Hub : Genes

Rps6kb2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain isoform ratio XR_005488929.2 0.02 0.02 3.5e-03 0.03 0.02 0.02 0.02 1.7e-03 4.8e-03 9.0e-03 2.9e-03
2 IC intron excision ratio chr1_210883738_210884130 0.11 0.08 4.3e-03 0.06 0.04 0.05 0.04 2.2e-03 7.4e-03 3.3e-03 7.2e-03
3 IC mRNA stability Rps6kb2 0.14 0.1 4.4e-03 0.04 0.01 0.02 0.02 1.1e-02 8.3e-02 6.4e-02 3.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density2.74.77.0-1.22.6-2.4
Area under the delay curve0.80.91.1-0.81.0-1.0
BMI with tail2.48.413.6-0.73.4-3.7
BMI without tail0.92.84.80.31.9-2.2
Body weight1.14.85.61.82.4-2.3
Weight adjusted by age0.30.51.31.10.2-0.2
Bone surface3.25.89.3-0.33.1-2.8
Bone volume2.13.75.8-0.82.4-2.2
Breakpoint value in progressive ratio session0.80.91.11.10.9-0.9
Number of licking bursts0.00.00.00.00.2-0.0
Context. condit. distance diff. score0.30.31.0-1.00.0-0.0
Locomotion velocity, session 10.00.00.0-0.00.1-0.1
Locomotion distance, session 11.62.02.9-0.61.7-1.6
Locomotion velocity, session 20.60.71.31.20.6-0.6
Locomotion distance, session 20.70.91.40.21.2-1.2
Locomotion velocity, session 31.82.02.5-1.11.5-1.6
Locomotion distance, session 30.20.20.4-0.30.4-0.6
Stereotopy head waving bouts, day 31.41.72.0-1.41.2-1.2
Stereotopy head waving duration, day 30.70.92.1-1.40.6-0.4
Locomotion velocity, session 71.31.41.9-0.91.2-1.4
Locomotion distance, session 70.30.40.60.10.7-0.8
Stereotopy head waving bouts, day 71.31.52.0-1.41.1-1.1
Stereotopy head waving duration, day 71.31.62.3-0.71.5-1.4
Locomotion velocity, session 80.40.51.01.00.7-0.4
Locomotion distance, session 80.20.30.6-0.80.5-0.5
Degree of sensitization distance0.50.50.7-0.10.9-0.8
Degree of sensitization stereotypy0.50.60.9-0.41.0-0.8
Conditioned locomotion2.12.55.72.4-0.91.0
Cocaine response after cond. corrected0.10.10.2-0.50.1-0.2
Cocaine response after cond. not corrected0.30.40.6-0.80.5-0.5
Cocaine response before conditioning0.10.10.2-0.10.4-0.2
Saline control response0.81.12.01.41.0-0.5
Bone: connectivity density3.55.59.1-0.43.0-2.7
Bone: cortical apparent density0.30.41.01.0-0.40.3
Bone: cortical area0.60.91.71.3-0.50.8
Bone: cortical porosity0.00.00.0-0.10.2-0.0
Bone: cortical porosity0.10.10.10.40.20.0
Bone: cortical thickness3.05.012.23.5-1.01.4
Bone: cortical thickness0.91.12.91.7-0.20.5
Bone: cortical tissue density0.40.51.31.1-0.40.2
Condit. Reinf. active minus inactive responses0.50.50.8-0.40.8-0.9
Condit. Reinf. active-inactive response ratio0.30.30.4-0.50.5-0.6
Condit. Reinf. active responses0.10.10.2-0.20.2-0.4
Condit. Reinf. inactive responses0.10.10.1-0.1-0.40.2
Incentive salience index mean0.30.40.6-0.20.7-0.8
Condit. Reinf. lever presses0.00.00.10.3-0.10.2
Condit. Reinf. active minus inactive responses1.31.72.4-1.61.0-1.3
Condit. Reinf. active-inactive response ratio1.01.13.0-1.70.3-0.5
Condit. Reinf. active responses1.72.42.9-1.41.5-1.7
Condit. Reinf. inactive responses1.11.42.2-0.11.5-1.4
Condit. Reinf. lever presses1.11.52.3-0.31.5-1.4
Condit. Reinf. lever reinforcers received1.92.63.5-1.21.7-1.9
Conditioned reinforcement - actives0.40.71.20.3-1.11.0
Conditioned reinforcement - inactives1.01.54.0-2.0-0.50.3
Conditioned locomotion2.93.84.6-2.0-2.11.7
Patch foraging indifference point 0 sec0.10.30.7-0.8-0.20.2
Patch foraging indifference point AUC0.71.02.71.6-0.50.1
Delay disc. indifference point, 0s delay1.61.82.2-1.31.2-1.5
Delay disc. indifference point, 16s delay0.30.41.0-1.0-0.10.1
Delay disc. indifference point, 2s delay0.50.61.1-1.00.5-0.6
Delay disc. indifference point, 24s delay0.30.30.50.5-0.50.7
Delay disc. indifference point, 4s delay0.60.61.1-0.30.8-1.0
Delay disc. indifference point, 8s delay0.30.40.6-0.50.8-0.5
Indifference point function ln k1.11.93.3-1.8-1.01.1
Indifference point function log k1.11.93.3-1.8-1.01.1
Patch foraging total patch changes 0 sec0.10.20.3-0.2-0.60.6
Patch foraging total patch changes 12 sec0.81.02.31.50.5-0.7
Patch foraging total patch changes 18 sec0.10.10.20.30.3-0.4
Patch foraging total patch changes 24 sec0.30.61.61.3-0.30.0
Patch foraging total patch changes 6 sec0.50.81.30.11.0-1.1
Patch foraging time to switch 0 sec1.73.66.4-0.62.5-2.0
Patch foraging water rate 0 sec3.06.210.70.2-3.32.8
Patch foraging water rate 12 sec3.36.911.6-0.3-3.43.0
Patch foraging water rate 18 sec0.71.11.7-0.2-1.21.3
Patch foraging water rate 24 sec2.94.06.20.4-2.52.4
Patch foraging water rate 6 sec2.43.55.30.6-2.32.2
Seeking ratio, delayed vs. immediate footshock0.81.01.4-0.71.2-1.0
Distance traveled before self-admin0.30.40.6-0.30.8-0.8
Distance traveled after self-admin0.00.00.1-0.10.30.1
Extensor digitorum longus weight2.07.720.94.61.2-0.9
Bone: elastic displacement2.73.23.81.5-1.91.9
Bone: elastic work1.41.84.62.1-0.50.8
Bone: endosteal estimation1.02.35.3-2.30.9-0.9
Bone: endosteal perimeter2.24.811.3-3.41.2-1.3
Epididymis fat weight1.34.57.3-2.7-1.71.8
Delta time in closed arm before/after self-admin0.60.61.71.3-0.0-0.0
Delta time in open arm before/after self-admin0.40.30.4-0.60.6-0.6
Diff in mean of infusions in LGA sessions0.30.30.91.00.00.2
Delay discount exponential model param0.60.70.90.6-0.90.9
Extinction: sum of active levers before priming1.11.22.00.41.4-1.2
Active lever presses in extinction session 60.50.51.51.20.1-0.3
Bone: final force0.40.70.90.81.0-0.7
Bone: final moment0.40.70.80.80.9-0.7
Food consumed during 24 hour testing period0.40.61.00.1-0.91.0
Glucose2.33.67.1-2.71.3-1.4
Heart weight1.42.12.9-1.71.4-1.2
Delay discount hyperbolic model param0.70.81.00.7-1.01.0
Intermittent access intake day 1-15 change0.81.72.5-1.1-1.21.6
Intermittent access intake escalation0.81.62.6-0.9-1.21.6
Intermittent access intake escalation 21.01.21.4-1.1-0.91.2
Intermitt. access day 1 inactive lever presses0.00.00.0-0.2-0.10.1
Intermitt. access day 15 inactive lever presses0.71.44.2-2.00.4-0.0
Intermitt. access escalation Index1.21.72.5-0.4-1.61.6
Intermittent access day 1 total infusions3.14.99.8-3.11.5-1.7
Intermittent access day 15 total infusions2.13.19.2-3.0-0.30.4
Intermittent access terminal intake (last 3 days)2.63.410.1-3.20.2-0.3
Intermittent access total infusions2.32.87.4-2.70.6-0.8
Intermittent access day 1 locomotion1.72.14.3-2.10.8-1.2
Intermittent access day 15 total locomotion1.32.47.2-2.7-0.20.1
Intermittent access total locomotion3.23.911.5-3.40.0-0.2
Intermittent access standard deviation0.20.41.2-1.1-0.20.2
Left kidney weight0.31.32.7-1.7-0.70.8
Right kidney weight0.31.52.4-0.8-1.21.5
Cocaine induced anxiety0.10.10.1-0.30.3-0.3
Post-drug Anxiety0.20.20.30.20.5-0.4
Baseline Anxiety0.10.20.50.70.10.0
Tail length0.62.35.32.3-0.80.9
Length with tail0.93.911.73.40.10.3
Length without tail0.82.57.42.70.30.0
Times rat made contact with spout0.60.61.2-0.11.1-0.8
Lifetime Intake1.62.05.2-2.30.5-0.8
Liver weight, left0.61.01.60.2-1.11.3
Liver weight, right0.61.11.8-0.4-1.21.3
Locomotor activity0.61.01.5-0.2-1.21.2
Locomotor testing distance0.61.11.6-0.2-1.31.3
Locomotor testing rearing0.20.30.9-1.00.0-0.2
Locomotion in novel chamber2.22.87.5-2.7-0.60.6
Locomotion in novel chamber post-restriction0.91.53.2-1.8-0.90.7
Fecal boli incidents, locomotor time 10.00.00.1-0.1-0.10.3
Change in fecal boli incidents, locomotor task0.10.10.2-0.10.4-0.3
Time >=10cm from walls, locomotor time 12.62.75.7-2.41.0-1.2
Bouts of movement, locomotor time 11.11.22.71.7-0.70.7
Total resting periods, locomotor time 10.91.01.71.3-0.80.7
Rest time, locomotor task time 11.21.52.3-0.5-1.41.5
Distance moved, locomotor task time 11.01.52.1-0.81.5-1.3
Vertical activity count, locomotor time 10.40.92.2-1.50.5-0.4
Time >=10cm from walls, locomotor time 20.10.20.4-0.0-0.60.4
Bouts of movement, locomotor time 20.10.20.50.70.1-0.2
Total resting periods, locomotor time 20.00.10.10.40.2-0.2
Rest time, locomotor task time 20.91.23.5-1.90.1-0.1
Distance moved, locomotor task time 20.60.71.81.4-0.40.5
Vertical activity count, locomotor time 21.72.32.41.5-1.51.5
Light reinforcement 10.20.50.8-0.3-0.90.9
Light reinforcement 20.81.21.6-0.8-1.31.1
Bone: marrow area1.12.45.6-2.40.9-0.9
Bone: maximum diameter0.10.20.5-0.1-0.40.7
Bone: maximum force1.83.25.3-0.22.3-2.1
Bone: maximum moment1.62.84.5-0.12.1-2.0
Mean time between licks in bursts0.10.20.50.70.1-0.3
Mean num. licks in bursts0.10.20.3-0.30.5-0.5
Cd content in liver0.50.61.5-1.2-0.40.3
Co content in liver1.82.13.30.8-1.81.5
Cu content in liver0.00.00.0-0.1-0.1-0.1
Fe content in liver0.10.10.10.40.0-0.3
K content in liver0.50.50.8-0.00.9-0.9
Mg content in liver0.40.40.8-0.90.4-0.4
Mn content in liver0.60.71.21.10.6-0.7
Na content in liver0.80.91.00.8-1.01.0
Rb content in liver1.11.22.7-1.60.8-0.7
Se content in liver0.40.50.8-0.90.6-0.6
Sr content in liver1.21.12.71.6-0.50.5
Zn content in liver0.30.30.80.9-0.30.4
Bone: minimum diameter1.62.84.9-2.21.4-1.2
Time in familiar zone, hab. session 10.40.40.8-0.90.4-0.5
Time in novel zone, hab. session 10.10.10.20.4-0.30.5
Total zone transitions, hab. session 10.20.20.50.40.7-0.3
Total locomotion distance, hab. session 10.20.20.7-0.80.10.1
Locomotion velocity, hab. session 10.00.10.1-0.40.10.1
Time in familiar zone, hab. session 20.60.71.51.2-0.50.5
Time in novel zone, hab. session 21.11.11.3-1.11.1-1.0
Total zone transitions, hab. session 23.95.07.5-1.02.7-2.6
Total locomotion distance, hab. session 21.41.82.2-1.21.5-1.4
Locomotion velocity, hab. session 21.31.71.8-1.41.3-1.3
Novel to familiar place preference ratio0.40.40.7-0.40.9-0.6
Novelty place preference0.40.40.6-0.60.8-0.5
Time in novel zone, NPP test0.40.40.7-0.60.8-0.5
Total zone transitions, NPP test1.11.62.40.01.5-1.6
Total locomotion distance, NPP test0.40.60.8-0.60.7-0.9
Locomotion velocity, NPP test0.20.30.5-0.50.5-0.7
Intraocular pressure1.01.52.20.4-1.51.5
Delta distance traveled before/after self-admin0.20.20.50.3-0.40.7
Delta ambulatory time before/after self-admin0.20.30.50.4-0.40.7
Parametrial fat weight0.92.16.3-2.5-0.30.1
Pavlov. Cond. lever latency0.20.20.3-0.4-0.50.6
Pavlov. Cond. magazine entry latency0.70.91.1-0.91.0-0.8
Pavlov. Cond. change in total contacts0.40.40.8-0.90.4-0.4
Pavlov. Cond. index score0.00.00.0-0.10.00.0
Pavlov. Cond. latency score0.10.10.1-0.20.3-0.3
Pavlov. Cond. lever contacts0.10.10.20.10.3-0.4
Pavlov. Cond. magazine entry number0.00.10.10.10.1-0.4
Pavlov. Cond. intertrial magazine entries0.50.61.00.4-1.00.8
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.10.1-0.1
Pavlov. Cond. response bias0.10.10.20.1-0.20.4
Pavlov. Cond. lever latency0.00.10.1-0.30.1-0.3
Pavlov. Cond. magazine entry latency2.32.84.80.42.2-1.8
Pavlov. Cond. change in total contacts0.50.81.3-0.51.1-1.0
Pavlov. Cond. index score0.60.81.60.11.3-0.9
Pavlov. Cond. latency score0.40.61.10.11.1-0.7
Pavlov. Cond. lever contacts0.00.00.00.20.10.2
Pavlov. Cond. magazine entry number2.63.25.3-0.5-2.32.0
Pavlov. Cond. intertrial magazine entries0.50.71.1-0.6-1.00.9
Pavlov. Cond. lever-magazine prob. diff.0.81.01.80.21.4-1.1
Pavlov. Cond. response bias0.60.81.70.11.3-0.9
Time in closed arm before self-admin0.70.92.2-1.50.4-0.6
Time in closed arm after self-admin0.00.00.1-0.0-0.30.1
Time in open arm before self-admin0.91.02.21.5-0.50.8
Time in open arm after self-admin0.20.20.30.50.6-0.4
Bone: periosteal estimation0.00.10.3-0.50.10.1
Bone: periosteal perimeter0.40.71.0-1.00.8-0.7
Bone: post-yield work8.312.113.4-3.23.6-3.7
Progressive ratio test 1 active lever presses0.10.10.2-0.4-0.3-0.3
Progressive ratio test 1 breakpoint0.10.10.1-0.3-0.3-0.2
Progressive ratio test 1 inactive lever presses0.10.10.2-0.4-0.1-0.4
Progressive ratio test 2 active lever presses0.91.13.2-1.8-0.2-0.2
Progressive ratio test 2 breakpoint0.81.02.8-1.7-0.2-0.1
Progressive ratio test 2 inactive lever presses2.33.810.8-3.3-0.60.4
Incentive Sensitization - Responses0.71.01.1-1.01.0-1.0
Incentive Sensitization - Breakpoint0.70.91.1-1.10.9-0.9
Sum of active levers in priming session hrs 5-64.13.84.41.6-2.12.1
Progressive ratio3.35.27.5-1.22.7-2.6
Food seeking constrained by brief footshock0.10.10.20.00.4-0.4
Seeking ratio, punishment vs. effort2.13.14.50.8-2.12.0
Retroperitoneal fat weight2.310.019.5-4.4-2.32.3
Reaction time number correct0.40.71.51.2-0.60.6
Reaction time mean minus median0.51.21.90.31.3-1.4
Reaction time mean minus median AUC0.20.50.70.80.6-0.8
Reaction time num false alarms0.81.21.40.9-1.21.1
Reaction time num false alarms AUC0.50.81.51.2-0.70.7
Reaction time trials correct on left0.40.71.51.2-0.60.6
Reaction time trials on left0.40.81.81.3-0.60.6
Reaction time mean0.30.50.7-0.80.8-0.5
Reaction time mean AUC0.40.71.0-1.00.8-0.6
Median of all reaction times0.50.81.4-1.20.8-0.5
Reaction time omissions0.40.60.70.90.7-0.8
Reaction time false alarm rate0.20.30.40.5-0.60.6
Reaction time premature initiation rate0.91.22.11.50.8-1.0
Reaction time premature initiations1.01.85.12.30.3-0.5
Std. dev. reaction times0.30.60.8-0.20.9-0.9
Reaction time trials completed0.40.81.81.3-0.60.6
Reaction time trials AUC0.30.61.41.2-0.50.5
Run reversals in cocaine runway, females1.21.21.8-0.21.3-1.3
Run reversals in cocaine runway, males0.90.91.30.9-0.91.2
Latency to leave start box in cocaine runway1.11.21.4-1.21.1-1.0
Latency to leave start box in cocaine runway, F0.80.91.1-0.81.1-0.9
Latency to leave start box in cocaine runway, M0.10.10.1-0.20.2-0.3
Std. dev. time between licks in bursts1.21.73.01.7-1.10.9
Total sessions with >9 infusions0.40.51.0-0.50.6-1.0
Short access day 1 total inactive lever presses0.60.82.0-1.4-0.50.5
Short access day 10 total inactive lever presses0.00.00.0-0.20.2-0.0
Short access day 1 total infusions0.70.92.8-1.70.1-0.2
Short access day 10 total infusions2.53.23.8-1.91.5-1.9
Short access total infusions1.11.41.9-1.40.9-1.3
Short access day 1 locomotion0.50.71.9-1.4-0.0-0.4
Short access day 10 total locomotion0.51.02.0-1.40.4-0.9
Short access total locomotion0.91.02.6-1.60.2-0.7
One hour access (0.3 mA shock)1.92.16.2-2.5-0.50.2
Compulsive drug intake1.41.74.82.2-0.30.4
One hour access (shock baseline)2.03.18.7-3.0-0.70.4
Social response proportion0.50.60.9-0.20.9-1.0
Social responses0.20.20.60.7-0.1-0.3
Social time0.30.40.60.70.5-0.8
Soleus weight1.85.37.0-1.5-2.62.6
Bone: stiffness1.72.74.5-0.62.1-1.8
Tibialis anterior weight3.511.734.25.8-0.60.8
Time to tail flick, vehicle, before self-admin1.21.22.3-0.61.5-1.0
Time to tail flick, vehicle, after self-admin2.02.74.5-0.21.9-2.1
Time to tail flick, test, before self-admin2.32.33.4-1.81.3-1.4
Time to tail flick, test, after self-admin0.20.20.30.4-0.20.6
Delta time to tail flick, vehicle, before/after SA0.80.81.80.30.7-1.3
Delta time to tail flick, test, before/after SA4.84.96.22.5-1.92.2
Tibia length0.82.22.41.5-1.41.5
Ambulatory time before self-admin0.40.71.0-0.51.0-0.9
Ambulatory time after self-admin0.70.81.8-1.30.7-0.4
Bone: tissue strength0.20.20.3-0.60.4-0.3
Total heroin consumption1.11.32.81.70.8-0.8
Bone: trabecular number2.64.36.3-1.12.5-2.3
Bone: trabecular spacing0.60.81.50.3-1.20.9
Bone: trabecular thickness1.41.82.1-1.41.4-1.1
Bone: trabecular tissue density3.34.86.8-1.0-2.62.6
Water consumed over 24 hours0.40.51.10.31.1-0.6
Number of responses in last shaping day0.00.00.10.1-0.2-0.3