Hub : Genes

Car9

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Car9	0.05	0.04	4.6e-05	0.05	0.03	0.04	0.04	2.1e-06	8.9e-05	4.0e-05	1.0e-05
2	Brain	gene expression	Car9	0.11	0.06	1.3e-12	0.12	0.12	0.12	0.12	3.3e-11	6.3e-11	2.1e-11	5.3e-11
3	Liver	gene expression	Car9	0.13	0.07	5.3e-10	0.03	0.07	0.07	0.07	1.1e-04	2.4e-08	3.1e-08	6.5e-08
4	Adipose	gene expression	Car9	0.25	0.11	0.0e+00	0.17	0.17	0.16	0.17	2.0e-18	3.4e-18	1.1e-17	3.1e-18

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.8	1.3	2.4	1.5	1.6	-0.6	-0.4
Area under the delay curve	0.3	0.4	0.6	-0.5	-0.7	-0.3	0.8
BMI with tail	1.5	4.9	10.7	2.6	3.3	-1.1	-0.9
BMI without tail	4.4	9.1	16.1	4.0	3.7	-2.5	0.7
Body weight	2.5	10.4	17.1	4.1	4.1	-2.7	0.5
Weight adjusted by age	0.8	0.9	2.0	0.6	0.1	-1.4	1.2
Bone surface	0.6	1.1	1.7	1.3	1.1	-1.1	0.5
Bone volume	0.5	0.8	1.4	1.2	1.1	-0.7	0.1
Breakpoint value in progressive ratio session	1.3	1.4	3.2	-0.1	-0.7	-1.4	1.8
Number of licking bursts	2.7	3.1	5.8	2.4	2.4	-0.9	-0.5
Context. condit. distance diff. score	0.1	0.1	0.2	-0.4	-0.2	0.4	-0.4
Locomotion velocity, session 1	5.1	5.5	11.7	1.1	0.1	-3.1	3.4
Locomotion distance, session 1	1.5	1.9	3.7	0.9	0.3	-1.7	1.9
Locomotion velocity, session 2	1.5	1.8	4.3	1.5	2.1	-0.4	-0.6
Locomotion distance, session 2	2.0	2.8	4.2	2.0	1.3	-1.8	1.4
Locomotion velocity, session 3	1.0	1.2	2.7	0.4	-0.1	-1.3	1.6
Locomotion distance, session 3	2.6	2.9	4.1	1.8	1.7	-2.0	1.2
Stereotopy head waving bouts, day 3	0.9	1.1	2.5	-0.1	-1.0	-1.0	1.6
Stereotopy head waving duration, day 3	0.5	0.6	1.2	-0.6	-1.1	-0.3	0.9
Locomotion velocity, session 7	0.0	0.0	0.1	-0.3	-0.2	0.2	-0.1
Locomotion distance, session 7	0.3	0.3	0.5	0.7	0.5	-0.7	0.5
Stereotopy head waving bouts, day 7	1.9	2.1	2.8	1.7	1.6	-1.6	0.7
Stereotopy head waving duration, day 7	0.5	0.7	1.0	0.9	0.6	-1.0	0.7
Locomotion velocity, session 8	0.5	0.6	1.6	0.4	-0.4	-0.8	1.3
Locomotion distance, session 8	0.5	0.8	1.5	0.7	0.1	-1.1	1.2
Degree of sensitization distance	1.1	1.1	1.6	-1.1	-1.3	1.2	-0.5
Degree of sensitization stereotypy	1.0	1.1	1.8	1.2	1.3	-1.1	0.3
Conditioned locomotion	0.7	0.8	1.8	-0.0	-0.2	-1.2	1.3
Cocaine response after cond. corrected	1.8	2.0	3.3	-1.1	-1.8	-0.6	1.8
Cocaine response after cond. not corrected	2.0	2.2	4.3	-0.9	-1.8	-0.8	2.1
Cocaine response before conditioning	0.4	0.5	1.3	1.1	0.8	-0.3	-0.2
Saline control response	1.5	1.9	3.0	1.4	0.5	-1.7	1.6
Bone: connectivity density	0.4	0.7	1.7	0.9	1.3	-0.2	-0.6
Bone: cortical apparent density	1.2	1.5	3.4	-0.5	0.1	1.6	-1.9
Bone: cortical area	1.4	2.1	4.1	1.8	2.0	-0.3	-0.8
Bone: cortical porosity	0.3	0.4	0.7	-0.8	-0.7	0.5	-0.1
Bone: cortical porosity	0.0	0.0	0.0	-0.1	0.0	-0.1	0.0
Bone: cortical thickness	0.8	1.3	2.2	0.9	1.4	0.5	-1.5
Bone: cortical thickness	0.3	0.3	0.6	-0.3	-0.2	0.8	-0.8
Bone: cortical tissue density	1.1	1.4	3.0	-0.5	-0.0	1.5	-1.7
Condit. Reinf. active minus inactive responses	0.3	0.4	0.8	0.7	0.9	-0.0	-0.4
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.8	-0.9	-0.7	0.9	-0.6
Condit. Reinf. active responses	1.7	2.1	4.4	1.9	2.1	-0.5	-0.5
Condit. Reinf. inactive responses	1.9	2.3	4.8	1.9	2.2	-0.4	-0.8
Incentive salience index mean	2.9	3.6	6.3	2.4	2.5	-1.4	0.2
Condit. Reinf. lever presses	7.9	10.5	16.6	4.1	3.8	-3.0	1.4
Condit. Reinf. active minus inactive responses	0.4	0.6	1.1	1.0	1.0	-0.3	-0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	0.3	0.6	0.2	-0.5
Condit. Reinf. active responses	1.5	2.1	4.0	2.0	1.9	-1.0	0.1
Condit. Reinf. inactive responses	1.8	2.3	4.3	2.0	2.1	-0.6	-0.5
Condit. Reinf. lever presses	1.5	2.1	4.2	1.7	2.1	0.0	-1.1
Condit. Reinf. lever reinforcers received	1.8	2.5	4.7	2.2	2.1	-1.0	0.1
Conditioned reinforcement - actives	0.2	0.2	0.5	0.3	0.7	-0.2	-0.2
Conditioned reinforcement - inactives	0.0	0.0	0.1	-0.3	-0.1	-0.1	0.3
Conditioned locomotion	0.4	0.4	1.0	0.5	1.0	-0.7	0.2
Patch foraging indifference point 0 sec	2.7	4.4	8.8	1.0	0.5	-3.0	2.7
Patch foraging indifference point AUC	6.2	7.1	12.1	3.5	3.3	-2.3	0.7
Delay disc. indifference point, 0s delay	0.8	0.9	2.0	-1.1	-1.4	0.1	0.7
Delay disc. indifference point, 16s delay	1.2	1.2	2.2	-0.7	-1.2	-0.8	1.5
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	-0.0	0.2	0.4	-0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.4	-0.5	0.3	-0.0
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	-0.3	-0.3	0.1	0.1
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	0.1	0.2	-0.1	0.2
Indifference point function ln k	1.8	2.5	4.5	-2.1	-2.1	1.1	-0.1
Indifference point function log k	1.8	2.5	4.5	-2.1	-2.1	1.1	-0.1
Patch foraging total patch changes 0 sec	2.8	4.6	9.1	1.3	0.9	-3.0	2.6
Patch foraging total patch changes 12 sec	1.9	2.4	4.1	1.8	2.0	-1.5	0.3
Patch foraging total patch changes 18 sec	0.9	1.2	1.7	1.3	1.0	-1.2	0.8
Patch foraging total patch changes 24 sec	2.9	3.6	4.8	2.1	1.9	-2.2	1.1
Patch foraging total patch changes 6 sec	4.0	5.9	9.2	2.4	2.2	-3.0	2.0
Patch foraging time to switch 0 sec	3.1	4.7	6.5	-2.5	-2.2	2.4	-1.3
Patch foraging water rate 0 sec	2.6	4.2	7.0	2.0	1.8	-2.6	1.5
Patch foraging water rate 12 sec	0.2	0.3	0.7	0.3	-0.1	-0.8	0.7
Patch foraging water rate 18 sec	0.3	0.4	0.9	0.5	1.0	-0.3	-0.5
Patch foraging water rate 24 sec	0.5	0.7	1.8	-0.2	0.5	0.8	-1.4
Patch foraging water rate 6 sec	0.4	0.6	1.0	1.0	0.8	-0.8	0.3
Seeking ratio, delayed vs. immediate footshock	2.5	2.9	7.3	1.7	2.7	-1.0	-0.3
Distance traveled before self-admin	4.0	4.2	6.8	2.6	1.9	-2.3	1.2
Distance traveled after self-admin	0.3	0.4	0.7	0.7	0.8	0.3	-0.6
Extensor digitorum longus weight	3.4	13.3	22.4	4.7	4.6	-3.1	0.6
Bone: elastic displacement	3.8	4.3	6.7	-2.6	-2.0	2.2	-1.4
Bone: elastic work	3.8	4.9	7.8	-1.9	-0.8	2.8	-2.7
Bone: endosteal estimation	1.0	2.1	3.1	1.8	1.1	-1.6	1.2
Bone: endosteal perimeter	1.3	2.7	3.7	1.8	1.2	-1.9	1.5
Epididymis fat weight	0.3	0.8	1.3	1.1	0.8	-0.9	0.5
Delta time in closed arm before/after self-admin	1.8	1.7	3.5	1.4	1.9	0.2	-1.2
Delta time in open arm before/after self-admin	0.4	0.4	0.6	-0.6	-0.7	-0.3	0.8
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	-0.3	-0.0	0.4	-0.3
Delay discount exponential model param	0.3	0.3	0.6	0.4	0.6	0.3	-0.8
Extinction: sum of active levers before priming	1.2	1.2	2.3	-1.5	-1.3	0.8	0.1
Active lever presses in extinction session 6	0.1	0.1	0.3	-0.6	-0.3	-0.1	0.4
Bone: final force	0.7	1.1	2.6	1.6	1.3	-0.5	-0.0
Bone: final moment	0.5	0.8	1.8	1.3	1.2	-0.2	-0.3
Food consumed during 24 hour testing period	0.7	0.9	1.5	1.2	0.9	-0.9	0.7
Glucose	0.9	1.4	2.2	1.5	1.4	-1.1	0.4
Heart weight	0.7	1.0	1.3	1.1	1.0	-1.0	0.7
Delay discount hyperbolic model param	0.2	0.3	0.5	0.4	0.5	0.3	-0.7
Intermittent access intake day 1-15 change	0.8	0.8	1.7	0.4	0.9	0.7	-1.3
Intermittent access intake escalation	0.8	0.8	1.2	0.8	1.1	0.4	-1.1
Intermittent access intake escalation 2	1.3	1.3	2.6	0.6	1.2	0.8	-1.6
Intermitt. access day 1 inactive lever presses	0.5	0.6	1.0	0.9	1.0	-0.7	0.2
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.6	0.1	0.0	-0.8	0.7
Intermitt. access escalation Index	1.4	1.2	1.8	1.4	0.5	-1.3	1.0
Intermittent access day 1 total infusions	0.7	0.8	1.7	-0.4	-0.4	-1.0	1.3
Intermittent access day 15 total infusions	0.4	0.4	1.0	0.6	1.0	-0.7	0.1
Intermittent access terminal intake (last 3 days)	0.6	0.6	1.2	0.7	1.1	-0.8	0.3
Intermittent access total infusions	0.9	1.0	1.5	0.9	1.2	-1.2	0.6
Intermittent access day 1 locomotion	0.5	0.5	1.1	-0.7	-0.5	-0.6	1.0
Intermittent access day 15 total locomotion	0.3	0.3	1.0	-1.0	-0.4	-0.1	0.3
Intermittent access total locomotion	0.2	0.2	0.8	-0.9	0.0	0.3	-0.2
Intermittent access standard deviation	0.2	0.2	0.6	0.3	0.8	0.1	-0.5
Left kidney weight	0.7	2.0	3.0	1.4	1.1	-1.7	1.3
Right kidney weight	0.1	0.4	1.0	0.3	0.1	-0.6	1.0
Cocaine induced anxiety	0.9	1.1	2.6	-1.2	-1.6	0.6	0.1
Post-drug Anxiety	0.2	0.2	0.6	0.8	-0.1	-0.4	0.3
Baseline Anxiety	1.1	1.2	2.6	1.3	1.6	0.0	-0.6
Tail length	2.1	6.3	11.6	3.4	2.7	-2.2	1.2
Length with tail	0.9	3.2	4.6	2.1	1.4	-2.0	1.4
Length without tail	0.3	0.6	1.2	-1.1	-1.1	0.1	0.3
Times rat made contact with spout	0.3	0.3	0.6	0.5	0.7	0.2	-0.8
Lifetime Intake	1.7	1.9	3.5	1.0	1.1	-1.9	1.4
Liver weight, left	0.2	0.3	1.0	1.0	0.3	-0.2	0.1
Liver weight, right	0.1	0.1	0.4	-0.1	-0.7	-0.1	0.4
Locomotor activity	0.0	0.0	0.0	0.1	0.2	-0.0	0.0
Locomotor testing distance	0.3	0.5	1.4	0.1	-0.4	-0.8	1.2
Locomotor testing rearing	0.6	1.0	1.5	1.2	0.7	-1.0	0.8
Locomotion in novel chamber	0.3	0.4	0.8	-0.2	0.4	0.8	-0.9
Locomotion in novel chamber post-restriction	1.5	1.8	2.8	1.2	1.7	0.7	-1.6
Fecal boli incidents, locomotor time 1	0.7	0.7	1.2	-1.1	-0.7	1.0	-0.6
Change in fecal boli incidents, locomotor task	1.7	1.6	2.6	1.4	0.7	-1.6	1.2
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.1	0.3	-0.4	-1.0	1.0
Bouts of movement, locomotor time 1	1.4	1.5	2.6	-1.6	-1.4	1.1	-0.3
Total resting periods, locomotor time 1	2.1	2.4	3.6	-1.9	-1.6	1.6	-0.8
Rest time, locomotor task time 1	4.2	4.7	8.4	-1.8	-0.9	2.9	-2.5
Distance moved, locomotor task time 1	3.4	3.7	6.3	1.9	1.1	-2.5	1.9
Vertical activity count, locomotor time 1	3.3	3.5	6.0	1.6	0.3	-2.5	2.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	0.4	0.1	-0.4	0.3
Bouts of movement, locomotor time 2	0.5	0.5	1.1	0.8	1.1	-0.5	0.1
Total resting periods, locomotor time 2	0.2	0.2	0.6	0.5	0.8	-0.2	-0.1
Rest time, locomotor task time 2	0.8	0.9	1.3	-1.1	-1.0	1.0	-0.6
Distance moved, locomotor task time 2	0.3	0.3	0.5	0.5	0.7	0.4	-0.6
Vertical activity count, locomotor time 2	0.3	0.4	0.7	0.9	0.5	-0.5	0.5
Light reinforcement 1	2.9	5.4	9.6	1.8	0.3	-2.9	3.1
Light reinforcement 2	4.0	5.4	11.6	1.2	-0.5	-2.9	3.4
Bone: marrow area	0.9	1.9	3.2	1.8	1.3	-1.5	1.0
Bone: maximum diameter	1.3	2.4	4.6	2.1	2.0	-1.0	-0.1
Bone: maximum force	1.7	2.9	5.8	2.4	2.3	-0.8	-0.2
Bone: maximum moment	1.3	2.2	4.2	2.1	2.0	-0.4	-0.5
Mean time between licks in bursts	0.5	0.7	1.1	-0.7	-1.1	1.0	-0.3
Mean num. licks in bursts	1.4	1.7	3.2	-1.8	-1.6	1.0	-0.2
Cd content in liver	0.6	0.6	0.9	0.9	0.9	0.4	-0.8
Co content in liver	1.0	1.2	3.1	-1.0	-1.8	0.1	0.7
Cu content in liver	1.5	1.8	2.6	-1.3	-1.4	1.6	-1.1
Fe content in liver	1.5	1.8	4.2	0.7	-0.5	-1.5	2.0
K content in liver	0.4	0.4	0.7	-0.3	-0.8	-0.3	0.8
Mg content in liver	0.3	0.3	0.7	-0.7	-0.8	0.1	0.3
Mn content in liver	0.3	0.3	0.7	0.2	0.5	0.6	-0.8
Na content in liver	1.4	1.4	2.9	-1.3	-1.7	1.1	-0.1
Rb content in liver	2.7	3.3	6.8	-2.3	-2.6	1.1	0.3
Se content in liver	1.0	1.2	2.8	1.3	1.7	0.1	-0.8
Sr content in liver	0.3	0.3	0.6	0.7	0.8	-0.2	-0.1
Zn content in liver	0.4	0.4	0.9	0.1	0.5	0.7	-0.9
Bone: minimum diameter	0.1	0.1	0.2	-0.2	0.1	0.4	-0.5
Time in familiar zone, hab. session 1	3.1	2.9	6.4	-0.9	0.2	2.1	-2.5
Time in novel zone, hab. session 1	2.7	2.7	5.1	-0.8	-2.0	-0.9	2.3
Total zone transitions, hab. session 1	0.0	0.0	0.0	0.1	0.1	0.1	-0.1
Total locomotion distance, hab. session 1	0.7	1.0	2.0	0.5	1.0	0.9	-1.4
Locomotion velocity, hab. session 1	1.1	1.6	3.2	1.3	1.8	0.2	-1.1
Time in familiar zone, hab. session 2	1.9	2.0	3.4	-1.1	-0.5	1.8	-1.7
Time in novel zone, hab. session 2	1.7	1.7	3.1	-0.8	-1.5	-0.9	1.8
Total zone transitions, hab. session 2	0.8	1.0	1.4	1.1	0.7	-1.2	1.1
Total locomotion distance, hab. session 2	0.5	0.7	1.4	1.1	1.2	-0.5	0.0
Locomotion velocity, hab. session 2	0.7	0.9	1.9	1.2	1.4	-0.5	-0.1
Novel to familiar place preference ratio	2.3	2.4	4.9	-1.7	-2.2	-0.1	1.3
Novelty place preference	2.9	3.0	6.3	-2.1	-2.5	0.2	1.1
Time in novel zone, NPP test	3.6	3.7	7.9	-2.3	-2.8	0.3	1.2
Total zone transitions, NPP test	1.1	1.5	2.1	1.3	0.7	-1.4	1.4
Total locomotion distance, NPP test	2.0	2.7	3.6	1.9	1.5	-1.9	1.3
Locomotion velocity, NPP test	2.2	3.1	4.3	2.1	1.9	-1.9	1.0
Intraocular pressure	2.3	3.2	4.6	2.1	1.6	-2.1	1.1
Delta distance traveled before/after self-admin	0.9	1.0	1.6	-1.0	-0.9	1.3	-0.7
Delta ambulatory time before/after self-admin	2.0	2.2	3.0	-1.7	-1.5	1.7	-0.8
Parametrial fat weight	0.2	0.4	0.6	0.7	0.3	-0.8	0.6
Pavlov. Cond. lever latency	5.4	6.9	11.7	-3.4	-3.2	2.2	-0.8
Pavlov. Cond. magazine entry latency	0.2	0.3	0.7	0.7	0.8	-0.0	-0.2
Pavlov. Cond. change in total contacts	2.0	2.1	3.5	1.9	1.8	-1.3	0.5
Pavlov. Cond. index score	2.0	2.6	4.7	2.2	2.2	-0.9	0.0
Pavlov. Cond. latency score	1.9	2.5	4.5	2.1	2.1	-1.0	0.1
Pavlov. Cond. lever contacts	3.9	4.6	7.7	2.7	2.8	-1.7	0.5
Pavlov. Cond. magazine entry number	0.5	0.6	1.2	-1.0	-1.1	0.2	0.2
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.5	0.5	-0.1	-0.2
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.2	4.6	2.0	2.1	-0.6	-0.3
Pavlov. Cond. response bias	2.1	2.6	4.6	2.1	2.1	-1.1	0.2
Pavlov. Cond. lever latency	1.7	2.3	4.5	-1.8	-2.1	-0.0	1.2
Pavlov. Cond. magazine entry latency	0.6	0.6	1.2	-0.7	-0.8	1.1	-0.6
Pavlov. Cond. change in total contacts	1.3	1.8	3.7	0.7	1.1	1.2	-1.9
Pavlov. Cond. index score	0.6	0.8	1.8	0.3	0.5	1.0	-1.3
Pavlov. Cond. latency score	0.8	1.0	2.2	0.4	0.8	1.0	-1.5
Pavlov. Cond. lever contacts	0.8	1.1	2.2	1.3	1.5	-0.0	-0.8
Pavlov. Cond. magazine entry number	1.0	1.2	2.7	0.1	-0.3	-1.4	1.6
Pavlov. Cond. intertrial magazine entries	0.4	0.6	0.8	0.8	0.8	-0.9	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.0	0.3	0.5	1.1	-1.4
Pavlov. Cond. response bias	0.5	0.7	1.0	0.8	0.9	0.5	-1.0
Time in closed arm before self-admin	1.4	1.6	3.3	-1.8	-1.6	0.9	-0.1
Time in closed arm after self-admin	0.4	0.4	0.6	-0.5	-0.3	0.8	-0.8
Time in open arm before self-admin	2.4	2.7	4.0	2.0	1.4	-1.8	1.2
Time in open arm after self-admin	1.9	2.0	3.0	1.4	1.2	-1.7	1.3
Bone: periosteal estimation	1.0	2.0	4.0	2.0	1.7	-1.1	0.3
Bone: periosteal perimeter	0.6	1.1	1.5	1.2	0.7	-1.2	1.0
Bone: post-yield work	1.3	1.8	2.7	1.6	1.1	-1.4	1.1
Progressive ratio test 1 active lever presses	1.2	1.3	2.8	0.4	0.5	-1.7	1.4
Progressive ratio test 1 breakpoint	1.3	1.4	2.9	0.6	0.7	-1.7	1.4
Progressive ratio test 1 inactive lever presses	2.4	2.7	4.9	0.9	0.3	-2.2	2.2
Progressive ratio test 2 active lever presses	1.0	1.0	2.3	0.1	0.0	-1.4	1.5
Progressive ratio test 2 breakpoint	0.8	0.9	2.1	-0.2	-0.2	-1.2	1.4
Progressive ratio test 2 inactive lever presses	0.3	0.3	0.6	0.4	0.5	-0.8	0.5
Incentive Sensitization - Responses	0.2	0.2	0.5	-0.1	-0.2	-0.6	0.7
Incentive Sensitization - Breakpoint	0.2	0.2	0.5	-0.2	-0.3	-0.5	0.7
Sum of active levers in priming session hrs 5-6	1.8	1.8	3.3	-1.7	-1.8	0.1	0.9
Progressive ratio	0.0	0.0	0.1	-0.1	-0.0	-0.1	0.3
Food seeking constrained by brief footshock	7.5	9.3	12.6	3.5	2.9	-3.5	2.0
Seeking ratio, punishment vs. effort	1.6	1.9	3.2	1.8	1.3	-1.5	0.6
Retroperitoneal fat weight	0.1	0.5	0.7	-0.8	-0.4	0.8	-0.7
Reaction time number correct	0.3	0.5	0.8	0.6	0.3	-0.9	0.8
Reaction time mean minus median	2.1	2.8	6.5	0.3	1.2	1.8	-2.6
Reaction time mean minus median AUC	1.5	1.9	3.4	0.9	1.5	1.0	-1.8
Reaction time num false alarms	0.2	0.3	0.6	-0.0	0.5	0.6	-0.8
Reaction time num false alarms AUC	0.3	0.4	1.0	0.6	1.0	-0.2	-0.1
Reaction time trials correct on left	0.3	0.5	0.8	0.6	0.3	-0.9	0.8
Reaction time trials on left	0.2	0.4	0.6	0.5	0.2	-0.8	0.7
Reaction time mean	2.9	4.1	7.6	-1.5	-1.0	2.8	-2.3
Reaction time mean AUC	3.3	4.4	8.1	-1.7	-1.0	2.9	-2.4
Median of all reaction times	3.2	4.4	6.8	-2.1	-1.9	2.6	-1.6
Reaction time omissions	1.3	1.8	2.6	-1.6	-1.4	1.4	-0.7
Reaction time false alarm rate	0.2	0.3	0.5	-0.3	0.2	0.7	-0.7
Reaction time premature initiation rate	2.5	3.4	6.0	-2.4	-1.6	1.8	-1.3
Reaction time premature initiations	1.3	1.8	3.6	-1.9	-1.3	1.2	-0.8
Std. dev. reaction times	2.2	3.1	6.7	-0.6	0.2	2.3	-2.6
Reaction time trials completed	0.2	0.4	0.6	0.5	0.2	-0.8	0.7
Reaction time trials AUC	0.2	0.3	0.6	0.5	0.2	-0.8	0.7
Run reversals in cocaine runway, females	0.4	0.4	0.8	0.2	0.3	0.8	-0.9
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.4	0.1	0.2	-0.2
Latency to leave start box in cocaine runway	0.4	0.4	0.9	0.8	1.0	-0.2	-0.4
Latency to leave start box in cocaine runway, F	0.0	0.0	0.0	-0.0	0.0	-0.2	0.2
Latency to leave start box in cocaine runway, M	1.1	1.0	1.7	1.3	0.9	-1.1	0.6
Std. dev. time between licks in bursts	0.3	0.3	0.5	-0.7	-0.6	0.7	-0.2
Total sessions with >9 infusions	1.7	1.9	4.2	0.2	-0.1	-1.8	2.0
Short access day 1 total inactive lever presses	2.2	2.4	3.6	1.6	1.5	-1.9	1.1
Short access day 10 total inactive lever presses	0.1	0.1	0.2	0.4	0.2	-0.2	-0.1
Short access day 1 total infusions	3.1	3.3	6.0	1.3	0.9	-2.4	2.2
Short access day 10 total infusions	1.8	2.0	3.8	0.9	0.7	-2.0	1.7
Short access total infusions	2.0	2.3	4.5	0.6	0.3	-2.0	2.1
Short access day 1 locomotion	0.5	0.5	1.5	-0.2	-0.1	-0.7	1.2
Short access day 10 total locomotion	0.6	0.7	1.1	-1.0	-0.3	1.0	-0.7
Short access total locomotion	0.6	0.6	1.3	0.3	0.3	-1.0	1.1
One hour access (0.3 mA shock)	1.0	1.2	2.0	1.0	0.8	-1.4	1.0
Compulsive drug intake	0.3	0.3	0.6	0.8	0.6	-0.5	0.2
One hour access (shock baseline)	1.0	1.2	2.4	0.6	0.7	-1.6	1.2
Social response proportion	2.7	2.9	4.4	-1.7	-1.7	2.1	-1.2
Social responses	0.3	0.4	0.8	0.9	0.8	-0.2	-0.0
Social time	0.2	0.3	0.7	-0.2	-0.8	0.6	0.1
Soleus weight	1.1	3.1	7.6	0.5	-1.0	-1.9	2.8
Bone: stiffness	2.2	3.5	7.4	2.7	2.4	-0.9	-0.1
Tibialis anterior weight	5.4	18.4	32.0	5.7	4.7	-4.1	1.6
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.7	-1.3	-0.9	0.8	-0.3
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	-0.1	-0.0	-0.3	0.2
Time to tail flick, test, before self-admin	0.2	0.2	0.3	0.5	0.6	-0.1	-0.4
Time to tail flick, test, after self-admin	0.7	0.7	1.4	0.6	1.2	0.3	-1.0
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.5	0.2	-0.2	0.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	-0.4	0.0	0.3	-0.3
Tibia length	0.5	1.3	3.3	0.5	-0.8	-1.0	1.8
Ambulatory time before self-admin	3.9	4.0	5.7	2.3	1.7	-2.4	1.5
Ambulatory time after self-admin	0.1	0.1	0.2	0.5	0.4	-0.3	0.2
Bone: tissue strength	0.2	0.1	0.3	0.4	0.1	0.5	-0.4
Total heroin consumption	0.7	0.8	1.7	-0.5	-0.8	-0.8	1.3
Bone: trabecular number	0.8	1.2	2.6	1.3	1.6	-0.2	-0.7
Bone: trabecular spacing	0.3	0.3	0.8	-0.2	0.1	0.7	-0.9
Bone: trabecular thickness	0.1	0.1	0.2	-0.4	-0.2	0.3	-0.2
Bone: trabecular tissue density	1.4	2.0	4.6	2.1	1.6	-0.9	0.3
Water consumed over 24 hours	0.5	0.6	1.2	1.0	1.1	-0.5	-0.2
Number of responses in last shaping day	2.6	2.7	6.1	0.6	-0.3	-2.1	2.5