Hub : Genes

Prss55

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL intron excision ratio chr15_42516068_42520826 0.05 0.03 1.1e-05 0.04 0.04 0.04 0.04 5.1e-05 2.4e-05 4.0e-05 9.2e-05
2 Brain intron excision ratio chr15_42516068_42520826 0.07 0.04 1.1e-06 0.06 0.07 0.05 0.05 4.0e-06 9.5e-07 1.3e-05 3.3e-05
3 BLA mRNA stability Prss55 0.07 0.05 2.8e-03 0.02 0.02 0.02 0.02 2.5e-02 2.3e-02 3.6e-02 4.8e-02
4 Brain gene expression Prss55 0.15 0.07 2.0e-12 0.14 0.14 0.14 0.14 1.0e-12 2.3e-13 1.4e-12 6.2e-13
5 pVTA intron excision ratio chr15_42516068_42520826 0.04 0.03 2.4e-03 0.03 0.04 0.02 0.03 1.1e-03 6.7e-04 6.5e-03 2.2e-03
6 Brain intron excision ratio chr15_42495020_42520826 0.06 0.04 1.1e-04 0.03 0.04 0.04 0.04 1.2e-03 5.6e-05 1.1e-04 5.1e-05
7 NAcc intron excision ratio chr15_42516068_42520826 0.03 0.02 1.8e-05 0.03 0.02 0.02 0.02 7.8e-05 4.1e-04 3.7e-04 3.0e-04
8 NAcc gene expression Prss55 0.16 0.07 1.7e-16 0.1 0.11 0.09 0.1 8.0e-15 3.5e-16 6.0e-14 4.2e-15
9 BLA gene expression Prss55 0.38 0.12 0.0e+00 0.29 0.29 0.3 0.26 6.4e-16 7.0e-16 1.4e-16 5.9e-14
10 PL gene expression Prss55 0.15 0.08 1.0e-11 0.1 0.09 0.08 0.1 2.4e-11 3.5e-10 2.9e-09 4.6e-11
11 IC gene expression Prss55 0.25 0.11 4.1e-08 0.14 0.15 0.15 0.15 2.2e-06 5.4e-07 6.8e-07 7.1e-07
12 BLA intron excision ratio chr15_42516068_42520826 0.06 0.04 6.4e-03 0.01 0.01 0.01 0.01 1.3e-01 1.3e-01 1.2e-01 1.5e-01
13 Adipose gene expression Prss55 0.1 0.09 5.1e-06 0.04 0.03 0.01 0.03 2.7e-05 4.1e-04 8.9e-03 1.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.61.13.30.60.70.31.51.6-0.5-0.51.6-0.6-1.01.8-1.00.2
Area under the delay curve5.17.811.4-2.9-2.8-2.2-3.1-3.42.72.4-3.13.22.8-3.32.7-0.7
BMI with tail0.72.54.9-1.8-1.6-1.7-1.4-1.61.82.2-1.12.01.1-1.21.4-0.9
BMI without tail0.00.10.30.10.1-0.00.20.30.30.30.4-0.1-0.50.4-0.5-0.2
Body weight1.15.08.4-2.6-2.6-2.9-2.0-1.92.72.9-1.52.21.9-1.21.8-2.1
Weight adjusted by age0.51.53.7-1.3-1.4-1.8-0.9-0.51.61.5-0.50.70.9-0.01.3-1.9
Bone surface0.40.72.40.40.50.21.31.3-0.4-0.31.3-0.6-0.71.6-0.60.1
Bone volume0.20.31.10.10.2-0.00.90.8-0.10.11.0-0.2-0.51.1-0.20.4
Breakpoint value in progressive ratio session0.61.12.0-1.1-1.1-0.7-1.3-1.20.80.9-1.40.91.0-1.41.3-0.0
Number of licking bursts0.10.41.1-0.4-0.4-0.1-0.8-0.80.50.1-1.10.70.5-1.10.50.2
Context. condit. distance diff. score1.11.47.11.01.21.50.70.0-1.5-0.60.7-0.4-1.0-0.2-1.12.7
Locomotion velocity, session 10.20.30.6-0.8-0.7-0.7-0.3-0.20.60.6-0.40.50.5-0.10.5-0.0
Locomotion distance, session 10.10.10.2-0.4-0.4-0.40.20.50.10.30.2-0.10.10.5-0.10.2
Locomotion velocity, session 20.50.61.5-1.2-1.0-0.9-0.4-0.40.71.1-0.51.20.8-0.30.30.3
Locomotion distance, session 20.30.41.6-0.2-0.2-0.30.81.20.10.10.7-0.2-0.31.2-0.4-0.1
Locomotion velocity, session 30.60.71.8-1.0-1.1-1.2-0.9-0.50.80.5-0.80.70.9-0.40.4-1.3
Locomotion distance, session 30.30.30.6-0.7-0.7-0.6-0.8-0.60.40.4-0.70.40.5-0.70.4-0.2
Stereotopy head waving bouts, day 30.70.81.71.10.80.60.71.1-0.6-1.30.6-1.1-0.70.9-0.7-1.0
Stereotopy head waving duration, day 30.20.32.30.0-0.2-0.3-0.30.10.3-0.4-0.5-0.10.4-0.00.3-1.5
Locomotion velocity, session 71.11.24.70.50.81.01.00.7-1.4-0.31.1-0.3-1.20.6-1.72.2
Locomotion distance, session 72.02.65.51.51.71.91.61.2-1.8-1.21.5-1.2-1.71.0-1.62.3
Stereotopy head waving bouts, day 71.31.52.5-1.4-1.5-1.6-1.1-0.81.41.2-1.01.01.2-0.61.1-1.6
Stereotopy head waving duration, day 71.92.34.7-1.6-1.7-1.9-1.6-1.21.51.3-1.41.11.6-1.01.2-2.2
Locomotion velocity, session 80.20.30.5-0.7-0.6-0.4-0.4-0.50.30.6-0.40.70.7-0.50.30.5
Locomotion distance, session 80.30.42.60.20.40.50.70.5-0.7-0.10.50.0-0.60.4-0.81.6
Degree of sensitization distance4.95.38.22.42.62.82.51.9-2.4-1.92.2-1.8-2.51.6-2.22.9
Degree of sensitization stereotypy1.82.02.9-1.7-1.7-1.6-1.5-1.41.31.6-1.31.31.4-1.21.3-0.7
Conditioned locomotion0.50.61.40.80.90.90.60.1-0.9-0.20.7-0.6-1.00.2-0.61.2
Cocaine response after cond. corrected0.50.72.60.60.81.1-0.5-1.2-1.0-0.2-0.4-0.1-0.2-1.40.01.6
Cocaine response after cond. not corrected0.40.61.80.50.60.9-0.6-1.1-0.7-0.2-0.5-0.1-0.0-1.30.21.3
Cocaine response before conditioning0.30.41.2-0.7-0.7-0.9-0.10.31.00.4-0.10.20.40.40.6-1.1
Saline control response0.10.20.50.20.00.00.10.60.1-0.7-0.2-0.50.30.30.3-0.7
Bone: connectivity density2.13.37.51.61.50.92.32.5-1.2-1.42.4-1.5-1.72.7-2.0-0.3
Bone: cortical apparent density0.30.41.70.0-0.10.1-1.0-1.1-0.30.0-0.90.10.6-1.30.1-0.2
Bone: cortical area0.91.52.3-1.3-1.2-0.9-1.4-1.50.91.2-1.41.31.2-1.51.30.4
Bone: cortical porosity2.32.54.1-1.6-1.6-1.5-1.6-1.61.81.6-1.51.81.4-1.42.0-0.7
Bone: cortical porosity1.82.03.6-1.5-1.5-1.5-1.4-1.31.61.3-1.31.51.2-1.11.9-0.9
Bone: cortical thickness1.72.95.2-1.7-1.7-1.1-2.0-2.11.11.5-2.21.81.8-2.31.40.3
Bone: cortical thickness2.12.56.2-1.4-1.2-0.4-1.7-2.10.61.2-2.02.01.5-2.50.91.8
Bone: cortical tissue density0.20.31.40.10.10.2-0.9-1.0-0.4-0.1-0.80.00.5-1.20.0-0.2
Condit. Reinf. active minus inactive responses0.40.41.1-1.0-1.0-1.1-0.30.10.60.9-0.20.50.50.20.4-0.5
Condit. Reinf. active-inactive response ratio0.10.10.20.40.30.20.20.4-0.4-0.50.2-0.4-0.20.3-0.3-0.2
Condit. Reinf. active responses0.60.71.6-1.2-1.2-1.3-0.6-0.21.01.1-0.50.80.7-0.10.8-0.6
Condit. Reinf. inactive responses0.30.40.8-0.9-0.9-0.9-0.5-0.30.90.8-0.40.40.6-0.20.8-0.6
Incentive salience index mean2.22.94.8-2.2-2.2-2.2-1.3-1.02.02.1-1.21.91.6-0.71.6-1.1
Condit. Reinf. lever presses3.35.08.4-2.7-2.6-2.6-1.8-1.62.92.7-1.62.62.0-1.22.3-1.2
Condit. Reinf. active minus inactive responses0.30.40.70.60.60.80.60.5-0.7-0.70.3-0.3-0.50.3-0.80.8
Condit. Reinf. active-inactive response ratio0.10.10.60.20.20.30.40.5-0.4-0.50.20.1-0.30.3-0.80.3
Condit. Reinf. active responses0.30.40.90.70.70.80.70.6-0.5-0.50.6-0.5-0.60.5-0.71.0
Condit. Reinf. inactive responses0.60.91.31.01.11.11.10.9-0.8-0.71.0-1.1-1.00.8-0.71.1
Condit. Reinf. lever presses0.30.41.4-0.3-0.3-0.70.60.90.80.30.60.2-0.01.2-0.2-0.9
Condit. Reinf. lever reinforcers received0.10.20.40.40.40.50.50.4-0.2-0.30.3-0.2-0.30.3-0.40.7
Conditioned reinforcement - actives1.56.18.32.92.92.72.62.3-2.6-2.52.5-2.7-2.42.1-2.01.9
Conditioned reinforcement - inactives0.82.13.81.71.51.31.61.9-1.4-1.51.4-1.7-1.11.7-1.3-0.0
Conditioned locomotion1.42.15.91.71.72.10.70.2-1.7-1.90.5-1.2-1.3-0.2-1.12.4
Patch foraging indifference point 0 sec0.10.31.2-0.3-0.4-0.70.10.40.60.50.2-0.00.40.60.1-1.1
Patch foraging indifference point AUC0.30.72.80.70.71.20.1-0.1-1.2-0.8-0.2-0.1-0.5-0.6-1.01.7
Delay disc. indifference point, 0s delay0.10.10.4-0.3-0.2-0.2-0.2-0.40.60.1-0.10.40.2-0.20.6-0.1
Delay disc. indifference point, 16s delay2.84.08.2-1.9-1.8-1.3-2.5-2.71.31.7-2.52.01.8-2.91.80.0
Delay disc. indifference point, 2s delay0.80.91.4-1.0-0.9-0.8-0.9-1.01.20.8-0.91.21.0-0.91.1-0.5
Delay disc. indifference point, 24s delay2.94.79.2-2.2-2.0-1.3-2.5-2.91.71.9-2.62.71.7-3.01.70.4
Delay disc. indifference point, 4s delay5.76.17.0-2.6-2.6-2.3-2.6-2.62.62.2-2.62.72.6-2.42.6-1.5
Delay disc. indifference point, 8s delay4.57.610.7-2.9-2.7-2.3-3.1-3.32.82.5-3.03.02.7-3.22.7-0.9
Indifference point function ln k0.51.52.9-1.3-1.3-1.7-0.8-0.81.71.6-0.50.91.2-0.21.6-1.5
Indifference point function log k0.51.52.9-1.3-1.3-1.7-0.8-0.81.71.6-0.50.91.2-0.21.6-1.5
Patch foraging total patch changes 0 sec0.20.61.7-0.7-0.8-1.0-0.4-0.11.00.9-0.30.40.90.10.6-1.3
Patch foraging total patch changes 12 sec0.10.10.3-0.5-0.5-0.3-0.30.00.00.2-0.50.30.4-0.2-0.20.2
Patch foraging total patch changes 18 sec0.20.51.20.70.81.00.40.2-1.0-0.50.3-0.7-0.5-0.0-1.11.1
Patch foraging total patch changes 24 sec0.00.00.00.00.00.1-0.00.10.1-0.1-0.2-0.10.2-0.00.0-0.1
Patch foraging total patch changes 6 sec0.00.00.20.00.00.1-0.10.2-0.1-0.1-0.20.10.3-0.0-0.50.1
Patch foraging time to switch 0 sec0.00.10.20.10.20.30.40.40.0-0.10.3-0.0-0.20.3-0.20.2
Patch foraging water rate 0 sec0.31.11.6-1.1-1.2-1.3-1.3-1.20.81.1-1.10.71.2-1.00.9-0.9
Patch foraging water rate 12 sec0.20.82.0-0.8-0.8-0.9-0.8-0.81.10.8-0.70.41.0-0.61.4-0.8
Patch foraging water rate 18 sec1.53.54.4-1.8-1.9-2.0-2.0-2.02.11.6-1.81.52.0-1.62.1-1.6
Patch foraging water rate 24 sec0.20.30.7-0.6-0.5-0.5-0.4-0.60.20.8-0.20.20.5-0.40.80.5
Patch foraging water rate 6 sec0.71.11.7-0.8-0.9-1.1-1.3-1.20.90.9-1.10.21.2-0.91.3-1.3
Seeking ratio, delayed vs. immediate footshock0.10.10.6-0.20.0-0.30.1-0.20.10.80.6-0.2-0.40.3-0.10.1
Distance traveled before self-admin0.10.20.50.50.4-0.10.30.20.2-0.30.5-0.7-0.10.5-0.4-0.7
Distance traveled after self-admin0.40.71.8-0.6-0.5-0.7-0.9-1.30.80.7-0.60.50.8-1.00.9-0.6
Extensor digitorum longus weight6.927.733.2-5.4-5.4-5.3-5.8-5.65.35.4-5.34.85.7-5.05.5-3.6
Bone: elastic displacement0.30.41.30.80.60.70.60.8-0.6-1.10.3-1.0-0.50.5-0.10.1
Bone: elastic work0.20.30.7-0.5-0.6-0.6-0.4-0.10.40.2-0.60.10.5-0.20.9-0.7
Bone: endosteal estimation0.10.31.00.20.2-0.00.80.8-0.1-0.10.9-0.5-0.71.0-0.2-0.0
Bone: endosteal perimeter0.51.22.70.90.90.51.41.4-0.7-0.71.6-1.2-1.31.7-0.70.1
Epididymis fat weight0.10.31.2-0.2-0.20.1-0.7-0.9-0.30.1-0.80.20.2-1.10.40.5
Delta time in closed arm before/after self-admin0.10.10.6-0.10.1-0.10.4-0.00.10.60.70.1-0.40.4-0.20.2
Delta time in open arm before/after self-admin0.10.10.40.0-0.2-0.0-0.4-0.10.0-0.5-0.70.10.6-0.4-0.1-0.6
Diff in mean of infusions in LGA sessions2.03.65.5-2.3-2.3-2.3-2.1-1.51.91.8-2.01.71.8-1.41.4-1.7
Delay discount exponential model param6.79.112.73.23.02.53.33.6-2.9-2.63.3-3.5-3.03.5-2.90.9
Extinction: sum of active levers before priming0.10.10.3-0.2-0.2-0.1-0.5-0.40.20.0-0.6-0.00.4-0.50.6-0.2
Active lever presses in extinction session 60.10.10.60.30.40.50.30.20.3-0.20.2-0.1-0.40.1-0.40.8
Bone: final force1.22.03.4-1.8-1.6-1.5-1.4-1.51.21.8-1.21.61.4-1.31.2-0.0
Bone: final moment1.01.62.6-1.6-1.5-1.5-1.2-1.31.21.6-1.01.31.2-1.01.2-0.4
Food consumed during 24 hour testing period0.00.10.5-0.0-0.1-0.30.10.30.2-0.20.2-0.30.30.40.3-0.7
Glucose0.20.41.0-0.4-0.4-0.0-0.6-0.50.3-0.2-1.00.90.6-0.90.50.6
Heart weight0.30.40.70.70.70.60.60.4-0.7-0.50.7-0.7-0.90.5-0.70.5
Delay discount hyperbolic model param6.17.910.82.92.82.33.13.2-2.8-2.43.1-3.3-2.83.2-2.80.9
Intermittent access intake day 1-15 change0.31.82.51.51.51.51.51.4-1.3-1.31.3-1.3-1.21.2-1.60.8
Intermittent access intake escalation0.20.91.51.11.01.11.01.1-0.8-1.00.9-0.8-0.90.9-1.20.6
Intermittent access intake escalation 20.30.50.90.90.80.90.70.7-0.4-0.90.5-0.6-0.60.5-0.90.3
Intermitt. access day 1 inactive lever presses0.10.82.20.80.80.51.01.1-0.6-0.51.2-0.7-0.81.2-1.50.1
Intermitt. access day 15 inactive lever presses0.10.42.50.20.0-0.40.40.60.6-0.00.50.00.20.90.0-1.6
Intermitt. access escalation Index0.00.10.30.10.20.20.40.3-0.10.10.4-0.1-0.40.3-0.30.5
Intermittent access day 1 total infusions0.20.51.40.90.91.20.50.3-0.9-1.00.2-0.7-0.4-0.00.10.9
Intermittent access day 15 total infusions0.92.23.91.71.82.01.51.5-1.5-1.71.2-1.4-1.31.0-1.21.4
Intermittent access terminal intake (last 3 days)1.32.34.41.81.82.11.51.5-1.6-1.91.1-1.4-1.10.9-1.31.3
Intermittent access total infusions2.02.44.81.81.92.21.51.2-1.7-1.71.1-1.4-1.20.7-1.31.7
Intermittent access day 1 locomotion0.20.30.9-0.3-0.3-0.1-0.6-0.60.40.1-0.80.20.7-0.80.9-0.2
Intermittent access day 15 total locomotion0.31.12.71.41.31.50.70.7-1.1-1.70.3-1.1-0.70.2-0.70.9
Intermittent access total locomotion0.20.20.70.70.70.80.30.2-0.4-0.9-0.0-0.4-0.1-0.1-0.10.4
Intermittent access standard deviation0.21.11.71.11.01.31.11.3-1.2-1.30.7-1.0-0.90.8-0.90.8
Left kidney weight0.32.86.5-1.9-2.0-2.6-1.2-0.92.02.0-0.61.31.5-0.11.0-2.6
Right kidney weight0.74.912.8-2.4-2.5-3.3-1.6-1.22.62.8-0.71.51.9-0.21.5-3.6
Cocaine induced anxiety0.61.73.0-1.6-1.5-1.5-1.2-1.21.11.7-1.01.11.3-0.91.4-1.0
Post-drug Anxiety0.91.03.1-1.1-1.1-1.4-0.7-0.51.11.3-0.50.60.9-0.10.9-1.7
Baseline Anxiety0.10.10.30.30.10.10.20.40.2-0.50.1-0.1-0.30.3-0.1-0.5
Tail length0.21.02.40.70.60.11.01.4-0.3-0.81.1-1.4-0.71.6-1.0-1.1
Length with tail0.20.93.3-1.0-1.2-1.6-0.5-0.11.10.8-0.20.20.80.40.4-1.8
Length without tail1.26.29.4-2.9-2.9-3.1-2.5-2.32.52.4-2.22.42.6-1.82.4-2.0
Times rat made contact with spout0.10.20.4-0.4-0.3-0.40.30.30.70.40.30.60.10.50.10.3
Lifetime Intake1.82.24.51.81.82.11.51.3-1.6-1.71.1-1.4-1.20.8-1.11.5
Liver weight, left0.91.63.9-1.2-1.3-1.6-1.2-0.81.41.1-0.90.61.4-0.51.4-2.0
Liver weight, right1.12.04.0-1.2-1.3-1.1-1.9-1.70.50.8-2.01.11.8-1.90.9-1.0
Locomotor activity2.53.97.5-2.2-2.3-2.7-1.7-1.32.22.2-1.41.31.8-0.71.8-2.7
Locomotor testing distance0.20.52.9-0.5-0.6-1.00.20.60.50.50.4-0.50.21.00.2-1.7
Locomotor testing rearing0.51.86.80.20.0-0.71.42.20.1-0.31.6-1.3-0.72.6-0.5-2.0
Locomotion in novel chamber0.40.51.3-0.8-0.8-0.9-0.6-0.40.81.1-0.50.50.5-0.30.3-0.8
Locomotion in novel chamber post-restriction0.10.41.0-0.9-0.8-0.5-0.5-0.30.30.8-0.60.70.1-0.50.01.0
Fecal boli incidents, locomotor time 10.00.10.4-0.1-0.1-0.0-0.1-0.4-0.20.0-0.00.2-0.2-0.30.40.6
Change in fecal boli incidents, locomotor task0.20.20.60.20.1-0.10.30.7-0.1-0.30.2-0.20.10.6-0.8-0.5
Time >=10cm from walls, locomotor time 10.30.31.20.0-0.1-0.50.40.8-0.00.00.6-0.6-0.31.1-0.5-0.9
Bouts of movement, locomotor time 10.20.31.0-0.9-0.7-0.6-0.1-0.20.80.9-0.01.00.2-0.00.00.0
Total resting periods, locomotor time 10.20.20.9-0.6-0.4-0.1-0.0-0.30.40.6-0.00.9-0.1-0.2-0.30.7
Rest time, locomotor task time 10.20.31.1-0.6-0.3-0.0-0.0-0.20.20.80.00.9-0.1-0.3-0.61.0
Distance moved, locomotor task time 10.10.41.40.80.70.50.40.6-0.8-0.90.3-1.2-0.50.4-0.2-0.3
Vertical activity count, locomotor time 10.10.52.20.50.1-0.0-0.4-0.1-0.0-0.8-0.5-1.10.2-0.21.2-1.5
Time >=10cm from walls, locomotor time 20.10.41.30.20.1-0.40.40.5-0.4-0.10.8-0.9-0.40.9-0.5-1.1
Bouts of movement, locomotor time 20.82.74.5-1.8-1.8-1.4-1.8-1.91.21.5-1.82.11.7-1.81.1-0.4
Total resting periods, locomotor time 20.93.56.2-2.1-2.1-1.7-2.0-2.11.51.7-2.12.52.0-2.11.3-0.4
Rest time, locomotor task time 21.32.24.3-1.8-1.6-0.9-1.5-1.51.01.4-1.82.11.3-1.80.60.9
Distance moved, locomotor task time 20.50.72.21.11.00.60.60.6-0.7-0.90.8-1.5-0.70.7-0.1-0.6
Vertical activity count, locomotor time 20.20.51.81.00.80.5-0.0-0.2-0.5-0.80.1-1.3-0.2-0.11.1-0.8
Light reinforcement 10.10.31.0-0.7-0.6-0.7-0.2-0.21.00.6-0.20.80.4-0.00.4-0.6
Light reinforcement 20.10.20.50.60.70.70.3-0.1-0.6-0.40.3-0.3-0.5-0.1-0.30.5
Bone: marrow area0.10.41.10.20.30.10.80.8-0.2-0.21.0-0.6-0.81.0-0.20.1
Bone: maximum diameter0.20.51.2-0.6-0.5-0.2-0.8-0.90.20.4-0.90.50.6-1.10.80.6
Bone: maximum force1.32.63.7-1.9-1.8-1.6-1.7-1.81.31.8-1.61.71.6-1.61.70.0
Bone: maximum moment1.22.23.2-1.8-1.7-1.6-1.5-1.51.41.6-1.41.51.5-1.31.7-0.4
Mean time between licks in bursts0.84.87.12.42.31.82.42.3-2.0-1.92.7-2.6-2.42.5-2.00.4
Mean num. licks in bursts0.20.51.60.20.3-0.01.00.9-0.20.11.3-0.4-0.51.3-0.50.2
Cd content in liver0.50.63.6-0.5-0.7-1.10.00.60.6-0.10.1-0.10.50.80.1-1.9
Co content in liver1.41.73.0-1.4-1.3-1.1-1.2-1.41.21.4-1.21.51.2-1.31.70.0
Cu content in liver1.01.22.4-1.4-1.3-1.4-0.6-0.61.41.5-0.41.40.9-0.20.9-0.6
Fe content in liver1.21.52.41.21.21.01.41.5-1.0-1.51.2-1.3-1.11.4-1.10.0
K content in liver0.30.30.60.80.80.70.50.3-0.4-0.50.6-0.3-0.60.3-0.30.5
Mg content in liver2.02.23.01.61.61.41.71.6-1.2-1.41.7-1.4-1.61.6-1.40.9
Mn content in liver1.01.11.71.21.31.21.20.9-0.9-0.71.2-1.1-1.30.9-0.61.1
Na content in liver5.66.39.1-2.6-2.7-2.7-2.4-1.93.02.2-2.52.62.8-1.72.4-2.6
Rb content in liver1.41.62.61.41.30.91.31.5-0.9-1.61.3-1.5-1.11.5-1.2-0.1
Se content in liver0.10.20.50.20.2-0.00.30.50.3-0.10.4-0.5-0.20.60.5-0.7
Sr content in liver1.00.92.20.80.70.41.21.4-0.4-0.81.1-0.8-0.91.5-1.0-0.6
Zn content in liver0.60.82.20.70.70.41.21.3-0.1-0.61.3-0.6-0.91.5-0.4-0.1
Bone: minimum diameter0.30.61.0-1.0-0.9-0.7-0.7-0.70.70.9-0.70.90.6-0.60.80.2
Time in familiar zone, hab. session 10.20.21.50.20.30.60.2-0.1-0.3-0.00.1-0.1-0.4-0.20.11.2
Time in novel zone, hab. session 10.70.81.8-0.8-0.9-0.8-1.2-0.80.60.2-1.30.71.2-1.00.4-1.1
Total zone transitions, hab. session 10.40.60.9-1.0-0.9-0.6-0.9-0.80.40.9-0.90.50.9-0.90.50.3
Total locomotion distance, hab. session 10.00.10.4-0.2-0.10.1-0.10.0-0.20.0-0.2-0.10.1-0.2-0.30.6
Locomotion velocity, hab. session 10.00.10.2-0.4-0.4-0.3-0.10.00.20.3-0.10.00.30.00.10.2
Time in familiar zone, hab. session 20.20.30.60.70.70.70.20.0-0.6-0.70.2-0.5-0.4-0.10.00.7
Time in novel zone, hab. session 20.10.10.3-0.5-0.5-0.4-0.00.20.20.3-0.20.40.20.2-0.3-0.2
Total zone transitions, hab. session 20.60.81.8-1.2-1.1-1.2-0.6-0.61.11.3-0.40.60.7-0.31.1-0.4
Total locomotion distance, hab. session 20.30.41.4-0.9-0.8-0.8-0.4-0.50.91.2-0.20.50.3-0.30.70.2
Locomotion velocity, hab. session 20.70.92.1-1.3-1.1-1.1-0.7-0.71.21.5-0.50.90.6-0.51.0-0.0
Novel to familiar place preference ratio0.30.41.30.30.30.50.80.9-0.6-0.40.40.1-0.60.6-1.11.1
Novelty place preference0.30.41.20.10.20.30.81.0-0.4-0.20.60.2-0.70.8-1.11.0
Time in novel zone, NPP test0.30.31.10.00.10.20.70.9-0.3-0.20.50.2-0.50.8-1.00.7
Total zone transitions, NPP test0.20.21.3-0.7-0.5-0.60.1-0.00.51.10.30.3-0.00.30.40.3
Total locomotion distance, NPP test1.11.53.20.80.90.61.61.6-0.8-0.31.7-1.1-1.51.8-1.10.9
Locomotion velocity, NPP test1.11.53.00.80.90.71.61.6-0.9-0.31.7-1.1-1.61.7-1.11.0
Intraocular pressure3.96.411.22.72.42.32.83.1-2.5-3.32.2-2.4-2.32.7-2.51.0
Delta distance traveled before/after self-admin1.01.11.9-1.0-1.0-0.7-1.2-1.30.80.5-1.41.21.1-1.41.2-0.2
Delta ambulatory time before/after self-admin0.40.61.5-0.6-0.7-0.3-1.0-1.00.50.1-1.20.80.8-1.21.00.1
Parametrial fat weight1.53.45.41.81.92.01.91.8-1.9-1.51.8-1.9-1.91.5-1.62.3
Pavlov. Cond. lever latency2.12.74.81.91.81.81.31.4-2.2-2.11.1-2.2-1.51.0-1.70.5
Pavlov. Cond. magazine entry latency0.70.91.6-1.1-1.1-1.2-0.7-0.61.31.0-0.71.20.9-0.30.7-1.0
Pavlov. Cond. change in total contacts4.14.46.2-2.5-2.5-2.3-1.9-1.72.52.1-1.92.52.2-1.52.0-0.9
Pavlov. Cond. index score4.55.78.8-2.7-2.7-2.7-2.1-2.03.02.7-1.82.92.3-1.52.4-1.5
Pavlov. Cond. latency score3.54.47.2-2.5-2.4-2.5-1.8-1.72.72.5-1.52.62.0-1.22.1-1.2
Pavlov. Cond. lever contacts2.73.35.8-2.1-2.0-2.1-1.4-1.52.42.3-1.12.41.6-1.01.9-0.7
Pavlov. Cond. magazine entry number2.73.45.42.12.12.11.71.5-2.3-1.91.5-2.1-1.81.1-1.81.6
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.1-0.1-0.30.0-0.0-0.00.40.2-0.3-0.10.20.0-0.2
Pavlov. Cond. lever-magazine prob. diff.5.16.39.8-2.8-2.8-2.9-2.3-2.23.12.8-2.03.02.5-1.72.5-1.6
Pavlov. Cond. response bias3.24.06.0-2.2-2.2-2.2-1.8-1.82.42.2-1.62.41.9-1.42.0-1.3
Pavlov. Cond. lever latency0.81.14.01.01.21.50.4-0.1-1.6-0.70.4-0.7-1.0-0.4-0.62.0
Pavlov. Cond. magazine entry latency1.42.02.7-1.5-1.6-1.6-1.5-1.41.61.5-1.41.21.5-1.21.4-1.2
Pavlov. Cond. change in total contacts1.02.45.9-1.5-1.7-1.9-1.6-1.01.91.2-1.50.91.8-0.81.1-2.4
Pavlov. Cond. index score1.42.34.7-1.5-1.7-1.9-1.3-0.92.01.3-1.31.21.6-0.71.3-2.2
Pavlov. Cond. latency score1.42.25.0-1.5-1.6-1.9-1.3-0.92.01.3-1.21.11.5-0.61.3-2.2
Pavlov. Cond. lever contacts0.81.14.1-1.0-1.2-1.5-0.50.11.70.8-0.50.71.00.40.7-2.0
Pavlov. Cond. magazine entry number0.70.91.41.11.01.01.00.9-1.2-1.10.9-0.9-0.90.8-0.90.6
Pavlov. Cond. intertrial magazine entries4.39.513.52.93.02.73.73.6-2.9-2.83.6-2.8-3.33.5-2.92.1
Pavlov. Cond. lever-magazine prob. diff.1.62.44.1-1.6-1.7-1.8-1.5-1.12.01.4-1.51.31.7-0.91.3-2.0
Pavlov. Cond. response bias1.31.93.5-1.5-1.6-1.8-1.1-0.61.91.3-1.11.11.4-0.41.1-1.9
Time in closed arm before self-admin0.91.62.7-1.3-1.3-1.5-1.2-1.21.41.4-0.91.31.3-0.80.8-1.6
Time in closed arm after self-admin0.80.93.7-1.2-0.9-1.3-0.6-1.11.01.90.21.00.3-0.30.7-0.4
Time in open arm before self-admin0.80.91.40.90.90.81.11.2-1.0-0.80.9-1.2-1.11.0-0.51.0
Time in open arm after self-admin0.40.41.00.70.50.40.61.0-0.6-1.00.3-0.7-0.30.7-0.7-0.4
Bone: periosteal estimation0.00.10.3-0.5-0.4-0.3-0.2-0.30.30.5-0.10.20.1-0.20.50.3
Bone: periosteal perimeter0.00.00.1-0.2-0.1-0.20.10.10.10.20.20.0-0.20.20.30.3
Bone: post-yield work0.71.37.8-0.20.10.9-0.7-1.4-0.60.1-0.90.70.3-1.90.22.8
Progressive ratio test 1 active lever presses0.30.61.40.80.81.20.60.7-1.1-1.00.2-0.6-0.40.2-0.61.0
Progressive ratio test 1 breakpoint0.20.41.10.60.61.10.40.5-0.9-0.80.1-0.5-0.3-0.0-0.41.0
Progressive ratio test 1 inactive lever presses0.51.32.31.21.11.01.31.5-1.1-1.11.1-1.4-0.91.3-1.10.1
Progressive ratio test 2 active lever presses0.91.32.21.21.21.21.31.5-1.1-1.11.1-1.0-1.01.2-1.30.6
Progressive ratio test 2 breakpoint0.71.01.91.01.00.91.21.4-0.9-0.91.0-0.8-0.81.1-1.10.3
Progressive ratio test 2 inactive lever presses1.03.14.52.01.91.72.02.1-1.7-1.61.9-1.8-1.51.9-1.80.5
Incentive Sensitization - Responses0.41.22.71.00.90.51.31.6-0.7-0.81.3-0.9-0.71.6-1.2-0.6
Incentive Sensitization - Breakpoint0.51.23.01.00.90.51.31.7-0.6-0.81.3-0.9-0.71.7-1.2-0.7
Sum of active levers in priming session hrs 5-60.10.10.20.30.20.3-0.1-0.0-0.2-0.4-0.2-0.4-0.1-0.20.10.5
Progressive ratio0.20.61.6-0.5-0.7-0.8-0.9-0.60.70.3-0.90.30.8-0.60.9-1.3
Food seeking constrained by brief footshock0.20.30.80.60.60.8-0.1-0.5-0.5-0.4-0.1-0.0-0.3-0.6-0.30.9
Seeking ratio, punishment vs. effort0.10.21.30.20.40.60.1-0.4-0.30.00.10.2-0.3-0.4-0.41.2
Retroperitoneal fat weight0.10.51.40.20.40.50.80.6-0.70.21.0-0.4-1.00.7-0.61.2
Reaction time number correct0.20.71.50.70.70.41.01.0-0.7-0.71.1-0.9-1.01.2-0.5-0.1
Reaction time mean minus median0.00.20.5-0.4-0.6-0.6-0.30.20.60.2-0.50.30.50.00.3-0.7
Reaction time mean minus median AUC0.00.10.5-0.1-0.3-0.40.00.40.30.1-0.00.00.10.4-0.3-0.7
Reaction time num false alarms0.50.92.3-1.1-1.2-1.5-0.5-0.31.31.1-0.30.80.90.10.4-1.3
Reaction time num false alarms AUC0.40.92.1-1.1-1.2-1.5-0.6-0.41.21.2-0.40.90.9-0.00.4-1.2
Reaction time trials correct on left0.20.71.50.70.70.41.01.0-0.7-0.71.1-0.9-1.01.2-0.5-0.1
Reaction time trials on left0.30.91.80.80.80.51.21.2-0.8-0.81.2-1.0-1.21.3-0.6-0.0
Reaction time mean0.10.30.50.70.50.20.40.7-0.3-0.70.4-0.6-0.30.6-0.3-0.5
Reaction time mean AUC0.10.20.80.50.3-0.00.20.50.0-0.50.3-0.6-0.10.6-0.1-0.9
Median of all reaction times0.20.40.70.90.70.40.50.6-0.5-0.80.6-0.8-0.40.7-0.4-0.5
Reaction time omissions2.74.36.32.22.11.82.42.5-1.8-1.92.4-1.8-2.22.5-2.20.6
Reaction time false alarm rate1.11.52.3-1.4-1.4-1.5-1.1-1.11.51.5-0.91.31.4-0.80.6-0.9
Reaction time premature initiation rate0.30.40.8-0.8-0.8-0.5-0.8-0.60.30.6-0.90.60.7-0.80.50.1
Reaction time premature initiations0.00.00.1-0.2-0.2-0.1-0.10.0-0.20.1-0.1-0.00.1-0.10.00.3
Std. dev. reaction times0.00.10.40.40.20.20.30.7-0.2-0.40.1-0.2-0.20.4-0.50.0
Reaction time trials completed0.30.91.80.80.80.51.21.2-0.8-0.81.2-1.0-1.21.3-0.6-0.0
Reaction time trials AUC0.31.12.10.90.90.61.31.3-0.9-0.81.3-1.1-1.21.5-0.6-0.0
Run reversals in cocaine runway, females0.10.10.30.30.30.40.20.2-0.5-0.10.2-0.5-0.30.1-0.20.4
Run reversals in cocaine runway, males3.33.66.1-1.9-2.0-1.6-2.1-1.81.91.2-2.52.02.1-2.02.0-1.1
Latency to leave start box in cocaine runway1.72.33.21.61.61.31.81.6-1.2-1.71.8-1.4-1.51.7-1.60.8
Latency to leave start box in cocaine runway, F0.40.51.20.70.60.60.91.0-0.5-1.10.7-0.5-0.50.9-0.80.0
Latency to leave start box in cocaine runway, M2.01.93.41.51.51.01.61.3-1.0-1.11.8-1.6-1.51.6-1.20.4
Std. dev. time between licks in bursts1.12.13.01.61.51.11.61.7-1.0-1.51.7-1.7-1.61.7-1.00.1
Total sessions with >9 infusions0.60.81.31.21.11.01.00.8-0.7-1.11.0-0.9-0.70.8-0.60.1
Short access day 1 total inactive lever presses0.00.10.50.00.10.30.20.1-0.5-0.00.1-0.1-0.10.0-0.30.7
Short access day 10 total inactive lever presses0.10.61.10.70.80.70.80.6-0.9-0.50.8-0.7-0.80.6-1.10.9
Short access day 1 total infusions1.42.74.21.92.02.01.81.5-1.6-1.71.7-1.5-1.51.3-1.21.4
Short access day 10 total infusions0.10.10.30.20.20.4-0.1-0.1-0.2-0.4-0.4-0.30.3-0.40.60.3
Short access total infusions0.50.71.51.01.01.20.80.6-0.9-1.10.6-0.8-0.50.4-0.20.7
Short access day 1 locomotion0.10.20.60.50.50.30.30.1-0.2-0.20.6-0.8-0.60.30.2-0.1
Short access day 10 total locomotion0.00.10.6-0.1-0.2-0.3-0.2-0.20.80.0-0.10.20.4-0.00.5-0.8
Short access total locomotion0.10.10.60.0-0.0-0.2-0.2-0.10.6-0.1-0.1-0.00.3-0.00.5-0.8
One hour access (0.3 mA shock)0.60.72.20.90.91.40.60.6-1.0-0.80.2-0.6-0.50.0-0.51.5
Compulsive drug intake0.10.10.6-0.6-0.5-0.50.0-0.00.30.80.20.40.00.20.0-0.2
One hour access (shock baseline)0.61.63.41.51.51.81.11.1-1.4-1.60.6-1.2-0.90.5-0.81.4
Social response proportion2.32.94.31.61.71.62.12.0-1.2-1.22.0-1.2-2.11.9-1.51.9
Social responses2.73.65.71.71.91.82.42.2-1.1-1.62.3-1.4-2.32.1-1.12.1
Social time0.61.03.90.0-0.0-0.71.11.50.70.61.5-0.5-0.82.0-0.3-1.2
Soleus weight0.41.33.4-0.7-0.6-0.4-1.5-1.80.50.8-1.40.71.3-1.91.20.1
Bone: stiffness1.32.43.9-1.8-1.7-1.7-1.5-1.71.52.0-1.21.81.5-1.31.3-0.5
Tibialis anterior weight7.325.231.4-5.1-5.2-5.2-5.3-5.15.25.0-4.94.75.4-4.45.6-3.9
Time to tail flick, vehicle, before self-admin1.21.42.0-1.4-1.4-1.2-1.4-1.11.11.2-1.41.11.2-1.21.1-0.6
Time to tail flick, vehicle, after self-admin0.40.81.6-1.1-1.1-0.9-1.1-0.80.60.8-1.30.90.9-1.00.3-0.3
Time to tail flick, test, before self-admin0.10.10.2-0.0-0.0-0.20.30.3-0.10.40.4-0.2-0.30.5-0.3-0.1
Time to tail flick, test, after self-admin5.15.47.82.52.52.32.82.7-1.6-2.12.6-2.1-2.52.6-2.01.5
Delta time to tail flick, vehicle, before/after SA0.50.51.40.60.70.60.80.8-0.5-0.40.8-0.5-0.80.8-1.20.5
Delta time to tail flick, test, before/after SA2.53.14.22.12.01.82.01.9-1.3-1.91.9-1.6-1.71.8-1.61.0
Tibia length1.13.110.3-1.9-2.1-2.8-0.60.22.51.7-0.31.11.20.91.2-3.2
Ambulatory time before self-admin0.00.00.20.20.2-0.10.1-0.10.20.00.4-0.5-0.00.2-0.2-0.3
Ambulatory time after self-admin1.01.53.2-1.0-1.0-1.1-1.5-1.81.21.0-1.30.91.3-1.51.4-0.9
Bone: tissue strength0.60.61.30.90.70.60.81.0-0.7-1.10.7-1.0-0.80.9-0.5-0.2
Total heroin consumption0.50.61.5-0.6-0.7-0.5-1.0-0.70.80.2-1.20.60.8-1.01.1-0.3
Bone: trabecular number0.91.64.40.90.90.51.81.8-0.7-0.81.8-0.7-1.32.1-1.30.1
Bone: trabecular spacing2.23.27.6-1.3-1.3-0.8-2.3-2.51.31.3-2.51.41.8-2.82.1-0.2
Bone: trabecular thickness0.60.81.9-1.3-1.2-1.2-0.6-0.51.01.4-0.51.00.8-0.30.8-0.3
Bone: trabecular tissue density2.34.16.6-1.7-1.8-1.6-2.6-2.51.51.7-2.51.52.4-2.51.7-1.5
Water consumed over 24 hours0.61.12.4-1.2-1.2-1.3-0.9-0.71.51.0-0.81.01.0-0.51.2-1.0
Number of responses in last shaping day0.50.61.8-0.5-0.6-0.2-1.0-0.90.50.3-1.30.50.7-1.30.90.0