	0.03	0.02	6.2e-03	0.02	0.01	0.01	0.01	2.2e-03	1.4e-02	1.3e-02	1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.9	1.5	4.1	-0.9	-0.8	-0.9	1.1	0.7	0.7	1.9	2.0
Area under the delay curve	0.2	0.3	0.7	0.2	0.3	-0.2	0.5	0.6	0.2	0.8	0.8
BMI with tail	2.4	8.3	22.4	-2.5	-2.5	-1.9	2.0	1.3	1.7	4.7	4.4
BMI without tail	0.8	2.4	7.5	-1.4	-1.5	-0.4	0.8	0.5	0.6	2.7	2.4
Body weight	1.3	5.8	14.3	-3.7	-3.8	0.4	-0.6	-1.2	-0.4	2.9	2.8
Weight adjusted by age	0.8	1.2	2.1	-1.4	-1.4	0.9	-1.4	-1.3	-1.1	0.1	0.2
Bone surface	2.5	4.5	10.2	-3.2	-3.1	0.0	-0.1	-0.9	-0.7	2.6	2.9
Bone volume	1.4	2.5	6.7	-1.8	-1.7	-0.8	0.8	0.1	0.0	2.5	2.6
Breakpoint value in progressive ratio session	2.0	2.4	4.7	-2.2	-2.2	1.2	-1.0	-1.2	-1.5	1.4	1.4
Number of licking bursts	0.2	0.2	0.5	-0.6	-0.7	0.2	-0.3	-0.4	-0.4	0.6	0.5
Context. condit. distance diff. score	1.1	1.4	2.7	1.6	1.7	-0.8	1.1	1.3	1.2	-0.5	-0.4
Locomotion velocity, session 1	0.2	0.3	0.6	0.0	0.1	0.6	-0.7	-0.5	-0.1	-0.8	-0.7
Locomotion distance, session 1	0.5	0.6	1.6	-0.7	-0.7	-0.4	0.3	0.3	0.8	1.3	1.3
Locomotion velocity, session 2	1.3	1.5	3.3	-1.8	-1.8	0.3	-0.3	-0.7	-0.3	1.6	1.5
Locomotion distance, session 2	0.4	0.6	1.5	-0.9	-0.9	-0.3	-0.0	-0.0	0.6	1.2	1.1
Locomotion velocity, session 3	0.9	1.1	2.4	0.4	0.5	-1.3	1.2	1.2	1.6	0.7	0.8
Locomotion distance, session 3	0.0	0.0	0.0	0.1	0.2	-0.1	0.0	0.2	0.2	-0.0	-0.1
Stereotopy head waving bouts, day 3	1.6	1.8	5.6	0.8	0.8	-1.9	1.4	1.4	2.4	0.4	0.4
Stereotopy head waving duration, day 3	1.0	1.3	2.6	1.0	1.0	-1.5	1.3	1.3	1.6	0.3	0.3
Locomotion velocity, session 7	2.5	2.7	5.0	0.7	0.6	-2.2	1.9	1.7	2.2	1.5	1.5
Locomotion distance, session 7	0.5	0.6	2.2	0.0	-0.0	-1.1	0.6	0.7	1.5	0.5	0.6
Stereotopy head waving bouts, day 7	0.6	0.7	1.5	0.1	0.2	-1.0	1.0	0.8	0.5	1.2	1.1
Stereotopy head waving duration, day 7	0.7	0.9	3.0	-0.8	-0.8	-0.2	0.4	0.1	-0.3	1.7	1.6
Locomotion velocity, session 8	0.8	1.0	1.7	-1.2	-1.2	0.8	-1.3	-1.3	-0.4	-0.7	-0.7
Locomotion distance, session 8	0.8	1.2	2.8	0.6	0.6	-1.4	1.3	1.2	1.7	0.7	0.7
Degree of sensitization distance	0.7	0.7	2.2	-0.0	-0.2	-1.3	0.8	0.7	1.5	0.7	0.7
Degree of sensitization stereotypy	0.6	0.6	2.2	-0.7	-0.6	-0.2	0.4	0.1	-0.4	1.5	1.4
Conditioned locomotion	0.8	1.0	2.0	-1.4	-1.4	0.8	-1.1	-1.1	-0.7	0.4	0.3
Cocaine response after cond. corrected	1.0	1.2	2.1	1.4	1.5	-0.8	0.6	0.9	1.4	-0.9	-0.9
Cocaine response after cond. not corrected	0.8	0.9	1.6	1.2	1.2	-0.9	0.6	0.8	1.3	-0.8	-0.8
Cocaine response before conditioning	0.5	0.6	1.2	-1.1	-1.1	0.4	-0.3	-0.6	-0.9	0.7	0.7
Saline control response	2.1	2.8	6.4	-2.5	-2.5	1.2	-1.7	-1.9	-1.0	0.3	0.4
Bone: connectivity density	1.5	2.3	5.3	-2.2	-2.0	-0.1	0.2	-0.3	-0.1	2.0	2.3
Bone: cortical apparent density	0.4	0.6	1.4	-0.4	-0.4	1.2	-1.0	-0.7	-1.2	-0.3	-0.2
Bone: cortical area	0.3	0.5	1.4	-1.2	-1.1	0.1	-0.2	-0.7	-0.5	0.5	0.5
Bone: cortical porosity	0.2	0.2	0.5	-0.3	-0.4	0.2	0.2	0.0	-0.3	0.6	0.7
Bone: cortical porosity	0.3	0.3	0.7	-0.7	-0.8	0.3	-0.0	-0.3	-0.4	0.7	0.8
Bone: cortical thickness	2.7	4.5	7.0	-2.3	-2.3	2.5	-2.5	-2.6	-2.3	-0.6	-0.6
Bone: cortical thickness	1.3	1.5	2.7	-0.7	-0.8	1.6	-1.6	-1.4	-1.2	-1.1	-1.0
Bone: cortical tissue density	0.6	0.9	1.9	-0.6	-0.6	1.4	-1.2	-0.9	-1.3	-0.3	-0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	-0.3	-0.4	-0.2	0.1	0.0	0.2	0.7	0.6
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.0	-0.1	0.1	-0.2	-0.1	-0.2	0.2	0.1
Condit. Reinf. active responses	0.4	0.5	0.9	-0.1	-0.1	-0.8	0.7	0.6	0.7	1.0	0.9
Condit. Reinf. inactive responses	0.9	1.1	1.9	0.2	0.3	-1.4	1.4	1.1	1.3	0.9	1.0
Incentive salience index mean	0.4	0.5	1.5	-0.5	-0.6	-0.4	0.5	0.3	0.4	1.2	1.2
Condit. Reinf. lever presses	0.5	0.7	1.8	-0.8	-0.9	-0.5	0.7	0.3	0.2	1.4	1.3
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	0.2	0.2	-0.6	0.8	0.5	-0.0	0.6	0.5
Condit. Reinf. active-inactive response ratio	1.3	1.5	3.4	0.8	0.8	-1.8	1.8	1.3	1.1	0.7	0.7
Condit. Reinf. active responses	0.2	0.3	1.0	-0.4	-0.4	0.1	0.2	0.1	-0.5	1.0	0.9
Condit. Reinf. inactive responses	0.5	0.7	1.3	-0.9	-0.9	1.1	-0.8	-0.5	-0.9	0.6	0.5
Condit. Reinf. lever presses	1.2	1.7	3.3	-1.8	-1.8	0.3	-0.3	-0.8	-1.2	1.6	1.5
Condit. Reinf. lever reinforcers received	0.4	0.5	1.1	-0.8	-0.8	0.3	-0.1	-0.2	-0.9	1.0	0.9
Conditioned reinforcement - actives	0.0	0.1	0.4	0.1	-0.0	-0.6	-0.1	-0.2	-0.2	-0.1	-0.3
Conditioned reinforcement - inactives	1.2	1.8	4.1	1.9	2.0	-1.3	1.1	1.4	0.6	-0.8	-0.8
Conditioned locomotion	3.9	5.1	11.2	3.3	3.3	-1.9	1.4	2.0	1.5	-1.7	-1.9
Patch foraging indifference point 0 sec	0.0	0.1	0.2	-0.1	0.0	-0.5	0.3	0.3	0.5	0.2	0.2
Patch foraging indifference point AUC	1.7	2.4	4.2	-1.9	-2.0	1.5	-1.5	-1.6	-1.9	0.8	0.7
Delay disc. indifference point, 0s delay	0.8	0.9	1.3	1.0	0.9	-0.8	1.1	1.1	0.9	0.9	0.7
Delay disc. indifference point, 16s delay	0.6	0.6	1.3	0.7	0.8	-0.8	0.9	1.1	0.6	0.8	0.5
Delay disc. indifference point, 2s delay	0.4	0.4	0.7	0.5	0.4	-0.8	0.8	0.8	0.7	0.4	0.5
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	0.2	0.3	0.6	-0.7	-0.3	-0.3	-0.6	-0.7
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.4	0.4	-0.3	0.3	0.6	0.7	0.2	0.4
Delay disc. indifference point, 8s delay	0.0	0.1	0.1	0.2	0.3	0.3	0.1	0.3	-0.1	0.2	0.4
Indifference point function ln k	4.3	7.5	13.9	3.6	3.7	-2.2	2.2	2.5	3.0	-2.0	-1.8
Indifference point function log k	4.3	7.5	13.9	3.6	3.7	-2.2	2.2	2.5	3.0	-2.0	-1.8
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	-0.2	-0.1	-0.0	-0.2	-0.2	0.2	-0.4	-0.4
Patch foraging total patch changes 12 sec	2.9	3.8	8.0	-2.7	-2.8	1.6	-1.7	-1.6	-1.7	1.6	1.4
Patch foraging total patch changes 18 sec	0.3	0.5	1.1	-1.0	-1.1	0.1	-0.2	-0.2	-0.2	0.9	1.0
Patch foraging total patch changes 24 sec	1.2	2.1	3.5	-1.8	-1.9	1.3	-1.7	-1.8	-1.3	-0.0	-0.1
Patch foraging total patch changes 6 sec	0.5	0.8	2.4	-1.5	-1.5	0.4	-0.6	-0.8	-0.2	0.5	0.5
Patch foraging time to switch 0 sec	1.4	3.0	8.9	-1.7	-1.6	-0.7	0.8	0.5	0.2	3.0	2.9
Patch foraging water rate 0 sec	2.1	4.3	10.6	2.7	2.5	-0.2	0.3	0.4	0.6	-3.3	-3.2
Patch foraging water rate 12 sec	4.3	8.9	19.2	3.9	4.0	-0.3	0.5	0.9	1.2	-4.4	-4.2
Patch foraging water rate 18 sec	1.9	2.9	5.7	2.2	2.3	-0.6	0.6	0.8	1.3	-2.4	-2.2
Patch foraging water rate 24 sec	2.9	4.1	7.9	2.7	2.7	-0.5	0.7	0.8	1.2	-2.8	-2.8
Patch foraging water rate 6 sec	3.3	4.9	12.1	2.7	2.6	-0.2	0.2	0.5	1.0	-3.5	-3.3
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.7	0.2	0.2	-0.6	0.4	0.8	0.7	0.8	0.8
Distance traveled before self-admin	0.6	0.8	2.2	-0.9	-0.9	-0.1	0.5	0.0	-0.3	1.5	1.5
Distance traveled after self-admin	0.4	0.4	1.3	-0.6	-0.7	0.9	-0.1	-0.5	-1.2	0.4	0.4
Extensor digitorum longus weight	3.8	15.0	33.9	-5.8	-5.8	2.7	-3.0	-3.6	-2.8	2.9	2.7
Bone: elastic displacement	1.6	1.8	5.6	1.1	1.0	0.7	-0.8	-0.5	-0.2	-2.3	-2.4
Bone: elastic work	1.2	1.6	2.6	-1.1	-1.1	1.6	-1.6	-1.5	-1.1	-0.9	-1.0
Bone: endosteal estimation	2.1	4.5	8.5	1.1	1.2	-2.9	2.9	2.5	2.6	1.4	1.3
Bone: endosteal perimeter	2.6	5.6	10.9	1.3	1.4	-3.2	3.3	2.7	2.7	1.6	1.6
Epididymis fat weight	2.3	8.0	12.7	3.6	3.6	-3.2	3.4	2.9	2.7	-0.8	-0.9
Delta time in closed arm before/after self-admin	0.4	0.3	0.7	-0.3	-0.3	0.8	-0.9	-0.6	-0.1	-0.6	-0.6
Delta time in open arm before/after self-admin	0.3	0.3	0.7	-0.5	-0.5	0.4	0.2	-0.3	-0.9	0.5	0.5
Diff in mean of infusions in LGA sessions	0.4	0.5	0.8	-0.9	-0.9	0.7	-0.8	-0.9	-0.7	-0.1	-0.1
Delay discount exponential model param	0.1	0.1	0.5	-0.1	-0.2	-0.0	-0.2	-0.4	-0.1	-0.6	-0.7
Extinction: sum of active levers before priming	1.6	1.8	3.5	-1.8	-1.9	-0.0	-0.5	-0.5	-0.2	1.8	1.9
Active lever presses in extinction session 6	1.5	1.5	3.5	-1.8	-1.9	0.5	-0.8	-1.3	-1.0	0.9	1.0
Bone: final force	1.2	1.9	5.2	-2.3	-2.2	0.4	-0.6	-1.1	-0.7	1.2	1.2
Bone: final moment	1.1	1.7	4.7	-2.2	-2.1	0.5	-0.6	-1.0	-0.7	1.1	1.2
Food consumed during 24 hour testing period	0.2	0.3	0.6	-0.1	-0.1	0.4	-0.7	-0.8	-0.8	-0.5	-0.6
Glucose	3.0	4.7	7.4	2.2	2.1	-2.5	2.7	2.7	2.6	0.6	0.7
Heart weight	2.2	3.4	7.2	1.5	1.4	-2.1	2.3	2.3	2.7	1.0	0.9
Delay discount hyperbolic model param	0.2	0.2	0.6	-0.2	-0.2	0.1	-0.4	-0.5	-0.2	-0.7	-0.8
Intermittent access intake day 1-15 change	0.4	0.8	1.6	1.3	1.2	-1.0	0.5	0.7	0.6	-0.8	-0.9
Intermittent access intake escalation	0.3	0.6	1.2	1.1	1.0	-0.9	0.4	0.5	0.4	-0.8	-0.9
Intermittent access intake escalation 2	0.4	0.5	1.1	1.0	1.0	-0.7	0.4	0.5	0.2	-0.7	-0.8
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.3	0.4	0.4	0.3	-0.6	0.1	-0.3	-0.2	-0.1
Intermitt. access day 15 inactive lever presses	0.8	1.5	2.7	1.6	1.6	-1.4	1.3	1.6	1.0	-0.0	0.1
Intermitt. access escalation Index	1.9	2.7	5.0	2.2	2.1	-1.3	2.0	1.8	1.6	-0.5	-0.4
Intermittent access day 1 total infusions	3.8	6.1	10.5	2.0	2.0	-3.2	3.2	3.0	2.9	1.2	1.1
Intermittent access day 15 total infusions	3.9	5.7	10.0	2.9	2.7	-3.2	2.6	2.7	2.4	-0.4	-0.5
Intermittent access terminal intake (last 3 days)	4.7	6.2	12.1	2.6	2.5	-3.5	3.0	2.8	2.7	0.1	-0.0
Intermittent access total infusions	4.9	5.8	11.4	2.3	2.2	-3.4	2.9	2.8	2.8	0.5	0.4
Intermittent access day 1 locomotion	2.9	3.6	6.2	1.8	1.7	-2.5	2.2	2.4	2.2	0.7	0.7
Intermittent access day 15 total locomotion	2.6	4.7	8.2	2.4	2.5	-2.9	2.5	2.6	2.1	0.1	0.0
Intermittent access total locomotion	7.4	8.8	16.0	3.0	3.0	-4.0	3.7	3.6	3.1	0.7	0.6
Intermittent access standard deviation	0.5	0.9	2.3	1.5	1.5	-0.6	0.3	0.8	0.3	-1.0	-1.0
Left kidney weight	0.7	3.4	6.8	2.0	1.9	-2.2	2.6	2.1	1.9	0.5	0.3
Right kidney weight	0.2	1.0	1.9	1.4	1.3	-1.0	1.2	0.9	0.7	-0.5	-0.6
Cocaine induced anxiety	0.0	0.1	0.1	-0.2	-0.2	-0.1	-0.1	-0.0	-0.3	0.3	0.3
Post-drug Anxiety	0.4	0.4	1.0	-1.0	-1.0	0.2	-0.6	-0.6	-0.5	0.5	0.5
Baseline Anxiety	0.4	0.5	1.2	-0.7	-0.7	0.8	-1.1	-0.9	-0.3	-0.4	-0.4
Tail length	0.7	2.9	5.3	-1.0	-1.3	2.2	-2.3	-2.1	-1.9	-1.0	-1.1
Length with tail	1.4	6.0	9.2	-2.9	-3.0	2.6	-2.9	-3.0	-2.3	-0.2	-0.2
Length without tail	1.5	4.8	7.9	-2.8	-2.6	2.4	-2.6	-2.8	-1.9	-0.6	-0.5
Times rat made contact with spout	0.4	0.5	1.3	-0.6	-0.6	1.1	-0.8	-0.6	-0.9	0.5	0.3
Lifetime Intake	3.6	4.4	8.3	2.0	1.9	-2.9	2.5	2.5	2.5	0.4	0.3
Liver weight, left	0.7	1.1	1.6	1.3	1.3	-0.9	0.7	0.7	1.1	-1.1	-1.2
Liver weight, right	1.5	2.7	4.4	2.1	2.1	-1.2	0.7	1.3	1.9	-1.7	-1.7
Locomotor activity	1.6	2.5	6.3	1.9	1.9	0.1	-0.3	0.3	0.5	-2.4	-2.5
Locomotor testing distance	1.9	3.4	8.6	2.2	2.3	0.3	-0.3	0.3	0.5	-2.8	-2.9
Locomotor testing rearing	1.3	2.7	5.8	2.2	2.3	0.4	-0.0	0.5	0.4	-2.4	-2.3
Locomotion in novel chamber	3.6	4.6	7.3	2.7	2.7	-2.5	2.2	2.1	2.2	-1.0	-1.0
Locomotion in novel chamber post-restriction	1.6	2.6	4.7	2.2	2.2	-1.7	1.8	1.8	1.3	-0.4	-0.5
Fecal boli incidents, locomotor time 1	0.1	0.2	0.5	0.0	-0.0	-0.5	0.5	0.2	-0.4	0.7	0.7
Change in fecal boli incidents, locomotor task	0.1	0.1	0.9	-0.1	-0.0	-0.2	-0.0	0.2	1.0	-0.1	-0.2
Time >=10cm from walls, locomotor time 1	3.2	3.4	6.8	0.8	0.8	-2.6	2.6	2.1	1.7	1.6	1.6
Bouts of movement, locomotor time 1	2.6	2.9	7.3	-1.4	-1.5	2.4	-1.7	-1.6	-2.7	0.4	0.3
Total resting periods, locomotor time 1	1.7	1.8	5.0	-1.2	-1.2	1.8	-1.3	-1.2	-2.2	0.6	0.5
Rest time, locomotor task time 1	0.7	0.9	2.2	1.5	1.5	-0.5	0.8	0.7	0.2	-0.9	-0.9
Distance moved, locomotor task time 1	0.4	0.6	1.2	-0.3	-0.3	-0.8	0.6	0.5	0.9	1.0	1.1
Vertical activity count, locomotor time 1	0.3	0.8	1.6	1.0	1.1	-1.0	0.7	0.8	1.2	-0.5	-0.5
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.6	-0.1	-0.1	-0.2	0.4	0.1	-0.5	0.7	0.8
Bouts of movement, locomotor time 2	0.7	1.1	2.6	-1.0	-1.0	1.6	-0.9	-0.6	-1.5	0.7	0.7
Total resting periods, locomotor time 2	0.4	0.7	1.7	-0.7	-0.7	1.3	-0.4	-0.3	-1.2	0.8	0.8
Rest time, locomotor task time 2	1.3	1.7	3.5	1.8	1.9	-0.8	1.7	1.5	0.7	-0.4	-0.4
Distance moved, locomotor task time 2	0.8	0.9	1.7	-1.1	-1.2	0.8	-1.3	-1.3	-0.8	0.0	0.1
Vertical activity count, locomotor time 2	0.8	1.1	3.0	0.1	-0.0	0.6	-1.3	-1.1	-0.1	-1.7	-1.7
Light reinforcement 1	0.1	0.2	0.5	0.3	0.3	0.4	-0.4	-0.2	-0.3	-0.7	-0.7
Light reinforcement 2	0.5	0.8	1.9	1.0	1.0	-1.4	1.0	0.8	0.8	-0.2	-0.1
Bone: marrow area	2.2	4.8	9.0	1.2	1.3	-3.0	3.0	2.6	2.8	1.4	1.3
Bone: maximum diameter	0.2	0.3	0.8	-0.6	-0.5	-0.9	0.6	-0.0	0.3	0.6	0.5
Bone: maximum force	1.8	3.3	7.1	-2.7	-2.6	-0.3	0.2	-0.5	-0.2	2.4	2.5
Bone: maximum moment	1.7	2.9	6.4	-2.5	-2.4	-0.2	0.1	-0.5	-0.2	2.3	2.4
Mean time between licks in bursts	0.3	0.7	1.5	-0.6	-0.6	1.0	-1.2	-0.9	-0.3	-0.9	-0.9
Mean num. licks in bursts	0.1	0.2	0.4	0.5	0.7	0.3	-0.1	0.2	0.1	-0.4	-0.4
Cd content in liver	0.7	0.8	1.5	1.1	1.2	-0.9	1.2	1.0	0.4	0.1	0.1
Co content in liver	1.7	2.0	4.9	1.3	1.2	1.1	-0.9	-0.5	-0.7	-2.2	-2.2
Cu content in liver	0.2	0.2	0.8	0.1	0.1	-0.1	0.3	0.5	-0.0	0.9	0.8
Fe content in liver	0.2	0.2	0.4	-0.4	-0.4	-0.1	-0.6	-0.6	0.2	-0.5	-0.6
K content in liver	0.4	0.4	0.8	-0.7	-0.7	-0.3	0.4	0.1	0.6	0.9	0.9
Mg content in liver	0.5	0.5	1.1	0.6	0.6	-0.7	1.0	0.8	1.0	0.2	0.1
Mn content in liver	1.6	1.7	4.6	-2.1	-2.1	0.3	-0.8	-1.3	-0.7	1.0	0.9
Na content in liver	0.5	0.6	1.0	-0.7	-0.7	0.8	-0.8	-1.0	-0.8	-0.5	-0.5
Rb content in liver	1.2	1.4	2.7	1.6	1.7	-0.8	1.1	1.2	1.2	-0.5	-0.7
Se content in liver	0.2	0.2	0.7	0.4	0.4	-0.8	0.7	0.5	0.4	0.2	0.2
Sr content in liver	2.5	2.2	3.6	-1.6	-1.7	1.7	-1.5	-1.8	-1.9	-0.1	-0.0
Zn content in liver	0.2	0.2	0.3	-0.5	-0.6	0.5	-0.3	-0.3	-0.6	0.5	0.5
Bone: minimum diameter	2.4	4.3	8.6	1.1	1.2	-2.4	2.9	2.5	2.2	1.8	1.8
Time in familiar zone, hab. session 1	0.6	0.6	1.1	0.6	0.5	-1.0	1.0	0.9	1.0	0.5	0.5
Time in novel zone, hab. session 1	0.8	0.8	2.3	0.3	0.4	0.9	-0.7	-0.6	-0.4	-1.5	-1.5
Total zone transitions, hab. session 1	0.4	0.6	1.4	-0.9	-0.9	0.3	-0.4	-0.4	-0.5	1.2	1.0
Total locomotion distance, hab. session 1	0.7	1.1	1.8	0.7	0.6	-1.3	1.2	1.2	1.3	0.8	0.7
Locomotion velocity, hab. session 1	0.3	0.5	0.8	0.2	0.1	-0.8	0.7	0.7	0.8	0.9	0.8
Time in familiar zone, hab. session 2	0.5	0.6	1.6	0.0	-0.0	0.5	-0.8	-0.5	0.2	-1.3	-1.3
Time in novel zone, hab. session 2	0.4	0.4	1.3	-0.2	-0.2	-0.2	0.5	0.3	-0.2	1.2	1.1
Total zone transitions, hab. session 2	1.4	1.8	5.1	-1.3	-1.3	-0.4	0.5	0.3	0.6	2.3	2.3
Total locomotion distance, hab. session 2	1.1	1.4	2.3	0.2	0.1	-1.2	1.3	1.2	1.5	1.5	1.5
Locomotion velocity, hab. session 2	1.4	1.9	2.7	0.4	0.3	-1.5	1.6	1.5	1.6	1.6	1.5
Novel to familiar place preference ratio	0.9	1.0	2.3	-1.2	-1.2	0.1	-0.1	-0.3	-0.8	1.5	1.5
Novelty place preference	0.6	0.6	1.7	-0.8	-0.7	0.0	0.1	-0.0	-0.6	1.3	1.3
Time in novel zone, NPP test	0.4	0.4	1.2	-0.6	-0.6	-0.0	0.1	-0.0	-0.5	1.1	1.1
Total zone transitions, NPP test	1.3	1.8	3.7	-1.9	-1.9	0.3	-0.4	-0.7	-0.4	1.8	1.8
Total locomotion distance, NPP test	0.4	0.6	1.2	-0.2	-0.3	-0.6	0.7	0.6	0.8	1.1	1.1
Locomotion velocity, NPP test	0.4	0.5	1.5	-0.3	-0.3	-0.5	0.6	0.5	0.5	1.2	1.2
Intraocular pressure	0.5	0.7	1.6	1.2	1.2	0.0	-0.1	0.2	-0.6	-1.0	-1.1
Delta distance traveled before/after self-admin	0.7	0.7	1.7	0.3	0.2	1.0	-0.7	-0.5	-0.6	-1.3	-1.3
Delta ambulatory time before/after self-admin	0.6	0.7	1.4	0.1	-0.0	1.0	-0.9	-0.7	-0.7	-1.2	-1.2
Parametrial fat weight	2.9	6.8	10.9	3.0	2.9	-3.0	3.3	3.2	2.7	0.1	0.2
Pavlov. Cond. lever latency	0.2	0.3	0.7	0.5	0.6	0.1	-0.3	-0.1	-0.0	-0.9	-0.8
Pavlov. Cond. magazine entry latency	0.7	1.0	3.1	-0.5	-0.6	-0.3	0.8	0.5	0.2	1.8	1.7
Pavlov. Cond. change in total contacts	0.7	0.7	2.4	-0.3	-0.3	-0.3	0.7	0.5	-0.3	1.5	1.5
Pavlov. Cond. index score	0.2	0.3	0.8	-0.5	-0.6	0.3	0.2	-0.0	-0.5	0.9	0.8
Pavlov. Cond. latency score	0.2	0.3	0.8	-0.3	-0.5	-0.0	0.4	0.2	-0.1	0.9	0.9
Pavlov. Cond. lever contacts	0.2	0.2	0.6	-0.2	-0.3	-0.2	0.5	0.3	0.3	0.8	0.8
Pavlov. Cond. magazine entry number	0.3	0.4	0.8	0.6	0.7	-0.6	0.2	0.4	0.9	-0.8	-0.7
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.7	0.8	0.8	0.1	0.2	0.2	-0.2	-0.6	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.5	-0.6	-0.8	0.2	0.2	0.0	-0.5	1.2	1.2
Pavlov. Cond. response bias	0.2	0.3	0.5	-0.5	-0.6	0.4	-0.0	-0.2	-0.6	0.7	0.6
Pavlov. Cond. lever latency	0.3	0.4	0.9	0.9	1.0	0.1	0.1	0.5	0.5	-0.7	-0.6
Pavlov. Cond. magazine entry latency	2.8	3.3	6.1	-2.4	-2.5	1.1	-1.0	-1.2	-1.6	2.1	2.0
Pavlov. Cond. change in total contacts	1.2	2.0	4.7	-1.6	-1.6	0.1	-0.1	-0.4	-1.1	2.2	2.1
Pavlov. Cond. index score	1.6	2.1	3.9	-1.9	-2.0	0.3	-0.3	-0.8	-1.1	2.0	1.9
Pavlov. Cond. latency score	1.3	1.8	3.6	-1.7	-1.8	0.1	-0.2	-0.6	-0.9	1.9	1.8
Pavlov. Cond. lever contacts	0.3	0.4	0.9	-0.9	-1.0	0.0	-0.1	-0.5	-0.7	0.8	0.7
Pavlov. Cond. magazine entry number	4.5	5.5	10.4	3.2	3.2	-1.5	1.5	1.8	2.2	-2.4	-2.3
Pavlov. Cond. intertrial magazine entries	0.6	0.9	1.5	1.2	1.2	-0.8	0.9	0.8	0.8	-0.7	-0.7
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.5	4.8	-2.1	-2.2	0.5	-0.5	-0.9	-1.3	2.0	2.0
Pavlov. Cond. response bias	1.3	1.7	3.3	-1.7	-1.8	0.5	-0.4	-0.8	-1.2	1.6	1.5
Time in closed arm before self-admin	0.5	0.7	1.6	0.5	0.5	-1.3	1.0	0.9	0.8	0.7	0.6
Time in closed arm after self-admin	0.2	0.3	0.8	0.4	0.3	-0.8	0.2	0.6	0.9	-0.2	-0.2
Time in open arm before self-admin	0.6	0.7	1.6	0.6	0.6	0.8	-0.8	-0.3	0.2	-1.3	-1.2
Time in open arm after self-admin	0.4	0.4	1.4	-0.1	-0.1	1.2	-0.4	-0.7	-0.9	-0.4	-0.4
Bone: periosteal estimation	0.7	1.4	3.0	-0.1	0.0	-1.7	1.7	1.1	1.3	1.2	1.2
Bone: periosteal perimeter	0.5	0.9	1.5	-0.5	-0.4	-1.2	1.2	0.6	0.8	1.2	1.2
Bone: post-yield work	6.5	9.6	22.2	-0.9	-0.8	-3.0	3.4	2.5	2.3	4.5	4.7
Progressive ratio test 1 active lever presses	0.3	0.3	0.6	0.7	0.6	-0.7	0.8	0.7	0.4	0.1	0.0
Progressive ratio test 1 breakpoint	0.2	0.3	0.5	0.6	0.6	-0.7	0.7	0.6	0.4	0.1	0.0
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.1	0.3	0.4	0.1	-0.4	0.2	-0.3	-0.0	-0.0
Progressive ratio test 2 active lever presses	2.0	2.3	4.0	1.8	1.8	-2.0	1.6	1.7	1.4	-0.2	-0.3
Progressive ratio test 2 breakpoint	1.9	2.2	3.7	1.8	1.8	-1.9	1.6	1.7	1.4	-0.3	-0.4
Progressive ratio test 2 inactive lever presses	4.2	6.7	11.7	3.4	3.4	-3.0	2.6	2.9	2.4	-0.6	-0.7
Incentive Sensitization - Responses	0.5	0.6	1.5	0.1	0.0	-1.2	1.0	0.8	1.0	0.8	0.7
Incentive Sensitization - Breakpoint	0.5	0.7	1.7	0.3	0.2	-1.3	1.0	0.9	1.0	0.7	0.6
Sum of active levers in priming session hrs 5-6	1.6	1.5	2.8	-1.2	-1.3	0.8	-1.5	-1.7	-1.6	-0.6	-0.6
Progressive ratio	1.6	2.5	7.3	-1.1	-1.0	-1.3	1.1	0.8	0.8	2.7	2.6
Food seeking constrained by brief footshock	0.1	0.1	0.4	-0.4	-0.4	-0.1	-0.6	-0.2	0.3	-0.2	-0.3
Seeking ratio, punishment vs. effort	1.6	2.3	6.9	1.3	1.3	0.8	-0.9	-0.4	0.0	-2.6	-2.5
Retroperitoneal fat weight	6.0	25.5	47.2	6.9	6.8	-4.7	4.7	5.2	5.1	-2.7	-2.6
Reaction time number correct	0.3	0.5	1.0	-0.4	-0.6	0.2	-1.0	-1.0	-0.3	-0.8	-0.8
Reaction time mean minus median	1.1	2.8	5.1	-2.3	-2.2	0.8	-0.9	-1.2	-1.5	1.9	1.9
Reaction time mean minus median AUC	0.6	1.5	2.4	-1.6	-1.5	1.0	-1.2	-1.2	-1.5	0.8	0.9
Reaction time num false alarms	0.4	0.5	1.6	0.6	0.6	0.2	-0.2	0.0	0.6	-1.3	-1.3
Reaction time num false alarms AUC	0.2	0.3	0.8	-0.1	-0.1	0.5	-0.7	-0.4	0.2	-0.9	-0.9
Reaction time trials correct on left	0.3	0.5	1.0	-0.4	-0.6	0.2	-1.0	-1.0	-0.3	-0.8	-0.8
Reaction time trials on left	0.3	0.6	1.3	-0.5	-0.7	0.3	-1.1	-1.1	-0.4	-0.8	-0.8
Reaction time mean	0.2	0.3	0.6	-0.3	-0.3	0.2	0.0	-0.0	-0.7	0.8	0.8
Reaction time mean AUC	0.2	0.3	1.0	-0.2	-0.3	0.0	0.2	0.2	-0.6	1.0	1.0
Median of all reaction times	0.1	0.2	0.3	0.3	0.2	-0.1	0.5	0.5	-0.3	0.6	0.6
Reaction time omissions	1.0	1.5	2.6	-1.6	-1.6	0.8	-1.3	-1.1	-1.1	1.0	1.1
Reaction time false alarm rate	0.2	0.2	0.4	0.4	0.5	0.1	0.1	0.3	0.6	-0.6	-0.6
Reaction time premature initiation rate	2.0	2.8	4.8	-1.8	-1.8	2.2	-2.0	-2.1	-1.5	-0.4	-0.4
Reaction time premature initiations	2.8	5.0	8.4	-2.3	-2.3	2.7	-2.9	-2.9	-2.1	-0.7	-0.8
Std. dev. reaction times	0.6	1.1	1.6	-1.3	-1.3	0.6	-0.6	-0.7	-1.2	1.1	1.2
Reaction time trials completed	0.3	0.6	1.3	-0.5	-0.7	0.3	-1.1	-1.1	-0.4	-0.8	-0.8
Reaction time trials AUC	0.2	0.5	0.9	-0.3	-0.5	0.2	-1.0	-0.9	-0.2	-0.8	-0.8
Run reversals in cocaine runway, females	0.6	0.6	1.3	-0.5	-0.4	-0.7	0.4	0.6	1.0	1.1	1.1
Run reversals in cocaine runway, males	1.1	1.1	3.3	0.5	0.5	0.7	-0.6	-0.6	-0.7	-1.8	-1.8
Latency to leave start box in cocaine runway	1.0	1.1	1.9	0.2	0.4	-1.3	1.4	1.2	1.1	1.2	1.2
Latency to leave start box in cocaine runway, F	0.4	0.4	0.9	0.2	0.4	-0.3	0.8	0.8	0.3	1.0	0.9
Latency to leave start box in cocaine runway, M	0.6	0.6	1.8	-0.2	-0.2	-1.3	0.8	0.6	1.1	0.5	0.5
Std. dev. time between licks in bursts	0.5	0.6	1.9	0.1	0.1	0.7	-0.7	-0.6	0.1	-1.4	-1.4
Total sessions with >9 infusions	0.8	0.9	1.9	0.2	0.0	-1.2	1.4	1.0	1.1	1.0	0.9
Short access day 1 total inactive lever presses	1.3	1.8	2.9	1.7	1.7	-1.4	1.0	1.6	1.5	-0.5	-0.4
Short access day 10 total inactive lever presses	0.1	0.3	0.7	0.8	0.9	-0.1	-0.6	0.5	0.5	-0.6	-0.5
Short access day 1 total infusions	2.0	2.7	4.6	1.5	1.4	-2.1	2.0	2.1	2.0	0.5	0.4
Short access day 10 total infusions	3.2	4.1	7.2	0.8	0.7	-2.7	2.6	2.3	2.4	1.8	1.8
Short access total infusions	1.9	2.5	5.0	0.9	0.8	-2.2	1.9	1.8	2.1	1.0	0.9
Short access day 1 locomotion	1.6	2.0	3.4	1.5	1.4	-1.8	1.5	1.7	1.7	0.1	0.1
Short access day 10 total locomotion	1.1	2.1	3.8	1.2	1.2	-2.0	1.6	1.8	1.6	0.8	0.9
Short access total locomotion	2.0	2.4	4.3	1.5	1.4	-2.1	1.9	1.9	1.8	0.6	0.6
One hour access (0.3 mA shock)	4.7	5.4	9.5	3.0	3.1	-2.5	2.1	2.4	2.3	-1.0	-1.1
Compulsive drug intake	2.9	3.4	8.0	-1.6	-1.5	2.8	-2.1	-2.2	-2.0	-0.9	-0.9
One hour access (shock baseline)	4.5	6.9	11.0	3.3	3.2	-3.3	2.7	3.0	2.5	-0.4	-0.5
Social response proportion	0.5	0.6	1.2	-1.1	-1.0	0.5	-0.6	-0.6	-0.8	0.6	0.6
Social responses	0.4	0.5	0.9	-0.5	-0.5	0.8	-0.9	-0.8	-0.8	-0.4	-0.5
Social time	0.5	0.6	1.6	-0.5	-0.5	0.7	-1.3	-1.1	-0.6	-0.6	-0.6
Soleus weight	2.5	7.3	15.2	3.9	3.8	-2.1	2.5	2.6	2.3	-1.5	-1.7
Bone: stiffness	1.6	2.7	5.9	-2.2	-2.2	-0.4	0.2	-0.4	-0.3	2.3	2.4
Tibialis anterior weight	5.9	19.9	39.6	-6.3	-6.3	3.8	-4.4	-5.1	-4.2	1.3	1.3
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.9	-0.3	-0.3	-0.8	0.4	0.3	0.6	0.9	1.0
Time to tail flick, vehicle, after self-admin	0.9	1.2	2.9	-0.6	-0.6	-1.0	0.8	0.7	1.1	1.7	1.7
Time to tail flick, test, before self-admin	2.7	2.8	5.4	1.5	1.5	-2.0	1.9	2.1	2.3	0.5	0.5
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.2	-0.2	-0.0	0.1	-0.2	-0.1	-0.0	0.0
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.6	-0.6	-0.5	-0.0	0.1	0.1	0.2	0.8	0.7
Delta time to tail flick, test, before/after SA	3.6	3.7	6.8	-1.4	-1.4	2.2	-2.2	-2.5	-2.6	-1.1	-1.1
Tibia length	0.6	1.7	3.5	-1.9	-1.8	0.5	-0.4	-1.3	-1.7	1.0	0.8
Ambulatory time before self-admin	0.6	0.8	2.3	-0.8	-0.8	-0.4	0.8	0.2	-0.1	1.5	1.5
Ambulatory time after self-admin	0.3	0.4	1.2	0.3	0.2	-0.3	1.1	0.7	-0.1	0.7	0.7
Bone: tissue strength	0.1	0.1	0.2	-0.1	-0.1	-0.4	0.2	0.2	0.3	0.4	0.4
Total heroin consumption	3.4	4.0	7.2	-2.7	-2.7	1.6	-1.9	-1.9	-2.0	1.3	1.4
Bone: trabecular number	1.0	1.6	4.4	-1.2	-1.1	-0.8	0.9	0.4	0.4	2.0	2.1
Bone: trabecular spacing	0.4	0.5	1.1	0.9	0.8	0.4	-0.5	0.1	-0.1	-0.9	-1.1
Bone: trabecular thickness	0.7	0.8	1.6	0.6	0.7	-1.0	1.3	1.2	0.8	0.8	0.8
Bone: trabecular tissue density	2.1	3.0	7.0	2.7	2.6	-1.2	1.2	1.5	1.0	-1.3	-1.5
Water consumed over 24 hours	1.1	1.5	2.9	-1.1	-1.2	1.7	-1.5	-1.4	-1.6	0.2	-0.1
Number of responses in last shaping day	0.3	0.3	0.6	0.1	0.1	0.8	-0.7	-0.4	-0.6	-0.6	-0.6