Hub : Genes

R3hcc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression R3hcc1 0.19 0.33 7.3e-11 0.08 0.08 0.08 0.08 2.0e-09 2.6e-09 2.0e-09 5.2e-09
2 Liver gene expression R3hcc1 0.41 0.23 0.0e+00 0.36 0.36 0.36 0.36 3.4e-42 6.0e-42 3.7e-42 3.4e-42
3 pVTA gene expression R3hcc1 0.13 0.12 2.9e-04 0.09 0.09 0.06 0.07 1.5e-04 1.2e-04 1.7e-03 4.3e-04
4 NAcc gene expression R3hcc1 0.05 0.05 4.5e-05 0.03 0.03 0.02 0.03 6.7e-05 9.1e-05 6.8e-04 1.3e-04
5 BLA gene expression R3hcc1 0.15 0.14 2.0e-05 0.07 0.07 0.07 0.07 7.4e-05 7.5e-05 1.4e-04 1.3e-04
6 PL mRNA stability R3hcc1 0.07 0.06 4.6e-06 0.04 0.04 0.03 0.04 4.7e-05 4.9e-05 1.1e-04 9.5e-05
7 PL gene expression R3hcc1 0.09 0.08 2.3e-08 0.06 0.06 0.06 0.06 1.9e-07 2.7e-07 5.6e-07 2.9e-07
8 Brain gene expression R3hcc1 0.09 0.08 4.0e-07 0.07 0.07 0.06 0.06 7.6e-07 1.7e-07 5.9e-06 1.5e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.52.52.8-1.61.7-1.61.51.5-1.51.6-1.6
Area under the delay curve0.00.00.10.2-0.30.2-0.1-0.10.1-0.30.2
BMI with tail0.41.41.61.2-1.11.2-1.2-1.21.2-1.11.2
BMI without tail0.71.51.6-1.21.3-1.21.21.3-1.31.3-1.2
Body weight0.41.71.81.4-1.31.3-1.3-1.31.3-1.31.3
Weight adjusted by age1.92.12.31.5-1.51.4-1.4-1.41.4-1.51.4
Bone surface0.61.11.2-1.01.1-1.01.01.0-1.01.1-1.0
Bone volume0.71.31.4-1.21.2-1.11.11.1-1.11.2-1.1
Breakpoint value in progressive ratio session0.10.10.10.2-0.40.2-0.2-0.20.2-0.40.2
Number of licking bursts0.00.00.00.1-0.00.1-0.1-0.10.1-0.00.1
Context. condit. distance diff. score0.91.11.1-1.01.0-1.01.01.0-1.01.0-1.0
Locomotion velocity, session 10.10.10.20.4-0.40.4-0.4-0.40.4-0.40.4
Locomotion distance, session 10.00.00.0-0.10.0-0.10.20.2-0.20.0-0.1
Locomotion velocity, session 20.00.00.1-0.30.2-0.20.20.2-0.20.2-0.2
Locomotion distance, session 20.00.00.0-0.20.2-0.20.20.2-0.20.2-0.2
Locomotion velocity, session 30.40.50.60.7-0.80.7-0.7-0.70.7-0.70.7
Locomotion distance, session 30.00.00.0-0.10.1-0.10.20.2-0.20.1-0.1
Stereotopy head waving bouts, day 30.70.81.10.9-1.00.9-0.9-0.80.8-1.00.9
Stereotopy head waving duration, day 32.73.23.51.8-1.91.8-1.8-1.71.7-1.91.8
Locomotion velocity, session 74.65.05.4-2.32.2-2.22.22.3-2.32.2-2.2
Locomotion distance, session 73.54.54.6-2.12.2-2.12.02.1-2.12.1-2.1
Stereotopy head waving bouts, day 71.71.92.11.5-1.31.4-1.5-1.31.3-1.31.4
Stereotopy head waving duration, day 72.53.03.21.8-1.71.7-1.8-1.71.7-1.61.7
Locomotion velocity, session 80.00.00.0-0.10.1-0.10.10.1-0.10.1-0.1
Locomotion distance, session 80.60.91.0-1.01.0-1.01.01.0-1.01.0-1.0
Degree of sensitization distance4.94.95.2-2.32.3-2.22.12.2-2.22.2-2.2
Degree of sensitization stereotypy1.11.21.41.2-1.01.1-1.2-1.11.1-1.01.1
Conditioned locomotion0.00.00.0-0.20.2-0.20.20.2-0.20.2-0.2
Cocaine response after cond. corrected0.20.30.30.5-0.50.5-0.5-0.50.5-0.50.5
Cocaine response after cond. not corrected0.20.20.20.4-0.40.4-0.4-0.40.4-0.40.4
Cocaine response before conditioning0.10.20.2-0.40.4-0.40.40.4-0.40.4-0.4
Saline control response0.20.30.3-0.50.5-0.50.50.5-0.50.4-0.5
Bone: connectivity density2.94.64.9-2.22.2-2.22.12.1-2.12.2-2.1
Bone: cortical apparent density0.00.00.0-0.20.1-0.20.20.2-0.20.1-0.2
Bone: cortical area0.00.00.0-0.10.1-0.10.00.1-0.10.1-0.1
Bone: cortical porosity1.41.51.61.3-1.21.2-1.3-1.31.3-1.21.2
Bone: cortical porosity0.60.60.60.8-0.70.8-0.8-0.80.8-0.70.8
Bone: cortical thickness0.00.00.0-0.20.2-0.20.10.2-0.20.2-0.2
Bone: cortical thickness0.00.00.1-0.20.2-0.20.20.2-0.20.2-0.2
Bone: cortical tissue density0.00.00.0-0.20.1-0.20.20.1-0.10.1-0.2
Condit. Reinf. active minus inactive responses0.50.50.80.7-0.90.8-0.7-0.60.6-0.90.7
Condit. Reinf. active-inactive response ratio2.32.53.01.6-1.71.6-1.5-1.41.4-1.71.6
Condit. Reinf. active responses0.00.00.0-0.0-0.10.00.00.1-0.1-0.10.0
Condit. Reinf. inactive responses2.93.43.6-1.91.9-1.91.91.8-1.81.8-1.9
Incentive salience index mean0.80.91.20.9-1.11.0-0.9-0.90.9-1.10.9
Condit. Reinf. lever presses0.20.30.40.5-0.60.6-0.5-0.60.6-0.60.5
Condit. Reinf. active minus inactive responses0.30.40.4-0.60.7-0.60.60.6-0.60.7-0.6
Condit. Reinf. active-inactive response ratio0.10.10.20.4-0.40.4-0.4-0.40.4-0.40.4
Condit. Reinf. active responses0.91.31.4-1.11.2-1.11.11.1-1.11.2-1.1
Condit. Reinf. inactive responses2.42.93.0-1.71.7-1.71.71.7-1.71.7-1.7
Condit. Reinf. lever presses0.10.10.1-0.30.3-0.30.30.3-0.30.3-0.3
Condit. Reinf. lever reinforcers received0.60.80.9-0.91.0-0.90.90.9-0.91.0-0.9
Conditioned reinforcement - actives2.72.72.9-1.71.6-1.71.71.7-1.71.6-1.6
Conditioned reinforcement - inactives3.03.33.6-1.91.8-1.91.81.8-1.81.7-1.9
Conditioned locomotion1.11.31.4-1.11.2-1.11.11.1-1.11.2-1.1
Patch foraging indifference point 0 sec2.23.63.6-1.91.9-1.91.91.9-1.91.9-1.9
Patch foraging indifference point AUC0.60.60.70.9-0.80.8-0.7-0.70.7-0.80.8
Delay disc. indifference point, 0s delay0.30.40.4-0.60.6-0.60.60.6-0.60.6-0.6
Delay disc. indifference point, 16s delay0.20.20.3-0.50.4-0.50.50.5-0.50.4-0.5
Delay disc. indifference point, 2s delay1.51.71.81.3-1.31.3-1.3-1.31.3-1.31.3
Delay disc. indifference point, 24s delay0.20.20.30.5-0.50.5-0.4-0.40.4-0.50.5
Delay disc. indifference point, 4s delay1.61.72.11.4-1.41.3-1.2-1.21.2-1.41.3
Delay disc. indifference point, 8s delay0.00.00.0-0.10.0-0.10.20.2-0.20.0-0.1
Indifference point function ln k0.00.00.0-0.10.2-0.10.10.1-0.10.2-0.1
Indifference point function log k0.00.00.0-0.10.2-0.10.10.1-0.10.2-0.1
Patch foraging total patch changes 0 sec1.93.03.1-1.71.8-1.71.71.7-1.71.7-1.7
Patch foraging total patch changes 12 sec0.81.01.1-1.01.0-1.01.01.0-1.01.0-1.0
Patch foraging total patch changes 18 sec2.02.62.8-1.61.5-1.61.71.7-1.71.5-1.6
Patch foraging total patch changes 24 sec0.00.00.0-0.10.0-0.10.20.2-0.20.0-0.1
Patch foraging total patch changes 6 sec0.30.50.5-0.70.7-0.70.70.7-0.70.7-0.7
Patch foraging time to switch 0 sec0.71.11.3-1.20.9-1.11.11.1-1.10.9-1.1
Patch foraging water rate 0 sec0.30.50.60.8-0.60.7-0.8-0.80.8-0.60.7
Patch foraging water rate 12 sec0.60.91.11.0-0.81.0-1.0-1.01.0-0.81.0
Patch foraging water rate 18 sec2.93.94.22.0-1.92.0-2.1-2.12.1-1.82.0
Patch foraging water rate 24 sec0.10.10.10.3-0.10.3-0.4-0.40.4-0.10.3
Patch foraging water rate 6 sec2.13.03.41.8-1.61.8-1.8-1.81.8-1.61.8
Seeking ratio, delayed vs. immediate footshock1.11.31.7-1.11.3-1.11.01.0-1.01.3-1.1
Distance traveled before self-admin1.01.11.11.1-1.01.0-1.1-1.11.1-1.01.0
Distance traveled after self-admin2.22.42.61.6-1.41.6-1.6-1.61.6-1.41.6
Extensor digitorum longus weight12.950.652.77.3-7.17.1-7.1-7.17.1-7.17.1
Bone: elastic displacement0.50.60.7-0.80.7-0.80.80.9-0.90.7-0.8
Bone: elastic work0.30.30.4-0.60.5-0.60.60.7-0.70.5-0.6
Bone: endosteal estimation0.10.30.30.5-0.40.5-0.6-0.50.5-0.40.5
Bone: endosteal perimeter0.10.10.20.4-0.30.4-0.4-0.40.4-0.30.4
Epididymis fat weight2.35.35.5-2.32.3-2.32.32.3-2.32.3-2.3
Delta time in closed arm before/after self-admin2.22.12.4-1.41.4-1.41.41.5-1.51.4-1.4
Delta time in open arm before/after self-admin0.00.00.1-0.20.3-0.20.30.0-0.00.3-0.2
Diff in mean of infusions in LGA sessions2.73.03.41.7-1.81.7-1.7-1.71.7-1.81.7
Delay discount exponential model param0.20.20.4-0.50.6-0.50.40.4-0.40.6-0.5
Extinction: sum of active levers before priming2.82.83.1-1.71.8-1.61.61.7-1.71.7-1.6
Active lever presses in extinction session 60.30.30.4-0.60.5-0.50.70.6-0.60.4-0.6
Bone: final force0.10.20.20.5-0.40.4-0.5-0.40.4-0.40.4
Bone: final moment0.10.10.20.4-0.40.4-0.4-0.30.3-0.40.4
Food consumed during 24 hour testing period0.20.30.4-0.50.6-0.50.50.5-0.50.6-0.5
Glucose0.00.00.0-0.10.1-0.10.20.2-0.20.1-0.1
Heart weight0.00.00.0-0.10.2-0.20.10.1-0.10.1-0.1
Delay discount hyperbolic model param0.60.60.8-0.80.9-0.80.70.7-0.70.9-0.8
Intermittent access intake day 1-15 change2.32.32.9-1.51.7-1.51.41.4-1.41.7-1.4
Intermittent access intake escalation1.51.52.0-1.21.4-1.21.11.1-1.11.4-1.2
Intermittent access intake escalation 20.50.50.8-0.60.9-0.70.60.6-0.60.9-0.6
Intermitt. access day 1 inactive lever presses0.10.10.1-0.30.3-0.30.30.3-0.30.2-0.3
Intermitt. access day 15 inactive lever presses0.00.00.0-0.1-0.2-0.10.10.1-0.1-0.2-0.1
Intermitt. access escalation Index0.60.50.80.7-0.90.7-0.6-0.60.6-0.90.6
Intermittent access day 1 total infusions0.00.00.0-0.20.1-0.20.20.2-0.20.1-0.2
Intermittent access day 15 total infusions1.01.11.3-1.11.1-1.11.01.0-1.01.1-1.1
Intermittent access terminal intake (last 3 days)0.20.30.4-0.50.6-0.50.40.4-0.40.6-0.5
Intermittent access total infusions0.40.50.5-0.70.7-0.70.70.7-0.70.7-0.7
Intermittent access day 1 locomotion0.30.30.4-0.60.6-0.60.60.6-0.60.5-0.6
Intermittent access day 15 total locomotion1.61.82.2-1.31.5-1.31.31.3-1.31.5-1.2
Intermittent access total locomotion0.50.60.7-0.70.8-0.80.70.7-0.70.8-0.7
Intermittent access standard deviation1.41.51.9-1.21.4-1.21.11.1-1.11.4-1.1
Left kidney weight0.30.71.00.9-0.60.8-0.9-1.01.0-0.60.8
Right kidney weight0.10.30.5-0.60.7-0.60.50.5-0.50.7-0.6
Cocaine induced anxiety0.20.20.30.4-0.50.4-0.4-0.40.4-0.50.4
Post-drug Anxiety0.50.50.6-0.70.7-0.70.70.7-0.70.7-0.7
Baseline Anxiety0.90.91.1-0.91.1-0.90.90.9-0.91.1-0.9
Tail length0.92.72.9-1.61.7-1.61.61.7-1.71.7-1.6
Length with tail0.10.20.30.5-0.50.5-0.5-0.50.5-0.50.5
Length without tail3.88.38.62.9-2.92.9-2.9-2.92.9-2.82.9
Times rat made contact with spout0.40.50.5-0.70.7-0.70.70.7-0.70.7-0.7
Lifetime Intake0.40.50.5-0.70.6-0.70.70.7-0.70.6-0.7
Liver weight, left2.23.63.82.0-1.81.9-1.9-1.91.9-1.81.9
Liver weight, right0.71.21.31.1-1.11.1-1.1-1.11.1-1.11.1
Locomotor activity1.52.32.51.6-1.51.5-1.6-1.61.6-1.51.5
Locomotor testing distance0.00.00.00.00.1-0.1-0.00.0-0.00.1-0.0
Locomotor testing rearing0.20.30.4-0.60.6-0.60.50.6-0.60.6-0.6
Locomotion in novel chamber0.10.20.2-0.40.5-0.40.40.4-0.40.5-0.4
Locomotion in novel chamber post-restriction0.70.80.90.9-0.90.9-0.9-0.90.9-0.80.9
Fecal boli incidents, locomotor time 10.80.91.00.9-0.91.0-1.0-1.01.0-0.91.0
Change in fecal boli incidents, locomotor task0.10.10.20.3-0.40.3-0.3-0.30.3-0.40.3
Time >=10cm from walls, locomotor time 10.70.80.9-0.90.7-0.91.00.9-0.90.7-0.9
Bouts of movement, locomotor time 15.35.76.02.5-2.42.4-2.4-2.42.4-2.42.4
Total resting periods, locomotor time 15.15.66.02.5-2.42.4-2.4-2.32.3-2.42.4
Rest time, locomotor task time 13.23.63.92.0-2.01.9-1.9-1.81.8-2.01.9
Distance moved, locomotor task time 13.23.53.8-1.81.9-1.81.91.9-1.91.9-1.8
Vertical activity count, locomotor time 11.21.21.3-1.21.1-1.11.11.1-1.11.1-1.1
Time >=10cm from walls, locomotor time 20.40.40.40.7-0.60.6-0.6-0.60.6-0.60.6
Bouts of movement, locomotor time 23.94.24.62.1-2.02.0-2.1-2.02.0-2.02.0
Total resting periods, locomotor time 24.44.75.12.2-2.22.2-2.2-2.22.2-2.12.1
Rest time, locomotor task time 20.91.11.21.0-1.11.0-1.1-1.01.0-1.11.0
Distance moved, locomotor task time 22.83.33.7-1.81.9-1.81.81.8-1.81.9-1.7
Vertical activity count, locomotor time 20.40.40.5-0.60.6-0.60.70.6-0.60.6-0.6
Light reinforcement 13.46.16.8-2.62.4-2.52.52.5-2.52.3-2.5
Light reinforcement 21.21.72.0-1.41.1-1.31.41.3-1.31.1-1.4
Bone: marrow area0.10.10.20.4-0.30.4-0.4-0.40.4-0.30.4
Bone: maximum diameter0.30.60.70.8-0.70.8-0.8-0.80.8-0.70.8
Bone: maximum force0.20.40.50.7-0.60.6-0.7-0.60.6-0.60.6
Bone: maximum moment0.10.20.30.5-0.50.5-0.5-0.40.4-0.50.5
Mean time between licks in bursts2.02.82.9-1.71.7-1.71.71.7-1.71.7-1.7
Mean num. licks in bursts0.40.40.5-0.70.6-0.70.70.7-0.70.6-0.7
Cd content in liver0.30.30.4-0.60.4-0.60.60.6-0.60.4-0.6
Co content in liver3.94.64.82.2-2.22.2-2.1-2.12.1-2.22.1
Cu content in liver0.60.70.90.8-0.90.8-0.8-0.80.8-0.90.8
Fe content in liver2.12.62.7-1.61.6-1.61.61.6-1.61.6-1.6
K content in liver0.60.60.7-0.80.7-0.80.80.8-0.80.7-0.8
Mg content in liver1.21.31.4-1.21.1-1.11.11.1-1.11.1-1.1
Mn content in liver2.12.42.5-1.61.6-1.51.51.5-1.51.6-1.5
Na content in liver0.70.70.80.8-0.90.8-0.8-0.80.8-0.90.8
Rb content in liver0.30.30.4-0.60.6-0.60.50.5-0.50.6-0.6
Se content in liver0.91.11.1-1.11.0-1.11.01.0-1.01.0-1.1
Sr content in liver0.50.40.5-0.70.6-0.60.70.7-0.70.6-0.6
Zn content in liver1.01.11.31.1-1.11.1-1.0-1.01.0-1.11.0
Bone: minimum diameter0.10.20.30.5-0.40.5-0.6-0.50.5-0.40.5
Time in familiar zone, hab. session 10.00.00.00.1-0.10.1-0.2-0.20.2-0.10.1
Time in novel zone, hab. session 11.31.31.41.2-1.21.2-1.1-1.11.1-1.21.1
Total zone transitions, hab. session 10.20.30.40.5-0.60.5-0.5-0.50.5-0.60.5
Total locomotion distance, hab. session 10.00.00.0-0.0-0.1-0.00.10.1-0.1-0.1-0.0
Locomotion velocity, hab. session 10.10.10.2-0.40.3-0.30.40.4-0.40.3-0.4
Time in familiar zone, hab. session 22.02.02.11.5-1.41.4-1.4-1.41.4-1.41.4
Time in novel zone, hab. session 20.70.70.8-0.90.8-0.90.90.9-0.90.8-0.9
Total zone transitions, hab. session 21.41.92.01.4-1.41.4-1.3-1.31.3-1.41.3
Total locomotion distance, hab. session 20.20.30.40.6-0.60.6-0.5-0.50.5-0.60.5
Locomotion velocity, hab. session 20.60.80.90.9-0.90.9-0.8-0.80.8-0.90.9
Novel to familiar place preference ratio1.61.61.6-1.31.3-1.31.31.3-1.31.3-1.3
Novelty place preference1.21.21.3-1.11.1-1.11.11.1-1.11.1-1.1
Time in novel zone, NPP test0.60.60.6-0.80.8-0.80.80.8-0.80.8-0.8
Total zone transitions, NPP test0.20.20.3-0.50.4-0.50.50.5-0.50.4-0.5
Total locomotion distance, NPP test2.63.63.8-1.91.8-1.91.91.9-1.91.8-1.9
Locomotion velocity, NPP test2.53.53.8-1.91.8-1.91.91.9-1.91.8-1.9
Intraocular pressure0.50.70.9-0.90.8-0.90.90.9-0.90.8-0.9
Delta distance traveled before/after self-admin2.32.42.81.7-1.41.6-1.6-1.61.6-1.41.6
Delta ambulatory time before/after self-admin2.12.42.61.6-1.41.6-1.5-1.61.6-1.41.6
Parametrial fat weight3.56.97.4-2.72.7-2.72.62.5-2.52.7-2.6
Pavlov. Cond. lever latency0.00.00.00.0-0.00.0-0.00.0-0.0-0.00.0
Pavlov. Cond. magazine entry latency0.00.10.1-0.20.3-0.20.20.2-0.20.3-0.2
Pavlov. Cond. change in total contacts1.01.01.11.0-1.01.0-1.0-1.01.0-1.01.0
Pavlov. Cond. index score0.00.10.10.3-0.20.2-0.2-0.30.3-0.20.2
Pavlov. Cond. latency score0.00.00.00.1-0.10.1-0.1-0.10.1-0.10.1
Pavlov. Cond. lever contacts0.00.00.0-0.10.1-0.10.10.0-0.00.1-0.1
Pavlov. Cond. magazine entry number0.40.50.6-0.80.7-0.70.70.7-0.70.7-0.7
Pavlov. Cond. intertrial magazine entries0.10.10.1-0.30.2-0.30.30.3-0.30.2-0.3
Pavlov. Cond. lever-magazine prob. diff.0.10.20.20.4-0.40.4-0.4-0.40.4-0.40.4
Pavlov. Cond. response bias0.10.10.20.4-0.30.4-0.4-0.40.4-0.30.4
Pavlov. Cond. lever latency0.40.50.5-0.70.7-0.70.70.7-0.70.7-0.7
Pavlov. Cond. magazine entry latency0.10.10.1-0.30.3-0.30.30.3-0.30.3-0.3
Pavlov. Cond. change in total contacts1.62.22.31.5-1.51.5-1.5-1.51.5-1.51.5
Pavlov. Cond. index score0.50.60.70.8-0.80.8-0.8-0.80.8-0.80.8
Pavlov. Cond. latency score0.30.40.40.6-0.60.6-0.6-0.60.6-0.60.6
Pavlov. Cond. lever contacts0.40.50.50.7-0.70.7-0.7-0.70.7-0.70.7
Pavlov. Cond. magazine entry number0.00.10.10.2-0.20.2-0.2-0.20.2-0.20.2
Pavlov. Cond. intertrial magazine entries6.28.18.6-2.92.9-2.82.82.8-2.82.9-2.8
Pavlov. Cond. lever-magazine prob. diff.0.60.80.80.9-0.90.9-0.9-0.90.9-0.90.9
Pavlov. Cond. response bias0.40.60.60.8-0.80.8-0.8-0.80.8-0.80.8
Time in closed arm before self-admin1.92.22.41.5-1.41.4-1.5-1.61.6-1.41.5
Time in closed arm after self-admin0.60.60.70.8-0.80.8-0.8-0.80.8-0.80.8
Time in open arm before self-admin0.10.10.20.4-0.40.4-0.4-0.20.2-0.40.3
Time in open arm after self-admin0.10.10.2-0.30.4-0.30.40.3-0.30.4-0.3
Bone: periosteal estimation0.00.10.10.3-0.20.2-0.3-0.30.3-0.20.2
Bone: periosteal perimeter0.00.00.00.1-0.00.1-0.2-0.10.1-0.00.1
Bone: post-yield work0.20.20.2-0.50.5-0.50.40.4-0.40.5-0.5
Progressive ratio test 1 active lever presses0.20.20.30.5-0.60.5-0.5-0.50.5-0.60.4
Progressive ratio test 1 breakpoint0.10.10.20.3-0.40.3-0.3-0.30.3-0.40.3
Progressive ratio test 1 inactive lever presses1.41.61.9-1.41.0-1.31.31.3-1.31.0-1.3
Progressive ratio test 2 active lever presses0.20.20.2-0.50.5-0.50.50.5-0.50.4-0.5
Progressive ratio test 2 breakpoint0.30.30.3-0.50.5-0.50.50.5-0.50.5-0.5
Progressive ratio test 2 inactive lever presses0.40.40.5-0.70.5-0.70.70.7-0.70.5-0.7
Incentive Sensitization - Responses1.01.11.2-1.01.1-1.01.01.0-1.01.1-1.0
Incentive Sensitization - Breakpoint1.51.51.7-1.21.3-1.21.21.2-1.21.3-1.2
Sum of active levers in priming session hrs 5-60.10.10.1-0.20.1-0.20.20.4-0.40.1-0.2
Progressive ratio0.10.10.2-0.30.3-0.40.40.4-0.40.3-0.4
Food seeking constrained by brief footshock1.31.61.81.3-1.31.3-1.3-1.31.3-1.31.3
Seeking ratio, punishment vs. effort0.91.11.21.1-1.01.1-1.1-1.11.1-1.01.1
Retroperitoneal fat weight0.20.71.1-0.91.0-0.90.70.7-0.71.0-0.8
Reaction time number correct0.50.70.90.9-0.70.9-0.9-0.90.9-0.70.9
Reaction time mean minus median0.10.20.30.4-0.50.4-0.4-0.40.4-0.50.4
Reaction time mean minus median AUC0.10.10.20.3-0.50.4-0.3-0.40.4-0.50.4
Reaction time num false alarms0.00.00.10.20.00.2-0.2-0.30.30.00.2
Reaction time num false alarms AUC0.00.00.0-0.00.2-0.0-0.0-0.10.10.2-0.0
Reaction time trials correct on left0.50.70.90.9-0.70.9-0.9-0.90.9-0.70.9
Reaction time trials on left0.40.50.60.8-0.60.8-0.7-0.80.8-0.60.8
Reaction time mean0.20.30.40.4-0.70.5-0.4-0.40.4-0.70.5
Reaction time mean AUC0.40.50.70.6-0.80.7-0.6-0.60.6-0.80.7
Median of all reaction times0.10.10.20.2-0.40.3-0.2-0.20.2-0.40.3
Reaction time omissions2.23.03.4-1.91.6-1.71.81.8-1.81.6-1.8
Reaction time false alarm rate0.10.20.3-0.40.5-0.40.40.4-0.40.5-0.4
Reaction time premature initiation rate1.52.02.41.4-1.51.4-1.4-1.31.3-1.51.3
Reaction time premature initiations2.13.03.31.7-1.81.7-1.7-1.71.7-1.81.7
Std. dev. reaction times0.20.20.30.4-0.60.5-0.4-0.40.4-0.60.4
Reaction time trials completed0.40.50.60.8-0.60.8-0.7-0.80.8-0.60.8
Reaction time trials AUC0.30.50.60.8-0.60.7-0.7-0.80.8-0.50.7
Run reversals in cocaine runway, females4.14.04.2-2.02.0-2.02.02.1-2.12.0-2.0
Run reversals in cocaine runway, males2.52.42.51.6-1.61.6-1.5-1.51.5-1.51.5
Latency to leave start box in cocaine runway0.60.60.70.7-0.80.8-0.8-0.80.8-0.80.8
Latency to leave start box in cocaine runway, F1.41.61.71.2-1.21.3-1.2-1.31.3-1.21.2
Latency to leave start box in cocaine runway, M1.31.21.3-1.11.1-1.11.11.1-1.11.1-1.1
Std. dev. time between licks in bursts1.41.71.8-1.31.3-1.31.31.3-1.31.2-1.3
Total sessions with >9 infusions0.00.00.0-0.1-0.0-0.10.10.1-0.1-0.1-0.2
Short access day 1 total inactive lever presses0.50.50.6-0.80.6-0.80.80.8-0.80.6-0.8
Short access day 10 total inactive lever presses0.30.40.4-0.70.5-0.60.60.6-0.60.5-0.6
Short access day 1 total infusions0.10.10.20.3-0.50.3-0.3-0.30.3-0.50.3
Short access day 10 total infusions0.00.00.0-0.20.0-0.20.20.2-0.2-0.0-0.2
Short access total infusions0.20.20.2-0.50.3-0.50.50.5-0.50.3-0.5
Short access day 1 locomotion0.20.20.30.5-0.50.4-0.5-0.50.5-0.50.4
Short access day 10 total locomotion0.50.60.7-0.80.7-0.80.80.8-0.80.7-0.8
Short access total locomotion0.70.70.8-0.90.7-0.90.90.9-0.90.7-0.9
One hour access (0.3 mA shock)0.30.30.5-0.60.7-0.60.50.5-0.50.7-0.5
Compulsive drug intake0.00.00.00.10.10.1-0.1-0.10.10.10.1
One hour access (shock baseline)0.00.00.0-0.0-0.1-0.0-0.0-0.00.0-0.1-0.0
Social response proportion0.10.10.10.3-0.20.3-0.3-0.30.3-0.20.3
Social responses1.11.51.6-1.21.2-1.21.21.2-1.21.2-1.2
Social time0.30.50.5-0.70.7-0.70.60.7-0.70.7-0.7
Soleus weight1.02.83.11.8-1.61.7-1.7-1.71.7-1.61.7
Bone: stiffness0.60.91.01.0-0.90.9-1.0-0.90.9-0.90.9
Tibialis anterior weight8.228.129.55.4-5.35.3-5.3-5.35.3-5.25.3
Time to tail flick, vehicle, before self-admin0.80.81.0-1.00.9-0.90.90.8-0.80.9-1.0
Time to tail flick, vehicle, after self-admin2.02.12.41.5-1.51.4-1.4-1.41.4-1.51.4
Time to tail flick, test, before self-admin0.90.91.0-1.00.9-1.01.01.0-1.00.9-1.0
Time to tail flick, test, after self-admin3.33.43.7-1.91.9-1.91.81.8-1.81.8-1.9
Delta time to tail flick, vehicle, before/after SA0.40.40.40.7-0.60.6-0.6-0.50.5-0.60.6
Delta time to tail flick, test, before/after SA0.30.20.3-0.50.5-0.50.50.4-0.40.5-0.5
Tibia length1.23.53.8-1.92.0-1.91.81.8-1.81.9-1.8
Ambulatory time before self-admin0.60.70.80.8-0.90.8-0.8-0.80.8-0.90.8
Ambulatory time after self-admin3.64.04.32.1-1.92.0-2.0-2.02.0-1.92.0
Bone: tissue strength0.10.10.1-0.30.3-0.30.20.3-0.30.4-0.3
Total heroin consumption0.30.40.40.6-0.60.6-0.6-0.70.7-0.60.6
Bone: trabecular number2.74.24.6-2.12.2-2.12.02.0-2.02.1-2.0
Bone: trabecular spacing2.43.13.41.8-1.81.8-1.8-1.71.7-1.71.8
Bone: trabecular thickness1.31.51.6-1.31.2-1.21.21.2-1.21.2-1.2
Bone: trabecular tissue density1.41.92.11.4-1.51.4-1.4-1.31.3-1.41.4
Water consumed over 24 hours1.31.61.71.3-1.21.3-1.3-1.31.3-1.21.3
Number of responses in last shaping day0.00.00.10.0-0.30.1-0.0-0.00.0-0.30.0