Stoml2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Stoml2 0.02 0.02 4.5e-03 0.01 0.01 0 0.01 2.8e-02 3.5e-02 1.2e-01 5.1e-02
2 PL intron excision ratio chr5_57258715_57259407 0.02 0.02 6.2e-03 0.02 0.01 0 0.01 6.7e-03 4.3e-02 8.8e-02 2.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.22.02.5-1.21.6
Area under the delay curve0.50.60.90.5-1.0
BMI with tail2.68.310.1-2.63.2
BMI without tail5.912.312.3-3.53.5
Body weight3.614.915.4-3.93.8
Weight adjusted by age0.10.10.1-0.2-0.3
Bone surface0.71.21.3-1.21.0
Bone volume0.71.21.3-1.11.1
Breakpoint value in progressive ratio session0.80.81.60.3-1.3
Number of licking bursts6.27.37.3-2.72.7
Context. condit. distance diff. score0.10.10.20.5-0.3
Locomotion velocity, session 10.70.71.3-1.1-0.4
Locomotion distance, session 10.30.40.7-0.9-0.0
Locomotion velocity, session 22.52.93.3-1.61.8
Locomotion distance, session 22.33.24.3-2.11.4
Locomotion velocity, session 30.10.10.2-0.4-0.3
Locomotion distance, session 32.22.43.1-1.71.3
Stereotopy head waving bouts, day 30.20.30.60.0-0.8
Stereotopy head waving duration, day 30.40.50.80.5-0.9
Locomotion velocity, session 70.10.10.10.3-0.2
Locomotion distance, session 70.20.30.5-0.70.4
Stereotopy head waving bouts, day 72.22.52.8-1.71.5
Stereotopy head waving duration, day 70.60.70.9-0.90.7
Locomotion velocity, session 80.10.10.1-0.4-0.2
Locomotion distance, session 80.20.30.5-0.70.1
Degree of sensitization distance1.01.01.11.1-1.0
Degree of sensitization stereotypy1.31.51.5-1.21.2
Conditioned locomotion0.10.20.3-0.1-0.6
Cocaine response after cond. corrected2.12.33.51.1-1.9
Cocaine response after cond. not corrected1.61.82.90.8-1.7
Cocaine response before conditioning1.11.31.3-1.11.1
Saline control response1.01.32.1-1.40.7
Bone: connectivity density0.50.81.2-0.71.1
Bone: cortical apparent density0.10.20.20.40.4
Bone: cortical area2.63.94.8-1.72.2
Bone: cortical porosity0.50.60.60.8-0.7
Bone: cortical porosity0.00.00.00.1-0.1
Bone: cortical thickness1.01.62.6-0.81.6
Bone: cortical thickness0.10.10.30.50.0
Bone: cortical tissue density0.10.10.20.40.3
Condit. Reinf. active minus inactive responses0.60.60.8-0.70.9
Condit. Reinf. active-inactive response ratio0.50.60.90.9-0.5
Condit. Reinf. active responses3.13.84.3-1.82.1
Condit. Reinf. inactive responses3.94.65.5-1.92.3
Incentive salience index mean4.75.76.0-2.42.3
Condit. Reinf. lever presses10.914.517.1-4.13.4
Condit. Reinf. active minus inactive responses0.70.91.0-0.91.0
Condit. Reinf. active-inactive response ratio0.10.10.2-0.20.4
Condit. Reinf. active responses2.53.53.5-1.91.9
Condit. Reinf. inactive responses3.74.54.9-2.02.2
Condit. Reinf. lever presses2.53.44.5-1.52.1
Condit. Reinf. lever reinforcers received2.94.04.0-2.02.0
Conditioned reinforcement - actives0.70.71.3-1.10.2
Conditioned reinforcement - inactives0.20.20.3-0.6-0.3
Conditioned locomotion0.70.81.5-1.20.3
Patch foraging indifference point 0 sec0.40.61.1-1.0-0.4
Patch foraging indifference point AUC8.09.29.7-3.13.0
Delay disc. indifference point, 0s delay1.51.72.31.0-1.5
Delay disc. indifference point, 16s delay1.31.42.30.6-1.5
Delay disc. indifference point, 2s delay0.00.00.10.00.2
Delay disc. indifference point, 24s delay0.10.10.20.4-0.3
Delay disc. indifference point, 4s delay0.10.10.10.3-0.3
Delay disc. indifference point, 8s delay0.00.00.0-0.20.1
Indifference point function ln k2.63.73.91.9-2.0
Indifference point function log k2.63.73.91.9-2.0
Patch foraging total patch changes 0 sec0.61.01.9-1.40.0
Patch foraging total patch changes 12 sec2.22.83.1-1.81.6
Patch foraging total patch changes 18 sec0.70.91.2-1.10.8
Patch foraging total patch changes 24 sec2.02.43.2-1.81.3
Patch foraging total patch changes 6 sec2.33.45.0-2.21.3
Patch foraging time to switch 0 sec2.43.64.32.1-1.7
Patch foraging water rate 0 sec1.42.22.9-1.71.2
Patch foraging water rate 12 sec0.00.00.0-0.2-0.0
Patch foraging water rate 18 sec0.20.30.5-0.40.7
Patch foraging water rate 24 sec0.10.20.20.40.4
Patch foraging water rate 6 sec0.91.31.7-1.30.9
Seeking ratio, delayed vs. immediate footshock3.74.24.3-2.12.0
Distance traveled before self-admin5.35.68.0-2.81.8
Distance traveled after self-admin1.11.21.4-1.21.1
Extensor digitorum longus weight5.019.821.2-4.64.3
Bone: elastic displacement4.85.57.12.7-2.0
Bone: elastic work1.82.34.12.0-0.7
Bone: endosteal estimation1.02.23.0-1.71.2
Bone: endosteal perimeter1.02.13.0-1.71.0
Epididymis fat weight0.81.82.0-1.41.3
Delta time in closed arm before/after self-admin2.32.33.7-0.91.9
Delta time in open arm before/after self-admin0.40.30.70.2-0.8
Diff in mean of infusions in LGA sessions0.10.10.20.40.2
Delay discount exponential model param0.40.40.7-0.40.8
Extinction: sum of active levers before priming2.02.02.21.3-1.5
Active lever presses in extinction session 61.01.01.11.1-0.9
Bone: final force1.52.42.6-1.51.6
Bone: final moment1.11.82.2-1.21.5
Food consumed during 24 hour testing period1.11.31.7-1.31.0
Glucose1.21.82.0-1.41.3
Heart weight0.81.11.3-1.10.9
Delay discount hyperbolic model param0.30.40.6-0.40.8
Intermittent access intake day 1-15 change1.01.01.5-0.71.2
Intermittent access intake escalation1.41.42.0-0.91.4
Intermittent access intake escalation 21.91.92.9-0.91.7
Intermitt. access day 1 inactive lever presses0.80.90.9-0.91.0
Intermitt. access day 15 inactive lever presses0.10.10.2-0.4-0.2
Intermitt. access escalation Index0.90.81.1-1.00.7
Intermittent access day 1 total infusions0.70.81.50.3-1.2
Intermittent access day 15 total infusions0.40.50.7-0.80.6
Intermittent access terminal intake (last 3 days)1.01.11.8-1.30.7
Intermittent access total infusions0.80.91.4-1.20.6
Intermittent access day 1 locomotion1.51.52.10.9-1.5
Intermittent access day 15 total locomotion0.80.91.30.7-1.1
Intermittent access total locomotion0.50.60.70.7-0.8
Intermittent access standard deviation0.70.80.8-0.90.8
Left kidney weight0.41.21.7-1.30.8
Right kidney weight0.00.10.1-0.3-0.1
Cocaine induced anxiety0.91.01.30.8-1.2
Post-drug Anxiety0.50.60.8-0.90.6
Baseline Anxiety1.51.62.5-0.81.6
Tail length2.67.78.9-3.02.6
Length with tail0.82.94.2-2.01.3
Length without tail0.40.81.20.7-1.1
Times rat made contact with spout0.60.70.8-0.70.9
Lifetime Intake1.11.22.4-1.50.2
Liver weight, left0.71.11.2-1.11.0
Liver weight, right0.00.10.10.0-0.4
Locomotor activity0.10.10.2-0.40.1
Locomotor testing distance0.20.30.3-0.5-0.5
Locomotor testing rearing1.32.03.3-1.80.8
Locomotion in novel chamber0.10.10.10.40.2
Locomotion in novel chamber post-restriction2.02.43.5-1.11.9
Fecal boli incidents, locomotor time 11.11.21.91.4-0.7
Change in fecal boli incidents, locomotor task1.31.32.2-1.50.6
Time >=10cm from walls, locomotor time 10.10.10.1-0.3-0.3
Bouts of movement, locomotor time 11.92.02.21.5-1.4
Total resting periods, locomotor time 12.52.73.51.9-1.4
Rest time, locomotor task time 11.92.13.92.0-0.5
Distance moved, locomotor task time 12.32.54.2-2.10.9
Vertical activity count, locomotor time 11.51.52.9-1.70.4
Time >=10cm from walls, locomotor time 20.10.10.1-0.30.2
Bouts of movement, locomotor time 20.70.70.9-1.00.7
Total resting periods, locomotor time 20.20.20.4-0.60.4
Rest time, locomotor task time 21.21.41.81.3-1.0
Distance moved, locomotor task time 20.70.91.1-0.81.1
Vertical activity count, locomotor time 20.70.80.9-0.90.8
Light reinforcement 11.32.54.7-2.20.4
Light reinforcement 20.91.11.7-1.3-0.7
Bone: marrow area1.12.33.0-1.71.3
Bone: maximum diameter2.54.64.8-2.12.2
Bone: maximum force3.35.86.2-2.32.5
Bone: maximum moment2.64.45.1-1.92.3
Mean time between licks in bursts0.30.40.50.7-0.6
Mean num. licks in bursts2.83.33.61.9-1.7
Cd content in liver1.01.11.3-0.91.2
Co content in liver1.21.41.91.0-1.4
Cu content in liver0.70.81.31.1-0.6
Fe content in liver0.40.40.7-0.8-0.5
K content in liver0.40.40.60.4-0.8
Mg content in liver1.11.21.31.1-1.0
Mn content in liver0.20.20.40.00.6
Na content in liver1.11.11.11.1-1.1
Rb content in liver4.35.45.82.2-2.4
Se content in liver2.02.53.2-1.31.8
Sr content in liver0.30.30.4-0.50.6
Zn content in liver0.20.20.30.30.5
Bone: minimum diameter0.00.10.10.3-0.1
Time in familiar zone, hab. session 10.50.50.91.00.2
Time in novel zone, hab. session 12.12.03.40.8-1.9
Total zone transitions, hab. session 10.00.00.0-0.00.1
Total locomotion distance, hab. session 10.50.71.2-0.41.1
Locomotion velocity, hab. session 11.72.53.3-1.31.8
Time in familiar zone, hab. session 20.50.51.01.0-0.2
Time in novel zone, hab. session 21.91.93.00.9-1.7
Total zone transitions, hab. session 20.50.71.0-1.00.5
Total locomotion distance, hab. session 20.91.11.2-1.11.0
Locomotion velocity, hab. session 21.11.51.6-1.21.2
Novel to familiar place preference ratio4.24.35.91.7-2.4
Novelty place preference5.65.77.32.0-2.7
Time in novel zone, NPP test6.76.98.82.2-3.0
Total zone transitions, NPP test0.71.01.5-1.20.6
Total locomotion distance, NPP test1.72.43.2-1.81.2
Locomotion velocity, NPP test2.33.34.1-2.01.6
Intraocular pressure2.12.93.9-2.01.3
Delta distance traveled before/after self-admin0.30.30.30.6-0.6
Delta ambulatory time before/after self-admin1.11.31.41.2-1.0
Parametrial fat weight0.20.40.5-0.70.6
Pavlov. Cond. lever latency8.310.512.03.5-3.0
Pavlov. Cond. magazine entry latency0.50.70.8-0.80.9
Pavlov. Cond. change in total contacts3.23.54.2-2.01.7
Pavlov. Cond. index score3.84.95.0-2.22.2
Pavlov. Cond. latency score3.54.44.7-2.22.0
Pavlov. Cond. lever contacts6.07.17.8-2.82.5
Pavlov. Cond. magazine entry number1.11.31.41.1-1.2
Pavlov. Cond. intertrial magazine entries0.20.30.3-0.50.6
Pavlov. Cond. lever-magazine prob. diff.3.54.44.6-2.02.2
Pavlov. Cond. response bias3.74.54.7-2.22.1
Pavlov. Cond. lever latency2.93.95.21.6-2.3
Pavlov. Cond. magazine entry latency0.30.30.40.6-0.4
Pavlov. Cond. change in total contacts1.01.42.4-0.51.6
Pavlov. Cond. index score0.30.40.7-0.10.9
Pavlov. Cond. latency score0.50.61.1-0.31.0
Pavlov. Cond. lever contacts1.41.92.5-1.11.6
Pavlov. Cond. magazine entry number0.20.20.4-0.1-0.6
Pavlov. Cond. intertrial magazine entries0.40.50.7-0.80.6
Pavlov. Cond. lever-magazine prob. diff.0.30.40.8-0.10.9
Pavlov. Cond. response bias0.60.81.3-0.61.1
Time in closed arm before self-admin2.83.23.41.9-1.7
Time in closed arm after self-admin0.20.30.50.7-0.1
Time in open arm before self-admin2.32.53.6-1.91.2
Time in open arm after self-admin1.31.52.3-1.50.8
Bone: periosteal estimation1.73.53.7-1.91.8
Bone: periosteal perimeter0.50.81.2-1.10.6
Bone: post-yield work1.52.12.8-1.71.2
Progressive ratio test 1 active lever presses0.50.50.9-1.0-0.4
Progressive ratio test 1 breakpoint0.60.61.2-1.1-0.2
Progressive ratio test 1 inactive lever presses0.80.91.6-1.3-0.3
Progressive ratio test 2 active lever presses0.50.50.7-0.8-0.6
Progressive ratio test 2 breakpoint0.40.50.7-0.5-0.8
Progressive ratio test 2 inactive lever presses0.70.81.6-1.30.2
Incentive Sensitization - Responses0.30.30.6-0.8-0.3
Incentive Sensitization - Breakpoint0.20.30.4-0.6-0.4
Sum of active levers in priming session hrs 5-64.44.25.11.8-2.2
Progressive ratio0.10.10.10.2-0.3
Food seeking constrained by brief footshock7.69.313.4-3.72.3
Seeking ratio, punishment vs. effort2.32.83.8-1.91.4
Retroperitoneal fat weight0.10.20.40.6-0.2
Reaction time number correct0.10.10.2-0.50.1
Reaction time mean minus median0.81.12.10.21.5
Reaction time mean minus median AUC1.11.52.8-0.41.7
Reaction time num false alarms0.00.00.00.10.2
Reaction time num false alarms AUC0.20.30.3-0.60.6
Reaction time trials correct on left0.10.10.2-0.50.1
Reaction time trials on left0.00.10.1-0.40.0
Reaction time mean1.21.73.21.8-0.4
Reaction time mean AUC1.52.13.92.0-0.5
Median of all reaction times2.43.35.02.2-1.3
Reaction time omissions1.52.02.71.7-1.1
Reaction time false alarm rate0.00.10.10.3-0.0
Reaction time premature initiation rate2.22.94.12.0-1.3
Reaction time premature initiations1.31.82.41.6-1.1
Std. dev. reaction times0.50.70.90.90.7
Reaction time trials completed0.00.10.1-0.40.0
Reaction time trials AUC0.00.10.1-0.30.0
Run reversals in cocaine runway, females0.20.20.30.30.6
Run reversals in cocaine runway, males0.00.00.00.2-0.1
Latency to leave start box in cocaine runway0.90.91.2-0.81.1
Latency to leave start box in cocaine runway, F0.00.00.00.2-0.0
Latency to leave start box in cocaine runway, M1.71.62.1-1.51.1
Std. dev. time between licks in bursts0.50.50.60.8-0.7
Total sessions with >9 infusions0.70.80.8-0.9-0.8
Short access day 1 total inactive lever presses2.93.25.5-2.40.9
Short access day 10 total inactive lever presses0.50.50.6-0.70.7
Short access day 1 total infusions2.32.55.0-2.20.1
Short access day 10 total infusions0.80.91.7-1.3-0.1
Short access total infusions1.11.22.2-1.5-0.5
Short access day 1 locomotion0.30.30.7-0.0-0.8
Short access day 10 total locomotion0.50.60.80.9-0.6
Short access total locomotion0.20.20.3-0.6-0.3
One hour access (0.3 mA shock)0.40.50.9-0.90.2
Compulsive drug intake0.10.10.1-0.40.3
One hour access (shock baseline)0.30.40.8-0.90.1
Social response proportion1.71.92.71.6-1.1
Social responses0.70.91.0-0.91.0
Social time0.00.00.00.0-0.1
Soleus weight0.20.50.8-0.4-0.9
Bone: stiffness4.67.27.7-2.62.8
Tibialis anterior weight7.726.230.7-5.54.7
Time to tail flick, vehicle, before self-admin2.12.23.21.8-1.1
Time to tail flick, vehicle, after self-admin0.00.00.0-0.2-0.1
Time to tail flick, test, before self-admin0.20.20.2-0.50.4
Time to tail flick, test, after self-admin0.70.71.2-0.51.1
Delta time to tail flick, vehicle, before/after SA0.60.61.0-1.00.4
Delta time to tail flick, test, before/after SA0.10.10.20.40.1
Tibia length0.10.20.3-0.5-0.4
Ambulatory time before self-admin3.84.06.1-2.51.3
Ambulatory time after self-admin0.30.30.5-0.70.2
Bone: tissue strength0.30.30.3-0.50.6
Total heroin consumption0.60.71.30.4-1.1
Bone: trabecular number1.21.92.6-1.11.6
Bone: trabecular spacing0.00.00.10.00.2
Bone: trabecular thickness0.20.20.30.5-0.3
Bone: trabecular tissue density3.14.44.8-2.22.0
Water consumed over 24 hours1.11.31.5-1.21.1
Number of responses in last shaping day0.80.81.3-1.1-0.6