Stoml2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL intron excision ratio chr5_62054530_62055222 0.02 0.02 5.5e-03 0.02 0.02 0.03 0.02 2.3e-03 3.2e-03 7.0e-04 4.0e-03
2 Adipose gene expression Stoml2 0.03 0.02 3.0e-03 0.01 0.01 0 0.01 1.2e-02 1.8e-02 1.9e-01 2.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density2.64.57.5-2.71.2
Area under the delay curve0.20.20.30.2-0.6
BMI with tail2.48.311.4-3.42.3
BMI without tail2.88.610.7-3.32.5
Body weight2.310.216.1-2.14.0
Weight adjusted by age0.20.40.70.80.3
Bone surface1.01.92.4-1.61.2
Bone volume1.22.13.3-1.81.0
Breakpoint value in progressive ratio session0.91.12.11.4-0.2
Number of licking bursts2.54.17.3-1.02.7
Context. condit. distance diff. score0.10.10.20.1-0.4
Locomotion velocity, session 11.21.31.61.31.0
Locomotion distance, session 10.30.40.70.10.9
Locomotion velocity, session 22.73.14.0-2.01.5
Locomotion distance, session 22.13.04.5-1.22.1
Locomotion velocity, session 30.40.40.60.80.5
Locomotion distance, session 32.22.43.2-1.21.8
Stereotopy head waving bouts, day 34.14.89.73.1-0.1
Stereotopy head waving duration, day 34.45.310.33.2-0.5
Locomotion velocity, session 70.00.00.10.1-0.2
Locomotion distance, session 70.60.70.8-0.90.8
Stereotopy head waving bouts, day 71.11.21.31.11.1
Stereotopy head waving duration, day 70.91.11.51.20.8
Locomotion velocity, session 80.20.30.50.70.3
Locomotion distance, session 80.20.30.6-0.10.8
Degree of sensitization distance0.90.91.10.9-1.0
Degree of sensitization stereotypy0.60.71.3-0.11.1
Conditioned locomotion1.01.22.41.50.2
Cocaine response after cond. corrected2.63.25.52.3-0.9
Cocaine response after cond. not corrected2.73.15.72.4-0.8
Cocaine response before conditioning0.50.60.9-0.60.9
Saline control response1.72.22.81.71.3
Bone: connectivity density2.13.36.2-2.50.6
Bone: cortical apparent density0.60.81.6-1.3-0.1
Bone: cortical area3.14.85.8-2.41.9
Bone: cortical porosity0.30.30.30.6-0.6
Bone: cortical porosity0.40.40.80.9-0.1
Bone: cortical thickness1.93.15.3-2.30.9
Bone: cortical thickness0.40.50.7-0.8-0.6
Bone: cortical tissue density0.50.61.2-1.1-0.2
Condit. Reinf. active minus inactive responses0.30.40.5-0.50.7
Condit. Reinf. active-inactive response ratio0.40.50.9-0.0-1.0
Condit. Reinf. active responses2.22.73.2-1.51.8
Condit. Reinf. inactive responses3.94.85.9-2.41.9
Incentive salience index mean3.03.75.8-1.32.4
Condit. Reinf. lever presses6.99.716.8-1.64.1
Condit. Reinf. active minus inactive responses1.11.42.0-1.41.0
Condit. Reinf. active-inactive response ratio0.91.01.9-1.40.3
Condit. Reinf. active responses2.83.84.1-2.01.9
Condit. Reinf. inactive responses2.43.13.7-1.61.9
Condit. Reinf. lever presses3.24.55.7-2.41.8
Condit. Reinf. lever reinforcers received3.04.24.2-2.02.0
Conditioned reinforcement - actives6.511.021.74.70.6
Conditioned reinforcement - inactives4.36.312.63.60.0
Conditioned locomotion2.12.74.92.20.7
Patch foraging indifference point 0 sec0.91.72.81.70.8
Patch foraging indifference point AUC8.312.012.4-3.53.4
Delay disc. indifference point, 0s delay2.72.95.12.3-0.9
Delay disc. indifference point, 16s delay1.11.22.01.4-0.7
Delay disc. indifference point, 2s delay0.10.20.30.60.1
Delay disc. indifference point, 24s delay0.50.61.0-1.0-0.4
Delay disc. indifference point, 4s delay0.20.20.3-0.6-0.2
Delay disc. indifference point, 8s delay1.01.22.3-1.50.2
Indifference point function ln k3.56.08.42.9-1.9
Indifference point function log k3.56.08.42.9-1.9
Patch foraging total patch changes 0 sec0.91.72.01.41.2
Patch foraging total patch changes 12 sec1.72.22.8-1.31.7
Patch foraging total patch changes 18 sec0.81.21.3-1.11.1
Patch foraging total patch changes 24 sec1.11.93.2-0.71.8
Patch foraging total patch changes 6 sec1.72.64.7-0.72.2
Patch foraging time to switch 0 sec1.73.44.01.7-2.0
Patch foraging water rate 0 sec0.91.82.8-0.91.7
Patch foraging water rate 12 sec0.10.10.20.40.2
Patch foraging water rate 18 sec0.30.40.5-0.70.5
Patch foraging water rate 24 sec0.10.10.2-0.3-0.5
Patch foraging water rate 6 sec0.71.11.70.71.3
Seeking ratio, delayed vs. immediate footshock2.73.34.5-1.52.1
Distance traveled before self-admin4.05.38.21.52.9
Distance traveled after self-admin2.73.43.61.91.8
Extensor digitorum longus weight3.413.221.7-2.24.7
Bone: elastic displacement3.84.48.6-0.5-2.9
Bone: elastic work2.73.64.4-1.6-2.1
Bone: endosteal estimation0.71.63.20.31.8
Bone: endosteal perimeter0.81.73.3-0.11.8
Epididymis fat weight0.82.64.2-2.11.0
Delta time in closed arm before/after self-admin1.00.91.8-1.40.2
Delta time in open arm before/after self-admin0.90.91.71.3-0.3
Diff in mean of infusions in LGA sessions0.10.20.2-0.5-0.4
Delay discount exponential model param0.10.10.20.10.5
Extinction: sum of active levers before priming5.45.98.93.0-1.7
Active lever presses in extinction session 60.20.20.3-0.2-0.6
Bone: final force1.93.03.3-1.61.8
Bone: final moment1.72.83.0-1.71.6
Food consumed during 24 hour testing period0.60.91.7-0.21.3
Glucose3.45.36.5-2.52.0
Heart weight2.84.48.2-2.90.8
Delay discount hyperbolic model param0.10.10.10.30.3
Intermittent access intake day 1-15 change0.20.50.70.60.8
Intermittent access intake escalation0.20.50.50.60.7
Intermittent access intake escalation 20.70.80.90.81.0
Intermitt. access day 1 inactive lever presses0.83.14.6-2.11.3
Intermitt. access day 15 inactive lever presses0.40.91.61.30.4
Intermitt. access escalation Index0.50.71.0-1.00.6
Intermittent access day 1 total infusions2.84.57.92.8-1.0
Intermittent access day 15 total infusions1.72.54.92.20.2
Intermittent access terminal intake (last 3 days)6.48.416.34.00.7
Intermittent access total infusions3.94.68.93.00.6
Intermittent access day 1 locomotion1.62.02.91.7-1.1
Intermittent access day 15 total locomotion0.71.21.31.2-1.1
Intermittent access total locomotion3.74.57.42.7-1.2
Intermittent access standard deviation0.40.91.00.91.0
Left kidney weight0.21.22.20.31.5
Right kidney weight0.52.23.6-1.90.9
Cocaine induced anxiety2.53.67.12.70.2
Post-drug Anxiety1.51.61.81.21.3
Baseline Anxiety1.92.33.9-2.00.8
Tail length1.14.27.4-0.92.7
Length with tail1.04.17.70.82.8
Length without tail0.92.75.12.30.6
Times rat made contact with spout0.20.20.4-0.20.6
Lifetime Intake6.88.215.94.00.8
Liver weight, left0.00.00.0-0.0-0.2
Liver weight, right2.23.86.42.5-1.1
Locomotor activity0.00.00.10.30.2
Locomotor testing distance0.71.22.41.60.0
Locomotor testing rearing1.02.02.31.31.5
Locomotion in novel chamber0.20.30.4-0.4-0.6
Locomotion in novel chamber post-restriction1.32.13.2-1.81.0
Fecal boli incidents, locomotor time 11.01.42.4-0.6-1.5
Change in fecal boli incidents, locomotor task0.90.91.4-0.61.2
Time >=10cm from walls, locomotor time 10.10.10.10.30.3
Bouts of movement, locomotor time 12.73.13.81.9-1.6
Total resting periods, locomotor time 13.03.43.81.7-1.9
Rest time, locomotor task time 11.51.93.7-0.2-1.9
Distance moved, locomotor task time 11.72.55.0-0.12.2
Vertical activity count, locomotor time 10.82.03.90.52.0
Time >=10cm from walls, locomotor time 20.60.81.6-1.30.3
Bouts of movement, locomotor time 20.40.70.90.70.9
Total resting periods, locomotor time 20.50.81.31.20.5
Rest time, locomotor task time 22.02.53.11.8-1.4
Distance moved, locomotor task time 21.82.13.2-1.81.0
Vertical activity count, locomotor time 21.72.32.9-1.71.3
Light reinforcement 11.43.54.31.62.1
Light reinforcement 22.84.47.32.71.2
Bone: marrow area0.71.63.2-0.01.8
Bone: maximum diameter2.13.94.8-1.82.2
Bone: maximum force2.95.16.6-1.92.6
Bone: maximum moment2.54.45.0-1.92.2
Mean time between licks in bursts0.10.20.40.0-0.6
Mean num. licks in bursts1.32.03.90.3-2.0
Cd content in liver0.80.91.70.21.3
Co content in liver0.70.81.41.2-0.4
Cu content in liver1.31.52.30.9-1.5
Fe content in liver1.11.32.31.5-0.6
K content in liver0.40.40.70.8-0.3
Mg content in liver0.60.61.00.3-1.0
Mn content in liver0.40.50.8-0.40.9
Na content in liver1.31.41.51.2-1.2
Rb content in liver4.55.25.62.2-2.4
Se content in liver1.31.62.7-0.61.7
Sr content in liver0.40.40.5-0.70.5
Zn content in liver0.91.02.1-1.40.1
Bone: minimum diameter0.10.20.2-0.5-0.3
Time in familiar zone, hab. session 11.71.62.3-1.5-0.9
Time in novel zone, hab. session 13.43.46.02.5-0.8
Total zone transitions, hab. session 10.60.81.5-1.20.1
Total locomotion distance, hab. session 11.72.44.5-2.10.5
Locomotion velocity, hab. session 13.04.26.5-2.61.4
Time in familiar zone, hab. session 21.21.31.5-1.2-1.0
Time in novel zone, hab. session 25.55.610.43.2-0.9
Total zone transitions, hab. session 20.40.61.1-0.31.0
Total locomotion distance, hab. session 20.81.01.2-0.91.1
Locomotion velocity, hab. session 21.41.82.0-1.41.3
Novel to familiar place preference ratio5.35.88.62.9-1.7
Novelty place preference6.46.89.33.1-2.1
Time in novel zone, NPP test7.88.311.33.4-2.3
Total zone transitions, NPP test0.71.01.6-0.71.2
Total locomotion distance, NPP test1.72.33.4-1.11.8
Locomotion velocity, NPP test2.33.34.3-1.52.1
Intraocular pressure2.02.84.6-1.12.1
Delta distance traveled before/after self-admin0.20.20.30.6-0.2
Delta ambulatory time before/after self-admin0.80.91.21.1-0.8
Parametrial fat weight0.40.91.9-1.4-0.1
Pavlov. Cond. lever latency4.25.310.10.7-3.2
Pavlov. Cond. magazine entry latency1.11.42.0-1.40.9
Pavlov. Cond. change in total contacts1.71.83.6-0.21.9
Pavlov. Cond. index score2.43.04.7-1.22.2
Pavlov. Cond. latency score2.02.54.3-0.82.1
Pavlov. Cond. lever contacts3.94.68.6-0.82.9
Pavlov. Cond. magazine entry number1.51.92.91.7-1.0
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.30.4
Pavlov. Cond. lever-magazine prob. diff.2.63.24.4-1.52.1
Pavlov. Cond. response bias3.64.45.9-1.72.4
Pavlov. Cond. lever latency2.73.74.62.1-1.6
Pavlov. Cond. magazine entry latency0.10.20.20.3-0.5
Pavlov. Cond. change in total contacts2.94.78.8-3.00.7
Pavlov. Cond. index score1.01.32.5-1.60.3
Pavlov. Cond. latency score1.01.42.6-1.60.4
Pavlov. Cond. lever contacts2.23.04.1-2.01.4
Pavlov. Cond. magazine entry number0.60.81.51.2-0.1
Pavlov. Cond. intertrial magazine entries0.20.30.4-0.40.6
Pavlov. Cond. lever-magazine prob. diff.1.11.42.8-1.70.3
Pavlov. Cond. response bias1.41.83.0-1.70.8
Time in closed arm before self-admin1.01.21.9-1.4-0.8
Time in closed arm after self-admin0.70.71.1-1.0-0.6
Time in open arm before self-admin1.21.31.90.81.4
Time in open arm after self-admin0.70.81.20.61.1
Bone: periosteal estimation1.32.84.4-1.12.1
Bone: periosteal perimeter0.40.81.50.31.2
Bone: post-yield work1.62.34.5-0.42.1
Progressive ratio test 1 active lever presses11.514.228.35.30.1
Progressive ratio test 1 breakpoint10.713.026.05.10.2
Progressive ratio test 1 inactive lever presses2.13.04.32.11.3
Progressive ratio test 2 active lever presses10.912.725.55.0-0.0
Progressive ratio test 2 breakpoint11.112.725.45.0-0.1
Progressive ratio test 2 inactive lever presses1.83.05.52.30.7
Incentive Sensitization - Responses7.410.420.74.60.3
Incentive Sensitization - Breakpoint7.19.218.44.30.2
Sum of active levers in priming session hrs 5-62.52.32.51.5-1.6
Progressive ratio0.30.50.9-0.9-0.2
Food seeking constrained by brief footshock5.16.212.30.33.5
Seeking ratio, punishment vs. effort1.82.64.11.12.0
Retroperitoneal fat weight0.31.21.4-1.0-1.2
Reaction time number correct0.30.60.9-1.00.5
Reaction time mean minus median2.46.012.0-3.5-0.2
Reaction time mean minus median AUC1.63.97.8-2.80.3
Reaction time num false alarms0.10.20.30.5-0.2
Reaction time num false alarms AUC0.10.20.30.40.5
Reaction time trials correct on left0.30.60.9-1.00.5
Reaction time trials on left0.30.50.9-1.00.4
Reaction time mean2.13.33.3-1.8-1.8
Reaction time mean AUC2.03.24.0-1.6-2.0
Median of all reaction times1.92.75.2-0.4-2.3
Reaction time omissions1.11.73.20.3-1.8
Reaction time false alarm rate0.50.71.41.2-0.4
Reaction time premature initiation rate1.52.13.90.5-2.0
Reaction time premature initiations0.61.12.3-0.1-1.5
Std. dev. reaction times2.34.37.8-2.8-0.9
Reaction time trials completed0.30.50.9-1.00.4
Reaction time trials AUC0.40.71.2-1.10.4
Run reversals in cocaine runway, females6.06.011.9-3.4-0.4
Run reversals in cocaine runway, males0.10.10.10.4-0.3
Latency to leave start box in cocaine runway0.40.50.8-0.50.9
Latency to leave start box in cocaine runway, F0.00.00.00.2-0.2
Latency to leave start box in cocaine runway, M1.71.53.10.21.7
Std. dev. time between licks in bursts0.20.30.50.3-0.7
Total sessions with >9 infusions11.213.526.15.11.0
Short access day 1 total inactive lever presses2.33.03.31.81.6
Short access day 10 total inactive lever presses0.71.61.9-1.41.2
Short access day 1 total infusions9.012.022.54.71.2
Short access day 10 total infusions2.12.75.02.20.6
Short access total infusions10.112.925.35.00.7
Short access day 1 locomotion1.01.32.21.5-0.6
Short access day 10 total locomotion0.30.61.00.5-1.0
Short access total locomotion0.30.30.60.8-0.2
One hour access (0.3 mA shock)2.63.05.92.40.4
Compulsive drug intake1.31.63.2-1.80.0
One hour access (shock baseline)3.04.58.83.00.5
Social response proportion1.51.72.9-0.8-1.7
Social responses0.91.21.4-1.21.0
Social time0.00.00.0-0.00.0
Soleus weight0.10.40.40.60.6
Bone: stiffness3.55.78.1-1.82.9
Tibialis anterior weight6.220.933.6-2.95.8
Time to tail flick, vehicle, before self-admin2.62.73.8-2.0-1.3
Time to tail flick, vehicle, after self-admin0.00.00.0-0.10.1
Time to tail flick, test, before self-admin0.40.40.60.50.8
Time to tail flick, test, after self-admin11.712.123.2-4.81.0
Delta time to tail flick, vehicle, before/after SA1.11.01.31.10.9
Delta time to tail flick, test, before/after SA4.04.18.0-2.8-0.4
Tibia length0.61.62.71.70.7
Ambulatory time before self-admin3.14.66.91.52.6
Ambulatory time after self-admin2.63.04.42.11.3
Bone: tissue strength0.40.40.5-0.70.6
Total heroin consumption2.63.15.72.4-0.7
Bone: trabecular number2.44.07.0-2.61.0
Bone: trabecular spacing0.10.20.30.60.1
Bone: trabecular thickness0.20.20.4-0.3-0.6
Bone: trabecular tissue density2.13.26.0-0.62.4
Water consumed over 24 hours0.50.71.40.01.2
Number of responses in last shaping day5.05.510.53.20.7