Stxbp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	gene expression	Stxbp2	0.45	0.16	1.8e-03	0.12	0.09	0.09	0.14	1.2e-03	4.0e-03	4.4e-03	3.3e-04
2	NAcc	isoform ratio	NM_031126.1	0.02	0.01	7.3e-03	0.02	0.01	0.01	0.01	6.5e-04	3.4e-02	7.4e-03	6.6e-03
3	Adipose	gene expression	Stxbp2	0.08	0.05	6.8e-05	0.03	0.02	0.04	0.04	5.5e-04	1.3e-03	5.7e-05	9.0e-06
4	NAcc	gene expression	Stxbp2	0.12	0.06	3.0e-08	0.05	0.05	0.04	0.06	1.5e-08	1.1e-08	3.6e-06	1.4e-09
5	Liver	alternative polyA	XM_006248783.5	0.06	0.03	2.7e-04	0.02	0.03	0.02	0.03	1.6e-03	2.1e-04	2.2e-03	2.1e-04
6	BLA	gene expression	Stxbp2	0.15	0.08	3.1e-04	0.09	0.05	0.04	0.07	2.8e-05	1.1e-03	4.5e-03	1.6e-04
7	PL	gene expression	Stxbp2	0.07	0.04	2.6e-04	0.04	0.03	0.03	0.03	4.6e-05	2.3e-04	2.1e-04	8.4e-04
8	Liver	alternative polyA	NM_031126.1	0.06	0.03	5.4e-04	0.02	0.03	0.02	0.03	2.3e-03	4.0e-04	2.3e-03	4.6e-04
9	Liver	alternative polyA	NM_031126.1	0.06	0.03	4.6e-04	0.02	0.03	0.02	0.03	2.4e-03	3.4e-04	1.8e-03	4.0e-04
10	Liver	alternative polyA	XM_006248783.5	0.06	0.03	3.0e-04	0.02	0.03	0.02	0.03	1.9e-03	2.1e-04	2.2e-03	2.2e-04
11	LHb	alternative TSS	XM_063271697.1	0.21	0.11	9.1e-04	0.13	0.09	0.08	0.09	5.0e-04	4.5e-03	5.1e-03	4.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	2.0	3.5	9.6	-2.8	-2.7	-3.1	-2.1	1.1	-1.1	-1.1	-0.8	-0.7	0.7	2.0
Area under the delay curve	1.7	2.0	10.3	1.2	0.8	3.2	0.4	0.8	-0.9	-0.7	-0.9	-0.9	1.0	-2.2
BMI with tail	1.3	4.6	11.1	-2.7	-3.3	-2.0	-1.9	2.3	-2.4	-2.2	-1.7	-1.6	1.6	0.7
BMI without tail	3.7	11.3	16.9	-3.9	-4.1	-2.5	-3.5	3.8	-3.9	-3.7	-3.2	-3.2	3.2	-0.3
Body weight	11.4	50.0	82.5	-8.6	-9.1	-6.1	-7.5	7.8	-7.8	-7.7	-6.4	-6.3	6.2	0.3
Weight adjusted by age	0.5	0.8	3.4	-1.2	-1.5	-1.8	-0.5	0.7	-0.2	-0.4	-0.1	-0.1	0.0	1.0
Bone surface	3.0	5.5	10.8	-3.3	-3.3	-2.8	-2.5	2.3	-2.2	-2.3	-1.8	-1.7	1.7	1.0
Bone volume	1.4	2.5	5.9	-2.4	-2.4	-2.3	-1.5	1.3	-1.2	-1.2	-0.8	-0.8	0.8	1.4
Breakpoint value in progressive ratio session	0.8	0.9	1.9	-0.2	-0.0	0.5	-0.7	1.0	-1.1	-1.0	-1.2	-1.2	1.2	-1.4
Number of licking bursts	0.4	0.7	3.2	-1.2	-0.9	-1.8	-0.8	-0.1	0.1	0.1	0.3	0.3	-0.4	1.2
Context. condit. distance diff. score	4.2	5.1	6.9	-2.3	-2.0	-1.2	-2.5	2.4	-2.3	-2.6	-2.6	-2.6	2.6	-1.0
Locomotion velocity, session 1	0.3	0.3	1.2	0.7	1.1	1.0	0.4	-0.0	0.2	-0.1	-0.1	-0.1	0.1	-0.9
Locomotion distance, session 1	0.9	1.1	3.2	1.5	1.8	1.1	1.0	-1.0	1.0	0.9	0.7	0.7	-0.6	-0.6
Locomotion velocity, session 2	0.2	0.2	0.6	0.6	0.7	0.7	0.1	0.0	0.0	-0.0	-0.1	-0.2	0.2	-0.8
Locomotion distance, session 2	1.0	1.4	4.3	1.6	2.1	0.9	0.7	-1.3	1.4	1.3	0.8	0.8	-0.8	-0.4
Locomotion velocity, session 3	0.3	0.3	0.6	-0.5	-0.3	0.0	-0.5	0.7	-0.6	-0.7	-0.7	-0.7	0.7	-0.5
Locomotion distance, session 3	0.3	0.3	0.6	0.1	0.4	-0.5	0.1	-0.7	0.8	0.7	0.6	0.6	-0.6	0.7
Stereotopy head waving bouts, day 3	1.6	1.8	4.5	-2.0	-2.1	-2.1	-1.6	0.9	-1.0	-0.9	-0.7	-0.7	0.7	1.0
Stereotopy head waving duration, day 3	0.1	0.1	0.3	-0.1	-0.3	-0.4	0.2	-0.3	0.2	0.3	0.4	0.4	-0.4	0.5
Locomotion velocity, session 7	1.0	1.1	3.8	0.7	0.7	1.7	0.3	0.7	-0.8	-0.8	-0.8	-0.9	0.9	-1.9
Locomotion distance, session 7	0.5	0.6	2.3	0.5	0.8	1.0	-0.2	0.3	-0.4	-0.4	-0.8	-0.8	0.8	-1.5
Stereotopy head waving bouts, day 7	0.1	0.1	0.5	0.6	0.7	0.5	0.3	-0.3	0.4	0.2	0.1	0.1	-0.1	-0.4
Stereotopy head waving duration, day 7	0.4	0.5	1.1	0.9	1.1	0.8	0.8	-0.5	0.6	0.5	0.5	0.4	-0.4	-0.4
Locomotion velocity, session 8	0.5	0.6	0.9	-0.3	-0.3	0.4	-0.5	1.0	-0.9	-1.0	-0.9	-0.9	0.9	-1.0
Locomotion distance, session 8	1.4	2.1	3.0	-1.3	-1.1	-0.5	-1.6	1.6	-1.5	-1.7	-1.7	-1.7	1.7	-0.9
Degree of sensitization distance	0.6	0.6	2.1	1.1	1.1	1.4	0.5	-0.1	-0.0	0.1	-0.2	-0.2	0.3	-1.4
Degree of sensitization stereotypy	0.3	0.3	0.9	0.7	1.0	0.9	0.6	-0.1	0.3	0.1	0.1	0.1	-0.1	-0.6
Conditioned locomotion	0.3	0.3	0.7	-0.1	-0.1	-0.5	0.4	-0.7	0.7	0.6	0.6	0.7	-0.7	0.9
Cocaine response after cond. corrected	0.2	0.3	0.8	-0.4	-0.9	-0.3	0.9	0.1	-0.3	-0.2	0.5	0.5	-0.5	0.8
Cocaine response after cond. not corrected	0.2	0.2	0.5	-0.2	-0.7	0.2	0.6	0.6	-0.7	-0.5	-0.1	-0.1	0.1	0.1
Cocaine response before conditioning	0.9	1.0	2.1	0.2	0.3	0.9	-0.9	0.9	-0.8	-0.7	-1.4	-1.4	1.4	-1.4
Saline control response	1.8	2.4	6.9	-2.0	-1.6	-2.2	-2.6	1.0	-0.9	-1.0	-1.3	-1.2	1.2	0.4
Bone: connectivity density	4.0	6.2	12.6	-3.5	-3.4	-3.3	-3.0	2.1	-2.0	-2.1	-1.8	-1.8	1.7	1.3
Bone: cortical apparent density	0.2	0.3	1.3	0.6	0.5	1.2	0.5	0.1	-0.2	-0.1	-0.1	-0.1	0.2	-0.9
Bone: cortical area	3.1	4.8	7.4	-1.8	-1.9	-0.4	-2.0	2.7	-2.6	-2.7	-2.5	-2.5	2.5	-1.3
Bone: cortical porosity	0.1	0.1	0.3	-0.2	-0.2	-0.5	-0.2	-0.3	0.2	0.3	0.2	0.2	-0.2	0.5
Bone: cortical porosity	0.1	0.1	0.2	0.4	0.4	0.2	0.1	-0.5	0.4	0.5	0.2	0.2	-0.2	-0.0
Bone: cortical thickness	2.3	3.8	5.5	-1.8	-1.9	-0.6	-1.9	2.3	-2.3	-2.3	-2.1	-2.1	2.1	-1.0
Bone: cortical thickness	1.5	1.8	3.0	-1.2	-1.2	-0.7	-1.7	1.4	-1.5	-1.4	-1.5	-1.5	1.5	-0.6
Bone: cortical tissue density	0.2	0.3	1.2	0.7	0.6	1.1	0.6	-0.0	-0.1	0.0	0.0	0.0	-0.0	-0.8
Condit. Reinf. active minus inactive responses	0.4	0.4	1.6	0.9	0.9	1.3	0.9	-0.2	0.2	-0.0	0.1	0.1	-0.1	-0.8
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.2	0.4	0.3	1.1	0.5	0.4	-0.3	-0.5	-0.4	-0.4	0.4	-1.0
Condit. Reinf. active responses	0.3	0.4	1.2	0.9	1.1	1.1	0.5	-0.3	0.3	0.1	-0.1	-0.1	0.1	-0.8
Condit. Reinf. inactive responses	0.5	0.6	2.3	1.2	1.5	0.8	0.3	-0.8	0.7	0.7	0.2	0.2	-0.2	-0.6
Incentive salience index mean	0.4	0.4	1.3	1.0	1.1	1.1	0.7	-0.4	0.4	0.2	0.1	0.1	-0.1	-0.7
Condit. Reinf. lever presses	0.2	0.3	1.0	0.9	1.0	0.8	0.4	-0.6	0.5	0.4	0.1	0.1	-0.1	-0.5
Condit. Reinf. active minus inactive responses	2.4	3.2	4.7	-1.2	-0.9	0.0	-1.8	2.1	-2.0	-2.1	-2.2	-2.2	2.2	-1.6
Condit. Reinf. active-inactive response ratio	1.4	1.6	2.5	-0.4	-0.2	0.4	-1.2	1.5	-1.5	-1.4	-1.6	-1.6	1.6	-1.6
Condit. Reinf. active responses	2.8	3.8	6.0	-1.3	-1.0	0.0	-2.0	2.2	-2.1	-2.2	-2.4	-2.4	2.4	-1.8
Condit. Reinf. inactive responses	0.5	0.7	1.0	-0.8	-0.6	-0.4	-1.0	0.8	-0.7	-0.9	-1.0	-1.0	1.0	-0.4
Condit. Reinf. lever presses	0.4	0.6	1.1	-0.3	-0.0	0.2	-0.7	0.8	-0.7	-0.8	-1.1	-1.1	1.1	-0.8
Condit. Reinf. lever reinforcers received	2.2	3.0	5.0	-0.9	-0.5	0.2	-1.8	1.9	-1.8	-2.0	-2.2	-2.2	2.2	-1.9
Conditioned reinforcement - actives	2.2	3.7	6.0	-2.4	-1.8	-1.7	-2.4	2.0	-2.1	-2.2	-1.8	-1.8	1.8	-0.0
Conditioned reinforcement - inactives	0.2	0.3	1.4	-0.5	-0.4	-1.2	-0.6	-0.2	0.0	0.3	0.3	0.3	-0.3	1.1
Conditioned locomotion	2.0	2.6	5.0	-1.7	-1.2	-1.2	-2.2	1.6	-1.7	-1.7	-1.8	-1.8	1.8	-0.4
Patch foraging indifference point 0 sec	1.1	2.0	4.6	-0.2	-0.1	-1.9	0.4	-1.5	1.6	1.3	1.5	1.5	-1.6	2.1
Patch foraging indifference point AUC	0.7	0.9	2.0	-1.4	-1.3	-1.2	-1.4	0.9	-0.8	-0.7	-0.6	-0.6	0.6	0.6
Delay disc. indifference point, 0s delay	2.8	3.1	5.9	-0.4	-1.1	1.9	-0.4	2.2	-2.4	-2.1	-1.8	-1.8	1.8	-2.0
Delay disc. indifference point, 16s delay	0.6	0.6	3.8	0.6	0.5	2.0	0.2	0.4	-0.4	-0.3	-0.5	-0.5	0.5	-1.1
Delay disc. indifference point, 2s delay	2.6	2.8	14.5	1.8	1.4	3.8	1.0	0.6	-0.7	-0.6	-0.8	-0.9	0.9	-2.7
Delay disc. indifference point, 24s delay	0.5	0.6	2.8	1.0	1.0	1.7	0.7	-0.2	0.2	0.1	0.1	0.0	-0.0	-0.9
Delay disc. indifference point, 4s delay	1.4	1.5	7.4	1.2	0.8	2.7	0.5	0.6	-0.6	-0.6	-0.7	-0.7	0.8	-1.8
Delay disc. indifference point, 8s delay	0.6	0.7	3.2	0.9	0.7	1.8	-0.0	0.3	-0.4	-0.2	-0.5	-0.6	0.6	-1.3
Indifference point function ln k	0.1	0.2	0.4	0.0	0.5	-0.6	-0.1	-0.6	0.6	0.4	0.2	0.2	-0.2	0.3
Indifference point function log k	0.1	0.2	0.4	0.0	0.5	-0.6	-0.1	-0.6	0.6	0.4	0.2	0.2	-0.2	0.3
Patch foraging total patch changes 0 sec	1.5	2.7	6.2	-0.1	0.1	-2.1	0.5	-1.8	1.9	1.6	1.8	1.8	-1.8	2.5
Patch foraging total patch changes 12 sec	0.5	0.7	2.6	-0.8	-0.9	-1.4	-0.1	-0.2	0.4	0.2	0.6	0.6	-0.6	1.6
Patch foraging total patch changes 18 sec	1.1	1.7	5.3	-0.6	-0.4	-1.9	0.2	-1.1	1.3	1.0	1.4	1.4	-1.4	2.3
Patch foraging total patch changes 24 sec	0.7	1.2	2.7	0.2	0.5	-1.3	-0.2	-1.3	1.4	1.4	1.0	1.1	-1.0	1.6
Patch foraging total patch changes 6 sec	0.9	1.3	4.4	-0.6	-0.6	-1.8	-0.1	-1.0	1.1	0.8	1.0	1.1	-1.1	2.1
Patch foraging time to switch 0 sec	0.7	1.4	6.7	1.4	0.4	2.6	2.3	0.1	-0.3	-0.1	0.4	0.4	-0.4	-1.0
Patch foraging water rate 0 sec	1.3	2.7	14.0	-2.0	-1.2	-3.7	-2.3	-0.2	0.3	0.0	-0.2	-0.2	0.2	2.0
Patch foraging water rate 12 sec	0.2	0.4	2.3	-0.2	0.1	-1.5	-1.2	-0.4	0.3	0.3	-0.2	-0.2	0.2	0.4
Patch foraging water rate 18 sec	0.2	0.4	0.8	0.7	0.9	0.4	-0.8	-0.2	0.1	0.2	-0.6	-0.6	0.7	-0.9
Patch foraging water rate 24 sec	1.1	1.5	4.8	-1.5	-1.2	-2.0	-2.2	0.6	-0.7	-0.6	-1.0	-0.9	0.9	0.6
Patch foraging water rate 6 sec	0.3	0.4	2.5	-0.5	0.0	-1.6	-1.1	-0.3	0.3	0.2	-0.3	-0.2	0.2	0.7
Seeking ratio, delayed vs. immediate footshock	3.1	3.7	5.4	1.4	1.6	-0.1	1.9	-2.1	2.3	2.2	2.3	2.3	-2.3	1.5
Distance traveled before self-admin	0.5	0.7	1.7	1.3	1.3	1.3	0.9	-0.6	0.6	0.5	0.1	0.1	-0.1	-0.9
Distance traveled after self-admin	0.2	0.2	0.8	0.4	0.9	0.9	-0.1	-0.2	0.3	0.2	-0.2	-0.2	0.2	-0.7
Extensor digitorum longus weight	4.8	18.8	26.3	-5.0	-5.1	-3.3	-5.1	4.6	-4.6	-4.5	-4.4	-4.3	4.3	-0.5
Bone: elastic displacement	0.2	0.3	0.6	-0.8	-0.6	-0.8	-0.6	0.4	-0.3	-0.4	-0.3	-0.3	0.3	0.3
Bone: elastic work	2.8	3.6	6.7	-2.6	-2.5	-2.3	-2.4	1.8	-1.7	-1.7	-1.5	-1.5	1.5	0.6
Bone: endosteal estimation	0.5	1.1	4.2	-1.6	-1.3	-2.0	-1.4	0.4	-0.2	-0.5	-0.3	-0.2	0.2	1.3
Bone: endosteal perimeter	0.6	1.2	2.4	-1.3	-1.0	-1.1	-1.6	1.1	-0.8	-1.2	-1.2	-1.2	1.2	0.0
Epididymis fat weight	0.0	0.0	0.1	0.1	-0.0	0.1	-0.1	0.1	-0.2	-0.0	-0.3	-0.3	0.3	-0.3
Delta time in closed arm before/after self-admin	1.1	1.0	2.9	-0.1	-0.2	1.7	-0.8	0.8	-0.9	-0.8	-1.0	-1.0	1.0	-1.4
Delta time in open arm before/after self-admin	2.2	2.2	4.2	1.8	1.8	-0.5	2.0	-1.5	1.7	1.5	1.4	1.4	-1.4	0.2
Diff in mean of infusions in LGA sessions	0.2	0.2	0.3	-0.5	-0.3	-0.5	-0.5	0.4	-0.6	-0.4	-0.5	-0.5	0.5	-0.0
Delay discount exponential model param	2.0	2.3	12.1	-1.5	-1.2	-3.5	-0.5	-0.6	0.7	0.6	0.8	0.9	-0.9	2.3
Extinction: sum of active levers before priming	0.2	0.2	1.1	0.5	0.4	1.0	0.4	0.1	-0.2	-0.2	-0.3	-0.3	0.3	-0.8
Active lever presses in extinction session 6	0.1	0.1	0.4	-0.5	-0.3	-0.6	-0.2	0.1	-0.2	-0.1	-0.1	-0.1	0.1	0.4
Bone: final force	2.8	4.5	5.9	-2.4	-2.4	-1.5	-2.4	2.4	-2.4	-2.4	-2.0	-2.0	2.0	-0.5
Bone: final moment	2.2	3.5	4.7	-2.2	-2.2	-1.4	-2.1	2.1	-2.1	-2.1	-1.8	-1.8	1.7	-0.3
Food consumed during 24 hour testing period	0.4	0.5	1.9	-0.6	-0.5	-1.3	-0.2	-0.3	0.3	0.1	0.5	0.5	-0.5	1.4
Glucose	0.8	1.2	4.3	1.6	1.5	2.1	1.3	-0.5	0.5	0.4	0.4	0.3	-0.3	-1.1
Heart weight	0.4	0.7	2.0	-0.3	0.1	-0.3	-1.4	0.6	-0.6	-0.7	-1.1	-1.1	1.1	-0.8
Delay discount hyperbolic model param	2.0	2.2	11.7	-1.4	-1.1	-3.4	-0.5	-0.6	0.7	0.6	0.9	0.9	-0.9	2.3
Intermittent access intake day 1-15 change	0.5	1.0	3.7	-1.5	-1.3	-1.9	-1.1	0.4	-0.6	-0.4	-0.0	-0.0	-0.0	1.4
Intermittent access intake escalation	0.5	1.0	3.6	-1.4	-1.3	-1.9	-1.0	0.3	-0.5	-0.4	0.0	0.0	-0.1	1.4
Intermittent access intake escalation 2	0.3	0.3	1.1	-0.4	-0.3	-0.8	0.1	-0.4	0.4	0.3	0.6	0.6	-0.6	1.0
Intermitt. access day 1 inactive lever presses	0.1	0.4	1.4	-0.4	-0.3	-1.0	-0.3	-0.5	0.4	0.5	0.6	0.6	-0.6	1.2
Intermitt. access day 15 inactive lever presses	0.3	0.5	1.3	-0.0	-0.3	-0.0	1.1	-0.4	0.4	0.5	0.9	0.9	-0.9	1.2
Intermitt. access escalation Index	0.2	0.2	0.7	0.6	0.9	0.7	0.0	-0.4	0.4	0.3	-0.1	-0.1	0.1	-0.7
Intermittent access day 1 total infusions	0.4	0.7	2.8	0.9	1.7	1.5	0.2	-0.4	0.4	0.2	-0.2	-0.2	0.2	-1.2
Intermittent access day 15 total infusions	0.1	0.1	0.3	-0.1	0.5	0.0	-0.5	-0.0	-0.1	-0.2	-0.3	-0.3	0.3	-0.3
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.2	-0.0	0.4	0.3	-0.2	0.0	-0.1	-0.3	-0.2	-0.2	0.2	-0.3
Intermittent access total infusions	0.4	0.4	1.3	0.4	0.8	1.1	-0.0	0.3	-0.2	-0.5	-0.6	-0.6	0.6	-1.1
Intermittent access day 1 locomotion	0.8	1.0	3.1	1.3	1.7	1.7	0.4	-0.4	0.4	0.3	-0.3	-0.3	0.3	-1.4
Intermittent access day 15 total locomotion	0.1	0.3	0.9	0.1	0.8	-0.1	-0.9	-0.2	0.4	0.1	-0.5	-0.5	0.5	-0.5
Intermittent access total locomotion	0.5	0.6	1.8	0.8	1.4	1.1	-0.1	-0.3	0.3	0.1	-0.5	-0.4	0.5	-1.2
Intermittent access standard deviation	0.3	0.7	2.7	-0.5	-0.7	-0.9	0.4	-0.3	0.3	0.4	0.9	0.9	-0.9	1.6
Left kidney weight	6.8	31.5	56.3	-7.5	-7.5	-6.4	-6.4	5.6	-5.4	-5.5	-4.5	-4.4	4.4	1.6
Right kidney weight	5.8	26.6	48.9	-6.9	-7.0	-5.7	-5.7	5.3	-5.1	-5.0	-4.1	-4.1	4.0	1.3
Cocaine induced anxiety	0.3	0.5	1.3	0.4	0.4	1.1	-0.0	0.4	-0.6	-0.5	-0.7	-0.7	0.8	-1.1
Post-drug Anxiety	2.1	2.3	10.9	1.8	1.3	3.3	1.8	0.5	-0.5	-0.4	-0.3	-0.4	0.4	-2.2
Baseline Anxiety	1.3	1.6	6.1	1.6	1.1	2.5	2.2	-0.2	0.3	0.3	0.7	0.7	-0.7	-0.9
Tail length	8.0	31.2	44.5	-6.7	-6.4	-4.7	-6.4	6.1	-6.0	-6.0	-5.4	-5.3	5.3	-0.6
Length with tail	14.4	62.6	94.3	-9.7	-9.6	-7.2	-9.0	8.6	-8.3	-8.4	-7.3	-7.2	7.1	-0.0
Length without tail	7.7	24.9	48.8	-6.8	-7.0	-5.8	-5.4	5.1	-4.8	-5.0	-3.7	-3.7	3.6	1.7
Times rat made contact with spout	1.0	1.2	1.7	-1.1	-0.9	-0.7	-1.2	1.2	-1.2	-1.3	-1.2	-1.2	1.2	-0.4
Lifetime Intake	0.3	0.4	1.8	0.6	1.0	1.3	0.4	0.0	-0.0	-0.2	-0.2	-0.2	0.3	-0.9
Liver weight, left	2.6	4.4	16.0	-3.1	-3.0	-4.0	-2.1	0.5	-0.6	-0.6	-0.1	-0.0	-0.0	2.8
Liver weight, right	1.7	2.9	6.0	-2.4	-2.5	-2.2	-2.0	1.5	-1.4	-1.4	-1.2	-1.1	1.1	0.9
Locomotor activity	2.1	3.3	7.0	-1.7	-1.3	-0.9	-2.6	1.7	-1.7	-1.8	-2.1	-2.1	2.1	-1.1
Locomotor testing distance	0.4	0.7	2.8	-1.3	-0.9	-1.7	-1.3	0.3	-0.2	-0.4	-0.4	-0.4	0.4	0.4
Locomotor testing rearing	0.4	0.8	1.5	-0.1	0.0	-1.2	0.4	-1.0	1.1	0.9	0.9	1.0	-1.0	1.1
Locomotion in novel chamber	0.5	0.7	2.5	-0.9	-0.3	-1.5	-1.6	0.2	-0.3	-0.2	-0.6	-0.6	0.6	0.2
Locomotion in novel chamber post-restriction	1.2	2.0	4.9	-1.3	-0.9	-1.1	-2.2	1.3	-1.3	-1.2	-1.6	-1.6	1.6	-0.6
Fecal boli incidents, locomotor time 1	1.6	2.4	4.0	-1.7	-1.4	-1.1	-2.0	1.5	-1.7	-1.6	-1.7	-1.7	1.7	-0.5
Change in fecal boli incidents, locomotor task	0.2	0.2	0.6	0.2	0.0	0.0	0.8	-0.2	0.2	0.1	0.6	0.6	-0.6	0.3
Time >=10cm from walls, locomotor time 1	0.9	1.0	4.7	1.2	1.2	2.2	1.2	0.0	-0.1	-0.1	-0.1	-0.1	0.1	-1.4
Bouts of movement, locomotor time 1	1.1	1.2	2.4	-1.4	-1.2	-0.8	-1.5	1.1	-1.1	-1.0	-1.1	-1.1	1.0	0.2
Total resting periods, locomotor time 1	1.1	1.2	2.4	-1.4	-1.2	-0.6	-1.5	1.1	-1.2	-1.1	-1.1	-1.1	1.1	0.0
Rest time, locomotor task time 1	1.3	1.7	2.6	-1.6	-1.5	-0.8	-1.4	1.4	-1.5	-1.4	-1.2	-1.2	1.2	0.1
Distance moved, locomotor task time 1	0.3	0.5	1.6	1.1	1.0	1.3	0.5	-0.4	0.5	0.4	0.2	0.1	-0.1	-0.9
Vertical activity count, locomotor time 1	0.1	0.2	1.0	0.1	-0.0	1.0	-0.6	0.2	-0.2	-0.1	-0.5	-0.5	0.5	-0.6
Time >=10cm from walls, locomotor time 2	1.2	1.7	3.1	-0.7	-0.8	1.2	-0.5	1.6	-1.8	-1.6	-1.4	-1.4	1.4	-1.3
Bouts of movement, locomotor time 2	0.6	1.0	2.0	-1.2	-1.3	-0.8	-1.4	0.9	-1.0	-0.9	-1.0	-1.0	1.0	0.1
Total resting periods, locomotor time 2	0.5	0.9	1.7	-1.2	-1.3	-1.0	-1.2	0.8	-0.9	-0.8	-0.8	-0.8	0.8	0.4
Rest time, locomotor task time 2	0.1	0.1	0.2	0.3	0.5	-0.5	0.5	-0.3	0.3	0.3	0.2	0.2	-0.2	0.1
Distance moved, locomotor task time 2	0.1	0.1	0.3	-0.3	-0.4	0.5	-0.4	0.1	-0.0	-0.1	0.1	0.1	-0.1	0.2
Vertical activity count, locomotor time 2	0.9	1.2	3.3	-1.6	-1.7	-0.3	-1.8	0.8	-1.0	-0.9	-0.8	-0.8	0.8	0.4
Light reinforcement 1	0.5	1.2	4.1	1.5	1.3	2.0	0.6	0.2	-0.2	-0.2	-0.5	-0.5	0.6	-2.0
Light reinforcement 2	0.2	0.4	0.7	0.6	0.7	0.2	0.5	-0.7	0.5	0.8	0.7	0.7	-0.7	0.3
Bone: marrow area	0.5	1.1	4.2	-1.5	-1.2	-2.0	-1.3	0.4	-0.1	-0.4	-0.2	-0.2	0.1	1.4
Bone: maximum diameter	1.3	2.4	3.5	-1.9	-1.9	-1.2	-1.7	1.8	-1.6	-1.9	-1.5	-1.4	1.4	0.1
Bone: maximum force	2.0	3.5	5.2	-2.2	-2.2	-1.6	-2.3	2.0	-1.9	-2.0	-1.8	-1.8	1.8	-0.2
Bone: maximum moment	1.5	2.7	4.2	-2.0	-2.0	-1.6	-2.1	1.7	-1.6	-1.6	-1.5	-1.5	1.5	-0.0
Mean time between licks in bursts	1.0	2.5	3.8	1.8	1.9	1.0	1.6	-1.8	1.7	2.0	1.5	1.5	-1.5	0.2
Mean num. licks in bursts	0.2	0.3	0.6	0.2	0.1	0.8	0.0	0.5	-0.5	-0.5	-0.6	-0.6	0.6	-0.8
Cd content in liver	0.3	0.4	1.1	0.5	0.9	0.5	-0.6	0.1	0.0	0.2	-0.6	-0.6	0.6	-1.1
Co content in liver	1.4	1.7	5.0	-0.6	-0.5	-2.2	-0.3	-1.0	1.0	1.2	1.2	1.2	-1.3	2.2
Cu content in liver	0.2	0.2	0.4	0.1	0.7	-0.4	0.3	-0.5	0.6	0.4	0.4	0.4	-0.4	0.3
Fe content in liver	0.8	0.9	1.8	-0.6	-0.2	-0.3	-1.1	0.8	-0.8	-1.0	-1.3	-1.3	1.4	-0.9
K content in liver	0.1	0.1	0.3	-0.2	-0.2	0.4	0.2	0.5	-0.4	-0.5	-0.4	-0.4	0.4	-0.3
Mg content in liver	0.4	0.4	0.8	-0.9	-0.9	-0.4	-0.5	0.7	-0.7	-0.9	-0.4	-0.4	0.4	0.3
Mn content in liver	0.3	0.3	0.6	0.3	0.3	0.1	0.7	-0.5	0.6	0.7	0.8	0.8	-0.8	0.6
Na content in liver	0.7	0.8	1.3	-1.0	-1.1	-0.4	-0.8	1.0	-1.0	-1.2	-0.8	-0.8	0.8	-0.1
Rb content in liver	2.3	2.7	5.5	2.3	2.3	2.0	2.0	-1.6	1.5	1.3	1.1	1.1	-1.1	-0.6
Se content in liver	2.6	3.1	5.1	-0.9	-1.2	0.7	-0.7	2.2	-2.2	-2.3	-2.1	-2.1	2.1	-1.7
Sr content in liver	0.5	0.4	1.4	-0.6	-0.6	-1.1	-0.4	-0.1	0.1	0.2	0.5	0.5	-0.5	1.2
Zn content in liver	2.2	2.4	6.6	-2.5	-2.1	-2.6	-1.9	0.9	-0.9	-1.0	-0.5	-0.5	0.4	1.7
Bone: minimum diameter	0.0	0.0	0.0	0.1	0.2	0.0	-0.0	0.0	0.2	-0.2	0.0	0.0	-0.0	-0.0
Time in familiar zone, hab. session 1	1.4	1.3	2.2	0.3	0.1	-0.4	1.1	-1.2	1.2	1.3	1.5	1.5	-1.5	1.4
Time in novel zone, hab. session 1	1.1	1.1	1.8	-0.7	-0.6	0.0	-1.0	1.2	-1.2	-1.3	-1.2	-1.2	1.2	-0.9
Total zone transitions, hab. session 1	0.9	1.2	3.8	1.8	1.9	1.5	0.8	-0.8	0.8	0.7	0.3	0.3	-0.2	-1.2
Total locomotion distance, hab. session 1	0.4	0.6	2.0	1.2	1.1	1.4	0.6	-0.2	0.1	0.1	-0.1	-0.1	0.2	-1.2
Locomotion velocity, hab. session 1	0.9	1.3	3.7	1.9	1.8	1.9	1.0	-0.6	0.5	0.5	0.1	0.1	-0.0	-1.4
Time in familiar zone, hab. session 2	0.1	0.1	0.3	0.1	-0.3	0.3	0.6	0.0	-0.0	0.1	0.3	0.3	-0.3	0.2
Time in novel zone, hab. session 2	0.1	0.1	0.7	0.4	0.8	0.4	-0.0	-0.2	0.3	-0.0	-0.1	-0.1	0.1	-0.5
Total zone transitions, hab. session 2	0.1	0.1	0.3	-0.3	-0.1	-0.2	-0.6	0.4	-0.3	-0.3	-0.4	-0.4	0.4	-0.3
Total locomotion distance, hab. session 2	0.1	0.2	0.5	0.6	0.7	0.6	0.2	-0.2	0.3	0.2	0.0	0.0	-0.0	-0.5
Locomotion velocity, hab. session 2	0.1	0.2	0.5	0.7	0.7	0.5	0.2	-0.3	0.3	0.3	0.1	0.1	-0.1	-0.5
Novel to familiar place preference ratio	0.0	0.0	0.2	0.1	0.2	0.2	-0.1	0.1	-0.1	-0.2	-0.1	-0.1	0.1	-0.4
Novelty place preference	0.1	0.1	0.4	0.5	0.6	0.5	0.2	-0.2	0.2	0.1	0.1	0.1	-0.1	-0.4
Time in novel zone, NPP test	0.0	0.0	0.2	0.2	0.4	0.3	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	-0.4
Total zone transitions, NPP test	0.1	0.2	0.3	-0.1	0.2	0.1	-0.4	0.4	-0.3	-0.4	-0.5	-0.5	0.5	-0.6
Total locomotion distance, NPP test	0.6	0.8	2.3	0.5	0.6	1.2	-0.1	0.7	-0.6	-0.8	-0.9	-0.9	1.0	-1.5
Locomotion velocity, NPP test	0.5	0.8	2.2	0.4	0.6	0.9	-0.4	0.6	-0.5	-0.7	-1.0	-1.0	1.1	-1.5
Intraocular pressure	0.9	1.4	2.9	-1.6	-1.4	-1.5	-1.7	0.9	-0.7	-0.9	-1.0	-1.0	1.0	0.5
Delta distance traveled before/after self-admin	0.2	0.2	0.7	-0.7	-0.3	-0.9	-0.7	0.0	0.1	0.0	0.1	0.1	-0.1	0.7
Delta ambulatory time before/after self-admin	0.3	0.3	0.5	0.1	0.4	-0.2	0.2	-0.6	0.7	0.7	0.7	0.7	-0.7	0.6
Parametrial fat weight	0.1	0.2	0.9	-0.4	-1.0	0.1	0.4	0.6	-0.8	-0.6	-0.1	-0.1	0.1	0.1
Pavlov. Cond. lever latency	1.6	2.0	4.6	-2.1	-2.1	-2.0	-1.6	1.1	-1.1	-1.1	-0.7	-0.7	0.7	1.0
Pavlov. Cond. magazine entry latency	0.6	0.7	1.1	-0.5	-0.5	0.1	-0.9	1.0	-1.0	-0.9	-1.0	-1.0	1.0	-0.8
Pavlov. Cond. change in total contacts	0.8	0.8	2.7	0.8	0.5	1.6	0.5	0.6	-0.7	-0.7	-0.6	-0.6	0.7	-1.6
Pavlov. Cond. index score	0.2	0.3	0.9	0.5	0.4	0.9	0.2	0.3	-0.3	-0.3	-0.4	-0.4	0.5	-1.0
Pavlov. Cond. latency score	0.4	0.4	1.6	0.8	0.8	1.3	0.4	0.2	-0.2	-0.2	-0.4	-0.4	0.4	-1.2
Pavlov. Cond. lever contacts	1.2	1.4	3.5	1.8	1.8	1.9	1.4	-0.8	0.7	0.8	0.5	0.5	-0.5	-1.0
Pavlov. Cond. magazine entry number	0.6	0.8	1.3	0.4	0.3	-0.2	0.9	-1.0	1.0	0.9	1.2	1.1	-1.2	1.0
Pavlov. Cond. intertrial magazine entries	1.1	1.3	2.0	1.2	1.4	0.4	1.1	-1.4	1.4	1.2	1.1	1.1	-1.1	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.8	0.4	0.3	0.9	0.2	0.4	-0.4	-0.3	-0.4	-0.4	0.4	-0.9
Pavlov. Cond. response bias	0.4	0.4	0.9	-0.0	0.0	0.4	-0.5	0.7	-0.7	-0.6	-0.8	-0.8	0.9	-0.9
Pavlov. Cond. lever latency	0.6	0.8	2.2	-0.6	-0.7	-1.3	0.3	-0.7	0.5	0.6	1.0	1.0	-1.0	1.5
Pavlov. Cond. magazine entry latency	1.3	1.5	5.5	1.6	1.6	2.4	0.9	0.2	-0.1	-0.1	-0.5	-0.5	0.5	-2.1
Pavlov. Cond. change in total contacts	0.3	0.5	1.7	0.6	1.0	0.9	-0.3	0.2	-0.1	-0.3	-0.7	-0.7	0.7	-1.3
Pavlov. Cond. index score	0.8	1.1	3.3	1.3	1.5	1.8	0.3	0.2	-0.0	-0.1	-0.6	-0.6	0.7	-1.8
Pavlov. Cond. latency score	0.8	1.0	3.2	1.3	1.4	1.8	0.4	0.2	-0.1	-0.2	-0.6	-0.6	0.7	-1.8
Pavlov. Cond. lever contacts	0.7	1.0	2.9	0.8	0.9	1.5	-0.2	0.7	-0.6	-0.6	-1.0	-1.0	1.1	-1.7
Pavlov. Cond. magazine entry number	1.0	1.2	3.5	-1.7	-1.8	-1.9	-0.8	0.2	-0.2	-0.2	0.2	0.2	-0.3	1.7
Pavlov. Cond. intertrial magazine entries	0.4	0.6	1.5	-1.1	-1.0	-1.0	-1.2	0.6	-0.6	-0.7	-0.6	-0.6	0.6	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	3.8	1.4	1.6	1.9	0.3	0.2	-0.1	-0.1	-0.7	-0.7	0.7	-1.9
Pavlov. Cond. response bias	1.1	1.5	4.7	1.4	1.5	2.0	0.1	0.4	-0.3	-0.4	-1.0	-1.0	1.0	-2.2
Time in closed arm before self-admin	1.1	1.4	4.4	-1.6	-1.4	-2.1	-1.7	0.8	-0.8	-0.8	-0.7	-0.7	0.7	0.9
Time in closed arm after self-admin	1.1	1.2	4.2	-1.2	-1.1	-0.4	-2.1	0.8	-0.9	-0.8	-1.2	-1.2	1.2	-0.4
Time in open arm before self-admin	0.5	0.6	2.9	0.2	0.4	1.7	-0.3	0.3	-0.4	-0.4	-0.6	-0.6	0.7	-1.1
Time in open arm after self-admin	0.6	0.7	2.2	1.1	1.1	0.6	1.5	-0.6	0.6	0.6	0.6	0.6	-0.6	-0.3
Bone: periosteal estimation	1.5	3.1	4.5	-2.1	-2.0	-1.5	-2.1	1.9	-1.8	-1.9	-1.7	-1.7	1.7	0.0
Bone: periosteal perimeter	1.2	2.1	3.3	-0.9	-0.8	-0.1	-1.6	1.6	-1.5	-1.7	-1.8	-1.8	1.8	-1.1
Bone: post-yield work	0.1	0.1	0.3	-0.4	-0.4	-0.6	-0.6	0.2	-0.1	-0.2	-0.3	-0.3	0.3	0.1
Progressive ratio test 1 active lever presses	0.9	1.2	1.9	-1.2	-0.8	-0.5	-1.3	1.2	-1.2	-1.4	-1.1	-1.1	1.1	-0.4
Progressive ratio test 1 breakpoint	1.0	1.2	2.0	-1.2	-0.8	-0.5	-1.3	1.2	-1.2	-1.4	-1.2	-1.2	1.2	-0.4
Progressive ratio test 1 inactive lever presses	0.3	0.5	2.1	-0.9	-0.4	-1.4	-1.1	-0.1	0.1	0.1	0.0	0.0	-0.0	1.0
Progressive ratio test 2 active lever presses	0.6	0.7	2.0	-0.9	-0.5	-0.8	-1.4	0.7	-0.8	-0.8	-0.9	-0.9	0.8	-0.1
Progressive ratio test 2 breakpoint	0.5	0.6	1.9	-0.8	-0.5	-0.7	-1.4	0.7	-0.7	-0.8	-0.8	-0.8	0.8	-0.1
Progressive ratio test 2 inactive lever presses	1.0	1.7	6.0	-1.8	-1.3	-2.4	-2.1	0.5	-0.5	-0.5	-0.6	-0.6	0.5	1.3
Incentive Sensitization - Responses	0.0	0.1	0.1	0.4	0.2	-0.0	0.0	-0.3	0.2	0.4	0.2	0.2	-0.2	0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	0.5	0.3	0.0	0.1	-0.4	0.4	0.5	0.3	0.3	-0.3	0.2
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	-0.3	-0.4	-0.6	0.2	0.6	-0.5	-0.6	-0.3	-0.3	0.3	-0.1
Progressive ratio	0.5	0.8	1.3	0.9	1.1	0.7	0.9	-1.1	0.9	1.0	0.9	0.9	-0.9	0.1
Food seeking constrained by brief footshock	3.2	3.9	5.8	1.0	1.1	-0.2	1.7	-2.4	2.3	2.3	2.4	2.4	-2.4	2.0
Seeking ratio, punishment vs. effort	0.3	0.4	1.3	-0.9	-1.0	-1.2	-0.6	0.5	-0.3	-0.4	-0.2	-0.2	0.1	0.7
Retroperitoneal fat weight	0.2	0.8	2.0	0.2	-0.4	1.4	0.8	1.1	-1.0	-1.0	-0.7	-0.7	0.7	-1.0
Reaction time number correct	0.3	0.6	2.2	-0.9	-0.5	-1.5	-1.0	-0.2	0.4	0.2	0.2	0.2	-0.2	1.4
Reaction time mean minus median	1.8	4.4	10.3	0.1	0.2	1.6	-1.0	2.2	-2.3	-2.1	-2.6	-2.6	2.6	-3.2
Reaction time mean minus median AUC	0.5	1.1	4.5	1.0	1.1	1.1	-0.1	0.6	-0.6	-0.4	-1.1	-1.1	1.1	-2.1
Reaction time num false alarms	0.5	0.7	2.5	0.7	0.9	1.2	-0.4	0.3	-0.3	-0.4	-0.9	-0.9	0.9	-1.6
Reaction time num false alarms AUC	0.3	0.5	1.4	0.5	0.6	0.9	-0.5	0.2	-0.2	-0.3	-0.8	-0.8	0.8	-1.2
Reaction time trials correct on left	0.3	0.6	2.2	-0.9	-0.5	-1.5	-1.0	-0.2	0.4	0.2	0.2	0.2	-0.2	1.4
Reaction time trials on left	0.3	0.5	1.9	-0.9	-0.5	-1.4	-1.0	-0.1	0.4	0.2	0.1	0.2	-0.2	1.3
Reaction time mean	1.5	2.4	9.5	2.2	1.9	3.1	1.7	-0.0	-0.1	0.1	-0.2	-0.2	0.3	-2.4
Reaction time mean AUC	1.6	2.5	9.9	2.3	2.0	3.1	1.7	-0.2	0.1	0.2	-0.1	-0.1	0.1	-2.3
Median of all reaction times	2.1	3.1	9.6	2.6	2.2	3.1	2.4	-0.9	0.7	0.8	0.8	0.7	-0.7	-1.7
Reaction time omissions	0.7	1.0	4.7	1.2	1.1	2.2	0.5	0.2	-0.3	-0.1	-0.5	-0.5	0.5	-1.6
Reaction time false alarm rate	0.7	0.9	3.5	0.8	0.8	1.4	-0.1	0.4	-0.5	-0.4	-0.9	-0.9	1.0	-1.9
Reaction time premature initiation rate	0.4	0.6	1.8	0.3	0.0	0.2	-0.5	0.6	-0.9	-0.6	-1.0	-1.0	1.0	-1.4
Reaction time premature initiations	0.2	0.3	0.6	-0.1	-0.1	-0.4	-0.8	0.4	-0.5	-0.4	-0.7	-0.7	0.7	-0.6
Std. dev. reaction times	1.3	2.4	7.8	1.1	1.0	2.3	0.3	1.2	-1.2	-1.0	-1.5	-1.5	1.5	-2.8
Reaction time trials completed	0.3	0.5	1.9	-0.9	-0.5	-1.4	-1.0	-0.1	0.4	0.2	0.1	0.2	-0.2	1.3
Reaction time trials AUC	0.2	0.5	1.6	-0.7	-0.2	-1.2	-0.8	-0.3	0.5	0.4	0.3	0.3	-0.3	1.3
Run reversals in cocaine runway, females	0.8	0.8	1.4	1.0	0.8	0.4	1.2	-1.0	0.9	0.9	1.0	1.0	-1.0	0.5
Run reversals in cocaine runway, males	0.4	0.4	0.9	0.3	0.7	0.1	-0.1	-1.0	0.9	0.9	0.5	0.5	-0.5	0.4
Latency to leave start box in cocaine runway	0.1	0.1	0.4	0.2	0.1	0.6	0.3	0.3	-0.3	-0.5	-0.1	-0.1	0.1	-0.4
Latency to leave start box in cocaine runway, F	0.2	0.3	0.7	-0.6	-0.7	0.6	-0.0	0.8	-0.6	-0.8	-0.1	-0.1	0.1	0.1
Latency to leave start box in cocaine runway, M	0.2	0.2	0.7	0.7	0.8	-0.2	0.3	-0.5	0.3	0.2	0.0	0.0	-0.0	-0.5
Std. dev. time between licks in bursts	0.1	0.2	0.6	-0.1	0.1	-0.1	-0.7	0.2	-0.3	-0.1	-0.6	-0.6	0.6	-0.5
Total sessions with >9 infusions	0.2	0.2	0.7	0.4	0.4	0.6	0.8	-0.4	0.2	0.2	0.5	0.5	-0.5	0.1
Short access day 1 total inactive lever presses	0.3	0.5	1.6	-0.4	-0.6	-1.0	0.2	-0.4	0.3	0.5	0.7	0.7	-0.7	1.3
Short access day 10 total inactive lever presses	0.8	2.0	6.8	-1.7	-2.0	-2.6	-0.5	0.2	-0.2	0.0	0.7	0.7	-0.7	2.6
Short access day 1 total infusions	0.9	1.2	2.6	1.0	1.0	1.0	1.6	-1.1	1.0	0.9	1.2	1.2	-1.2	0.4
Short access day 10 total infusions	0.3	0.3	0.8	0.5	0.9	0.9	0.9	-0.6	0.5	0.3	0.4	0.4	-0.4	-0.1
Short access total infusions	0.6	0.7	2.2	0.9	1.0	1.5	1.5	-0.5	0.4	0.3	0.6	0.6	-0.6	-0.3
Short access day 1 locomotion	0.6	0.7	2.6	0.8	1.1	1.6	0.2	0.1	-0.1	-0.2	-0.6	-0.6	0.6	-1.6
Short access day 10 total locomotion	0.3	0.5	0.9	0.1	0.4	-0.5	0.2	-0.8	0.9	0.9	0.8	0.8	-0.8	0.9
Short access total locomotion	0.5	0.6	2.1	1.0	1.2	1.4	0.9	-0.5	0.5	0.3	0.2	0.2	-0.2	-0.8
One hour access (0.3 mA shock)	0.4	0.5	2.4	-0.8	-0.0	-1.4	-1.5	-0.1	0.1	-0.0	-0.3	-0.3	0.3	0.6
Compulsive drug intake	2.0	2.3	3.3	1.8	1.6	1.0	1.5	-1.8	1.8	1.8	1.5	1.5	-1.5	0.2
One hour access (shock baseline)	1.4	2.1	4.6	-1.5	-0.7	-0.9	-2.2	1.3	-1.3	-1.6	-1.7	-1.7	1.7	-0.6
Social response proportion	6.9	7.9	11.2	-2.5	-2.4	-0.7	-3.0	3.3	-3.4	-3.3	-3.1	-3.1	3.1	-1.7
Social responses	1.9	2.5	4.9	-1.5	-1.2	-0.7	-2.2	1.6	-1.7	-1.5	-1.9	-1.9	1.9	-0.7
Social time	1.2	1.6	4.2	2.0	2.0	1.6	1.3	-1.0	0.9	0.9	0.5	0.5	-0.5	-1.4
Soleus weight	1.0	2.9	4.9	-2.2	-2.2	-2.1	-2.2	1.4	-1.4	-1.5	-1.5	-1.5	1.5	0.5
Bone: stiffness	1.0	1.7	2.6	-0.9	-0.8	-0.2	-1.5	1.4	-1.4	-1.4	-1.6	-1.6	1.6	-1.2
Tibialis anterior weight	6.8	23.1	31.3	-5.5	-5.6	-3.4	-5.3	5.2	-5.4	-5.1	-4.9	-4.8	4.8	-0.8
Time to tail flick, vehicle, before self-admin	1.0	1.1	6.0	0.8	0.5	2.4	0.8	0.5	-0.6	-0.6	-0.5	-0.5	0.5	-1.6
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.5	0.1	0.3	-0.1	-0.1	0.3	-0.2	-0.4	-0.5	-0.5	0.5	-0.7
Time to tail flick, test, before self-admin	1.1	1.2	2.4	-1.6	-1.2	-0.1	-1.4	1.3	-1.2	-1.3	-0.8	-0.8	0.8	0.3
Time to tail flick, test, after self-admin	0.2	0.2	0.7	0.5	0.2	0.9	0.5	0.2	-0.2	-0.2	-0.1	-0.1	0.1	-0.8
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	0.2	0.4	-0.7	-0.1	-0.5	0.6	0.4	0.2	0.2	-0.2	0.3
Delta time to tail flick, test, before/after SA	1.0	1.1	2.1	1.4	1.0	-0.2	1.4	-1.2	1.1	1.2	1.0	1.0	-0.9	-0.0
Tibia length	3.6	9.8	20.3	-4.1	-4.5	-2.8	-3.2	3.5	-3.5	-3.3	-2.4	-2.4	2.3	0.6
Ambulatory time before self-admin	0.2	0.4	1.1	0.8	0.7	1.0	0.4	-0.1	0.2	0.1	-0.3	-0.3	0.4	-1.0
Ambulatory time after self-admin	0.2	0.2	0.8	0.5	0.9	0.8	0.2	-0.3	0.5	0.3	-0.0	-0.0	0.0	-0.6
Bone: tissue strength	1.2	1.2	3.2	-0.3	-0.2	-1.2	0.5	-1.0	1.0	1.0	1.3	1.3	-1.3	1.8
Total heroin consumption	1.4	1.7	5.7	2.0	2.4	1.6	1.1	-0.8	0.8	0.8	0.1	0.1	-0.0	-1.7
Bone: trabecular number	2.0	3.4	6.9	-2.6	-2.6	-2.4	-2.1	1.6	-1.5	-1.6	-1.3	-1.3	1.2	1.0
Bone: trabecular spacing	2.4	3.2	5.2	2.3	2.2	1.6	2.2	-1.9	1.8	1.8	1.7	1.7	-1.6	-0.0
Bone: trabecular thickness	3.0	3.7	6.6	-2.5	-2.6	-2.0	-2.2	1.8	-1.9	-1.8	-1.7	-1.7	1.7	0.5
Bone: trabecular tissue density	3.1	4.6	10.8	0.1	-0.1	2.0	-0.9	2.3	-2.4	-2.2	-2.5	-2.5	2.6	-3.3
Water consumed over 24 hours	1.6	2.2	5.5	-2.2	-2.0	-2.3	-1.9	1.0	-1.0	-1.1	-0.8	-0.8	0.7	1.1
Number of responses in last shaping day	0.3	0.3	0.8	0.6	0.9	0.9	0.7	-0.4	0.2	0.3	0.4	0.4	-0.4	-0.2