Hub : Traits

Liver weight, right

Tags: Physiology · Liver · Weight

Project: dissection

4 loci · 8 genes with independent associations · 11 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	258396187	260518987	5	4	1.42e-08	9.72e-09	1e+00	Cacul1 Grk5 Prlhr Rab11fip2
2	chr9	75969545	77365260	1	1	6.62e-08	1.45e-02	1e+00	Zfand2b
3	chr20	5086090	6587967	4	2	5.80e-08	3.37e-08	1e+00	Ilrun Spdef
4	chr20	53722628	54429288	1	1	3.28e-10	9.37e-02	1e+00	LOC103694460

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	37.6	7	7	87.5	0.88	1.62e-03	Cacul1 Fam204a Grk5 LOC103694460 Prlhr Rab11fip2 Zfand2b
BMI without tail	27.65	7	6	75	0.96	3.06e-05	Cacul1 Fam204a Grk5 LOC103694460 Prlhr Rab11fip2 Zfand2b
Body weight	36.55	6	6	75	0.98	1.33e-05	Cacul1 Fam204a Grk5 LOC103694460 Prlhr Rab11fip2
Epididymis fat weight	47.45	9	9	112.5	0.57	5.41e-02	Cacul1 Fam204a Grk5 Ilrun Prlhr Rab11fip2 Snrpc Spdef Zfand2b
Glucose	5.78	1	0	0	0	1.00e+00	Ilrun
Heart weight	17.11	6	1	12.5	0.45	2.64e-01	Cacul1 Fam204a Grk5 Prlhr Rab11fip2 Zfand2b
Left kidney weight	16.54	7	7	87.5	0.73	2.50e-02	Cacul1 Fam204a Grk5 LOC103694460 Prlhr Rab11fip2 Zfand2b
Right kidney weight	19.89	7	7	87.5	0.64	6.42e-02	Cacul1 Fam204a Grk5 LOC103694460 Prlhr Rab11fip2 Zfand2b
Tail length	32.06	4	2	25	0.81	9.44e-02	Ilrun Snrpc Spdef Zfand2b
Length with tail	4.57	9	0	0	0.99	2.39e-10	Cacul1 Fam204a Grk5 Ilrun Prlhr Rab11fip2 Snrpc Spdef Zfand2b
Length without tail	16.76	6	1	12.5	0.41	3.19e-01	Cacul1 Fam204a Grk5 Prlhr Rab11fip2 Zfand2b
Liver weight, left	9.08	9	0	0	1	4.20e-12	Cacul1 Fam204a Grk5 Ilrun LOC103694460 Prlhr Rab11fip2 Snrpc Spdef
Parametrial fat weight	30.72	7	5	62.5	0.86	3.26e-03	Cacul1 Fam204a Grk5 LOC103694460 Prlhr Rab11fip2 Zfand2b
Retroperitoneal fat weight	54.11	7	6	75	0.97	1.87e-05	Cacul1 Fam204a Grk5 LOC103694460 Prlhr Rab11fip2 Zfand2b
Intraocular pressure	38.04	2	2	25	0	1.00e+00	LOC103694460 Zfand2b
Extensor digitorum longus weight	3.03	6	0	0	1	5.70e-08	Cacul1 Fam204a Grk5 LOC103694460 Prlhr Rab11fip2
Soleus weight	6.16	7	3	37.5	0.97	2.23e-05	Cacul1 Grk5 Ilrun Prlhr Rab11fip2 Snrpc Spdef
Tibialis anterior weight	11.7	1	1	12.5	0	1.00e+00	LOC103694460
Tibia length	3.78	4	0	0	1	1.43e-06	Ilrun LOC103694460 Snrpc Spdef
Number of licking bursts	32.5	1	1	12.5	0	1.00e+00	Zfand2b
Food consumed during 24 hour testing period	15.78	1	0	0	0	1.00e+00	Zfand2b
Times rat made contact with spout	9.25	1	0	0	0	1.00e+00	Zfand2b
Mean time between licks in bursts	7.8	4	0	0	1	3.05e-05	Ilrun Snrpc Spdef Zfand2b
Mean num. licks in bursts	18.13	1	0	0	0	1.00e+00	Zfand2b
Std. dev. time between licks in bursts	12.12	1	0	0	0	1.00e+00	Zfand2b
Water consumed over 24 hours	34.33	1	1	12.5	0	1.00e+00	Zfand2b
Patch foraging indifference point 0 sec	8.95	7	0	0	0.64	8.44e-02	Cacul1 Fam204a Grk5 LOC103694460 Prlhr Rab11fip2 Zfand2b
Patch foraging indifference point AUC	18.15	2	1	12.5	0	1.00e+00	LOC103694460 Zfand2b
Indifference point function ln k	54.42	1	1	12.5	0	1.00e+00	Zfand2b
Indifference point function log k	54.42	1	1	12.5	0	1.00e+00	Zfand2b
Patch foraging total patch changes 0 sec	10.97	7	1	12.5	0.71	3.38e-02	Cacul1 Fam204a Grk5 LOC103694460 Prlhr Rab11fip2 Zfand2b
Patch foraging total patch changes 12 sec	8.08	3	0	0	0	1.00e+00	Fam204a LOC103694460 Prlhr
Patch foraging total patch changes 18 sec	29.95	2	1	12.5	0	1.00e+00	LOC103694460 Zfand2b
Patch foraging total patch changes 24 sec	43.45	2	1	12.5	0	1.00e+00	LOC103694460 Zfand2b
Patch foraging total patch changes 6 sec	10.48	5	1	12.5	0.96	1.90e-03	Cacul1 Fam204a Grk5 Prlhr Zfand2b
Patch foraging time to switch 0 sec	19.87	2	1	12.5	0	1.00e+00	LOC103694460 Zfand2b
Patch foraging water rate 0 sec	22.51	2	1	12.5	0	1.00e+00	Rab11fip2 Zfand2b
Patch foraging water rate 12 sec	69.49	1	1	12.5	0	1.00e+00	Zfand2b
Patch foraging water rate 18 sec	9.71	1	0	0	0	1.00e+00	Zfand2b
Patch foraging water rate 24 sec	7.63	4	0	0	0.98	2.95e-03	Cacul1 Prlhr Rab11fip2 Zfand2b
Patch foraging water rate 6 sec	35.43	1	1	12.5	0	1.00e+00	Zfand2b
Locomotor activity	12.38	1	0	0	0	1.00e+00	Zfand2b
Locomotor testing distance	47.2	1	1	12.5	0	1.00e+00	Zfand2b
Locomotor testing rearing	99.51	1	1	12.5	0	1.00e+00	Zfand2b
Light reinforcement 1	13.75	2	1	12.5	0	1.00e+00	LOC103694460 Zfand2b
Light reinforcement 2	6.57	1	0	0	0	1.00e+00	Zfand2b
Reaction time number correct	114.79	1	1	12.5	0	1.00e+00	Zfand2b
Reaction time mean minus median	44.65	4	1	12.5	0.8	1.05e-01	Ilrun Snrpc Spdef Zfand2b
Reaction time mean minus median AUC	53.89	4	1	12.5	0.74	1.50e-01	Ilrun Snrpc Spdef Zfand2b
Reaction time num false alarms AUC	27.43	1	1	12.5	0	1.00e+00	Zfand2b
Reaction time trials correct on left	114.79	1	1	12.5	0	1.00e+00	Zfand2b
Reaction time trials on left	106.69	1	1	12.5	0	1.00e+00	Zfand2b
Reaction time mean	13.6	3	1	12.5	0.88	1.23e-01	Snrpc Spdef Zfand2b
Reaction time mean AUC	33.75	1	1	12.5	0	1.00e+00	Zfand2b
Median of all reaction times	17.65	1	0	0	0	1.00e+00	Zfand2b
Reaction time omissions	46.56	1	1	12.5	0	1.00e+00	Zfand2b
Reaction time premature initiations	41.6	1	1	12.5	0	1.00e+00	Zfand2b
Std. dev. reaction times	23.6	4	1	12.5	0.91	3.27e-02	Ilrun Snrpc Spdef Zfand2b
Reaction time trials completed	106.69	1	1	12.5	0	1.00e+00	Zfand2b
Reaction time trials AUC	108.76	1	1	12.5	0	1.00e+00	Zfand2b
Cocaine response after cond. corrected	12.71	1	0	0	0	1.00e+00	Zfand2b
Cocaine response after cond. not corrected	10.73	1	0	0	0	1.00e+00	Zfand2b
Saline control response	8.43	1	0	0	0	1.00e+00	Zfand2b
Pavlov. Cond. lever latency	9.22	1	0	0	0	1.00e+00	LOC103694460
Pavlov. Cond. index score	15.43	1	0	0	0	1.00e+00	LOC103694460
Pavlov. Cond. latency score	10.76	1	0	0	0	1.00e+00	LOC103694460
Pavlov. Cond. lever contacts	8.82	1	0	0	0	1.00e+00	LOC103694460
Pavlov. Cond. magazine entry number	20.26	1	0	0	0	1.00e+00	LOC103694460
Pavlov. Cond. lever-magazine prob. diff.	10.41	1	0	0	0	1.00e+00	LOC103694460
Pavlov. Cond. response bias	13.13	1	0	0	0	1.00e+00	LOC103694460
Conditioned reinforcement - actives	56.78	3	1	12.5	0	1.00e+00	Grk5 Prlhr Zfand2b
Conditioned reinforcement - inactives	135.63	1	1	12.5	0	1.00e+00	Zfand2b
Conditioned locomotion	13.93	1	0	0	0	1.00e+00	Zfand2b
Intermittent access intake day 1-15 change	156.77	1	1	12.5	0	1.00e+00	Zfand2b
Intermittent access intake escalation	117.41	1	1	12.5	0	1.00e+00	Zfand2b
Intermitt. access day 1 inactive lever presses	169.63	1	1	12.5	0	1.00e+00	Zfand2b
Intermitt. access day 15 inactive lever presses	294.26	1	1	12.5	0	1.00e+00	Zfand2b
Intermittent access day 1 total infusions	71.42	1	1	12.5	0	1.00e+00	Zfand2b
Intermittent access day 15 total infusions	35.39	1	1	12.5	0	1.00e+00	Zfand2b
Intermittent access terminal intake (last 3 days)	25.82	1	1	12.5	0	1.00e+00	Zfand2b
Intermittent access day 1 locomotion	26.47	1	1	12.5	0	1.00e+00	Zfand2b
Intermittent access day 15 total locomotion	93.08	1	1	12.5	0	1.00e+00	Zfand2b
Intermittent access total locomotion	12.43	1	0	0	0	1.00e+00	Zfand2b
Intermittent access standard deviation	442.51	1	1	12.5	0	1.00e+00	Zfand2b
Cocaine induced anxiety	125.35	1	1	12.5	0	1.00e+00	Zfand2b
Baseline Anxiety	393.92	1	1	12.5	0	1.00e+00	Zfand2b
Incentive Sensitization - Responses	309.83	1	1	12.5	0	1.00e+00	Zfand2b
Incentive Sensitization - Breakpoint	300.45	1	1	12.5	0	1.00e+00	Zfand2b
Progressive ratio test 1 active lever presses	26.41	1	1	12.5	0	1.00e+00	Zfand2b
Progressive ratio test 1 breakpoint	19.19	1	0	0	0	1.00e+00	Zfand2b
Progressive ratio test 2 active lever presses	109.22	1	1	12.5	0	1.00e+00	Zfand2b
Progressive ratio test 2 breakpoint	106.65	1	1	12.5	0	1.00e+00	Zfand2b
Progressive ratio test 2 inactive lever presses	63.47	1	1	12.5	0	1.00e+00	Zfand2b
Short access day 1 total inactive lever presses	21.93	1	0	0	0	1.00e+00	Zfand2b
Short access day 10 total inactive lever presses	25.33	2	1	12.5	0	1.00e+00	Prlhr Zfand2b
Short access day 1 locomotion	129.19	1	1	12.5	0	1.00e+00	Zfand2b
Short access day 10 total locomotion	432.47	1	1	12.5	0	1.00e+00	Zfand2b
Short access total locomotion	209.96	1	1	12.5	0	1.00e+00	Zfand2b
Compulsive drug intake	68.39	1	1	12.5	0	1.00e+00	Zfand2b
One hour access (0.3 mA shock)	22.58	1	0	0	0	1.00e+00	Zfand2b
Number of responses in last shaping day	67.75	1	1	12.5	0	1.00e+00	Zfand2b
Locomotion velocity, session 2	13.34	1	0	0	0	1.00e+00	LOC103694460
Locomotion distance, session 2	10.62	1	0	0	0	1.00e+00	LOC103694460
Locomotion velocity, session 3	7.97	1	0	0	0	1.00e+00	LOC103694460
Locomotion distance, session 7	9.27	1	0	0	0	1.00e+00	LOC103694460
Stereotopy head waving bouts, day 7	7.71	1	0	0	0	1.00e+00	LOC103694460
Stereotopy head waving duration, day 7	11.78	1	0	0	0	1.00e+00	LOC103694460
Locomotion velocity, session 8	7.38	3	0	0	1	1.69e-07	Ilrun Snrpc Spdef
Locomotion distance, session 8	8.35	1	0	0	0	1.00e+00	LOC103694460
Condit. Reinf. inactive responses	8.04	3	0	0	1	5.64e-07	Cacul1 Grk5 Prlhr
Pavlov. Cond. intertrial magazine entries	7.44	1	0	0	0	1.00e+00	LOC103694460
Bone: apparent density	6.85	5	0	0	1	3.67e-08	Cacul1 Fam204a Grk5 Prlhr Rab11fip2
Bone surface	5.81	4	0	0	1	2.42e-05	Cacul1 Grk5 Prlhr Rab11fip2
Bone volume	8.87	5	0	0	1	1.39e-08	Cacul1 Fam204a Grk5 Prlhr Rab11fip2
Bone: cortical apparent density	8.15	5	0	0	-1	1.78e-07	Cacul1 Fam204a Grk5 Prlhr Rab11fip2
Bone: cortical area	15.07	6	0	0	0.99	6.47e-06	Cacul1 Fam204a Grk5 LOC103694460 Prlhr Rab11fip2
Bone: cortical porosity	16.96	1	0	0	0	1.00e+00	LOC103694460
Bone: cortical porosity	8.89	1	0	0	0	1.00e+00	LOC103694460
Bone: cortical thickness	9	8	0	0	0.36	2.77e-01	Cacul1 Fam204a Grk5 Ilrun Prlhr Rab11fip2 Snrpc Spdef
Bone: cortical thickness	8.96	1	0	0	0	1.00e+00	Prlhr
Bone: cortical tissue density	9.08	5	0	0	-1	9.98e-08	Cacul1 Fam204a Grk5 Prlhr Rab11fip2
Bone: elastic work	11.21	1	0	0	0	1.00e+00	LOC103694460
Bone: endosteal estimation	6.96	4	0	0	0.99	1.67e-03	Ilrun LOC103694460 Snrpc Spdef
Bone: endosteal perimeter	9.14	4	1	12.5	0.96	1.13e-02	Ilrun LOC103694460 Snrpc Spdef
Bone: final force	10.58	5	0	0	1	1.85e-08	Cacul1 Fam204a Grk5 Prlhr Rab11fip2
Bone: final moment	11.31	5	0	0	1	8.18e-09	Cacul1 Fam204a Grk5 Prlhr Rab11fip2
Bone: marrow area	7.47	3	0	0	1	1.10e-04	Ilrun Snrpc Spdef
Bone: maximum diameter	9.45	6	1	12.5	0.98	1.22e-05	Cacul1 Fam204a Grk5 LOC103694460 Prlhr Rab11fip2
Bone: maximum force	10.13	5	0	0	1	5.26e-09	Cacul1 Fam204a Grk5 Prlhr Rab11fip2
Bone: maximum moment	10.58	5	0	0	1	4.40e-10	Cacul1 Fam204a Grk5 Prlhr Rab11fip2
Bone: minimum diameter	7.39	6	0	0	1	1.01e-11	Cacul1 Fam204a Grk5 LOC103694460 Prlhr Rab11fip2
Bone: periosteal estimation	10.21	5	0	0	1	7.70e-10	Cacul1 Fam204a Grk5 Prlhr Rab11fip2
Bone: periosteal perimeter	10.09	6	0	0	1	3.60e-10	Cacul1 Fam204a Grk5 LOC103694460 Prlhr Rab11fip2
Bone: stiffness	5.4	1	0	0	0	1.00e+00	Rab11fip2
Bone: trabecular spacing	8.2	1	0	0	0	1.00e+00	LOC103694460
Bone: trabecular thickness	14.32	5	0	0	1	8.24e-08	Cacul1 Fam204a Grk5 Prlhr Rab11fip2
Bone: trabecular tissue density	10.67	1	0	0	0	1.00e+00	LOC103694460
Distance traveled after self-admin	8.9	1	0	0	0	1.00e+00	Zfand2b
Delta time in open arm before/after self-admin	26.67	1	0	0	0	1.00e+00	Zfand2b
Active lever presses in extinction session 6	26.41	1	0	0	0	1.00e+00	Zfand2b
Time in closed arm before self-admin	44.32	1	1	12.5	0	1.00e+00	Zfand2b
Time in open arm before self-admin	24.67	1	0	0	0	1.00e+00	Zfand2b
Time to tail flick, vehicle, after self-admin	75.62	1	1	12.5	0	1.00e+00	Zfand2b
Time to tail flick, test, before self-admin	10.68	1	0	0	0	1.00e+00	Zfand2b
Delta time to tail flick, vehicle, before/after SA	74.6	1	1	12.5	0	1.00e+00	Zfand2b
Ambulatory time before self-admin	25.36	1	0	0	0	1.00e+00	Zfand2b
Area under the delay curve	31.15	1	1	12.5	0	1.00e+00	Zfand2b
Delay disc. indifference point, 16s delay	69.03	1	1	12.5	0	1.00e+00	Zfand2b
Delay disc. indifference point, 24s delay	27.43	1	0	0	0	1.00e+00	Zfand2b
Delay disc. indifference point, 8s delay	74.24	1	1	12.5	0	1.00e+00	Zfand2b
Delay discount exponential model param	16.14	1	0	0	0	1.00e+00	Zfand2b
Delay discount hyperbolic model param	15.89	1	0	0	0	1.00e+00	Zfand2b
Fecal boli incidents, locomotor time 1	176.47	1	1	12.5	0	1.00e+00	Zfand2b
Time >=10cm from walls, locomotor time 1	79.04	1	1	12.5	0	1.00e+00	Zfand2b
Rest time, locomotor task time 1	11.47	1	0	0	0	1.00e+00	Zfand2b
Vertical activity count, locomotor time 1	97.7	1	1	12.5	0	1.00e+00	Zfand2b
Bouts of movement, locomotor time 2	23.9	1	0	0	0	1.00e+00	Zfand2b
Total resting periods, locomotor time 2	36.28	1	1	12.5	0	1.00e+00	Zfand2b
Rest time, locomotor task time 2	44.91	1	1	12.5	0	1.00e+00	Zfand2b
Distance moved, locomotor task time 2	83.87	1	1	12.5	0	1.00e+00	Zfand2b
Vertical activity count, locomotor time 2	13.16	1	0	0	0	1.00e+00	Zfand2b
Weight adjusted by age	8.82	2	0	0	0	1.00e+00	Rab11fip2 Zfand2b
Seeking ratio, delayed vs. immediate footshock	8.74	1	0	0	0	1.00e+00	Zfand2b
Locomotion in novel chamber post-restriction	14.04	1	0	0	0	1.00e+00	Zfand2b
Food seeking constrained by brief footshock	9.23	4	0	0	-0.62	1.92e-01	Cacul1 Grk5 Prlhr Zfand2b
Run reversals in cocaine runway, females	36.45	1	1	12.5	0	1.00e+00	Zfand2b
Latency to leave start box in cocaine runway	34.23	1	1	12.5	0	1.00e+00	Zfand2b
Latency to leave start box in cocaine runway, F	31.9	1	1	12.5	0	1.00e+00	Zfand2b
Co content in liver	7.64	1	0	0	0	1.00e+00	LOC103694460
Cu content in liver	43.87	1	1	12.5	0	1.00e+00	LOC103694460
Fe content in liver	26.96	1	1	12.5	0	1.00e+00	LOC103694460
K content in liver	46.75	1	1	12.5	0	1.00e+00	LOC103694460
Mg content in liver	13.38	1	0	0	0	1.00e+00	LOC103694460
Mn content in liver	11.94	3	0	0	1	2.83e-05	Ilrun Snrpc Spdef
Na content in liver	13.35	1	0	0	0	1.00e+00	LOC103694460
Rb content in liver	81.33	1	1	12.5	0	1.00e+00	LOC103694460
Se content in liver	8.6	4	0	0	0.62	2.61e-01	Ilrun LOC103694460 Snrpc Spdef
Sr content in liver	15.77	2	0	0	0	1.00e+00	Cacul1 LOC103694460

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.67
Adipose	alternative TSS	0	0	1.61
Adipose	gene expression	2	0	1.61
Adipose	isoform ratio	0	0	1.67
Adipose	intron excision ratio	0	0	1.91
Adipose	mRNA stability	0	0	1.6
BLA	alternative polyA	1	0	1.64
BLA	alternative TSS	0	0	1.61
BLA	gene expression	0	0	1.67
BLA	isoform ratio	0	0	1.69
BLA	intron excision ratio	0	0	1.67
BLA	mRNA stability	1	0	1.72
Brain	alternative polyA	0	0	1.64
Brain	alternative TSS	0	0	1.69
Brain	gene expression	0	0	1.65
Brain	isoform ratio	1	0	1.66
Brain	intron excision ratio	0	0	1.72
Brain	mRNA stability	0	0	1.62
Eye	alternative polyA	0	0	2.03
Eye	alternative TSS	0	0	1.63
Eye	gene expression	0	0	1.75
Eye	isoform ratio	0	0	1.68
Eye	intron excision ratio	0	0	1.73
Eye	mRNA stability	0	0	1.8
IL	alternative polyA	0	0	1.66
IL	alternative TSS	0	0	1.64
IL	gene expression	0	0	1.62
IL	isoform ratio	0	0	1.67
IL	intron excision ratio	0	0	1.54
IL	mRNA stability	0	0	1.69
LHb	alternative polyA	0	0	1.63
LHb	alternative TSS	0	0	1.58
LHb	gene expression	1	0	1.72
LHb	isoform ratio	0	0	1.71
LHb	intron excision ratio	0	0	1.78
LHb	mRNA stability	0	0	1.71
Liver	alternative polyA	0	0	1.72
Liver	alternative TSS	1	0	1.63
Liver	gene expression	0	0	1.59
Liver	isoform ratio	1	0	1.69
Liver	intron excision ratio	0	0	1.76
Liver	mRNA stability	0	0	1.71
NAcc	alternative polyA	0	0	1.65
NAcc	alternative TSS	0	0	1.68
NAcc	gene expression	1	0	1.64
NAcc	isoform ratio	0	0	1.66
NAcc	intron excision ratio	0	0	1.66
NAcc	mRNA stability	1	0	1.67
OFC	alternative polyA	0	0	1.72
OFC	alternative TSS	0	0	1.61
OFC	gene expression	0	0	1.69
OFC	isoform ratio	0	0	1.72
OFC	intron excision ratio	0	0	1.84
OFC	mRNA stability	0	0	1.83
PL	alternative polyA	0	0	1.61
PL	alternative TSS	0	0	1.66
PL	gene expression	0	0	1.62
PL	isoform ratio	1	0	1.64
PL	intron excision ratio	1	0	1.66
PL	mRNA stability	0	0	1.65
pVTA	alternative polyA	0	0	1.6
pVTA	alternative TSS	0	0	1.49
pVTA	gene expression	1	0	1.7
pVTA	isoform ratio	0	0	1.66
pVTA	intron excision ratio	0	0	1.67
pVTA	mRNA stability	0	0	1.67
RMTg	alternative polyA	0	0	1.72
RMTg	alternative TSS	0	0	1.68
RMTg	gene expression	0	0	1.66
RMTg	isoform ratio	0	0	1.79
RMTg	intron excision ratio	0	0	1.75
RMTg	mRNA stability	0	0	1.61