Hub : Genes

Dpf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Dpf2 0.03 0.03 9.7e-03 0.01 0.01 0 0 1.4e-02 1.6e-02 1.2e-01 1.3e-01
2 Liver gene expression Dpf2 0.1 0.05 5.2e-10 0.08 0.07 0.07 0.07 3.5e-09 2.3e-08 3.4e-08 1.0e-08
3 Adipose gene expression Dpf2 0.06 0.03 5.2e-06 0.04 0.04 0.04 0.04 2.8e-05 3.8e-05 1.7e-05 2.8e-05
4 PL isoform ratio NM_001108516.1 0.04 0.03 7.7e-05 0.03 0.03 0.03 0.03 1.7e-04 3.1e-04 4.9e-04 1.4e-04
5 Adipose mRNA stability Dpf2 0.12 0.06 2.1e-11 0.09 0.07 0.08 0.09 3.5e-10 1.4e-08 3.8e-09 9.7e-10
6 Brain mRNA stability Dpf2 0.1 0.05 1.7e-06 0.07 0.06 0.07 0.07 4.2e-07 4.5e-06 4.7e-07 2.9e-07
7 PL intron excision ratio chr1_203189376_203190858 0.03 0.02 1.4e-03 0.02 0.02 0.01 0.01 4.0e-03 6.8e-03 2.0e-02 8.6e-03
8 PL isoform ratio XM_006230850.3 0.03 0.02 7.2e-04 0.03 0.02 0.02 0.03 3.3e-04 2.3e-03 1.7e-03 2.1e-04
9 PL mRNA stability Dpf2 0.03 0.02 5.0e-03 0.03 0.01 0.02 0.02 6.9e-04 1.6e-02 4.4e-03 1.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.81.44.5-0.60.50.80.9-1.02.1-0.3-0.8-2.0
Area under the delay curve0.70.72.10.1-0.2-1.10.7-0.80.4-0.9-1.4-0.8
BMI with tail2.99.326.5-2.92.83.21.6-1.35.1-1.5-1.2-4.8
BMI without tail1.22.57.5-1.61.71.80.5-0.52.7-0.5-0.3-2.4
Body weight2.18.718.1-4.24.24.2-1.21.63.01.31.4-2.9
Weight adjusted by age1.51.73.0-1.71.51.7-1.21.30.61.41.2-0.5
Bone surface2.84.99.4-2.82.73.1-0.60.32.91.50.7-2.8
Bone volume1.42.47.1-1.51.41.80.2-0.62.70.6-0.2-2.6
Breakpoint value in progressive ratio session1.82.03.6-1.81.91.6-1.21.01.31.70.7-1.1
Number of licking bursts0.20.20.5-0.50.60.7-0.40.10.60.20.3-0.5
Context. condit. distance diff. score1.41.62.81.7-1.4-1.71.4-1.1-0.5-1.2-1.30.5
Locomotion velocity, session 10.20.20.7-0.10.20.2-0.20.8-0.80.30.50.8
Locomotion distance, session 10.50.61.5-0.80.70.80.6-0.21.2-0.7-0.3-1.2
Locomotion velocity, session 21.72.04.8-2.02.22.0-0.50.61.50.50.6-1.5
Locomotion distance, session 20.40.61.2-1.01.00.80.40.11.1-0.6-0.2-1.1
Locomotion velocity, session 30.70.82.00.4-0.5-0.11.4-1.00.8-1.2-1.0-0.7
Locomotion distance, session 30.10.10.20.2-0.1-0.30.4-0.1-0.1-0.3-0.40.1
Stereotopy head waving bouts, day 31.11.33.50.8-0.9-0.51.9-1.00.5-1.8-1.3-0.4
Stereotopy head waving duration, day 30.60.71.50.9-1.0-0.51.2-0.90.3-1.2-0.8-0.2
Locomotion velocity, session 72.42.65.20.7-0.7-0.82.3-1.81.5-2.0-2.2-1.4
Locomotion distance, session 70.60.82.10.3-0.4-0.71.5-0.70.5-1.2-1.4-0.5
Stereotopy head waving bouts, day 70.40.51.00.4-0.5-0.00.8-1.00.9-0.6-0.7-0.9
Stereotopy head waving duration, day 71.01.23.1-1.11.01.5-0.3-0.31.80.40.3-1.7
Locomotion velocity, session 80.91.12.2-1.11.21.2-0.71.5-0.71.01.10.7
Locomotion distance, session 80.71.12.90.5-0.3-0.61.7-0.90.7-1.4-1.4-0.7
Degree of sensitization distance0.60.61.50.1-0.2-0.31.2-0.70.7-1.0-1.1-0.7
Degree of sensitization stereotypy0.60.61.9-0.70.61.0-0.2-0.41.40.40.1-1.3
Conditioned locomotion1.11.32.2-1.51.41.5-0.91.20.21.11.1-0.2
Cocaine response after cond. corrected1.11.22.11.4-1.4-1.31.0-0.5-1.1-1.1-0.71.0
Cocaine response after cond. not corrected0.80.91.51.2-1.2-1.10.9-0.5-0.9-1.1-0.50.8
Cocaine response before conditioning0.40.51.1-0.91.10.9-0.60.30.70.50.5-0.8
Saline control response2.22.96.1-2.52.42.3-1.31.80.71.01.5-0.6
Bone: connectivity density1.52.45.8-1.81.81.90.1-0.12.40.80.0-2.3
Bone: cortical apparent density0.20.30.9-0.60.70.5-1.00.50.00.40.6-0.1
Bone: cortical area0.40.71.4-1.01.01.2-0.50.50.60.80.7-0.6
Bone: cortical porosity0.30.31.0-0.30.40.60.0-0.41.0-0.10.1-0.9
Bone: cortical porosity0.50.61.3-0.81.01.2-0.50.11.00.30.5-0.8
Bone: cortical thickness2.33.75.4-2.22.21.9-2.22.2-0.32.32.20.4
Bone: cortical thickness1.11.32.3-0.80.70.6-1.31.5-1.11.41.31.1
Bone: cortical tissue density0.30.41.2-0.70.80.5-1.10.6-0.00.60.80.0
Condit. Reinf. active minus inactive responses0.10.10.3-0.40.40.20.0-0.00.6-0.5-0.1-0.6
Condit. Reinf. active-inactive response ratio0.00.10.2-0.10.10.1-0.50.10.20.20.3-0.2
Condit. Reinf. active responses0.30.40.8-0.10.10.10.6-0.60.9-0.8-0.6-0.9
Condit. Reinf. inactive responses0.70.91.80.3-0.3-0.21.4-1.11.0-1.1-1.2-1.0
Incentive salience index mean0.40.51.3-0.50.60.50.3-0.31.1-0.7-0.4-1.1
Condit. Reinf. lever presses0.30.41.1-0.60.70.80.3-0.21.0-0.2-0.1-1.0
Condit. Reinf. active minus inactive responses0.30.40.80.3-0.5-0.60.6-0.70.5-0.6-0.9-0.6
Condit. Reinf. active-inactive response ratio1.21.32.20.8-1.0-0.81.4-1.40.8-1.2-1.5-0.8
Condit. Reinf. active responses0.20.30.8-0.2-0.0-0.10.2-0.50.8-0.4-0.6-0.9
Condit. Reinf. inactive responses0.10.20.4-0.70.60.4-0.50.20.40.10.2-0.5
Condit. Reinf. lever presses1.31.73.3-1.81.81.6-0.90.61.31.10.6-1.4
Condit. Reinf. lever reinforcers received0.20.30.9-0.60.40.2-0.3-0.10.9-0.0-0.2-1.0
Conditioned reinforcement - actives0.10.10.30.6-0.5-0.30.1-0.1-0.40.30.00.5
Conditioned reinforcement - inactives4.04.510.22.9-2.9-3.21.4-2.0-1.3-0.9-1.91.2
Conditioned locomotion4.75.711.83.4-3.3-3.11.3-1.6-2.4-1.5-1.22.3
Patch foraging indifference point 0 sec0.10.10.30.3-0.2-0.20.5-0.40.10.1-0.4-0.1
Patch foraging indifference point AUC2.93.35.7-2.32.32.1-1.81.41.02.41.5-0.8
Delay disc. indifference point, 0s delay0.80.92.40.5-0.5-1.31.2-0.8-0.0-1.2-1.5-0.4
Delay disc. indifference point, 16s delay1.51.52.91.0-1.1-1.51.1-1.50.7-1.4-1.7-0.5
Delay disc. indifference point, 2s delay0.20.20.40.3-0.3-0.30.5-0.60.3-0.6-0.5-0.3
Delay disc. indifference point, 24s delay0.20.20.60.3-0.3-0.8-0.10.4-0.8-0.0-0.20.7
Delay disc. indifference point, 4s delay0.40.41.20.3-0.4-0.90.7-0.5-0.2-1.1-0.9-0.2
Delay disc. indifference point, 8s delay0.40.41.6-0.0-0.1-1.30.5-0.2-0.3-0.5-1.2-0.3
Indifference point function ln k6.38.815.13.8-3.9-3.62.8-2.0-2.1-3.3-2.32.0
Indifference point function log k6.38.815.13.8-3.9-3.62.8-2.0-2.1-3.3-2.32.0
Patch foraging total patch changes 0 sec0.00.10.20.2-0.1-0.10.20.1-0.40.3-0.00.5
Patch foraging total patch changes 12 sec3.24.17.6-2.62.82.6-1.61.31.62.31.4-1.3
Patch foraging total patch changes 18 sec0.40.61.2-0.91.11.0-0.10.01.00.60.1-0.9
Patch foraging total patch changes 24 sec2.02.54.6-1.92.11.8-1.41.80.11.81.50.1
Patch foraging total patch changes 6 sec0.50.71.7-1.11.31.1-0.10.60.71.00.3-0.5
Patch foraging time to switch 0 sec1.82.88.4-1.61.61.70.3-0.82.9-0.2-0.4-2.8
Patch foraging water rate 0 sec2.74.49.62.6-2.6-2.60.5-0.0-3.1-0.5-0.33.0
Patch foraging water rate 12 sec5.68.617.53.7-3.8-3.50.9-0.1-4.2-1.3-0.44.1
Patch foraging water rate 18 sec2.33.15.22.2-2.2-2.31.3-0.3-2.3-1.3-0.92.0
Patch foraging water rate 24 sec2.63.77.12.3-2.4-2.40.9-0.1-2.7-1.1-0.52.6
Patch foraging water rate 6 sec3.14.510.42.5-2.5-2.40.70.1-3.2-1.2-0.23.1
Seeking ratio, delayed vs. immediate footshock0.40.50.90.3-0.2-0.40.7-0.90.7-0.9-0.9-0.7
Distance traveled before self-admin0.50.61.0-1.00.91.0-0.70.20.80.60.5-0.8
Distance traveled after self-admin0.40.40.9-0.70.50.7-1.00.10.50.80.8-0.4
Extensor digitorum longus weight4.517.634.8-5.95.85.9-2.93.03.23.13.0-3.1
Bone: elastic displacement1.71.96.01.1-1.3-1.3-0.30.8-2.40.10.52.4
Bone: elastic work0.91.22.6-0.90.80.8-1.11.6-1.11.01.31.0
Bone: endosteal estimation1.43.16.51.3-1.4-0.62.5-2.21.3-2.4-1.9-1.4
Bone: endosteal perimeter1.63.46.31.5-1.6-0.72.5-2.51.5-2.1-2.0-1.5
Epididymis fat weight2.04.76.82.5-2.5-2.52.6-2.4-0.4-2.2-2.40.3
Delta time in closed arm before/after self-admin0.20.20.80.10.0-0.3-0.00.7-0.90.10.10.8
Delta time in open arm before/after self-admin0.20.20.7-0.60.20.2-0.6-0.00.30.80.2-0.3
Diff in mean of infusions in LGA sessions0.50.52.1-0.90.6-0.1-0.70.8-0.21.40.10.3
Delay discount exponential model param0.50.51.6-0.10.11.0-0.50.6-0.30.81.30.7
Extinction: sum of active levers before priming3.03.05.3-2.32.22.2-0.80.52.31.10.6-2.1
Active lever presses in extinction session 62.22.14.5-1.71.71.5-1.41.70.22.11.3-0.1
Bone: final force1.82.96.2-2.42.42.5-0.91.01.51.21.1-1.5
Bone: final moment1.62.65.6-2.22.22.4-0.80.91.41.21.1-1.4
Food consumed during 24 hour testing period0.30.31.0-0.20.3-0.1-0.70.6-0.51.00.40.5
Glucose2.13.25.61.7-1.8-1.62.4-2.20.8-2.0-2.2-0.7
Heart weight2.83.96.42.4-2.3-2.52.1-1.6-1.1-2.1-2.00.8
Delay discount hyperbolic model param0.40.41.2-0.00.10.9-0.50.6-0.30.71.10.6
Intermittent access intake day 1-15 change0.50.51.31.0-0.8-0.8-0.20.0-1.00.30.11.1
Intermittent access intake escalation0.40.41.01.0-0.8-0.90.2-0.3-0.60.0-0.30.8
Intermittent access intake escalation 20.30.30.70.5-0.4-0.4-0.70.3-0.70.70.40.8
Intermitt. access day 1 inactive lever presses1.61.73.21.7-1.8-1.81.1-1.5-0.6-0.8-1.20.3
Intermitt. access day 15 inactive lever presses1.92.14.31.8-1.9-2.11.2-1.5-0.6-1.0-1.50.3
Intermitt. access escalation Index3.43.05.01.7-1.8-2.02.0-1.9-0.2-2.2-2.00.0
Intermittent access day 1 total infusions6.27.212.12.7-2.6-2.63.5-3.50.6-3.0-3.3-0.7
Intermittent access day 15 total infusions6.37.111.73.4-3.3-3.22.9-2.9-0.7-2.3-2.80.7
Intermittent access terminal intake (last 3 days)4.95.37.82.8-2.7-2.62.7-2.8-0.2-2.0-2.60.2
Intermittent access total infusions4.95.59.12.5-2.4-2.43.0-3.00.3-2.2-2.9-0.4
Intermittent access day 1 locomotion5.05.29.42.1-2.1-1.93.1-2.90.5-2.9-2.7-0.8
Intermittent access day 15 total locomotion4.14.46.92.6-2.5-2.52.2-2.5-0.5-1.9-2.20.3
Intermittent access total locomotion6.87.813.72.8-2.8-2.73.5-3.70.6-2.9-3.4-0.8
Intermittent access standard deviation0.70.81.71.2-1.2-1.30.3-0.5-1.1-0.1-0.40.9
Left kidney weight0.41.11.91.4-1.3-1.31.2-1.2-0.1-0.8-1.10.0
Right kidney weight0.00.10.30.5-0.3-0.50.1-0.3-0.20.4-0.30.1
Cocaine induced anxiety0.00.00.1-0.00.00.2-0.10.10.00.30.20.1
Post-drug Anxiety1.51.63.8-1.21.22.0-1.21.30.21.11.80.0
Baseline Anxiety1.71.93.2-1.61.61.8-1.31.60.21.31.5-0.1
Tail length1.44.47.7-1.51.51.3-2.62.8-1.62.62.61.6
Length with tail1.86.59.7-3.03.02.7-2.83.1-0.52.82.80.3
Length without tail1.32.85.7-2.42.32.2-1.31.90.31.31.4-0.6
Times rat made contact with spout0.30.30.6-0.70.70.6-0.80.40.30.40.5-0.3
Lifetime Intake4.65.28.82.4-2.3-2.33.0-2.90.4-2.2-2.8-0.5
Liver weight, left0.00.00.10.2-0.30.10.2-0.20.3-0.2-0.0-0.0
Liver weight, right0.10.20.50.3-0.4-0.00.70.2-0.6-0.7-0.20.6
Locomotor activity1.62.57.01.8-1.7-1.80.40.3-2.6-0.4-0.12.4
Locomotor testing distance2.23.610.32.1-2.1-1.90.30.5-3.2-0.70.23.0
Locomotor testing rearing1.52.45.81.9-2.0-1.80.4-0.0-2.4-0.5-0.12.1
Locomotion in novel chamber3.34.17.42.5-2.5-2.72.2-1.9-0.9-1.5-2.20.8
Locomotion in novel chamber post-restriction2.32.85.42.1-2.0-2.31.6-1.5-0.8-1.3-1.80.7
Fecal boli incidents, locomotor time 10.20.20.6-0.20.20.1-0.0-0.60.80.5-0.3-0.8
Change in fecal boli incidents, locomotor task0.20.20.6-0.0-0.10.00.70.2-0.2-0.8-0.30.2
Time >=10cm from walls, locomotor time 13.13.27.60.8-0.8-1.32.4-2.21.2-1.8-2.8-1.5
Bouts of movement, locomotor time 11.21.33.4-1.51.40.3-1.91.30.41.40.6-0.5
Total resting periods, locomotor time 10.80.92.1-1.31.10.2-1.50.80.61.00.3-0.7
Rest time, locomotor task time 10.80.92.31.1-1.2-1.50.3-0.1-1.3-0.5-0.51.1
Distance moved, locomotor task time 10.40.51.0-0.20.20.50.9-0.71.0-0.4-0.5-1.0
Vertical activity count, locomotor time 10.91.01.91.3-1.4-1.11.1-0.8-0.5-0.7-0.80.6
Time >=10cm from walls, locomotor time 20.10.10.5-0.30.30.2-0.2-0.40.50.1-0.1-0.7
Bouts of movement, locomotor time 20.30.31.0-0.70.70.4-1.00.20.50.40.3-0.6
Total resting periods, locomotor time 20.20.20.6-0.50.50.1-0.7-0.20.50.0-0.1-0.8
Rest time, locomotor task time 21.71.94.81.6-1.6-2.21.1-1.2-0.8-1.3-1.60.4
Distance moved, locomotor task time 21.11.32.8-1.21.21.7-1.01.10.31.21.4-0.2
Vertical activity count, locomotor time 21.11.23.30.2-0.20.4-0.71.4-1.50.61.41.8
Light reinforcement 10.20.30.90.5-0.3-0.6-0.30.2-0.80.60.20.9
Light reinforcement 20.50.61.41.0-1.0-1.20.8-0.7-0.2-0.4-0.90.3
Bone: marrow area1.53.36.71.4-1.4-0.62.6-2.31.3-2.5-1.9-1.4
Bone: maximum diameter0.10.30.9-0.60.51.0-0.10.10.50.40.4-0.6
Bone: maximum force2.34.07.7-2.52.52.7-0.20.12.80.50.4-2.8
Bone: maximum moment2.03.46.7-2.32.32.5-0.10.12.60.50.3-2.6
Mean time between licks in bursts0.70.91.9-0.70.81.0-0.91.4-0.90.51.30.9
Mean num. licks in bursts0.10.10.40.4-0.5-0.60.1-0.1-0.4-0.2-0.10.4
Cd content in liver0.70.81.91.2-1.1-1.40.3-0.4-1.00.1-0.50.9
Co content in liver1.51.85.01.3-1.1-1.6-0.50.6-2.20.20.42.2
Cu content in liver0.30.30.9-0.60.50.5-0.3-0.21.00.40.2-0.9
Fe content in liver0.10.10.2-0.40.30.4-0.00.4-0.10.10.20.1
K content in liver1.31.33.3-1.31.31.50.4-0.21.8-0.1-0.1-1.7
Mg content in liver1.51.64.2-0.30.20.41.1-1.32.0-1.3-1.0-2.0
Mn content in liver1.61.83.4-1.81.81.8-1.10.81.11.01.0-1.1
Na content in liver1.11.22.2-1.21.21.5-1.00.90.21.51.2-0.2
Rb content in liver1.41.72.81.5-1.6-1.31.5-1.70.4-1.3-1.4-0.4
Se content in liver0.20.30.70.0-0.10.00.3-0.70.8-0.2-0.5-0.9
Sr content in liver3.53.25.3-1.91.91.8-2.21.9-0.22.32.00.3
Zn content in liver0.80.91.5-1.21.21.1-0.60.21.20.60.4-1.1
Bone: minimum diameter1.83.46.41.2-1.3-0.52.2-2.51.9-2.2-1.9-1.9
Time in familiar zone, hab. session 10.50.51.20.6-0.7-0.40.8-0.90.4-1.1-0.7-0.4
Time in novel zone, hab. session 10.70.72.30.3-0.2-0.6-0.30.8-1.50.70.31.4
Total zone transitions, hab. session 10.40.51.0-1.00.90.8-0.40.20.90.40.2-0.9
Total locomotion distance, hab. session 10.71.01.90.6-0.7-0.81.4-1.10.6-1.1-1.4-0.7
Locomotion velocity, hab. session 10.30.40.70.1-0.2-0.20.9-0.70.8-0.6-0.9-0.8
Time in familiar zone, hab. session 20.50.51.80.2-0.20.1-0.20.9-1.30.10.71.3
Time in novel zone, hab. session 20.40.41.4-0.40.30.20.1-0.61.2-0.1-0.5-1.2
Total zone transitions, hab. session 21.41.84.7-1.41.41.40.5-0.52.2-0.8-0.4-2.2
Total locomotion distance, hab. session 21.11.43.2-0.0-0.0-0.11.5-1.21.4-1.8-1.4-1.4
Locomotion velocity, hab. session 21.41.83.80.2-0.2-0.31.7-1.41.5-2.0-1.6-1.5
Novel to familiar place preference ratio0.91.02.4-1.21.01.0-0.6-0.01.60.40.1-1.6
Novelty place preference0.60.61.8-0.80.60.6-0.4-0.31.30.3-0.0-1.3
Time in novel zone, NPP test0.40.41.3-0.70.50.5-0.4-0.21.10.2-0.0-1.1
Total zone transitions, NPP test1.52.14.0-2.02.01.9-0.50.51.60.80.5-1.7
Total locomotion distance, NPP test0.40.51.1-0.30.30.10.8-0.61.1-0.7-0.9-1.1
Locomotion velocity, NPP test0.40.51.4-0.40.30.10.6-0.61.1-0.5-0.8-1.2
Intraocular pressure0.50.71.21.0-1.0-1.1-0.3-0.2-1.10.70.01.0
Delta distance traveled before/after self-admin0.10.10.40.1-0.2-0.3-0.20.3-0.40.10.20.6
Delta ambulatory time before/after self-admin0.10.20.60.1-0.1-0.2-0.40.5-0.50.20.30.7
Parametrial fat weight2.65.18.72.2-2.2-1.92.7-3.01.1-2.7-2.6-1.1
Pavlov. Cond. lever latency0.30.30.90.6-0.7-0.6-0.30.1-0.90.40.10.9
Pavlov. Cond. magazine entry latency0.70.93.0-0.50.40.30.4-0.81.7-0.7-0.7-1.7
Pavlov. Cond. change in total contacts0.60.62.3-0.20.20.20.2-0.91.5-0.4-0.5-1.5
Pavlov. Cond. index score0.20.20.6-0.40.40.2-0.1-0.10.8-0.0-0.1-0.8
Pavlov. Cond. latency score0.20.20.7-0.30.30.10.2-0.30.8-0.4-0.3-0.8
Pavlov. Cond. lever contacts0.10.10.2-0.10.1-0.00.4-0.20.4-0.5-0.3-0.5
Pavlov. Cond. magazine entry number0.20.30.50.6-0.5-0.20.6-0.1-0.7-0.6-0.20.7
Pavlov. Cond. intertrial magazine entries0.30.40.90.9-0.8-0.9-0.1-0.4-0.7-0.0-0.20.7
Pavlov. Cond. lever-magazine prob. diff.0.30.41.1-0.70.60.5-0.1-0.11.10.0-0.1-1.0
Pavlov. Cond. response bias0.10.10.3-0.30.3-0.0-0.2-0.10.60.2-0.1-0.6
Pavlov. Cond. lever latency0.30.40.80.9-0.9-0.80.1-0.2-0.8-0.5-0.00.9
Pavlov. Cond. magazine entry latency2.32.74.8-2.12.02.2-1.20.71.71.41.0-1.7
Pavlov. Cond. change in total contacts1.52.14.7-1.71.61.5-0.7-0.12.11.10.2-2.2
Pavlov. Cond. index score1.62.13.6-1.91.81.9-0.80.41.81.10.5-1.8
Pavlov. Cond. latency score1.41.73.0-1.71.61.7-0.60.21.70.90.4-1.7
Pavlov. Cond. lever contacts0.40.51.2-0.90.90.7-0.60.60.11.10.5-0.2
Pavlov. Cond. magazine entry number4.35.29.33.0-2.8-3.01.8-1.1-2.2-1.9-1.52.2
Pavlov. Cond. intertrial magazine entries0.70.91.71.3-1.1-1.30.9-0.7-0.7-0.9-0.90.6
Pavlov. Cond. lever-magazine prob. diff.1.92.54.4-2.12.02.0-1.00.51.91.20.7-1.8
Pavlov. Cond. response bias1.21.73.0-1.71.71.6-1.10.81.01.50.8-1.1
Time in closed arm before self-admin0.20.20.5-0.40.20.60.1-0.40.7-0.10.1-0.7
Time in closed arm after self-admin0.20.20.50.3-0.3-0.30.6-0.3-0.0-0.7-0.60.0
Time in open arm before self-admin0.50.61.41.2-0.8-0.80.20.1-1.1-0.60.01.0
Time in open arm after self-admin0.40.40.90.5-0.4-0.3-0.70.4-1.00.70.70.9
Bone: periosteal estimation0.40.71.40.1-0.20.51.1-1.01.2-0.9-0.6-1.2
Bone: periosteal perimeter0.20.41.2-0.30.20.80.5-0.51.1-0.2-0.1-1.1
Bone: post-yield work5.98.022.6-0.60.71.12.4-3.04.8-2.3-2.4-4.6
Progressive ratio test 1 active lever presses1.81.93.71.9-1.9-1.91.2-1.5-0.7-0.7-1.20.7
Progressive ratio test 1 breakpoint1.51.63.41.8-1.8-1.70.9-1.2-0.8-0.5-0.90.8
Progressive ratio test 1 inactive lever presses1.01.12.51.3-1.3-1.61.0-1.1-0.5-0.4-1.20.3
Progressive ratio test 2 active lever presses3.13.36.42.5-2.4-2.21.8-2.1-0.6-1.3-1.80.6
Progressive ratio test 2 breakpoint3.53.98.02.8-2.7-2.61.7-1.9-1.2-1.2-1.61.2
Progressive ratio test 2 inactive lever presses6.27.212.73.6-3.4-3.32.7-3.1-0.7-2.2-2.60.6
Incentive Sensitization - Responses0.50.51.00.9-0.8-0.60.9-1.00.3-0.5-0.8-0.1
Incentive Sensitization - Breakpoint0.70.71.31.1-1.0-0.80.9-1.10.1-0.6-0.90.0
Sum of active levers in priming session hrs 5-61.71.74.7-1.31.21.0-1.61.5-0.12.21.20.3
Progressive ratio2.12.56.6-1.71.71.60.5-0.52.5-0.4-0.6-2.6
Food seeking constrained by brief footshock0.20.30.6-0.30.30.6-0.40.8-0.40.20.80.5
Seeking ratio, punishment vs. effort1.92.36.61.7-1.6-1.4-0.30.6-2.5-0.10.62.6
Retroperitoneal fat weight4.113.421.34.6-4.6-4.24.0-3.8-0.8-3.9-3.70.7
Reaction time number correct0.60.92.2-0.90.80.6-0.71.5-0.81.10.90.7
Reaction time mean minus median1.72.24.5-2.12.11.8-1.00.51.70.60.5-1.8
Reaction time mean minus median AUC0.91.22.4-1.61.61.3-1.10.80.60.70.7-0.8
Reaction time num false alarms0.40.61.50.8-0.7-0.50.40.2-1.2-0.6-0.01.2
Reaction time num false alarms AUC0.20.20.80.10.00.00.00.6-0.9-0.20.30.8
Reaction time trials correct on left0.60.92.2-0.90.80.6-0.71.5-0.81.10.90.7
Reaction time trials on left0.71.02.5-1.00.90.7-0.81.6-0.81.21.00.7
Reaction time mean0.10.20.5-0.30.3-0.1-0.2-0.40.6-0.2-0.3-0.7
Reaction time mean AUC0.20.30.9-0.20.2-0.2-0.0-0.60.8-0.4-0.5-0.9
Median of all reaction times0.10.20.50.1-0.2-0.40.1-0.70.5-0.4-0.5-0.6
Reaction time omissions0.70.92.3-1.51.31.0-0.80.80.70.50.4-0.9
Reaction time false alarm rate0.30.40.90.9-0.7-0.50.6-0.3-0.6-0.9-0.30.6
Reaction time premature initiation rate2.33.05.0-1.81.92.0-1.92.2-0.61.42.20.6
Reaction time premature initiations4.05.69.9-2.52.52.5-2.63.1-1.02.32.80.8
Std. dev. reaction times0.50.61.4-1.21.20.8-0.60.20.90.20.1-1.1
Reaction time trials completed0.71.02.5-1.00.90.7-0.81.6-0.81.21.00.7
Reaction time trials AUC0.50.71.9-0.80.60.5-0.61.4-0.81.00.80.7
Run reversals in cocaine runway, females0.90.91.9-0.60.60.51.0-0.61.3-1.2-0.9-1.4
Run reversals in cocaine runway, males1.21.13.20.6-0.5-0.3-0.81.0-1.80.81.01.8
Latency to leave start box in cocaine runway0.70.81.50.2-0.2-0.11.0-1.21.2-0.9-1.0-1.1
Latency to leave start box in cocaine runway, F0.30.30.9-0.00.00.20.2-0.81.0-0.6-0.3-1.0
Latency to leave start box in cocaine runway, M0.20.10.50.1-0.2-0.10.7-0.40.3-0.2-0.6-0.2
Std. dev. time between licks in bursts0.60.72.10.3-0.20.1-0.40.8-1.5-0.10.91.4
Total sessions with >9 infusions2.12.34.81.5-1.5-1.42.2-1.80.1-1.8-1.9-0.2
Short access day 1 total inactive lever presses2.83.15.22.1-2.3-2.21.7-2.0-0.6-1.8-1.70.2
Short access day 10 total inactive lever presses2.32.54.92.1-2.2-2.01.1-1.2-1.4-1.5-1.01.1
Short access day 1 total infusions4.14.37.21.7-1.8-2.02.6-2.70.7-2.5-2.6-0.8
Short access day 10 total infusions4.65.110.11.4-1.4-1.63.2-2.91.5-2.4-3.2-1.6
Short access total infusions2.62.96.31.3-1.3-1.42.5-2.20.7-1.9-2.3-0.8
Short access day 1 locomotion3.33.66.61.8-1.8-1.62.5-2.30.3-2.6-2.2-0.4
Short access day 10 total locomotion2.52.74.91.4-1.5-1.32.2-2.20.5-2.1-2.0-0.9
Short access total locomotion2.22.34.31.2-1.3-1.12.1-2.00.5-2.0-1.8-0.8
One hour access (0.3 mA shock)6.88.014.83.8-3.7-3.72.6-2.7-1.7-2.1-2.51.5
Compulsive drug intake2.92.94.8-1.81.71.6-2.22.2-0.31.92.10.4
One hour access (shock baseline)6.47.413.13.6-3.5-3.52.6-3.0-1.0-2.1-2.70.9
Social response proportion0.60.71.4-1.01.11.2-0.80.40.50.50.7-0.7
Social responses0.30.40.7-0.50.40.5-0.80.8-0.40.80.80.4
Social time0.70.91.7-0.80.70.9-0.91.2-0.41.31.20.5
Soleus weight2.57.313.83.7-3.7-3.42.5-2.3-1.4-2.5-2.21.4
Bone: stiffness2.23.47.6-2.22.22.4-0.2-0.12.80.70.2-2.7
Tibialis anterior weight7.023.843.6-6.66.66.4-4.24.71.74.74.3-1.7
Time to tail flick, vehicle, before self-admin0.50.51.1-0.60.70.20.8-0.10.9-0.8-0.9-1.1
Time to tail flick, vehicle, after self-admin0.60.71.6-0.81.31.10.20.41.10.0-0.0-1.1
Time to tail flick, test, before self-admin1.91.84.30.9-0.8-1.12.1-1.40.4-1.8-1.9-0.7
Time to tail flick, test, after self-admin0.10.10.2-0.00.2-0.1-0.10.5-0.30.10.00.3
Delta time to tail flick, vehicle, before/after SA0.20.20.6-0.50.70.8-0.30.30.50.40.4-0.5
Delta time to tail flick, test, before/after SA3.12.85.4-0.81.21.2-2.32.1-0.92.22.21.1
Tibia length0.82.33.8-1.91.81.9-1.41.01.01.91.3-0.9
Ambulatory time before self-admin0.40.40.9-0.70.70.6-0.4-0.11.00.50.1-0.9
Ambulatory time after self-admin0.30.31.0-0.2-0.3-0.10.1-1.01.0-0.2-0.5-0.8
Bone: tissue strength0.10.10.3-0.10.40.10.2-0.20.6-0.3-0.3-0.5
Total heroin consumption4.04.78.9-2.82.83.0-1.91.51.62.01.9-1.4
Bone: trabecular number0.81.24.1-0.70.50.70.7-0.82.00.1-0.8-1.9
Bone: trabecular spacing0.20.31.00.5-0.3-0.6-0.00.3-1.0-0.30.10.9
Bone: trabecular thickness0.81.01.90.9-1.0-0.81.0-1.40.9-0.9-1.1-0.8
Bone: trabecular tissue density1.92.75.72.4-2.3-2.11.0-1.2-1.3-1.4-1.01.2
Water consumed over 24 hours0.91.12.6-1.11.10.8-1.61.1-0.11.31.20.1
Number of responses in last shaping day0.80.91.91.2-1.3-1.00.1-0.2-1.4-0.30.11.2