Hub : Genes

Pkia

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative TSS XM_008760857.3 0.03 0.02 2.6e-03 0.01 0 -0 0 3.3e-02 1.2e-01 4.5e-01 1.8e-01
2 pVTA mRNA stability Pkia 0.07 0.05 8.9e-03 0 0.03 -0.01 0 2.9e-01 1.8e-02 7.5e-01 2.1e-01
3 BLA mRNA stability Pkia 0.05 0.03 3.9e-03 0.05 0.04 0.05 0.04 1.6e-03 4.6e-03 1.3e-03 3.1e-03
4 Adipose gene expression Pkia 0.07 0.04 1.1e-06 0.04 0.04 0.04 0.04 1.3e-05 3.0e-05 2.3e-05 1.8e-05
5 Brain alternative TSS XM_039101565.1 0.05 0.04 2.6e-03 -0 0.01 0.01 0 6.4e-01 1.6e-02 1.6e-02 2.7e-01
6 RMTg mRNA stability Pkia 0.23 0.11 1.9e-04 0.05 0.04 0.01 0.03 1.8e-02 2.5e-02 1.5e-01 6.7e-02
7 Brain alternative polyA NM_053772.2 0.07 0.05 2.9e-03 0.02 0.02 0.01 0.01 8.9e-03 8.9e-03 1.5e-02 1.9e-02
8 Brain gene expression Pkia 0.05 0.03 3.1e-05 0.03 0.04 0.02 0.03 1.3e-03 2.9e-04 2.4e-03 1.8e-03
9 Brain alternative polyA XM_006232155.4 0.07 0.05 2.7e-03 0.02 0.02 0.01 0.01 1.0e-02 7.0e-03 1.6e-02 1.9e-02
10 NAcc isoform ratio NM_053772.2 0.03 0.02 1.1e-03 0.01 0.01 0.01 0.01 2.0e-02 1.2e-02 9.8e-03 1.3e-02
11 IL mRNA stability Pkia 0.24 0.14 1.6e-03 0.06 0.04 0.04 0.07 1.8e-02 3.4e-02 3.7e-02 8.3e-03
12 IL gene expression Pkia 0.19 0.12 3.9e-03 0.05 0.06 -0.01 0.05 2.4e-02 1.4e-02 9.7e-01 2.3e-02
13 LHb mRNA stability Pkia 0.26 0.13 1.1e-03 -0.01 0.03 0 0.01 7.3e-01 6.6e-02 3.3e-01 1.4e-01
14 NAcc mRNA stability Pkia 0.05 0.03 1.7e-07 0.05 0.03 0.03 0.04 2.6e-06 2.5e-04 8.5e-05 6.0e-05
15 PL mRNA stability Pkia 0.12 0.06 6.8e-13 0.1 0.1 0.08 0.1 5.9e-11 7.6e-11 2.3e-09 6.7e-11
16 BLA intron excision ratio chr2_94406119_94432152 0.04 0.03 9.5e-03 0.03 0.02 0.01 0.01 1.3e-02 3.8e-02 9.1e-02 7.7e-02
17 Liver gene expression Pkia 0.05 0.03 2.3e-05 0.03 0.03 0.03 0.03 9.6e-05 1.4e-04 2.6e-04 1.2e-04
18 Brain mRNA stability Pkia 0.15 0.07 2.2e-12 0.12 0.13 0.12 0.12 1.3e-11 5.7e-12 2.0e-11 1.5e-11
19 Brain isoform ratio NM_053772.2 0.06 0.05 9.9e-04 0.03 0.04 0.04 0.03 4.8e-04 2.9e-04 5.1e-05 4.0e-04
20 PL gene expression Pkia 0.07 0.04 3.4e-06 0.04 0.04 0.05 0.05 1.7e-05 6.5e-05 1.7e-06 6.9e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bone: apparent density0.40.63.5-1.91.1-0.9-0.70.9-0.6-0.6-1.11.1-0.60.60.60.0-0.5-0.7-0.70.70.20.10.2
Area under the delay curve0.30.32.31.50.90.5-0.2-0.20.00.0-0.30.30.2-0.1-0.7-0.90.10.1-0.20.2-0.0-0.5-1.1
BMI with tail1.75.515.83.3-1.82.92.4-4.02.32.43.2-0.11.6-2.2-2.7-1.41.91.81.9-1.9-2.32.61.4
BMI without tail6.413.219.64.4-2.14.33.8-3.53.83.93.82.03.5-3.8-4.4-3.63.63.63.5-3.5-3.93.52.8
Body weight0.93.912.42.6-0.72.41.8-3.51.92.02.30.81.3-1.8-2.6-1.71.61.51.3-1.3-2.22.51.4
Weight adjusted by age0.91.02.81.20.50.91.0-0.20.91.00.21.60.9-0.8-1.3-1.70.90.80.9-0.9-1.10.71.2
Bone surface1.12.05.3-1.92.3-1.7-1.70.7-1.5-1.5-2.00.7-1.71.61.00.5-1.4-1.5-1.51.50.9-0.5-0.4
Bone volume1.01.84.9-2.21.5-1.7-1.60.9-1.3-1.3-1.60.4-1.51.51.30.8-1.2-1.4-1.41.40.9-0.5-0.4
Breakpoint value in progressive ratio session1.21.32.7-0.51.6-1.2-1.40.4-1.6-1.6-1.3-0.3-1.21.30.70.5-1.2-1.1-1.11.11.0-1.2-0.8
Number of licking bursts0.10.10.70.4-0.00.80.8-0.30.10.10.1-0.20.3-0.5-0.10.0-0.0-0.20.1-0.10.10.3-0.2
Context. condit. distance diff. score0.30.41.30.71.1-0.8-0.91.0-0.3-0.2-0.90.5-0.40.70.1-0.5-0.4-0.6-0.10.10.3-1.2-0.0
Locomotion velocity, session 10.00.00.20.40.10.0-0.0-0.3-0.10.00.1-0.30.1-0.1-0.10.0-0.00.20.2-0.20.1-0.30.0
Locomotion distance, session 10.20.32.2-0.51.5-0.3-0.4-0.9-0.6-0.5-0.50.6-0.40.2-0.3-0.3-0.1-0.1-0.20.1-0.20.30.3
Locomotion velocity, session 20.50.61.60.71.20.70.5-1.30.30.30.11.00.3-0.2-1.2-1.10.10.80.3-0.3-0.91.00.7
Locomotion distance, session 20.40.63.2-1.11.8-0.3-0.4-1.5-0.9-0.9-0.60.3-0.70.5-0.10.1-0.6-0.5-0.70.7-0.00.8-0.0
Locomotion velocity, session 30.00.00.20.0-0.40.10.20.30.00.00.1-0.50.4-0.00.20.30.10.00.1-0.10.2-0.2-0.1
Locomotion distance, session 30.20.21.3-0.91.1-0.5-0.5-0.3-0.6-0.6-0.50.4-0.30.50.0-0.1-0.2-0.3-0.30.3-0.10.20.2
Stereotopy head waving bouts, day 30.00.10.2-0.4-0.2-0.3-0.20.30.10.1-0.10.40.3-0.00.2-0.00.40.10.3-0.20.0-0.10.1
Stereotopy head waving duration, day 31.21.52.21.2-0.91.11.10.01.51.50.91.21.5-1.2-1.2-1.41.51.51.4-1.4-1.20.61.0
Locomotion velocity, session 79.810.717.4-4.23.6-4.0-3.91.4-3.6-3.5-3.7-0.5-3.83.93.22.5-3.6-3.5-3.63.62.7-1.9-1.7
Locomotion distance, session 73.84.99.4-3.12.2-2.7-2.41.4-2.5-2.5-2.5-0.6-2.42.42.41.9-2.2-2.3-2.42.41.9-1.4-1.1
Stereotopy head waving bouts, day 70.10.10.70.20.5-0.2-0.4-0.9-0.1-0.10.00.0-0.20.2-0.2-0.10.0-0.30.1-0.10.10.1-0.1
Stereotopy head waving duration, day 70.91.11.71.2-0.21.10.8-0.91.11.10.81.11.0-1.0-1.3-1.31.00.91.2-1.2-1.00.90.8
Locomotion velocity, session 80.20.31.61.10.9-0.2-0.5-1.3-0.3-0.20.1-0.4-0.50.5-0.5-0.2-0.4-0.3-0.20.2-0.0-0.1-0.3
Locomotion distance, session 80.60.95.2-0.02.3-1.0-1.2-0.2-1.0-1.0-1.30.4-1.11.20.1-0.2-1.0-1.0-0.80.80.5-0.6-0.3
Degree of sensitization distance1.01.01.8-1.10.5-1.2-1.00.9-1.0-0.9-1.1-0.6-1.21.01.41.2-1.0-1.1-1.01.01.1-0.9-0.5
Degree of sensitization stereotypy0.30.31.61.20.70.50.2-1.00.30.30.20.40.2-0.4-0.9-0.80.40.10.5-0.5-0.40.20.2
Conditioned locomotion1.92.23.5-1.10.5-1.4-1.4-0.1-1.5-1.5-0.9-1.7-1.81.61.61.8-1.8-1.5-1.81.81.6-0.9-1.9
Cocaine response after cond. corrected0.10.10.4-0.5-0.1-0.5-0.50.20.10.1-0.10.3-0.20.60.10.0-0.40.1-0.20.2-0.00.2-0.2
Cocaine response after cond. not corrected1.21.32.4-1.40.5-1.4-1.31.0-0.9-0.9-1.1-0.2-1.11.61.31.0-1.4-1.1-1.31.31.1-0.7-1.1
Cocaine response before conditioning2.83.45.2-1.71.9-1.9-1.81.4-2.0-2.0-2.3-0.8-1.91.92.01.5-1.9-2.3-2.02.02.1-1.8-1.5
Saline control response1.72.37.0-1.42.7-1.6-1.70.5-1.6-1.6-2.10.7-1.81.70.80.2-1.8-1.6-1.71.71.0-0.8-0.8
Bone: connectivity density0.81.34.4-1.82.1-1.1-1.01.1-1.0-1.0-1.81.5-1.01.00.6-0.2-0.9-1.2-1.21.20.4-0.2-0.1
Bone: cortical apparent density0.60.83.40.10.0-0.3-0.3-0.2-1.0-1.0-0.2-1.8-0.60.70.91.2-1.1-1.0-0.80.81.1-1.0-1.2
Bone: cortical area0.60.91.31.1-0.61.00.8-1.11.01.01.10.40.8-0.9-1.1-0.81.00.90.9-0.9-1.01.00.6
Bone: cortical porosity0.00.00.40.2-0.20.20.20.60.20.2-0.10.20.2-0.2-0.1-0.20.2-0.00.0-0.0-0.0-0.4-0.1
Bone: cortical porosity0.20.20.8-0.0-0.1-0.2-0.20.9-0.2-0.2-0.3-0.4-0.20.20.50.3-0.3-0.5-0.40.40.5-0.9-0.5
Bone: cortical thickness0.20.41.40.8-1.10.50.4-1.20.40.51.1-1.10.4-0.4-0.30.40.50.30.5-0.5-0.20.5-0.1
Bone: cortical thickness0.80.94.02.0-0.71.21.0-0.90.90.91.1-0.21.1-1.0-1.1-0.80.90.81.0-1.0-0.70.20.3
Bone: cortical tissue density0.60.83.30.2-0.0-0.3-0.3-0.2-0.9-1.0-0.2-1.8-0.60.70.81.2-1.1-1.0-0.80.81.1-1.0-1.2
Condit. Reinf. active minus inactive responses2.02.23.8-1.31.2-1.3-1.4-0.8-1.9-1.8-0.9-1.9-1.91.51.52.0-1.6-1.6-1.51.51.5-0.6-1.1
Condit. Reinf. active-inactive response ratio3.03.25.5-1.81.4-1.6-1.7-1.1-2.3-2.2-1.1-2.2-2.31.71.72.3-2.0-2.0-1.91.91.7-0.6-1.2
Condit. Reinf. active responses2.22.74.9-1.51.1-1.6-1.6-0.8-2.0-2.0-1.0-2.2-2.11.71.72.2-1.8-1.7-1.71.71.7-0.7-1.3
Condit. Reinf. inactive responses0.10.10.70.3-0.60.10.1-0.50.20.10.5-0.80.10.00.10.4-0.00.20.1-0.10.10.1-0.3
Incentive salience index mean0.91.12.3-0.91.5-0.8-0.9-1.1-1.4-1.3-0.8-0.8-1.50.90.71.0-1.1-1.2-1.01.00.80.1-0.5
Condit. Reinf. lever presses0.30.32.10.21.20.40.1-1.4-0.2-0.1-0.10.7-0.3-0.2-0.7-0.60.1-0.20.0-0.0-0.41.00.4
Condit. Reinf. active minus inactive responses4.45.59.3-2.21.1-2.4-2.4-0.3-2.6-2.6-1.5-2.8-2.72.62.63.1-2.5-2.6-2.52.52.5-1.5-2.2
Condit. Reinf. active-inactive response ratio2.62.77.5-1.30.1-1.3-1.4-1.6-1.7-1.7-0.2-2.7-1.91.61.72.6-1.7-1.6-1.71.71.7-0.4-1.9
Condit. Reinf. active responses4.76.58.9-2.82.1-3.0-2.80.6-2.9-2.9-2.4-1.8-3.03.02.72.6-2.7-2.8-2.82.82.5-1.6-1.9
Condit. Reinf. inactive responses1.01.22.5-1.41.6-1.6-1.41.2-1.0-1.0-1.50.5-1.11.30.80.3-0.8-1.1-1.01.00.6-0.70.0
Condit. Reinf. lever presses0.30.41.0-1.00.7-0.5-0.5-0.3-0.7-0.6-0.5-0.2-0.90.70.60.7-0.7-0.9-0.90.90.40.2-0.4
Condit. Reinf. lever reinforcers received4.15.88.0-2.72.2-2.8-2.70.6-2.7-2.7-2.3-1.5-2.82.82.52.4-2.6-2.7-2.72.72.3-1.5-1.8
Conditioned reinforcement - actives0.30.31.5-1.2-0.1-0.4-0.11.10.20.2-0.41.10.2-0.10.2-0.30.30.30.5-0.5-0.30.11.2
Conditioned reinforcement - inactives0.40.40.9-0.4-0.80.40.4-0.20.70.80.70.70.6-0.7-0.4-0.40.80.90.5-0.5-0.90.90.1
Conditioned locomotion0.20.20.5-0.40.1-0.4-0.10.6-0.5-0.2-0.5-0.5-0.40.50.70.6-0.6-0.6-0.50.50.7-0.5-0.3
Patch foraging indifference point 0 sec0.71.28.50.10.90.30.30.71.01.1-0.42.90.6-0.4-1.2-2.00.50.80.3-0.3-1.31.11.0
Patch foraging indifference point AUC0.60.75.00.52.2-0.2-0.40.6-0.5-0.4-1.41.8-0.40.4-0.5-1.3-0.4-0.3-0.40.4-0.1-0.50.0
Delay disc. indifference point, 0s delay0.20.20.91.0-0.10.3-0.3-0.10.50.50.30.50.5-0.6-0.7-0.80.60.60.3-0.3-0.50.1-0.0
Delay disc. indifference point, 16s delay0.40.41.21.1-0.41.00.6-0.70.70.70.70.10.7-0.7-0.8-0.60.60.60.3-0.3-0.60.6-0.1
Delay disc. indifference point, 2s delay1.51.74.30.31.9-1.1-2.1-0.7-1.5-1.5-1.1-0.9-1.51.40.50.6-1.4-1.4-1.41.41.1-1.1-1.6
Delay disc. indifference point, 24s delay1.51.53.60.6-0.61.71.9-0.01.31.30.81.51.5-1.4-1.3-1.41.31.30.6-0.6-1.41.20.2
Delay disc. indifference point, 4s delay0.80.85.62.40.80.8-0.2-0.60.60.60.10.80.7-0.6-1.4-1.70.70.70.6-0.6-0.7-0.1-0.2
Delay disc. indifference point, 8s delay0.30.31.01.00.80.1-0.11.0-0.1-0.1-0.70.60.2-0.1-0.3-0.9-0.0-0.0-0.20.20.2-0.9-0.8
Indifference point function ln k0.91.23.71.2-1.91.21.2-0.31.41.41.6-0.31.3-1.1-0.8-0.41.11.01.2-1.2-0.80.60.5
Indifference point function log k0.91.23.71.2-1.91.21.2-0.31.41.41.6-0.31.3-1.1-0.8-0.41.11.01.2-1.2-0.80.60.5
Patch foraging total patch changes 0 sec0.81.38.60.50.90.50.50.71.11.2-0.32.90.8-0.6-1.4-2.20.60.90.4-0.4-1.41.11.1
Patch foraging total patch changes 12 sec0.60.74.40.70.70.20.10.60.70.8-0.22.10.6-0.3-1.1-1.70.50.80.4-0.4-1.00.50.7
Patch foraging total patch changes 18 sec0.70.94.60.71.00.50.4-0.00.70.8-0.22.10.6-0.6-1.3-1.80.70.80.4-0.4-1.20.91.0
Patch foraging total patch changes 24 sec1.11.38.10.51.50.20.20.50.50.7-0.62.80.7-0.6-1.3-2.21.00.61.0-1.0-1.20.61.5
Patch foraging total patch changes 6 sec0.71.05.30.80.90.70.6-0.00.70.9-0.12.30.7-0.7-1.4-2.00.70.80.4-0.4-1.30.90.8
Patch foraging time to switch 0 sec0.61.04.7-1.0-0.4-0.9-1.0-1.7-1.0-1.00.5-2.2-0.90.80.91.8-0.4-0.7-0.40.40.70.0-0.6
Patch foraging water rate 0 sec1.01.73.11.1-0.51.61.60.81.51.40.51.81.6-1.5-1.2-1.71.31.21.2-1.2-1.20.61.2
Patch foraging water rate 12 sec1.21.84.20.6-2.11.71.8-0.61.71.71.70.41.5-1.4-1.0-0.61.01.40.9-0.9-1.31.80.9
Patch foraging water rate 18 sec1.11.42.7-0.4-1.71.31.5-0.41.21.31.30.71.4-1.4-0.7-0.41.31.21.2-1.2-1.21.61.5
Patch foraging water rate 24 sec1.42.03.10.9-1.01.21.40.81.71.70.81.71.8-1.6-1.2-1.61.81.41.6-1.6-1.40.61.7
Patch foraging water rate 6 sec0.10.21.60.10.00.10.21.30.20.2-0.40.80.5-0.3-0.0-0.50.40.20.3-0.3-0.0-0.40.3
Seeking ratio, delayed vs. immediate footshock0.70.83.6-1.90.4-0.6-0.31.6-0.6-0.6-1.30.5-0.50.61.30.7-0.8-0.8-0.90.90.8-0.2-0.2
Distance traveled before self-admin1.21.33.71.80.81.20.8-0.50.90.80.31.51.0-1.1-1.6-1.91.10.91.0-1.0-1.10.70.8
Distance traveled after self-admin0.60.72.21.50.10.80.6-0.10.70.70.30.80.8-0.8-1.0-1.20.90.71.0-1.0-0.70.10.9
Extensor digitorum longus weight1.66.323.84.8-0.62.51.4-4.91.92.03.2-0.21.4-1.8-3.6-2.22.01.92.3-2.3-2.42.01.0
Bone: elastic displacement0.20.20.8-0.7-0.90.30.6-0.00.30.30.5-0.00.3-0.40.10.30.20.50.2-0.2-0.30.90.3
Bone: elastic work0.60.82.4-0.0-1.00.80.9-0.71.01.01.10.60.7-0.8-0.8-0.50.81.10.6-0.6-1.11.50.8
Bone: endosteal estimation0.40.85.3-0.62.3-0.9-1.1-0.4-0.9-1.0-1.31.0-1.10.80.0-0.3-0.5-0.8-0.60.60.3-0.30.1
Bone: endosteal perimeter0.00.10.6-0.30.50.0-0.1-0.8-0.0-0.1-0.00.4-0.2-0.2-0.2-0.20.20.20.1-0.1-0.20.40.3
Epididymis fat weight0.40.92.7-0.10.7-0.8-0.90.8-1.0-1.0-1.0-0.7-0.90.80.90.7-0.9-1.1-0.90.91.2-1.6-1.4
Delta time in closed arm before/after self-admin1.61.52.51.2-1.01.41.4-1.61.31.31.50.41.3-1.2-1.4-0.91.31.31.1-1.1-1.31.40.6
Delta time in open arm before/after self-admin0.30.31.0-0.50.8-0.6-0.51.0-0.4-0.4-0.90.7-0.50.30.3-0.1-0.4-0.5-0.10.10.3-0.50.3
Diff in mean of infusions in LGA sessions1.11.22.30.80.21.21.2-1.31.01.00.81.50.9-0.9-1.5-1.50.91.10.9-0.9-1.51.31.3
Delay discount exponential model param0.30.31.7-1.3-1.0-0.40.2-0.10.10.10.5-0.3-0.1-0.00.50.80.10.10.3-0.3-0.10.61.2
Extinction: sum of active levers before priming0.10.10.60.30.2-0.2-0.00.6-0.2-0.1-0.30.30.00.2-0.0-0.30.00.1-0.10.10.0-0.5-0.8
Active lever presses in extinction session 60.10.10.3-0.0-0.20.20.1-0.40.40.30.40.30.2-0.1-0.4-0.30.40.40.2-0.2-0.50.5-0.1
Bone: final force0.30.42.10.51.5-0.5-0.9-1.2-0.6-0.6-0.4-0.0-1.00.7-0.3-0.1-0.6-0.6-0.50.60.2-0.1-0.4
Bone: final moment0.20.31.60.41.3-0.4-0.8-1.0-0.4-0.4-0.30.2-0.70.6-0.3-0.2-0.4-0.4-0.40.40.10.1-0.2
Food consumed during 24 hour testing period0.60.72.61.6-0.91.21.1-0.90.70.81.0-0.70.8-0.9-0.6-0.20.60.30.8-0.8-0.30.3-0.1
Glucose0.30.51.91.4-0.60.70.5-0.50.70.70.8-0.00.7-0.7-0.8-0.60.50.70.9-0.9-0.50.10.2
Heart weight0.91.35.9-0.51.4-0.6-0.62.4-0.9-0.9-1.90.8-0.40.50.8-0.2-0.9-0.9-1.01.11.0-1.9-0.9
Delay discount hyperbolic model param0.30.32.2-1.5-1.0-0.30.40.20.20.20.4-0.2-0.1-0.00.60.80.10.10.3-0.3-0.10.61.1
Intermittent access intake day 1-15 change2.52.54.1-1.30.6-1.9-1.71.4-1.9-1.7-1.5-1.5-1.51.51.91.7-1.6-1.6-1.31.31.9-2.0-0.9
Intermittent access intake escalation1.41.42.4-0.90.3-1.5-1.30.9-1.4-1.3-0.9-1.4-1.11.11.41.4-1.1-1.2-0.90.91.5-1.6-0.7
Intermittent access intake escalation 22.42.33.4-1.20.7-1.6-1.71.3-1.7-1.6-1.4-1.3-1.51.51.81.6-1.6-1.6-1.41.41.8-1.8-1.3
Intermitt. access day 1 inactive lever presses0.50.52.91.1-0.50.0-0.20.3-0.2-0.10.1-1.7-0.20.20.50.8-0.5-0.5-0.40.41.0-1.3-1.1
Intermitt. access day 15 inactive lever presses0.40.54.20.2-0.60.00.22.0-0.0-0.0-0.5-0.10.6-0.20.60.00.20.10.6-0.60.6-1.40.7
Intermitt. access escalation Index0.20.10.60.70.3-0.1-0.20.60.20.1-0.40.0-0.20.30.1-0.1-0.5-0.4-0.50.50.4-0.2-0.8
Intermittent access day 1 total infusions0.40.43.3-1.30.8-0.10.40.30.20.2-0.61.8-0.1-0.0-0.1-0.7-0.00.2-0.10.1-0.60.80.8
Intermittent access day 15 total infusions0.60.73.1-1.80.5-1.1-0.61.0-0.8-0.7-1.00.3-0.80.81.00.7-0.8-0.7-0.60.60.6-0.50.3
Intermittent access terminal intake (last 3 days)2.12.33.9-2.01.2-1.8-1.51.6-1.6-1.6-1.9-0.2-1.51.61.71.2-1.6-1.5-1.41.41.5-1.5-0.9
Intermittent access total infusions0.50.61.9-1.41.2-0.8-0.40.8-0.6-0.6-1.20.9-0.80.80.60.1-0.8-0.6-0.90.90.4-0.3-0.1
Intermittent access day 1 locomotion0.30.30.80.0-0.80.60.8-0.90.60.60.8-0.30.3-0.4-0.20.20.20.4-0.20.2-0.40.8-0.3
Intermittent access day 15 total locomotion0.40.52.5-0.5-1.60.60.8-0.80.30.41.1-1.10.3-0.40.20.90.20.4-0.20.2-0.10.6-0.7
Intermittent access total locomotion0.20.30.9-0.3-0.60.20.6-0.7-0.10.10.5-0.9-0.20.10.30.8-0.3-0.1-0.60.60.20.2-0.9
Intermittent access standard deviation1.61.73.7-0.71.4-1.5-1.31.4-1.6-1.5-1.7-0.4-1.21.41.30.7-1.3-1.3-0.90.91.5-1.9-0.3
Left kidney weight0.30.82.80.80.01.11.10.70.90.90.01.71.1-1.0-1.0-1.50.81.00.4-0.4-0.80.30.4
Right kidney weight0.10.31.01.0-0.40.50.40.90.50.50.10.60.8-0.5-0.5-0.80.50.50.2-0.2-0.2-0.6-0.3
Cocaine induced anxiety0.50.61.41.0-0.50.60.70.11.20.90.50.80.9-0.9-0.8-1.00.90.90.4-0.4-0.80.7-0.9
Post-drug Anxiety0.10.11.00.2-0.10.10.10.20.40.30.10.40.5-0.4-0.2-0.40.50.20.1-0.1-0.20.2-1.0
Baseline Anxiety1.11.23.0-1.70.8-1.0-1.21.0-1.4-1.3-1.2-0.3-0.91.11.31.0-0.9-1.2-0.50.51.1-1.20.9
Tail length0.92.65.01.4-0.01.71.5-0.91.51.61.02.11.7-1.8-2.1-2.21.81.81.6-1.6-1.91.51.5
Length with tail0.00.21.00.01.0-0.0-0.2-0.7-0.1-0.1-0.20.8-0.10.0-0.5-0.50.10.0-0.20.2-0.30.40.4
Length without tail1.53.34.9-2.01.1-2.2-2.20.1-1.9-1.9-1.4-1.6-2.22.12.02.2-1.8-2.1-2.02.01.8-1.1-1.3
Times rat made contact with spout0.50.62.40.8-1.50.70.7-1.00.30.41.3-1.60.5-0.7-0.10.60.60.30.6-0.6-0.20.40.1
Lifetime Intake0.50.52.0-1.41.1-0.7-0.30.9-0.5-0.4-1.21.1-0.60.60.5-0.1-0.7-0.5-0.80.80.2-0.1-0.2
Liver weight, left0.20.31.11.01.00.3-0.0-0.90.10.2-0.10.90.1-0.3-0.9-1.00.30.10.2-0.2-0.50.40.2
Liver weight, right0.20.31.40.70.50.1-0.10.60.30.4-0.31.20.5-0.2-0.6-1.10.30.50.3-0.3-0.3-0.00.2
Locomotor activity0.40.73.81.9-0.10.90.6-1.40.60.60.9-0.20.7-0.7-1.2-0.80.70.60.8-0.8-0.60.10.3
Locomotor testing distance0.50.82.91.7-0.31.10.8-1.30.70.71.0-0.10.8-1.0-1.1-0.70.90.61.0-1.0-0.70.30.6
Locomotor testing rearing0.71.11.91.0-0.91.11.20.21.11.10.80.71.4-1.2-1.0-1.01.21.21.2-1.2-1.00.31.1
Locomotion in novel chamber0.30.33.11.10.80.4-0.3-1.8-0.0-0.00.2-0.3-0.30.3-0.6-0.2-0.2-0.30.2-0.2-0.20.50.3
Locomotion in novel chamber post-restriction0.50.62.80.30.5-0.8-1.30.8-0.4-0.5-0.6-0.4-0.40.40.40.2-0.5-0.4-0.80.80.7-1.2-1.7
Fecal boli incidents, locomotor time 10.10.10.7-0.30.4-0.2-0.3-0.0-0.10.0-0.20.5-0.20.2-0.1-0.2-0.1-0.00.1-0.1-0.20.10.8
Change in fecal boli incidents, locomotor task0.80.81.5-0.3-0.90.80.50.21.10.90.71.01.1-1.1-0.6-0.71.21.10.9-0.9-1.00.91.0
Time >=10cm from walls, locomotor time 12.52.58.30.2-0.01.41.50.21.61.60.42.61.4-1.5-1.4-1.91.41.31.7-1.7-1.71.82.9
Bouts of movement, locomotor time 12.72.96.21.3-2.11.82.51.22.12.11.21.22.3-1.9-1.1-1.51.71.91.7-1.7-1.40.61.8
Total resting periods, locomotor time 11.82.03.90.6-1.61.31.90.91.71.61.01.31.8-1.5-0.9-1.21.51.61.5-1.5-1.20.72.0
Rest time, locomotor task time 10.30.31.30.2-0.3-0.9-0.90.9-0.3-0.3-0.2-0.8-0.30.50.60.5-0.5-0.3-0.30.30.7-1.2-0.2
Distance moved, locomotor task time 10.91.02.80.60.41.41.1-1.10.90.90.41.40.7-1.0-1.3-1.30.80.70.5-0.5-1.21.70.3
Vertical activity count, locomotor time 10.80.94.61.0-0.31.61.0-2.20.70.71.1-0.30.5-0.8-1.0-0.30.50.40.3-0.3-0.71.5-0.6
Time >=10cm from walls, locomotor time 20.60.62.0-0.4-0.20.70.1-0.20.70.70.41.30.7-0.8-0.7-0.80.80.70.9-0.9-1.01.31.4
Bouts of movement, locomotor time 21.11.13.61.1-1.21.51.91.21.11.00.60.41.7-1.2-0.7-0.91.31.20.7-0.7-0.6-0.60.0
Total resting periods, locomotor time 21.11.23.01.3-1.21.31.71.61.11.00.50.41.7-1.1-0.6-1.01.21.10.7-0.7-0.4-0.90.1
Rest time, locomotor task time 20.30.31.91.4-1.10.00.10.60.60.60.4-0.80.4-0.30.10.20.10.20.1-0.10.3-0.7-0.4
Distance moved, locomotor task time 20.20.31.2-0.51.00.4-0.4-0.6-0.1-0.2-0.21.10.1-0.2-0.6-0.80.30.20.4-0.4-0.60.60.5
Vertical activity count, locomotor time 20.50.66.80.30.40.9-0.0-2.6-0.2-0.30.8-0.6-0.1-0.1-0.80.00.20.10.3-0.3-0.51.0-0.2
Light reinforcement 10.10.21.20.5-0.50.30.2-0.2-0.3-0.20.3-1.10.00.10.20.5-0.3-0.2-0.20.20.3-0.5-0.7
Light reinforcement 20.20.32.10.1-0.30.80.7-1.5-0.0-0.00.8-0.50.2-0.4-0.40.10.20.10.1-0.1-0.40.8-0.1
Bone: marrow area0.30.75.1-0.52.2-0.8-1.1-0.5-0.9-1.0-1.20.9-1.00.7-0.0-0.4-0.5-0.7-0.50.50.2-0.20.1
Bone: maximum diameter1.22.23.81.6-0.51.61.3-1.31.61.61.31.41.3-1.5-2.0-1.81.51.51.4-1.4-1.71.51.1
Bone: maximum force0.10.21.00.81.0-0.0-0.4-0.40.20.2-0.10.9-0.10.0-0.8-1.00.20.20.2-0.2-0.50.10.2
Bone: maximum moment0.20.31.20.70.90.0-0.2-0.30.40.3-0.11.10.1-0.1-0.9-1.10.30.40.3-0.3-0.60.20.4
Mean time between licks in bursts1.62.24.2-1.41.0-0.9-1.0-0.5-1.7-1.7-1.0-1.6-1.71.31.51.9-1.9-2.0-1.81.81.6-0.5-1.7
Mean num. licks in bursts0.10.10.60.1-0.8-0.4-0.4-0.30.00.20.6-0.6-0.00.10.10.30.30.50.2-0.2-0.2-0.10.2
Cd content in liver0.60.72.91.7-1.11.00.9-0.60.90.91.1-0.70.7-0.7-0.7-0.20.60.60.7-0.7-0.40.20.0
Co content in liver2.12.55.02.2-1.52.12.10.21.91.81.40.72.0-1.9-1.5-1.61.41.61.6-1.6-1.30.60.7
Cu content in liver0.40.51.8-0.81.3-0.6-0.51.0-0.7-0.7-1.20.7-0.50.50.4-0.1-0.6-0.6-0.60.60.4-0.5-0.0
Fe content in liver0.80.91.7-1.30.6-1.0-0.9-0.4-1.1-1.1-0.6-0.9-1.30.91.11.3-0.9-1.1-1.11.10.9-0.2-0.6
K content in liver0.40.41.4-0.4-0.70.91.0-0.80.60.50.70.30.6-0.9-0.3-0.10.50.60.5-0.5-0.61.20.7
Mg content in liver0.10.10.6-0.80.40.00.1-0.8-0.2-0.2-0.00.2-0.2-0.10.00.2-0.2-0.2-0.20.2-0.20.70.4
Mn content in liver0.40.52.9-0.40.40.40.70.90.50.5-0.41.70.7-0.4-0.4-1.00.40.50.4-0.4-0.60.60.9
Na content in liver0.10.10.60.3-0.40.60.5-0.80.10.10.5-0.60.1-0.4-0.10.30.00.10.0-0.0-0.00.4-0.3
Rb content in liver0.91.12.00.7-1.10.60.80.41.41.40.81.01.2-1.1-0.8-1.01.11.31.2-1.2-1.10.41.2
Se content in liver0.00.00.1-0.1-0.20.30.3-0.10.20.20.1-0.00.1-0.30.00.10.30.10.1-0.1-0.10.20.2
Sr content in liver1.41.35.70.10.91.00.8-0.60.90.90.12.40.7-0.7-1.5-1.80.71.00.8-0.8-1.51.71.5
Zn content in liver1.82.03.9-1.00.9-1.5-1.31.8-1.4-1.4-1.7-1.0-1.11.21.71.3-1.2-1.7-1.31.31.8-2.0-1.3
Bone: minimum diameter0.20.33.5-0.20.7-0.3-0.6-1.9-0.4-0.40.2-0.3-0.80.3-0.20.3-0.1-0.2-0.10.1-0.10.60.1
Time in familiar zone, hab. session 13.33.14.61.5-1.31.81.8-0.32.12.11.41.72.0-1.9-1.8-1.91.91.81.9-1.9-1.81.51.8
Time in novel zone, hab. session 13.73.64.8-1.51.0-2.0-2.01.0-2.1-2.2-1.6-1.8-1.92.12.02.0-2.2-1.8-2.02.02.1-1.9-1.9
Total zone transitions, hab. session 12.43.311.5-0.93.4-1.8-2.2-0.0-2.1-2.0-2.30.4-2.12.10.80.3-2.2-1.9-2.12.11.4-1.2-1.4
Total locomotion distance, hab. session 13.24.68.1-1.42.8-2.3-2.50.3-2.5-2.5-2.4-0.8-2.42.51.61.4-2.5-2.2-2.32.42.1-1.9-2.0
Locomotion velocity, hab. session 12.53.57.4-1.02.7-1.9-2.2-0.1-2.2-2.2-2.1-0.6-2.22.21.31.1-2.3-1.9-2.12.21.8-1.5-1.8
Time in familiar zone, hab. session 20.50.61.80.2-1.10.81.11.30.90.90.30.61.1-0.9-0.2-0.50.60.60.6-0.6-0.40.00.6
Time in novel zone, hab. session 20.40.41.2-0.30.3-0.7-0.9-1.1-0.6-0.70.1-0.9-0.90.70.30.7-0.5-0.3-0.50.50.30.0-0.6
Total zone transitions, hab. session 20.50.63.9-0.32.0-0.5-0.7-0.1-0.9-1.0-1.20.5-0.70.70.1-0.2-0.8-0.8-0.80.80.6-0.6-0.7
Total locomotion distance, hab. session 21.01.32.9-0.61.7-0.9-1.1-0.1-1.3-1.4-1.3-0.4-1.21.20.70.6-1.4-1.2-1.31.31.1-0.9-1.3
Locomotion velocity, hab. session 21.01.43.3-0.71.8-1.0-1.2-0.1-1.4-1.5-1.4-0.4-1.31.30.80.7-1.4-1.3-1.31.31.2-0.9-1.3
Novel to familiar place preference ratio1.61.73.00.9-0.71.21.3-0.31.31.30.91.31.2-1.5-1.2-1.31.61.51.7-1.7-1.31.11.6
Novelty place preference2.52.54.31.1-1.01.51.6-0.21.71.61.11.61.6-1.9-1.5-1.72.01.82.1-2.1-1.61.21.9
Time in novel zone, NPP test3.33.45.31.5-1.21.81.9-0.22.01.91.41.82.0-2.1-1.8-2.02.22.12.3-2.3-1.91.42.0
Total zone transitions, NPP test1.11.65.6-0.62.4-1.3-1.60.1-1.5-1.5-1.60.0-1.31.50.60.3-1.4-1.3-1.41.41.0-1.1-1.1
Total locomotion distance, NPP test1.01.43.6-0.71.9-1.2-1.40.2-1.4-1.4-1.4-0.2-1.31.40.70.5-1.3-1.1-1.31.31.1-1.2-1.2
Locomotion velocity, NPP test1.52.13.9-1.22.0-1.6-1.80.3-1.8-1.7-1.6-0.5-1.51.71.10.9-1.5-1.4-1.51.51.4-1.3-1.3
Intraocular pressure1.21.79.60.43.1-1.1-1.50.0-1.5-1.4-1.80.5-1.51.30.0-0.5-1.3-1.2-1.11.10.8-1.4-0.7
Delta distance traveled before/after self-admin0.70.82.20.1-1.50.70.9-0.31.11.01.10.10.8-0.9-0.4-0.10.80.91.0-1.0-0.80.81.3
Delta ambulatory time before/after self-admin0.30.31.8-0.3-1.30.40.50.30.60.60.7-0.10.5-0.50.10.20.40.50.7-0.7-0.30.31.0
Parametrial fat weight0.10.20.70.70.10.50.40.20.50.40.00.80.3-0.3-0.6-0.80.00.40.1-0.1-0.40.0-0.0
Pavlov. Cond. lever latency0.70.93.6-0.2-0.8-0.9-0.61.7-0.5-0.5-0.5-1.3-0.30.71.31.1-0.7-0.5-0.50.51.2-1.9-1.0
Pavlov. Cond. magazine entry latency0.30.40.9-0.50.9-0.3-0.3-0.2-0.8-0.8-0.7-0.5-0.80.50.50.6-0.9-1.0-0.80.80.6-0.0-0.5
Pavlov. Cond. change in total contacts0.30.42.40.40.70.70.6-1.60.00.00.30.1-0.0-0.5-0.7-0.40.30.10.4-0.4-0.51.00.6
Pavlov. Cond. index score0.20.21.30.21.10.40.2-1.0-0.1-0.1-0.20.6-0.2-0.2-0.6-0.6-0.0-0.20.0-0.0-0.30.90.3
Pavlov. Cond. latency score0.20.31.30.21.20.50.3-1.0-0.0-0.0-0.10.8-0.1-0.3-0.7-0.70.2-0.10.1-0.1-0.51.00.5
Pavlov. Cond. lever contacts0.50.63.4-0.11.40.50.2-1.8-0.1-0.1-0.01.1-0.3-0.2-0.9-0.70.1-0.1-0.00.0-0.71.70.6
Pavlov. Cond. magazine entry number0.10.10.8-0.1-0.9-0.2-0.10.20.40.40.50.10.30.0-0.00.00.30.60.1-0.1-0.30.00.0
Pavlov. Cond. intertrial magazine entries3.03.66.1-1.9-0.0-2.2-2.01.6-1.9-1.9-1.3-2.0-1.61.92.52.4-1.6-1.8-1.81.82.3-2.3-2.1
Pavlov. Cond. lever-magazine prob. diff.0.20.31.10.40.90.70.5-1.00.10.10.00.70.0-0.4-0.8-0.70.10.00.2-0.2-0.51.00.5
Pavlov. Cond. response bias0.20.21.3-0.11.10.30.2-1.1-0.4-0.4-0.30.1-0.5-0.0-0.2-0.0-0.4-0.5-0.30.30.00.70.1
Pavlov. Cond. lever latency0.10.10.40.6-0.3-0.0-0.10.30.30.30.30.20.4-0.2-0.4-0.50.50.60.5-0.5-0.3-0.40.2
Pavlov. Cond. magazine entry latency0.10.11.0-0.10.5-0.0-0.1-1.0-0.1-0.10.10.0-0.40.2-0.20.0-0.2-0.2-0.20.2-0.30.80.3
Pavlov. Cond. change in total contacts0.40.62.7-0.60.5-0.4-0.5-1.6-0.7-0.60.1-1.0-1.10.70.41.0-0.7-0.8-0.80.80.30.7-0.4
Pavlov. Cond. index score0.20.21.5-0.50.40.0-0.0-1.2-0.2-0.20.1-0.2-0.50.20.10.4-0.4-0.5-0.40.4-0.11.00.1
Pavlov. Cond. latency score0.10.21.1-0.40.30.10.0-1.0-0.1-0.10.1-0.2-0.40.20.00.4-0.3-0.4-0.40.3-0.10.90.2
Pavlov. Cond. lever contacts0.10.20.6-0.80.2-0.1-0.0-0.4-0.3-0.2-0.2-0.2-0.40.20.40.5-0.5-0.6-0.50.50.20.4-0.2
Pavlov. Cond. magazine entry number0.20.22.2-0.0-0.2-0.3-0.11.5-0.1-0.1-0.50.20.30.00.4-0.10.00.10.1-0.00.4-1.1-0.3
Pavlov. Cond. intertrial magazine entries0.20.21.20.40.60.40.20.20.30.3-0.31.10.3-0.4-0.6-0.90.30.30.3-0.3-0.40.00.4
Pavlov. Cond. lever-magazine prob. diff.0.10.21.2-0.60.4-0.0-0.0-1.1-0.3-0.20.0-0.3-0.50.20.10.5-0.3-0.5-0.40.4-0.00.80.1
Pavlov. Cond. response bias0.30.40.9-0.90.6-0.4-0.4-1.0-0.7-0.6-0.3-0.5-0.90.60.50.8-0.7-0.8-0.80.80.40.5-0.3
Time in closed arm before self-admin0.70.82.9-1.4-1.0-0.7-0.61.0-0.6-0.6-0.1-1.5-0.60.51.51.7-0.6-0.7-0.30.31.1-0.7-0.1
Time in closed arm after self-admin0.80.83.00.5-1.70.90.9-0.51.01.01.3-0.71.0-1.0-0.30.20.90.81.1-1.1-0.50.70.7
Time in open arm before self-admin0.60.63.10.21.10.60.6-0.80.40.4-0.01.80.4-0.4-1.1-1.30.30.6-0.10.1-1.11.30.2
Time in open arm after self-admin0.40.42.80.41.7-0.3-0.2-0.0-0.2-0.1-0.71.5-0.30.2-0.8-1.2-0.10.0-0.10.1-0.5-0.00.0
Bone: periosteal estimation0.20.31.70.31.10.1-0.2-1.30.10.0-0.00.9-0.2-0.1-0.8-0.80.30.10.3-0.2-0.60.70.6
Bone: periosteal perimeter0.30.50.90.6-0.40.70.6-0.80.80.70.80.50.7-0.9-0.8-0.71.00.90.8-0.8-0.80.70.5
Bone: post-yield work0.71.04.5-0.31.7-1.0-0.92.1-0.6-0.7-1.71.3-0.30.70.3-0.7-0.5-0.6-0.40.40.6-1.5-0.2
Progressive ratio test 1 active lever presses0.10.21.0-0.30.00.10.40.90.40.4-0.41.00.3-0.2-0.0-0.50.20.30.1-0.1-0.2-0.00.1
Progressive ratio test 1 breakpoint0.10.10.8-0.40.3-0.20.10.90.00.0-0.60.80.00.10.2-0.3-0.2-0.0-0.20.20.1-0.3-0.3
Progressive ratio test 1 inactive lever presses0.10.10.5-0.3-0.3-0.30.10.7-0.10.0-0.2-0.2-0.00.10.40.3-0.1-0.1-0.00.00.3-0.60.1
Progressive ratio test 2 active lever presses0.10.10.9-0.9-0.10.10.50.1-0.0-0.0-0.20.2-0.10.20.40.3-0.2-0.1-0.10.10.10.10.6
Progressive ratio test 2 breakpoint0.10.21.1-1.00.1-0.10.2-0.0-0.3-0.3-0.3-0.0-0.40.40.50.5-0.5-0.3-0.50.50.20.00.2
Progressive ratio test 2 inactive lever presses0.40.51.00.2-0.50.51.00.60.80.90.21.00.8-0.7-0.4-0.80.60.70.8-0.8-0.60.30.9
Incentive Sensitization - Responses1.61.62.5-1.51.3-1.0-1.0-0.1-1.5-1.5-1.2-0.6-1.61.51.21.2-1.6-1.4-1.51.51.2-0.7-0.7
Incentive Sensitization - Breakpoint1.41.42.3-1.41.1-1.0-1.0-0.1-1.4-1.4-1.1-0.8-1.41.41.21.3-1.5-1.4-1.41.41.2-0.8-0.7
Sum of active levers in priming session hrs 5-64.44.36.2-1.62.0-2.3-2.41.1-2.5-2.5-2.2-0.9-2.22.32.01.6-2.2-2.2-2.22.22.1-1.9-2.2
Progressive ratio0.60.71.61.3-0.21.21.20.00.80.80.40.81.1-0.9-1.0-1.20.80.90.7-0.7-0.80.10.0
Food seeking constrained by brief footshock0.70.95.80.02.4-0.0-0.3-1.8-0.6-0.5-0.61.1-0.90.5-0.8-0.7-0.5-0.5-1.01.0-0.40.7-0.7
Seeking ratio, punishment vs. effort1.21.43.2-1.51.6-1.4-1.5-0.9-1.3-1.2-1.0-0.3-1.81.30.81.0-1.2-1.4-1.41.40.70.2-0.3
Retroperitoneal fat weight1.13.75.7-1.01.5-1.7-1.90.6-2.0-2.0-1.7-1.5-2.12.01.81.7-2.3-2.1-2.42.42.2-2.0-2.4
Reaction time number correct0.30.51.4-0.2-0.31.01.1-0.30.60.50.40.80.6-0.9-0.5-0.50.80.40.5-0.5-0.71.20.9
Reaction time mean minus median0.60.72.81.21.2-0.9-1.20.8-0.7-0.6-1.0-0.3-0.51.00.2-0.2-0.7-0.6-0.50.50.8-1.7-1.0
Reaction time mean minus median AUC0.40.51.81.30.8-0.8-1.10.2-0.6-0.5-0.4-0.8-0.40.80.00.0-0.5-0.6-0.40.40.6-1.4-0.9
Reaction time num false alarms0.50.71.8-1.21.3-0.9-0.9-0.2-0.7-0.8-0.90.5-1.21.00.40.3-1.2-0.7-1.21.20.30.3-0.4
Reaction time num false alarms AUC0.60.91.8-1.31.4-1.1-1.10.2-0.8-0.9-1.10.4-1.21.10.70.4-1.2-0.8-1.21.20.5-0.1-0.4
Reaction time trials correct on left0.30.51.4-0.2-0.31.01.1-0.30.60.50.40.80.6-0.9-0.5-0.50.80.40.5-0.5-0.71.20.9
Reaction time trials on left0.30.41.3-0.2-0.20.91.0-0.30.50.50.30.70.5-0.8-0.5-0.40.70.30.4-0.5-0.61.10.8
Reaction time mean0.60.82.30.21.3-1.3-1.5-0.0-1.0-0.9-0.8-0.6-1.01.30.40.4-0.9-0.8-0.70.70.7-1.0-0.7
Reaction time mean AUC0.70.92.50.21.1-1.4-1.60.0-1.0-1.0-0.7-0.9-1.11.40.60.6-1.0-0.9-0.70.70.9-1.1-0.8
Median of all reaction times0.40.51.5-0.21.1-1.1-1.2-0.3-0.8-0.8-0.6-0.4-0.91.00.30.4-0.8-0.7-0.50.50.5-0.4-0.3
Reaction time omissions0.50.61.5-0.01.2-0.7-0.80.5-1.1-1.1-1.0-0.6-0.50.70.60.4-0.5-1.0-0.40.41.0-1.1-0.7
Reaction time false alarm rate0.40.61.3-0.70.8-1.1-1.10.1-0.6-0.7-0.7-0.0-1.01.10.50.4-1.1-0.5-1.01.00.5-0.4-0.6
Reaction time premature initiation rate1.11.42.40.5-1.01.01.21.01.21.30.61.41.5-1.2-0.9-1.31.51.21.6-1.6-1.20.61.4
Reaction time premature initiations1.52.14.10.4-0.81.41.71.01.41.50.62.01.7-1.6-1.2-1.71.71.31.7-1.7-1.51.11.7
Std. dev. reaction times0.71.03.21.11.4-1.2-1.50.7-0.9-0.8-1.1-0.6-0.81.30.30.0-0.9-0.9-0.60.61.0-1.8-1.1
Reaction time trials completed0.30.41.3-0.2-0.20.91.0-0.30.50.50.30.70.5-0.8-0.5-0.40.70.30.4-0.5-0.61.10.8
Reaction time trials AUC0.20.21.0-0.4-0.10.80.9-0.40.30.30.20.50.3-0.6-0.3-0.20.50.10.2-0.2-0.41.00.6
Run reversals in cocaine runway, females4.84.79.52.1-2.02.32.1-3.12.22.22.9-0.11.9-2.2-2.2-1.12.12.22.3-2.3-2.22.21.6
Run reversals in cocaine runway, males1.21.27.31.3-1.40.70.5-2.70.60.62.0-1.60.4-0.6-0.80.40.70.70.5-0.5-0.61.0-0.3
Latency to leave start box in cocaine runway0.20.21.8-0.7-1.3-0.20.3-0.10.30.30.7-0.60.2-0.30.30.60.30.30.1-0.1-0.10.5-0.1
Latency to leave start box in cocaine runway, F0.80.81.8-1.1-0.7-0.9-0.31.3-0.6-0.6-0.4-1.0-0.50.71.31.3-0.7-0.7-0.90.91.0-1.1-1.2
Latency to leave start box in cocaine runway, M0.50.51.7-0.2-0.60.10.0-1.30.50.51.00.10.3-0.6-0.5-0.10.70.80.9-0.9-0.81.31.0
Std. dev. time between licks in bursts1.72.13.5-1.80.8-1.5-1.40.9-1.5-1.6-1.3-1.2-1.31.31.81.6-1.3-1.9-1.41.41.6-1.4-1.2
Total sessions with >9 infusions0.91.02.4-0.81.4-1.0-0.91.3-1.0-0.8-1.50.5-0.91.00.80.1-1.0-0.9-1.11.10.8-1.1-0.9
Short access day 1 total inactive lever presses0.20.20.9-0.4-0.2-0.4-0.60.90.00.1-0.4-0.0-0.10.10.60.3-0.2-0.3-0.50.50.4-0.2-0.8
Short access day 10 total inactive lever presses0.20.21.31.1-0.30.50.10.50.20.20.0-0.80.2-0.10.10.2-0.2-0.20.2-0.20.5-0.70.1
Short access day 1 total infusions1.41.56.1-0.80.6-1.1-1.31.0-1.1-0.9-1.0-0.6-1.01.21.10.9-1.2-1.0-1.71.71.1-1.1-2.5
Short access day 10 total infusions0.50.63.3-1.21.0-0.30.11.7-0.1-0.0-1.31.8-0.20.30.3-0.6-0.4-0.1-0.40.4-0.0-0.20.2
Short access total infusions0.80.92.9-1.71.2-1.0-0.81.3-0.8-0.6-1.51.0-0.90.90.90.2-0.9-0.8-1.11.10.5-0.3-0.7
Short access day 1 locomotion0.60.61.70.7-0.71.31.30.10.71.00.60.51.1-0.9-0.7-0.80.80.90.4-0.4-0.70.4-0.3
Short access day 10 total locomotion0.91.03.10.8-1.71.11.2-1.70.70.91.7-1.50.5-0.8-0.30.60.40.60.3-0.3-0.31.1-0.5
Short access total locomotion0.10.10.60.3-0.00.60.7-0.10.20.50.10.20.3-0.3-0.3-0.30.10.3-0.20.2-0.20.4-0.8
One hour access (0.3 mA shock)1.31.55.1-0.20.10.80.9-0.31.11.10.32.20.9-1.1-1.1-1.51.11.11.3-1.3-1.51.52.3
Compulsive drug intake2.92.98.51.3-0.71.51.3-2.91.41.21.90.31.0-1.4-1.7-0.91.41.22.1-2.1-1.72.42.9
One hour access (shock baseline)0.50.64.0-0.8-0.00.20.51.60.60.7-0.52.00.7-0.6-0.2-1.00.60.70.2-0.2-0.70.30.5
Social response proportion1.21.36.50.0-1.0-0.7-0.60.6-0.9-0.9-0.0-2.6-0.40.71.41.8-0.7-0.8-0.60.61.5-1.8-1.6
Social responses0.30.41.41.2-0.40.60.71.10.60.60.10.40.9-0.6-0.4-0.70.40.50.6-0.6-0.1-0.7-0.1
Social time0.40.63.0-0.71.0-0.4-0.31.7-0.2-0.3-1.31.3-0.20.50.3-0.5-0.7-0.3-0.70.80.3-0.6-0.3
Soleus weight0.72.24.01.8-1.11.71.4-1.51.51.41.70.61.4-1.4-1.9-1.51.42.01.4-1.4-1.61.30.6
Bone: stiffness0.30.52.00.31.3-0.8-1.00.7-0.7-0.7-1.00.2-0.40.60.2-0.3-0.4-0.6-0.30.30.6-1.4-0.5
Tibialis anterior weight1.44.828.63.8-0.12.21.2-5.31.51.42.8-0.10.6-1.2-3.2-1.71.21.51.5-1.5-2.22.60.6
Time to tail flick, vehicle, before self-admin2.22.23.9-1.21.8-1.3-1.01.2-1.7-1.6-2.0-0.2-1.51.61.30.9-1.7-1.7-1.91.91.5-1.4-1.5
Time to tail flick, vehicle, after self-admin0.70.83.8-1.91.6-0.7-0.60.8-0.5-0.5-1.41.7-0.60.40.4-0.3-0.5-0.5-0.50.5-0.00.60.6
Time to tail flick, test, before self-admin0.10.10.90.5-0.00.30.30.40.20.2-0.00.10.3-0.2-0.2-0.30.00.2-0.30.30.0-0.4-0.9
Time to tail flick, test, after self-admin1.71.84.70.2-2.21.01.10.11.71.71.60.51.6-1.5-0.8-0.61.61.71.6-1.6-1.31.01.4
Delta time to tail flick, vehicle, before/after SA0.20.22.2-1.5-0.1-0.1-0.2-0.10.10.1-0.00.6-0.1-0.10.30.20.10.00.1-0.1-0.31.00.7
Delta time to tail flick, test, before/after SA1.41.32.90.6-1.50.80.8-0.11.21.21.20.31.2-1.2-0.7-0.61.41.21.7-1.7-1.00.61.7
Tibia length0.41.26.2-0.3-2.51.11.4-0.61.11.11.7-0.71.0-1.0-0.10.50.80.90.5-0.5-0.71.50.3
Ambulatory time before self-admin0.60.72.41.30.80.90.7-0.10.60.60.01.30.7-0.7-1.2-1.50.70.60.6-0.6-0.80.30.3
Ambulatory time after self-admin0.30.31.10.7-0.10.60.4-0.00.50.40.30.50.6-0.6-0.6-0.60.60.40.8-0.8-0.50.21.0
Bone: tissue strength1.21.22.1-1.0-0.4-1.4-1.30.8-0.8-0.8-0.4-1.3-1.21.21.41.4-1.2-0.8-1.21.21.1-0.9-1.2
Total heroin consumption0.70.81.7-1.00.3-0.8-0.70.1-1.0-1.2-0.6-1.2-0.91.11.21.3-1.0-1.0-0.70.71.1-0.8-0.2
Bone: trabecular number0.20.32.4-1.00.9-0.1-0.10.5-0.0-0.1-0.71.50.10.0-0.2-0.70.1-0.2-0.10.1-0.40.60.6
Bone: trabecular spacing0.40.64.00.0-0.9-0.4-0.4-0.5-0.4-0.50.5-2.0-0.50.40.71.3-0.4-0.5-0.40.40.8-0.7-1.0
Bone: trabecular thickness0.60.84.6-0.90.00.50.80.50.80.8-0.02.10.6-0.6-0.6-1.10.50.60.3-0.3-1.11.41.2
Bone: trabecular tissue density0.50.72.80.6-0.5-0.0-0.00.5-0.4-0.5-0.1-1.7-0.20.30.81.0-0.9-0.7-0.60.61.2-1.4-1.4
Water consumed over 24 hours0.50.62.20.7-1.50.80.8-1.00.50.61.3-1.20.6-0.8-0.20.40.60.40.6-0.6-0.30.50.2
Number of responses in last shaping day0.20.21.91.00.10.20.30.2-0.1-0.0-0.2-0.70.00.20.10.1-0.3-0.3-0.40.40.5-0.8-1.4