Ddb1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Ddb1	0.14	0.06	6.0e-07	0.04	0.04	0.02	0.03	3.7e-05	7.0e-05	1.3e-03	3.9e-04
2	NAcc	mRNA stability	Ddb1	0.03	0.02	1.8e-04	0.02	0.02	0.02	0.03	2.0e-04	1.2e-04	6.8e-04	4.6e-05
3	pVTA	mRNA stability	Ddb1	0.07	0.05	3.9e-04	0.03	0.04	0.03	0.03	1.8e-03	2.2e-04	9.1e-04	1.3e-03
4	IC	mRNA stability	Ddb1	0.09	0.06	4.0e-03	0.06	0.04	0.04	0.04	1.5e-03	8.1e-03	9.0e-03	7.6e-03
5	Brain	mRNA stability	Ddb1	0.09	0.04	7.2e-10	0.12	0.1	0.11	0.11	6.3e-11	5.8e-10	2.4e-10	9.6e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.1	0.2	0.4	-0.5	0.6	0.4	0.6	-0.3
Area under the delay curve	0.8	1.0	2.2	-0.9	0.8	1.1	1.5	0.0
BMI with tail	1.0	3.4	11.5	2.0	-0.2	1.0	0.8	-3.4
BMI without tail	0.4	1.3	3.6	1.3	-0.3	0.5	0.9	-1.9
Body weight	1.1	4.8	14.6	2.9	-0.5	0.5	0.5	-3.8
Weight adjusted by age	1.6	2.4	3.9	2.0	-1.7	-0.6	-1.5	-1.6
Bone surface	0.3	0.6	1.0	0.7	0.7	1.0	0.8	-0.7
Bone volume	0.3	0.5	1.1	0.2	1.1	1.0	0.7	-0.2
Breakpoint value in progressive ratio session	2.9	3.5	4.4	1.9	-2.0	-1.9	-2.1	-1.5
Number of licking bursts	0.1	0.1	0.3	0.2	0.5	0.3	0.3	-0.2
Context. condit. distance diff. score	0.1	0.1	0.2	-0.0	0.2	0.4	0.2	-0.3
Locomotion velocity, session 1	0.5	0.6	1.4	0.5	-1.2	-0.4	-0.8	-0.6
Locomotion distance, session 1	1.0	1.3	2.4	0.0	-1.4	-1.1	-0.9	-1.5
Locomotion velocity, session 2	0.8	1.0	3.1	0.2	-0.9	-0.9	-0.4	-1.7
Locomotion distance, session 2	1.1	1.5	2.4	0.2	-1.5	-1.3	-1.0	-1.6
Locomotion velocity, session 3	1.0	1.2	2.7	-0.7	1.0	1.1	1.7	-0.7
Locomotion distance, session 3	0.6	0.6	1.1	-0.5	0.8	0.7	1.0	0.8
Stereotopy head waving bouts, day 3	0.6	0.7	1.4	-1.2	0.3	0.7	1.1	-0.7
Stereotopy head waving duration, day 3	0.4	0.5	1.0	-0.4	0.1	0.6	0.9	-1.0
Locomotion velocity, session 7	0.6	0.6	1.0	-0.9	0.8	0.8	1.0	-0.0
Locomotion distance, session 7	0.3	0.4	0.8	-0.6	0.5	0.8	0.9	-0.1
Stereotopy head waving bouts, day 7	0.1	0.1	0.4	0.7	-0.1	0.4	-0.1	-0.1
Stereotopy head waving duration, day 7	0.3	0.4	1.2	1.1	-0.4	0.0	-0.2	-0.7
Locomotion velocity, session 8	0.3	0.3	1.3	1.1	-0.4	0.0	-0.3	0.2
Locomotion distance, session 8	0.1	0.1	0.2	-0.5	0.0	0.3	0.3	-0.5
Degree of sensitization distance	0.5	0.5	2.1	-0.1	-0.2	0.5	0.1	-1.5
Degree of sensitization stereotypy	0.6	0.6	2.4	1.6	-0.4	0.2	-0.5	-0.6
Conditioned locomotion	0.3	0.3	1.0	0.0	-0.6	-0.1	0.3	-1.0
Cocaine response after cond. corrected	0.2	0.3	0.6	0.3	-0.8	0.0	-0.3	-0.7
Cocaine response after cond. not corrected	0.1	0.1	0.4	-0.1	-0.6	-0.0	-0.5	-0.3
Cocaine response before conditioning	0.4	0.4	0.9	-0.4	0.2	-0.6	-0.9	0.8
Saline control response	1.4	1.8	2.4	1.4	-1.5	-1.2	-1.2	-1.3
Bone: connectivity density	0.2	0.3	1.5	0.1	-0.0	0.2	0.4	-1.2
Bone: cortical apparent density	0.5	0.6	1.7	-0.4	-0.5	-1.3	-0.8	-0.6
Bone: cortical area	0.2	0.2	0.8	-0.9	0.3	-0.5	-0.1	0.1
Bone: cortical porosity	0.5	0.5	1.3	1.1	-0.9	-0.6	-0.4	-0.1
Bone: cortical porosity	0.6	0.7	1.5	1.2	-1.1	-0.6	-0.4	-0.3
Bone: cortical thickness	2.4	4.0	9.0	0.2	-2.1	-3.0	-2.2	-1.4
Bone: cortical thickness	0.4	0.4	1.1	-0.9	-0.4	-1.1	-0.2	-0.1
Bone: cortical tissue density	0.6	0.8	1.9	-0.1	-0.7	-1.4	-0.9	-0.8
Condit. Reinf. active minus inactive responses	1.7	1.9	2.5	0.6	-1.6	-1.5	-1.6	-1.4
Condit. Reinf. active-inactive response ratio	3.0	3.2	4.8	1.1	-2.2	-1.9	-2.1	-1.4
Condit. Reinf. active responses	0.9	1.1	1.9	-0.3	-1.0	-1.3	-1.0	-1.4
Condit. Reinf. inactive responses	0.5	0.6	1.7	-1.3	0.9	0.3	0.6	-0.1
Incentive salience index mean	0.6	0.7	1.1	-0.6	-0.7	-1.1	-0.7	-1.1
Condit. Reinf. lever presses	0.4	0.6	2.0	-1.4	0.7	0.0	0.5	-0.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	-0.3	-0.4	-0.5	-0.7	-0.1
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.3	0.6	0.6	1.1	0.4	-0.4
Condit. Reinf. active responses	0.2	0.3	0.6	-0.3	-0.4	-0.8	-0.8	-0.2
Condit. Reinf. inactive responses	0.5	0.7	1.4	-0.8	-0.4	-1.2	-0.9	0.6
Condit. Reinf. lever presses	0.1	0.2	0.5	0.7	0.2	-0.0	-0.3	-0.6
Condit. Reinf. lever reinforcers received	0.4	0.6	1.2	0.4	-0.7	-0.9	-1.1	-0.5
Conditioned reinforcement - actives	0.1	0.2	0.5	0.5	-0.1	-0.1	-0.5	0.7
Conditioned reinforcement - inactives	0.2	0.3	0.9	-0.4	0.9	0.6	0.5	0.1
Conditioned locomotion	2.4	3.2	4.4	-1.9	2.1	1.6	1.8	1.4
Patch foraging indifference point 0 sec	0.1	0.2	0.6	-0.1	-0.5	-0.8	-0.3	-0.3
Patch foraging indifference point AUC	0.9	1.3	3.6	-0.5	-0.7	-1.9	-1.1	-0.9
Delay disc. indifference point, 0s delay	1.1	1.2	3.4	-0.1	1.0	1.8	1.2	0.1
Delay disc. indifference point, 16s delay	0.2	0.2	0.6	-0.5	0.4	0.4	0.8	-0.1
Delay disc. indifference point, 2s delay	1.8	2.1	4.0	-0.9	1.7	2.0	1.4	0.8
Delay disc. indifference point, 24s delay	0.5	0.5	1.6	-1.2	0.4	0.2	1.0	-0.1
Delay disc. indifference point, 4s delay	0.9	1.0	2.3	-0.8	0.8	1.1	1.5	-0.2
Delay disc. indifference point, 8s delay	0.9	1.0	2.4	-0.7	0.8	1.2	1.5	0.4
Indifference point function ln k	1.3	2.4	5.2	-0.5	1.5	2.3	1.5	1.3
Indifference point function log k	1.3	2.4	5.2	-0.5	1.5	2.3	1.5	1.3
Patch foraging total patch changes 0 sec	0.3	0.5	1.4	-0.3	-0.8	-1.2	-0.6	-0.4
Patch foraging total patch changes 12 sec	3.4	4.4	8.1	0.6	-2.2	-2.8	-1.9	-2.2
Patch foraging total patch changes 18 sec	0.8	1.3	2.7	0.1	-1.1	-1.6	-1.4	-0.7
Patch foraging total patch changes 24 sec	1.4	2.4	6.6	0.3	-1.1	-1.9	-0.8	-2.6
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	-0.1	0.0	-0.7	-0.2	-0.5
Patch foraging time to switch 0 sec	0.3	0.7	1.7	0.8	0.4	1.3	0.8	-0.3
Patch foraging water rate 0 sec	0.4	0.9	2.0	-1.4	0.1	-1.0	-0.5	1.1
Patch foraging water rate 12 sec	0.3	0.6	1.3	-1.1	0.5	0.2	0.2	1.1
Patch foraging water rate 18 sec	0.5	0.7	1.9	-1.4	0.8	0.2	0.7	0.7
Patch foraging water rate 24 sec	0.2	0.3	1.1	0.0	0.5	0.5	0.2	1.1
Patch foraging water rate 6 sec	0.3	0.4	1.0	-1.0	0.3	-0.1	-0.0	0.9
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	2.0	-1.4	0.6	-0.1	0.3	-0.6
Distance traveled before self-admin	0.5	0.7	1.3	1.1	-0.1	-0.1	-1.1	-0.9
Distance traveled after self-admin	0.4	0.5	1.0	0.3	-0.6	-1.0	-1.0	-0.5
Extensor digitorum longus weight	2.3	9.0	24.8	3.2	-2.4	-1.7	-1.1	-5.0
Bone: elastic displacement	0.6	0.6	1.3	0.1	-1.1	-1.0	-1.0	0.1
Bone: elastic work	1.3	1.7	2.8	0.7	-1.5	-1.7	-1.4	-1.1
Bone: endosteal estimation	3.1	6.7	10.0	-1.6	3.0	3.2	3.1	1.5
Bone: endosteal perimeter	4.4	9.3	15.8	-1.4	3.7	4.0	3.3	2.1
Epididymis fat weight	1.4	4.7	9.5	-1.7	3.1	2.6	1.7	1.3
Delta time in closed arm before/after self-admin	2.2	2.1	4.0	0.6	-1.7	-1.5	-0.9	-2.0
Delta time in open arm before/after self-admin	0.7	0.6	1.3	0.2	-0.8	-1.1	-0.3	-1.1
Diff in mean of infusions in LGA sessions	1.9	2.3	2.9	1.3	-1.7	-1.7	-1.1	-1.7
Delay discount exponential model param	1.0	1.1	2.4	1.0	-0.9	-1.1	-1.6	-0.1
Extinction: sum of active levers before priming	0.9	1.0	3.2	0.6	-0.9	-0.6	-0.0	-1.8
Active lever presses in extinction session 6	0.9	0.9	1.5	1.2	-0.7	-0.8	-1.0	-0.9
Bone: final force	0.1	0.2	0.5	-0.3	-0.0	-0.5	-0.1	-0.7
Bone: final moment	0.1	0.2	0.5	-0.3	-0.1	-0.6	-0.2	-0.7
Food consumed during 24 hour testing period	0.1	0.2	0.8	-0.2	0.1	-0.1	-0.4	0.9
Glucose	1.5	2.4	5.5	-0.9	1.5	2.4	1.3	1.3
Heart weight	1.9	3.0	6.5	-0.2	1.6	2.4	2.6	-0.1
Delay discount hyperbolic model param	1.2	1.3	2.6	1.0	-1.1	-1.3	-1.6	-0.2
Intermittent access intake day 1-15 change	0.5	1.1	2.6	-1.3	1.0	0.2	0.1	1.6
Intermittent access intake escalation	0.5	1.1	2.7	-1.3	1.0	0.2	-0.0	1.6
Intermittent access intake escalation 2	0.3	0.4	0.8	-0.7	0.7	-0.1	-0.3	0.9
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.2	0.2	0.2	-0.1	0.3
Intermitt. access day 15 inactive lever presses	0.4	0.7	2.0	-0.7	1.4	0.7	0.6	-0.6
Intermitt. access escalation Index	1.5	2.1	6.9	-2.6	0.9	0.3	1.4	0.9
Intermittent access day 1 total infusions	2.9	4.7	7.8	-1.6	2.5	2.6	2.8	-0.1
Intermittent access day 15 total infusions	4.0	6.0	8.6	-2.8	2.9	2.2	2.3	1.8
Intermittent access terminal intake (last 3 days)	2.8	3.7	6.3	-2.0	2.5	2.0	1.9	0.8
Intermittent access total infusions	4.1	4.9	7.1	-2.2	2.7	2.3	2.6	0.8
Intermittent access day 1 locomotion	1.8	2.3	5.0	-1.3	1.5	1.5	2.2	-0.4
Intermittent access day 15 total locomotion	0.8	1.5	3.2	-0.7	1.8	1.6	1.1	-0.2
Intermittent access total locomotion	4.1	5.0	8.1	-2.0	2.8	2.4	2.6	0.0
Intermittent access standard deviation	0.1	0.1	0.3	0.0	0.1	-0.0	-0.5	0.6
Left kidney weight	1.2	5.4	9.8	-0.4	2.7	3.0	3.1	0.9
Right kidney weight	0.4	2.0	3.4	-0.9	1.5	1.8	1.8	0.4
Cocaine induced anxiety	0.6	0.8	2.3	1.1	-0.7	-0.4	-1.5	-0.1
Post-drug Anxiety	0.6	0.6	2.1	1.5	-0.3	0.3	-0.9	-0.4
Baseline Anxiety	0.2	0.2	0.5	-0.2	0.3	0.3	0.7	-0.5
Tail length	0.3	1.1	2.0	0.7	-1.1	-1.4	-0.8	-1.0
Length with tail	0.4	1.9	4.0	2.0	-0.8	-0.7	-0.8	-1.9
Length without tail	1.2	3.8	7.1	2.5	-1.4	-1.1	-1.6	-2.7
Times rat made contact with spout	0.9	1.0	1.6	0.7	-1.2	-1.3	-1.2	-0.7
Lifetime Intake	2.8	3.4	5.4	-1.6	2.1	2.1	2.3	0.4
Liver weight, left	0.2	0.3	0.7	-0.8	0.3	0.3	0.2	0.9
Liver weight, right	0.7	1.2	1.7	-1.3	0.8	1.1	0.9	1.2
Locomotor activity	0.4	0.6	0.8	-0.7	-0.5	-0.9	-0.7	0.8
Locomotor testing distance	0.3	0.6	1.1	-1.0	-0.6	-0.7	-0.7	0.7
Locomotor testing rearing	0.3	0.7	1.3	-0.7	-0.6	-0.8	-1.1	0.8
Locomotion in novel chamber	1.4	1.8	2.9	-0.8	1.7	1.6	0.6	1.6
Locomotion in novel chamber post-restriction	0.1	0.2	0.5	0.2	0.2	0.4	0.0	0.7
Fecal boli incidents, locomotor time 1	0.4	0.6	1.7	0.9	0.1	-0.3	-1.3	0.5
Change in fecal boli incidents, locomotor task	2.4	2.4	4.1	-1.1	1.2	1.9	2.0	1.2
Time >=10cm from walls, locomotor time 1	1.6	1.7	2.7	-0.6	1.7	1.6	1.1	1.2
Bouts of movement, locomotor time 1	4.7	5.3	9.0	2.0	-2.1	-2.9	-3.0	-0.8
Total resting periods, locomotor time 1	3.1	3.4	6.1	1.7	-1.5	-2.4	-2.5	-0.5
Rest time, locomotor task time 1	0.4	0.5	1.5	-0.0	0.8	0.5	-0.1	1.2
Distance moved, locomotor task time 1	0.2	0.3	0.6	-0.2	0.0	0.8	0.6	-0.6
Vertical activity count, locomotor time 1	0.4	1.0	2.1	-1.1	0.4	0.9	1.5	0.8
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.6	0.1	0.3	0.2	-0.1	0.8
Bouts of movement, locomotor time 2	3.2	5.1	6.8	1.4	-2.5	-2.3	-2.6	-2.4
Total resting periods, locomotor time 2	2.5	4.4	6.0	1.1	-2.3	-2.2	-2.4	-2.2
Rest time, locomotor task time 2	0.2	0.2	0.5	-0.4	0.4	0.4	0.1	0.7
Distance moved, locomotor task time 2	0.0	0.1	0.2	0.4	-0.2	-0.0	-0.2	0.1
Vertical activity count, locomotor time 2	0.1	0.2	0.4	-0.1	-0.5	-0.1	0.3	0.7
Light reinforcement 1	0.1	0.3	0.6	-0.4	0.0	-0.4	-0.7	0.6
Light reinforcement 2	1.4	2.2	4.7	-1.0	2.2	1.4	1.4	1.1
Bone: marrow area	3.3	7.2	10.5	-1.7	3.1	3.2	3.1	1.7
Bone: maximum diameter	0.6	1.0	2.1	-0.8	1.4	0.9	1.2	0.4
Bone: maximum force	0.3	0.5	1.2	-0.2	0.6	0.4	0.8	-1.1
Bone: maximum moment	0.2	0.4	1.2	-0.2	0.5	0.2	0.6	-1.1
Mean time between licks in bursts	0.5	1.2	2.3	-0.8	-1.3	-1.1	-0.2	-1.5
Mean num. licks in bursts	0.6	0.9	1.7	0.1	-1.3	-1.2	-1.1	-0.1
Cd content in liver	0.5	0.6	1.4	0.0	0.4	1.2	0.3	1.1
Co content in liver	0.2	0.2	0.5	-0.4	-0.2	-0.5	-0.4	0.7
Cu content in liver	0.1	0.1	0.3	-0.6	0.1	-0.4	0.4	0.2
Fe content in liver	0.1	0.1	0.3	0.3	0.1	0.3	0.5	-0.0
K content in liver	0.3	0.3	0.8	-0.9	0.4	0.1	0.6	0.0
Mg content in liver	0.1	0.1	0.6	-0.8	0.1	0.0	-0.0	0.0
Mn content in liver	0.5	0.5	1.8	-0.1	-0.7	-0.6	-0.1	-1.3
Na content in liver	0.2	0.2	0.5	-0.1	-0.5	-0.4	-0.7	0.0
Rb content in liver	0.8	0.9	2.0	-1.4	0.8	0.3	0.4	1.3
Se content in liver	0.2	0.2	0.7	0.0	0.3	0.4	0.8	-0.2
Sr content in liver	3.9	3.4	6.3	2.0	-1.9	-1.3	-1.0	-2.5
Zn content in liver	1.6	1.7	3.0	0.1	-1.4	-1.7	-0.9	-1.7
Bone: minimum diameter	2.6	4.7	8.3	-2.9	2.4	1.8	2.1	1.3
Time in familiar zone, hab. session 1	0.3	0.3	0.9	-0.9	0.1	-0.7	-0.4	0.0
Time in novel zone, hab. session 1	0.4	0.4	0.9	0.6	0.2	0.9	0.1	1.0
Total zone transitions, hab. session 1	0.4	0.5	0.8	0.5	-0.9	-0.8	-0.7	-0.7
Total locomotion distance, hab. session 1	0.1	0.1	0.4	0.1	-0.0	0.4	0.3	-0.6
Locomotion velocity, hab. session 1	0.3	0.4	1.3	0.5	-0.6	-0.3	-0.2	-1.1
Time in familiar zone, hab. session 2	0.3	0.3	1.2	0.3	0.0	0.0	-0.4	1.1
Time in novel zone, hab. session 2	0.3	0.3	0.9	-0.4	-0.4	-0.4	-0.1	-0.9
Total zone transitions, hab. session 2	0.8	1.0	1.9	-0.4	-1.1	-1.4	-0.9	-0.9
Total locomotion distance, hab. session 2	0.3	0.4	0.6	-0.6	-0.6	-0.7	-0.3	-0.8
Locomotion velocity, hab. session 2	0.2	0.2	0.6	-0.8	-0.3	-0.4	-0.0	-0.6
Novel to familiar place preference ratio	0.4	0.4	1.4	0.4	-0.2	0.1	0.6	-1.2
Novelty place preference	0.3	0.3	0.9	0.4	0.0	0.3	0.8	-0.9
Time in novel zone, NPP test	0.5	0.5	1.5	0.8	-0.2	0.3	0.5	-1.2
Total zone transitions, NPP test	1.2	1.7	2.7	0.4	-1.6	-1.6	-1.2	-1.2
Total locomotion distance, NPP test	0.3	0.5	0.9	-0.8	-0.7	-0.9	-0.4	-0.5
Locomotion velocity, NPP test	0.4	0.5	1.5	-1.2	-0.5	-0.9	-0.2	-0.1
Intraocular pressure	0.1	0.2	0.4	0.5	-0.6	-0.5	-0.3	-0.1
Delta distance traveled before/after self-admin	0.4	0.4	0.8	-0.8	-0.9	-0.7	0.4	-0.1
Delta ambulatory time before/after self-admin	0.2	0.2	0.7	-0.2	-0.8	-0.6	0.2	0.3
Parametrial fat weight	6.1	14.4	22.5	-2.9	4.7	4.0	4.5	2.3
Pavlov. Cond. lever latency	0.3	0.3	1.3	1.1	-0.1	0.5	0.2	0.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	0.4	0.2	0.0	-0.4	-0.6
Pavlov. Cond. change in total contacts	0.3	0.3	0.8	-0.9	0.0	-0.7	-0.5	-0.1
Pavlov. Cond. index score	0.1	0.2	0.5	-0.1	0.0	-0.5	-0.7	-0.3
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.3	0.2	-0.3	-0.4	-0.0
Pavlov. Cond. lever contacts	0.3	0.3	1.5	-1.2	0.4	-0.2	-0.0	0.1
Pavlov. Cond. magazine entry number	0.3	0.4	0.6	-0.7	0.3	0.5	0.7	0.6
Pavlov. Cond. intertrial magazine entries	1.1	1.3	3.4	-0.9	-0.9	-1.8	-1.4	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	-0.3	-0.1	-0.7	-0.7	-0.4
Pavlov. Cond. response bias	0.2	0.3	0.5	-0.2	-0.1	-0.7	-0.6	-0.6
Pavlov. Cond. lever latency	0.3	0.4	1.3	-0.3	0.2	0.5	0.6	1.1
Pavlov. Cond. magazine entry latency	2.9	3.5	6.6	1.7	-1.5	-1.8	-1.6	-2.6
Pavlov. Cond. change in total contacts	0.7	1.1	1.6	1.0	-0.5	-1.0	-1.3	-1.2
Pavlov. Cond. index score	1.4	1.9	4.0	1.6	-0.7	-1.0	-1.2	-2.0
Pavlov. Cond. latency score	1.2	1.6	3.8	1.5	-0.5	-0.8	-1.0	-1.9
Pavlov. Cond. lever contacts	0.5	0.7	1.4	0.6	-0.4	-0.8	-1.0	-1.2
Pavlov. Cond. magazine entry number	4.4	5.4	10.6	-2.7	1.8	1.8	1.7	3.3
Pavlov. Cond. intertrial magazine entries	0.4	0.6	2.1	0.0	0.5	0.8	-0.0	1.5
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.3	4.4	1.8	-0.8	-1.1	-1.3	-2.1
Pavlov. Cond. response bias	1.0	1.3	3.4	0.8	-0.7	-1.1	-0.9	-1.9
Time in closed arm before self-admin	0.7	0.9	1.9	-0.1	1.4	1.2	0.3	1.1
Time in closed arm after self-admin	0.3	0.3	0.8	-0.2	0.7	0.3	0.0	0.9
Time in open arm before self-admin	0.4	0.4	0.9	-0.9	-0.4	-0.2	0.8	0.5
Time in open arm after self-admin	0.6	0.7	1.3	-0.3	-1.2	-1.2	-0.1	-0.8
Bone: periosteal estimation	1.4	3.0	4.8	-1.6	2.2	1.7	1.9	1.0
Bone: periosteal perimeter	0.5	0.9	1.7	-0.7	1.3	1.1	0.8	0.8
Bone: post-yield work	3.5	5.1	8.5	-1.3	2.9	2.8	2.6	1.0
Progressive ratio test 1 active lever presses	0.6	0.8	1.5	-0.7	0.9	0.9	1.2	0.2
Progressive ratio test 1 breakpoint	0.6	0.7	1.4	-0.6	0.9	0.9	1.2	0.2
Progressive ratio test 1 inactive lever presses	0.3	0.5	2.4	0.3	0.1	0.0	-0.2	-1.5
Progressive ratio test 2 active lever presses	1.5	1.8	3.4	-1.2	1.8	1.4	1.2	0.8
Progressive ratio test 2 breakpoint	1.6	1.9	3.6	-1.3	1.9	1.4	1.2	0.7
Progressive ratio test 2 inactive lever presses	0.9	1.5	3.6	-1.4	1.9	1.1	0.8	0.5
Incentive Sensitization - Responses	0.2	0.3	0.6	0.1	0.7	0.7	0.1	-0.6
Incentive Sensitization - Breakpoint	0.3	0.4	1.0	-0.0	1.0	0.9	0.3	-0.5
Sum of active levers in priming session hrs 5-6	0.9	0.9	2.3	-0.1	-1.0	-1.5	-1.0	-0.3
Progressive ratio	0.7	1.2	1.7	-1.0	1.2	1.3	1.3	-0.1
Food seeking constrained by brief footshock	0.3	0.3	1.4	-1.2	-0.2	-0.1	0.5	-0.0
Seeking ratio, punishment vs. effort	0.3	0.5	1.1	-0.3	-1.0	-1.0	-0.4	-0.4
Retroperitoneal fat weight	3.5	15.1	21.6	-3.5	4.6	4.1	3.8	3.2
Reaction time number correct	2.0	3.9	17.0	4.1	-0.8	0.1	-1.3	-0.3
Reaction time mean minus median	0.6	1.5	4.1	2.0	-1.0	-0.4	-1.4	-0.6
Reaction time mean minus median AUC	1.0	2.7	5.5	2.4	-1.6	-0.9	-2.0	-0.5
Reaction time num false alarms	0.1	0.2	0.5	-0.4	-0.3	-0.7	-0.0	0.3
Reaction time num false alarms AUC	0.2	0.4	1.2	-0.2	-0.7	-1.1	-0.2	0.0
Reaction time trials correct on left	2.0	3.9	17.0	4.1	-0.8	0.1	-1.3	-0.3
Reaction time trials on left	2.2	4.2	18.1	4.3	-0.9	0.1	-1.4	-0.3
Reaction time mean	0.3	0.5	0.8	0.8	-0.9	-0.4	-0.8	-0.3
Reaction time mean AUC	0.1	0.2	0.5	0.4	-0.7	-0.3	-0.7	-0.1
Median of all reaction times	0.1	0.1	0.3	0.2	-0.5	-0.3	-0.3	-0.4
Reaction time omissions	0.7	1.1	3.1	1.8	-0.9	-0.6	-0.9	-0.4
Reaction time false alarm rate	1.1	1.4	6.0	-2.4	0.1	-0.8	0.7	0.3
Reaction time premature initiation rate	0.5	0.7	2.0	-0.5	0.6	0.4	0.8	-1.4
Reaction time premature initiations	0.7	1.3	3.6	1.9	-0.4	-0.0	-0.4	-1.5
Std. dev. reaction times	0.6	1.1	1.9	1.3	-1.1	-0.7	-1.4	-0.1
Reaction time trials completed	2.2	4.2	18.1	4.3	-0.9	0.1	-1.4	-0.3
Reaction time trials AUC	2.0	3.9	16.7	4.1	-0.8	0.1	-1.3	-0.3
Run reversals in cocaine runway, females	0.7	0.7	1.4	-0.4	0.8	1.1	1.2	-0.3
Run reversals in cocaine runway, males	1.3	1.3	3.9	-2.0	0.6	0.0	0.9	1.3
Latency to leave start box in cocaine runway	2.8	3.2	5.1	-1.2	2.3	2.1	1.9	1.2
Latency to leave start box in cocaine runway, F	0.4	0.5	1.0	-0.5	1.0	0.8	0.6	0.4
Latency to leave start box in cocaine runway, M	3.4	3.2	4.5	-1.0	2.1	2.1	1.9	1.5
Std. dev. time between licks in bursts	0.5	0.6	2.6	-1.6	0.2	-0.1	0.6	0.3
Total sessions with >9 infusions	0.4	0.5	1.2	0.0	0.5	1.1	1.1	0.1
Short access day 1 total inactive lever presses	0.4	0.5	0.8	-0.8	0.7	0.7	0.9	-0.1
Short access day 10 total inactive lever presses	0.1	0.2	0.6	-0.0	-0.8	-0.7	-0.4	-0.1
Short access day 1 total infusions	0.7	0.9	1.4	-0.7	1.0	1.2	1.1	0.7
Short access day 10 total infusions	2.4	3.1	6.7	-1.2	1.7	2.0	2.6	-0.1
Short access total infusions	1.5	1.9	4.0	-0.8	1.4	1.8	2.0	0.1
Short access day 1 locomotion	0.5	0.6	1.2	-1.1	0.7	0.2	1.0	0.5
Short access day 10 total locomotion	0.6	1.1	2.0	-0.5	0.9	1.3	1.4	-0.9
Short access total locomotion	0.9	1.0	2.1	-0.8	1.0	1.1	1.4	-0.4
One hour access (0.3 mA shock)	2.7	3.1	4.8	-2.2	2.1	1.4	1.9	0.8
Compulsive drug intake	2.6	3.1	4.6	2.0	-2.1	-1.5	-1.7	-1.3
One hour access (shock baseline)	4.7	7.1	10.3	-3.0	3.2	2.2	2.6	2.2
Social response proportion	0.4	0.5	0.9	0.1	0.8	0.5	0.7	1.0
Social responses	0.3	0.4	0.8	-0.2	-0.3	-0.9	-0.4	0.8
Social time	1.0	1.4	2.3	1.2	-1.5	-1.3	-1.3	-0.0
Soleus weight	0.9	2.6	8.3	-1.7	1.2	0.5	0.5	2.9
Bone: stiffness	0.2	0.3	0.9	-0.5	0.9	0.3	0.6	0.0
Tibialis anterior weight	5.1	17.3	30.4	4.8	-4.0	-3.2	-2.6	-5.5
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.6	0.2	0.9	1.3	1.2	-0.2
Time to tail flick, vehicle, after self-admin	0.5	0.7	1.6	1.3	-0.0	0.8	0.3	-1.0
Time to tail flick, test, before self-admin	0.6	0.6	1.2	-0.4	1.1	1.0	0.7	-0.2
Time to tail flick, test, after self-admin	0.2	0.2	0.7	0.0	0.0	-0.3	-0.8	0.4
Delta time to tail flick, vehicle, before/after SA	0.8	0.7	1.0	0.9	-0.9	-0.7	-1.0	-0.8
Delta time to tail flick, test, before/after SA	1.7	1.7	4.1	-0.0	-1.4	-2.0	-1.6	0.0
Tibia length	0.2	0.6	2.1	1.4	0.1	0.0	-0.2	-0.8
Ambulatory time before self-admin	0.2	0.3	1.0	0.5	0.1	-0.3	-1.0	-0.5
Ambulatory time after self-admin	0.1	0.1	0.1	-0.4	0.2	-0.2	-0.2	0.1
Bone: tissue strength	0.5	0.5	1.6	-1.3	0.3	-0.0	0.2	1.0
Total heroin consumption	5.4	6.4	7.4	2.5	-2.7	-2.6	-2.5	-2.3
Bone: trabecular number	0.3	0.4	1.1	-0.4	0.4	0.4	0.7	-1.0
Bone: trabecular spacing	1.0	1.3	2.4	0.4	-1.4	-1.4	-1.6	0.5
Bone: trabecular thickness	0.5	0.6	1.5	-0.6	1.2	0.6	0.5	0.7
Bone: trabecular tissue density	1.1	1.7	5.1	-1.4	1.0	0.5	0.3	2.3
Water consumed over 24 hours	0.1	0.2	0.6	0.1	-0.1	-0.8	-0.3	-0.3
Number of responses in last shaping day	0.6	0.6	1.2	0.4	-1.1	-0.9	-0.3	-1.0