Hub : Genes

Rpl37a-ps11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Rpl37a-ps11 0.1 0.07 1.1e-12 0.09 0.09 0.09 0.09 8.7e-10 4.8e-10 7.3e-10 1.2e-09
2 RMTg gene expression Rpl37a-ps11 0.12 0.1 2.7e-03 0.1 0.07 0.1 0.08 1.7e-03 5.9e-03 1.5e-03 4.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.50.91.0-1.00.9
Area under the delay curve0.00.00.00.20.1
BMI with tail6.924.225.05.0-4.8
BMI without tail1.78.98.93.0-3.0
Body weight4.720.721.84.7-4.4
Weight adjusted by age2.46.97.02.6-2.6
Bone surface0.00.10.10.2-0.2
Bone volume0.00.00.0-0.1-0.0
Breakpoint value in progressive ratio session0.71.21.31.0-1.1
Number of licking bursts0.82.53.0-1.71.4
Context. condit. distance diff. score1.01.21.2-1.11.1
Locomotion velocity, session 10.80.91.30.7-1.1
Locomotion distance, session 10.40.50.6-0.80.6
Locomotion velocity, session 20.10.10.20.2-0.4
Locomotion distance, session 20.00.10.10.1-0.3
Locomotion velocity, session 30.10.10.1-0.30.3
Locomotion distance, session 32.22.62.8-1.71.5
Stereotopy head waving bouts, day 30.80.91.21.1-0.8
Stereotopy head waving duration, day 31.01.31.51.2-1.0
Locomotion velocity, session 71.82.02.5-1.61.2
Locomotion distance, session 71.72.12.6-1.61.3
Stereotopy head waving bouts, day 71.71.92.31.5-1.2
Stereotopy head waving duration, day 71.41.72.11.5-1.1
Locomotion velocity, session 80.10.20.30.1-0.5
Locomotion distance, session 80.81.21.4-1.21.0
Degree of sensitization distance0.10.10.1-0.30.2
Degree of sensitization stereotypy0.91.01.21.1-0.9
Conditioned locomotion0.10.10.1-0.40.1
Cocaine response after cond. corrected2.84.24.62.0-2.1
Cocaine response after cond. not corrected1.72.42.61.5-1.6
Cocaine response before conditioning1.21.41.7-1.11.3
Saline control response0.00.00.10.20.2
Bone: connectivity density1.01.61.6-1.31.3
Bone: cortical apparent density1.11.71.8-1.31.3
Bone: cortical area0.10.20.2-0.50.3
Bone: cortical porosity1.01.11.1-1.11.0
Bone: cortical porosity1.51.61.7-1.31.2
Bone: cortical thickness1.93.13.5-1.91.6
Bone: cortical thickness0.81.01.1-1.10.9
Bone: cortical tissue density1.01.61.7-1.21.3
Condit. Reinf. active minus inactive responses0.00.00.1-0.10.2
Condit. Reinf. active-inactive response ratio0.60.60.7-0.70.8
Condit. Reinf. active responses0.30.30.50.7-0.5
Condit. Reinf. inactive responses0.91.21.41.2-1.0
Incentive salience index mean0.00.00.0-0.10.2
Condit. Reinf. lever presses0.10.10.1-0.30.3
Condit. Reinf. active minus inactive responses2.33.53.71.9-1.8
Condit. Reinf. active-inactive response ratio0.71.01.21.1-0.9
Condit. Reinf. active responses1.31.81.91.4-1.3
Condit. Reinf. inactive responses0.00.00.0-0.20.1
Condit. Reinf. lever presses0.71.11.1-1.01.1
Condit. Reinf. lever reinforcers received0.81.11.21.1-1.0
Conditioned reinforcement - actives0.10.50.70.8-0.6
Conditioned reinforcement - inactives0.00.00.0-0.10.1
Conditioned locomotion0.10.10.3-0.10.5
Patch foraging indifference point 0 sec0.10.20.30.6-0.3
Patch foraging indifference point AUC0.00.10.1-0.0-0.3
Delay disc. indifference point, 0s delay0.30.30.5-0.40.7
Delay disc. indifference point, 16s delay0.00.10.1-0.10.3
Delay disc. indifference point, 2s delay0.00.00.00.10.1
Delay disc. indifference point, 24s delay0.20.30.5-0.40.7
Delay disc. indifference point, 4s delay0.10.10.1-0.10.4
Delay disc. indifference point, 8s delay0.00.10.10.3-0.2
Indifference point function ln k0.10.40.60.8-0.4
Indifference point function log k0.10.40.60.8-0.4
Patch foraging total patch changes 0 sec0.10.30.40.6-0.4
Patch foraging total patch changes 12 sec0.00.00.0-0.10.2
Patch foraging total patch changes 18 sec0.10.10.10.4-0.3
Patch foraging total patch changes 24 sec0.00.00.00.1-0.2
Patch foraging total patch changes 6 sec0.30.50.60.7-0.8
Patch foraging time to switch 0 sec0.51.92.1-1.31.4
Patch foraging water rate 0 sec0.93.33.51.9-1.8
Patch foraging water rate 12 sec1.45.65.72.3-2.4
Patch foraging water rate 18 sec0.10.30.50.7-0.4
Patch foraging water rate 24 sec0.30.40.50.6-0.7
Patch foraging water rate 6 sec1.31.82.01.4-1.3
Seeking ratio, delayed vs. immediate footshock0.50.81.00.8-1.0
Distance traveled before self-admin0.10.10.20.5-0.3
Distance traveled after self-admin0.81.31.61.3-1.0
Extensor digitorum longus weight8.533.834.05.8-5.8
Bone: elastic displacement0.40.50.60.7-0.8
Bone: elastic work0.00.00.00.0-0.2
Bone: endosteal estimation1.84.54.62.2-2.1
Bone: endosteal perimeter2.76.76.92.6-2.6
Epididymis fat weight0.00.00.00.10.1
Delta time in closed arm before/after self-admin1.31.21.6-1.30.9
Delta time in open arm before/after self-admin0.20.20.2-0.40.4
Diff in mean of infusions in LGA sessions0.71.31.61.2-1.0
Delay discount exponential model param0.00.10.1-0.30.0
Extinction: sum of active levers before priming0.30.50.50.7-0.7
Active lever presses in extinction session 60.60.60.70.8-0.7
Bone: final force0.10.20.30.3-0.6
Bone: final moment0.00.00.0-0.1-0.1
Food consumed during 24 hour testing period0.61.11.41.2-0.9
Glucose0.81.21.31.1-1.1
Heart weight1.22.02.51.6-1.2
Delay discount hyperbolic model param0.00.00.0-0.2-0.1
Intermittent access intake day 1-15 change0.10.60.7-0.80.8
Intermittent access intake escalation0.10.50.5-0.70.7
Intermittent access intake escalation 20.00.00.00.2-0.1
Intermitt. access day 1 inactive lever presses0.44.65.3-2.02.3
Intermitt. access day 15 inactive lever presses0.00.20.30.6-0.2
Intermitt. access escalation Index0.10.40.50.7-0.5
Intermittent access day 1 total infusions0.20.70.8-0.90.8
Intermittent access day 15 total infusions0.61.41.5-1.21.1
Intermittent access terminal intake (last 3 days)0.20.30.4-0.60.5
Intermittent access total infusions0.20.20.2-0.40.4
Intermittent access day 1 locomotion1.52.83.1-1.61.8
Intermittent access day 15 total locomotion0.62.42.9-1.31.7
Intermittent access total locomotion0.10.10.10.10.4
Intermittent access standard deviation0.00.20.3-0.50.5
Left kidney weight1.29.59.83.1-3.0
Right kidney weight1.812.413.03.6-3.4
Cocaine induced anxiety0.10.10.2-0.20.5
Post-drug Anxiety2.52.83.2-1.61.8
Baseline Anxiety0.71.11.2-1.11.0
Tail length0.00.00.00.1-0.2
Length with tail0.62.62.71.6-1.6
Length without tail2.010.711.43.4-3.2
Times rat made contact with spout0.30.40.4-0.50.7
Lifetime Intake0.10.10.2-0.40.2
Liver weight, left3.35.65.62.4-2.4
Liver weight, right0.81.51.71.1-1.3
Locomotor activity6.510.111.03.3-3.0
Locomotor testing distance2.86.97.52.7-2.5
Locomotor testing rearing1.03.73.92.0-1.9
Locomotion in novel chamber0.30.40.6-0.50.8
Locomotion in novel chamber post-restriction0.30.80.9-0.81.0
Fecal boli incidents, locomotor time 10.00.00.0-0.10.2
Change in fecal boli incidents, locomotor task0.00.00.10.0-0.3
Time >=10cm from walls, locomotor time 10.10.10.10.4-0.3
Bouts of movement, locomotor time 10.00.10.10.2-0.3
Total resting periods, locomotor time 10.10.10.20.2-0.4
Rest time, locomotor task time 10.00.00.1-0.1-0.3
Distance moved, locomotor task time 10.10.20.3-0.30.6
Vertical activity count, locomotor time 10.00.30.5-0.30.7
Time >=10cm from walls, locomotor time 20.00.00.0-0.10.1
Bouts of movement, locomotor time 20.72.22.31.4-1.5
Total resting periods, locomotor time 20.62.52.81.5-1.7
Rest time, locomotor task time 20.10.10.2-0.50.3
Distance moved, locomotor task time 20.10.10.1-0.20.3
Vertical activity count, locomotor time 20.30.60.9-0.51.0
Light reinforcement 11.04.65.02.2-2.0
Light reinforcement 20.10.30.4-0.60.5
Bone: marrow area1.84.54.62.1-2.1
Bone: maximum diameter1.63.23.31.7-1.8
Bone: maximum force0.10.20.30.4-0.6
Bone: maximum moment0.00.00.0-0.0-0.2
Mean time between licks in bursts0.10.40.5-0.60.7
Mean num. licks in bursts0.41.21.61.3-0.9
Cd content in liver1.31.41.5-1.21.2
Co content in liver1.21.41.5-1.21.2
Cu content in liver0.00.00.0-0.2-0.0
Fe content in liver0.10.20.20.5-0.4
K content in liver1.71.61.61.3-1.3
Mg content in liver1.51.61.71.3-1.3
Mn content in liver0.00.00.0-0.20.2
Na content in liver7.18.08.22.8-2.9
Rb content in liver0.60.70.70.8-0.8
Se content in liver0.00.00.1-0.10.2
Sr content in liver0.00.00.0-0.20.2
Zn content in liver0.00.00.00.1-0.1
Bone: minimum diameter0.10.10.2-0.20.4
Time in familiar zone, hab. session 10.00.00.1-0.20.1
Time in novel zone, hab. session 10.00.00.0-0.10.1
Total zone transitions, hab. session 10.71.01.1-1.11.0
Total locomotion distance, hab. session 10.10.20.2-0.40.4
Locomotion velocity, hab. session 10.00.00.0-0.10.2
Time in familiar zone, hab. session 20.00.10.1-0.30.1
Time in novel zone, hab. session 20.00.00.1-0.00.2
Total zone transitions, hab. session 20.20.20.30.3-0.6
Total locomotion distance, hab. session 20.60.70.80.8-0.9
Locomotion velocity, hab. session 20.20.30.40.5-0.6
Novel to familiar place preference ratio1.11.41.51.2-1.2
Novelty place preference1.11.41.51.2-1.2
Time in novel zone, NPP test1.41.71.81.3-1.3
Total zone transitions, NPP test0.10.10.10.4-0.3
Total locomotion distance, NPP test0.40.60.70.8-0.7
Locomotion velocity, NPP test0.10.20.20.5-0.4
Intraocular pressure0.00.00.10.0-0.3
Delta distance traveled before/after self-admin0.70.80.80.9-0.8
Delta ambulatory time before/after self-admin0.10.20.30.5-0.3
Parametrial fat weight0.92.23.1-1.81.1
Pavlov. Cond. lever latency0.10.10.1-0.30.3
Pavlov. Cond. magazine entry latency0.81.01.1-1.10.9
Pavlov. Cond. change in total contacts0.00.00.00.10.1
Pavlov. Cond. index score0.50.70.7-0.90.8
Pavlov. Cond. latency score0.20.30.3-0.50.5
Pavlov. Cond. lever contacts0.00.00.0-0.10.0
Pavlov. Cond. magazine entry number1.01.31.41.2-1.1
Pavlov. Cond. intertrial magazine entries0.10.10.10.3-0.3
Pavlov. Cond. lever-magazine prob. diff.0.30.40.4-0.60.6
Pavlov. Cond. response bias0.40.50.5-0.70.7
Pavlov. Cond. lever latency0.40.60.60.8-0.8
Pavlov. Cond. magazine entry latency3.34.74.9-2.12.2
Pavlov. Cond. change in total contacts0.30.81.0-0.81.0
Pavlov. Cond. index score1.01.61.6-1.21.3
Pavlov. Cond. latency score0.61.01.0-1.01.0
Pavlov. Cond. lever contacts0.40.50.6-0.70.8
Pavlov. Cond. magazine entry number3.85.05.02.2-2.2
Pavlov. Cond. intertrial magazine entries0.61.21.31.1-1.1
Pavlov. Cond. lever-magazine prob. diff.1.21.81.8-1.31.3
Pavlov. Cond. response bias1.72.42.5-1.51.6
Time in closed arm before self-admin0.00.10.10.10.3
Time in closed arm after self-admin0.40.50.5-0.70.7
Time in open arm before self-admin0.50.60.60.7-0.8
Time in open arm after self-admin0.20.30.30.5-0.5
Bone: periosteal estimation0.81.81.91.3-1.4
Bone: periosteal perimeter1.42.72.91.6-1.7
Bone: post-yield work0.00.10.10.3-0.2
Progressive ratio test 1 active lever presses0.00.10.1-0.30.1
Progressive ratio test 1 breakpoint0.10.10.2-0.40.2
Progressive ratio test 1 inactive lever presses1.33.53.8-1.91.8
Progressive ratio test 2 active lever presses0.20.20.30.5-0.5
Progressive ratio test 2 breakpoint0.20.20.20.5-0.5
Progressive ratio test 2 inactive lever presses0.10.20.3-0.30.5
Incentive Sensitization - Responses0.10.30.50.7-0.5
Incentive Sensitization - Breakpoint0.10.20.30.6-0.4
Sum of active levers in priming session hrs 5-60.20.20.20.4-0.4
Progressive ratio0.20.60.7-0.70.8
Food seeking constrained by brief footshock0.20.20.20.5-0.4
Seeking ratio, punishment vs. effort1.73.73.81.9-1.9
Retroperitoneal fat weight0.10.40.4-0.70.6
Reaction time number correct0.82.72.91.5-1.7
Reaction time mean minus median0.00.10.1-0.30.2
Reaction time mean minus median AUC0.10.60.8-0.90.6
Reaction time num false alarms0.50.91.1-1.00.9
Reaction time num false alarms AUC0.20.40.5-0.70.6
Reaction time trials correct on left0.82.72.91.5-1.7
Reaction time trials on left0.82.83.21.6-1.8
Reaction time mean1.63.54.0-2.01.7
Reaction time mean AUC1.02.42.8-1.71.4
Median of all reaction times3.96.16.8-2.62.3
Reaction time omissions0.20.30.50.4-0.7
Reaction time false alarm rate1.72.32.3-1.51.5
Reaction time premature initiation rate1.62.52.91.5-1.7
Reaction time premature initiations1.54.55.21.9-2.3
Std. dev. reaction times0.31.01.4-1.20.8
Reaction time trials completed0.82.83.21.6-1.8
Reaction time trials AUC0.72.42.71.4-1.6
Run reversals in cocaine runway, females0.00.00.1-0.20.0
Run reversals in cocaine runway, males0.00.00.00.1-0.1
Latency to leave start box in cocaine runway2.02.83.51.9-1.5
Latency to leave start box in cocaine runway, F0.60.71.11.0-0.6
Latency to leave start box in cocaine runway, M6.56.26.22.5-2.5
Std. dev. time between licks in bursts0.20.30.30.6-0.6
Total sessions with >9 infusions0.10.20.4-0.60.1
Short access day 1 total inactive lever presses0.40.80.9-0.90.9
Short access day 10 total inactive lever presses0.31.72.4-1.01.5
Short access day 1 total infusions0.00.10.1-0.3-0.0
Short access day 10 total infusions0.71.21.6-1.30.9
Short access total infusions0.40.50.7-0.90.5
Short access day 1 locomotion0.00.00.1-0.3-0.0
Short access day 10 total locomotion0.20.81.1-0.81.0
Short access total locomotion0.40.60.6-0.80.7
One hour access (0.3 mA shock)1.01.11.31.0-1.1
Compulsive drug intake1.01.51.81.1-1.3
One hour access (shock baseline)0.00.10.1-0.30.2
Social response proportion0.30.40.7-0.20.8
Social responses0.00.00.10.10.2
Social time0.00.00.10.30.0
Soleus weight17.049.950.07.1-7.1
Bone: stiffness0.50.91.01.0-0.9
Tibialis anterior weight13.948.049.06.9-7.0
Time to tail flick, vehicle, before self-admin0.20.30.3-0.60.5
Time to tail flick, vehicle, after self-admin0.40.91.2-0.71.1
Time to tail flick, test, before self-admin1.92.22.5-1.61.4
Time to tail flick, test, after self-admin2.22.43.3-1.21.8
Delta time to tail flick, vehicle, before/after SA0.60.60.8-0.60.9
Delta time to tail flick, test, before/after SA0.10.20.30.6-0.1
Tibia length0.10.20.4-0.30.6
Ambulatory time before self-admin0.00.00.00.0-0.1
Ambulatory time after self-admin0.30.50.50.7-0.6
Bone: tissue strength1.31.41.4-1.21.1
Total heroin consumption1.92.32.41.5-1.5
Bone: trabecular number1.42.52.7-1.61.6
Bone: trabecular spacing0.00.10.10.3-0.2
Bone: trabecular thickness0.50.70.8-0.90.7
Bone: trabecular tissue density3.66.36.72.4-2.6
Water consumed over 24 hours0.10.30.3-0.50.5
Number of responses in last shaping day0.00.00.00.10.1