Models

A transcriptomic model was trained for each RNA phenotype in each tissue. The table below includes models with cis-heritability P-value < 0.01, which were used for TWAS association testing. Thus, for single phenotype modalities such as expression level, there are 0 or 1 models per gene per tissue, while for multi-phenotype modalities such as isoform ratio, there may be multiple models per gene per tissue.

Tissue Modality Sample size Models
Adipose alternative polyA 411 3663
Adipose alternative TSS 411 3373
Adipose gene expression 411 9297
Adipose isoform ratio 411 4631
Adipose intron excision ratio 411 3180
Adipose mRNA stability 411 4436
BLA alternative polyA 191 2217
BLA alternative TSS 191 1888
BLA gene expression 191 6760
BLA isoform ratio 191 3046
BLA intron excision ratio 191 3324
BLA mRNA stability 191 2434
Brain alternative polyA 341 3697
Brain alternative TSS 341 4026
Brain gene expression 341 10088
Brain isoform ratio 341 5623
Brain intron excision ratio 341 6005
Brain mRNA stability 341 5403
Eye alternative polyA 53 297
Eye alternative TSS 53 400
Eye gene expression 53 1230
Eye isoform ratio 53 580
Eye intron excision ratio 53 919
Eye mRNA stability 53 362
IL alternative polyA 83 1103
IL alternative TSS 83 653
IL gene expression 83 4172
IL isoform ratio 83 1256
IL intron excision ratio 83 1121
IL mRNA stability 83 1384
LHb alternative polyA 82 1118
LHb alternative TSS 82 604
LHb gene expression 82 3691
LHb isoform ratio 82 1275
LHb intron excision ratio 82 1173
LHb mRNA stability 82 1269
Liver alternative polyA 411 2632
Liver alternative TSS 411 2673
Liver gene expression 411 7908
Liver isoform ratio 411 3749
Liver intron excision ratio 411 4840
Liver mRNA stability 411 3066
NAcc alternative polyA 430 3112
NAcc alternative TSS 430 2807
NAcc gene expression 430 8564
NAcc isoform ratio 430 4286
NAcc intron excision ratio 430 4949
NAcc mRNA stability 430 3275
OFC alternative polyA 82 1126
OFC alternative TSS 82 713
OFC gene expression 82 4196
OFC isoform ratio 82 1352
OFC intron excision ratio 82 1173
OFC mRNA stability 82 1351
PL alternative polyA 407 3296
PL alternative TSS 407 3307
PL gene expression 407 9284
PL isoform ratio 407 4753
PL intron excision ratio 407 5439
PL mRNA stability 407 3880
pVTA alternative polyA 153 1674
pVTA alternative TSS 153 1336
pVTA gene expression 153 5294
pVTA isoform ratio 153 2250
pVTA intron excision ratio 153 3006
pVTA mRNA stability 153 1461
RMTg alternative polyA 93 586
RMTg alternative TSS 93 475
RMTg gene expression 93 1833
RMTg isoform ratio 93 661
RMTg intron excision ratio 93 814
RMTg mRNA stability 93 620