Rps6kb2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	isoform ratio	XR_005488929.2	0.02	0.02	3.5e-03	0.03	0.02	0.02	0.02	1.7e-03	4.8e-03	9.0e-03	2.9e-03
2	IC	intron excision ratio	chr1_210883738_210884130	0.11	0.08	4.3e-03	0.06	0.04	0.05	0.04	2.2e-03	7.4e-03	3.3e-03	7.0e-03
3	IC	mRNA stability	Rps6kb2	0.14	0.1	4.4e-03	0.04	0.01	0.02	0.02	1.1e-02	8.3e-02	6.4e-02	3.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	2.6	4.7	7.0	1.2	-2.6	2.4
Area under the delay curve	0.6	0.9	1.1	0.8	-1.0	1.0
BMI with tail	2.4	8.4	13.6	0.7	-3.4	3.7
BMI without tail	0.5	2.8	4.8	-0.3	-1.9	2.2
Body weight	1.1	4.8	5.6	-1.8	-2.4	2.3
Weight adjusted by age	0.2	0.5	1.3	-1.1	-0.2	0.2
Bone surface	2.9	5.8	9.3	0.3	-3.1	2.8
Bone volume	1.9	3.7	5.8	0.8	-2.4	2.2
Breakpoint value in progressive ratio session	0.5	0.9	1.1	-1.1	-0.9	0.9
Number of licking bursts	0.0	0.0	0.0	-0.0	-0.2	0.0
Context. condit. distance diff. score	0.3	0.3	1.0	1.0	-0.0	0.0
Locomotion velocity, session 1	0.0	0.0	0.0	0.0	-0.1	0.1
Locomotion distance, session 1	1.5	2.0	2.9	0.6	-1.7	1.6
Locomotion velocity, session 2	0.6	0.7	1.3	-1.2	-0.6	0.6
Locomotion distance, session 2	0.7	0.9	1.4	-0.2	-1.2	1.2
Locomotion velocity, session 3	1.8	2.0	2.5	1.1	-1.5	1.6
Locomotion distance, session 3	0.2	0.2	0.4	0.3	-0.4	0.6
Stereotopy head waving bouts, day 3	1.4	1.7	2.0	1.4	-1.2	1.2
Stereotopy head waving duration, day 3	0.7	0.9	2.1	1.4	-0.6	0.4
Locomotion velocity, session 7	1.3	1.4	1.9	0.9	-1.2	1.4
Locomotion distance, session 7	0.3	0.4	0.6	-0.1	-0.7	0.8
Stereotopy head waving bouts, day 7	1.3	1.5	2.0	1.4	-1.1	1.1
Stereotopy head waving duration, day 7	1.3	1.6	2.3	0.7	-1.5	1.4
Locomotion velocity, session 8	0.4	0.5	1.0	-1.0	-0.7	0.4
Locomotion distance, session 8	0.2	0.3	0.6	0.8	-0.5	0.5
Degree of sensitization distance	0.4	0.5	0.7	0.1	-0.9	0.8
Degree of sensitization stereotypy	0.5	0.6	0.9	0.4	-1.0	0.8
Conditioned locomotion	2.1	2.5	5.7	-2.4	0.9	-1.0
Cocaine response after cond. corrected	0.1	0.1	0.2	0.5	-0.1	0.2
Cocaine response after cond. not corrected	0.3	0.4	0.6	0.8	-0.5	0.5
Cocaine response before conditioning	0.1	0.1	0.2	0.1	-0.4	0.2
Saline control response	0.8	1.1	2.0	-1.4	-1.0	0.5
Bone: connectivity density	3.5	5.5	9.1	0.4	-3.0	2.7
Bone: cortical apparent density	0.3	0.4	1.0	-1.0	0.4	-0.3
Bone: cortical area	0.6	0.9	1.7	-1.3	0.5	-0.8
Bone: cortical porosity	0.0	0.0	0.0	0.1	-0.2	0.0
Bone: cortical porosity	0.1	0.1	0.1	-0.4	-0.2	-0.0
Bone: cortical thickness	3.0	5.0	12.2	-3.5	1.0	-1.4
Bone: cortical thickness	0.9	1.1	2.9	-1.7	0.2	-0.5
Bone: cortical tissue density	0.3	0.5	1.3	-1.1	0.4	-0.2
Condit. Reinf. active minus inactive responses	0.5	0.5	0.8	0.4	-0.8	0.9
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	0.5	-0.5	0.6
Condit. Reinf. active responses	0.1	0.1	0.2	0.2	-0.2	0.4
Condit. Reinf. inactive responses	0.1	0.1	0.1	0.1	0.4	-0.2
Incentive salience index mean	0.3	0.4	0.6	0.2	-0.7	0.8
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.3	0.1	-0.2
Condit. Reinf. active minus inactive responses	1.1	1.7	2.4	1.6	-1.0	1.3
Condit. Reinf. active-inactive response ratio	0.7	1.1	3.0	1.7	-0.3	0.5
Condit. Reinf. active responses	1.6	2.4	2.9	1.4	-1.5	1.7
Condit. Reinf. inactive responses	0.9	1.4	2.2	0.1	-1.5	1.4
Condit. Reinf. lever presses	1.0	1.5	2.3	0.3	-1.5	1.4
Condit. Reinf. lever reinforcers received	1.8	2.6	3.5	1.2	-1.7	1.9
Conditioned reinforcement - actives	0.2	0.7	1.2	-0.3	1.1	-1.0
Conditioned reinforcement - inactives	0.5	1.5	4.0	2.0	0.5	-0.3
Conditioned locomotion	2.6	3.8	4.6	2.0	2.1	-1.7
Patch foraging indifference point 0 sec	0.1	0.3	0.7	0.8	0.2	-0.2
Patch foraging indifference point AUC	0.4	1.0	2.7	-1.6	0.5	-0.1
Delay disc. indifference point, 0s delay	1.6	1.8	2.2	1.3	-1.2	1.5
Delay disc. indifference point, 16s delay	0.3	0.4	1.0	1.0	0.1	-0.1
Delay disc. indifference point, 2s delay	0.5	0.6	1.1	1.0	-0.5	0.6
Delay disc. indifference point, 24s delay	0.2	0.3	0.5	-0.5	0.5	-0.7
Delay disc. indifference point, 4s delay	0.6	0.6	1.1	0.3	-0.8	1.0
Delay disc. indifference point, 8s delay	0.2	0.4	0.6	0.5	-0.8	0.5
Indifference point function ln k	0.6	1.9	3.3	1.8	1.0	-1.1
Indifference point function log k	0.6	1.9	3.3	1.8	1.0	-1.1
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	0.2	0.6	-0.6
Patch foraging total patch changes 12 sec	0.7	1.0	2.3	-1.5	-0.5	0.7
Patch foraging total patch changes 18 sec	0.1	0.1	0.2	-0.3	-0.3	0.4
Patch foraging total patch changes 24 sec	0.2	0.6	1.6	-1.3	0.3	-0.0
Patch foraging total patch changes 6 sec	0.5	0.8	1.3	-0.1	-1.0	1.1
Patch foraging time to switch 0 sec	0.9	3.6	6.4	0.6	-2.5	2.0
Patch foraging water rate 0 sec	1.7	6.2	10.7	-0.2	3.3	-2.8
Patch foraging water rate 12 sec	1.7	6.9	11.6	0.3	3.4	-3.0
Patch foraging water rate 18 sec	0.5	1.1	1.7	0.2	1.2	-1.3
Patch foraging water rate 24 sec	2.8	4.0	6.2	-0.4	2.5	-2.4
Patch foraging water rate 6 sec	2.4	3.5	5.3	-0.6	2.3	-2.2
Seeking ratio, delayed vs. immediate footshock	0.7	1.0	1.4	0.7	-1.2	1.0
Distance traveled before self-admin	0.2	0.4	0.6	0.3	-0.8	0.8
Distance traveled after self-admin	0.0	0.0	0.1	0.1	-0.3	-0.1
Extensor digitorum longus weight	1.9	7.7	20.9	-4.6	-1.2	0.9
Bone: elastic displacement	2.5	3.2	3.8	-1.5	1.9	-1.9
Bone: elastic work	1.4	1.8	4.6	-2.1	0.5	-0.8
Bone: endosteal estimation	0.9	2.3	5.3	2.3	-0.9	0.9
Bone: endosteal perimeter	1.9	4.8	11.3	3.4	-1.2	1.3
Epididymis fat weight	0.9	4.5	7.3	2.7	1.7	-1.8
Delta time in closed arm before/after self-admin	0.6	0.6	1.7	-1.3	0.0	0.0
Delta time in open arm before/after self-admin	0.3	0.3	0.4	0.6	-0.6	0.6
Diff in mean of infusions in LGA sessions	0.2	0.3	0.9	-1.0	-0.0	-0.2
Delay discount exponential model param	0.5	0.7	0.9	-0.6	0.9	-0.9
Extinction: sum of active levers before priming	0.8	1.2	2.0	-0.4	-1.4	1.2
Active lever presses in extinction session 6	0.5	0.5	1.5	-1.2	-0.1	0.3
Bone: final force	0.4	0.7	0.9	-0.8	-1.0	0.7
Bone: final moment	0.4	0.7	0.8	-0.8	-0.9	0.7
Food consumed during 24 hour testing period	0.3	0.6	1.0	-0.1	0.9	-1.0
Glucose	2.3	3.6	7.1	2.7	-1.3	1.4
Heart weight	1.3	2.1	2.9	1.7	-1.4	1.2
Delay discount hyperbolic model param	0.6	0.8	1.0	-0.7	1.0	-1.0
Intermittent access intake day 1-15 change	0.3	1.7	2.5	1.1	1.2	-1.6
Intermittent access intake escalation	0.3	1.6	2.6	0.9	1.2	-1.6
Intermittent access intake escalation 2	0.7	1.2	1.4	1.1	0.9	-1.2
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	0.2	0.1	-0.1
Intermitt. access day 15 inactive lever presses	0.3	1.4	4.2	2.0	-0.4	0.0
Intermitt. access escalation Index	0.6	1.7	2.5	0.4	1.6	-1.6
Intermittent access day 1 total infusions	1.6	4.9	9.8	3.1	-1.5	1.7
Intermittent access day 15 total infusions	1.3	3.1	9.2	3.0	0.3	-0.4
Intermittent access terminal intake (last 3 days)	2.0	3.4	10.1	3.2	-0.2	0.3
Intermittent access total infusions	2.3	2.8	7.4	2.7	-0.6	0.8
Intermittent access day 1 locomotion	1.2	2.1	4.3	2.1	-0.8	1.2
Intermittent access day 15 total locomotion	0.6	2.4	7.2	2.7	0.2	-0.1
Intermittent access total locomotion	3.2	3.9	11.5	3.4	-0.0	0.2
Intermittent access standard deviation	0.1	0.4	1.2	1.1	0.2	-0.2
Left kidney weight	0.2	1.3	2.7	1.7	0.7	-0.8
Right kidney weight	0.2	1.5	2.4	0.8	1.2	-1.5
Cocaine induced anxiety	0.0	0.1	0.1	0.3	-0.3	0.3
Post-drug Anxiety	0.1	0.2	0.3	-0.2	-0.5	0.4
Baseline Anxiety	0.1	0.2	0.5	-0.7	-0.1	-0.0
Tail length	0.4	2.3	5.3	-2.3	0.8	-0.9
Length with tail	0.9	3.9	11.7	-3.4	-0.1	-0.3
Length without tail	0.5	2.5	7.4	-2.7	-0.3	-0.0
Times rat made contact with spout	0.6	0.6	1.2	0.1	-1.1	0.8
Lifetime Intake	1.6	2.0	5.2	2.3	-0.5	0.8
Liver weight, left	0.6	1.0	1.6	-0.2	1.1	-1.3
Liver weight, right	0.6	1.1	1.8	0.4	1.2	-1.3
Locomotor activity	0.6	1.0	1.5	0.2	1.2	-1.2
Locomotor testing distance	0.4	1.1	1.6	0.2	1.3	-1.3
Locomotor testing rearing	0.1	0.3	0.9	1.0	-0.0	0.2
Locomotion in novel chamber	2.1	2.8	7.5	2.7	0.6	-0.6
Locomotion in novel chamber post-restriction	0.5	1.5	3.2	1.8	0.9	-0.7
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	0.1	0.1	-0.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.1	-0.4	0.3
Time >=10cm from walls, locomotor time 1	2.2	2.7	5.7	2.4	-1.0	1.2
Bouts of movement, locomotor time 1	1.0	1.2	2.7	-1.7	0.7	-0.7
Total resting periods, locomotor time 1	0.8	1.0	1.7	-1.3	0.8	-0.7
Rest time, locomotor task time 1	0.9	1.5	2.3	0.5	1.4	-1.5
Distance moved, locomotor task time 1	0.5	1.5	2.1	0.8	-1.5	1.3
Vertical activity count, locomotor time 1	0.1	0.9	2.2	1.5	-0.5	0.4
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.4	0.0	0.6	-0.4
Bouts of movement, locomotor time 2	0.1	0.2	0.5	-0.7	-0.1	0.2
Total resting periods, locomotor time 2	0.0	0.1	0.1	-0.4	-0.2	0.2
Rest time, locomotor task time 2	0.7	1.2	3.5	1.9	-0.1	0.1
Distance moved, locomotor task time 2	0.6	0.7	1.8	-1.4	0.4	-0.5
Vertical activity count, locomotor time 2	1.0	2.3	2.4	-1.5	1.5	-1.5
Light reinforcement 1	0.1	0.5	0.8	0.3	0.9	-0.9
Light reinforcement 2	0.5	1.2	1.6	0.8	1.3	-1.1
Bone: marrow area	1.0	2.4	5.6	2.4	-0.9	0.9
Bone: maximum diameter	0.1	0.2	0.5	0.1	0.4	-0.7
Bone: maximum force	1.6	3.2	5.3	0.2	-2.3	2.1
Bone: maximum moment	1.5	2.8	4.5	0.1	-2.1	2.0
Mean time between licks in bursts	0.0	0.2	0.5	-0.7	-0.1	0.3
Mean num. licks in bursts	0.1	0.2	0.3	0.3	-0.5	0.5
Cd content in liver	0.5	0.6	1.5	1.2	0.4	-0.3
Co content in liver	1.8	2.1	3.3	-0.8	1.8	-1.5
Cu content in liver	0.0	0.0	0.0	0.1	0.1	0.1
Fe content in liver	0.1	0.1	0.1	-0.4	-0.0	0.3
K content in liver	0.5	0.5	0.8	0.0	-0.9	0.9
Mg content in liver	0.3	0.4	0.8	0.9	-0.4	0.4
Mn content in liver	0.6	0.7	1.2	-1.1	-0.6	0.7
Na content in liver	0.8	0.9	1.0	-0.8	1.0	-1.0
Rb content in liver	1.1	1.2	2.7	1.6	-0.8	0.7
Se content in liver	0.4	0.5	0.8	0.9	-0.6	0.6
Sr content in liver	1.2	1.1	2.7	-1.6	0.5	-0.5
Zn content in liver	0.3	0.3	0.8	-0.9	0.3	-0.4
Bone: minimum diameter	1.5	2.8	4.9	2.2	-1.4	1.2
Time in familiar zone, hab. session 1	0.4	0.4	0.8	0.9	-0.4	0.5
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.4	0.3	-0.5
Total zone transitions, hab. session 1	0.2	0.2	0.5	-0.4	-0.7	0.3
Total locomotion distance, hab. session 1	0.2	0.2	0.7	0.8	-0.1	-0.1
Locomotion velocity, hab. session 1	0.0	0.1	0.1	0.4	-0.1	-0.1
Time in familiar zone, hab. session 2	0.6	0.7	1.5	-1.2	0.5	-0.5
Time in novel zone, hab. session 2	1.0	1.1	1.3	1.1	-1.1	1.0
Total zone transitions, hab. session 2	3.9	5.0	7.5	1.0	-2.7	2.6
Total locomotion distance, hab. session 2	1.4	1.8	2.2	1.2	-1.5	1.4
Locomotion velocity, hab. session 2	1.3	1.7	1.8	1.4	-1.3	1.3
Novel to familiar place preference ratio	0.3	0.4	0.7	0.4	-0.9	0.6
Novelty place preference	0.3	0.4	0.6	0.6	-0.8	0.5
Time in novel zone, NPP test	0.4	0.4	0.7	0.6	-0.8	0.5
Total zone transitions, NPP test	1.1	1.6	2.4	-0.0	-1.5	1.6
Total locomotion distance, NPP test	0.4	0.6	0.8	0.6	-0.7	0.9
Locomotion velocity, NPP test	0.2	0.3	0.5	0.5	-0.5	0.7
Intraocular pressure	0.9	1.5	2.2	-0.4	1.5	-1.5
Delta distance traveled before/after self-admin	0.2	0.2	0.5	-0.3	0.4	-0.7
Delta ambulatory time before/after self-admin	0.2	0.3	0.5	-0.4	0.4	-0.7
Parametrial fat weight	0.9	2.1	6.3	2.5	0.3	-0.1
Pavlov. Cond. lever latency	0.2	0.2	0.3	0.4	0.5	-0.6
Pavlov. Cond. magazine entry latency	0.7	0.9	1.1	0.9	-1.0	0.8
Pavlov. Cond. change in total contacts	0.4	0.4	0.8	0.9	-0.4	0.4
Pavlov. Cond. index score	0.0	0.0	0.0	0.1	-0.0	-0.0
Pavlov. Cond. latency score	0.1	0.1	0.1	0.2	-0.3	0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.1	-0.3	0.4
Pavlov. Cond. magazine entry number	0.0	0.1	0.1	-0.1	-0.1	0.4
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.0	-0.4	1.0	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.1	-0.1	0.1
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.1	0.2	-0.4
Pavlov. Cond. lever latency	0.0	0.1	0.1	0.3	-0.1	0.3
Pavlov. Cond. magazine entry latency	2.0	2.8	4.8	-0.4	-2.2	1.8
Pavlov. Cond. change in total contacts	0.3	0.8	1.3	0.5	-1.1	1.0
Pavlov. Cond. index score	0.5	0.8	1.6	-0.1	-1.3	0.9
Pavlov. Cond. latency score	0.3	0.6	1.1	-0.1	-1.1	0.7
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.2	-0.1	-0.2
Pavlov. Cond. magazine entry number	2.5	3.2	5.3	0.5	2.3	-2.0
Pavlov. Cond. intertrial magazine entries	0.3	0.7	1.1	0.6	1.0	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.0	1.8	-0.2	-1.4	1.1
Pavlov. Cond. response bias	0.6	0.8	1.7	-0.1	-1.3	0.9
Time in closed arm before self-admin	0.5	0.9	2.2	1.5	-0.4	0.6
Time in closed arm after self-admin	0.0	0.0	0.1	0.0	0.3	-0.1
Time in open arm before self-admin	0.8	1.0	2.2	-1.5	0.5	-0.8
Time in open arm after self-admin	0.2	0.2	0.3	-0.5	-0.6	0.4
Bone: periosteal estimation	0.0	0.1	0.3	0.5	-0.1	-0.1
Bone: periosteal perimeter	0.4	0.7	1.0	1.0	-0.8	0.7
Bone: post-yield work	7.0	12.1	13.4	3.2	-3.6	3.7
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	0.4	0.3	0.3
Progressive ratio test 1 breakpoint	0.0	0.1	0.1	0.3	0.3	0.2
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.2	0.4	0.1	0.4
Progressive ratio test 2 active lever presses	0.8	1.1	3.2	1.8	0.2	0.2
Progressive ratio test 2 breakpoint	0.8	1.0	2.8	1.7	0.2	0.1
Progressive ratio test 2 inactive lever presses	1.2	3.8	10.8	3.3	0.6	-0.4
Incentive Sensitization - Responses	0.4	1.0	1.1	1.0	-1.0	1.0
Incentive Sensitization - Breakpoint	0.4	0.9	1.1	1.1	-0.9	0.9
Sum of active levers in priming session hrs 5-6	4.0	3.8	4.4	-1.6	2.1	-2.1
Progressive ratio	1.8	5.2	7.5	1.2	-2.7	2.6
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.0	-0.4	0.4
Seeking ratio, punishment vs. effort	1.4	3.1	4.5	-0.8	2.1	-2.0
Retroperitoneal fat weight	2.2	10.0	19.5	4.4	2.3	-2.3
Reaction time number correct	0.2	0.7	1.5	-1.2	0.6	-0.6
Reaction time mean minus median	0.2	1.2	1.9	-0.3	-1.3	1.4
Reaction time mean minus median AUC	0.1	0.5	0.7	-0.8	-0.6	0.8
Reaction time num false alarms	0.7	1.2	1.4	-0.9	1.2	-1.1
Reaction time num false alarms AUC	0.4	0.8	1.5	-1.2	0.7	-0.7
Reaction time trials correct on left	0.2	0.7	1.5	-1.2	0.6	-0.6
Reaction time trials on left	0.2	0.8	1.8	-1.3	0.6	-0.6
Reaction time mean	0.2	0.5	0.7	0.8	-0.8	0.5
Reaction time mean AUC	0.3	0.7	1.0	1.0	-0.8	0.6
Median of all reaction times	0.5	0.8	1.4	1.2	-0.8	0.5
Reaction time omissions	0.4	0.6	0.7	-0.9	-0.7	0.8
Reaction time false alarm rate	0.2	0.3	0.4	-0.5	0.6	-0.6
Reaction time premature initiation rate	0.8	1.2	2.1	-1.5	-0.8	1.0
Reaction time premature initiations	0.6	1.8	5.1	-2.3	-0.3	0.5
Std. dev. reaction times	0.2	0.6	0.8	0.2	-0.9	0.9
Reaction time trials completed	0.2	0.8	1.8	-1.3	0.6	-0.6
Reaction time trials AUC	0.2	0.6	1.4	-1.2	0.5	-0.5
Run reversals in cocaine runway, females	1.0	1.2	1.8	0.2	-1.3	1.3
Run reversals in cocaine runway, males	0.9	0.9	1.3	-0.9	0.9	-1.2
Latency to leave start box in cocaine runway	0.9	1.2	1.4	1.2	-1.1	1.0
Latency to leave start box in cocaine runway, F	0.7	0.9	1.1	0.8	-1.1	0.9
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.2	-0.2	0.3
Std. dev. time between licks in bursts	0.9	1.7	3.0	-1.7	1.1	-0.9
Total sessions with >9 infusions	0.4	0.5	1.0	0.5	-0.6	1.0
Short access day 1 total inactive lever presses	0.4	0.8	2.0	1.4	0.5	-0.5
Short access day 10 total inactive lever presses	0.0	0.0	0.0	0.2	-0.2	0.0
Short access day 1 total infusions	0.5	0.9	2.8	1.7	-0.1	0.2
Short access day 10 total infusions	1.9	3.2	3.8	1.9	-1.5	1.9
Short access total infusions	1.0	1.4	1.9	1.4	-0.9	1.3
Short access day 1 locomotion	0.4	0.7	1.9	1.4	0.0	0.4
Short access day 10 total locomotion	0.2	1.0	2.0	1.4	-0.4	0.9
Short access total locomotion	0.7	1.0	2.6	1.6	-0.2	0.7
One hour access (0.3 mA shock)	1.8	2.1	6.2	2.5	0.5	-0.2
Compulsive drug intake	1.1	1.7	4.8	-2.2	0.3	-0.4
One hour access (shock baseline)	1.2	3.1	8.7	3.0	0.7	-0.4
Social response proportion	0.5	0.6	0.9	0.2	-0.9	1.0
Social responses	0.2	0.2	0.6	-0.7	0.1	0.3
Social time	0.3	0.4	0.6	-0.7	-0.5	0.8
Soleus weight	1.8	5.3	7.0	1.5	2.6	-2.6
Bone: stiffness	1.5	2.7	4.5	0.6	-2.1	1.8
Tibialis anterior weight	3.4	11.7	34.2	-5.8	0.6	-0.8
Time to tail flick, vehicle, before self-admin	1.0	1.2	2.3	0.6	-1.5	1.0
Time to tail flick, vehicle, after self-admin	1.3	2.7	4.5	0.2	-1.9	2.1
Time to tail flick, test, before self-admin	2.0	2.3	3.4	1.8	-1.3	1.4
Time to tail flick, test, after self-admin	0.2	0.2	0.3	-0.4	0.2	-0.6
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.8	-0.3	-0.7	1.3
Delta time to tail flick, test, before/after SA	4.0	4.9	6.2	-2.5	1.9	-2.2
Tibia length	0.8	2.2	2.4	-1.5	1.4	-1.5
Ambulatory time before self-admin	0.2	0.7	1.0	0.5	-1.0	0.9
Ambulatory time after self-admin	0.5	0.8	1.8	1.3	-0.7	0.4
Bone: tissue strength	0.2	0.2	0.3	0.6	-0.4	0.3
Total heroin consumption	1.1	1.3	2.8	-1.7	-0.8	0.8
Bone: trabecular number	2.3	4.3	6.3	1.1	-2.5	2.3
Bone: trabecular spacing	0.5	0.8	1.5	-0.3	1.2	-0.9
Bone: trabecular thickness	1.3	1.8	2.1	1.4	-1.4	1.1
Bone: trabecular tissue density	2.8	4.8	6.8	1.0	2.6	-2.6
Water consumed over 24 hours	0.3	0.5	1.1	-0.3	-1.1	0.6
Number of responses in last shaping day	0.0	0.0	0.1	-0.1	0.2	0.3