Fads3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Fads3	0.05	0.03	5.0e-06	0.02	0.03	0.02	0.02	2.8e-03	2.5e-04	4.3e-03	1.8e-03
2	Liver	gene expression	Fads3	0.04	0.03	1.3e-03	0.01	0.02	0.01	0.01	1.7e-02	6.2e-03	7.2e-03	1.1e-02
3	IL	gene expression	Fads3	0.22	0.14	2.9e-04	0.08	0.11	0.03	0.08	5.0e-03	1.6e-03	7.1e-02	6.8e-03
4	NAcc	gene expression	Fads3	0.19	0.08	0.0e+00	0.27	0.27	0.26	0.27	1.5e-40	7.6e-41	5.9e-40	7.0e-41
5	IC	gene expression	Fads3	0.24	0.12	7.3e-09	0.18	0.16	0.16	0.16	5.8e-08	3.3e-07	3.6e-07	2.9e-07
6	pVTA	gene expression	Fads3	0.13	0.08	3.5e-09	0.08	0.11	0.1	0.1	2.9e-07	2.0e-09	2.1e-08	1.1e-08
7	Brain	gene expression	Fads3	0.14	0.07	3.1e-10	0.07	0.08	0.08	0.08	3.4e-07	2.9e-08	5.5e-08	6.1e-08
8	PL	gene expression	Fads3	0.16	0.08	5.6e-17	0.14	0.16	0.16	0.15	2.2e-15	6.8e-17	2.9e-17	3.1e-16
9	BLA	gene expression	Fads3	0.13	0.1	3.0e-05	0.1	0.09	0.12	0.1	6.1e-06	2.3e-05	1.2e-06	9.7e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.3	0.5	1.1	0.2	0.2	-0.5	-0.7	0.3	-0.7	-0.9	1.0	1.1
Area under the delay curve	0.2	0.3	0.7	0.0	0.2	-0.3	-0.5	0.6	-0.7	-0.7	0.9	0.3
BMI with tail	3.4	11.9	20.1	2.0	2.0	-3.0	-3.6	3.1	-3.6	-3.9	4.4	4.5
BMI without tail	0.5	2.9	4.2	1.1	1.4	-1.5	-1.8	1.5	-1.9	-1.8	2.0	1.9
Body weight	4.0	17.5	23.2	3.2	3.3	-4.0	-4.6	4.4	-4.5	-4.6	4.8	3.9
Weight adjusted by age	0.4	1.2	1.6	1.3	1.1	-1.3	-1.1	1.1	-1.0	-0.9	1.0	1.1
Bone surface	1.5	2.9	4.6	1.2	1.1	-1.6	-1.9	1.6	-1.8	-2.1	2.1	1.7
Bone volume	0.5	1.1	2.1	0.5	0.3	-0.8	-1.1	0.6	-1.0	-1.3	1.4	1.4
Breakpoint value in progressive ratio session	1.3	2.4	4.4	2.1	2.0	-1.8	-1.7	1.6	-1.4	-1.2	1.1	-0.1
Number of licking bursts	0.0	0.0	0.0	-0.1	-0.0	0.0	0.0	-0.1	-0.0	-0.1	-0.1	0.1
Context. condit. distance diff. score	0.1	0.1	0.3	-0.3	-0.2	0.2	0.0	-0.0	0.1	0.1	0.3	0.6
Locomotion velocity, session 1	0.1	0.1	0.2	0.2	0.2	-0.3	-0.2	0.2	-0.3	-0.2	0.5	0.1
Locomotion distance, session 1	1.0	1.2	2.1	1.0	1.0	-1.2	-1.1	1.0	-1.2	-1.1	1.5	0.8
Locomotion velocity, session 2	2.9	3.5	4.3	1.8	1.8	-2.0	-1.9	2.1	-2.0	-2.0	1.9	1.3
Locomotion distance, session 2	0.6	0.8	1.1	0.9	1.1	-1.0	-0.8	1.0	-1.0	-0.8	0.9	0.2
Locomotion velocity, session 3	1.1	1.3	5.1	0.1	0.2	-0.6	-0.9	0.7	-1.1	-1.3	1.5	2.3
Locomotion distance, session 3	0.0	0.0	0.1	-0.1	-0.1	0.0	-0.1	-0.0	-0.2	-0.2	0.2	0.3
Stereotopy head waving bouts, day 3	0.4	0.5	2.3	-0.3	-0.1	-0.2	-0.4	0.4	-0.7	-0.7	1.1	1.5
Stereotopy head waving duration, day 3	0.3	0.4	1.1	-0.0	0.2	-0.3	-0.4	0.5	-0.7	-0.6	0.8	1.0
Locomotion velocity, session 7	0.1	0.1	0.3	-0.0	0.0	-0.1	-0.3	0.2	-0.4	-0.4	0.6	0.3
Locomotion distance, session 7	0.1	0.1	0.4	-0.2	0.0	-0.0	-0.2	0.1	-0.3	-0.3	0.6	0.3
Stereotopy head waving bouts, day 7	0.2	0.2	0.4	0.3	0.2	-0.5	-0.5	0.4	-0.5	-0.6	0.6	0.7
Stereotopy head waving duration, day 7	1.4	1.7	2.2	1.3	1.2	-1.4	-1.5	1.3	-1.4	-1.4	1.4	0.8
Locomotion velocity, session 8	0.1	0.1	0.4	0.3	0.5	-0.2	-0.2	0.3	-0.2	0.0	0.1	-0.6
Locomotion distance, session 8	0.1	0.1	0.3	-0.3	-0.2	0.1	-0.0	0.1	-0.1	-0.1	0.6	0.6
Degree of sensitization distance	0.3	0.3	1.1	-0.1	-0.0	-0.3	-0.4	0.4	-0.5	-0.6	1.0	1.0
Degree of sensitization stereotypy	0.8	0.9	1.1	1.0	0.8	-1.0	-1.0	1.0	-0.9	-1.0	0.9	0.8
Conditioned locomotion	0.5	0.6	0.8	0.8	0.9	-0.9	-0.8	0.9	-0.9	-0.8	0.7	-0.1
Cocaine response after cond. corrected	0.1	0.2	0.3	-0.5	-0.4	0.4	0.4	-0.3	0.3	0.5	-0.2	0.5
Cocaine response after cond. not corrected	0.2	0.3	0.4	-0.6	-0.6	0.5	0.6	-0.6	0.5	0.5	-0.2	0.6
Cocaine response before conditioning	0.0	0.0	0.2	0.3	-0.2	-0.2	0.1	-0.4	0.2	-0.1	-0.1	-0.0
Saline control response	2.3	3.1	4.2	2.1	2.0	-2.0	-1.9	1.8	-1.8	-1.7	1.7	-0.2
Bone: connectivity density	1.6	2.5	4.1	1.2	1.2	-1.5	-1.7	1.4	-1.7	-1.8	2.0	1.5
Bone: cortical apparent density	0.2	0.3	0.7	0.9	0.8	-0.6	-0.4	0.3	-0.3	-0.2	-0.1	-0.4
Bone: cortical area	0.4	0.6	0.9	0.7	0.6	-0.8	-0.9	0.6	-0.8	-1.0	0.9	0.4
Bone: cortical porosity	0.2	0.2	0.9	0.5	0.6	-0.2	-0.1	0.4	0.1	0.3	-0.5	-1.0
Bone: cortical porosity	0.3	0.3	0.7	0.7	0.8	-0.4	-0.4	0.6	-0.2	0.0	-0.1	-0.8
Bone: cortical thickness	2.2	3.7	6.5	2.5	2.5	-2.2	-2.1	2.1	-1.8	-1.5	1.1	-0.5
Bone: cortical thickness	0.2	0.2	0.5	0.7	0.7	-0.5	-0.4	0.3	-0.4	-0.2	0.0	-0.4
Bone: cortical tissue density	0.3	0.4	1.1	1.1	1.0	-0.8	-0.6	0.5	-0.5	-0.4	0.1	-0.4
Condit. Reinf. active minus inactive responses	0.8	0.9	1.3	1.1	1.0	-1.2	-0.9	0.7	-0.9	-0.9	0.8	0.9
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.9	1.0	0.9	-0.8	-0.5	0.5	-0.5	-0.3	0.2	0.2
Condit. Reinf. active responses	0.7	0.9	1.9	0.9	0.7	-1.1	-0.9	0.6	-1.0	-1.0	1.1	1.4
Condit. Reinf. inactive responses	0.2	0.3	1.4	-0.4	-0.6	0.1	0.1	-0.3	0.0	-0.3	0.5	1.2
Incentive salience index mean	1.0	1.2	2.0	0.9	0.8	-1.2	-1.1	0.9	-1.1	-1.2	1.3	1.4
Condit. Reinf. lever presses	0.6	0.9	2.2	0.4	0.3	-0.8	-0.9	0.7	-0.9	-1.2	1.3	1.5
Condit. Reinf. active minus inactive responses	0.2	0.3	0.6	-0.3	-0.5	0.4	0.7	-0.8	0.6	0.5	-0.7	-0.1
Condit. Reinf. active-inactive response ratio	0.2	0.4	0.8	-0.7	-0.9	0.5	0.7	-0.7	0.5	0.3	-0.4	0.7
Condit. Reinf. active responses	0.0	0.0	0.1	0.2	0.0	-0.2	0.1	-0.2	0.0	-0.1	-0.1	0.1
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.3	0.3	-0.2	-0.1	-0.1	-0.1	-0.0	-0.0	-0.3
Condit. Reinf. lever presses	0.4	0.6	1.4	0.7	0.4	-0.8	-0.7	0.6	-0.7	-1.0	0.8	1.2
Condit. Reinf. lever reinforcers received	0.0	0.1	0.2	0.5	0.3	-0.4	-0.1	-0.0	-0.1	-0.2	-0.1	0.1
Conditioned reinforcement - actives	0.1	0.4	0.7	-0.3	-0.5	0.4	0.8	-0.9	0.7	0.6	-0.7	0.2
Conditioned reinforcement - inactives	0.1	0.3	1.8	-0.4	-0.7	0.2	0.2	-0.1	0.2	-0.2	0.3	1.4
Conditioned locomotion	1.2	1.7	3.2	-1.7	-1.8	1.4	1.3	-1.5	1.0	0.7	-0.8	1.1
Patch foraging indifference point 0 sec	0.3	0.8	1.4	0.9	0.9	-0.9	-1.2	1.0	-0.9	-0.9	1.0	0.2
Patch foraging indifference point AUC	0.4	1.0	1.8	1.4	1.2	-1.2	-1.0	1.0	-0.9	-0.9	0.5	-0.4
Delay disc. indifference point, 0s delay	0.2	0.3	0.9	-0.7	-0.5	0.2	0.1	-0.0	-0.3	-0.4	0.6	0.9
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	0.1	0.0	-0.2	-0.3	0.3	-0.3	-0.4	0.6	0.4
Delay disc. indifference point, 2s delay	0.3	0.3	0.8	-0.9	-0.9	0.5	0.3	-0.5	0.1	-0.2	0.2	0.8
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.1	0.3	-0.3	-0.4	0.2	-0.5	-0.5	0.5	0.2
Delay disc. indifference point, 4s delay	0.8	0.9	1.7	0.3	0.6	-0.7	-1.0	1.1	-1.2	-1.2	1.3	0.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.6	-0.4	-0.2	0.4	0.1	0.1	0.0	0.1	-0.0	-0.7
Indifference point function ln k	1.0	3.1	5.8	-2.4	-2.2	2.1	1.8	-1.7	1.7	1.5	-1.1	0.7
Indifference point function log k	1.0	3.1	5.8	-2.4	-2.2	2.1	1.8	-1.7	1.7	1.5	-1.1	0.7
Patch foraging total patch changes 0 sec	0.3	0.8	1.3	0.9	1.0	-0.9	-1.1	1.0	-0.9	-0.7	0.9	0.0
Patch foraging total patch changes 12 sec	5.2	6.9	10.2	3.2	3.2	-3.0	-2.9	2.8	-2.6	-2.4	2.1	0.1
Patch foraging total patch changes 18 sec	0.2	0.5	1.1	1.0	1.0	-0.9	-0.7	0.7	-0.7	-0.5	0.2	-0.5
Patch foraging total patch changes 24 sec	2.2	7.4	9.5	2.8	2.8	-2.9	-3.1	2.9	-2.9	-2.8	2.8	0.7
Patch foraging total patch changes 6 sec	0.9	1.5	2.1	1.2	1.2	-1.2	-1.5	1.3	-1.3	-1.3	1.3	0.4
Patch foraging time to switch 0 sec	0.2	0.6	1.5	0.4	0.3	-0.7	-0.6	0.4	-0.8	-1.0	1.0	1.2
Patch foraging water rate 0 sec	0.3	1.0	1.6	-0.8	-0.8	1.0	1.0	-0.9	1.1	1.2	-1.2	-1.0
Patch foraging water rate 12 sec	0.5	2.0	2.7	-1.6	-1.4	1.6	1.5	-1.2	1.5	1.6	-1.3	-0.5
Patch foraging water rate 18 sec	0.2	0.3	0.8	-0.9	-0.7	0.8	0.4	-0.5	0.5	0.6	-0.0	-0.3
Patch foraging water rate 24 sec	1.1	1.5	2.1	-1.3	-1.2	1.4	1.3	-1.1	1.4	1.4	-1.2	-0.8
Patch foraging water rate 6 sec	0.8	1.2	1.8	-1.2	-1.0	1.3	1.1	-0.8	1.2	1.3	-1.1	-0.8
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.6	-0.0	-0.0	-0.2	-0.2	0.2	-0.4	-0.5	0.4	0.8
Distance traveled before self-admin	0.7	1.5	2.3	1.2	1.0	-1.4	-1.2	1.0	-1.3	-1.5	1.3	0.9
Distance traveled after self-admin	0.1	0.3	0.6	0.8	0.7	-0.7	-0.3	0.5	-0.4	-0.4	0.2	-0.2
Extensor digitorum longus weight	5.9	23.4	27.0	4.8	4.7	-5.1	-5.2	5.2	-5.2	-5.0	4.9	3.0
Bone: elastic displacement	0.4	0.5	1.7	-0.1	0.0	0.5	0.5	-0.4	0.6	0.9	-1.0	-1.3
Bone: elastic work	0.9	1.2	2.3	1.3	1.5	-1.2	-1.2	1.1	-1.0	-0.7	0.7	-0.4
Bone: endosteal estimation	0.9	2.3	5.1	-2.2	-2.2	1.6	1.2	-1.6	1.0	0.5	0.1	1.7
Bone: endosteal perimeter	1.5	3.6	8.3	-2.7	-2.9	2.1	1.7	-2.1	1.5	0.8	-0.3	1.4
Epididymis fat weight	0.5	2.6	5.9	-2.3	-2.4	1.7	1.3	-1.5	1.2	0.7	-0.3	1.8
Delta time in closed arm before/after self-admin	2.9	2.7	4.8	1.6	1.9	-1.6	-1.8	2.2	-1.7	-1.3	1.7	0.6
Delta time in open arm before/after self-admin	0.8	1.0	1.7	1.3	1.0	-1.2	-1.0	0.9	-0.9	-1.0	0.9	0.3
Diff in mean of infusions in LGA sessions	1.6	2.9	4.2	2.0	2.1	-1.9	-1.9	2.0	-1.7	-1.5	1.4	0.5
Delay discount exponential model param	0.2	0.3	0.7	-0.0	-0.2	0.3	0.6	-0.6	0.7	0.8	-0.9	-0.3
Extinction: sum of active levers before priming	2.3	3.6	4.3	1.9	1.8	-2.0	-2.1	2.1	-1.9	-1.9	2.0	1.0
Active lever presses in extinction session 6	1.6	1.6	2.7	1.6	1.3	-1.5	-1.3	1.2	-1.1	-1.2	1.2	0.2
Bone: final force	1.0	1.7	2.6	1.2	1.0	-1.3	-1.4	1.1	-1.4	-1.5	1.6	1.0
Bone: final moment	1.1	1.7	2.6	1.2	1.1	-1.4	-1.4	1.1	-1.4	-1.5	1.6	0.9
Food consumed during 24 hour testing period	0.2	0.4	0.7	-0.5	-0.6	0.6	0.8	-0.5	0.8	0.8	-0.8	-0.0
Glucose	1.8	2.8	5.9	-2.4	-2.3	1.9	1.8	-1.8	1.4	1.2	-0.7	0.5
Heart weight	0.4	0.7	3.2	-1.0	-0.7	0.4	-0.1	-0.2	-0.3	-0.5	0.9	1.8
Delay discount hyperbolic model param	0.2	0.2	0.6	0.1	-0.0	0.2	0.4	-0.4	0.6	0.7	-0.8	-0.4
Intermittent access intake day 1-15 change	0.4	2.4	3.4	-1.4	-1.7	1.5	1.8	-1.8	1.7	1.4	-1.7	-0.9
Intermittent access intake escalation	0.5	2.9	4.1	-1.6	-1.8	1.7	2.0	-1.8	1.9	1.6	-1.9	-0.8
Intermittent access intake escalation 2	0.5	0.8	1.3	-0.8	-1.0	0.8	1.1	-1.1	1.0	0.8	-1.0	-0.5
Intermitt. access day 1 inactive lever presses	0.1	0.8	1.1	-0.9	-1.0	0.9	1.1	-0.8	1.0	0.9	-1.0	0.7
Intermitt. access day 15 inactive lever presses	0.3	1.6	7.0	0.3	-0.0	-0.9	-0.8	0.7	-1.1	-1.6	1.3	2.6
Intermitt. access escalation Index	0.2	0.5	0.9	-0.9	-0.8	0.9	0.7	-0.6	0.7	0.7	-0.7	-0.2
Intermittent access day 1 total infusions	0.4	1.1	4.6	-1.2	-1.3	0.3	-0.1	0.0	-0.3	-0.9	1.0	2.1
Intermittent access day 15 total infusions	1.4	3.4	7.6	-2.5	-2.8	2.0	1.9	-1.9	1.6	1.0	-1.2	0.6
Intermittent access terminal intake (last 3 days)	0.6	1.1	3.5	-1.6	-1.9	0.9	0.8	-0.9	0.6	-0.0	0.0	1.2
Intermittent access total infusions	0.9	1.0	3.1	-1.6	-1.8	0.9	0.7	-0.7	0.4	-0.2	0.2	1.3
Intermittent access day 1 locomotion	0.4	0.8	4.1	-0.5	-0.6	-0.1	-0.5	0.3	-0.5	-0.9	1.0	2.0
Intermittent access day 15 total locomotion	0.2	0.6	2.8	-0.7	-1.0	0.1	0.0	-0.1	-0.1	-0.7	0.6	1.7
Intermittent access total locomotion	1.3	1.6	7.9	-1.2	-1.5	0.2	0.0	-0.2	-0.3	-1.0	1.0	2.8
Intermittent access standard deviation	0.1	0.7	1.0	-0.7	-0.9	0.8	0.9	-0.7	1.0	0.9	-0.9	-0.5
Left kidney weight	0.1	0.9	2.9	-1.3	-1.3	0.7	0.2	-0.5	0.2	-0.3	0.5	1.7
Right kidney weight	0.1	0.4	1.0	-1.0	-1.0	0.5	0.1	-0.2	0.1	-0.2	0.3	1.0
Cocaine induced anxiety	0.0	0.1	0.4	0.3	0.2	-0.2	0.0	-0.0	0.1	0.1	-0.2	-0.7
Post-drug Anxiety	0.2	0.2	0.3	0.5	0.4	-0.6	-0.3	0.2	-0.5	-0.6	0.5	0.2
Baseline Anxiety	0.3	0.5	0.8	0.4	0.5	-0.6	-0.7	0.5	-0.9	-0.9	0.9	0.8
Tail length	0.2	1.2	2.5	1.4	1.6	-1.1	-1.1	1.3	-1.0	-0.6	0.4	-0.8
Length with tail	1.2	5.2	7.4	2.4	2.4	-2.4	-2.5	2.7	-2.4	-2.3	2.1	0.8
Length without tail	1.7	9.0	12.8	2.8	2.9	-3.1	-3.4	3.6	-3.2	-3.1	3.0	1.7
Times rat made contact with spout	0.2	0.2	0.6	0.7	0.8	-0.5	-0.3	0.4	-0.3	-0.0	-0.1	-0.5
Lifetime Intake	0.5	0.7	1.9	-1.3	-1.4	0.7	0.4	-0.4	0.2	-0.2	0.2	1.2
Liver weight, left	0.9	1.5	1.8	-1.2	-1.1	1.3	1.3	-1.2	1.3	1.3	-1.2	-0.9
Liver weight, right	1.0	1.8	3.4	-1.8	-1.7	1.6	1.4	-1.3	1.3	1.2	-0.8	0.1
Locomotor activity	0.4	0.6	1.1	-0.7	-0.4	0.9	0.6	-0.7	0.7	1.0	-0.7	-1.1
Locomotor testing distance	0.2	0.6	0.9	-0.9	-0.7	0.9	0.7	-0.9	0.7	0.9	-0.7	-0.5
Locomotor testing rearing	0.3	1.0	1.6	-1.0	-0.9	1.1	1.0	-1.1	1.1	1.3	-0.9	-0.5
Locomotion in novel chamber	1.3	1.7	3.2	-1.7	-1.8	1.5	1.4	-1.3	1.3	1.0	-1.0	-0.3
Locomotion in novel chamber post-restriction	0.7	2.0	2.7	-1.3	-1.3	1.5	1.5	-1.4	1.6	1.6	-1.6	-0.9
Fecal boli incidents, locomotor time 1	0.2	0.5	0.9	-0.5	-0.8	0.6	0.7	-0.9	0.8	0.7	-0.8	-0.5
Change in fecal boli incidents, locomotor task	0.6	0.7	1.6	-1.3	-1.0	1.0	0.7	-0.8	0.5	0.5	-0.5	0.7
Time >=10cm from walls, locomotor time 1	1.6	2.0	3.9	-1.7	-2.0	1.5	1.4	-1.5	1.5	1.1	-1.0	0.3
Bouts of movement, locomotor time 1	0.7	0.9	3.9	1.3	1.1	-0.6	-0.3	0.7	0.1	0.4	-0.7	-2.0
Total resting periods, locomotor time 1	0.6	0.7	3.2	1.1	0.9	-0.5	-0.3	0.5	0.1	0.3	-0.6	-1.8
Rest time, locomotor task time 1	1.4	2.2	3.0	-1.3	-1.4	1.5	1.5	-1.5	1.6	1.5	-1.7	-1.2
Distance moved, locomotor task time 1	0.2	0.5	1.3	0.4	0.4	-0.6	-0.5	0.6	-0.7	-0.8	0.9	1.2
Vertical activity count, locomotor time 1	0.0	0.3	0.6	-0.7	-0.7	0.7	0.6	-0.4	0.6	0.6	-0.3	0.1
Time >=10cm from walls, locomotor time 2	0.2	0.5	1.2	-0.4	-0.6	0.5	0.8	-1.1	0.8	0.7	-0.8	-0.3
Bouts of movement, locomotor time 2	0.4	1.3	2.4	1.6	1.4	-1.4	-1.2	1.3	-0.9	-0.8	0.8	0.7
Total resting periods, locomotor time 2	0.2	0.8	1.4	1.2	1.0	-1.0	-0.9	1.1	-0.6	-0.5	0.5	0.7
Rest time, locomotor task time 2	1.4	2.4	2.9	-1.6	-1.6	1.7	1.6	-1.2	1.7	1.7	-1.7	-0.9
Distance moved, locomotor task time 2	0.2	0.2	0.6	0.8	0.7	-0.6	-0.4	0.4	-0.4	-0.3	0.2	-0.2
Vertical activity count, locomotor time 2	0.1	0.2	1.1	0.1	0.3	0.2	0.1	-0.0	0.3	0.5	-0.5	-1.1
Light reinforcement 1	0.1	0.3	0.8	-0.4	-0.5	0.4	0.6	-0.9	0.5	0.4	-0.6	-0.1
Light reinforcement 2	0.3	0.7	1.7	-1.0	-1.3	0.8	0.7	-1.0	0.6	0.2	-0.1	1.0
Bone: marrow area	1.0	2.6	5.6	-2.3	-2.4	1.7	1.4	-1.7	1.1	0.6	-0.0	1.6
Bone: maximum diameter	0.1	0.2	0.8	-0.1	-0.3	-0.2	-0.3	-0.0	-0.3	-0.6	0.7	0.9
Bone: maximum force	1.7	3.3	5.9	1.3	1.1	-1.7	-1.9	1.5	-1.9	-2.2	2.4	1.9
Bone: maximum moment	1.7	3.3	5.6	1.3	1.2	-1.7	-1.9	1.5	-1.9	-2.2	2.4	1.8
Mean time between licks in bursts	0.1	0.6	1.5	0.7	0.9	-0.7	-0.8	1.2	-0.8	-0.5	0.6	0.3
Mean num. licks in bursts	0.0	0.1	0.4	0.3	0.3	-0.0	0.1	0.1	0.2	0.5	-0.4	-0.6
Cd content in liver	0.7	0.8	1.0	-0.9	-1.0	0.9	1.0	-0.9	0.9	0.8	-0.8	-0.5
Co content in liver	0.9	1.0	2.2	-0.5	-0.4	0.9	0.9	-0.7	1.0	1.2	-1.3	-1.5
Cu content in liver	0.0	0.0	0.1	0.1	0.2	0.0	0.1	0.2	0.0	0.1	-0.2	-0.0
Fe content in liver	0.0	0.0	0.0	-0.1	-0.0	0.0	0.0	0.1	-0.1	-0.0	0.1	0.1
K content in liver	0.4	0.3	0.8	0.3	0.2	-0.5	-0.5	0.6	-0.6	-0.8	0.9	0.5
Mg content in liver	0.1	0.1	0.5	-0.2	-0.1	-0.1	-0.3	0.4	-0.3	-0.4	0.7	0.3
Mn content in liver	2.4	2.7	3.3	1.7	1.6	-1.8	-1.7	1.8	-1.7	-1.8	1.6	0.9
Na content in liver	0.1	0.1	0.3	0.3	0.1	-0.4	-0.4	0.2	-0.3	-0.4	0.5	0.1
Rb content in liver	2.0	2.3	3.0	-1.7	-1.6	1.7	1.6	-1.5	1.5	1.6	-1.3	-1.0
Se content in liver	0.1	0.1	0.7	0.2	0.1	-0.3	-0.2	0.3	-0.2	-0.4	0.3	0.8
Sr content in liver	4.5	3.9	5.2	2.3	2.3	-2.2	-2.1	2.2	-2.0	-1.8	1.6	0.9
Zn content in liver	3.0	3.5	4.9	1.9	2.0	-2.0	-2.0	2.2	-2.0	-1.8	1.8	0.4
Bone: minimum diameter	0.7	1.3	3.4	-1.7	-1.8	1.2	0.9	-1.2	0.7	0.2	0.2	1.3
Time in familiar zone, hab. session 1	0.0	0.0	0.2	0.0	-0.1	-0.1	-0.1	-0.0	-0.0	-0.1	0.4	0.4
Time in novel zone, hab. session 1	1.2	1.4	1.6	-1.1	-1.1	1.2	1.3	-1.2	1.2	1.2	-1.3	-0.9
Total zone transitions, hab. session 1	0.3	0.4	0.7	0.8	0.9	-0.7	-0.7	0.6	-0.6	-0.4	0.5	-0.6
Total locomotion distance, hab. session 1	0.0	0.1	0.2	-0.2	-0.2	-0.0	-0.1	-0.0	-0.1	-0.2	0.5	0.4
Locomotion velocity, hab. session 1	0.3	0.4	0.7	0.5	0.5	-0.7	-0.7	0.6	-0.7	-0.7	0.8	0.3
Time in familiar zone, hab. session 2	0.9	1.0	1.4	-0.7	-0.7	0.9	1.0	-0.9	1.1	1.1	-1.2	-1.2
Time in novel zone, hab. session 2	1.0	1.0	1.7	0.7	0.8	-0.9	-1.1	0.9	-1.1	-1.1	1.3	1.1
Total zone transitions, hab. session 2	1.0	1.3	2.2	1.1	1.1	-1.2	-1.3	1.0	-1.2	-1.2	1.5	0.3
Total locomotion distance, hab. session 2	0.2	0.2	0.8	0.2	0.2	-0.4	-0.5	0.3	-0.5	-0.5	0.9	0.5
Locomotion velocity, hab. session 2	0.1	0.2	0.7	0.0	0.0	-0.3	-0.3	0.2	-0.4	-0.5	0.8	0.6
Novel to familiar place preference ratio	2.0	2.6	3.2	1.4	1.6	-1.6	-1.7	1.8	-1.8	-1.7	1.7	0.9
Novelty place preference	1.3	1.6	2.0	1.1	1.2	-1.2	-1.4	1.4	-1.4	-1.4	1.4	0.8
Time in novel zone, NPP test	1.5	1.8	2.3	1.2	1.3	-1.3	-1.5	1.5	-1.5	-1.4	1.5	1.0
Total zone transitions, NPP test	1.1	1.7	2.5	1.5	1.6	-1.5	-1.4	1.2	-1.3	-1.1	1.2	-0.3
Total locomotion distance, NPP test	0.2	0.3	0.5	0.5	0.6	-0.5	-0.6	0.5	-0.6	-0.5	0.7	-0.3
Locomotion velocity, NPP test	0.2	0.2	0.6	0.4	0.5	-0.4	-0.4	0.5	-0.4	-0.3	0.5	-0.7
Intraocular pressure	0.2	0.3	0.7	-0.1	-0.1	0.3	0.6	-0.3	0.6	0.7	-0.8	-0.5
Delta distance traveled before/after self-admin	0.3	0.4	0.8	-0.3	-0.1	0.6	0.6	-0.2	0.6	0.9	-0.7	-0.9
Delta ambulatory time before/after self-admin	0.3	0.6	1.2	-0.5	-0.2	0.7	0.8	-0.5	0.8	1.1	-1.0	-0.8
Parametrial fat weight	1.3	3.2	7.5	-2.7	-2.7	2.0	1.4	-1.9	1.3	0.6	-0.4	1.4
Pavlov. Cond. lever latency	0.7	0.9	1.5	-0.7	-0.6	0.9	1.0	-0.9	0.9	1.1	-1.2	-1.1
Pavlov. Cond. magazine entry latency	0.6	0.8	1.6	0.7	0.4	-0.9	-0.8	0.7	-0.8	-1.1	1.1	1.3
Pavlov. Cond. change in total contacts	0.2	0.2	0.6	0.4	0.1	-0.5	-0.3	0.4	-0.3	-0.5	0.5	0.8
Pavlov. Cond. index score	0.3	0.4	0.5	0.6	0.4	-0.7	-0.6	0.7	-0.6	-0.7	0.7	0.7
Pavlov. Cond. latency score	0.3	0.4	0.7	0.5	0.3	-0.6	-0.6	0.6	-0.5	-0.7	0.8	0.8
Pavlov. Cond. lever contacts	0.3	0.4	0.8	0.3	0.2	-0.5	-0.6	0.5	-0.6	-0.7	0.9	0.8
Pavlov. Cond. magazine entry number	0.4	0.5	0.8	-0.9	-0.6	0.8	0.6	-0.8	0.6	0.7	-0.5	-0.5
Pavlov. Cond. intertrial magazine entries	0.2	0.3	1.7	0.4	0.4	-0.2	-0.1	-0.2	0.0	0.1	-0.4	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.6	0.7	0.5	-0.8	-0.7	0.7	-0.6	-0.8	0.7	0.7
Pavlov. Cond. response bias	0.5	0.6	0.8	0.8	0.6	-0.9	-0.8	0.8	-0.7	-0.9	0.8	0.8
Pavlov. Cond. lever latency	0.4	0.5	1.5	-0.5	-0.2	0.7	0.5	-0.6	0.6	0.8	-0.7	-1.2
Pavlov. Cond. magazine entry latency	3.4	4.9	6.7	2.5	2.1	-2.6	-2.2	2.3	-2.1	-2.2	1.9	1.8
Pavlov. Cond. change in total contacts	0.4	0.9	1.7	1.0	0.5	-1.1	-0.8	0.8	-0.7	-1.1	0.8	1.3
Pavlov. Cond. index score	1.6	2.5	3.9	1.7	1.2	-1.8	-1.4	1.4	-1.4	-1.7	1.5	2.0
Pavlov. Cond. latency score	1.5	2.4	3.8	1.6	1.1	-1.8	-1.4	1.4	-1.4	-1.7	1.5	1.9
Pavlov. Cond. lever contacts	0.2	0.4	1.4	0.5	0.2	-0.6	-0.4	0.5	-0.4	-0.6	0.4	1.2
Pavlov. Cond. magazine entry number	5.8	7.5	10.2	-3.1	-2.7	3.2	2.7	-2.7	2.7	2.8	-2.4	-2.2
Pavlov. Cond. intertrial magazine entries	1.0	2.1	3.4	-1.4	-1.3	1.5	1.5	-1.8	1.4	1.4	-1.5	-1.2
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.8	4.0	1.8	1.3	-1.9	-1.5	1.5	-1.5	-1.8	1.5	2.0
Pavlov. Cond. response bias	1.4	2.0	3.2	1.4	1.0	-1.6	-1.3	1.5	-1.3	-1.5	1.3	1.8
Time in closed arm before self-admin	0.2	0.3	0.7	-0.6	-0.8	0.4	0.5	-0.7	0.4	0.1	-0.2	0.3
Time in closed arm after self-admin	0.3	0.4	0.6	-0.8	-0.7	0.7	0.7	-0.6	0.5	0.6	-0.4	0.1
Time in open arm before self-admin	0.4	0.4	1.5	-0.6	-0.1	0.7	0.5	-0.2	0.4	0.8	-0.7	-1.2
Time in open arm after self-admin	0.5	0.5	1.0	0.9	1.0	-0.7	-0.7	0.8	-0.5	-0.3	0.2	-0.9
Bone: periosteal estimation	0.2	0.5	1.9	-0.9	-1.0	0.4	0.1	-0.6	0.1	-0.4	0.7	1.4
Bone: periosteal perimeter	0.1	0.3	0.7	-0.6	-0.8	0.3	0.1	-0.5	0.2	-0.2	0.4	0.8
Bone: post-yield work	0.5	0.9	3.1	-1.2	-1.4	0.6	0.2	-0.6	0.1	-0.6	0.9	1.8
Progressive ratio test 1 active lever presses	0.1	0.1	0.4	-0.5	-0.6	0.3	0.3	-0.2	0.2	-0.0	-0.1	0.3
Progressive ratio test 1 breakpoint	0.1	0.1	0.4	-0.5	-0.6	0.3	0.3	-0.2	0.2	0.0	-0.1	0.3
Progressive ratio test 1 inactive lever presses	0.7	1.7	2.9	0.9	0.7	-1.2	-1.3	1.5	-1.3	-1.5	1.4	1.7
Progressive ratio test 2 active lever presses	0.5	0.7	2.0	-1.2	-1.4	0.8	0.8	-0.8	0.6	0.2	-0.2	0.9
Progressive ratio test 2 breakpoint	0.6	0.7	2.0	-1.2	-1.4	0.8	0.8	-0.7	0.5	0.1	-0.2	1.0
Progressive ratio test 2 inactive lever presses	0.2	0.7	2.8	-1.0	-1.3	0.6	0.5	-0.6	0.3	-0.1	0.1	1.7
Incentive Sensitization - Responses	0.3	0.8	2.6	0.2	0.0	-0.6	-0.6	0.6	-0.8	-1.1	1.2	1.6
Incentive Sensitization - Breakpoint	0.3	0.7	2.7	0.0	-0.2	-0.5	-0.5	0.5	-0.7	-1.1	1.1	1.7
Sum of active levers in priming session hrs 5-6	0.3	0.3	1.1	1.0	0.7	-0.7	-0.4	0.5	-0.2	-0.2	-0.1	-0.0
Progressive ratio	0.0	0.1	0.4	-0.5	-0.6	0.1	-0.0	0.2	-0.0	-0.3	0.4	0.3
Food seeking constrained by brief footshock	0.1	0.1	0.4	-0.2	-0.2	0.2	0.2	-0.6	0.1	0.1	0.0	0.4
Seeking ratio, punishment vs. effort	0.0	0.1	0.3	0.2	0.5	-0.2	-0.1	-0.3	-0.3	0.0	0.1	0.5
Retroperitoneal fat weight	2.4	10.5	20.1	-4.5	-4.3	3.9	3.2	-3.2	3.1	2.5	-2.0	0.5
Reaction time number correct	0.1	0.3	0.4	0.6	0.7	-0.5	-0.6	0.6	-0.4	-0.3	0.4	-0.2
Reaction time mean minus median	0.1	0.3	1.0	1.0	0.8	-0.7	-0.5	0.6	-0.3	-0.3	0.1	0.0
Reaction time mean minus median AUC	0.0	0.2	0.6	0.8	0.7	-0.4	-0.1	0.1	0.2	0.3	-0.5	-0.7
Reaction time num false alarms	0.2	0.3	1.5	-0.2	0.1	0.3	0.3	-0.0	0.2	0.5	-0.5	-1.2
Reaction time num false alarms AUC	0.1	0.3	1.5	0.4	0.8	-0.2	-0.3	0.5	-0.3	0.1	-0.2	-1.2
Reaction time trials correct on left	0.1	0.3	0.4	0.6	0.7	-0.5	-0.6	0.6	-0.4	-0.3	0.4	-0.2
Reaction time trials on left	0.1	0.3	0.5	0.7	0.7	-0.6	-0.6	0.7	-0.4	-0.3	0.4	-0.3
Reaction time mean	0.0	0.1	0.3	0.2	-0.1	0.0	0.3	-0.1	0.5	0.4	-0.5	-0.0
Reaction time mean AUC	0.1	0.2	0.5	-0.1	-0.4	0.3	0.6	-0.4	0.7	0.6	-0.7	0.1
Median of all reaction times	0.0	0.0	0.1	0.1	-0.2	0.0	0.2	-0.1	0.4	0.2	-0.3	0.3
Reaction time omissions	0.2	0.3	0.8	0.9	0.8	-0.6	-0.5	0.7	-0.3	-0.2	0.0	-0.3
Reaction time false alarm rate	0.1	0.1	0.6	-0.1	0.1	0.2	0.1	0.0	0.0	0.2	-0.3	-0.8
Reaction time premature initiation rate	3.7	5.7	7.8	1.9	1.9	-2.3	-2.5	2.3	-2.7	-2.8	2.7	2.1
Reaction time premature initiations	2.1	6.2	7.5	2.4	2.4	-2.6	-2.7	2.6	-2.7	-2.7	2.6	1.5
Std. dev. reaction times	0.1	0.2	0.7	0.3	0.2	0.1	0.3	-0.1	0.6	0.7	-0.8	-0.7
Reaction time trials completed	0.1	0.3	0.5	0.7	0.7	-0.6	-0.6	0.7	-0.4	-0.3	0.4	-0.3
Reaction time trials AUC	0.1	0.2	0.3	0.6	0.6	-0.5	-0.6	0.6	-0.4	-0.2	0.4	-0.2
Run reversals in cocaine runway, females	0.7	0.8	1.7	0.2	0.3	-0.6	-1.0	0.7	-1.0	-1.1	1.3	1.2
Run reversals in cocaine runway, males	0.6	0.6	1.5	-0.7	-0.6	0.8	0.6	-0.6	0.7	0.8	-0.8	-1.2
Latency to leave start box in cocaine runway	0.4	0.5	1.4	-1.2	-1.2	0.7	0.4	-0.6	0.3	-0.0	0.1	0.9
Latency to leave start box in cocaine runway, F	0.1	0.2	0.6	-0.2	-0.2	-0.1	-0.4	0.1	-0.4	-0.5	0.5	0.8
Latency to leave start box in cocaine runway, M	2.0	1.9	3.1	-1.8	-1.7	1.6	1.4	-1.5	1.3	1.1	-0.9	-0.0
Std. dev. time between licks in bursts	0.0	0.1	0.2	-0.4	-0.3	0.4	0.2	0.2	0.2	0.3	-0.1	0.4
Total sessions with >9 infusions	0.3	0.3	0.8	-0.7	-0.8	0.6	0.5	-0.3	0.5	0.4	-0.3	0.9
Short access day 1 total inactive lever presses	0.0	0.1	0.4	-0.3	-0.2	0.1	-0.2	0.2	-0.2	-0.3	0.4	0.6
Short access day 10 total inactive lever presses	0.1	0.4	1.0	-0.5	-0.4	0.7	0.7	-0.3	0.8	1.0	-0.8	-0.3
Short access day 1 total infusions	0.4	0.7	1.4	-1.2	-1.2	1.0	0.8	-0.7	0.8	0.7	-0.6	0.3
Short access day 10 total infusions	0.3	0.5	1.5	-0.9	-1.0	0.2	-0.0	0.0	-0.2	-0.6	0.7	1.2
Short access total infusions	0.3	0.4	1.2	-0.9	-0.9	0.4	0.2	-0.0	0.0	-0.2	0.3	1.1
Short access day 1 locomotion	0.1	0.1	0.5	-0.4	-0.4	0.3	0.2	-0.1	0.3	0.2	-0.1	0.7
Short access day 10 total locomotion	0.2	0.8	5.4	-0.4	-0.5	-0.2	-0.3	0.2	-0.5	-0.8	0.9	2.3
Short access total locomotion	0.4	0.6	3.8	-0.5	-0.6	0.0	-0.1	0.1	-0.2	-0.5	0.5	2.0
One hour access (0.3 mA shock)	0.8	1.0	2.6	-1.4	-1.6	1.0	0.9	-0.9	0.7	0.2	-0.3	1.0
Compulsive drug intake	0.5	0.7	2.1	1.2	1.4	-0.9	-0.7	0.9	-0.6	-0.2	0.2	-0.1
One hour access (shock baseline)	1.2	3.1	7.0	-2.4	-2.6	1.9	1.8	-1.9	1.6	1.0	-1.1	0.1
Social response proportion	0.0	0.0	0.2	-0.0	0.0	0.0	-0.0	0.1	-0.1	-0.2	0.1	-0.5
Social responses	0.2	0.3	1.9	0.3	0.4	-0.0	0.1	0.2	0.1	0.3	-0.5	-1.4
Social time	0.2	0.4	2.2	0.5	0.6	-0.1	0.1	0.2	0.2	0.5	-0.5	-1.5
Soleus weight	2.8	8.2	10.2	-2.9	-2.9	3.1	3.1	-3.2	3.0	2.9	-2.7	-1.5
Bone: stiffness	0.2	0.3	0.6	0.4	0.2	-0.5	-0.6	0.4	-0.5	-0.8	0.8	0.8
Tibialis anterior weight	8.3	28.5	35.0	5.9	5.9	-5.9	-5.8	5.9	-5.6	-5.2	4.8	1.7
Time to tail flick, vehicle, before self-admin	0.5	0.6	2.6	0.0	0.0	-0.4	-0.5	0.5	-0.6	-0.8	0.9	1.6
Time to tail flick, vehicle, after self-admin	0.4	0.9	1.6	0.5	0.6	-0.8	-0.9	1.0	-1.0	-1.0	1.1	1.2
Time to tail flick, test, before self-admin	0.5	0.6	1.5	-0.0	0.2	-0.4	-0.8	0.6	-0.9	-1.0	1.2	0.7
Time to tail flick, test, after self-admin	0.1	0.1	0.3	0.1	-0.1	0.1	0.3	-0.4	0.2	0.2	-0.4	-0.6
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.5	0.7	0.7	-0.6	-0.6	0.6	-0.6	-0.4	0.5	-0.1
Delta time to tail flick, test, before/after SA	0.4	0.5	1.7	0.5	0.2	0.0	0.6	-0.4	0.7	0.8	-1.2	-1.3
Tibia length	1.0	2.8	3.8	1.7	1.4	-1.8	-1.8	1.7	-1.7	-1.9	1.7	1.1
Ambulatory time before self-admin	0.3	1.0	1.6	1.1	0.7	-1.2	-1.0	0.7	-1.0	-1.3	1.1	0.6
Ambulatory time after self-admin	0.0	0.1	0.2	0.2	0.0	-0.3	-0.0	-0.0	-0.2	-0.4	0.2	0.5
Bone: tissue strength	0.7	0.7	0.9	-0.9	-0.8	0.9	0.9	-1.0	0.9	0.9	-0.8	-0.3
Total heroin consumption	4.8	5.7	10.0	3.2	3.1	-2.7	-2.5	2.6	-2.2	-1.8	1.7	-0.2
Bone: trabecular number	0.8	1.6	2.8	0.8	0.7	-1.1	-1.3	0.9	-1.3	-1.5	1.7	1.6
Bone: trabecular spacing	0.7	1.0	2.3	-0.4	-0.3	0.7	0.9	-0.9	1.0	1.3	-1.3	-1.5
Bone: trabecular thickness	0.3	0.4	0.8	-0.7	-0.8	0.7	0.5	-0.9	0.6	0.4	-0.4	0.2
Bone: trabecular tissue density	3.7	6.4	8.0	-2.4	-2.3	2.7	2.8	-2.7	2.7	2.7	-2.8	-1.5
Water consumed over 24 hours	0.2	0.4	0.8	0.9	0.9	-0.7	-0.6	0.7	-0.6	-0.5	0.3	0.3
Number of responses in last shaping day	0.6	0.8	1.6	1.0	1.2	-0.9	-0.9	1.2	-0.8	-0.6	0.7	0.1