Liver weight, right

Tags: Physiology · Liver · Weight

2 loci · 5 genes with independent associations · 9 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	258394596	260518987	4	1	1.49e-08	9.72e-09	1e+00	Cacul1
2	20	5086090	7380732	5	4	5.80e-08	3.37e-08	1e+00	Spdef Taf11 Ilrun ENSRNOG00000058912

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr	Corr P	Genes
BMI with tail	40.86	4	4	80	1	4.99e-15	Rab11fip2 Prlhr Cacul1 Sfxn4
BMI without tail	26.78	4	4	80	1	1.21e-13	Rab11fip2 Prlhr Cacul1 Sfxn4
Body weight	34.61	5	4	80	0.98	6.97e-09	Srpk1 Rab11fip2 Prlhr Cacul1 Sfxn4
Epididymis fat weight	44.55	8	7	140	0.69	3.01e-03	Spdef Rab11fip2 Prlhr Cacul1 Taf11 Sfxn4 Ilrun ENSRNOG00000058912
Glucose	7.63	2	0	0	1	4.10e-04	Cacul1 Taf11
Heart weight	9.49	4	0	0	1	1.87e-11	Rab11fip2 Prlhr Cacul1 Sfxn4
Left kidney weight	13.63	4	4	80	0.99	2.51e-10	Rab11fip2 Prlhr Cacul1 Sfxn4
Right kidney weight	12.8	5	4	80	0.98	1.17e-09	Srpk1 Rab11fip2 Prlhr Cacul1 Sfxn4
Tail length	7.75	5	2	40	1	4.75e-05	Spdef Srpk1 Taf11 Ilrun ENSRNOG00000058912
Length with tail	4.31	9	0	0	0.99	3.23e-15	Spdef Srpk1 Rab11fip2 Prlhr Cacul1 Taf11 Sfxn4 Ilrun ENSRNOG00000058912
Length without tail	7.1	4	0	0	1	8.99e-14	Rab11fip2 Prlhr Cacul1 Sfxn4
Liver weight, left	8.98	9	0	0	1	1.74e-17	Spdef Srpk1 Rab11fip2 Prlhr Cacul1 Taf11 Sfxn4 Ilrun ENSRNOG00000058912
Parametrial fat weight	35.98	4	4	80	1	4.94e-18	Rab11fip2 Prlhr Cacul1 Sfxn4
Retroperitoneal fat weight	61.53	4	4	80	1	8.29e-17	Rab11fip2 Prlhr Cacul1 Sfxn4
Extensor digitorum longus weight	2.71	4	0	0	1	5.44e-11	Rab11fip2 Prlhr Cacul1 Sfxn4
Soleus weight	6.09	7	3	60	0.98	4.72e-06	Spdef Srpk1 Rab11fip2 Cacul1 Taf11 Ilrun ENSRNOG00000058912
Tibia length	3.65	4	0	0	1	5.10e-04	Spdef Srpk1 Ilrun ENSRNOG00000058912
Mean time between licks in bursts	8.11	3	0	0	0	1.00e+00	Spdef Taf11 ENSRNOG00000058912
Indifference point 0 sec	6.9	3	0	0	1	1.38e-15	Rab11fip2 Cacul1 Sfxn4
Delay discounting total patch changes 0 sec	8.04	4	0	0	1	1.37e-15	Rab11fip2 Prlhr Cacul1 Sfxn4
Delay discounting total patch changes 6 sec	6.17	1	0	0	0	1.00e+00	Cacul1
Delay discounting water rate 24 sec	6.58	1	0	0	0	1.00e+00	Rab11fip2
Reaction time mean minus median	10.44	4	0	0	1	2.83e-04	Spdef Taf11 Ilrun ENSRNOG00000058912
Reaction time mean minus median AUC	9.2	3	0	0	0	1.00e+00	Spdef Taf11 ENSRNOG00000058912
Std. dev. reaction times	10.92	4	0	0	1	2.18e-04	Spdef Taf11 Ilrun ENSRNOG00000058912
Cocaine response after cond. not corrected	8.51	1	0	0	0	1.00e+00	Cacul1
Conditioned reinforcement - actives	9.68	1	0	0	0	1.00e+00	Cacul1
Locomotion velocity, session 8	8.18	1	0	0	0	1.00e+00	Taf11
Condit. Reinf. inactive responses	8.69	1	0	0	0	1.00e+00	Cacul1
Bone: apparent density	6.81	4	0	0	1	3.85e-13	Rab11fip2 Prlhr Cacul1 Sfxn4
Bone surface	5.6	4	0	0	1	2.93e-11	Rab11fip2 Prlhr Cacul1 Sfxn4
Bone volume	8.5	4	0	0	1	2.13e-13	Rab11fip2 Prlhr Cacul1 Sfxn4
Bone: cortical apparent density	9.02	4	0	0	-1	4.74e-12	Rab11fip2 Prlhr Cacul1 Sfxn4
Bone: cortical area	15.33	4	0	0	1	3.96e-16	Rab11fip2 Prlhr Cacul1 Sfxn4
Bone: cortical thickness	8.43	8	0	0	0.55	2.84e-02	Spdef Rab11fip2 Prlhr Cacul1 Taf11 Sfxn4 Ilrun ENSRNOG00000058912
Bone: cortical tissue density	9.93	4	0	0	-1	2.87e-12	Rab11fip2 Prlhr Cacul1 Sfxn4
Bone: endosteal estimation	7.02	5	0	0	1	3.96e-05	Spdef Srpk1 Taf11 Ilrun ENSRNOG00000058912
Bone: endosteal perimeter	5.12	4	0	0	1	4.93e-04	Spdef Srpk1 Ilrun ENSRNOG00000058912
Bone: final force	9.31	4	0	0	1	1.72e-12	Rab11fip2 Prlhr Cacul1 Sfxn4
Bone: final moment	10.18	4	0	0	1	3.03e-12	Rab11fip2 Prlhr Cacul1 Sfxn4
Bone: marrow area	6.89	5	0	0	1	4.98e-05	Spdef Srpk1 Taf11 Ilrun ENSRNOG00000058912
Bone: maximum diameter	7.9	4	0	0	1	1.83e-12	Rab11fip2 Prlhr Cacul1 Sfxn4
Bone: maximum force	8.98	4	0	0	1	1.67e-12	Rab11fip2 Prlhr Cacul1 Sfxn4
Bone: maximum moment	9.55	4	0	0	1	4.65e-12	Rab11fip2 Prlhr Cacul1 Sfxn4
Bone: minimum diameter	7.21	4	0	0	1	1.42e-12	Rab11fip2 Prlhr Cacul1 Sfxn4
Bone: periosteal estimation	10.01	4	0	0	1	1.61e-14	Rab11fip2 Prlhr Cacul1 Sfxn4
Bone: periosteal perimeter	9.95	4	0	0	1	3.29e-12	Rab11fip2 Prlhr Cacul1 Sfxn4
Bone: trabecular thickness	13.66	4	0	0	1	2.09e-13	Rab11fip2 Prlhr Cacul1 Sfxn4
Seeking ratio, delayed vs. immediate footshock	8.49	1	0	0	0	1.00e+00	Cacul1
Food seeking constrained by brief footshock	8.53	2	0	0	-0.99	6.39e-05	Cacul1 Sfxn4
Cu content in liver	7.56	1	0	0	0	1.00e+00	Ilrun
Mn content in liver	11.32	4	0	0	1	6.78e-04	Spdef Taf11 Ilrun ENSRNOG00000058912
Se content in liver	8.91	3	0	0	0	1.00e+00	Spdef Taf11 ENSRNOG00000058912

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.71
Adipose	alternative TSS	0	0	1.5
Adipose	gene expression	1	0	1.61
Adipose	isoform ratio	0	0	1.63
Adipose	intron excision ratio	0	0	1.89
Adipose	mRNA stability	0	0	1.59
BLA	alternative polyA	0	0	1.48
BLA	alternative TSS	0	0	1.7
BLA	gene expression	1	0	1.67
BLA	isoform ratio	0	0	1.51
BLA	intron excision ratio	0	0	1.68
BLA	mRNA stability	0	0	1.69
Brain	alternative polyA	0	0	1.55
Brain	alternative TSS	0	0	1.81
Brain	gene expression	0	0	1.66
Brain	isoform ratio	1	0	1.62
Brain	intron excision ratio	1	0	1.74
Brain	mRNA stability	0	0	1.63
Eye	alternative polyA	0	0	2
Eye	alternative TSS	0	0	1.92
Eye	gene expression	0	0	1.7
Eye	isoform ratio	0	0	1.78
Eye	intron excision ratio	0	0	1.8
Eye	mRNA stability	0	0	1.48
IL	alternative polyA	0	0	1.3
IL	alternative TSS	0	0	1.76
IL	gene expression	0	0	1.65
IL	isoform ratio	0	0	1.66
IL	intron excision ratio	0	0	1.52
IL	mRNA stability	0	0	1.67
LHb	alternative polyA	0	0	1.67
LHb	alternative TSS	0	0	1.56
LHb	gene expression	0	0	1.7
LHb	isoform ratio	0	0	1.73
LHb	intron excision ratio	0	0	1.72
LHb	mRNA stability	0	0	1.73
Liver	alternative polyA	0	0	1.56
Liver	alternative TSS	0	0	1.57
Liver	gene expression	1	0	1.61
Liver	isoform ratio	1	0	1.66
Liver	intron excision ratio	0	0	1.7
Liver	mRNA stability	1	0	1.66
NAcc	alternative polyA	0	0	1.57
NAcc	alternative TSS	0	0	1.88
NAcc	gene expression	2	0	1.68
NAcc	isoform ratio	2	0.1	1.69
NAcc	intron excision ratio	0	0	1.75
NAcc	mRNA stability	0	0	1.64
OFC	alternative polyA	0	0	1.5
OFC	alternative TSS	0	0	1.83
OFC	gene expression	2	0.1	1.73
OFC	isoform ratio	0	0	1.65
OFC	intron excision ratio	1	0.1	1.88
OFC	mRNA stability	1	0.1	1.83
PL	alternative polyA	0	0	1.61
PL	alternative TSS	0	0	1.66
PL	gene expression	1	0	1.65
PL	isoform ratio	1	0	1.62
PL	intron excision ratio	0	0	1.7
PL	mRNA stability	0	0	1.65