LOC120100575

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	LOC120100575	0.08	0.05	4.0e-09	0.07	0.06	0.06	0.07	3.4e-10	6.2e-10	1.4e-09	2.8e-10
2	IC	gene expression	LOC120100575	0.25	0.54	3.6e-04	0.13	0.06	0.09	0.12	5.4e-06	1.2e-03	1.2e-04	1.4e-05
3	BLA	gene expression	LOC120100575	0.23	0.1	4.5e-12	0.18	0.19	0.18	0.19	1.1e-09	1.6e-10	7.2e-10	2.8e-10
4	PL	gene expression	LOC120100575	0.09	0.06	8.0e-10	0.08	0.07	0.08	0.05	9.6e-09	3.7e-08	4.1e-09	3.6e-06
5	Brain	gene expression	LOC120100575	0.06	0.04	1.3e-04	0.03	0.05	0.04	0.04	1.4e-03	2.0e-05	7.8e-05	1.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.0	0.0	0.1	0.2	-0.1	0.2	-0.4	-0.0
Area under the delay curve	0.9	1.4	2.5	1.2	-1.3	0.9	-0.7	1.6
BMI with tail	4.7	16.5	18.6	4.3	-4.1	4.2	-4.1	3.6
BMI without tail	1.5	8.2	9.7	3.1	-2.6	3.0	-2.9	2.6
Body weight	4.0	17.5	23.4	4.3	-4.8	4.2	-4.0	3.4
Weight adjusted by age	0.1	0.2	0.4	-0.1	0.6	0.1	-0.6	-0.6
Bone surface	1.0	1.9	2.5	1.5	-1.4	1.5	-1.6	0.6
Bone volume	0.1	0.2	0.4	0.6	-0.4	0.5	-0.7	0.1
Breakpoint value in progressive ratio session	0.6	1.1	1.4	1.0	-1.1	1.2	-1.0	1.0
Number of licking bursts	1.0	3.2	4.1	1.9	-1.6	1.9	-2.0	1.3
Context. condit. distance diff. score	0.6	0.7	0.9	-1.0	0.9	-0.9	0.9	-0.3
Locomotion velocity, session 1	0.4	0.4	0.8	0.6	-0.6	0.7	-0.9	-0.4
Locomotion distance, session 1	1.2	1.6	2.0	1.4	-1.4	1.4	-1.3	0.4
Locomotion velocity, session 2	0.4	0.5	1.4	0.6	-0.3	0.8	-1.2	-0.4
Locomotion distance, session 2	0.1	0.1	0.2	0.3	-0.2	0.4	-0.3	-0.4
Locomotion velocity, session 3	0.1	0.1	0.2	-0.4	0.1	-0.2	0.3	-0.3
Locomotion distance, session 3	0.1	0.1	0.1	-0.2	-0.1	-0.2	0.3	-0.4
Stereotopy head waving bouts, day 3	0.1	0.2	0.5	-0.2	-0.1	0.2	-0.6	-0.7
Stereotopy head waving duration, day 3	0.2	0.3	0.9	0.1	-0.3	0.6	-0.9	0.3
Locomotion velocity, session 7	0.1	0.1	0.1	0.2	0.0	0.2	-0.3	-0.4
Locomotion distance, session 7	3.9	5.0	6.3	-2.2	2.5	-2.2	2.4	-1.8
Stereotopy head waving bouts, day 7	1.0	1.2	2.3	0.9	-1.2	1.2	-1.5	0.1
Stereotopy head waving duration, day 7	1.4	1.7	3.7	1.0	-1.3	1.4	-1.9	0.1
Locomotion velocity, session 8	0.8	0.9	1.2	1.1	-0.7	1.0	-1.1	0.9
Locomotion distance, session 8	0.0	0.1	0.1	0.3	-0.2	0.3	-0.3	0.2
Degree of sensitization distance	4.0	4.3	6.1	-2.0	2.5	-2.1	2.1	-1.6
Degree of sensitization stereotypy	1.6	1.7	2.9	1.4	-1.3	1.4	-1.7	0.5
Conditioned locomotion	2.4	2.8	3.4	-1.8	1.7	-1.7	1.6	-1.4
Cocaine response after cond. corrected	0.3	0.5	0.9	-0.5	0.6	-0.8	1.0	0.0
Cocaine response after cond. not corrected	0.2	0.3	0.6	-0.4	0.6	-0.7	0.8	-0.2
Cocaine response before conditioning	0.6	0.7	1.4	0.9	-0.6	1.0	-1.2	0.2
Saline control response	0.8	1.1	1.9	0.8	-1.4	1.1	-1.0	0.8
Bone: connectivity density	1.6	2.5	3.9	1.6	-1.5	1.8	-2.0	0.8
Bone: cortical apparent density	1.5	2.3	3.4	-1.7	1.2	-1.5	1.3	-1.8
Bone: cortical area	0.8	1.2	1.6	1.3	-1.2	1.1	-1.0	0.9
Bone: cortical porosity	1.5	1.6	2.5	1.3	-0.9	1.2	-1.3	1.6
Bone: cortical porosity	1.7	1.9	2.8	1.4	-1.1	1.3	-1.4	1.7
Bone: cortical thickness	0.1	0.2	0.3	0.4	-0.5	0.3	-0.1	0.5
Bone: cortical thickness	0.6	0.7	0.9	0.9	-0.9	0.9	-0.9	0.6
Bone: cortical tissue density	1.4	2.3	3.4	-1.7	1.1	-1.4	1.3	-1.9
Condit. Reinf. active minus inactive responses	0.4	0.5	0.8	0.7	-0.8	0.6	-0.3	0.9
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.6	0.7	-0.9	0.5	-0.3	1.3
Condit. Reinf. active responses	2.0	2.6	3.8	1.7	-1.9	1.6	-1.2	1.6
Condit. Reinf. inactive responses	2.6	3.4	4.5	1.9	-2.1	2.0	-1.9	1.1
Incentive salience index mean	0.5	0.7	0.9	0.9	-1.0	0.7	-0.4	1.0
Condit. Reinf. lever presses	0.6	0.9	1.5	1.1	-1.2	0.9	-0.7	0.5
Condit. Reinf. active minus inactive responses	0.4	0.6	1.1	1.0	-0.9	0.6	-0.1	0.9
Condit. Reinf. active-inactive response ratio	0.4	0.6	1.7	-0.2	0.5	-0.9	1.3	0.2
Condit. Reinf. active responses	1.4	2.1	3.1	1.7	-1.8	1.5	-1.1	1.1
Condit. Reinf. inactive responses	4.7	6.9	8.9	2.6	-2.9	3.0	-2.9	1.6
Condit. Reinf. lever presses	0.6	0.9	1.9	1.2	-0.7	0.8	-0.4	1.4
Condit. Reinf. lever reinforcers received	1.2	1.7	2.6	1.5	-1.6	1.3	-0.9	1.0
Conditioned reinforcement - actives	0.8	3.1	5.2	-2.0	1.3	-1.4	1.6	-2.3
Conditioned reinforcement - inactives	0.3	0.9	1.4	-0.9	1.0	-0.9	1.2	-0.6
Conditioned locomotion	0.4	0.6	1.4	-0.7	0.4	-0.5	0.7	-1.2
Patch foraging indifference point 0 sec	0.9	2.6	3.7	1.3	-1.9	1.6	-1.7	1.5
Patch foraging indifference point AUC	0.3	0.8	2.0	0.9	-0.2	1.1	-1.4	0.1
Delay disc. indifference point, 0s delay	0.7	0.8	1.5	-0.7	0.7	-0.9	0.8	-1.2
Delay disc. indifference point, 16s delay	1.2	1.7	3.1	1.3	-1.3	1.1	-0.9	1.8
Delay disc. indifference point, 2s delay	0.4	0.5	0.8	0.8	-0.9	0.4	-0.3	0.9
Delay disc. indifference point, 24s delay	0.0	0.1	0.3	0.1	-0.2	0.0	-0.1	0.6
Delay disc. indifference point, 4s delay	1.9	2.1	2.4	1.5	-1.6	1.4	-1.2	1.5
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	0.1	-0.3	-0.3	0.4	0.5
Indifference point function ln k	0.2	0.5	1.2	-0.4	-0.2	-0.8	1.1	0.4
Indifference point function log k	0.2	0.5	1.2	-0.4	-0.2	-0.8	1.1	0.4
Patch foraging total patch changes 0 sec	0.8	2.4	3.3	1.2	-1.8	1.5	-1.7	1.5
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	-0.4	0.4	-0.0	-0.2	-0.4
Patch foraging total patch changes 18 sec	0.5	1.1	1.6	0.7	-1.3	1.1	-1.2	0.8
Patch foraging total patch changes 24 sec	1.0	3.4	5.0	1.7	-1.8	2.1	-2.2	1.3
Patch foraging total patch changes 6 sec	1.6	2.6	4.4	1.2	-1.6	1.8	-2.1	1.3
Patch foraging time to switch 0 sec	0.8	3.0	4.1	-1.8	1.6	-1.9	2.0	-1.4
Patch foraging water rate 0 sec	0.2	0.7	1.4	0.7	-0.7	0.9	-1.2	0.6
Patch foraging water rate 12 sec	0.1	0.5	0.9	0.6	-0.8	0.8	-1.0	0.1
Patch foraging water rate 18 sec	0.2	0.5	0.8	0.7	-0.9	0.7	-0.9	0.2
Patch foraging water rate 24 sec	0.5	0.7	1.2	0.5	-1.1	0.9	-1.1	-0.1
Patch foraging water rate 6 sec	0.1	0.1	0.3	-0.1	-0.6	0.1	-0.0	-0.3
Seeking ratio, delayed vs. immediate footshock	2.4	3.4	4.6	1.9	-1.9	1.9	-1.4	2.1
Distance traveled before self-admin	1.8	3.9	5.4	2.1	-1.8	2.1	-2.3	1.6
Distance traveled after self-admin	2.2	3.8	5.4	2.1	-1.9	2.1	-2.3	1.3
Extensor digitorum longus weight	4.8	19.3	20.1	4.5	-4.4	4.4	-4.2	4.5
Bone: elastic displacement	0.6	0.8	1.4	-0.7	0.7	-1.0	1.2	0.6
Bone: elastic work	1.2	1.6	2.6	-1.3	1.1	-1.5	1.6	-0.4
Bone: endosteal estimation	1.1	2.7	3.3	1.8	-1.7	1.8	-1.7	1.1
Bone: endosteal perimeter	0.4	0.9	1.7	1.0	-1.3	1.0	-0.9	0.2
Epididymis fat weight	2.1	10.5	12.9	3.3	-3.6	3.2	-2.8	3.2
Delta time in closed arm before/after self-admin	1.4	1.3	2.3	1.1	-1.5	1.1	-1.1	0.9
Delta time in open arm before/after self-admin	0.5	0.6	0.8	-0.7	0.8	-0.9	0.9	-0.7
Diff in mean of infusions in LGA sessions	0.2	0.3	0.6	0.7	-0.0	0.4	-0.4	0.7
Delay discount exponential model param	1.0	1.4	2.6	-1.2	1.3	-0.8	0.7	-1.6
Extinction: sum of active levers before priming	0.3	0.4	0.9	-0.1	-0.9	-0.5	0.9	-0.3
Active lever presses in extinction session 6	0.2	0.2	0.5	-0.1	0.2	-0.4	0.7	0.4
Bone: final force	3.3	5.4	6.8	2.5	-2.6	2.4	-2.2	2.0
Bone: final moment	3.3	5.4	6.8	2.4	-2.6	2.3	-2.2	2.0
Food consumed during 24 hour testing period	0.0	0.1	0.2	0.2	0.3	-0.1	0.3	0.5
Glucose	0.3	0.4	0.6	-0.7	0.7	-0.6	0.8	-0.4
Heart weight	3.1	5.1	8.4	2.2	-2.5	1.9	-1.3	2.9
Delay discount hyperbolic model param	1.0	1.3	2.5	-1.2	1.3	-0.8	0.6	-1.6
Intermittent access intake day 1-15 change	0.4	2.2	2.4	-1.5	1.6	-1.5	1.4	-1.5
Intermittent access intake escalation	0.3	1.5	1.6	-1.2	1.2	-1.3	1.1	-1.2
Intermittent access intake escalation 2	0.4	0.7	0.9	-0.9	0.8	-0.9	0.7	-0.8
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	-0.3	0.1	-0.2	0.4	0.1
Intermitt. access day 15 inactive lever presses	0.1	0.4	1.1	0.6	-0.8	0.4	-0.2	1.0
Intermitt. access escalation Index	0.2	0.6	1.2	-0.9	0.8	-0.8	1.1	-0.2
Intermittent access day 1 total infusions	1.0	3.1	5.0	-1.5	1.7	-1.5	1.7	-2.2
Intermittent access day 15 total infusions	1.7	4.1	5.7	-2.0	1.7	-1.9	2.0	-2.4
Intermittent access terminal intake (last 3 days)	2.8	5.0	6.1	-2.2	2.1	-2.1	2.3	-2.5
Intermittent access total infusions	1.4	1.7	3.7	-1.2	0.8	-1.0	1.2	-1.9
Intermittent access day 1 locomotion	0.4	0.8	1.9	-0.7	0.9	-0.6	0.7	-1.4
Intermittent access day 15 total locomotion	0.2	0.6	1.2	-0.8	0.3	-0.7	1.1	-0.8
Intermittent access total locomotion	0.4	0.5	1.4	-0.5	0.5	-0.4	0.5	-1.2
Intermittent access standard deviation	0.0	0.1	0.1	-0.4	-0.0	-0.3	0.4	-0.0
Left kidney weight	0.3	2.7	3.4	1.8	-1.8	1.5	-1.4	1.6
Right kidney weight	1.1	7.7	8.9	2.8	-3.0	2.7	-2.4	3.0
Cocaine induced anxiety	0.4	1.2	2.8	1.3	-0.8	0.8	-0.2	1.7
Post-drug Anxiety	1.0	1.2	2.8	1.1	-0.7	1.0	-0.7	1.7
Baseline Anxiety	0.2	0.3	0.5	-0.5	0.7	0.0	-0.6	-0.6
Tail length	0.2	1.0	1.8	0.9	-1.4	0.9	-0.8	0.8
Length with tail	0.9	3.9	7.7	1.9	-2.8	1.9	-1.7	1.4
Length without tail	1.3	7.0	11.8	2.6	-3.4	2.5	-2.3	2.2
Times rat made contact with spout	0.5	0.6	1.1	-0.8	0.7	-0.8	1.0	-0.4
Lifetime Intake	1.4	1.7	3.5	-1.2	0.8	-1.0	1.3	-1.9
Liver weight, left	0.0	0.1	0.3	0.3	-0.5	0.0	0.0	-0.2
Liver weight, right	0.2	0.3	0.8	-0.9	0.4	-0.5	0.3	-0.4
Locomotor activity	0.3	0.5	1.2	0.5	-1.0	0.2	-0.0	1.1
Locomotor testing distance	2.3	5.7	9.1	2.3	-3.0	2.2	-1.6	2.7
Locomotor testing rearing	0.1	0.5	1.1	0.5	-1.0	0.6	-0.4	1.0
Locomotion in novel chamber	0.4	0.6	1.1	0.6	-1.0	0.7	-0.7	0.7
Locomotion in novel chamber post-restriction	0.4	1.3	2.1	1.2	-0.8	1.3	-1.4	0.9
Fecal boli incidents, locomotor time 1	0.5	1.2	2.1	-0.9	1.0	-1.3	1.5	-0.5
Change in fecal boli incidents, locomotor task	2.0	2.1	3.1	1.3	-1.8	1.6	-1.5	1.0
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.2	0.1	-0.3	0.3	-0.5
Bouts of movement, locomotor time 1	0.7	0.9	1.4	-0.9	0.7	-1.1	1.2	-0.7
Total resting periods, locomotor time 1	1.8	2.1	3.6	-1.4	1.2	-1.6	1.9	-0.9
Rest time, locomotor task time 1	2.0	3.2	6.0	-1.8	1.3	-2.1	2.5	-1.0
Distance moved, locomotor task time 1	0.9	2.6	4.2	1.5	-1.6	1.9	-2.1	0.6
Vertical activity count, locomotor time 1	0.3	2.4	4.5	1.3	-1.4	1.8	-2.1	0.7
Time >=10cm from walls, locomotor time 2	0.3	0.9	1.2	-0.9	0.7	-1.0	1.1	-0.9
Bouts of movement, locomotor time 2	0.6	1.9	2.5	-1.6	1.6	-1.5	1.3	-0.9
Total resting periods, locomotor time 2	0.2	1.0	1.3	-1.1	1.2	-1.1	0.9	-0.5
Rest time, locomotor task time 2	0.1	0.2	0.5	-0.5	0.2	-0.6	0.7	0.0
Distance moved, locomotor task time 2	0.9	1.2	1.8	1.3	-0.9	1.3	-1.3	0.3
Vertical activity count, locomotor time 2	0.3	0.6	1.2	0.9	-0.6	1.0	-1.1	-0.1
Light reinforcement 1	0.1	0.6	1.3	-0.8	0.3	-0.9	1.2	-0.5
Light reinforcement 2	0.1	0.3	0.4	-0.5	0.4	-0.6	0.6	-0.4
Bone: marrow area	1.2	2.9	3.5	1.9	-1.8	1.8	-1.7	1.1
Bone: maximum diameter	0.5	1.0	1.4	1.0	-1.0	1.2	-1.2	0.3
Bone: maximum force	0.9	1.8	2.3	1.5	-1.5	1.3	-1.1	1.2
Bone: maximum moment	1.0	1.8	2.4	1.5	-1.5	1.3	-1.1	1.3
Mean time between licks in bursts	0.1	0.3	0.4	-0.6	0.4	-0.7	0.6	-0.6
Mean num. licks in bursts	1.4	3.7	5.4	-2.1	1.7	-2.1	2.3	-1.1
Cd content in liver	1.3	1.4	1.6	-1.3	1.2	-1.2	1.1	-1.2
Co content in liver	1.0	1.1	2.3	1.0	-1.0	0.9	-0.7	1.5
Cu content in liver	0.3	0.4	0.5	0.7	-0.5	0.6	-0.5	0.6
Fe content in liver	0.1	0.1	0.1	-0.2	0.3	-0.3	0.3	0.2
K content in liver	0.2	0.2	0.5	-0.4	0.7	-0.4	0.2	-0.4
Mg content in liver	0.2	0.2	0.4	-0.4	0.2	-0.5	0.7	-0.1
Mn content in liver	1.2	1.3	1.5	-1.2	1.1	-1.2	1.1	-1.1
Na content in liver	1.1	1.2	1.8	1.0	-1.3	1.3	-1.2	0.4
Rb content in liver	1.5	1.7	2.8	1.3	-1.4	1.1	-1.0	1.7
Se content in liver	1.7	2.1	2.6	-1.4	1.4	-1.4	1.2	-1.6
Sr content in liver	0.1	0.1	0.2	0.3	0.2	0.3	-0.4	-0.2
Zn content in liver	0.0	0.0	0.1	0.1	0.2	-0.1	0.3	0.3
Bone: minimum diameter	1.0	1.9	2.8	1.7	-1.4	1.4	-1.1	1.3
Time in familiar zone, hab. session 1	0.2	0.2	0.4	-0.4	0.5	-0.5	0.6	-0.3
Time in novel zone, hab. session 1	0.2	0.2	0.6	0.2	-0.5	0.6	-0.8	-0.0
Total zone transitions, hab. session 1	2.0	2.7	4.3	1.8	-1.4	1.6	-1.2	2.1
Total locomotion distance, hab. session 1	1.5	2.1	2.6	1.4	-1.3	1.6	-1.5	1.5
Locomotion velocity, hab. session 1	1.9	2.7	3.2	1.7	-1.4	1.8	-1.6	1.8
Time in familiar zone, hab. session 2	1.7	1.9	2.3	-1.5	1.4	-1.4	1.1	-1.5
Time in novel zone, hab. session 2	1.6	1.8	2.0	1.4	-1.4	1.4	-1.1	1.4
Total zone transitions, hab. session 2	2.3	3.0	3.7	1.9	-1.7	1.9	-1.7	1.4
Total locomotion distance, hab. session 2	0.9	1.2	1.7	1.2	-0.9	1.3	-1.0	1.1
Locomotion velocity, hab. session 2	1.3	1.7	2.3	1.5	-1.1	1.5	-1.3	1.1
Novel to familiar place preference ratio	0.1	0.2	0.5	0.4	0.2	0.3	-0.4	0.7
Novelty place preference	0.2	0.2	0.7	0.4	0.1	0.3	-0.5	0.8
Time in novel zone, NPP test	0.5	0.6	1.3	0.6	-0.2	0.6	-0.8	1.1
Total zone transitions, NPP test	0.4	0.6	0.8	0.9	-0.8	0.9	-0.8	-0.0
Total locomotion distance, NPP test	0.2	0.3	0.5	0.7	-0.4	0.7	-0.7	0.0
Locomotion velocity, NPP test	0.1	0.2	0.3	0.5	-0.2	0.5	-0.4	-0.2
Intraocular pressure	1.0	1.6	2.6	-1.2	1.0	-1.4	1.6	-0.8
Delta distance traveled before/after self-admin	0.1	0.1	0.3	-0.1	0.1	-0.1	-0.2	-0.5
Delta ambulatory time before/after self-admin	0.0	0.1	0.1	0.1	-0.4	0.1	-0.4	-0.2
Parametrial fat weight	0.6	1.5	2.1	1.3	-1.4	1.2	-1.2	0.7
Pavlov. Cond. lever latency	0.3	0.4	0.7	-0.8	0.8	-0.6	0.6	-0.1
Pavlov. Cond. magazine entry latency	2.0	2.5	3.5	1.9	-1.7	1.6	-1.6	1.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.4	-0.5	0.4	-0.4	0.1
Pavlov. Cond. index score	1.6	2.1	2.7	1.6	-1.5	1.5	-1.6	0.6
Pavlov. Cond. latency score	1.1	1.4	1.9	1.4	-1.3	1.3	-1.3	0.4
Pavlov. Cond. lever contacts	0.6	0.7	1.1	1.0	-0.9	0.9	-0.8	0.2
Pavlov. Cond. magazine entry number	2.3	2.9	3.4	-1.8	1.9	-1.8	1.8	-1.1
Pavlov. Cond. intertrial magazine entries	1.5	1.8	2.9	-1.4	1.3	-1.5	1.7	-0.7
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.1	2.8	1.7	-1.5	1.5	-1.6	0.6
Pavlov. Cond. response bias	1.8	2.3	3.0	1.7	-1.6	1.6	-1.6	0.8
Pavlov. Cond. lever latency	3.4	4.7	5.6	-2.4	2.0	-2.4	2.2	-1.9
Pavlov. Cond. magazine entry latency	0.8	1.1	2.4	1.0	-0.8	1.0	-0.8	1.5
Pavlov. Cond. change in total contacts	2.8	6.9	8.1	2.9	-2.8	2.7	-2.3	2.5
Pavlov. Cond. index score	3.6	5.7	6.2	2.5	-2.3	2.5	-2.2	2.5
Pavlov. Cond. latency score	2.6	4.1	4.8	2.1	-1.9	2.1	-1.8	2.2
Pavlov. Cond. lever contacts	3.1	4.6	5.7	2.3	-2.0	2.4	-2.3	1.7
Pavlov. Cond. magazine entry number	3.4	4.4	5.9	-2.1	2.0	-2.1	1.8	-2.4
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.4	0.5	-0.3	0.2	-0.4
Pavlov. Cond. lever-magazine prob. diff.	3.3	5.1	5.6	2.4	-2.2	2.4	-2.1	2.3
Pavlov. Cond. response bias	4.4	6.1	6.8	2.6	-2.3	2.6	-2.5	2.3
Time in closed arm before self-admin	0.8	1.5	3.1	-1.2	1.8	-1.0	0.8	-1.0
Time in closed arm after self-admin	0.1	0.1	0.2	-0.5	0.2	-0.4	0.4	-0.3
Time in open arm before self-admin	5.6	6.9	7.5	2.7	-2.7	2.6	-2.6	2.4
Time in open arm after self-admin	0.3	0.3	0.4	0.6	-0.7	0.4	-0.4	0.6
Bone: periosteal estimation	1.1	2.7	3.3	1.8	-1.8	1.7	-1.6	1.1
Bone: periosteal perimeter	0.3	0.6	1.1	0.8	-1.0	0.9	-0.8	0.3
Bone: post-yield work	0.0	0.0	0.2	0.5	-0.1	-0.0	0.1	0.0
Progressive ratio test 1 active lever presses	0.3	0.5	2.1	-0.6	0.1	-0.2	0.5	-1.4
Progressive ratio test 1 breakpoint	0.3	0.6	2.3	-0.7	0.1	-0.2	0.4	-1.5
Progressive ratio test 1 inactive lever presses	0.2	0.6	1.3	-0.7	0.8	-0.5	0.5	-1.2
Progressive ratio test 2 active lever presses	1.6	2.3	6.1	-1.4	1.0	-1.1	1.1	-2.5
Progressive ratio test 2 breakpoint	1.7	2.2	5.8	-1.3	1.0	-1.0	1.0	-2.4
Progressive ratio test 2 inactive lever presses	0.3	1.0	1.7	-0.9	0.8	-1.0	1.3	-1.0
Incentive Sensitization - Responses	0.9	2.4	4.1	-1.3	1.4	-1.5	1.5	-2.0
Incentive Sensitization - Breakpoint	1.0	2.2	3.8	-1.2	1.4	-1.4	1.4	-1.9
Sum of active levers in priming session hrs 5-6	0.1	0.0	0.2	0.4	-0.1	-0.0	0.2	0.1
Progressive ratio	0.1	0.2	0.4	-0.4	-0.2	-0.4	0.6	-0.1
Food seeking constrained by brief footshock	0.5	0.6	1.3	0.6	-1.1	0.5	0.1	1.1
Seeking ratio, punishment vs. effort	0.2	0.4	0.5	0.7	-0.5	0.7	-0.7	0.7
Retroperitoneal fat weight	2.4	10.8	12.6	3.5	-3.4	3.5	-3.4	2.5
Reaction time number correct	0.2	0.7	2.7	-0.8	0.5	-0.4	0.1	-1.6
Reaction time mean minus median	0.6	3.8	8.9	2.2	-1.2	1.6	-1.2	3.0
Reaction time mean minus median AUC	0.3	1.9	4.3	1.5	-0.9	1.2	-0.8	2.1
Reaction time num false alarms	0.1	0.1	0.1	-0.3	0.3	-0.3	0.4	0.0
Reaction time num false alarms AUC	0.1	0.2	0.3	-0.5	0.5	-0.4	0.3	-0.4
Reaction time trials correct on left	0.2	0.7	2.7	-0.8	0.5	-0.4	0.1	-1.6
Reaction time trials on left	0.2	0.7	2.4	-0.8	0.5	-0.4	0.1	-1.6
Reaction time mean	0.8	1.8	5.7	1.5	-0.8	0.8	-0.1	2.4
Reaction time mean AUC	0.7	1.7	5.6	1.4	-0.7	0.7	-0.1	2.4
Median of all reaction times	0.5	0.7	2.7	0.8	-0.3	0.2	0.5	1.6
Reaction time omissions	1.1	1.8	6.6	1.1	-1.0	0.5	0.1	2.6
Reaction time false alarm rate	0.1	0.1	0.3	0.2	-0.1	0.1	-0.1	0.6
Reaction time premature initiation rate	2.0	3.1	4.4	-1.6	2.1	-1.9	1.7	-1.5
Reaction time premature initiations	1.0	3.1	4.1	-1.7	1.9	-1.7	1.3	-2.0
Std. dev. reaction times	1.2	4.1	9.1	2.3	-1.5	1.6	-1.1	3.0
Reaction time trials completed	0.2	0.7	2.4	-0.8	0.5	-0.4	0.1	-1.6
Reaction time trials AUC	0.2	0.6	2.3	-0.8	0.4	-0.4	0.1	-1.5
Run reversals in cocaine runway, females	0.5	0.6	1.5	0.4	-0.6	0.9	-1.2	0.1
Run reversals in cocaine runway, males	0.6	0.6	0.9	0.8	-1.0	0.8	-0.6	0.7
Latency to leave start box in cocaine runway	0.3	0.4	1.0	-0.2	0.2	-0.5	1.0	0.9
Latency to leave start box in cocaine runway, F	0.9	1.1	2.5	-1.0	0.7	-1.1	1.6	-0.0
Latency to leave start box in cocaine runway, M	1.0	0.9	2.9	1.0	-0.5	0.6	-0.3	1.7
Std. dev. time between licks in bursts	0.3	0.6	1.3	0.8	-0.6	0.6	-0.4	1.1
Total sessions with >9 infusions	1.8	2.3	3.6	-1.4	1.0	-1.4	1.9	-1.7
Short access day 1 total inactive lever presses	0.2	0.4	0.9	-0.8	0.3	-0.5	0.6	-1.0
Short access day 10 total inactive lever presses	0.2	1.1	1.9	0.9	-1.0	1.0	-1.1	1.4
Short access day 1 total infusions	0.9	1.8	2.6	-1.4	0.8	-1.2	1.5	-1.6
Short access day 10 total infusions	0.3	0.6	1.6	-0.6	0.5	-0.4	0.7	-1.3
Short access total infusions	1.6	2.2	4.0	-1.4	1.1	-1.2	1.6	-2.0
Short access day 1 locomotion	0.1	0.1	0.3	-0.4	0.0	-0.2	0.5	-0.3
Short access day 10 total locomotion	0.0	0.0	0.0	0.1	0.1	0.1	0.1	-0.2
Short access total locomotion	0.1	0.2	0.4	-0.2	0.2	-0.2	0.5	-0.6
One hour access (0.3 mA shock)	1.4	1.6	4.7	-1.4	0.3	-0.8	0.8	-2.2
Compulsive drug intake	1.3	1.9	3.0	1.2	-1.7	1.4	-1.5	0.9
One hour access (shock baseline)	1.6	4.3	6.4	-2.1	1.8	-1.9	1.9	-2.5
Social response proportion	6.7	8.5	9.8	-3.0	3.1	-3.0	3.1	-2.3
Social responses	0.6	0.8	1.4	-1.0	0.8	-0.8	0.6	-1.2
Social time	3.6	5.7	8.1	-2.3	2.8	-2.6	2.5	-1.5
Soleus weight	0.8	2.3	2.9	1.3	-1.4	1.5	-1.7	1.6
Bone: stiffness	1.1	2.0	2.4	1.6	-1.5	1.5	-1.5	0.9
Tibialis anterior weight	7.3	25.0	28.3	5.0	-5.3	5.2	-5.2	4.1
Time to tail flick, vehicle, before self-admin	0.9	1.1	1.5	-1.1	1.2	-1.0	1.2	-0.4
Time to tail flick, vehicle, after self-admin	1.1	2.3	2.7	-1.1	1.7	-1.6	1.4	-1.6
Time to tail flick, test, before self-admin	1.0	1.2	2.6	1.2	-0.4	0.9	-0.9	1.6
Time to tail flick, test, after self-admin	0.3	0.3	0.7	0.2	-0.7	0.5	-0.5	0.8
Delta time to tail flick, vehicle, before/after SA	1.5	1.6	2.4	-1.0	1.1	-1.4	1.2	-1.6
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	-0.1	-0.5	0.3	-0.2	-0.1
Tibia length	1.0	2.9	7.8	-1.3	1.3	-1.4	1.1	-2.8
Ambulatory time before self-admin	0.6	1.8	2.7	1.4	-1.0	1.5	-1.7	0.9
Ambulatory time after self-admin	0.9	1.4	2.6	1.2	-1.1	1.3	-1.6	0.5
Bone: tissue strength	0.2	0.2	0.5	-0.0	0.0	-0.3	0.4	0.7
Total heroin consumption	0.3	0.3	0.5	0.4	-0.6	0.5	-0.5	0.7
Bone: trabecular number	0.4	0.8	1.9	0.8	-0.6	1.0	-1.4	0.3
Bone: trabecular spacing	0.9	1.2	1.6	-1.0	1.1	-1.1	1.3	-1.0
Bone: trabecular thickness	0.4	0.6	1.0	-0.7	1.0	-0.7	0.4	-0.9
Bone: trabecular tissue density	1.9	3.4	4.2	-2.0	1.7	-2.0	2.0	-1.3
Water consumed over 24 hours	0.2	0.4	0.7	0.7	-0.5	0.6	-0.3	0.8
Number of responses in last shaping day	0.1	0.1	0.2	0.1	0.1	0.4	-0.4	-0.2