Models

A transcriptomic model was trained for each RNA phenotype in each tissue. The table below includes models with cis-heritability P-value < 0.01, which were used for TWAS association testing. Thus, for single phenotype modalities such as expression level, there are 0 or 1 models per gene per tissue, while for multi-phenotype modalities such as isoform ratio, there may be multiple models per gene per tissue.

Tissue Modality Sample size Models
Adipose alternative polyA 411 3710
Adipose alternative TSS 411 3793
Adipose gene expression 411 9929
Adipose isoform ratio 411 4864
Adipose intron excision ratio 411 3179
Adipose mRNA stability 411 4409
BLA alternative polyA 189 2209
BLA alternative TSS 189 2009
BLA gene expression 189 7126
BLA isoform ratio 189 3028
BLA intron excision ratio 189 3392
BLA mRNA stability 189 2377
Brain alternative polyA 342 3732
Brain alternative TSS 342 4086
Brain gene expression 342 10716
Brain isoform ratio 342 5595
Brain intron excision ratio 342 6066
Brain mRNA stability 342 5392
Eye alternative polyA 53 269
Eye alternative TSS 53 430
Eye gene expression 53 1272
Eye isoform ratio 53 563
Eye intron excision ratio 53 910
Eye mRNA stability 53 367
IC alternative polyA 148 1856
IC alternative TSS 148 1782
IC gene expression 148 6594
IC isoform ratio 148 2611
IC intron excision ratio 148 3555
IC mRNA stability 148 1566
IL alternative polyA 83 1160
IL alternative TSS 83 755
IL gene expression 83 4449
IL isoform ratio 83 1283
IL intron excision ratio 83 1210
IL mRNA stability 83 1359
LHb alternative polyA 82 1101
LHb alternative TSS 82 692
LHb gene expression 82 3922
LHb isoform ratio 82 1258
LHb intron excision ratio 82 1239
LHb mRNA stability 82 1252
Liver alternative polyA 411 2574
Liver alternative TSS 411 2892
Liver gene expression 411 8200
Liver isoform ratio 411 3616
Liver intron excision ratio 411 4847
Liver mRNA stability 411 3023
NAcc alternative polyA 570 3530
NAcc alternative TSS 570 3722
NAcc gene expression 570 10176
NAcc isoform ratio 570 5231
NAcc intron excision ratio 570 6441
NAcc mRNA stability 570 3687
OFC alternative polyA 82 1177
OFC alternative TSS 82 809
OFC gene expression 82 4539
OFC isoform ratio 82 1419
OFC intron excision ratio 82 1295
OFC mRNA stability 82 1330
PL alternative polyA 404 3294
PL alternative TSS 404 3333
PL gene expression 404 9804
PL isoform ratio 404 4724
PL intron excision ratio 404 5582
PL mRNA stability 404 3781
pVTA alternative polyA 293 2571
pVTA alternative TSS 293 2485
pVTA gene expression 293 7859
pVTA isoform ratio 293 3582
pVTA intron excision ratio 293 5034
pVTA mRNA stability 293 2348
RMTg alternative polyA 92 623
RMTg alternative TSS 92 581
RMTg gene expression 92 2103
RMTg isoform ratio 92 773
RMTg intron excision ratio 92 883
RMTg mRNA stability 92 621