Hub : Genes

Pitpnm1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Pitpnm1	0.28	0.11	3.6e-11	0.06	0.09	0.08	0.07	2.1e-07	5.3e-10	4.3e-09	2.1e-08
2	Adipose	isoform ratio	NM_001008369.1	0.02	0.02	5.8e-03	0.01	0.01	0.01	0.01	8.3e-03	8.7e-03	1.6e-02	1.1e-02
3	pVTA	gene expression	Pitpnm1	0.05	0.04	1.7e-04	0.05	0.04	0.04	0.04	6.6e-05	2.6e-04	3.3e-04	2.1e-04
4	Liver	gene expression	Pitpnm1	0.27	0.13	0.0e+00	0.17	0.18	0.17	0.17	1.2e-18	1.2e-19	5.3e-19	1.0e-18
5	PL	gene expression	Pitpnm1	0.03	0.03	1.2e-03	0.01	0.03	0.03	0.03	8.1e-03	3.5e-04	4.3e-04	6.0e-04
6	IL	gene expression	Pitpnm1	0.17	0.12	7.4e-03	0.01	-0	0.02	0.01	1.5e-01	3.8e-01	1.1e-01	2.0e-01
7	Brain	gene expression	Pitpnm1	0.18	0.12	1.1e-10	0.11	0.12	0.13	0.12	9.2e-11	7.4e-11	7.6e-12	9.8e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	1.8	3.1	5.5	0.5	1.3	1.3	-1.6	2.2	2.2	2.4
Area under the delay curve	0.8	0.9	1.5	0.7	0.8	0.8	-1.1	1.2	1.0	1.0
BMI with tail	0.7	2.6	9.4	-0.7	0.7	0.7	-1.1	2.1	1.2	3.1
BMI without tail	0.2	0.8	2.4	-1.5	-0.3	-0.3	0.1	0.7	0.0	1.5
Body weight	0.6	2.7	8.8	-3.0	-1.8	-1.8	1.3	-0.0	-0.5	1.2
Weight adjusted by age	0.5	0.7	1.5	-1.2	-1.1	-1.0	0.9	-0.6	-0.5	-0.1
Bone surface	0.9	1.6	5.0	-0.7	0.3	0.3	-0.9	1.8	1.3	2.2
Bone volume	1.1	1.9	3.9	0.2	0.9	0.9	-1.3	1.9	1.7	2.0
Breakpoint value in progressive ratio session	0.6	0.7	2.3	-1.5	-1.0	-0.9	0.8	-0.2	-0.2	0.5
Number of licking bursts	0.1	0.1	0.3	0.3	-0.0	0.0	-0.3	0.3	0.6	0.1
Context. condit. distance diff. score	0.7	0.8	1.6	1.3	0.9	1.0	-1.0	0.7	0.8	0.4
Locomotion velocity, session 1	0.0	0.0	0.0	0.1	-0.1	0.0	-0.0	0.1	0.2	0.2
Locomotion distance, session 1	0.8	1.0	2.3	0.2	0.5	0.6	-0.9	1.3	1.1	1.5
Locomotion velocity, session 2	0.8	0.9	2.4	-1.6	-1.1	-1.1	1.0	-0.5	-0.6	0.1
Locomotion distance, session 2	0.2	0.2	0.8	-0.6	-0.2	-0.2	-0.1	0.5	0.3	0.9
Locomotion velocity, session 3	1.5	1.7	2.8	0.9	1.0	1.1	-1.3	1.6	1.4	1.7
Locomotion distance, session 3	0.1	0.2	0.5	0.3	0.2	0.3	-0.4	0.4	0.4	0.7
Stereotopy head waving bouts, day 3	1.6	1.9	2.4	1.1	1.5	1.4	-1.5	1.5	1.3	1.4
Stereotopy head waving duration, day 3	1.4	1.7	2.2	1.4	1.5	1.4	-1.4	1.2	1.2	0.8
Locomotion velocity, session 7	0.9	1.0	1.8	0.5	0.9	0.9	-1.0	1.2	0.8	1.4
Locomotion distance, session 7	0.1	0.1	0.3	-0.5	-0.0	-0.0	-0.0	0.3	-0.0	0.6
Stereotopy head waving bouts, day 7	1.6	1.8	2.3	1.0	1.5	1.4	-1.5	1.5	1.2	1.3
Stereotopy head waving duration, day 7	0.7	0.8	1.7	0.1	0.7	0.7	-0.9	1.3	0.9	1.3
Locomotion velocity, session 8	0.5	0.6	1.5	-1.2	-1.0	-0.9	0.7	-0.3	-0.3	-0.1
Locomotion distance, session 8	0.4	0.6	0.7	0.8	0.7	0.8	-0.8	0.8	0.8	0.7
Degree of sensitization distance	0.1	0.1	0.3	-0.4	0.2	0.1	-0.2	0.4	0.1	0.6
Degree of sensitization stereotypy	0.3	0.3	0.6	0.1	0.5	0.5	-0.6	0.8	0.6	0.7
Conditioned locomotion	3.9	4.5	5.7	-2.2	-2.4	-2.4	2.3	-2.1	-1.7	-1.5
Cocaine response after cond. corrected	0.1	0.2	0.3	0.4	0.5	0.5	-0.4	0.3	0.2	0.3
Cocaine response after cond. not corrected	0.4	0.5	0.8	0.6	0.9	0.8	-0.7	0.7	0.5	0.6
Cocaine response before conditioning	0.0	0.0	0.1	0.1	0.2	0.1	-0.2	0.3	0.3	0.1
Saline control response	0.9	1.2	3.2	-1.8	-1.3	-1.4	1.1	-0.4	-0.5	-0.2
Bone: connectivity density	1.2	1.9	5.3	-0.5	0.5	0.5	-1.0	1.9	1.7	2.3
Bone: cortical apparent density	0.6	0.8	1.0	-0.9	-1.0	-1.0	1.0	-0.9	-0.9	-0.5
Bone: cortical area	0.9	1.4	1.7	-1.1	-1.3	-1.3	1.2	-1.1	-1.0	-1.2
Bone: cortical porosity	0.0	0.0	0.0	0.0	0.1	0.1	-0.1	0.2	-0.2	-0.1
Bone: cortical porosity	0.1	0.1	0.2	-0.5	-0.4	-0.4	0.3	-0.1	-0.4	-0.2
Bone: cortical thickness	5.9	9.7	12.0	-3.4	-3.4	-3.5	3.3	-2.8	-2.9	-2.4
Bone: cortical thickness	1.9	2.2	3.2	-1.8	-1.7	-1.7	1.6	-1.2	-1.2	-1.0
Bone: cortical tissue density	0.7	1.0	1.3	-1.1	-1.1	-1.1	1.1	-1.0	-1.0	-0.5
Condit. Reinf. active minus inactive responses	0.2	0.3	0.8	0.1	0.4	0.4	-0.5	0.7	0.4	0.9
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	0.4	0.5	0.5	-0.6	0.6	0.5	0.7
Condit. Reinf. active responses	0.0	0.1	0.2	0.1	0.2	0.2	-0.2	0.3	0.1	0.4
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.2	0.1	0.1	0.0	-0.2	-0.2	-0.2
Incentive salience index mean	0.1	0.1	0.5	0.0	0.2	0.2	-0.3	0.5	0.3	0.7
Condit. Reinf. lever presses	0.0	0.1	0.1	-0.2	-0.3	-0.3	0.2	-0.2	-0.2	-0.2
Condit. Reinf. active minus inactive responses	1.7	2.2	2.5	1.3	1.6	1.6	-1.6	1.5	1.2	1.5
Condit. Reinf. active-inactive response ratio	1.9	2.2	3.2	1.8	1.7	1.7	-1.6	1.3	1.2	1.0
Condit. Reinf. active responses	1.5	2.0	3.1	0.9	1.4	1.4	-1.5	1.7	1.3	1.8
Condit. Reinf. inactive responses	0.3	0.3	1.2	-0.5	0.1	0.1	-0.3	0.8	0.5	1.1
Condit. Reinf. lever presses	0.4	0.5	1.4	-0.2	0.4	0.3	-0.6	1.0	0.8	1.2
Condit. Reinf. lever reinforcers received	1.3	1.9	3.4	0.7	1.2	1.2	-1.4	1.7	1.3	1.8
Conditioned reinforcement - actives	0.3	0.5	1.2	-0.1	-0.4	-0.6	0.6	-0.9	-1.1	-0.9
Conditioned reinforcement - inactives	1.4	2.1	4.3	2.1	1.9	1.7	-1.5	0.9	0.8	0.5
Conditioned locomotion	2.0	2.6	8.7	3.0	1.9	1.8	-1.4	0.2	0.5	-0.6
Patch foraging indifference point 0 sec	0.2	0.3	0.9	0.7	0.8	1.0	-0.5	0.4	0.1	0.0
Patch foraging indifference point AUC	1.1	1.6	2.6	-1.3	-1.6	-1.6	1.4	-1.2	-1.0	-0.6
Delay disc. indifference point, 0s delay	1.7	1.9	2.7	1.0	1.2	1.3	-1.5	1.6	1.3	1.5
Delay disc. indifference point, 16s delay	0.8	0.9	2.0	1.4	1.1	0.9	-1.1	0.8	0.8	0.2
Delay disc. indifference point, 2s delay	1.0	1.1	1.4	1.1	1.1	1.2	-1.2	1.1	1.0	0.8
Delay disc. indifference point, 24s delay	0.3	0.3	0.4	-0.5	-0.6	-0.6	0.6	-0.6	-0.5	-0.7
Delay disc. indifference point, 4s delay	0.4	0.4	0.9	0.2	0.4	0.4	-0.7	0.8	0.7	0.9
Delay disc. indifference point, 8s delay	0.2	0.3	0.5	0.3	0.4	0.4	-0.5	0.7	0.5	0.6
Indifference point function ln k	1.1	2.0	4.2	2.0	1.9	1.8	-1.3	0.6	0.6	-0.3
Indifference point function log k	1.1	2.0	4.2	2.0	1.9	1.8	-1.3	0.6	0.6	-0.3
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	0.1	0.1	0.3	0.1	-0.3	-0.4	-0.5
Patch foraging total patch changes 12 sec	1.1	1.4	3.2	-1.8	-1.5	-1.4	1.1	-0.6	-0.7	0.1
Patch foraging total patch changes 18 sec	0.0	0.1	0.2	-0.2	-0.4	-0.2	0.1	0.1	0.0	0.2
Patch foraging total patch changes 24 sec	0.6	1.0	1.7	-1.2	-1.3	-1.1	1.1	-0.9	-0.7	-0.3
Patch foraging total patch changes 6 sec	0.1	0.2	0.6	-0.6	-0.3	0.1	-0.0	0.4	0.2	0.8
Patch foraging time to switch 0 sec	0.6	1.3	2.9	-0.0	0.4	0.4	-1.0	1.7	1.4	1.7
Patch foraging water rate 0 sec	0.7	1.5	4.8	0.9	0.1	0.0	0.7	-1.7	-1.2	-2.2
Patch foraging water rate 12 sec	0.7	1.5	4.5	1.5	0.4	0.3	0.3	-1.5	-0.9	-2.1
Patch foraging water rate 18 sec	0.2	0.3	0.8	0.8	0.6	0.4	-0.1	-0.4	-0.1	-0.9
Patch foraging water rate 24 sec	0.8	1.1	3.6	0.3	-0.2	-0.1	0.7	-1.5	-1.2	-1.9
Patch foraging water rate 6 sec	0.8	1.2	3.3	0.2	-0.4	-0.7	0.9	-1.5	-1.0	-1.8
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	1.4	0.6	1.0	0.8	-1.0	1.2	1.1	1.0
Distance traveled before self-admin	0.1	0.2	0.5	0.2	0.3	0.1	-0.6	0.7	0.2	0.6
Distance traveled after self-admin	0.0	0.0	0.2	0.0	0.0	-0.1	-0.1	0.1	-0.5	-0.3
Extensor digitorum longus weight	3.9	15.3	30.4	-5.5	-4.5	-4.6	4.0	-2.5	-3.5	-1.1
Bone: elastic displacement	2.6	3.0	4.3	-1.1	-1.5	-1.5	1.7	-2.1	-2.1	-2.0
Bone: elastic work	2.9	3.8	4.6	-2.1	-2.1	-2.1	2.0	-1.8	-1.9	-1.4
Bone: endosteal estimation	2.0	4.4	5.4	2.3	2.2	2.3	-2.3	2.0	2.0	1.5
Bone: endosteal perimeter	4.2	8.9	11.1	3.3	3.3	3.3	-3.3	2.8	2.5	2.1
Epididymis fat weight	1.6	5.3	14.2	3.8	2.8	2.8	-2.2	1.0	1.4	-0.5
Delta time in closed arm before/after self-admin	1.3	1.2	1.9	-1.4	-1.4	-1.3	1.1	-0.9	-0.8	-0.4
Delta time in open arm before/after self-admin	0.5	0.5	0.6	0.4	0.7	0.8	-0.6	0.7	0.7	0.7
Diff in mean of infusions in LGA sessions	0.4	0.5	1.1	-1.0	-0.9	-0.8	0.8	-0.5	-0.2	-0.4
Delay discount exponential model param	0.5	0.6	1.0	-0.5	-0.6	-0.6	0.8	-1.0	-0.8	-0.9
Extinction: sum of active levers before priming	0.4	0.5	1.0	-1.0	-0.5	-0.5	0.2	0.5	0.7	1.0
Active lever presses in extinction session 6	1.1	1.1	2.1	-1.4	-1.1	-1.0	1.0	-0.8	-1.4	-0.3
Bone: final force	0.2	0.4	1.2	-1.1	-0.8	-0.8	0.5	0.0	0.0	0.3
Bone: final moment	0.3	0.4	1.2	-1.1	-0.8	-0.8	0.5	-0.0	-0.0	0.2
Food consumed during 24 hour testing period	0.1	0.1	0.7	0.4	-0.1	-0.1	0.2	-0.4	-0.0	-0.8
Glucose	3.9	6.1	7.2	2.6	2.6	2.7	-2.7	2.4	2.2	2.0
Heart weight	1.9	2.9	3.7	1.5	1.7	1.7	-1.8	1.9	1.7	1.5
Delay discount hyperbolic model param	0.7	0.8	1.2	-0.6	-0.7	-0.7	1.0	-1.1	-0.9	-1.0
Intermittent access intake day 1-15 change	0.6	1.2	4.1	2.0	1.1	1.1	-0.9	0.2	0.5	-0.8
Intermittent access intake escalation	0.5	0.9	3.2	1.8	0.9	0.9	-0.8	0.1	0.3	-0.9
Intermittent access intake escalation 2	0.8	0.9	3.0	1.7	0.9	0.9	-0.8	0.2	0.7	-0.5
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.1	0.3	0.1	-0.0	-0.0	-0.4	0.0
Intermitt. access day 15 inactive lever presses	1.3	2.8	4.2	2.0	2.0	2.0	-1.8	1.5	1.2	0.7
Intermitt. access escalation Index	0.4	0.6	1.6	1.3	0.6	0.7	-0.3	-0.4	-0.4	-1.2
Intermittent access day 1 total infusions	4.4	7.1	8.8	2.5	3.0	2.9	-2.8	2.7	2.4	2.3
Intermittent access day 15 total infusions	3.9	5.7	11.1	3.3	2.9	2.8	-2.5	1.7	1.8	0.7
Intermittent access terminal intake (last 3 days)	5.0	6.6	10.4	3.2	3.0	2.9	-2.7	2.1	2.0	1.3
Intermittent access total infusions	4.2	4.9	6.8	2.6	2.6	2.5	-2.4	2.0	1.8	1.5
Intermittent access day 1 locomotion	2.3	2.9	4.1	1.6	2.0	2.0	-1.8	1.7	0.9	1.6
Intermittent access day 15 total locomotion	2.8	5.2	10.1	3.2	2.7	2.6	-2.4	1.7	1.6	0.7
Intermittent access total locomotion	6.7	8.0	14.1	3.8	3.4	3.3	-3.1	2.3	1.9	1.2
Intermittent access standard deviation	0.4	0.9	2.0	1.4	1.0	1.0	-1.0	0.7	1.0	0.2
Left kidney weight	0.5	2.1	5.6	2.4	1.6	1.6	-1.5	0.8	1.1	-0.0
Right kidney weight	0.2	0.7	2.2	1.5	0.8	0.8	-0.6	-0.1	0.3	-1.0
Cocaine induced anxiety	0.1	0.1	0.2	0.3	0.4	0.2	-0.4	0.4	0.2	0.2
Post-drug Anxiety	0.1	0.1	0.3	-0.6	-0.2	-0.4	0.2	0.1	0.0	0.2
Baseline Anxiety	0.3	0.4	0.8	-0.9	-0.7	-0.7	0.7	-0.5	-0.2	-0.2
Tail length	1.1	4.5	6.2	-2.5	-2.3	-2.3	2.3	-2.0	-1.8	-1.5
Length with tail	1.9	8.1	13.4	-3.7	-3.4	-3.4	3.1	-2.2	-2.0	-1.4
Length without tail	1.5	4.7	7.9	-2.8	-2.7	-2.7	2.3	-1.6	-1.4	-0.9
Times rat made contact with spout	0.2	0.2	0.4	-0.3	0.1	0.1	-0.3	0.6	0.6	0.6
Lifetime Intake	2.5	3.0	4.2	2.0	2.1	1.9	-1.9	1.6	1.3	1.3
Liver weight, left	0.2	0.3	1.1	0.3	-0.1	-0.1	0.3	-0.7	-0.4	-1.1
Liver weight, right	0.2	0.3	0.9	1.0	0.4	0.4	-0.2	-0.3	0.0	-0.9
Locomotor activity	0.1	0.2	0.8	0.5	0.2	0.2	0.0	-0.5	-0.2	-0.9
Locomotor testing distance	0.1	0.2	0.9	0.6	0.3	0.3	-0.0	-0.4	-0.1	-0.9
Locomotor testing rearing	0.5	0.9	1.4	1.1	1.2	1.0	-1.1	0.8	0.8	0.5
Locomotion in novel chamber	3.9	5.0	9.6	3.1	2.7	2.7	-2.2	1.4	1.9	0.5
Locomotion in novel chamber post-restriction	1.4	2.3	5.0	2.2	2.0	1.9	-1.4	0.8	1.0	0.1
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	0.1	0.4	0.3	-0.1	0.1	-0.2	-0.2
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.1	-0.2	0.0	-0.0	0.2	0.1	0.3
Time >=10cm from walls, locomotor time 1	3.9	4.1	5.8	2.1	2.2	2.4	-2.2	2.0	1.5	1.8
Bouts of movement, locomotor time 1	1.8	2.1	3.4	-1.3	-1.9	-1.8	1.5	-1.3	-1.0	-1.0
Total resting periods, locomotor time 1	1.2	1.3	2.1	-0.9	-1.5	-1.4	1.2	-1.2	-0.8	-1.0
Rest time, locomotor task time 1	0.3	0.4	1.1	1.0	0.2	0.3	-0.1	-0.5	-0.1	-1.1
Distance moved, locomotor task time 1	0.7	1.0	1.6	0.4	1.0	0.7	-1.0	1.3	1.0	1.2
Vertical activity count, locomotor time 1	0.6	1.4	2.4	1.3	1.5	1.3	-1.3	1.1	1.0	0.6
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.1	0.2	-0.1	0.2	0.2	-0.4	-0.3	-0.2
Bouts of movement, locomotor time 2	0.2	0.4	0.7	-0.8	-0.7	-0.5	0.6	-0.4	-0.7	-0.0
Total resting periods, locomotor time 2	0.0	0.1	0.1	-0.3	-0.4	-0.2	0.2	-0.1	-0.4	0.1
Rest time, locomotor task time 2	1.8	2.3	4.1	2.0	1.7	1.8	-1.7	1.3	1.2	0.6
Distance moved, locomotor task time 2	1.3	1.6	2.3	-1.5	-1.3	-1.4	1.4	-1.2	-1.0	-0.8
Vertical activity count, locomotor time 2	1.9	2.6	3.6	-1.4	-1.4	-1.5	1.7	-1.9	-1.6	-1.7
Light reinforcement 1	0.1	0.2	0.7	0.8	0.3	0.5	-0.2	-0.2	0.1	-0.5
Light reinforcement 2	0.4	0.6	1.9	1.4	0.8	0.9	-0.5	-0.1	0.2	-0.5
Bone: marrow area	2.1	4.6	5.6	2.4	2.3	2.4	-2.3	2.0	2.0	1.5
Bone: maximum diameter	0.0	0.1	0.4	0.3	0.1	0.1	-0.0	-0.1	-0.1	-0.6
Bone: maximum force	0.5	0.9	2.6	-0.5	0.2	0.2	-0.6	1.3	0.9	1.6
Bone: maximum moment	0.4	0.7	2.2	-0.6	0.1	0.1	-0.5	1.2	0.8	1.5
Mean time between licks in bursts	0.1	0.3	0.6	-0.8	-0.7	-0.7	0.6	-0.3	-0.3	0.0
Mean num. licks in bursts	0.1	0.1	0.2	-0.2	0.3	0.3	-0.2	0.3	-0.0	0.5
Cd content in liver	0.9	1.1	2.4	1.5	1.2	1.3	-1.0	0.6	0.6	0.2
Co content in liver	1.0	1.2	2.1	-0.3	-0.9	-0.8	1.1	-1.5	-1.1	-1.4
Cu content in liver	0.0	0.0	0.0	0.1	0.0	0.1	-0.0	-0.0	-0.0	0.2
Fe content in liver	0.1	0.1	0.3	-0.5	-0.5	-0.5	0.3	-0.2	-0.2	0.1
K content in liver	0.1	0.1	0.4	-0.3	-0.0	-0.1	-0.2	0.5	0.3	0.7
Mg content in liver	0.7	0.7	0.9	0.9	0.9	0.9	-0.9	0.8	0.8	0.6
Mn content in liver	0.7	0.8	2.2	-1.5	-1.1	-1.0	0.9	-0.4	-0.6	0.2
Na content in liver	0.6	0.7	1.1	-0.4	-0.8	-0.9	0.8	-1.0	-0.7	-1.1
Rb content in liver	2.0	2.3	3.0	1.6	1.6	1.7	-1.6	1.5	1.4	1.1
Se content in liver	0.7	0.8	0.9	0.9	0.9	0.9	-1.0	0.9	0.8	0.8
Sr content in liver	2.5	2.1	2.8	-1.7	-1.6	-1.6	1.6	-1.3	-1.3	-0.9
Zn content in liver	0.6	0.6	0.8	-0.9	-0.9	-0.8	0.9	-0.8	-0.7	-0.6
Bone: minimum diameter	2.2	4.1	5.2	2.0	2.2	2.2	-2.3	2.2	1.6	1.6
Time in familiar zone, hab. session 1	0.7	0.6	0.8	0.9	0.8	0.9	-0.9	0.7	0.6	0.7
Time in novel zone, hab. session 1	0.1	0.1	0.3	-0.3	-0.2	-0.3	0.4	-0.3	-0.2	-0.5
Total zone transitions, hab. session 1	0.1	0.1	0.2	-0.5	-0.3	-0.3	0.2	0.1	0.1	0.1
Total locomotion distance, hab. session 1	0.4	0.5	0.9	1.0	0.8	0.8	-0.8	0.6	0.6	0.2
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.5	0.4	0.4	-0.4	0.3	0.3	0.1
Time in familiar zone, hab. session 2	1.1	1.1	1.6	-1.1	-1.2	-1.2	1.2	-1.0	-0.9	-0.8
Time in novel zone, hab. session 2	1.2	1.2	1.6	0.8	1.2	1.1	-1.2	1.3	1.0	1.1
Total zone transitions, hab. session 2	1.7	2.2	5.4	0.1	1.0	1.0	-1.4	2.0	1.5	2.3
Total locomotion distance, hab. session 2	1.2	1.6	2.3	0.8	1.2	1.1	-1.3	1.5	1.2	1.4
Locomotion velocity, hab. session 2	1.4	1.9	2.4	1.0	1.4	1.3	-1.5	1.6	1.3	1.4
Novel to familiar place preference ratio	0.3	0.3	0.5	0.2	0.4	0.4	-0.5	0.7	0.7	0.5
Novelty place preference	0.5	0.5	0.7	0.6	0.7	0.6	-0.8	0.8	0.9	0.6
Time in novel zone, NPP test	0.5	0.5	0.8	0.5	0.7	0.6	-0.8	0.9	0.9	0.6
Total zone transitions, NPP test	0.3	0.4	1.5	-0.4	-0.1	-0.0	-0.3	0.9	0.6	1.2
Total locomotion distance, NPP test	0.4	0.5	1.0	0.5	0.5	0.6	-0.7	0.8	0.7	1.0
Locomotion velocity, NPP test	0.2	0.3	0.7	0.5	0.3	0.5	-0.6	0.6	0.5	0.8
Intraocular pressure	0.5	0.7	1.8	0.1	-0.4	-0.4	0.7	-1.1	-0.9	-1.3
Delta distance traveled before/after self-admin	0.2	0.2	0.5	-0.3	-0.4	-0.3	0.5	-0.6	-0.2	-0.7
Delta ambulatory time before/after self-admin	0.3	0.4	0.6	-0.5	-0.5	-0.3	0.7	-0.7	-0.7	-0.8
Parametrial fat weight	2.0	4.6	9.1	3.0	2.4	2.5	-2.3	1.6	1.6	0.8
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.4	0.5	0.4	-0.1	-0.1	-0.1	-0.3
Pavlov. Cond. magazine entry latency	0.8	1.1	1.5	0.8	1.0	1.0	-1.1	1.2	1.1	0.9
Pavlov. Cond. change in total contacts	0.7	0.7	0.9	0.9	0.9	0.9	-1.0	0.9	0.8	0.6
Pavlov. Cond. index score	0.0	0.0	0.1	0.3	0.1	0.1	-0.2	0.2	0.3	-0.0
Pavlov. Cond. latency score	0.1	0.1	0.2	0.3	0.1	0.2	-0.4	0.4	0.5	0.3
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.0	-0.2	-0.1	-0.1	0.2	0.3	0.3
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.4	-0.1	-0.1	0.2	-0.1	-0.2	0.3
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.7	-0.2	-0.4	-0.4	0.6	-0.8	-0.7	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	0.3	0.1	0.1	-0.2	0.2	0.3	0.1
Pavlov. Cond. response bias	0.0	0.0	0.2	0.3	-0.0	-0.0	-0.0	-0.0	0.1	-0.4
Pavlov. Cond. lever latency	0.0	0.0	0.2	0.0	0.2	0.2	-0.2	0.1	-0.1	0.4
Pavlov. Cond. magazine entry latency	0.5	0.6	1.5	-1.2	-0.3	-0.4	-0.1	0.9	0.5	1.2
Pavlov. Cond. change in total contacts	0.3	0.5	0.9	0.2	0.6	0.5	-0.7	0.9	0.8	0.8
Pavlov. Cond. index score	0.1	0.2	0.4	-0.4	0.1	-0.1	-0.2	0.6	0.5	0.6
Pavlov. Cond. latency score	0.1	0.1	0.3	-0.3	0.0	-0.1	-0.2	0.5	0.4	0.5
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.0	-0.1	-0.2	0.1	-0.0	0.2	-0.3
Pavlov. Cond. magazine entry number	0.6	0.7	1.9	1.4	0.4	0.5	-0.0	-0.8	-0.5	-1.3
Pavlov. Cond. intertrial magazine entries	0.2	0.3	1.3	1.1	0.5	0.6	-0.4	-0.1	0.2	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.5	-0.6	-0.1	-0.2	-0.1	0.6	0.4	0.7
Pavlov. Cond. response bias	0.1	0.2	0.4	-0.4	-0.0	-0.1	-0.2	0.6	0.5	0.6
Time in closed arm before self-admin	1.3	1.7	2.6	1.5	1.6	1.5	-1.4	1.2	0.8	0.9
Time in closed arm after self-admin	0.0	0.0	0.1	0.1	0.0	0.0	0.0	-0.1	-0.4	-0.1
Time in open arm before self-admin	1.6	1.7	3.1	-1.4	-1.6	-1.7	1.4	-1.2	-0.6	-1.0
Time in open arm after self-admin	0.2	0.2	0.5	-0.7	-0.5	-0.6	0.3	0.0	0.4	0.2
Bone: periosteal estimation	0.1	0.3	0.5	0.7	0.5	0.5	-0.6	0.5	0.5	0.1
Bone: periosteal perimeter	0.5	0.9	1.2	0.9	1.0	1.0	-1.1	1.1	0.9	0.8
Bone: post-yield work	7.9	11.6	15.9	2.3	3.1	3.2	-3.6	4.0	3.4	3.9
Progressive ratio test 1 active lever presses	0.0	0.0	0.2	-0.0	0.1	0.0	0.0	-0.1	-0.4	0.3
Progressive ratio test 1 breakpoint	0.0	0.0	0.2	-0.1	0.0	-0.0	0.1	-0.1	-0.4	0.3
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	-0.0	0.3	0.1	-0.1	0.0	-0.6	0.4
Progressive ratio test 2 active lever presses	1.2	1.4	2.7	1.6	1.5	1.4	-1.3	0.9	0.5	0.6
Progressive ratio test 2 breakpoint	1.1	1.2	2.4	1.5	1.4	1.3	-1.2	0.8	0.4	0.5
Progressive ratio test 2 inactive lever presses	3.7	6.1	12.2	3.5	3.0	3.0	-2.6	1.7	1.4	0.8
Incentive Sensitization - Responses	0.5	0.7	1.1	0.6	0.9	0.7	-0.9	1.0	0.6	1.0
Incentive Sensitization - Breakpoint	0.6	0.8	1.2	0.8	1.0	0.9	-1.0	1.1	0.6	0.9
Sum of active levers in priming session hrs 5-6	4.1	3.8	5.8	-1.2	-1.6	-1.6	1.9	-2.2	-2.4	-2.4
Progressive ratio	1.9	3.0	6.2	0.3	1.2	1.3	-1.5	2.2	2.2	2.5
Food seeking constrained by brief footshock	0.0	0.0	0.1	-0.2	0.3	0.1	-0.1	0.3	0.1	0.3
Seeking ratio, punishment vs. effort	0.9	1.4	3.5	0.1	-0.5	-0.7	0.9	-1.5	-1.5	-1.9
Retroperitoneal fat weight	3.3	14.1	35.7	6.0	4.4	4.5	-3.7	1.9	2.5	-0.3
Reaction time number correct	0.7	1.3	1.6	-1.2	-1.3	-1.2	1.2	-1.1	-1.0	-0.8
Reaction time mean minus median	0.2	0.5	2.0	-1.4	-0.7	-0.4	0.5	0.2	-0.4	0.7
Reaction time mean minus median AUC	0.4	1.0	2.8	-1.7	-1.1	-0.9	1.0	-0.5	-0.8	0.2
Reaction time num false alarms	0.9	1.3	1.8	-0.8	-1.1	-1.0	1.2	-1.3	-1.0	-1.2
Reaction time num false alarms AUC	1.1	1.6	2.1	-1.4	-1.5	-1.2	1.4	-1.3	-1.1	-1.1
Reaction time trials correct on left	0.7	1.3	1.6	-1.2	-1.3	-1.2	1.2	-1.1	-1.0	-0.8
Reaction time trials on left	0.8	1.6	2.0	-1.3	-1.4	-1.4	1.4	-1.2	-1.1	-0.9
Reaction time mean	0.3	0.4	0.6	0.5	0.6	0.7	-0.7	0.8	0.7	0.5
Reaction time mean AUC	0.4	0.6	0.8	0.6	0.7	0.9	-0.8	0.9	0.8	0.7
Median of all reaction times	0.8	1.1	1.3	1.1	1.0	1.1	-1.1	1.1	1.2	0.7
Reaction time omissions	0.8	1.2	3.1	-1.8	-1.4	-1.2	1.1	-0.5	-0.8	0.1
Reaction time false alarm rate	0.3	0.5	0.6	-0.6	-0.7	-0.6	0.8	-0.8	-0.6	-0.7
Reaction time premature initiation rate	1.2	1.6	4.5	-2.1	-1.5	-1.4	1.2	-0.6	-0.8	0.3
Reaction time premature initiations	2.3	4.1	8.6	-2.9	-2.4	-2.2	2.1	-1.4	-1.6	-0.4
Std. dev. reaction times	0.1	0.1	0.4	-0.7	-0.2	0.1	0.1	0.3	-0.1	0.5
Reaction time trials completed	0.8	1.6	2.0	-1.3	-1.4	-1.4	1.4	-1.2	-1.1	-0.9
Reaction time trials AUC	0.6	1.2	1.5	-1.1	-1.2	-1.2	1.2	-1.1	-0.9	-0.8
Run reversals in cocaine runway, females	0.4	0.4	1.3	-0.2	0.1	0.2	-0.4	0.8	0.6	1.1
Run reversals in cocaine runway, males	0.8	0.8	1.3	-0.7	-0.9	-0.8	1.0	-1.1	-0.5	-1.1
Latency to leave start box in cocaine runway	1.3	1.5	2.1	1.1	1.2	1.2	-1.4	1.4	1.1	1.1
Latency to leave start box in cocaine runway, F	1.0	1.2	1.6	0.9	1.1	1.0	-1.2	1.3	1.2	1.0
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.1	0.1	0.1	-0.2	0.2	-0.2	0.2
Std. dev. time between licks in bursts	1.8	2.4	3.1	-1.4	-1.8	-1.7	1.7	-1.6	-1.3	-1.2
Total sessions with >9 infusions	0.2	0.2	0.8	-0.2	0.4	0.2	-0.3	0.5	0.0	0.9
Short access day 1 total inactive lever presses	0.8	1.0	2.0	1.4	1.4	1.3	-1.0	0.6	0.6	0.1
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.1	0.3	0.3	-0.2	0.2	-0.1	0.1
Short access day 1 total infusions	0.9	1.2	2.3	1.3	1.5	1.3	-1.2	0.9	0.6	0.7
Short access day 10 total infusions	2.2	2.9	4.1	1.1	1.8	1.7	-1.8	1.9	1.2	2.0
Short access total infusions	0.9	1.1	2.0	0.6	1.1	0.9	-1.0	1.1	0.8	1.4
Short access day 1 locomotion	0.8	0.9	1.8	1.1	1.3	1.2	-1.1	0.8	0.2	0.6
Short access day 10 total locomotion	0.8	1.4	2.3	1.1	1.5	1.4	-1.3	1.2	0.4	1.0
Short access total locomotion	1.1	1.3	2.3	1.2	1.5	1.3	-1.3	1.0	0.3	1.0
One hour access (0.3 mA shock)	3.0	3.5	7.0	2.6	2.3	2.2	-1.9	1.3	1.3	0.7
Compulsive drug intake	3.2	3.8	7.0	-2.6	-2.1	-2.1	2.1	-1.7	-1.6	-0.9
One hour access (shock baseline)	3.4	5.2	11.4	3.4	2.8	2.8	-2.4	1.5	1.2	0.6
Social response proportion	0.1	0.1	0.5	-0.5	-0.1	-0.0	-0.1	0.4	0.1	0.7
Social responses	0.6	0.8	1.2	-1.1	-1.1	-1.0	0.9	-0.7	-0.9	-0.1
Social time	0.3	0.4	1.1	-0.9	-0.8	-1.0	0.5	-0.2	-0.3	0.3
Soleus weight	0.7	2.0	6.8	2.6	1.4	1.5	-0.8	-0.4	-0.0	-1.5
Bone: stiffness	0.6	1.0	2.3	-0.0	0.6	0.6	-1.0	1.5	1.1	1.5
Tibialis anterior weight	8.0	27.0	39.2	-6.3	-5.9	-5.8	5.4	-4.2	-5.1	-2.9
Time to tail flick, vehicle, before self-admin	1.2	1.3	2.5	0.5	0.9	1.0	-1.1	1.4	1.6	1.1
Time to tail flick, vehicle, after self-admin	0.7	0.9	3.5	-0.6	0.1	0.4	-0.4	1.0	1.0	1.9
Time to tail flick, test, before self-admin	2.8	2.9	3.4	1.5	1.7	1.5	-1.8	1.9	1.7	1.8
Time to tail flick, test, after self-admin	0.1	0.1	0.5	-0.0	-0.3	-0.0	0.2	-0.2	-0.3	-0.7
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.9	-0.8	-0.5	-0.5	0.3	0.0	-0.4	0.9
Delta time to tail flick, test, before/after SA	5.1	5.3	6.8	-1.9	-2.4	-2.0	2.4	-2.5	-2.2	-2.6
Tibia length	0.9	2.4	3.4	-1.2	-1.5	-1.3	1.6	-1.7	-1.6	-1.8
Ambulatory time before self-admin	0.3	0.4	0.9	0.4	0.5	0.4	-0.8	1.0	0.4	0.8
Ambulatory time after self-admin	1.1	1.3	1.9	1.4	1.2	1.3	-1.3	1.2	0.7	0.6
Bone: tissue strength	0.3	0.3	0.4	0.6	0.6	0.6	-0.6	0.6	0.5	0.4
Total heroin consumption	1.7	2.0	5.0	-2.2	-1.8	-1.7	1.4	-0.7	-0.7	0.1
Bone: trabecular number	1.5	2.5	5.0	0.4	1.1	1.1	-1.5	2.1	2.0	2.2
Bone: trabecular spacing	0.4	0.5	1.3	0.0	-0.4	-0.4	0.5	-0.9	-1.1	-0.9
Bone: trabecular thickness	2.1	2.6	4.5	1.2	1.5	1.5	-1.6	1.7	2.1	1.5
Bone: trabecular tissue density	1.0	1.5	4.7	2.2	1.0	1.0	-0.5	-0.6	-0.3	-1.7
Water consumed over 24 hours	0.1	0.1	0.4	-0.6	-0.2	-0.2	0.0	0.4	0.3	0.3
Number of responses in last shaping day	0.2	0.2	0.4	-0.5	-0.4	-0.6	0.4	-0.4	-0.7	0.2