Stxbp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Stxbp2 0.35 0.16 1.0e-02 0.1 0.08 0.07 0.09 2.7e-03 6.0e-03 1.2e-02 3.4e-03
2 NAcc gene expression Stxbp2 0.1 0.05 2.6e-05 0.05 0.05 0.05 0.05 2.3e-06 7.4e-07 2.3e-06 9.1e-07
3 NAcc alternative polyA NM_031126.1 0.03 0.02 6.8e-03 0.01 0.02 0.02 0.02 1.7e-02 2.0e-03 1.8e-03 2.1e-03
4 Adipose gene expression Stxbp2 0.09 0.05 1.3e-05 0.02 0.03 0.03 0.03 6.0e-03 2.4e-04 2.5e-04 1.4e-04
5 Liver alternative polyA XM_006248783.4 0.07 0.03 1.1e-07 0.05 0.05 0.06 0.05 1.4e-06 1.6e-06 2.8e-07 4.6e-06
6 Liver alternative polyA XM_039089804.1 0.42 0.12 0.0e+00 0.26 0.27 0.28 0.28 3.4e-28 1.8e-30 2.4e-31 5.5e-31
7 BLA alternative polyA XM_039089805.1 0.15 0.09 5.3e-04 0.04 0.04 0.01 0.04 3.1e-03 2.2e-03 5.2e-02 2.7e-03
8 Liver alternative polyA NM_031126.1 0.07 0.03 1.4e-07 0.05 0.05 0.06 0.05 2.2e-06 2.7e-06 2.5e-07 6.6e-06
9 Liver alternative polyA XM_039089805.1 0.45 0.15 0.0e+00 0.24 0.24 0.26 0.25 8.1e-27 1.3e-26 2.7e-28 1.6e-27
10 BLA gene expression Stxbp2 0.13 0.07 6.9e-04 0.07 0.04 0.04 0.05 1.1e-04 3.4e-03 1.9e-03 9.6e-04
11 Eye alternative polyA XM_039089804.1 0.64 0.15 1.2e-04 0.28 0.24 0.23 0.28 3.6e-05 1.2e-04 2.2e-04 3.5e-05
12 PL gene expression Stxbp2 0.09 0.05 2.1e-05 0.05 0.04 0.03 0.04 7.2e-06 3.4e-05 2.4e-04 3.9e-05
13 Brain alternative polyA XM_039089804.1 0.09 0.05 2.0e-06 0.07 0.06 0.05 0.06 1.0e-06 1.1e-06 2.4e-05 2.1e-06
14 Brain alternative polyA XM_039089805.1 0.13 0.06 7.0e-11 0.12 0.09 0.08 0.1 4.9e-11 1.0e-08 8.2e-08 5.6e-10
15 Adipose alternative polyA XM_039089804.1 0.09 0.05 3.2e-06 0.04 0.04 0.04 0.05 4.4e-05 2.1e-05 1.7e-05 4.8e-06
16 PL alternative polyA XM_039089804.1 0.06 0.04 6.7e-04 0.04 0.02 0.03 0.03 1.6e-05 2.0e-03 2.6e-04 1.7e-04
17 Liver alternative polyA XM_006248783.4 0.06 0.03 2.2e-07 0.05 0.05 0.06 0.04 2.6e-06 3.5e-06 9.7e-07 9.5e-06
18 Brain gene expression Stxbp2 0.09 0.06 2.6e-03 0.03 0.01 0.01 0.03 7.7e-04 1.8e-02 1.3e-02 1.6e-03
19 PL alternative polyA XM_039089805.1 0.14 0.07 2.8e-08 0.04 0.06 0.06 0.06 1.0e-05 1.2e-07 1.2e-07 1.6e-07
20 Eye alternative polyA XM_039089805.1 0.62 0.15 9.5e-05 0.22 0.21 0.26 0.23 2.3e-04 4.2e-04 6.3e-05 1.9e-04
21 Liver isoform ratio XM_006248783.4 0.04 0.03 1.9e-05 0.03 0.03 0.03 0.03 9.5e-05 1.8e-04 5.2e-04 2.2e-04
22 Liver isoform ratio XR_595188.3 0.02 0.01 6.1e-03 0 0.01 0 0 9.6e-02 6.4e-02 1.6e-01 1.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bone: apparent density2.33.811.63.1-2.43.4-3.32.4-1.7-1.9-2.11.61.32.11.3-1.31.21.7-1.71.90.80.80.5-2.1-1.0
Area under the delay curve1.41.57.1-1.00.4-2.72.50.0-0.6-0.6-0.2-0.40.70.50.9-0.91.10.6-0.60.31.01.11.02.42.1
BMI with tail2.37.613.13.2-2.62.0-0.42.4-3.1-2.7-2.32.53.13.63.3-3.43.23.2-3.22.41.93.63.20.81.3
BMI without tail3.67.411.33.0-3.21.3-0.72.6-3.3-2.9-2.42.83.12.93.3-3.43.43.2-3.22.32.82.82.61.01.0
Body weight11.749.285.49.2-8.66.2-4.46.7-8.1-7.0-6.47.88.07.78.0-8.07.98.1-8.16.15.97.25.9-0.10.5
Weight adjusted by age0.50.52.41.3-0.91.5-1.40.4-0.3-0.2-0.20.90.20.30.2-0.20.10.1-0.10.1-0.30.1-0.1-1.3-1.1
Bone surface3.56.113.33.6-3.03.5-2.72.7-2.6-2.5-2.52.52.33.02.3-2.32.32.6-2.62.41.52.11.7-1.3-0.4
Bone volume1.93.210.12.8-2.03.2-2.52.1-1.6-1.7-1.91.61.32.31.3-1.31.31.5-1.51.80.51.21.0-1.7-0.5
Breakpoint value in progressive ratio session1.61.73.80.1-0.7-0.61.41.4-1.3-1.6-1.40.41.21.71.3-1.31.31.1-1.11.51.41.21.61.72.0
Number of licking bursts0.80.94.41.1-0.90.1-1.7-1.0-0.10.81.10.80.0-1.5-0.10.0-0.1-0.20.2-1.30.1-0.4-1.3-1.2-2.1
Context. condit. distance diff. score4.75.710.62.0-2.40.4-0.53.2-2.7-3.1-3.32.02.53.02.4-2.42.42.5-2.53.22.41.72.21.01.7
Locomotion velocity, session 10.20.31.3-0.90.5-0.91.1-0.10.20.00.1-0.6-0.10.0-0.10.1-0.10.1-0.10.00.1-0.00.31.00.9
Locomotion distance, session 10.81.13.0-1.71.3-1.61.1-0.91.00.80.8-1.4-1.0-1.1-1.11.0-1.1-1.01.0-0.7-0.6-1.0-0.60.50.4
Locomotion velocity, session 20.20.21.0-0.60.2-1.00.8-0.50.10.30.5-0.3-0.0-0.60.00.00.00.1-0.1-0.50.3-0.1-0.10.80.3
Locomotion distance, session 21.21.74.2-1.91.2-2.10.8-0.91.20.91.0-1.7-1.4-1.6-1.41.4-1.4-1.41.4-1.0-0.4-1.8-1.20.40.1
Locomotion velocity, session 30.40.51.20.3-0.6-0.20.11.1-0.7-1.0-1.10.50.61.00.7-0.70.70.7-0.71.10.70.50.70.50.8
Locomotion distance, session 30.30.41.1-0.40.3-0.5-0.60.10.50.2-0.1-0.5-0.7-0.5-0.80.7-0.8-0.90.9-0.0-0.4-1.0-0.8-0.7-0.4
Stereotopy head waving bouts, day 31.31.54.92.2-1.82.1-1.81.1-1.3-1.2-1.01.21.10.91.2-1.11.21.0-1.00.91.00.80.3-0.9-0.6
Stereotopy head waving duration, day 30.10.11.90.5-0.11.4-0.3-0.30.00.10.30.00.00.00.1-0.00.10.2-0.2-0.3-0.20.3-0.0-0.4-0.4
Locomotion velocity, session 70.91.03.8-0.70.1-1.91.90.1-0.5-0.4-0.20.60.90.60.7-0.80.70.9-0.90.30.61.01.31.91.4
Locomotion distance, session 70.60.86.1-0.7-0.1-2.51.20.7-0.5-0.7-0.80.40.60.50.5-0.40.50.4-0.40.81.00.10.81.51.3
Stereotopy head waving bouts, day 70.40.51.4-1.20.9-0.50.7-0.40.70.40.4-1.1-0.8-0.6-0.80.7-0.8-0.70.7-0.3-0.4-0.8-0.40.30.4
Stereotopy head waving duration, day 70.40.51.2-1.10.9-0.40.7-0.80.80.70.7-1.0-0.7-0.7-0.70.7-0.7-0.60.6-0.7-0.6-0.5-0.40.30.1
Locomotion velocity, session 80.50.61.10.3-0.6-0.40.60.4-0.8-0.6-0.30.50.80.60.9-1.00.91.0-1.00.40.81.00.90.90.7
Locomotion distance, session 81.42.03.11.0-1.5-0.3-0.11.7-1.7-1.8-1.71.21.61.61.5-1.61.51.6-1.61.71.61.11.30.91.1
Degree of sensitization distance0.50.53.5-1.10.6-1.91.6-0.60.10.30.4-0.20.1-0.40.1-0.00.10.1-0.1-0.30.40.10.41.40.9
Degree of sensitization stereotypy0.20.30.9-1.00.7-0.80.8-0.20.40.20.2-0.7-0.4-0.2-0.40.4-0.4-0.40.4-0.2-0.3-0.3-0.00.60.5
Conditioned locomotion0.20.31.40.20.31.2-0.60.10.40.1-0.1-0.6-0.60.0-0.50.6-0.5-0.70.70.0-0.6-0.4-0.5-0.8-0.4
Cocaine response after cond. corrected0.40.41.90.80.21.4-0.1-0.80.10.60.80.40.30.50.3-0.40.30.3-0.3-0.8-0.91.20.7-0.7-0.6
Cocaine response after cond. not corrected0.40.42.10.70.11.10.50.1-0.3-0.2-0.00.40.61.20.6-0.70.60.5-0.50.1-0.41.41.30.10.4
Cocaine response before conditioning1.21.44.5-0.3-0.4-0.90.91.9-0.9-1.8-2.0-0.10.61.40.6-0.70.70.5-0.52.11.30.11.01.42.1
Saline control response0.91.23.91.4-2.00.2-1.91.5-1.2-1.2-1.31.30.80.30.8-0.70.80.8-0.81.11.5-0.4-0.3-0.5-0.7
Bone: connectivity density3.96.113.03.6-3.33.2-3.22.9-2.6-2.6-2.72.32.22.62.2-2.22.22.6-2.62.51.81.51.1-1.5-0.6
Bone: cortical apparent density0.30.42.6-0.70.5-1.61.4-0.40.00.10.3-0.10.20.00.2-0.20.20.2-0.2-0.20.10.50.51.20.8
Bone: cortical area3.04.66.92.0-2.10.4-0.12.4-2.4-2.4-2.42.42.52.62.4-2.52.42.3-2.32.42.02.12.31.01.3
Bone: cortical porosity0.00.00.20.2-0.20.2-0.40.0-0.00.0-0.00.1-0.1-0.2-0.00.0-0.0-0.10.10.0-0.0-0.1-0.3-0.3-0.3
Bone: cortical porosity0.10.10.5-0.50.3-0.70.20.00.20.0-0.2-0.4-0.4-0.3-0.30.3-0.3-0.40.40.20.0-0.5-0.30.20.3
Bone: cortical thickness2.43.95.72.0-2.10.2-0.22.1-2.3-2.1-2.12.42.32.32.3-2.42.32.1-2.12.11.82.02.10.91.0
Bone: cortical thickness1.21.42.61.1-1.6-0.7-0.51.5-1.4-1.4-1.41.61.21.01.3-1.31.21.2-1.21.41.50.60.80.50.4
Bone: cortical tissue density0.30.32.3-0.70.6-1.51.3-0.50.20.30.4-0.2-0.0-0.10.0-0.00.00.0-0.0-0.4-0.10.30.41.00.7
Condit. Reinf. active minus inactive responses0.20.31.5-0.90.9-0.71.2-0.20.40.20.2-0.5-0.30.2-0.20.2-0.2-0.10.1-0.1-0.40.20.40.80.8
Condit. Reinf. active-inactive response ratio0.30.31.3-0.40.4-0.51.20.2-0.2-0.2-0.30.10.30.70.4-0.40.40.4-0.40.40.00.80.91.01.1
Condit. Reinf. active responses0.20.31.1-1.00.7-0.91.00.20.3-0.1-0.2-0.7-0.40.1-0.30.3-0.3-0.20.20.3-0.0-0.30.20.81.0
Condit. Reinf. inactive responses0.50.62.1-1.40.8-1.30.8-0.00.70.1-0.0-1.2-0.9-0.6-0.80.8-0.8-0.70.70.00.1-1.2-0.60.60.7
Incentive salience index mean0.30.31.2-1.10.9-1.01.00.20.50.0-0.2-0.8-0.50.1-0.50.4-0.5-0.40.40.3-0.2-0.40.20.71.0
Condit. Reinf. lever presses0.30.41.0-1.00.5-1.00.60.60.3-0.4-0.6-0.8-0.40.2-0.50.5-0.5-0.50.50.70.0-0.70.00.51.0
Condit. Reinf. active minus inactive responses2.53.15.10.9-1.8-1.30.51.8-2.1-1.9-1.81.72.11.51.9-2.01.92.2-2.21.82.31.41.71.71.5
Condit. Reinf. active-inactive response ratio1.61.73.20.2-1.1-1.60.91.0-1.5-1.2-1.01.11.50.81.4-1.51.41.6-1.61.11.81.11.31.71.3
Condit. Reinf. active responses3.04.26.30.9-1.9-1.20.52.5-2.3-2.5-2.51.72.32.22.1-2.22.12.4-2.42.52.51.42.11.82.0
Condit. Reinf. inactive responses0.60.82.50.5-0.80.2-0.31.6-0.8-1.3-1.50.60.71.30.7-0.60.60.8-0.81.50.80.30.80.30.8
Condit. Reinf. lever presses0.70.92.70.2-0.6-0.30.11.6-0.9-1.3-1.60.30.91.40.6-0.70.61.0-1.01.60.90.40.90.71.3
Condit. Reinf. lever reinforcers received2.53.55.40.5-1.6-1.50.72.2-2.0-2.2-2.31.42.01.91.8-1.91.82.1-2.12.32.31.21.91.92.0
Conditioned reinforcement - actives3.03.06.81.5-2.6-0.2-1.52.1-2.3-1.8-1.92.32.01.41.7-1.92.01.9-1.91.72.10.90.80.1-0.1
Conditioned reinforcement - inactives0.30.31.40.0-0.51.2-1.1-0.20.00.20.30.2-0.3-0.7-0.30.2-0.1-0.40.4-0.4-0.0-0.6-0.7-1.0-1.1
Conditioned locomotion2.12.55.61.1-2.10.7-1.32.4-1.9-2.0-2.31.91.61.71.3-1.41.71.4-1.42.21.90.61.00.20.4
Patch foraging indifference point 0 sec0.91.54.40.20.41.3-1.8-0.41.10.80.6-0.7-1.4-0.8-1.31.6-1.3-1.21.2-0.7-1.2-1.5-1.5-2.1-1.7
Patch foraging indifference point AUC0.40.51.41.0-1.20.1-1.10.9-0.8-0.7-0.70.70.60.60.4-0.70.40.7-0.70.60.8-0.00.2-0.4-0.4
Delay disc. indifference point, 0s delay2.22.47.70.6-0.6-0.81.80.2-1.5-0.8-0.31.41.91.42.0-2.22.11.7-1.70.41.22.82.12.01.5
Delay disc. indifference point, 16s delay0.50.54.4-0.70.3-2.11.4-0.1-0.2-0.20.0-0.30.20.10.4-0.40.50.2-0.20.00.50.40.31.41.1
Delay disc. indifference point, 2s delay1.71.89.9-1.41.1-2.13.10.1-0.3-0.5-0.3-0.80.51.00.7-0.70.90.3-0.30.50.51.31.42.72.7
Delay disc. indifference point, 24s delay0.50.42.1-1.00.6-1.41.4-0.80.20.30.7-0.6-0.2-0.6-0.10.1-0.0-0.30.3-0.60.20.0-0.11.10.7
Delay disc. indifference point, 4s delay0.80.95.0-1.00.7-1.52.2-0.0-0.2-0.5-0.1-0.40.40.60.5-0.60.60.2-0.20.30.40.91.01.81.9
Delay disc. indifference point, 8s delay0.60.64.9-0.90.3-2.21.60.0-0.2-0.4-0.1-0.70.10.00.3-0.40.40.1-0.10.20.80.10.41.51.4
Indifference point function ln k0.20.31.2-0.40.1-0.7-0.5-0.00.40.20.0-0.4-0.6-0.8-0.50.7-0.5-0.70.7-0.1-0.0-1.1-0.9-0.4-0.4
Indifference point function log k0.20.31.2-0.40.1-0.7-0.5-0.00.40.20.0-0.4-0.6-0.8-0.50.7-0.5-0.70.7-0.1-0.0-1.1-0.9-0.4-0.4
Patch foraging total patch changes 0 sec1.32.15.5-0.00.51.3-2.0-0.41.31.00.6-1.1-1.7-1.1-1.61.9-1.6-1.51.5-0.7-1.3-1.9-1.9-2.3-1.9
Patch foraging total patch changes 12 sec0.30.41.80.8-0.11.1-1.20.10.20.10.1-0.0-0.40.2-0.40.4-0.5-0.30.3-0.1-0.5-0.4-0.4-1.4-1.0
Patch foraging total patch changes 18 sec1.21.55.00.40.11.7-2.1-0.40.90.80.7-0.6-1.2-0.8-1.31.3-1.3-0.90.9-0.8-1.0-1.4-1.6-2.2-2.0
Patch foraging total patch changes 24 sec1.01.34.8-0.50.30.3-1.40.40.90.1-0.2-1.2-1.5-0.8-1.51.5-1.5-1.41.40.2-0.4-2.2-1.6-1.4-0.7
Patch foraging total patch changes 6 sec0.60.93.90.6-0.11.5-1.90.20.50.30.0-0.5-0.9-0.3-0.90.9-1.0-0.70.7-0.2-0.6-1.2-1.1-2.0-1.4
Patch foraging time to switch 0 sec0.81.35.2-0.51.60.92.3-1.90.61.21.7-0.20.10.10.3-0.20.2-0.10.1-1.4-1.42.01.20.90.6
Patch foraging water rate 0 sec1.11.811.61.3-1.80.8-3.42.0-0.6-1.2-1.70.4-0.10.0-0.20.3-0.1-0.10.11.41.0-1.8-1.4-2.0-1.4
Patch foraging water rate 12 sec0.30.52.2-0.2-0.5-0.4-0.91.1-0.0-0.7-1.0-0.3-0.5-0.4-0.50.5-0.4-0.50.50.90.6-1.5-1.0-0.40.0
Patch foraging water rate 18 sec0.50.62.8-0.9-0.1-1.70.61.0-0.1-0.8-1.1-0.4-0.3-0.2-0.20.2-0.2-0.50.51.10.9-1.1-0.30.91.2
Patch foraging water rate 24 sec0.81.13.31.1-1.70.9-1.51.8-1.1-1.5-1.70.70.50.40.7-0.60.80.4-0.41.61.4-0.5-0.4-0.4-0.1
Patch foraging water rate 6 sec0.40.62.4-0.0-0.51.0-1.11.5-0.2-1.0-1.5-0.2-0.20.4-0.40.4-0.2-0.30.31.40.6-1.1-0.6-0.60.3
Seeking ratio, delayed vs. immediate footshock3.44.06.1-1.51.90.5-0.1-2.42.32.52.4-1.5-2.2-2.4-2.32.2-2.2-2.22.2-2.5-2.1-1.7-1.8-1.2-1.7
Distance traveled before self-admin0.40.41.8-0.90.6-0.81.30.10.1-0.2-0.2-0.8-0.1-0.00.10.20.30.1-0.10.20.40.2-0.21.31.3
Distance traveled after self-admin0.10.10.5-0.3-0.1-0.70.40.4-0.2-0.4-0.5-0.00.20.10.3-0.10.20.4-0.40.50.5-0.1-0.00.70.6
Extensor digitorum longus weight4.517.527.44.8-5.22.5-2.65.2-4.9-5.0-5.04.44.64.74.4-4.44.44.3-4.34.94.13.23.30.31.2
Bone: elastic displacement0.20.30.90.8-0.80.6-0.90.5-0.6-0.5-0.40.80.40.30.4-0.50.40.5-0.50.40.40.20.0-0.5-0.4
Bone: elastic work2.33.06.42.5-2.51.5-2.12.1-2.0-1.9-1.92.11.71.61.7-1.71.61.7-1.71.81.51.00.8-0.8-0.4
Bone: endosteal estimation0.40.84.41.4-1.21.6-2.10.8-0.6-0.5-0.70.70.30.20.2-0.20.20.3-0.30.50.4-0.3-0.6-1.5-1.1
Bone: endosteal perimeter0.61.23.51.1-1.30.8-1.11.9-1.2-1.5-1.80.80.91.20.8-0.80.80.8-0.81.81.20.10.4-0.20.4
Epididymis fat weight0.30.82.10.3-0.21.00.41.2-0.7-1.1-1.3-0.30.51.50.8-0.50.70.8-0.81.30.60.81.10.71.3
Delta time in closed arm before/after self-admin0.30.31.1-0.3-0.3-0.80.50.7-0.4-0.6-0.70.00.20.30.6-0.20.70.3-0.30.60.90.10.11.00.7
Delta time in open arm before/after self-admin1.71.63.5-1.51.9-0.81.0-1.41.51.21.3-1.6-1.3-1.1-1.51.3-1.7-1.31.3-1.1-1.7-0.9-0.6-0.00.2
Diff in mean of infusions in LGA sessions0.20.20.9-0.1-0.2-0.30.10.9-0.4-0.8-0.90.00.10.80.1-0.20.10.2-0.20.90.4-0.10.50.30.8
Delay discount exponential model param1.51.67.91.2-0.52.8-2.6-0.10.50.60.30.6-0.6-0.5-0.80.8-0.9-0.50.5-0.4-1.0-0.8-0.9-2.5-2.3
Extinction: sum of active levers before priming0.50.42.2-1.10.9-1.41.5-0.40.40.10.2-0.8-0.30.0-0.30.3-0.3-0.30.3-0.1-0.3-0.10.21.01.0
Active lever presses in extinction session 60.20.20.60.3-0.30.8-0.10.5-0.4-0.5-0.50.30.30.60.3-0.40.20.3-0.30.50.20.30.7-0.00.2
Bone: final force2.33.86.62.4-2.50.5-1.01.7-2.4-1.9-1.72.62.41.72.4-2.32.32.2-2.21.62.01.81.50.40.2
Bone: final moment1.83.05.62.2-2.30.6-1.01.5-2.1-1.6-1.42.42.11.52.1-2.12.02.0-2.01.31.71.61.30.2-0.0
Food consumed during 24 hour testing period0.30.41.70.5-0.30.7-1.3-0.20.20.40.30.3-0.3-0.6-0.60.3-0.5-0.40.4-0.4-0.5-0.6-0.7-1.3-1.1
Glucose0.20.31.7-0.60.6-0.61.3-0.70.10.40.60.00.2-0.00.1-0.20.10.4-0.4-0.5-0.20.70.60.90.5
Heart weight0.40.52.3-1.1-0.4-1.1-0.00.7-0.1-0.5-0.6-0.5-0.2-1.0-0.50.3-0.5-0.10.10.61.3-1.5-0.90.70.4
Delay discount hyperbolic model param1.41.57.31.2-0.62.7-2.60.00.40.50.10.7-0.5-0.4-0.70.7-0.8-0.40.4-0.3-0.8-0.9-0.8-2.4-2.2
Intermittent access intake day 1-15 change0.60.63.51.0-1.11.0-1.90.3-0.4-0.1-0.21.00.10.00.0-0.20.20.1-0.10.10.2-0.40.0-1.4-1.4
Intermittent access intake escalation0.50.52.50.9-1.20.5-1.60.8-0.6-0.5-0.61.00.30.30.2-0.40.40.3-0.30.50.6-0.30.2-1.0-0.9
Intermittent access intake escalation 20.20.20.8-0.1-0.10.2-0.90.00.20.2-0.00.2-0.5-0.4-0.50.4-0.3-0.60.6-0.0-0.1-0.8-0.2-0.8-0.7
Intermitt. access day 1 inactive lever presses0.90.92.80.1-0.21.4-1.4-0.50.50.50.5-0.5-0.9-1.6-0.80.7-0.7-0.90.9-0.7-0.3-1.3-1.7-1.3-1.4
Intermitt. access day 15 inactive lever presses0.91.06.50.30.62.5-0.7-1.30.81.21.2-0.1-0.7-0.5-0.70.5-0.3-0.60.6-1.2-1.50.3-0.1-1.4-1.3
Intermitt. access escalation Index0.40.32.0-0.80.4-1.40.20.50.3-0.2-0.6-0.5-0.40.0-0.60.6-0.6-0.20.20.60.3-0.7-0.00.40.7
Intermittent access day 1 total infusions0.70.84.3-1.90.9-2.11.50.00.40.0-0.1-0.6-0.5-0.3-0.60.5-0.6-0.50.50.20.0-0.60.11.21.2
Intermittent access day 15 total infusions0.10.10.7-0.9-0.1-0.6-0.20.50.1-0.2-0.40.1-0.3-0.1-0.50.3-0.3-0.40.40.40.1-0.8-0.0-0.10.1
Intermittent access terminal intake (last 3 days)0.20.21.1-1.00.5-0.80.2-0.20.50.30.2-0.1-0.5-0.3-0.70.5-0.6-0.60.6-0.2-0.4-0.7-0.0-0.00.0
Intermittent access total infusions0.40.42.4-1.50.6-1.41.20.10.30.0-0.1-0.2-0.20.1-0.50.2-0.4-0.30.30.2-0.1-0.30.40.90.9
Intermittent access day 1 locomotion1.21.25.9-2.41.5-1.42.10.10.80.0-0.3-1.1-0.80.0-0.90.8-0.9-0.90.90.4-0.3-0.70.41.51.8
Intermittent access day 15 total locomotion0.60.62.1-1.40.0-0.20.61.2-0.1-0.9-1.3-0.3-0.30.2-0.30.20.1-0.40.41.30.9-0.80.01.01.3
Intermittent access total locomotion1.01.15.7-2.41.0-1.21.80.60.4-0.4-0.7-0.8-0.60.0-0.80.6-0.5-0.80.80.80.3-0.90.41.61.9
Intermittent access standard deviation0.80.95.00.6-0.22.2-1.5-0.70.40.70.80.3-0.4-0.5-0.40.3-0.3-0.50.5-0.9-1.1-0.1-0.5-1.8-1.7
Left kidney weight6.618.536.75.9-6.14.1-3.74.7-5.1-4.6-4.34.84.64.04.6-4.54.54.6-4.64.04.43.22.5-0.6-0.3
Right kidney weight5.515.430.95.6-5.44.1-3.43.9-4.6-4.0-3.64.54.33.74.3-4.24.14.4-4.43.33.73.32.4-0.7-0.5
Cocaine induced anxiety0.30.41.8-0.90.6-0.21.00.70.1-0.5-0.8-0.9-0.20.7-0.10.2-0.1-0.30.30.80.1-0.10.60.81.3
Post-drug Anxiety1.21.47.8-2.11.9-1.22.8-0.70.90.60.5-1.6-0.6-0.0-0.40.5-0.4-0.50.5-0.3-0.60.20.61.91.8
Baseline Anxiety1.31.45.3-1.51.8-0.62.3-2.01.11.51.8-0.9-0.6-1.0-0.60.5-0.6-0.40.4-1.6-1.10.50.11.10.5
Tail length6.519.833.55.2-5.83.0-2.44.8-5.3-4.8-4.55.15.14.55.1-5.05.25.0-5.04.24.83.83.40.80.8
Length with tail12.445.377.68.7-8.85.2-4.66.9-7.9-7.0-6.58.07.76.87.6-7.57.67.5-7.56.26.56.05.0-0.00.3
Length without tail8.217.932.05.7-5.03.6-2.74.2-4.8-4.2-4.14.94.84.84.7-4.74.64.8-4.83.93.34.43.6-0.30.4
Times rat made contact with spout0.80.91.71.0-1.3-0.5-0.40.8-1.2-1.0-0.81.31.20.71.1-1.21.01.1-1.10.71.20.70.70.40.2
Lifetime Intake0.30.31.7-1.30.8-1.21.1-0.30.40.30.3-0.1-0.10.1-0.40.2-0.4-0.20.2-0.2-0.50.00.40.60.6
Liver weight, left0.81.26.51.5-0.82.4-2.50.10.10.20.10.3-0.2-0.2-0.30.3-0.4-0.20.2-0.3-0.5-0.5-1.0-2.3-2.0
Liver weight, right2.23.77.42.7-2.62.5-2.32.4-2.1-2.1-2.21.71.62.01.7-1.81.81.8-1.82.11.71.10.9-0.9-0.3
Locomotor activity2.13.48.01.3-2.4-1.0-0.42.5-2.2-2.5-2.41.61.71.52.0-1.82.01.9-1.92.32.80.61.01.21.1
Locomotor testing distance0.30.51.80.9-1.30.3-1.31.1-0.7-0.9-0.90.50.20.30.4-0.30.40.5-0.50.80.9-0.4-0.3-0.5-0.5
Locomotor testing rearing0.40.61.2-0.20.40.3-0.8-0.30.80.50.4-1.0-1.1-0.6-0.91.0-0.9-0.80.8-0.4-0.7-1.1-1.0-1.1-0.8
Locomotion in novel chamber0.20.20.8-0.2-0.50.2-0.90.7-0.1-0.3-0.60.2-0.2-0.4-0.30.3-0.0-0.20.20.50.4-0.9-0.7-0.1-0.3
Locomotion in novel chamber post-restriction1.72.04.71.3-2.10.2-0.82.0-1.8-2.0-1.91.01.41.01.4-1.51.71.3-1.31.82.20.20.50.40.5
Fecal boli incidents, locomotor time 11.11.22.61.0-1.40.5-0.71.6-1.3-1.5-1.50.41.20.91.1-1.01.11.2-1.21.41.50.40.00.30.5
Change in fecal boli incidents, locomotor task0.70.62.0-0.30.8-0.20.2-1.40.81.21.4-0.2-0.6-0.8-0.70.6-0.7-0.50.5-1.3-1.20.1-0.4-0.5-0.8
Time >=10cm from walls, locomotor time 10.60.63.1-1.31.2-1.01.8-0.20.40.1-0.0-1.0-0.10.5-0.00.0-0.1-0.20.20.2-0.40.70.31.31.5
Bouts of movement, locomotor time 10.91.02.11.1-1.4-0.3-1.11.3-1.2-1.1-1.21.11.01.01.1-1.00.90.9-0.91.21.10.40.8-0.00.0
Total resting periods, locomotor time 10.91.01.81.0-1.4-0.6-0.91.3-1.2-1.2-1.31.01.01.01.1-1.10.90.9-0.91.21.20.40.90.20.2
Rest time, locomotor task time 10.60.71.20.9-0.9-0.2-0.61.1-1.0-0.8-1.10.80.91.10.9-0.90.80.8-0.81.00.70.70.80.10.2
Distance moved, locomotor task time 10.20.20.6-0.80.4-0.70.7-0.40.30.10.3-0.5-0.2-0.6-0.30.3-0.3-0.20.2-0.30.1-0.4-0.40.50.4
Vertical activity count, locomotor time 10.20.21.40.1-0.5-1.20.00.3-0.4-0.5-0.30.10.2-0.10.3-0.20.30.2-0.20.30.8-0.4-0.10.40.2
Time >=10cm from walls, locomotor time 21.81.94.70.9-0.71.10.81.0-1.4-1.3-1.10.81.51.91.7-1.61.61.7-1.71.20.92.21.41.11.4
Bouts of movement, locomotor time 21.11.12.51.1-1.4-0.3-1.01.6-1.2-1.4-1.61.20.91.20.9-0.91.00.6-0.61.61.20.31.2-0.10.4
Total resting periods, locomotor time 20.90.91.91.2-1.3-0.2-1.11.4-1.1-1.2-1.41.20.81.20.8-0.80.80.5-0.51.30.90.31.2-0.30.1
Rest time, locomotor task time 20.10.10.4-0.60.5-0.70.10.20.30.1-0.3-0.2-0.30.3-0.30.3-0.4-0.20.20.3-0.4-0.20.60.10.4
Distance moved, locomotor task time 20.20.20.90.4-0.3-0.2-0.5-0.60.00.40.70.20.1-0.9-0.1-0.0-0.10.0-0.0-0.80.2-0.3-0.9-0.4-0.9
Vertical activity count, locomotor time 20.80.93.21.5-1.80.5-1.60.6-1.1-0.7-0.41.10.8-0.10.7-0.80.70.8-0.80.21.3-0.1-0.6-0.7-1.1
Light reinforcement 10.50.94.5-1.20.6-2.12.10.0-0.1-0.2-0.2-0.20.30.30.4-0.20.30.4-0.40.30.50.51.01.91.7
Light reinforcement 20.40.51.3-0.50.6-0.20.0-1.00.70.91.0-0.5-0.6-1.2-0.70.9-0.5-0.80.8-1.0-0.5-0.6-0.9-0.3-0.7
Bone: marrow area0.40.84.71.3-1.21.5-2.20.7-0.5-0.5-0.60.60.20.10.1-0.10.20.2-0.20.50.4-0.4-0.7-1.5-1.2
Bone: maximum diameter1.22.24.02.0-1.81.3-1.31.8-1.7-1.6-1.71.81.61.81.5-1.61.51.4-1.41.61.11.21.1-0.40.1
Bone: maximum force1.72.95.52.2-2.30.8-1.41.9-2.1-1.9-1.82.11.91.71.9-1.91.91.8-1.81.71.71.21.1-0.10.0
Bone: maximum moment1.32.24.42.0-2.10.9-1.41.6-1.8-1.6-1.51.91.61.41.6-1.61.61.5-1.51.41.41.00.9-0.3-0.2
Mean time between licks in bursts1.52.13.8-1.71.7-0.50.7-1.31.71.41.3-1.9-1.8-1.5-1.71.6-1.7-1.61.6-1.3-1.4-1.4-1.3-0.3-0.3
Mean num. licks in bursts0.50.61.9-0.20.0-0.10.81.1-0.4-0.9-1.10.00.41.30.5-0.50.40.6-0.61.20.30.51.10.81.4
Cd content in liver3.13.47.5-2.11.5-1.6-0.1-1.31.91.51.3-2.1-2.1-2.4-2.32.2-2.3-2.22.2-1.3-1.1-2.7-2.3-0.7-0.7
Co content in liver0.91.03.30.4-0.21.2-1.8-0.50.60.70.6-0.2-0.8-1.1-0.90.8-0.9-0.70.7-0.8-0.6-1.2-1.5-1.8-1.8
Cu content in liver0.40.51.3-0.40.50.5-0.60.10.70.3-0.1-0.8-0.8-0.3-1.10.9-1.1-0.80.80.1-0.6-1.1-0.8-0.8-0.3
Fe content in liver2.42.98.61.2-1.70.1-0.72.9-1.8-2.5-2.91.21.42.31.3-1.31.31.2-1.22.91.80.51.30.51.5
K content in liver0.10.10.50.2-0.10.50.10.5-0.3-0.4-0.50.00.20.70.2-0.30.20.4-0.40.50.10.40.50.10.4
Mg content in liver0.30.30.70.8-0.80.5-0.40.6-0.7-0.5-0.50.70.60.60.6-0.70.60.7-0.70.40.50.60.5-0.0-0.1
Mn content in liver0.91.02.4-0.70.90.0-0.1-1.51.11.41.5-0.8-1.0-1.2-1.01.0-1.0-0.70.7-1.5-1.2-0.6-0.9-0.7-1.0
Na content in liver0.50.61.00.5-0.5-0.10.40.7-0.8-0.8-0.70.70.81.00.8-0.90.80.9-0.90.80.70.91.00.70.8
Rb content in liver1.11.43.3-1.71.8-0.11.0-0.61.50.90.7-1.8-1.5-0.5-1.51.5-1.5-1.21.2-0.6-1.3-1.0-0.40.10.5
Se content in liver3.23.99.81.0-1.10.41.02.5-1.8-2.3-2.51.31.83.11.8-1.91.82.1-2.12.61.42.02.71.62.3
Sr content in liver1.21.14.10.6-0.11.5-1.7-1.00.61.01.10.0-0.5-1.2-0.60.6-0.6-0.70.7-1.3-0.9-0.7-1.3-1.8-2.0
Zn content in liver1.41.66.32.2-1.82.5-2.50.8-1.0-0.7-0.51.20.80.50.7-0.80.70.8-0.80.40.50.4-0.2-1.7-1.5
Bone: minimum diameter0.00.00.10.0-0.00.1-0.2-0.00.10.10.00.2-0.1-0.2-0.10.1-0.1-0.10.1-0.0-0.0-0.2-0.2-0.2-0.2
Time in familiar zone, hab. session 11.31.22.2-0.10.90.7-0.6-1.31.21.31.3-0.6-1.2-1.0-1.01.1-1.0-1.41.4-1.3-1.5-0.6-1.0-1.4-1.3
Time in novel zone, hab. session 11.01.01.80.5-1.0-0.10.31.0-1.1-1.1-1.00.91.10.91.0-1.21.01.3-1.31.01.10.90.90.90.8
Total zone transitions, hab. session 10.71.04.9-2.01.2-2.21.7-0.50.70.40.3-1.3-0.7-0.6-0.80.7-0.8-0.70.7-0.2-0.1-0.9-0.11.31.1
Total locomotion distance, hab. session 10.30.42.1-1.20.8-0.91.50.10.2-0.1-0.2-0.8-0.10.4-0.20.1-0.2-0.10.10.30.0-0.00.61.11.3
Locomotion velocity, hab. session 10.60.93.7-1.81.3-1.51.9-0.20.60.20.1-1.2-0.4-0.0-0.50.5-0.5-0.50.50.1-0.2-0.40.41.41.5
Time in familiar zone, hab. session 20.10.10.80.40.20.90.1-0.30.10.20.4-0.00.10.30.2-0.10.2-0.10.1-0.3-0.50.60.4-0.2-0.2
Time in novel zone, hab. session 20.20.21.9-1.00.3-1.40.50.00.20.0-0.1-0.3-0.3-0.5-0.40.3-0.4-0.20.20.20.2-0.7-0.40.60.5
Total zone transitions, hab. session 20.10.11.00.1-0.4-1.00.0-0.1-0.4-0.10.10.30.4-0.30.4-0.30.40.3-0.3-0.10.7-0.0-0.00.4-0.1
Total locomotion distance, hab. session 20.10.21.4-0.70.3-1.20.5-0.20.20.10.1-0.3-0.1-0.4-0.20.2-0.2-0.30.3-0.10.2-0.4-0.10.50.3
Locomotion velocity, hab. session 20.10.21.4-0.70.3-1.20.5-0.30.20.20.3-0.3-0.2-0.5-0.20.2-0.2-0.30.3-0.20.2-0.5-0.10.50.2
Novel to familiar place preference ratio0.10.10.6-0.3-0.0-0.70.3-0.5-0.00.30.4-0.00.2-0.60.0-0.10.00.3-0.3-0.40.3-0.0-0.20.4-0.1
Novelty place preference0.20.20.7-0.60.3-0.90.6-0.80.20.50.7-0.3-0.1-0.8-0.20.2-0.20.1-0.1-0.60.1-0.2-0.40.4-0.0
Time in novel zone, NPP test0.10.10.5-0.40.1-0.70.4-0.60.10.30.5-0.20.1-0.6-0.00.0-0.00.2-0.2-0.50.2-0.1-0.20.4-0.0
Total zone transitions, NPP test0.10.20.8-0.2-0.3-0.90.40.4-0.4-0.5-0.40.00.40.20.4-0.40.40.3-0.30.40.70.10.40.70.6
Total locomotion distance, NPP test0.60.93.2-0.6-0.0-1.01.31.0-0.6-1.0-1.1-0.10.71.00.6-0.60.60.5-0.51.20.90.51.21.51.8
Locomotion velocity, NPP test0.60.93.0-0.6-0.2-1.21.11.1-0.7-1.2-1.2-0.10.70.90.6-0.60.60.4-0.41.31.10.21.01.51.7
Intraocular pressure1.01.43.71.4-1.61.0-1.41.9-1.3-1.6-1.81.00.91.30.9-0.90.90.6-0.61.71.10.20.5-0.40.2
Delta distance traveled before/after self-admin0.10.10.80.3-0.5-0.4-0.9-0.0-0.00.10.10.50.0-0.4-0.1-0.0-0.2-0.10.1-0.1-0.0-0.5-0.3-0.6-0.8
Delta ambulatory time before/after self-admin0.20.20.5-0.30.2-0.4-0.4-0.40.50.50.4-0.1-0.4-0.6-0.50.4-0.7-0.50.5-0.4-0.5-0.7-0.3-0.5-0.6
Parametrial fat weight0.20.41.51.0-0.31.2-0.7-0.8-0.10.60.90.60.3-0.20.2-0.20.10.3-0.3-0.9-0.40.6-0.1-0.8-1.2
Pavlov. Cond. lever latency1.51.95.02.2-1.92.2-1.91.0-1.4-1.0-0.91.71.30.91.2-1.11.21.6-1.60.80.90.90.3-1.0-1.0
Pavlov. Cond. magazine entry latency0.40.51.50.3-0.7-1.20.10.8-0.8-0.8-0.80.50.50.60.7-0.80.70.3-0.30.80.90.40.60.70.6
Pavlov. Cond. change in total contacts0.60.73.1-0.60.4-1.21.80.1-0.3-0.4-0.20.00.50.80.5-0.70.50.2-0.20.40.30.91.31.51.4
Pavlov. Cond. index score0.30.31.8-0.50.2-1.31.00.4-0.2-0.5-0.5-0.20.10.50.3-0.40.3-0.10.10.50.30.20.70.91.1
Pavlov. Cond. latency score0.30.42.8-0.80.4-1.71.30.3-0.0-0.3-0.3-0.40.00.40.1-0.20.1-0.30.30.40.20.20.71.21.2
Pavlov. Cond. lever contacts0.91.03.0-1.71.5-1.61.7-0.71.00.60.6-1.3-0.9-0.5-0.80.7-0.8-1.11.1-0.4-0.7-0.5-0.00.91.0
Pavlov. Cond. magazine entry number0.81.02.5-0.40.91.1-0.2-1.61.11.41.5-0.7-0.8-1.2-0.91.0-0.9-0.60.6-1.5-1.2-0.4-0.9-0.9-1.1
Pavlov. Cond. intertrial magazine entries1.11.32.1-1.31.3-0.60.2-1.11.31.21.1-1.2-1.4-1.3-1.41.4-1.4-1.31.3-1.1-1.0-1.3-1.2-0.4-0.4
Pavlov. Cond. lever-magazine prob. diff.0.20.21.3-0.30.2-1.10.80.3-0.2-0.4-0.4-0.10.10.50.2-0.40.2-0.20.20.40.20.30.60.70.9
Pavlov. Cond. response bias0.40.41.1-0.0-0.3-1.00.50.9-0.6-0.9-0.90.10.40.80.5-0.60.50.2-0.21.00.70.30.70.81.0
Pavlov. Cond. lever latency1.11.44.50.70.21.4-1.5-1.30.91.31.4-0.1-1.0-1.2-0.70.8-0.7-1.11.1-1.5-1.3-0.5-1.3-1.9-2.1
Pavlov. Cond. magazine entry latency1.01.16.0-1.40.9-1.82.50.2-0.1-0.3-0.4-0.30.40.70.3-0.30.30.4-0.40.60.40.61.32.12.1
Pavlov. Cond. change in total contacts0.50.72.6-0.9-0.0-1.61.00.9-0.4-0.8-1.0-0.20.50.30.2-0.30.20.5-0.51.01.0-0.10.51.41.5
Pavlov. Cond. index score0.91.24.6-1.40.4-2.01.90.9-0.4-0.8-1.0-0.30.40.70.2-0.30.20.5-0.51.10.90.11.02.02.1
Pavlov. Cond. latency score0.81.04.4-1.30.5-1.81.90.8-0.3-0.7-0.9-0.30.40.70.2-0.30.20.4-0.41.00.70.21.11.92.1
Pavlov. Cond. lever contacts0.91.34.6-0.70.0-1.21.51.3-0.7-1.2-1.4-0.10.81.30.6-0.70.50.9-0.91.51.00.51.31.72.1
Pavlov. Cond. magazine entry number0.81.04.71.8-1.02.2-2.1-0.0-0.20.10.20.6-0.0-0.10.2-0.10.20.0-0.0-0.4-0.30.1-0.6-1.8-1.8
Pavlov. Cond. intertrial magazine entries0.20.31.00.8-1.00.4-1.00.6-0.6-0.5-0.50.60.30.10.4-0.40.40.4-0.40.40.7-0.1-0.1-0.4-0.4
Pavlov. Cond. lever-magazine prob. diff.0.91.25.0-1.50.5-2.22.00.8-0.3-0.7-0.9-0.40.40.60.2-0.30.20.4-0.41.00.90.11.02.12.2
Pavlov. Cond. response bias1.21.66.7-1.40.4-1.82.11.2-0.5-1.1-1.4-0.50.61.10.4-0.50.40.7-0.71.51.00.31.32.22.6
Time in closed arm before self-admin0.70.83.41.5-1.31.3-1.80.7-0.7-0.5-0.61.30.60.10.4-0.40.30.7-0.70.40.8-0.10.0-1.3-1.1
Time in closed arm after self-admin0.50.51.90.4-1.10.1-0.81.2-0.6-0.8-1.10.60.20.10.4-0.10.50.4-0.41.01.4-0.6-0.2-0.0-0.1
Time in open arm before self-admin0.30.31.5-0.1-0.4-1.20.40.5-0.5-0.4-0.50.10.40.30.6-0.50.80.3-0.30.40.70.40.10.80.5
Time in open arm after self-admin0.10.10.5-0.10.4-0.30.4-0.40.10.30.3-0.10.10.2-0.1-0.2-0.1-0.20.2-0.3-0.70.40.40.00.1
Bone: periosteal estimation1.22.54.52.1-2.11.2-1.51.9-1.9-1.8-1.91.91.71.61.6-1.71.61.6-1.61.81.51.01.0-0.30.1
Bone: periosteal perimeter1.52.45.80.9-1.40.1-0.12.4-1.7-2.1-2.41.21.52.01.4-1.41.41.4-1.42.41.70.91.40.91.5
Bone: post-yield work0.20.31.10.5-0.50.9-0.61.0-0.4-0.8-0.9-0.00.21.00.2-0.20.20.3-0.30.90.20.00.3-0.40.2
Progressive ratio test 1 active lever presses0.20.20.50.0-0.7-0.4-0.40.4-0.6-0.3-0.30.60.60.20.3-0.50.40.5-0.50.30.60.20.10.1-0.1
Progressive ratio test 1 breakpoint0.30.30.60.2-0.8-0.8-0.30.3-0.7-0.4-0.30.80.70.20.4-0.70.50.7-0.70.20.60.30.20.1-0.2
Progressive ratio test 1 inactive lever presses0.30.31.20.2-0.90.1-1.10.5-0.4-0.4-0.40.20.0-0.7-0.1-0.10.10.1-0.10.30.7-0.8-0.9-0.5-0.6
Progressive ratio test 2 active lever presses0.80.92.4-0.0-1.2-1.6-0.31.3-1.1-1.1-1.21.00.90.60.7-0.80.80.8-0.81.21.4-0.10.50.60.5
Progressive ratio test 2 breakpoint0.60.74.1-0.4-0.9-2.00.11.0-0.8-0.9-1.00.80.70.20.5-0.60.60.6-0.60.91.3-0.20.30.90.6
Progressive ratio test 2 inactive lever presses0.80.94.80.5-1.51.2-2.21.4-0.7-0.9-1.20.70.1-0.3-0.1-0.10.1-0.00.01.01.0-1.2-0.8-1.2-0.9
Incentive Sensitization - Responses0.40.44.7-0.80.0-2.20.30.5-0.0-0.3-0.5-0.2-0.2-0.0-0.30.2-0.2-0.10.10.50.6-0.80.00.50.6
Incentive Sensitization - Breakpoint0.40.44.9-0.80.0-2.20.30.6-0.0-0.4-0.6-0.1-0.20.0-0.30.3-0.2-0.10.10.50.6-0.90.00.60.6
Sum of active levers in priming session hrs 5-60.40.41.5-0.20.61.01.2-0.30.00.00.2-0.20.20.90.3-0.30.40.2-0.2-0.1-0.51.11.10.50.8
Progressive ratio1.01.11.8-1.01.20.70.3-1.41.31.21.3-0.9-1.3-1.2-0.91.2-0.8-1.21.2-1.3-1.1-0.7-0.9-0.4-0.6
Food seeking constrained by brief footshock2.73.35.4-0.81.60.9-0.9-1.62.11.91.6-1.5-2.3-1.6-2.02.1-2.1-2.32.3-1.7-2.1-1.9-1.6-1.9-1.7
Seeking ratio, punishment vs. effort0.20.31.11.0-0.70.3-1.00.7-0.4-0.4-0.60.40.40.50.2-0.30.10.3-0.30.50.1-0.0-0.1-0.7-0.4
Retroperitoneal fat weight0.41.57.6-0.81.50.72.8-0.20.1-0.00.0-0.70.51.60.7-0.50.40.6-0.60.3-0.72.02.21.72.2
Reaction time number correct0.30.53.30.4-0.70.3-1.80.6-0.0-0.2-0.50.3-0.2-0.3-0.50.4-0.50.0-0.00.30.2-1.1-0.9-1.2-1.0
Reaction time mean minus median3.85.011.90.0-0.9-1.62.52.3-2.0-2.6-2.50.92.22.52.2-2.02.22.0-2.02.72.31.92.73.23.5
Reaction time mean minus median AUC1.01.35.1-1.00.2-1.92.01.1-0.5-1.1-1.2-0.40.50.80.6-0.30.50.3-0.31.31.10.11.02.02.3
Reaction time num false alarms0.81.14.9-1.1-0.0-2.21.51.1-0.5-1.0-1.2-0.00.40.60.4-0.40.50.3-0.31.31.3-0.10.81.91.9
Reaction time num false alarms AUC0.70.93.2-0.9-0.1-1.51.11.3-0.5-1.1-1.4-0.20.30.80.4-0.30.50.2-0.21.41.2-0.20.71.51.8
Reaction time trials correct on left0.30.53.30.4-0.70.3-1.80.6-0.0-0.2-0.50.3-0.2-0.3-0.50.4-0.50.0-0.00.30.2-1.1-0.9-1.2-1.0
Reaction time trials on left0.30.43.00.4-0.70.3-1.70.7-0.1-0.2-0.50.3-0.2-0.2-0.50.3-0.40.0-0.00.40.3-1.1-0.8-1.1-0.9
Reaction time mean1.21.711.1-1.81.6-2.63.3-1.00.50.40.7-0.7-0.0-0.10.10.0-0.0-0.30.3-0.5-0.20.71.02.42.0
Reaction time mean AUC1.31.710.7-1.91.6-2.73.3-0.90.60.40.7-0.8-0.2-0.2-0.10.2-0.2-0.40.4-0.4-0.20.40.92.32.0
Median of all reaction times1.82.410.3-2.32.3-2.63.2-2.01.31.41.7-1.3-0.9-1.0-0.70.8-0.9-1.01.0-1.5-1.10.10.31.81.3
Reaction time omissions0.50.74.0-1.20.8-1.22.00.10.1-0.3-0.3-0.80.10.20.2-0.10.2-0.10.10.40.30.30.71.71.8
Reaction time false alarm rate0.91.24.7-0.90.1-1.51.91.0-0.6-1.1-1.1-0.20.50.90.7-0.60.80.3-0.31.31.10.41.22.02.2
Reaction time premature initiation rate0.40.51.5-0.1-0.3-1.01.00.5-0.6-0.7-0.60.20.60.40.9-0.70.80.5-0.50.60.80.60.61.21.1
Reaction time premature initiations0.20.30.60.1-0.5-0.70.20.7-0.6-0.7-0.70.30.40.30.5-0.50.50.4-0.40.70.80.10.20.60.6
Std. dev. reaction times1.52.17.7-0.80.2-1.72.80.9-0.8-1.2-1.00.21.11.31.2-1.01.10.8-0.81.31.11.21.92.62.7
Reaction time trials completed0.30.43.00.4-0.70.3-1.70.7-0.1-0.2-0.50.3-0.2-0.2-0.50.3-0.40.0-0.00.40.3-1.1-0.8-1.1-0.9
Reaction time trials AUC0.30.42.60.2-0.50.2-1.60.60.1-0.1-0.50.0-0.4-0.3-0.70.5-0.6-0.10.10.30.1-1.3-0.9-1.1-0.8
Run reversals in cocaine runway, females0.40.41.0-0.60.8-0.6-0.0-0.50.80.70.5-0.7-0.8-0.4-1.00.8-1.0-0.50.5-0.4-0.8-0.7-0.2-0.4-0.1
Run reversals in cocaine runway, males0.70.72.9-0.60.2-1.0-0.7-0.30.70.50.3-0.5-0.9-1.1-1.00.8-1.0-1.11.1-0.4-0.1-1.7-0.9-0.7-0.7
Latency to leave start box in cocaine runway0.20.20.8-0.10.0-0.50.9-0.5-0.20.20.50.40.4-0.10.5-0.50.50.5-0.5-0.40.20.70.30.80.2
Latency to leave start box in cocaine runway, F0.30.30.80.8-0.40.3-0.2-0.6-0.40.30.70.90.6-0.00.7-0.60.70.8-0.8-0.7-0.00.90.2-0.1-0.7
Latency to leave start box in cocaine runway, M0.60.52.0-1.40.6-1.21.10.30.3-0.2-0.4-1.0-0.6-0.4-0.50.5-0.5-0.40.40.50.4-1.0-0.31.01.2
Std. dev. time between licks in bursts0.30.31.2-0.0-0.5-0.5-0.01.1-0.5-0.9-1.10.10.10.50.3-0.20.30.2-0.21.00.8-0.30.10.40.7
Total sessions with >9 infusions0.20.20.5-0.3-0.1-0.70.50.3-0.4-0.3-0.30.40.50.50.2-0.40.30.4-0.40.30.30.40.70.50.5
Short access day 1 total inactive lever presses0.30.31.5-0.10.11.2-0.4-0.50.40.50.6-0.2-0.5-0.9-0.50.5-0.3-0.60.6-0.6-0.3-0.5-0.7-0.7-0.8
Short access day 10 total inactive lever presses1.21.312.21.6-1.23.5-2.20.4-0.5-0.3-0.20.70.10.10.2-0.40.30.1-0.10.1-0.1-0.0-0.5-1.9-1.6
Short access day 1 total infusions1.31.43.7-0.91.50.60.3-1.71.41.61.6-0.8-1.0-0.8-1.31.1-1.4-1.01.0-1.6-1.9-0.4-0.4-0.8-0.8
Short access day 10 total infusions0.60.62.5-1.51.1-1.60.9-0.60.80.70.5-0.8-0.7-0.2-0.90.8-0.9-0.70.7-0.5-0.9-0.4-0.20.20.3
Short access total infusions0.40.41.3-0.70.9-0.21.0-1.20.50.91.1-0.00.0-0.1-0.30.2-0.2-0.10.1-1.0-1.10.70.40.2-0.1
Short access day 1 locomotion0.70.84.0-1.71.0-2.02.0-0.40.40.20.2-0.5-0.2-0.3-0.30.2-0.1-0.40.4-0.10.1-0.10.41.71.4
Short access day 10 total locomotion0.70.82.0-1.21.11.40.3-0.51.00.60.4-1.1-1.2-0.6-1.11.1-1.1-1.11.1-0.4-1.0-0.8-0.5-0.4-0.0
Short access total locomotion0.50.52.6-1.51.2-0.21.6-0.60.60.50.5-0.7-0.4-0.2-0.50.5-0.3-0.50.5-0.4-0.70.10.40.90.9
One hour access (0.3 mA shock)0.70.94.0-1.3-0.0-2.0-0.60.20.40.2-0.2-0.3-0.8-1.0-1.10.9-0.9-0.90.90.00.2-1.9-1.4-0.4-0.5
Compulsive drug intake3.33.35.1-2.02.1-1.31.0-2.12.11.92.0-2.1-2.0-2.2-2.12.1-2.0-1.81.8-1.9-1.5-1.8-1.8-0.2-0.5
One hour access (shock baseline)1.21.44.10.2-1.4-1.1-0.62.0-1.3-1.6-1.91.11.01.10.8-0.91.00.9-0.91.91.6-0.00.60.40.7
Social response proportion6.26.710.92.3-3.0-0.80.02.4-3.1-2.7-2.43.03.12.23.3-3.33.23.0-3.02.33.12.42.31.81.3
Social responses2.02.55.71.3-2.0-0.6-0.72.4-1.9-2.2-2.31.51.51.41.6-1.51.51.4-1.42.32.20.50.90.70.9
Social time1.52.012.3-2.11.6-3.52.1-1.21.01.01.0-1.4-1.1-1.4-0.91.0-0.9-1.31.3-0.9-0.4-0.9-0.61.40.9
Soleus weight1.02.86.72.1-2.21.4-1.92.6-1.8-2.2-2.51.71.51.81.4-1.31.41.2-1.22.41.50.60.7-0.60.2
Bone: stiffness0.91.52.80.8-1.3-0.9-0.01.5-1.5-1.5-1.61.01.41.11.3-1.31.31.1-1.11.51.70.70.91.01.0
Tibialis anterior weight6.522.131.85.3-5.62.8-2.35.4-5.5-5.4-5.25.05.35.45.2-5.25.25.0-5.05.14.54.24.00.81.6
Time to tail flick, vehicle, before self-admin0.70.84.1-0.70.6-1.52.0-0.6-0.10.10.40.00.50.30.5-0.40.60.7-0.7-0.30.31.11.11.71.2
Time to tail flick, vehicle, after self-admin0.20.21.3-0.60.3-1.10.90.10.0-0.1-0.2-0.10.10.10.10.0-0.00.4-0.40.30.40.00.41.00.9
Time to tail flick, test, before self-admin0.60.61.81.0-1.1-0.0-0.90.6-0.9-0.5-0.51.30.90.60.7-0.90.60.9-0.90.50.50.50.8-0.3-0.5
Time to tail flick, test, after self-admin0.40.41.40.5-0.20.10.40.1-0.5-0.2-0.20.70.70.90.9-0.70.80.8-0.80.20.11.21.20.40.3
Delta time to tail flick, vehicle, before/after SA0.40.41.3-0.60.60.1-0.3-0.10.80.40.1-0.6-0.8-0.6-0.90.9-1.1-0.70.7-0.1-0.5-1.1-0.6-0.5-0.2
Delta time to tail flick, test, before/after SA0.20.20.5-0.30.70.50.5-0.30.50.30.3-0.7-0.40.1-0.20.5-0.1-0.50.5-0.3-0.60.2-0.0-0.00.2
Tibia length2.87.919.14.4-3.82.6-2.41.7-3.2-2.0-1.44.33.32.33.4-3.43.43.1-3.11.32.03.21.9-0.6-1.2
Ambulatory time before self-admin0.80.84.0-0.70.3-1.11.60.9-0.3-0.9-1.0-0.60.30.80.5-0.20.60.4-0.41.10.90.40.51.72.0
Ambulatory time after self-admin0.20.21.0-0.40.1-0.80.70.5-0.2-0.6-0.6-0.10.30.40.3-0.10.20.4-0.40.60.40.10.30.91.0
Bone: tissue strength1.31.23.00.10.51.1-1.3-1.01.01.21.2-0.7-1.0-1.1-1.01.0-1.1-1.01.0-1.2-1.3-0.9-1.3-1.7-1.7
Total heroin consumption1.41.76.1-2.51.7-1.92.5-0.20.90.1-0.1-1.8-1.0-0.2-1.00.8-1.0-1.01.00.3-0.4-0.70.31.82.1
Bone: trabecular number2.54.09.03.0-2.62.7-2.52.3-2.1-2.0-2.11.91.82.21.8-1.81.82.1-2.12.01.31.40.9-1.2-0.5
Bone: trabecular spacing2.33.05.4-2.32.3-1.41.5-1.92.01.81.7-1.8-1.9-1.8-1.81.8-1.9-2.02.0-1.6-1.6-1.4-1.10.20.0
Bone: trabecular thickness3.84.57.82.8-2.52.4-2.02.8-2.2-2.5-2.62.01.92.71.9-1.91.92.2-2.22.51.51.51.5-0.70.2
Bone: trabecular tissue density3.14.411.2-0.2-0.7-2.72.71.6-1.9-1.9-1.81.32.01.92.1-2.12.11.8-1.82.02.12.02.63.33.1
Water consumed over 24 hours1.01.14.11.9-1.90.5-2.00.8-1.2-0.8-0.71.51.00.20.8-1.00.80.9-0.90.60.90.2-0.2-1.0-1.0
Number of responses in last shaping day0.10.10.4-0.40.00.0-0.3-0.00.10.20.1-0.1-0.2-0.2-0.40.3-0.5-0.30.3-0.1-0.0-0.6-0.2-0.4-0.4