Prss52

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Prss52	0.15	0.08	8.4e-07	0.09	0.09	0.09	0.05	2.5e-05	1.4e-05	1.1e-05	9.2e-04
2	PL	gene expression	Prss52	0.09	0.05	2.6e-09	0.06	0.08	0.06	0.08	1.8e-07	7.9e-09	7.3e-07	8.8e-09
3	Liver	gene expression	Prss52	0.04	0.03	6.9e-04	0.02	0.02	0.01	0.02	1.2e-03	4.3e-03	1.3e-02	4.2e-03
4	NAcc	gene expression	Prss52	0.06	0.04	4.3e-06	0.02	0.03	0.04	0.03	8.0e-04	6.8e-05	4.6e-05	1.0e-04
5	Brain	gene expression	Prss52	0.14	0.07	9.4e-13	0.16	0.15	0.12	0.15	8.1e-15	1.9e-13	3.9e-11	4.4e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.3	0.4	1.3	-0.4	0.3	-0.8	-0.3	-1.1
Area under the delay curve	4.5	4.8	6.5	2.4	-1.8	2.6	1.4	2.5
BMI with tail	1.5	4.7	6.3	2.4	-1.9	2.5	1.5	2.3
BMI without tail	0.2	0.4	0.6	-0.4	0.8	-0.7	-0.7	-0.7
Body weight	1.9	7.9	10.0	3.2	-2.8	2.8	2.6	2.7
Weight adjusted by age	1.8	2.0	3.1	1.5	-1.6	1.2	1.8	0.7
Bone surface	0.1	0.2	0.6	-0.1	0.1	-0.5	-0.1	-0.8
Bone volume	0.0	0.1	0.2	0.1	0.0	-0.1	-0.2	-0.5
Breakpoint value in progressive ratio session	0.2	0.2	0.7	0.3	-0.1	0.8	-0.1	0.5
Number of licking bursts	0.2	0.3	0.6	0.3	-0.3	0.7	0.3	0.8
Context. condit. distance diff. score	2.2	2.7	5.3	-1.4	1.9	-0.8	-2.3	-1.2
Locomotion velocity, session 1	0.2	0.3	0.4	0.7	-0.5	0.4	0.4	0.4
Locomotion distance, session 1	0.0	0.1	0.1	0.3	-0.3	-0.2	0.2	-0.1
Locomotion velocity, session 2	0.4	0.4	0.9	0.9	-0.7	0.6	0.5	0.4
Locomotion distance, session 2	0.1	0.1	0.2	0.3	-0.3	-0.3	0.3	-0.4
Locomotion velocity, session 3	1.1	1.3	1.7	1.3	-1.2	0.8	1.3	1.0
Locomotion distance, session 3	0.6	0.6	1.0	1.0	-0.7	0.6	0.7	0.9
Stereotopy head waving bouts, day 3	0.3	0.4	0.9	-0.8	0.1	-0.9	0.2	-0.4
Stereotopy head waving duration, day 3	0.6	0.7	1.6	0.3	-1.1	0.3	1.3	0.7
Locomotion velocity, session 7	1.7	1.8	3.4	-0.5	1.6	-1.2	-1.8	-1.3
Locomotion distance, session 7	2.9	3.7	5.2	-1.7	2.1	-1.5	-2.3	-1.9
Stereotopy head waving bouts, day 7	2.0	2.3	2.7	1.5	-1.7	1.4	1.6	1.4
Stereotopy head waving duration, day 7	2.8	3.4	4.3	1.8	-2.1	1.4	2.1	1.8
Locomotion velocity, session 8	0.1	0.1	0.3	0.4	-0.1	0.5	-0.1	0.2
Locomotion distance, session 8	0.4	0.7	1.3	-0.5	0.9	-0.5	-1.1	-0.8
Degree of sensitization distance	7.6	7.6	9.6	-2.7	3.0	-2.2	-3.1	-2.7
Degree of sensitization stereotypy	1.7	1.9	2.3	1.5	-1.4	1.4	1.1	1.4
Conditioned locomotion	0.5	0.6	1.2	-0.8	0.9	-0.3	-1.1	-0.7
Cocaine response after cond. corrected	0.6	0.7	1.7	-0.8	1.1	0.0	-1.3	0.0
Cocaine response after cond. not corrected	0.4	0.4	0.9	-0.5	0.8	0.1	-1.0	0.2
Cocaine response before conditioning	0.5	0.6	1.1	0.8	-0.9	0.5	1.0	0.4
Saline control response	0.1	0.1	0.3	-0.5	-0.1	-0.5	0.3	0.1
Bone: connectivity density	1.3	2.0	3.8	-1.3	0.8	-1.8	-0.6	-2.0
Bone: cortical apparent density	0.0	0.1	0.2	0.1	0.3	0.1	-0.2	0.4
Bone: cortical area	0.7	1.1	1.7	1.2	-0.7	1.3	0.4	1.3
Bone: cortical porosity	2.8	3.0	4.0	1.5	-1.8	2.0	1.7	1.6
Bone: cortical porosity	1.8	1.9	2.5	1.1	-1.5	1.6	1.4	1.3
Bone: cortical thickness	1.4	2.4	4.0	1.8	-1.1	1.6	0.9	2.0
Bone: cortical thickness	0.6	0.8	1.5	1.1	0.1	0.9	-0.4	1.2
Bone: cortical tissue density	0.0	0.1	0.2	0.0	0.3	0.0	-0.2	0.4
Condit. Reinf. active minus inactive responses	0.6	0.7	1.3	1.1	-0.9	0.5	0.9	0.4
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.1	-0.2	0.0	-0.4	0.1	-0.2
Condit. Reinf. active responses	0.8	0.9	1.7	1.3	-1.0	0.9	0.9	0.6
Condit. Reinf. inactive responses	0.3	0.4	0.6	0.7	-0.6	0.7	0.4	0.4
Incentive salience index mean	2.9	3.5	5.2	2.3	-1.9	1.9	1.8	1.4
Condit. Reinf. lever presses	3.9	5.3	7.3	2.7	-2.2	2.7	2.0	1.8
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	-0.4	0.6	-0.7	-0.5	-0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.1	0.2	-0.4	-0.2	-0.2
Condit. Reinf. active responses	0.3	0.4	0.5	-0.6	0.7	-0.6	-0.7	-0.7
Condit. Reinf. inactive responses	1.1	1.4	1.5	-1.2	1.2	-1.0	-1.2	-1.2
Condit. Reinf. lever presses	0.3	0.4	1.1	0.6	-0.8	0.1	1.0	-0.0
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.3	-0.3
Conditioned reinforcement - actives	9.5	9.5	10.7	-3.0	3.3	-2.9	-3.1	-3.1
Conditioned reinforcement - inactives	1.4	1.6	2.0	-1.4	1.1	-1.4	-0.9	-1.3
Conditioned locomotion	3.3	3.9	5.8	-1.8	2.4	-1.7	-2.2	-1.7
Patch foraging indifference point 0 sec	0.2	0.3	0.6	0.4	-0.7	-0.1	0.8	0.1
Patch foraging indifference point AUC	0.5	0.5	1.1	-0.3	1.0	-0.8	-0.9	-0.3
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	0.1	-0.1	0.5	-0.1	0.3
Delay disc. indifference point, 16s delay	2.1	2.1	3.3	1.5	-1.2	1.6	0.9	1.8
Delay disc. indifference point, 2s delay	0.5	0.5	0.8	0.7	-0.6	0.8	0.5	0.9
Delay disc. indifference point, 24s delay	2.5	2.4	3.9	2.0	-1.1	1.8	0.7	1.9
Delay disc. indifference point, 4s delay	4.6	4.9	6.4	2.2	-2.1	2.5	1.7	2.5
Delay disc. indifference point, 8s delay	5.6	5.8	8.4	2.6	-2.0	2.9	1.6	2.7
Indifference point function ln k	1.2	1.7	2.3	1.1	-1.5	1.5	1.3	1.0
Indifference point function log k	1.2	1.7	2.3	1.1	-1.5	1.5	1.3	1.0
Patch foraging total patch changes 0 sec	0.4	0.6	1.2	0.7	-1.0	0.3	1.1	0.5
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	0.5	-0.2	-0.2	0.3	0.2
Patch foraging total patch changes 18 sec	0.8	1.0	1.9	-0.6	1.2	-1.4	-1.0	-0.7
Patch foraging total patch changes 24 sec	0.0	0.1	0.1	0.0	-0.1	-0.4	0.3	0.0
Patch foraging total patch changes 6 sec	0.0	0.1	0.2	0.3	0.1	-0.4	0.1	0.0
Patch foraging time to switch 0 sec	0.1	0.1	0.1	-0.3	0.3	-0.2	-0.4	-0.3
Patch foraging water rate 0 sec	1.0	1.6	2.0	1.4	-1.3	1.0	1.4	1.2
Patch foraging water rate 12 sec	0.5	0.8	1.3	0.7	-0.9	1.1	0.8	0.9
Patch foraging water rate 18 sec	3.5	4.7	5.3	2.3	-2.1	2.3	2.1	2.0
Patch foraging water rate 24 sec	0.1	0.1	0.5	0.4	-0.0	0.7	-0.3	0.1
Patch foraging water rate 6 sec	0.9	1.4	1.9	0.9	-1.3	0.8	1.4	1.3
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.3	0.1	-0.1	-0.2	-0.2
Distance traveled before self-admin	0.1	0.2	0.5	-0.2	0.2	-0.7	-0.1	-0.4
Distance traveled after self-admin	0.1	0.1	0.1	-0.2	0.4	-0.2	-0.3	-0.2
Extensor digitorum longus weight	7.0	27.7	32.6	5.4	-5.0	5.5	4.6	5.7
Bone: elastic displacement	0.3	0.3	0.8	-0.9	0.3	-0.8	-0.1	-0.3
Bone: elastic work	0.4	0.5	1.0	0.5	-0.9	0.1	1.0	0.7
Bone: endosteal estimation	0.0	0.1	0.3	-0.0	0.1	-0.1	-0.2	-0.5
Bone: endosteal perimeter	0.3	0.6	1.4	-0.7	0.6	-0.6	-0.6	-1.2
Epididymis fat weight	0.1	0.1	0.3	-0.1	0.5	-0.3	-0.5	-0.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	-0.1	0.3	-0.1	-0.4	-0.5
Delta time in open arm before/after self-admin	0.1	0.1	0.4	-0.3	0.3	-0.6	-0.1	-0.0
Diff in mean of infusions in LGA sessions	3.3	3.7	5.0	2.2	-1.9	1.5	2.2	1.6
Delay discount exponential model param	5.1	5.4	7.4	-2.5	2.0	-2.7	-1.5	-2.7
Extinction: sum of active levers before priming	0.3	0.3	0.5	-0.5	0.7	-0.0	-0.7	-0.5
Active lever presses in extinction session 6	0.4	0.4	0.6	-0.4	0.7	-0.6	-0.7	-0.8
Bone: final force	1.1	1.8	3.4	1.8	-1.0	1.4	0.8	1.4
Bone: final moment	1.1	1.8	3.0	1.7	-1.2	1.4	1.0	1.3
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.1	-0.4	0.2	0.4	0.1
Glucose	0.0	0.0	0.1	0.2	0.1	0.2	-0.2	0.3
Heart weight	0.1	0.1	0.5	0.1	0.4	-0.3	-0.1	-0.7
Delay discount hyperbolic model param	5.3	5.6	7.6	-2.4	2.1	-2.8	-1.7	-2.7
Intermittent access intake day 1-15 change	0.9	0.9	1.5	-0.8	0.9	-1.2	-0.9	-1.0
Intermittent access intake escalation	1.2	1.2	1.6	-1.0	1.1	-1.3	-1.1	-1.0
Intermittent access intake escalation 2	0.7	0.6	0.9	-0.9	0.8	-0.9	-0.6	-0.7
Intermitt. access day 1 inactive lever presses	0.7	0.8	1.3	-0.8	0.7	-1.1	-0.6	-1.0
Intermitt. access day 15 inactive lever presses	0.2	0.3	0.9	0.0	-0.7	0.1	0.9	0.0
Intermitt. access escalation Index	0.8	0.7	1.3	-0.9	0.9	-0.6	-1.1	-0.5
Intermittent access day 1 total infusions	0.5	0.5	0.9	-0.9	0.9	-0.3	-0.9	-0.3
Intermittent access day 15 total infusions	2.5	2.8	3.4	-1.8	1.8	-1.6	-1.9	-1.3
Intermittent access terminal intake (last 3 days)	1.8	2.0	2.6	-1.6	1.5	-1.3	-1.6	-0.9
Intermittent access total infusions	2.1	2.3	3.5	-1.6	1.7	-1.2	-1.9	-1.0
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.0	-0.1	0.5	0.0	0.5
Intermittent access day 15 total locomotion	0.8	0.9	1.2	-1.1	1.0	-1.0	-0.8	-0.6
Intermittent access total locomotion	0.1	0.1	0.2	-0.5	0.3	-0.1	-0.3	0.1
Intermittent access standard deviation	0.7	0.8	1.3	-1.2	0.7	-0.8	-0.8	-0.8
Left kidney weight	1.6	4.4	8.0	2.8	-2.2	1.6	2.2	1.4
Right kidney weight	2.0	5.5	8.8	3.0	-2.4	1.8	2.7	1.5
Cocaine induced anxiety	0.2	0.3	0.5	0.5	-0.6	0.4	0.7	0.2
Post-drug Anxiety	0.8	0.9	1.9	0.9	-1.2	0.5	1.4	0.2
Baseline Anxiety	0.1	0.1	0.2	0.1	-0.5	0.3	0.2	0.4
Tail length	0.6	1.7	2.7	-1.3	1.1	-1.6	-0.8	-1.6
Length with tail	0.3	1.2	2.0	1.2	-1.3	0.6	1.4	0.6
Length without tail	4.2	9.3	10.2	3.2	-3.2	2.9	3.0	2.9
Times rat made contact with spout	0.0	0.0	0.1	0.4	-0.1	0.2	-0.1	-0.2
Lifetime Intake	2.5	2.9	4.1	-1.8	1.9	-1.4	-2.0	-1.2
Liver weight, left	2.2	3.6	4.5	2.1	-1.8	1.9	1.7	1.9
Liver weight, right	1.2	1.9	2.8	1.3	-1.4	1.3	1.3	1.7
Locomotor activity	3.2	5.1	6.4	2.5	-2.5	1.8	2.5	1.8
Locomotor testing distance	0.3	0.5	1.1	0.7	-1.0	-0.1	1.1	0.2
Locomotor testing rearing	0.4	0.6	1.0	-0.1	-0.7	-1.0	1.0	-0.7
Locomotion in novel chamber	0.7	0.8	1.3	1.2	-0.9	0.6	0.9	0.7
Locomotion in novel chamber post-restriction	0.2	0.3	1.2	1.1	-0.2	0.0	0.2	0.1
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	0.1	0.2	0.4	-0.4	-0.1
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	0.3	-0.4	-0.2	0.5	-0.1
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.4	0.4	-0.4	-0.6	0.6	-0.3
Bouts of movement, locomotor time 1	0.1	0.1	0.3	0.5	-0.3	0.5	-0.3	0.3
Total resting periods, locomotor time 1	0.1	0.1	0.5	0.3	0.2	0.2	-0.7	0.1
Rest time, locomotor task time 1	0.2	0.2	0.6	0.8	-0.1	0.4	-0.2	0.3
Distance moved, locomotor task time 1	0.5	0.5	1.1	-1.0	0.5	-0.9	-0.2	-0.6
Vertical activity count, locomotor time 1	0.2	0.2	0.5	-0.7	-0.3	-0.1	0.7	0.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.1	-0.2	-0.4	0.3	-0.3
Bouts of movement, locomotor time 2	1.7	1.8	2.7	1.6	-1.2	1.4	0.7	1.6
Total resting periods, locomotor time 2	2.4	2.6	3.7	1.9	-1.4	1.7	0.9	1.9
Rest time, locomotor task time 2	1.1	1.2	2.5	1.6	-0.8	1.1	0.4	1.3
Distance moved, locomotor task time 2	0.5	0.6	1.6	-1.3	0.5	-0.7	-0.4	-0.6
Vertical activity count, locomotor time 2	0.3	0.3	1.3	-1.2	0.3	-0.0	-0.0	-0.1
Light reinforcement 1	0.0	0.0	0.1	0.2	-0.3	0.3	-0.0	0.2
Light reinforcement 2	0.5	0.6	1.0	-0.9	0.9	-0.6	-1.0	-0.6
Bone: marrow area	0.0	0.1	0.3	-0.1	0.2	-0.1	-0.3	-0.6
Bone: maximum diameter	0.1	0.2	0.5	0.5	-0.1	0.7	-0.1	0.6
Bone: maximum force	1.2	2.1	3.6	1.9	-1.1	1.6	0.9	1.6
Bone: maximum moment	1.2	2.1	3.2	1.8	-1.3	1.5	1.1	1.5
Mean time between licks in bursts	3.4	4.8	6.4	-2.4	2.0	-2.2	-1.7	-2.5
Mean num. licks in bursts	0.3	0.4	0.9	-0.2	0.4	-0.7	-0.5	-0.9
Cd content in liver	0.3	0.3	0.6	-0.7	0.3	-0.8	-0.2	-0.7
Co content in liver	0.7	0.8	2.4	0.7	-0.4	1.6	-0.1	0.9
Cu content in liver	0.7	0.8	1.0	0.9	-1.0	1.0	0.9	0.6
Fe content in liver	0.5	0.7	1.4	-0.7	0.5	-1.2	-0.3	-1.0
K content in liver	0.5	0.5	0.8	-0.9	0.8	0.2	-0.8	-0.5
Mg content in liver	1.1	1.1	1.8	-1.3	1.1	-0.6	-1.0	-1.0
Mn content in liver	1.5	1.7	2.4	-1.5	1.5	-0.4	-1.5	-1.2
Na content in liver	8.0	8.5	11.7	2.7	-3.2	2.5	3.4	2.6
Rb content in liver	1.4	1.7	2.5	-1.6	1.2	-1.3	-1.0	-1.4
Se content in liver	0.1	0.1	0.2	-0.3	-0.3	0.4	0.4	-0.1
Sr content in liver	1.4	1.3	2.2	-1.0	0.8	-1.5	-0.6	-1.5
Zn content in liver	2.8	3.0	4.2	1.4	-2.0	1.9	2.0	1.2
Bone: minimum diameter	0.3	0.6	1.0	1.0	-0.6	0.8	0.5	0.8
Time in familiar zone, hab. session 1	0.3	0.3	0.8	-0.4	0.8	-0.0	-0.9	-0.3
Time in novel zone, hab. session 1	1.2	1.1	1.6	1.0	-1.2	0.4	1.3	1.3
Total zone transitions, hab. session 1	0.3	0.4	0.8	0.9	-0.5	0.4	0.4	0.8
Total locomotion distance, hab. session 1	0.0	0.1	0.1	0.4	0.0	-0.4	0.0	0.2
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.5	-0.2	0.0	0.3	0.2
Time in familiar zone, hab. session 2	0.4	0.5	0.8	-0.8	0.7	-0.4	-0.9	-0.4
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.5	-0.4	0.1	0.5	0.2
Total zone transitions, hab. session 2	0.6	0.8	1.3	1.1	-0.9	1.2	0.7	0.7
Total locomotion distance, hab. session 2	0.3	0.4	0.8	0.9	-0.4	0.8	0.2	0.4
Locomotion velocity, hab. session 2	0.6	0.8	1.4	1.2	-0.8	1.2	0.6	0.7
Novel to familiar place preference ratio	0.3	0.3	0.7	-0.2	0.4	-0.8	-0.5	-0.6
Novelty place preference	0.2	0.2	0.5	-0.0	0.3	-0.7	-0.4	-0.6
Time in novel zone, NPP test	0.1	0.1	0.5	0.1	0.1	-0.7	-0.2	-0.4
Total zone transitions, NPP test	0.1	0.2	0.4	0.6	-0.3	0.6	0.1	0.0
Total locomotion distance, NPP test	0.7	1.0	2.0	-0.7	0.9	-0.8	-0.9	-1.4
Locomotion velocity, NPP test	0.8	1.1	2.1	-0.8	1.0	-0.8	-1.1	-1.4
Intraocular pressure	3.3	4.7	7.7	-2.4	1.7	-2.8	-1.3	-2.2
Delta distance traveled before/after self-admin	0.2	0.2	0.5	0.3	-0.3	0.7	0.3	0.5
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.1	0.1	0.3	-0.0	0.3
Parametrial fat weight	3.8	7.4	9.5	-2.7	3.1	-2.1	-3.1	-2.6
Pavlov. Cond. lever latency	1.7	2.2	4.8	-1.7	1.2	-2.2	-1.0	-0.9
Pavlov. Cond. magazine entry latency	1.0	1.3	1.7	1.3	-1.2	1.1	1.2	0.9
Pavlov. Cond. change in total contacts	4.1	4.4	6.0	2.5	-2.0	2.2	1.9	1.8
Pavlov. Cond. index score	4.4	5.6	7.9	2.7	-2.3	2.8	2.1	1.9
Pavlov. Cond. latency score	3.4	4.4	6.5	2.4	-2.0	2.5	1.8	1.6
Pavlov. Cond. lever contacts	3.0	3.5	5.8	2.2	-1.8	2.4	1.6	1.2
Pavlov. Cond. magazine entry number	2.5	3.1	3.6	-1.9	1.8	-1.9	-1.7	-1.5
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.3	-0.2	0.0	0.3	0.0
Pavlov. Cond. lever-magazine prob. diff.	5.3	6.5	8.9	2.9	-2.5	3.0	2.2	2.1
Pavlov. Cond. response bias	3.8	4.6	6.0	2.4	-2.1	2.4	2.0	1.8
Pavlov. Cond. lever latency	1.9	2.6	4.8	-1.5	1.9	-0.9	-2.2	-1.1
Pavlov. Cond. magazine entry latency	2.3	2.6	2.9	1.5	-1.7	1.5	1.7	1.6
Pavlov. Cond. change in total contacts	3.4	4.7	7.5	2.1	-2.4	1.3	2.7	2.1
Pavlov. Cond. index score	3.1	4.0	6.1	1.8	-2.3	1.5	2.5	1.8
Pavlov. Cond. latency score	3.1	3.8	5.9	1.8	-2.2	1.5	2.4	1.7
Pavlov. Cond. lever contacts	1.5	2.1	4.2	1.2	-1.8	0.7	2.1	0.9
Pavlov. Cond. magazine entry number	1.0	1.2	1.2	-1.1	1.1	-1.1	-1.1	-1.1
Pavlov. Cond. intertrial magazine entries	7.7	10.1	13.0	-3.1	3.0	-3.1	-3.0	-3.6
Pavlov. Cond. lever-magazine prob. diff.	3.1	3.9	5.7	1.8	-2.2	1.5	2.4	1.9
Pavlov. Cond. response bias	2.3	3.1	4.9	1.7	-2.1	1.2	2.2	1.5
Time in closed arm before self-admin	3.4	3.8	4.2	2.0	-2.1	1.8	1.9	2.0
Time in closed arm after self-admin	1.7	1.8	3.1	1.8	-1.3	1.5	0.9	1.1
Time in open arm before self-admin	1.2	1.3	2.2	-1.0	1.1	-1.1	-1.1	-1.5
Time in open arm after self-admin	1.0	1.1	1.9	-1.0	0.9	-1.4	-0.6	-1.1
Bone: periosteal estimation	0.1	0.1	0.3	0.5	-0.1	0.5	-0.1	0.2
Bone: periosteal perimeter	0.0	0.0	0.1	0.3	0.0	0.4	-0.2	-0.0
Bone: post-yield work	0.6	0.8	2.4	0.1	1.2	0.3	-1.6	0.2
Progressive ratio test 1 active lever presses	0.4	0.4	1.0	-0.5	0.8	-0.2	-1.0	-0.1
Progressive ratio test 1 breakpoint	0.4	0.4	1.1	-0.5	0.8	-0.2	-1.0	-0.0
Progressive ratio test 1 inactive lever presses	1.2	1.4	1.9	-1.4	1.1	-1.4	-0.9	-1.0
Progressive ratio test 2 active lever presses	3.6	3.9	4.5	-2.0	2.1	-1.9	-2.1	-1.7
Progressive ratio test 2 breakpoint	2.4	2.7	3.0	-1.7	1.7	-1.6	-1.7	-1.5
Progressive ratio test 2 inactive lever presses	1.8	2.1	2.7	-1.7	1.4	-1.4	-1.3	-1.5
Incentive Sensitization - Responses	3.0	3.1	4.5	-1.8	1.6	-2.1	-1.4	-1.8
Incentive Sensitization - Breakpoint	3.0	3.1	4.5	-1.8	1.5	-2.1	-1.3	-1.9
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.1	-0.8	1.0	-0.6	-1.0	-0.8
Progressive ratio	0.5	0.6	1.4	0.6	-0.9	0.5	1.2	0.6
Food seeking constrained by brief footshock	0.2	0.2	0.6	-0.4	0.7	-0.1	-0.8	-0.0
Seeking ratio, punishment vs. effort	0.2	0.3	0.9	-0.3	0.6	-0.1	-0.9	-0.1
Retroperitoneal fat weight	0.9	2.8	4.9	-1.3	2.0	-1.2	-2.2	-1.5
Reaction time number correct	0.3	0.4	0.8	-0.7	0.5	-0.6	-0.4	-0.9
Reaction time mean minus median	0.5	0.7	1.5	0.9	-0.8	0.5	1.2	0.3
Reaction time mean minus median AUC	0.2	0.3	0.9	0.6	-0.6	0.1	0.9	0.0
Reaction time num false alarms	0.8	1.1	1.6	1.2	-1.2	0.7	1.3	0.6
Reaction time num false alarms AUC	0.7	1.0	1.7	1.3	-1.1	0.6	1.2	0.5
Reaction time trials correct on left	0.3	0.4	0.8	-0.7	0.5	-0.6	-0.4	-0.9
Reaction time trials on left	0.4	0.6	1.1	-0.8	0.6	-0.7	-0.5	-1.0
Reaction time mean	0.1	0.1	0.3	-0.1	0.0	-0.1	0.3	-0.6
Reaction time mean AUC	0.1	0.1	0.5	0.1	-0.3	0.0	0.7	-0.3
Median of all reaction times	0.1	0.2	0.6	-0.5	0.3	-0.3	-0.0	-0.8
Reaction time omissions	2.5	3.4	6.3	-1.7	1.7	-1.9	-1.2	-2.5
Reaction time false alarm rate	1.0	1.4	2.3	1.5	-1.2	0.9	1.2	1.0
Reaction time premature initiation rate	0.2	0.3	0.6	0.8	-0.4	0.6	0.3	0.6
Reaction time premature initiations	0.0	0.0	0.1	0.3	0.0	0.2	-0.0	0.0
Std. dev. reaction times	0.1	0.1	0.2	0.1	0.0	-0.3	0.4	-0.5
Reaction time trials completed	0.4	0.6	1.1	-0.8	0.6	-0.7	-0.5	-1.0
Reaction time trials AUC	0.5	0.7	1.2	-0.9	0.7	-0.8	-0.5	-1.1
Run reversals in cocaine runway, females	0.1	0.1	0.2	-0.4	0.2	-0.5	-0.0	-0.3
Run reversals in cocaine runway, males	3.1	3.0	3.7	1.4	-1.8	1.7	1.7	1.9
Latency to leave start box in cocaine runway	1.1	1.2	1.6	-1.0	1.0	-1.3	-1.0	-1.2
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.3	0.1	-0.5	-0.1	-0.3
Latency to leave start box in cocaine runway, M	1.7	1.7	2.1	-1.5	1.1	-1.5	-0.9	-1.5
Std. dev. time between licks in bursts	1.2	1.4	2.1	-1.4	1.0	-1.2	-0.7	-1.5
Total sessions with >9 infusions	1.7	1.9	2.4	-1.5	1.4	-1.4	-1.3	-1.2
Short access day 1 total inactive lever presses	0.5	0.6	1.0	-0.7	0.8	-0.8	-1.0	-0.5
Short access day 10 total inactive lever presses	0.8	0.9	1.0	-0.9	0.9	-1.0	-0.9	-1.0
Short access day 1 total infusions	3.7	3.9	5.6	-2.4	2.1	-1.5	-2.2	-1.6
Short access day 10 total infusions	0.1	0.1	0.3	-0.4	0.3	0.1	-0.5	0.3
Short access total infusions	0.9	1.0	1.7	-1.3	1.0	-0.6	-1.2	-0.6
Short access day 1 locomotion	0.3	0.3	0.6	-0.6	0.6	-0.5	-0.3	-0.8
Short access day 10 total locomotion	0.7	0.8	1.3	0.5	-1.0	1.1	1.0	0.8
Short access total locomotion	0.1	0.1	0.3	-0.0	-0.4	0.4	0.6	0.2
One hour access (0.3 mA shock)	1.3	1.6	2.7	-1.3	1.4	-0.9	-1.6	-0.8
Compulsive drug intake	0.1	0.1	0.2	0.5	-0.2	0.3	-0.0	0.3
One hour access (shock baseline)	2.2	2.6	3.1	-1.7	1.8	-1.4	-1.8	-1.3
Social response proportion	3.1	3.4	5.2	-1.5	2.0	-1.4	-1.9	-2.3
Social responses	3.0	3.9	6.3	-1.9	2.0	-1.2	-2.0	-2.5
Social time	0.2	0.3	0.7	0.4	-0.3	-0.0	0.5	-0.8
Soleus weight	0.2	0.6	1.3	0.5	-0.3	1.1	0.1	1.1
Bone: stiffness	1.1	1.8	3.3	1.8	-1.0	1.5	0.9	1.2
Tibialis anterior weight	8.0	27.4	34.0	5.1	-5.1	5.8	4.7	5.4
Time to tail flick, vehicle, before self-admin	2.7	2.7	3.3	1.7	-1.8	1.4	1.8	1.6
Time to tail flick, vehicle, after self-admin	1.3	1.4	1.7	1.3	-1.1	0.9	1.3	1.1
Time to tail flick, test, before self-admin	0.1	0.1	0.4	0.4	-0.3	-0.1	0.6	-0.1
Time to tail flick, test, after self-admin	4.0	4.1	6.1	-2.5	1.8	-1.7	-1.9	-2.1
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	0.6	-0.6	0.8	-0.7	-0.8	-0.8
Delta time to tail flick, test, before/after SA	3.3	3.0	4.8	-2.2	1.6	-1.3	-1.9	-1.5
Tibia length	1.9	5.3	8.4	2.4	-2.8	1.6	2.9	1.4
Ambulatory time before self-admin	0.0	0.0	0.1	0.2	0.1	-0.1	-0.2	-0.1
Ambulatory time after self-admin	0.1	0.2	0.3	0.5	-0.2	0.5	0.2	0.4
Bone: tissue strength	0.4	0.3	0.6	-0.7	0.3	-0.8	-0.1	-0.7
Total heroin consumption	0.3	0.4	0.8	0.3	-0.5	0.9	0.6	0.6
Bone: trabecular number	0.6	0.9	2.0	-0.7	0.6	-1.0	-0.6	-1.4
Bone: trabecular spacing	1.4	1.8	3.4	1.1	-0.9	1.7	0.8	1.8
Bone: trabecular thickness	0.6	0.8	1.2	1.1	-0.9	0.8	0.7	0.8
Bone: trabecular tissue density	1.9	2.7	4.2	1.6	-1.5	1.3	1.6	2.0
Water consumed over 24 hours	1.4	1.7	1.9	1.3	-1.4	1.2	1.4	1.1
Number of responses in last shaping day	0.1	0.1	0.2	-0.5	0.2	-0.3	-0.1	-0.2