Hub : Genes

R3hcc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability R3hcc1 0.07 0.06 4.7e-06 0.04 0.04 0.04 0.04 1.0e-05 1.3e-05 1.1e-05 1.1e-05
2 Liver gene expression R3hcc1 0.43 0.23 0.0e+00 0.37 0.37 0.37 0.37 1.1e-42 1.0e-42 7.9e-43 3.5e-43
3 pVTA gene expression R3hcc1 0.1 0.09 2.8e-06 0.07 0.07 0.07 0.07 5.0e-06 2.3e-06 2.0e-06 2.4e-06
4 IC gene expression R3hcc1 0.07 0.08 5.0e-03 0.05 0.03 0.04 0.04 3.2e-03 1.4e-02 6.5e-03 9.4e-03
5 IC mRNA stability R3hcc1 0.12 0.11 2.5e-04 0.08 0.08 0.08 0.08 2.1e-04 3.7e-04 2.9e-04 3.5e-04
6 pVTA mRNA stability R3hcc1 0.04 0.04 5.5e-03 0.02 0.02 0.01 0.02 4.3e-03 5.9e-03 3.9e-02 5.4e-03
7 Adipose gene expression R3hcc1 0.74 0.2 1.0e-10 0.08 0.08 0.08 0.08 2.7e-09 4.7e-09 4.7e-09 5.3e-09
8 PL gene expression R3hcc1 0.1 0.09 1.6e-08 0.07 0.07 0.07 0.07 2.9e-08 2.0e-08 2.4e-08 2.5e-08
9 BLA gene expression R3hcc1 0.16 0.14 7.4e-06 0.08 0.08 0.08 0.08 4.9e-05 4.1e-05 4.5e-05 4.6e-05
10 NAcc gene expression R3hcc1 0.06 0.06 9.1e-08 0.04 0.04 0.04 0.04 3.1e-07 3.7e-07 2.7e-07 3.8e-07
11 Brain gene expression R3hcc1 0.1 0.09 1.3e-07 0.07 0.08 0.07 0.07 4.0e-07 5.8e-08 3.3e-07 1.9e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density1.22.22.5-1.51.51.61.5-1.5-1.5-1.5-1.5-1.51.4-1.5
Area under the delay curve0.10.10.10.3-0.3-0.4-0.30.30.30.40.30.3-0.20.3
BMI with tail0.51.62.11.5-1.5-1.2-1.31.31.31.21.21.2-1.21.2
BMI without tail0.00.00.00.2-0.2-0.0-0.10.10.10.10.00.00.1-0.0
Body weight0.72.93.41.8-1.8-1.6-1.81.81.81.71.61.6-1.71.6
Weight adjusted by age0.72.22.41.5-1.5-1.5-1.41.41.41.51.51.5-1.51.5
Bone surface0.61.11.3-1.11.11.11.1-1.1-1.1-1.1-1.0-1.01.0-1.0
Bone volume0.61.21.4-1.11.11.21.1-1.1-1.1-1.1-1.1-1.11.1-1.1
Breakpoint value in progressive ratio session0.10.20.20.4-0.4-0.3-0.50.50.50.40.30.3-0.30.3
Number of licking bursts0.00.00.00.1-0.1-0.10.1-0.1-0.10.10.00.00.10.0
Context. condit. distance diff. score0.81.01.1-0.80.81.01.0-1.0-1.0-1.0-1.0-1.01.1-1.0
Locomotion velocity, session 10.20.20.30.5-0.5-0.5-0.50.50.50.50.50.5-0.50.5
Locomotion distance, session 10.00.00.00.0-0.00.00.1-0.1-0.1-0.1-0.1-0.10.1-0.1
Locomotion velocity, session 20.00.00.1-0.30.30.20.1-0.1-0.1-0.1-0.2-0.20.1-0.1
Locomotion distance, session 20.00.00.1-0.20.20.20.1-0.1-0.1-0.1-0.1-0.10.1-0.1
Locomotion velocity, session 30.50.60.70.8-0.8-0.8-0.80.80.80.80.80.8-0.80.8
Locomotion distance, session 30.00.00.0-0.10.10.10.1-0.1-0.1-0.1-0.1-0.10.2-0.2
Stereotopy head waving bouts, day 30.70.91.00.8-0.8-1.0-1.01.01.01.00.90.9-0.91.0
Stereotopy head waving duration, day 32.42.93.21.6-1.6-1.8-1.71.71.71.71.71.7-1.71.7
Locomotion velocity, session 73.94.34.6-1.91.92.12.1-2.1-2.1-2.1-2.1-2.12.1-2.1
Locomotion distance, session 73.13.94.3-1.91.92.12.0-2.0-2.0-2.0-2.0-2.02.0-2.0
Stereotopy head waving bouts, day 71.31.51.80.9-0.9-1.2-1.31.31.31.31.31.3-1.31.3
Stereotopy head waving duration, day 71.92.32.51.4-1.4-1.5-1.51.51.51.51.51.5-1.61.6
Locomotion velocity, session 80.00.00.1-0.20.20.0-0.00.00.00.0-0.0-0.0-0.00.0
Locomotion distance, session 80.60.80.9-0.90.90.90.9-0.9-0.9-0.9-0.9-0.90.9-0.9
Degree of sensitization distance4.34.64.9-2.22.22.22.1-2.1-2.1-2.1-2.1-2.12.1-2.1
Degree of sensitization stereotypy0.91.01.20.8-0.8-1.0-1.01.01.01.01.01.0-1.11.1
Conditioned locomotion0.00.00.1-0.20.20.20.2-0.2-0.2-0.2-0.2-0.20.2-0.2
Cocaine response after cond. corrected0.20.30.40.7-0.7-0.6-0.60.60.60.50.60.6-0.60.5
Cocaine response after cond. not corrected0.10.20.30.5-0.5-0.5-0.40.40.40.40.40.4-0.40.4
Cocaine response before conditioning0.20.20.4-0.60.60.40.4-0.4-0.4-0.4-0.4-0.40.4-0.4
Saline control response0.10.10.2-0.40.40.40.3-0.3-0.3-0.4-0.4-0.40.3-0.4
Bone: connectivity density2.54.04.3-2.02.02.12.0-2.0-2.0-2.0-2.0-2.01.9-2.0
Bone: cortical apparent density0.00.10.1-0.20.20.20.3-0.3-0.3-0.3-0.3-0.30.3-0.3
Bone: cortical area0.00.00.00.1-0.10.10.0-0.0-0.0-0.0-0.0-0.0-0.0-0.0
Bone: cortical porosity1.11.21.31.0-1.0-1.1-1.11.11.11.11.11.1-1.11.1
Bone: cortical porosity0.60.70.70.7-0.7-0.8-0.90.90.90.90.80.8-0.90.9
Bone: cortical thickness0.00.00.0-0.10.10.00.0-0.0-0.0-0.0-0.0-0.00.0-0.0
Bone: cortical thickness0.00.00.0-0.10.10.00.0-0.0-0.0-0.0-0.0-0.00.0-0.0
Bone: cortical tissue density0.10.10.1-0.30.30.30.3-0.3-0.3-0.3-0.3-0.30.3-0.3
Condit. Reinf. active minus inactive responses0.60.71.01.0-1.0-0.9-0.70.70.70.70.80.8-0.70.8
Condit. Reinf. active-inactive response ratio2.42.53.01.6-1.6-1.7-1.51.51.51.51.61.6-1.51.6
Condit. Reinf. active responses0.00.00.00.2-0.2-0.1-0.10.10.10.10.10.1-0.00.1
Condit. Reinf. inactive responses2.33.03.2-1.71.71.81.7-1.7-1.7-1.7-1.7-1.71.7-1.7
Incentive salience index mean0.91.11.61.3-1.3-1.1-1.01.01.01.01.01.0-1.01.0
Condit. Reinf. lever presses0.40.61.01.0-1.0-0.7-0.70.70.70.70.70.7-0.70.7
Condit. Reinf. active minus inactive responses0.30.51.0-1.01.00.60.7-0.7-0.7-0.7-0.7-0.70.7-0.6
Condit. Reinf. active-inactive response ratio0.00.10.10.1-0.1-0.3-0.20.20.20.30.30.3-0.20.3
Condit. Reinf. active responses1.01.42.2-1.51.51.11.1-1.1-1.1-1.1-1.1-1.11.1-1.1
Condit. Reinf. inactive responses1.82.73.1-1.81.81.71.6-1.6-1.6-1.6-1.6-1.61.6-1.6
Condit. Reinf. lever presses0.20.20.3-0.60.60.40.5-0.5-0.5-0.4-0.4-0.40.5-0.4
Condit. Reinf. lever reinforcers received0.81.11.7-1.31.31.01.0-1.0-1.0-1.0-1.0-1.01.0-1.0
Conditioned reinforcement - actives0.41.71.7-1.31.31.31.3-1.3-1.3-1.3-1.3-1.31.3-1.3
Conditioned reinforcement - inactives1.74.64.8-2.02.02.12.2-2.2-2.2-2.1-2.1-2.12.1-2.1
Conditioned locomotion0.10.20.3-0.40.40.40.5-0.5-0.5-0.4-0.4-0.40.4-0.4
Patch foraging indifference point 0 sec1.23.44.1-2.02.01.81.8-1.8-1.8-1.8-1.8-1.81.7-1.8
Patch foraging indifference point AUC0.20.40.50.6-0.6-0.7-0.60.60.60.70.60.6-0.50.6
Delay disc. indifference point, 0s delay0.30.30.4-0.50.50.50.6-0.6-0.6-0.5-0.6-0.60.6-0.6
Delay disc. indifference point, 16s delay0.20.20.3-0.40.40.40.5-0.5-0.5-0.4-0.5-0.50.5-0.5
Delay disc. indifference point, 2s delay1.51.71.71.3-1.3-1.3-1.31.31.31.31.31.3-1.31.3
Delay disc. indifference point, 24s delay0.10.20.30.5-0.5-0.5-0.40.40.40.50.40.4-0.40.4
Delay disc. indifference point, 4s delay1.82.02.11.4-1.4-1.4-1.41.41.41.51.41.4-1.31.4
Delay disc. indifference point, 8s delay0.00.00.0-0.10.10.10.1-0.1-0.1-0.1-0.1-0.10.2-0.2
Indifference point function ln k0.00.00.0-0.10.10.10.1-0.1-0.1-0.2-0.1-0.10.0-0.1
Indifference point function log k0.00.00.0-0.10.10.10.1-0.1-0.1-0.2-0.1-0.10.0-0.1
Patch foraging total patch changes 0 sec0.82.43.0-1.71.71.61.5-1.5-1.5-1.6-1.5-1.51.5-1.5
Patch foraging total patch changes 12 sec0.60.81.0-1.01.00.80.9-0.9-0.9-0.9-0.9-0.90.9-0.9
Patch foraging total patch changes 18 sec0.81.92.4-1.61.61.31.3-1.3-1.3-1.3-1.4-1.41.4-1.4
Patch foraging total patch changes 24 sec0.00.00.00.1-0.1-0.2-0.10.10.1-0.00.00.0-0.00.0
Patch foraging total patch changes 6 sec0.20.30.5-0.70.70.50.5-0.5-0.5-0.5-0.6-0.60.5-0.5
Patch foraging time to switch 0 sec0.31.11.3-1.01.01.01.1-1.1-1.1-1.1-1.0-1.01.0-1.1
Patch foraging water rate 0 sec0.10.50.60.7-0.7-0.6-0.70.70.70.80.70.7-0.70.7
Patch foraging water rate 12 sec0.21.01.11.0-1.0-0.9-1.01.01.01.11.01.0-1.01.0
Patch foraging water rate 18 sec1.73.94.31.9-1.9-1.9-2.02.02.02.02.02.0-2.12.0
Patch foraging water rate 24 sec0.10.20.30.3-0.3-0.2-0.40.40.40.40.40.4-0.50.4
Patch foraging water rate 6 sec2.03.03.41.8-1.8-1.7-1.71.71.71.81.71.7-1.71.7
Seeking ratio, delayed vs. immediate footshock1.01.51.8-1.31.31.21.4-1.4-1.4-1.1-1.1-1.11.1-1.1
Distance traveled before self-admin0.40.91.21.1-1.1-1.1-0.80.80.80.91.01.0-0.91.0
Distance traveled after self-admin1.62.93.21.5-1.5-1.7-1.71.71.71.81.81.8-1.81.8
Extensor digitorum longus weight13.051.954.57.4-7.4-7.3-7.27.27.27.27.27.2-7.17.1
Bone: elastic displacement0.40.40.5-0.70.70.60.7-0.7-0.7-0.7-0.7-0.70.7-0.7
Bone: elastic work0.20.20.3-0.40.40.50.5-0.5-0.5-0.5-0.5-0.50.5-0.5
Bone: endosteal estimation0.10.10.20.5-0.5-0.3-0.30.30.30.30.30.3-0.40.3
Bone: endosteal perimeter0.00.10.20.4-0.4-0.2-0.20.20.20.20.20.2-0.30.2
Epididymis fat weight0.52.42.7-1.51.51.61.5-1.5-1.5-1.7-1.6-1.61.6-1.6
Delta time in closed arm before/after self-admin4.24.04.2-2.02.01.92.1-2.1-2.1-2.0-1.9-1.92.0-2.0
Delta time in open arm before/after self-admin0.10.10.20.2-0.2-0.2-0.20.20.20.40.20.2-0.30.3
Diff in mean of infusions in LGA sessions0.81.42.01.4-1.4-1.2-1.11.11.11.11.11.1-1.11.1
Delay discount exponential model param0.40.50.6-0.70.70.70.7-0.7-0.7-0.7-0.7-0.70.6-0.7
Extinction: sum of active levers before priming1.52.32.7-1.61.61.51.5-1.5-1.5-1.4-1.5-1.51.5-1.5
Active lever presses in extinction session 60.50.50.7-0.50.50.50.8-0.8-0.8-0.6-0.7-0.70.8-0.7
Bone: final force0.10.20.40.6-0.6-0.4-0.40.40.40.40.40.4-0.40.4
Bone: final moment0.10.10.30.6-0.6-0.3-0.30.30.30.30.30.3-0.40.3
Food consumed during 24 hour testing period0.20.30.3-0.50.50.50.6-0.6-0.6-0.5-0.6-0.60.6-0.6
Glucose0.00.00.10.3-0.3-0.10.1-0.1-0.10.00.00.00.0-0.0
Heart weight0.40.60.8-0.70.70.90.9-0.9-0.9-0.8-0.8-0.80.8-0.8
Delay discount hyperbolic model param0.50.60.7-0.80.80.80.8-0.8-0.8-0.8-0.8-0.80.7-0.8
Intermittent access intake day 1-15 change0.63.54.0-2.02.01.91.8-1.8-1.8-1.9-1.9-1.91.9-1.9
Intermittent access intake escalation0.73.74.2-2.02.01.91.9-1.9-1.9-1.9-1.9-1.91.9-1.9
Intermittent access intake escalation 21.01.71.9-1.41.41.31.3-1.3-1.3-1.3-1.3-1.31.3-1.3
Intermitt. access day 1 inactive lever presses0.00.00.0-0.10.10.10.2-0.2-0.2-0.1-0.1-0.10.1-0.1
Intermitt. access day 15 inactive lever presses0.00.10.1-0.10.10.20.3-0.3-0.3-0.2-0.2-0.20.2-0.2
Intermitt. access escalation Index0.00.10.10.4-0.4-0.2-0.30.30.30.20.30.3-0.20.2
Intermittent access day 1 total infusions0.00.00.00.1-0.1-0.00.2-0.2-0.20.10.00.00.00.0
Intermittent access day 15 total infusions1.12.73.0-1.61.61.61.7-1.7-1.7-1.6-1.6-1.61.6-1.6
Intermittent access terminal intake (last 3 days)0.91.51.8-1.21.21.21.3-1.3-1.3-1.2-1.2-1.21.2-1.2
Intermittent access total infusions1.31.51.7-1.21.21.21.3-1.3-1.3-1.2-1.2-1.21.2-1.2
Intermittent access day 1 locomotion0.00.00.0-0.00.00.10.1-0.1-0.1-0.0-0.1-0.10.1-0.1
Intermittent access day 15 total locomotion0.10.50.6-0.70.70.60.8-0.8-0.8-0.6-0.6-0.60.7-0.6
Intermittent access total locomotion0.10.10.2-0.40.40.30.4-0.4-0.4-0.3-0.3-0.30.4-0.3
Intermittent access standard deviation0.10.30.3-0.60.60.50.5-0.5-0.5-0.5-0.5-0.50.5-0.5
Left kidney weight0.00.20.20.4-0.4-0.3-0.40.40.40.50.40.4-0.40.4
Right kidney weight0.00.10.10.2-0.2-0.1-0.30.30.30.30.20.2-0.20.2
Cocaine induced anxiety0.00.00.00.1-0.1-0.1-0.00.00.00.00.10.1-0.00.1
Post-drug Anxiety0.80.91.0-0.90.90.91.0-1.0-1.0-1.0-1.0-1.01.0-1.0
Baseline Anxiety0.30.50.5-0.60.60.60.7-0.7-0.7-0.7-0.7-0.70.7-0.7
Tail length0.31.82.0-1.41.41.41.3-1.3-1.3-1.3-1.4-1.41.4-1.4
Length with tail0.00.20.20.4-0.4-0.3-0.40.40.40.40.40.4-0.40.4
Length without tail1.37.17.72.8-2.8-2.6-2.62.62.62.62.72.7-2.72.6
Times rat made contact with spout0.50.60.7-0.80.80.70.8-0.8-0.8-0.7-0.8-0.80.8-0.8
Lifetime Intake0.70.91.1-0.90.90.91.1-1.1-1.1-0.9-0.9-0.90.9-0.9
Liver weight, left1.93.33.71.9-1.9-1.8-1.91.91.91.81.81.8-1.81.7
Liver weight, right0.50.91.10.9-0.9-0.9-1.01.01.00.90.90.9-1.00.9
Locomotor activity1.42.22.61.3-1.3-1.6-1.41.41.41.61.61.6-1.61.6
Locomotor testing distance0.00.10.2-0.50.50.20.3-0.3-0.3-0.1-0.2-0.20.3-0.2
Locomotor testing rearing0.10.30.7-0.80.80.50.5-0.5-0.5-0.5-0.5-0.50.5-0.5
Locomotion in novel chamber0.50.60.7-0.80.80.80.8-0.8-0.8-0.7-0.8-0.80.7-0.8
Locomotion in novel chamber post-restriction0.30.91.10.9-0.9-0.9-0.80.80.81.01.01.0-1.01.0
Fecal boli incidents, locomotor time 10.61.51.81.2-1.2-1.3-1.31.31.31.11.21.2-1.21.2
Change in fecal boli incidents, locomotor task0.20.30.40.6-0.6-0.5-0.40.40.40.50.50.5-0.50.5
Time >=10cm from walls, locomotor time 10.70.91.0-0.80.80.90.9-0.9-0.9-1.0-1.0-1.01.0-1.0
Bouts of movement, locomotor time 14.45.75.92.4-2.4-2.4-2.42.42.42.42.42.4-2.32.3
Total resting periods, locomotor time 14.85.55.72.4-2.4-2.4-2.42.42.42.32.32.3-2.32.3
Rest time, locomotor task time 11.52.52.81.7-1.7-1.6-1.61.61.61.51.51.5-1.51.5
Distance moved, locomotor task time 11.23.43.8-2.02.01.81.8-1.8-1.8-1.7-1.8-1.81.9-1.8
Vertical activity count, locomotor time 10.21.31.4-1.21.21.11.2-1.2-1.2-1.1-1.1-1.11.1-1.1
Time >=10cm from walls, locomotor time 20.20.40.50.7-0.7-0.6-0.60.60.60.70.70.7-0.70.7
Bouts of movement, locomotor time 21.65.25.52.2-2.2-2.3-2.32.32.32.42.32.3-2.32.3
Total resting periods, locomotor time 21.45.65.82.3-2.3-2.4-2.42.42.42.42.42.4-2.42.4
Rest time, locomotor task time 20.61.11.31.2-1.2-1.0-1.01.01.01.01.01.0-1.01.0
Distance moved, locomotor task time 22.73.64.0-2.02.01.91.9-1.9-1.9-1.8-1.9-1.91.9-1.9
Vertical activity count, locomotor time 20.20.50.6-0.70.70.70.7-0.7-0.7-0.7-0.7-0.70.7-0.7
Light reinforcement 11.25.45.9-2.42.42.42.3-2.3-2.3-2.4-2.3-2.32.3-2.3
Light reinforcement 20.51.21.4-0.80.81.11.1-1.1-1.1-1.2-1.1-1.11.2-1.2
Bone: marrow area0.00.10.10.4-0.4-0.1-0.20.20.20.20.20.2-0.20.2
Bone: maximum diameter0.30.60.80.9-0.9-0.7-0.80.80.80.80.80.8-0.80.8
Bone: maximum force0.30.50.60.7-0.7-0.7-0.70.70.70.70.70.7-0.70.7
Bone: maximum moment0.20.30.40.6-0.6-0.5-0.50.50.50.50.50.5-0.60.5
Mean time between licks in bursts0.42.52.7-1.41.41.61.7-1.7-1.7-1.6-1.6-1.61.7-1.6
Mean num. licks in bursts0.10.40.6-0.80.80.60.5-0.5-0.5-0.6-0.6-0.60.5-0.6
Cd content in liver1.21.31.51.2-1.2-1.2-1.11.11.11.11.21.2-1.11.1
Co content in liver5.26.16.62.6-2.6-2.5-2.42.42.42.42.42.4-2.42.4
Cu content in liver0.50.60.80.9-0.9-0.8-0.70.70.70.70.70.7-0.70.7
Fe content in liver1.62.02.1-1.41.41.41.4-1.4-1.4-1.4-1.4-1.41.4-1.4
K content in liver1.11.11.1-1.01.01.01.1-1.1-1.1-1.1-1.1-1.11.1-1.1
Mg content in liver2.52.82.9-1.71.71.61.7-1.7-1.7-1.7-1.7-1.71.7-1.7
Mn content in liver2.62.93.5-1.91.91.71.7-1.7-1.7-1.7-1.7-1.71.7-1.7
Na content in liver0.91.01.11.0-1.0-1.1-1.01.01.01.01.01.0-1.01.0
Rb content in liver0.00.00.1-0.30.30.20.2-0.2-0.2-0.2-0.2-0.20.1-0.2
Se content in liver0.91.11.1-1.11.11.11.1-1.1-1.1-1.1-1.1-1.11.0-1.1
Sr content in liver0.00.00.0-0.10.10.00.1-0.1-0.1-0.1-0.1-0.10.2-0.1
Zn content in liver0.10.10.2-0.20.20.30.4-0.4-0.4-0.4-0.3-0.30.4-0.4
Bone: minimum diameter0.10.30.40.7-0.7-0.4-0.50.50.50.50.50.5-0.50.5
Time in familiar zone, hab. session 10.00.00.00.1-0.1-0.1-0.10.10.10.10.10.1-0.20.2
Time in novel zone, hab. session 11.11.21.41.1-1.1-1.2-1.11.11.11.11.11.1-1.11.1
Total zone transitions, hab. session 10.20.30.40.4-0.4-0.6-0.60.60.60.60.60.6-0.50.6
Total locomotion distance, hab. session 10.00.00.0-0.10.1-0.1-0.00.00.00.0-0.0-0.00.1-0.0
Locomotion velocity, hab. session 10.10.10.2-0.40.40.30.3-0.3-0.3-0.3-0.3-0.30.3-0.3
Time in familiar zone, hab. session 21.92.22.21.5-1.5-1.4-1.51.51.51.51.51.5-1.51.5
Time in novel zone, hab. session 20.70.80.9-1.01.00.80.9-0.9-0.9-0.9-0.9-0.90.9-0.9
Total zone transitions, hab. session 21.41.82.01.4-1.4-1.4-1.31.31.31.31.31.3-1.31.3
Total locomotion distance, hab. session 20.30.30.50.7-0.7-0.6-0.60.60.60.60.60.6-0.50.6
Locomotion velocity, hab. session 20.60.81.01.0-1.0-0.9-0.90.90.90.90.90.9-0.80.9
Novel to familiar place preference ratio1.31.71.8-1.31.31.31.3-1.3-1.3-1.3-1.3-1.31.3-1.3
Novelty place preference1.11.31.4-1.21.21.11.2-1.2-1.2-1.2-1.2-1.21.2-1.2
Time in novel zone, NPP test0.60.70.7-0.90.90.80.8-0.8-0.8-0.8-0.8-0.80.9-0.8
Total zone transitions, NPP test0.10.20.2-0.50.50.40.4-0.4-0.4-0.4-0.4-0.40.5-0.4
Total locomotion distance, NPP test2.53.53.6-1.91.91.81.9-1.9-1.9-1.9-1.9-1.91.9-1.9
Locomotion velocity, NPP test2.43.43.5-1.91.91.81.8-1.8-1.8-1.8-1.8-1.81.9-1.8
Intraocular pressure0.40.70.7-0.80.80.70.9-0.9-0.9-0.9-0.8-0.80.9-0.8
Delta distance traveled before/after self-admin2.93.23.81.4-1.4-1.7-1.91.91.91.91.81.8-1.81.8
Delta ambulatory time before/after self-admin1.93.23.71.5-1.5-1.7-1.91.91.91.91.81.8-1.81.9
Parametrial fat weight2.14.95.5-2.32.32.32.2-2.2-2.2-2.2-2.2-2.22.1-2.1
Pavlov. Cond. lever latency0.00.00.00.1-0.1-0.00.0-0.0-0.0-0.0-0.0-0.00.0-0.0
Pavlov. Cond. magazine entry latency0.00.00.1-0.20.20.20.1-0.1-0.1-0.1-0.2-0.20.1-0.1
Pavlov. Cond. change in total contacts1.11.21.41.0-1.0-1.1-1.21.21.21.21.11.1-1.11.1
Pavlov. Cond. index score0.10.10.10.2-0.2-0.3-0.30.30.30.30.30.3-0.30.3
Pavlov. Cond. latency score0.00.00.00.0-0.0-0.1-0.20.20.20.20.20.2-0.20.2
Pavlov. Cond. lever contacts0.00.00.0-0.10.10.10.1-0.1-0.1-0.1-0.1-0.10.1-0.1
Pavlov. Cond. magazine entry number0.40.50.5-0.60.60.70.7-0.7-0.7-0.7-0.7-0.70.7-0.7
Pavlov. Cond. intertrial magazine entries0.10.10.1-0.30.30.30.4-0.4-0.4-0.4-0.4-0.40.4-0.4
Pavlov. Cond. lever-magazine prob. diff.0.20.20.30.4-0.4-0.4-0.50.50.50.50.50.5-0.50.5
Pavlov. Cond. response bias0.10.20.20.3-0.3-0.4-0.50.50.50.50.40.4-0.50.4
Pavlov. Cond. lever latency0.40.50.6-0.70.70.80.7-0.7-0.7-0.8-0.7-0.70.7-0.7
Pavlov. Cond. magazine entry latency0.10.10.1-0.00.00.20.3-0.3-0.3-0.2-0.3-0.30.3-0.3
Pavlov. Cond. change in total contacts0.81.92.11.4-1.4-1.4-1.31.31.31.41.41.4-1.31.4
Pavlov. Cond. index score0.30.50.70.9-0.9-0.8-0.60.60.60.80.70.7-0.60.7
Pavlov. Cond. latency score0.20.40.70.8-0.8-0.6-0.50.50.50.60.60.6-0.50.6
Pavlov. Cond. lever contacts0.10.20.30.4-0.4-0.5-0.40.40.40.60.50.5-0.40.5
Pavlov. Cond. magazine entry number0.00.00.0-0.10.1-0.1-0.20.20.20.10.20.2-0.20.2
Pavlov. Cond. intertrial magazine entries3.67.98.2-2.82.82.92.8-2.8-2.8-2.8-2.8-2.82.8-2.8
Pavlov. Cond. lever-magazine prob. diff.0.40.70.91.0-1.0-0.9-0.70.70.70.90.80.8-0.70.8
Pavlov. Cond. response bias0.20.30.40.6-0.6-0.6-0.50.50.50.60.50.5-0.50.5
Time in closed arm before self-admin1.11.92.21.3-1.3-1.2-1.51.51.51.41.41.4-1.51.4
Time in closed arm after self-admin0.00.00.00.1-0.1-0.1-0.10.10.10.10.20.2-0.20.2
Time in open arm before self-admin0.00.00.00.2-0.2-0.20.1-0.1-0.1-0.10.00.00.10.0
Time in open arm after self-admin0.00.00.0-0.20.20.00.1-0.1-0.1-0.0-0.1-0.10.2-0.1
Bone: periosteal estimation0.00.10.20.5-0.5-0.2-0.20.20.20.20.30.3-0.30.3
Bone: periosteal perimeter0.00.00.10.3-0.3-0.1-0.20.20.20.20.20.2-0.20.2
Bone: post-yield work0.10.20.3-0.60.60.50.4-0.4-0.4-0.4-0.4-0.40.4-0.4
Progressive ratio test 1 active lever presses0.10.10.20.4-0.4-0.3-0.30.30.30.40.30.3-0.30.3
Progressive ratio test 1 breakpoint0.10.20.30.5-0.5-0.4-0.30.30.30.40.40.4-0.40.4
Progressive ratio test 1 inactive lever presses0.51.31.7-0.90.91.11.3-1.3-1.3-1.1-1.1-1.11.1-1.1
Progressive ratio test 2 active lever presses0.00.00.1-0.20.20.20.3-0.3-0.3-0.1-0.2-0.20.2-0.2
Progressive ratio test 2 breakpoint0.00.00.1-0.20.20.10.3-0.3-0.3-0.1-0.1-0.10.2-0.1
Progressive ratio test 2 inactive lever presses0.10.50.6-0.50.50.60.8-0.8-0.8-0.6-0.6-0.60.7-0.7
Incentive Sensitization - Responses0.10.40.4-0.60.60.60.6-0.6-0.6-0.5-0.6-0.60.6-0.6
Incentive Sensitization - Breakpoint0.20.50.5-0.70.70.70.7-0.7-0.7-0.7-0.7-0.70.7-0.7
Sum of active levers in priming session hrs 5-60.10.10.1-0.30.30.10.3-0.3-0.3-0.2-0.3-0.30.3-0.3
Progressive ratio0.00.00.00.1-0.1-0.1-0.10.10.10.20.10.1-0.10.1
Food seeking constrained by brief footshock2.12.63.21.8-1.8-1.7-1.51.51.51.71.61.6-1.61.6
Seeking ratio, punishment vs. effort0.41.01.11.1-1.1-1.0-0.90.90.90.91.01.0-1.01.0
Retroperitoneal fat weight0.10.50.6-0.80.80.80.6-0.6-0.6-0.7-0.7-0.70.7-0.7
Reaction time number correct0.31.01.11.0-1.0-0.9-1.01.01.01.01.01.0-1.01.0
Reaction time mean minus median0.00.10.30.5-0.5-0.4-0.30.30.30.20.40.4-0.40.3
Reaction time mean minus median AUC0.00.10.20.4-0.4-0.3-0.30.30.30.10.30.3-0.30.3
Reaction time num false alarms0.00.10.20.1-0.1-0.2-0.30.30.30.20.30.3-0.40.3
Reaction time num false alarms AUC0.00.00.10.0-0.0-0.1-0.20.20.20.10.20.2-0.30.2
Reaction time trials correct on left0.31.01.11.0-1.0-0.9-1.01.01.01.01.01.0-1.01.0
Reaction time trials on left0.20.80.80.9-0.9-0.8-0.90.90.90.90.90.9-0.90.9
Reaction time mean0.10.30.50.7-0.7-0.6-0.50.50.50.40.50.5-0.50.5
Reaction time mean AUC0.20.50.80.9-0.9-0.8-0.70.70.70.60.70.7-0.70.7
Median of all reaction times0.20.30.40.6-0.6-0.5-0.50.50.50.40.50.5-0.40.5
Reaction time omissions1.62.52.9-1.51.51.51.6-1.6-1.6-1.7-1.6-1.61.6-1.6
Reaction time false alarm rate0.10.20.3-0.50.50.40.4-0.4-0.4-0.4-0.3-0.30.3-0.3
Reaction time premature initiation rate1.72.72.91.7-1.7-1.6-1.61.61.61.51.61.6-1.71.6
Reaction time premature initiations1.33.94.32.1-2.1-1.9-2.02.02.01.92.02.0-2.01.9
Std. dev. reaction times0.10.20.30.6-0.6-0.5-0.40.40.40.20.40.4-0.40.4
Reaction time trials completed0.20.80.80.9-0.9-0.8-0.90.90.90.90.90.9-0.90.9
Reaction time trials AUC0.20.70.70.9-0.9-0.7-0.80.80.80.80.80.8-0.90.8
Run reversals in cocaine runway, females2.62.93.1-1.61.61.81.7-1.7-1.7-1.7-1.8-1.81.8-1.8
Run reversals in cocaine runway, males2.02.22.71.4-1.4-1.4-1.61.61.61.41.41.4-1.51.4
Latency to leave start box in cocaine runway0.30.40.50.7-0.7-0.6-0.50.50.50.60.70.7-0.60.7
Latency to leave start box in cocaine runway, F1.11.41.51.2-1.2-1.2-1.21.21.21.21.21.2-1.21.2
Latency to leave start box in cocaine runway, M0.10.10.3-0.30.30.30.6-0.6-0.6-0.3-0.3-0.30.3-0.3
Std. dev. time between licks in bursts0.81.61.8-1.01.01.31.3-1.3-1.3-1.3-1.3-1.31.3-1.3
Total sessions with >9 infusions0.00.10.10.3-0.3-0.2-0.20.20.20.30.20.2-0.20.2
Short access day 1 total inactive lever presses0.10.20.2-0.40.40.40.5-0.5-0.5-0.3-0.4-0.40.4-0.4
Short access day 10 total inactive lever presses0.00.30.4-0.40.40.50.6-0.6-0.6-0.5-0.5-0.50.5-0.5
Short access day 1 total infusions0.00.10.10.3-0.3-0.2-0.20.20.20.30.30.3-0.30.3
Short access day 10 total infusions0.20.40.50.7-0.7-0.6-0.50.50.50.70.60.6-0.60.6
Short access total infusions0.00.00.10.3-0.3-0.2-0.10.10.10.30.20.2-0.20.2
Short access day 1 locomotion0.61.01.11.0-1.0-1.0-0.90.90.91.11.01.0-1.01.0
Short access day 10 total locomotion0.00.00.0-0.10.10.10.0-0.0-0.0-0.0-0.1-0.10.1-0.1
Short access total locomotion0.10.10.20.4-0.4-0.3-0.40.40.40.40.40.4-0.40.4
One hour access (0.3 mA shock)0.70.91.0-1.01.00.90.9-0.9-0.9-0.9-0.9-0.90.9-0.9
Compulsive drug intake0.50.81.1-1.11.10.90.7-0.7-0.7-0.9-0.9-0.90.8-0.9
One hour access (shock baseline)0.00.00.00.1-0.1-0.00.1-0.1-0.10.00.00.00.00.0
Social response proportion0.10.10.20.1-0.1-0.3-0.40.40.40.30.30.3-0.40.4
Social responses1.11.52.1-1.41.41.21.1-1.1-1.1-1.1-1.2-1.21.2-1.2
Social time0.40.60.9-1.01.00.80.7-0.7-0.7-0.6-0.7-0.70.6-0.7
Soleus weight1.33.73.92.0-2.0-1.9-1.91.91.91.91.91.9-1.91.9
Bone: stiffness0.61.11.21.1-1.1-1.0-1.11.11.11.11.11.1-1.11.1
Tibialis anterior weight8.429.031.15.6-5.6-5.4-5.35.35.35.35.35.3-5.35.3
Time to tail flick, vehicle, before self-admin0.81.01.4-0.90.90.81.2-1.2-1.2-1.0-1.0-1.01.0-1.0
Time to tail flick, vehicle, after self-admin1.12.13.11.8-1.8-1.5-1.41.41.41.41.41.4-1.41.4
Time to tail flick, test, before self-admin2.62.93.1-1.71.71.71.7-1.7-1.7-1.7-1.7-1.71.8-1.7
Time to tail flick, test, after self-admin2.42.52.8-1.61.61.61.5-1.5-1.5-1.7-1.6-1.61.6-1.6
Delta time to tail flick, vehicle, before/after SA0.30.30.40.6-0.6-0.5-0.60.60.60.50.50.5-0.50.5
Delta time to tail flick, test, before/after SA0.00.00.0-0.10.10.20.1-0.1-0.1-0.2-0.1-0.10.1-0.1
Tibia length1.23.33.9-1.71.72.01.8-1.8-1.8-1.8-1.8-1.81.8-1.9
Ambulatory time before self-admin0.10.30.50.7-0.7-0.7-0.50.50.50.50.60.6-0.60.6
Ambulatory time after self-admin3.75.96.32.2-2.2-2.4-2.52.52.52.52.52.5-2.52.5
Bone: tissue strength0.10.10.1-0.30.30.30.2-0.2-0.2-0.2-0.2-0.20.2-0.2
Total heroin consumption0.60.80.90.9-0.9-0.7-0.90.90.90.90.80.8-0.90.8
Bone: trabecular number2.03.94.1-2.02.02.02.0-2.0-2.0-2.0-1.9-1.91.9-1.9
Bone: trabecular spacing2.13.13.31.8-1.8-1.7-1.71.71.71.71.71.7-1.71.7
Bone: trabecular thickness1.01.31.4-1.11.11.21.2-1.2-1.2-1.2-1.2-1.21.2-1.2
Bone: trabecular tissue density1.11.92.11.2-1.2-1.5-1.41.41.41.41.41.4-1.41.4
Water consumed over 24 hours0.91.71.91.4-1.4-1.4-1.31.31.31.41.31.3-1.31.3
Number of responses in last shaping day0.60.70.90.9-0.9-0.8-0.80.80.80.80.80.8-0.80.8