Stoml2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL intron excision ratio chr5_62054530_62055222 0.02 0.02 5.5e-03 0.02 0.02 0.03 0.02 2.3e-03 3.2e-03 7.0e-04 4.1e-03
2 Adipose gene expression Stoml2 0.03 0.02 3.0e-03 0.01 0.01 0 0.01 1.2e-02 1.8e-02 1.9e-01 2.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density2.54.57.52.7-1.2
Area under the delay curve0.10.20.3-0.20.6
BMI with tail2.48.311.43.4-2.3
BMI without tail1.68.610.73.3-2.5
Body weight2.310.216.12.1-4.0
Weight adjusted by age0.10.40.7-0.8-0.3
Bone surface1.01.92.41.6-1.2
Bone volume1.12.13.31.8-1.0
Breakpoint value in progressive ratio session0.61.12.1-1.40.2
Number of licking bursts1.44.17.31.0-2.7
Context. condit. distance diff. score0.10.10.2-0.10.4
Locomotion velocity, session 11.21.31.6-1.3-1.0
Locomotion distance, session 10.30.40.7-0.1-0.9
Locomotion velocity, session 22.63.14.02.0-1.5
Locomotion distance, session 22.13.04.51.2-2.1
Locomotion velocity, session 30.40.40.6-0.8-0.5
Locomotion distance, session 32.12.43.21.2-1.8
Stereotopy head waving bouts, day 34.14.89.7-3.10.1
Stereotopy head waving duration, day 34.35.310.3-3.20.5
Locomotion velocity, session 70.00.00.1-0.10.2
Locomotion distance, session 70.60.70.80.9-0.8
Stereotopy head waving bouts, day 71.01.21.3-1.1-1.1
Stereotopy head waving duration, day 70.91.11.5-1.2-0.8
Locomotion velocity, session 80.20.30.5-0.7-0.3
Locomotion distance, session 80.20.30.60.1-0.8
Degree of sensitization distance0.90.91.1-0.91.0
Degree of sensitization stereotypy0.60.71.30.1-1.1
Conditioned locomotion1.01.22.4-1.5-0.2
Cocaine response after cond. corrected2.13.25.5-2.30.9
Cocaine response after cond. not corrected2.23.15.7-2.40.8
Cocaine response before conditioning0.50.60.90.6-0.9
Saline control response1.62.22.8-1.7-1.3
Bone: connectivity density2.13.36.22.5-0.6
Bone: cortical apparent density0.50.81.61.30.1
Bone: cortical area2.94.85.82.4-1.9
Bone: cortical porosity0.30.30.3-0.60.6
Bone: cortical porosity0.40.40.8-0.90.1
Bone: cortical thickness1.93.15.32.3-0.9
Bone: cortical thickness0.40.50.70.80.6
Bone: cortical tissue density0.40.61.21.10.2
Condit. Reinf. active minus inactive responses0.30.40.50.5-0.7
Condit. Reinf. active-inactive response ratio0.40.50.90.01.0
Condit. Reinf. active responses2.12.73.21.5-1.8
Condit. Reinf. inactive responses3.74.85.92.4-1.9
Incentive salience index mean2.93.75.81.3-2.4
Condit. Reinf. lever presses6.59.716.81.6-4.1
Condit. Reinf. active minus inactive responses0.91.42.01.4-1.0
Condit. Reinf. active-inactive response ratio0.61.01.91.4-0.3
Condit. Reinf. active responses2.73.84.12.0-1.9
Condit. Reinf. inactive responses2.13.13.71.6-1.9
Condit. Reinf. lever presses3.14.55.72.4-1.8
Condit. Reinf. lever reinforcers received3.04.24.22.0-2.0
Conditioned reinforcement - actives2.811.021.7-4.7-0.6
Conditioned reinforcement - inactives2.36.312.6-3.6-0.0
Conditioned locomotion1.82.74.9-2.2-0.7
Patch foraging indifference point 0 sec0.61.72.8-1.7-0.8
Patch foraging indifference point AUC5.012.012.43.5-3.4
Delay disc. indifference point, 0s delay2.62.95.1-2.30.9
Delay disc. indifference point, 16s delay0.91.22.0-1.40.7
Delay disc. indifference point, 2s delay0.10.20.3-0.6-0.1
Delay disc. indifference point, 24s delay0.40.61.01.00.4
Delay disc. indifference point, 4s delay0.20.20.30.60.2
Delay disc. indifference point, 8s delay0.71.22.31.5-0.2
Indifference point function ln k2.06.08.4-2.91.9
Indifference point function log k2.06.08.4-2.91.9
Patch foraging total patch changes 0 sec0.61.72.0-1.4-1.2
Patch foraging total patch changes 12 sec1.72.22.81.3-1.7
Patch foraging total patch changes 18 sec0.51.21.31.1-1.1
Patch foraging total patch changes 24 sec0.51.93.20.7-1.8
Patch foraging total patch changes 6 sec1.62.64.70.7-2.2
Patch foraging time to switch 0 sec0.93.44.0-1.72.0
Patch foraging water rate 0 sec0.51.82.80.9-1.7
Patch foraging water rate 12 sec0.00.10.2-0.4-0.2
Patch foraging water rate 18 sec0.20.40.50.7-0.5
Patch foraging water rate 24 sec0.10.10.20.30.5
Patch foraging water rate 6 sec0.71.11.7-0.7-1.3
Seeking ratio, delayed vs. immediate footshock2.33.34.51.5-2.1
Distance traveled before self-admin2.45.38.2-1.5-2.9
Distance traveled after self-admin1.93.43.6-1.9-1.8
Extensor digitorum longus weight3.313.221.72.2-4.7
Bone: elastic displacement3.54.48.60.52.9
Bone: elastic work2.73.64.41.62.1
Bone: endosteal estimation0.71.63.2-0.3-1.8
Bone: endosteal perimeter0.71.73.30.1-1.8
Epididymis fat weight0.52.64.22.1-1.0
Delta time in closed arm before/after self-admin1.00.91.81.4-0.2
Delta time in open arm before/after self-admin0.80.91.7-1.30.3
Diff in mean of infusions in LGA sessions0.10.20.20.50.4
Delay discount exponential model param0.10.10.2-0.1-0.5
Extinction: sum of active levers before priming3.95.98.9-3.01.7
Active lever presses in extinction session 60.20.20.30.20.6
Bone: final force1.83.03.31.6-1.8
Bone: final moment1.72.83.01.7-1.6
Food consumed during 24 hour testing period0.40.91.70.2-1.3
Glucose3.45.36.52.5-2.0
Heart weight2.74.48.22.9-0.8
Delay discount hyperbolic model param0.10.10.1-0.3-0.3
Intermittent access intake day 1-15 change0.10.50.7-0.6-0.8
Intermittent access intake escalation0.10.50.5-0.6-0.7
Intermittent access intake escalation 20.50.80.9-0.8-1.0
Intermitt. access day 1 inactive lever presses0.23.14.62.1-1.3
Intermitt. access day 15 inactive lever presses0.20.91.6-1.3-0.4
Intermitt. access escalation Index0.20.71.01.0-0.6
Intermittent access day 1 total infusions1.54.57.9-2.81.0
Intermittent access day 15 total infusions1.02.54.9-2.2-0.2
Intermittent access terminal intake (last 3 days)4.88.416.3-4.0-0.7
Intermittent access total infusions3.94.68.9-3.0-0.6
Intermittent access day 1 locomotion1.12.02.9-1.71.1
Intermittent access day 15 total locomotion0.31.21.3-1.21.1
Intermittent access total locomotion3.74.57.4-2.71.2
Intermittent access standard deviation0.20.91.0-0.9-1.0
Left kidney weight0.11.22.2-0.3-1.5
Right kidney weight0.32.23.61.9-0.9
Cocaine induced anxiety1.33.67.1-2.7-0.2
Post-drug Anxiety1.41.61.8-1.2-1.3
Baseline Anxiety1.32.33.92.0-0.8
Tail length0.84.27.40.9-2.7
Length with tail0.94.17.7-0.8-2.8
Length without tail0.52.75.1-2.3-0.6
Times rat made contact with spout0.20.20.40.2-0.6
Lifetime Intake6.68.215.9-4.0-0.8
Liver weight, left0.00.00.00.00.2
Liver weight, right2.23.86.4-2.51.1
Locomotor activity0.00.00.1-0.3-0.2
Locomotor testing distance0.51.22.4-1.6-0.0
Locomotor testing rearing0.52.02.3-1.3-1.5
Locomotion in novel chamber0.20.30.40.40.6
Locomotion in novel chamber post-restriction0.72.13.21.8-1.0
Fecal boli incidents, locomotor time 10.51.42.40.61.5
Change in fecal boli incidents, locomotor task0.80.91.40.6-1.2
Time >=10cm from walls, locomotor time 10.10.10.1-0.3-0.3
Bouts of movement, locomotor time 12.43.13.8-1.91.6
Total resting periods, locomotor time 12.93.43.8-1.71.9
Rest time, locomotor task time 11.21.93.70.21.9
Distance moved, locomotor task time 10.92.55.00.1-2.2
Vertical activity count, locomotor time 10.32.03.9-0.5-2.0
Time >=10cm from walls, locomotor time 20.30.81.61.3-0.3
Bouts of movement, locomotor time 20.20.70.9-0.7-0.9
Total resting periods, locomotor time 20.20.81.3-1.2-0.5
Rest time, locomotor task time 21.52.53.1-1.81.4
Distance moved, locomotor task time 21.62.13.21.8-1.0
Vertical activity count, locomotor time 21.02.32.91.7-1.3
Light reinforcement 10.83.54.3-1.6-2.1
Light reinforcement 21.94.47.3-2.7-1.2
Bone: marrow area0.71.63.20.0-1.8
Bone: maximum diameter2.03.94.81.8-2.2
Bone: maximum force2.65.16.61.9-2.6
Bone: maximum moment2.34.45.01.9-2.2
Mean time between licks in bursts0.00.20.4-0.00.6
Mean num. licks in bursts0.82.03.9-0.32.0
Cd content in liver0.80.91.7-0.2-1.3
Co content in liver0.70.81.4-1.20.4
Cu content in liver1.31.52.3-0.91.5
Fe content in liver1.01.32.3-1.50.6
K content in liver0.40.40.7-0.80.3
Mg content in liver0.50.61.0-0.31.0
Mn content in liver0.40.50.80.4-0.9
Na content in liver1.31.41.5-1.21.2
Rb content in liver4.55.25.6-2.22.4
Se content in liver1.31.62.70.6-1.7
Sr content in liver0.40.40.50.7-0.5
Zn content in liver0.91.02.11.4-0.1
Bone: minimum diameter0.10.20.20.50.3
Time in familiar zone, hab. session 11.51.62.31.50.9
Time in novel zone, hab. session 13.03.46.0-2.50.8
Total zone transitions, hab. session 10.60.81.51.2-0.1
Total locomotion distance, hab. session 11.72.44.52.1-0.5
Locomotion velocity, hab. session 13.04.26.52.6-1.4
Time in familiar zone, hab. session 21.11.31.51.21.0
Time in novel zone, hab. session 25.15.610.4-3.20.9
Total zone transitions, hab. session 20.40.61.10.3-1.0
Total locomotion distance, hab. session 20.81.01.20.9-1.1
Locomotion velocity, hab. session 21.41.82.01.4-1.3
Novel to familiar place preference ratio4.55.88.6-2.91.7
Novelty place preference5.36.89.3-3.12.1
Time in novel zone, NPP test6.88.311.3-3.42.3
Total zone transitions, NPP test0.71.01.60.7-1.2
Total locomotion distance, NPP test1.62.33.41.1-1.8
Locomotion velocity, NPP test2.33.34.31.5-2.1
Intraocular pressure1.72.84.61.1-2.1
Delta distance traveled before/after self-admin0.20.20.3-0.60.2
Delta ambulatory time before/after self-admin0.50.91.2-1.10.8
Parametrial fat weight0.40.91.91.40.1
Pavlov. Cond. lever latency4.25.310.1-0.73.2
Pavlov. Cond. magazine entry latency1.11.42.01.4-0.9
Pavlov. Cond. change in total contacts1.71.83.60.2-1.9
Pavlov. Cond. index score2.43.04.71.2-2.2
Pavlov. Cond. latency score2.02.54.30.8-2.1
Pavlov. Cond. lever contacts3.84.68.60.8-2.9
Pavlov. Cond. magazine entry number1.51.92.9-1.71.0
Pavlov. Cond. intertrial magazine entries0.10.10.20.3-0.4
Pavlov. Cond. lever-magazine prob. diff.2.63.24.41.5-2.1
Pavlov. Cond. response bias3.64.45.91.7-2.4
Pavlov. Cond. lever latency2.63.74.6-2.11.6
Pavlov. Cond. magazine entry latency0.10.20.2-0.30.5
Pavlov. Cond. change in total contacts1.94.78.83.0-0.7
Pavlov. Cond. index score0.81.32.51.6-0.3
Pavlov. Cond. latency score0.91.42.61.6-0.4
Pavlov. Cond. lever contacts2.03.04.12.0-1.4
Pavlov. Cond. magazine entry number0.60.81.5-1.20.1
Pavlov. Cond. intertrial magazine entries0.10.30.40.4-0.6
Pavlov. Cond. lever-magazine prob. diff.0.91.42.81.7-0.3
Pavlov. Cond. response bias1.31.83.01.7-0.8
Time in closed arm before self-admin0.71.21.91.40.8
Time in closed arm after self-admin0.60.71.11.00.6
Time in open arm before self-admin1.11.31.9-0.8-1.4
Time in open arm after self-admin0.70.81.2-0.6-1.1
Bone: periosteal estimation1.22.84.41.1-2.1
Bone: periosteal perimeter0.40.81.5-0.3-1.2
Bone: post-yield work1.32.34.50.4-2.1
Progressive ratio test 1 active lever presses8.014.228.3-5.3-0.1
Progressive ratio test 1 breakpoint7.613.026.0-5.1-0.2
Progressive ratio test 1 inactive lever presses1.23.04.3-2.1-1.3
Progressive ratio test 2 active lever presses9.012.725.5-5.00.0
Progressive ratio test 2 breakpoint9.912.725.4-5.00.1
Progressive ratio test 2 inactive lever presses0.93.05.5-2.3-0.7
Incentive Sensitization - Responses3.810.420.7-4.6-0.3
Incentive Sensitization - Breakpoint4.19.218.4-4.3-0.2
Sum of active levers in priming session hrs 5-62.52.32.5-1.51.6
Progressive ratio0.20.50.90.90.2
Food seeking constrained by brief footshock5.06.212.3-0.3-3.5
Seeking ratio, punishment vs. effort1.22.64.1-1.1-2.0
Retroperitoneal fat weight0.31.21.41.01.2
Reaction time number correct0.20.60.91.0-0.5
Reaction time mean minus median0.96.012.03.50.2
Reaction time mean minus median AUC0.63.97.82.8-0.3
Reaction time num false alarms0.10.20.3-0.50.2
Reaction time num false alarms AUC0.10.20.3-0.4-0.5
Reaction time trials correct on left0.20.60.91.0-0.5
Reaction time trials on left0.20.50.91.0-0.4
Reaction time mean1.53.33.31.81.8
Reaction time mean AUC1.33.24.01.62.0
Median of all reaction times1.72.75.20.42.3
Reaction time omissions1.01.73.2-0.31.8
Reaction time false alarm rate0.50.71.4-1.20.4
Reaction time premature initiation rate1.42.13.9-0.52.0
Reaction time premature initiations0.41.12.30.11.5
Std. dev. reaction times1.34.37.82.80.9
Reaction time trials completed0.20.50.91.0-0.4
Reaction time trials AUC0.20.71.21.1-0.4
Run reversals in cocaine runway, females5.46.011.93.40.4
Run reversals in cocaine runway, males0.10.10.1-0.40.3
Latency to leave start box in cocaine runway0.40.50.80.5-0.9
Latency to leave start box in cocaine runway, F0.00.00.0-0.20.2
Latency to leave start box in cocaine runway, M1.61.53.1-0.2-1.7
Std. dev. time between licks in bursts0.20.30.5-0.30.7
Total sessions with >9 infusions10.913.526.1-5.1-1.0
Short access day 1 total inactive lever presses1.53.03.3-1.8-1.6
Short access day 10 total inactive lever presses0.21.61.91.4-1.2
Short access day 1 total infusions6.012.022.5-4.7-1.2
Short access day 10 total infusions1.62.75.0-2.2-0.6
Short access total infusions9.112.925.3-5.0-0.7
Short access day 1 locomotion0.81.32.2-1.50.6
Short access day 10 total locomotion0.10.61.0-0.51.0
Short access total locomotion0.20.30.6-0.80.2
One hour access (0.3 mA shock)2.63.05.9-2.4-0.4
Compulsive drug intake1.11.63.21.8-0.0
One hour access (shock baseline)1.74.58.8-3.0-0.5
Social response proportion1.41.72.90.81.7
Social responses0.91.21.41.2-1.0
Social time0.00.00.00.0-0.0
Soleus weight0.10.40.4-0.6-0.6
Bone: stiffness3.25.78.11.8-2.9
Tibialis anterior weight6.120.933.62.9-5.8
Time to tail flick, vehicle, before self-admin2.22.73.82.01.3
Time to tail flick, vehicle, after self-admin0.00.00.00.1-0.1
Time to tail flick, test, before self-admin0.40.40.6-0.5-0.8
Time to tail flick, test, after self-admin11.512.123.24.8-1.0
Delta time to tail flick, vehicle, before/after SA1.01.01.3-1.1-0.9
Delta time to tail flick, test, before/after SA3.34.18.02.80.4
Tibia length0.61.62.7-1.7-0.7
Ambulatory time before self-admin1.54.66.9-1.5-2.6
Ambulatory time after self-admin1.93.04.4-2.1-1.3
Bone: tissue strength0.40.40.50.7-0.6
Total heroin consumption2.63.15.7-2.40.7
Bone: trabecular number2.14.07.02.6-1.0
Bone: trabecular spacing0.10.20.3-0.6-0.1
Bone: trabecular thickness0.20.20.40.30.6
Bone: trabecular tissue density1.83.26.00.6-2.4
Water consumed over 24 hours0.40.71.4-0.0-1.2
Number of responses in last shaping day4.25.510.5-3.2-0.7