Prss52

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Prss52	0.15	0.07	4.4e-15	0.16	0.16	0.16	0.16	7.6e-15	5.2e-15	8.6e-15	5.7e-15
2	NAcc	gene expression	Prss52	0.06	0.03	5.2e-08	0.04	0.05	0.06	0.06	8.0e-07	1.0e-07	3.1e-09	3.1e-09
3	BLA	gene expression	Prss52	0.13	0.07	7.7e-06	0.09	0.09	0.06	0.06	1.1e-05	2.9e-05	3.0e-04	2.7e-04
4	PL	gene expression	Prss52	0.1	0.06	1.2e-08	0.09	0.08	0.08	0.09	3.6e-10	1.1e-08	8.0e-09	3.1e-10
5	Liver	gene expression	Prss52	0.04	0.03	5.3e-04	0.03	0.02	0.02	0.02	7.8e-04	3.6e-03	6.6e-03	2.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.4	0.8	2.0	1.4	0.9	-0.5	0.6	-0.8
Area under the delay curve	3.9	6.1	9.8	-3.1	-1.1	2.4	-2.5	2.7
BMI with tail	0.7	2.6	4.9	-1.5	-1.0	2.2	-1.1	1.9
BMI without tail	0.0	0.1	0.2	0.2	-0.1	0.3	0.5	-0.1
Body weight	1.2	5.4	8.4	-2.0	-2.3	2.9	-2.0	2.3
Weight adjusted by age	0.7	2.2	4.6	-0.8	-2.1	1.5	-1.1	1.4
Bone surface	0.3	0.5	1.3	1.1	0.7	-0.3	0.4	-0.7
Bone volume	0.1	0.3	0.6	0.7	0.8	0.1	0.3	-0.3
Breakpoint value in progressive ratio session	0.5	0.9	1.6	-1.3	-0.5	0.9	-0.9	1.1
Number of licking bursts	0.1	0.2	0.6	-0.8	-0.3	0.1	-0.3	0.5
Context. condit. distance diff. score	1.4	1.8	4.7	0.6	2.2	-0.6	1.6	-0.9
Locomotion velocity, session 1	0.2	0.2	0.4	-0.4	-0.1	0.6	-0.6	0.4
Locomotion distance, session 1	0.0	0.1	0.1	0.1	-0.1	0.3	-0.4	-0.2
Locomotion velocity, session 2	0.5	0.6	1.2	-0.6	0.2	1.1	-1.0	0.5
Locomotion distance, session 2	0.1	0.1	0.4	0.6	0.2	0.1	-0.3	-0.4
Locomotion velocity, session 3	1.0	1.1	3.0	-0.8	-1.7	0.5	-1.0	0.8
Locomotion distance, session 3	0.3	0.4	0.7	-0.7	-0.8	0.4	-0.4	0.6
Stereotopy head waving bouts, day 3	0.6	0.7	1.7	0.8	-0.6	-1.3	0.4	-0.9
Stereotopy head waving duration, day 3	0.4	0.5	2.0	-0.2	-1.4	-0.4	-0.6	0.1
Locomotion velocity, session 7	1.3	1.5	2.9	0.9	1.7	-0.3	1.5	-1.1
Locomotion distance, session 7	2.5	3.2	5.8	1.5	2.4	-1.2	2.0	-1.4
Stereotopy head waving bouts, day 7	1.6	1.9	3.3	-1.1	-1.8	1.2	-1.4	1.3
Stereotopy head waving duration, day 7	2.5	3.1	6.5	-1.5	-2.6	1.3	-1.7	1.4
Locomotion velocity, session 8	0.2	0.3	0.4	-0.5	0.4	0.6	-0.5	0.5
Locomotion distance, session 8	0.4	0.5	1.7	0.5	1.3	-0.1	0.6	-0.6
Degree of sensitization distance	6.1	6.6	11.9	2.3	3.5	-1.9	2.7	-2.2
Degree of sensitization stereotypy	1.9	2.1	2.7	-1.4	-1.4	1.6	-1.3	1.4
Conditioned locomotion	0.7	0.8	1.6	0.6	1.2	-0.2	1.3	-0.6
Cocaine response after cond. corrected	0.3	0.4	1.1	-0.4	1.1	-0.2	0.9	-0.1
Cocaine response after cond. not corrected	0.2	0.2	0.6	-0.4	0.8	-0.2	0.6	0.0
Cocaine response before conditioning	0.4	0.4	0.9	-0.1	-1.0	0.4	-0.8	0.6
Saline control response	0.2	0.3	0.5	0.1	-0.6	-0.7	-0.5	-0.3
Bone: connectivity density	1.6	2.5	5.1	2.3	0.8	-1.4	1.2	-1.8
Bone: cortical apparent density	0.1	0.2	0.6	-0.8	-0.6	0.0	-0.3	0.1
Bone: cortical area	0.8	1.2	2.0	-1.4	-0.4	1.2	-1.0	1.2
Bone: cortical porosity	2.1	2.3	3.6	-1.6	-1.1	1.6	-1.4	1.9
Bone: cortical porosity	1.7	1.9	2.7	-1.4	-1.2	1.3	-1.3	1.7
Bone: cortical thickness	1.4	2.3	4.2	-2.1	-0.8	1.5	-1.5	1.5
Bone: cortical thickness	1.2	1.4	3.3	-1.8	0.6	1.2	-0.9	1.0
Bone: cortical tissue density	0.1	0.2	0.5	-0.7	-0.6	-0.1	-0.1	0.0
Condit. Reinf. active minus inactive responses	0.4	0.5	0.8	-0.4	-0.9	0.9	-0.7	0.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.3	-0.2	-0.5	0.1	-0.3
Condit. Reinf. active responses	0.6	0.8	1.3	-0.6	-0.9	1.1	-0.9	0.9
Condit. Reinf. inactive responses	0.4	0.5	0.7	-0.5	-0.7	0.8	-0.7	0.7
Incentive salience index mean	2.4	3.1	4.3	-1.4	-1.5	2.1	-1.8	1.9
Condit. Reinf. lever presses	3.5	5.2	7.5	-1.9	-1.6	2.7	-2.3	2.7
Condit. Reinf. active minus inactive responses	0.3	0.5	0.8	0.5	0.9	-0.7	0.5	-0.9
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.3	0.4	-0.5	0.1	-0.5
Condit. Reinf. active responses	0.4	0.6	1.1	0.7	1.1	-0.5	0.6	-0.7
Condit. Reinf. inactive responses	0.7	1.1	1.8	1.0	1.4	-0.7	1.1	-1.0
Condit. Reinf. lever presses	0.1	0.1	0.2	0.5	-0.5	0.3	-0.5	0.1
Condit. Reinf. lever reinforcers received	0.1	0.2	0.5	0.4	0.7	-0.3	0.3	-0.5
Conditioned reinforcement - actives	1.5	6.0	6.6	2.6	2.4	-2.5	2.5	-2.2
Conditioned reinforcement - inactives	0.6	1.5	2.6	1.6	0.4	-1.5	0.9	-1.3
Conditioned locomotion	1.8	2.6	4.4	0.8	2.1	-1.9	1.7	-1.3
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.1	-0.6	0.5	-0.7	0.0
Patch foraging indifference point AUC	0.3	0.6	0.9	0.2	0.9	-0.8	0.8	-0.9
Delay disc. indifference point, 0s delay	0.1	0.2	0.5	-0.2	0.7	0.1	-0.1	0.5
Delay disc. indifference point, 16s delay	1.9	2.7	5.9	-2.4	-0.7	1.7	-1.5	1.4
Delay disc. indifference point, 2s delay	0.6	0.7	0.9	-0.9	-0.1	0.8	-1.0	1.0
Delay disc. indifference point, 24s delay	1.8	2.9	6.4	-2.5	-0.2	1.9	-1.4	1.7
Delay disc. indifference point, 4s delay	5.1	5.4	7.1	-2.6	-1.5	2.2	-2.5	2.7
Delay disc. indifference point, 8s delay	3.7	6.1	9.3	-3.0	-1.3	2.5	-2.4	2.8
Indifference point function ln k	0.5	1.6	2.5	-0.9	-1.0	1.6	-1.3	1.5
Indifference point function log k	0.5	1.6	2.5	-0.9	-1.0	1.6	-1.3	1.5
Patch foraging total patch changes 0 sec	0.2	0.7	1.2	-0.4	-1.0	0.9	-1.1	0.5
Patch foraging total patch changes 12 sec	0.1	0.1	0.3	-0.3	-0.5	0.2	-0.5	-0.1
Patch foraging total patch changes 18 sec	0.3	0.6	1.5	0.4	0.7	-0.5	0.8	-1.2
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	-0.0	-0.2	-0.1	-0.3	-0.3
Patch foraging total patch changes 6 sec	0.0	0.1	0.1	-0.0	-0.2	-0.1	-0.3	-0.3
Patch foraging time to switch 0 sec	0.0	0.1	0.2	0.3	0.4	-0.1	0.2	-0.1
Patch foraging water rate 0 sec	0.3	1.3	1.8	-1.2	-1.4	1.1	-1.2	0.8
Patch foraging water rate 12 sec	0.2	0.7	1.1	-0.8	-0.6	0.8	-0.9	1.1
Patch foraging water rate 18 sec	1.7	3.7	4.2	-2.0	-2.1	1.6	-2.0	2.0
Patch foraging water rate 24 sec	0.2	0.3	0.6	-0.5	-0.0	0.8	-0.2	0.7
Patch foraging water rate 6 sec	0.9	1.3	2.3	-1.1	-1.5	0.9	-1.2	0.8
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.6	0.1	0.5	0.8	0.5	-0.1
Distance traveled before self-admin	0.1	0.2	0.4	0.4	-0.3	-0.3	0.1	-0.6
Distance traveled after self-admin	0.2	0.4	0.7	-0.9	-0.3	0.7	-0.6	0.7
Extensor digitorum longus weight	7.4	29.5	32.3	-5.7	-5.3	5.4	-5.3	5.5
Bone: elastic displacement	0.4	0.5	1.3	0.6	0.3	-1.1	0.4	-0.7
Bone: elastic work	0.3	0.4	0.9	-0.4	-0.9	0.2	-0.7	0.3
Bone: endosteal estimation	0.1	0.2	0.5	0.7	0.3	-0.1	0.5	-0.3
Bone: endosteal perimeter	0.4	0.9	1.9	1.4	0.7	-0.7	1.0	-0.8
Epididymis fat weight	0.0	0.1	0.4	-0.7	0.1	0.1	0.1	-0.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	0.3	0.2	0.6	0.5	0.1
Delta time in open arm before/after self-admin	0.2	0.2	0.4	-0.3	-0.5	-0.5	-0.7	-0.1
Diff in mean of infusions in LGA sessions	2.4	4.3	8.1	-2.0	-2.8	1.8	-2.0	1.5
Delay discount exponential model param	5.2	7.1	11.3	3.4	1.2	-2.6	2.7	-2.9
Extinction: sum of active levers before priming	0.1	0.2	0.6	-0.4	-0.8	0.0	-0.3	0.3
Active lever presses in extinction session 6	0.2	0.2	0.6	0.2	0.8	-0.2	0.5	-0.3
Bone: final force	1.2	2.0	3.4	-1.5	-0.9	1.8	-1.3	1.4
Bone: final moment	1.1	1.7	2.6	-1.3	-1.1	1.6	-1.2	1.3
Food consumed during 24 hour testing period	0.1	0.1	0.4	0.2	-0.6	-0.2	-0.3	0.2
Glucose	0.1	0.2	0.4	-0.6	0.2	-0.2	-0.5	0.4
Heart weight	0.3	0.4	0.8	0.6	0.6	-0.5	0.9	-0.7
Delay discount hyperbolic model param	4.8	6.2	9.5	3.1	1.1	-2.4	2.6	-2.8
Intermittent access intake day 1-15 change	0.3	1.7	2.6	1.4	0.9	-1.3	1.2	-1.6
Intermittent access intake escalation	0.2	0.9	1.4	1.0	0.5	-1.0	0.9	-1.2
Intermittent access intake escalation 2	0.3	0.5	0.8	0.7	0.4	-0.9	0.6	-0.9
Intermitt. access day 1 inactive lever presses	0.1	0.7	1.2	1.0	0.5	-0.5	0.7	-1.1
Intermitt. access day 15 inactive lever presses	0.0	0.2	0.2	0.4	-0.5	-0.0	-0.5	0.4
Intermitt. access escalation Index	0.1	0.2	0.8	0.3	0.9	0.1	0.4	-0.2
Intermittent access day 1 total infusions	0.2	0.6	1.4	0.5	1.2	-1.0	0.5	-0.3
Intermittent access day 15 total infusions	0.9	2.2	2.9	1.5	1.6	-1.7	1.3	-1.4
Intermittent access terminal intake (last 3 days)	1.4	2.4	3.5	1.5	1.7	-1.9	1.2	-1.5
Intermittent access total infusions	2.3	2.7	4.4	1.4	2.1	-1.7	1.4	-1.4
Intermittent access day 1 locomotion	0.1	0.3	0.5	-0.6	-0.2	0.1	-0.6	0.7
Intermittent access day 15 total locomotion	0.3	1.1	2.7	0.8	0.9	-1.7	0.7	-0.9
Intermittent access total locomotion	0.2	0.2	0.7	0.3	0.5	-0.9	0.1	-0.2
Intermittent access standard deviation	0.2	1.1	1.7	1.1	0.8	-1.3	0.8	-1.1
Left kidney weight	0.4	3.2	5.0	-1.1	-2.2	2.0	-1.7	1.6
Right kidney weight	0.9	6.0	10.7	-1.5	-3.3	2.8	-2.3	1.9
Cocaine induced anxiety	0.7	1.9	3.0	-1.3	-1.1	1.7	-1.3	1.4
Post-drug Anxiety	1.1	1.3	2.0	-0.7	-1.4	1.3	-1.1	0.9
Baseline Anxiety	0.1	0.1	0.3	0.2	-0.4	-0.5	0.1	-0.2
Tail length	0.1	0.7	1.1	1.0	-0.7	-0.8	0.4	-1.0
Length with tail	0.2	1.1	3.2	-0.5	-1.8	0.8	-1.1	0.4
Length without tail	1.2	6.4	6.8	-2.5	-2.5	2.4	-2.6	2.5
Times rat made contact with spout	0.1	0.1	0.2	0.2	0.4	0.4	-0.2	0.4
Lifetime Intake	2.1	2.6	4.3	1.4	2.1	-1.7	1.3	-1.3
Liver weight, left	1.3	2.2	4.5	-1.1	-2.1	1.1	-1.6	1.2
Liver weight, right	1.2	2.1	3.7	-1.8	-1.9	0.8	-1.6	0.8
Locomotor activity	3.0	4.7	8.2	-1.7	-2.9	2.2	-2.2	1.7
Locomotor testing distance	0.2	0.4	1.2	0.2	-1.1	0.5	-0.7	-0.1
Locomotor testing rearing	0.2	0.7	1.8	1.4	-1.1	-0.3	-0.1	-0.7
Locomotion in novel chamber	0.4	0.6	1.3	-0.6	-1.0	1.1	-0.6	0.4
Locomotion in novel chamber post-restriction	0.1	0.2	0.6	-0.5	-0.3	0.8	-0.1	0.1
Fecal boli incidents, locomotor time 1	0.0	0.1	0.3	-0.2	0.5	0.0	0.3	0.4
Change in fecal boli incidents, locomotor task	0.2	0.2	0.5	0.3	-0.7	-0.3	-0.3	-0.6
Time >=10cm from walls, locomotor time 1	0.2	0.3	1.0	0.5	-1.0	0.0	-0.1	-0.5
Bouts of movement, locomotor time 1	0.2	0.3	0.8	-0.3	0.4	0.9	-0.3	0.5
Total resting periods, locomotor time 1	0.2	0.3	0.9	-0.2	1.0	0.6	0.1	0.2
Rest time, locomotor task time 1	0.2	0.3	0.6	-0.2	0.8	0.8	0.2	0.1
Distance moved, locomotor task time 1	0.1	0.4	0.8	0.5	-0.3	-0.9	0.4	-0.7
Vertical activity count, locomotor time 1	0.1	0.5	1.5	-0.2	-1.2	-0.8	-0.4	0.2
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.7	0.5	-0.8	-0.1	0.2	-0.4
Bouts of movement, locomotor time 2	0.6	2.1	3.3	-1.8	-0.6	1.5	-1.6	1.5
Total resting periods, locomotor time 2	0.7	2.8	4.4	-2.1	-0.8	1.7	-1.9	1.7
Rest time, locomotor task time 2	0.8	1.4	2.7	-1.6	-0.1	1.4	-1.1	1.0
Distance moved, locomotor task time 2	0.3	0.5	0.7	0.8	-0.1	-0.9	0.7	-0.7
Vertical activity count, locomotor time 2	0.1	0.2	0.7	0.2	-0.3	-0.8	0.3	0.1
Light reinforcement 1	0.0	0.2	0.3	-0.3	0.0	0.6	-0.6	0.4
Light reinforcement 2	0.1	0.3	0.6	0.3	0.8	-0.4	0.7	-0.4
Bone: marrow area	0.1	0.2	0.6	0.8	0.4	-0.2	0.6	-0.3
Bone: maximum diameter	0.1	0.3	0.6	-0.8	0.1	0.4	-0.4	0.6
Bone: maximum force	1.2	2.4	3.2	-1.7	-1.0	1.8	-1.4	1.6
Bone: maximum moment	1.2	2.2	2.5	-1.6	-1.2	1.6	-1.5	1.6
Mean time between licks in bursts	0.7	4.1	6.1	2.5	1.5	-1.9	2.2	-2.0
Mean num. licks in bursts	0.1	0.3	0.8	0.9	0.7	0.1	0.3	-0.4
Cd content in liver	0.6	0.7	2.4	0.0	-1.6	-0.1	-1.1	-0.0
Co content in liver	1.4	1.6	2.8	-1.3	-0.4	1.4	-1.1	1.7
Cu content in liver	1.1	1.3	2.4	-0.8	-0.6	1.5	-1.1	1.4
Fe content in liver	1.1	1.4	2.3	1.4	0.6	-1.5	0.9	-1.2
K content in liver	0.3	0.3	0.6	0.5	0.8	-0.5	0.7	-0.1
Mg content in liver	2.1	2.3	2.8	1.7	1.5	-1.4	1.5	-1.3
Mn content in liver	1.0	1.1	2.0	1.1	1.1	-0.7	1.4	-0.8
Na content in liver	6.3	7.1	9.7	-2.4	-3.0	2.2	-3.1	2.5
Rb content in liver	1.2	1.4	2.6	1.4	0.5	-1.6	0.9	-1.2
Se content in liver	0.0	0.1	0.1	0.4	-0.3	-0.1	0.1	0.2
Sr content in liver	0.6	0.6	1.3	1.1	0.0	-0.8	0.5	-0.8
Zn content in liver	0.5	0.5	1.4	1.2	0.8	-0.6	0.5	-0.4
Bone: minimum diameter	0.2	0.5	0.8	-0.7	-0.2	0.9	-0.7	0.7
Time in familiar zone, hab. session 1	0.2	0.3	1.0	0.1	1.0	-0.0	0.6	-0.0
Time in novel zone, hab. session 1	0.9	1.0	2.3	-1.1	-1.5	0.2	-1.2	0.4
Total zone transitions, hab. session 1	0.4	0.5	0.8	-0.9	-0.4	0.9	-0.8	0.4
Total locomotion distance, hab. session 1	0.0	0.1	0.2	-0.1	0.2	0.0	-0.2	-0.4
Locomotion velocity, hab. session 1	0.0	0.1	0.2	-0.1	-0.0	0.3	-0.4	-0.0
Time in familiar zone, hab. session 2	0.3	0.3	0.6	0.3	0.6	-0.7	0.8	-0.2
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.1	-0.2	0.3	-0.5	-0.1
Total zone transitions, hab. session 2	0.7	0.9	1.8	-0.7	-0.6	1.3	-0.8	1.1
Total locomotion distance, hab. session 2	0.4	0.5	1.4	-0.5	-0.1	1.2	-0.4	0.7
Locomotion velocity, hab. session 2	0.7	0.9	2.1	-0.8	-0.3	1.5	-0.7	1.1
Novel to familiar place preference ratio	0.3	0.4	0.8	0.6	0.9	-0.4	0.4	-0.9
Novelty place preference	0.3	0.4	0.6	0.7	0.8	-0.2	0.4	-0.8
Time in novel zone, NPP test	0.2	0.2	0.5	0.6	0.6	-0.2	0.2	-0.7
Total zone transitions, NPP test	0.2	0.3	1.3	-0.1	0.2	1.1	-0.1	0.5
Total locomotion distance, NPP test	0.9	1.2	2.2	1.5	1.1	-0.3	1.2	-0.9
Locomotion velocity, NPP test	0.9	1.3	2.2	1.5	1.3	-0.3	1.3	-0.9
Intraocular pressure	4.0	6.5	11.2	2.7	1.7	-3.3	1.9	-2.7
Delta distance traveled before/after self-admin	0.7	0.8	1.4	-1.2	-0.3	0.5	-1.0	1.1
Delta ambulatory time before/after self-admin	0.2	0.4	0.9	-0.9	-0.1	0.1	-0.6	0.9
Parametrial fat weight	1.6	3.9	5.9	1.9	2.4	-1.5	2.0	-1.8
Pavlov. Cond. lever latency	2.2	2.8	4.6	1.4	0.7	-2.1	1.6	-2.2
Pavlov. Cond. magazine entry latency	0.7	0.9	1.1	-0.8	-0.9	1.0	-1.1	1.0
Pavlov. Cond. change in total contacts	4.0	4.4	5.6	-2.1	-1.6	2.1	-2.4	2.2
Pavlov. Cond. index score	4.7	5.9	8.1	-2.2	-1.9	2.7	-2.4	2.8
Pavlov. Cond. latency score	3.6	4.6	6.6	-1.9	-1.5	2.5	-2.1	2.6
Pavlov. Cond. lever contacts	2.8	3.4	5.6	-1.5	-0.9	2.3	-1.7	2.4
Pavlov. Cond. magazine entry number	2.8	3.5	4.4	1.7	1.8	-1.9	1.9	-2.1
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.0	-0.3	0.4	0.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	5.3	6.6	8.9	-2.3	-2.0	2.8	-2.6	3.0
Pavlov. Cond. response bias	3.2	4.0	5.4	-1.9	-1.5	2.2	-1.9	2.3
Pavlov. Cond. lever latency	1.0	1.4	3.2	0.5	1.8	-0.7	1.6	-0.7
Pavlov. Cond. magazine entry latency	1.5	2.2	2.4	-1.5	-1.5	1.5	-1.5	1.3
Pavlov. Cond. change in total contacts	1.4	3.3	7.8	-1.5	-2.8	1.2	-2.0	1.1
Pavlov. Cond. index score	1.8	2.8	5.3	-1.3	-2.3	1.3	-1.9	1.2
Pavlov. Cond. latency score	1.7	2.8	5.4	-1.3	-2.3	1.3	-1.9	1.2
Pavlov. Cond. lever contacts	1.0	1.5	3.3	-0.5	-1.8	0.8	-1.6	0.8
Pavlov. Cond. magazine entry number	0.7	0.9	1.2	1.0	0.8	-1.1	1.0	-0.8
Pavlov. Cond. intertrial magazine entries	4.4	9.6	12.5	3.5	3.2	-2.8	3.0	-2.9
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.9	5.0	-1.5	-2.2	1.4	-2.0	1.3
Pavlov. Cond. response bias	1.6	2.3	3.8	-1.1	-1.9	1.3	-1.9	1.1
Time in closed arm before self-admin	0.8	1.5	2.0	-1.2	-1.0	1.4	-1.2	1.2
Time in closed arm after self-admin	1.0	1.1	3.7	-0.6	-0.2	1.9	-0.1	1.2
Time in open arm before self-admin	0.7	0.8	1.1	1.0	0.7	-0.8	1.0	-0.9
Time in open arm after self-admin	0.4	0.4	1.0	0.6	-0.5	-1.0	-0.0	-0.8
Bone: periosteal estimation	0.0	0.1	0.3	-0.3	0.1	0.5	-0.1	0.4
Bone: periosteal perimeter	0.0	0.0	0.1	0.1	0.3	0.2	0.1	0.2
Bone: post-yield work	0.3	0.6	2.0	-0.8	1.4	0.1	0.4	0.0
Progressive ratio test 1 active lever presses	0.3	0.6	1.0	0.6	1.0	-1.0	0.5	-0.7
Progressive ratio test 1 breakpoint	0.2	0.4	0.8	0.4	0.9	-0.8	0.3	-0.6
Progressive ratio test 1 inactive lever presses	0.3	0.9	1.6	1.3	0.3	-1.1	0.7	-1.1
Progressive ratio test 2 active lever presses	0.7	1.0	1.6	1.3	0.6	-1.1	0.8	-1.0
Progressive ratio test 2 breakpoint	0.5	0.7	1.3	1.1	0.4	-0.9	0.6	-0.8
Progressive ratio test 2 inactive lever presses	0.8	2.4	3.9	2.0	1.1	-1.6	1.4	-1.6
Incentive Sensitization - Responses	0.2	0.7	1.7	1.3	-0.2	-0.8	0.4	-0.9
Incentive Sensitization - Breakpoint	0.3	0.7	1.8	1.3	-0.3	-0.8	0.4	-0.8
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.0	-0.2	-0.4	0.3	-0.2
Progressive ratio	0.3	0.9	2.7	-0.7	-1.6	0.3	-0.9	0.7
Food seeking constrained by brief footshock	0.2	0.2	0.5	-0.0	0.7	-0.4	0.7	-0.2
Seeking ratio, punishment vs. effort	0.2	0.4	1.5	0.0	1.2	0.0	0.6	-0.2
Retroperitoneal fat weight	0.2	0.8	1.8	0.7	1.4	0.2	1.2	-0.5
Reaction time number correct	0.1	0.5	1.0	1.0	0.5	-0.7	0.8	-0.4
Reaction time mean minus median	0.1	0.5	1.4	-0.3	-1.2	0.2	-0.8	0.4
Reaction time mean minus median AUC	0.0	0.2	0.9	0.1	-0.9	0.1	-0.4	-0.0
Reaction time num false alarms	0.6	1.1	2.0	-0.6	-1.4	1.1	-1.2	0.8
Reaction time num false alarms AUC	0.5	1.1	1.6	-0.6	-1.3	1.2	-1.1	0.8
Reaction time trials correct on left	0.1	0.5	1.0	1.0	0.5	-0.7	0.8	-0.4
Reaction time trials on left	0.2	0.7	1.3	1.1	0.6	-0.8	0.9	-0.6
Reaction time mean	0.1	0.2	0.5	0.5	-0.4	-0.7	0.2	-0.2
Reaction time mean AUC	0.1	0.2	0.5	0.4	-0.7	-0.5	-0.0	-0.1
Median of all reaction times	0.2	0.3	0.7	0.7	-0.1	-0.8	0.4	-0.3
Reaction time omissions	2.3	3.7	5.9	2.4	1.4	-1.9	1.9	-1.9
Reaction time false alarm rate	1.2	1.7	2.3	-1.2	-1.3	1.5	-1.4	1.0
Reaction time premature initiation rate	0.2	0.4	0.6	-0.8	-0.7	0.6	-0.5	0.5
Reaction time premature initiations	0.0	0.0	0.0	-0.1	-0.1	0.1	0.0	0.0
Std. dev. reaction times	0.0	0.1	0.2	0.4	-0.3	-0.4	0.0	-0.3
Reaction time trials completed	0.2	0.7	1.3	1.1	0.6	-0.8	0.9	-0.6
Reaction time trials AUC	0.2	0.8	1.5	1.2	0.7	-0.8	1.0	-0.6
Run reversals in cocaine runway, females	0.1	0.1	0.2	0.2	0.1	-0.1	0.3	-0.5
Run reversals in cocaine runway, males	3.2	3.5	5.0	-2.1	-1.8	1.2	-2.2	1.8
Latency to leave start box in cocaine runway	2.0	2.8	3.7	1.7	1.9	-1.7	1.4	-1.6
Latency to leave start box in cocaine runway, F	0.5	0.6	1.2	0.8	0.7	-1.1	0.3	-0.7
Latency to leave start box in cocaine runway, M	2.1	2.0	2.5	1.6	1.5	-1.1	1.5	-1.4
Std. dev. time between licks in bursts	1.0	1.8	2.8	1.7	0.8	-1.5	1.4	-1.2
Total sessions with >9 infusions	0.7	0.8	1.2	1.0	1.0	-1.1	0.7	-0.6
Short access day 1 total inactive lever presses	0.1	0.1	0.5	0.1	0.7	-0.0	0.2	-0.3
Short access day 10 total inactive lever presses	0.1	0.7	0.9	0.7	0.9	-0.5	0.9	-1.0
Short access day 1 total infusions	1.7	3.4	6.7	1.7	2.6	-1.7	1.6	-1.3
Short access day 10 total infusions	0.1	0.1	0.2	-0.1	0.4	-0.4	-0.2	0.1
Short access total infusions	0.6	0.9	1.9	0.8	1.4	-1.1	0.6	-0.5
Short access day 1 locomotion	0.1	0.1	0.3	0.4	0.1	-0.2	0.6	-0.0
Short access day 10 total locomotion	0.0	0.1	0.3	-0.2	-0.4	0.0	-0.4	0.5
Short access total locomotion	0.1	0.1	0.2	-0.1	-0.4	-0.1	-0.3	0.4
One hour access (0.3 mA shock)	0.6	0.8	1.8	0.6	1.3	-0.8	0.6	-0.8
Compulsive drug intake	0.1	0.1	0.6	-0.1	-0.1	0.8	-0.1	0.2
One hour access (shock baseline)	0.6	1.6	2.5	1.1	1.4	-1.6	0.9	-1.1
Social response proportion	2.4	3.0	4.1	2.0	2.0	-1.2	2.0	-1.2
Social responses	3.0	4.0	6.4	2.2	2.5	-1.6	2.2	-1.1
Social time	0.2	0.3	1.1	1.0	-0.4	0.6	0.3	0.1
Soleus weight	0.3	0.9	2.0	-1.4	-0.6	0.8	-0.8	1.0
Bone: stiffness	1.4	2.6	3.9	-1.6	-1.3	2.0	-1.4	1.7
Tibialis anterior weight	8.1	27.8	32.3	-5.2	-5.2	5.0	-5.3	5.7
Time to tail flick, vehicle, before self-admin	1.3	1.6	2.0	-1.3	-1.4	1.2	-1.1	1.1
Time to tail flick, vehicle, after self-admin	0.4	0.8	1.3	-1.1	-1.1	0.8	-1.0	0.4
Time to tail flick, test, before self-admin	0.1	0.1	0.1	0.3	-0.1	0.4	0.2	-0.3
Time to tail flick, test, after self-admin	4.9	5.2	7.3	2.7	2.1	-2.1	2.4	-2.0
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.9	0.8	0.7	-0.4	0.6	-1.0
Delta time to tail flick, test, before/after SA	2.5	3.1	4.0	2.0	1.7	-1.9	1.7	-1.6
Tibia length	1.3	3.6	8.2	-0.7	-2.9	1.7	-2.0	1.6
Ambulatory time before self-admin	0.0	0.0	0.1	0.2	-0.1	0.0	0.1	-0.4
Ambulatory time after self-admin	0.7	1.2	2.0	-1.4	-0.7	1.0	-1.1	1.1
Bone: tissue strength	0.5	0.6	1.3	0.8	0.2	-1.1	0.6	-0.7
Total heroin consumption	0.6	0.7	1.2	-0.9	-1.1	0.2	-0.8	0.9
Bone: trabecular number	0.7	1.3	2.8	1.7	1.0	-0.8	0.8	-1.1
Bone: trabecular spacing	1.8	2.7	5.0	-2.2	-1.3	1.3	-1.3	1.8
Bone: trabecular thickness	0.6	0.9	1.9	-0.7	-0.6	1.4	-0.9	0.9
Bone: trabecular tissue density	2.5	4.3	5.8	-2.4	-2.4	1.7	-2.2	1.5
Water consumed over 24 hours	0.6	1.2	1.5	-0.9	-1.2	1.0	-1.2	1.2
Number of responses in last shaping day	0.3	0.4	1.0	-1.0	-0.5	0.3	-0.7	0.6