Batf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	gene expression	Batf2	0.48	0.17	6.5e-05	0.18	0.16	0.14	0.17	1.1e-03	1.6e-03	3.2e-03	1.2e-03
2	Brain	isoform ratio	XM_006230953.4	0.03	0.02	3.6e-03	0	0.02	-0	0	1.6e-01	9.5e-03	6.9e-01	1.8e-01
3	Liver	gene expression	Batf2	0.06	0.03	2.2e-04	0.02	0.02	0.01	0	2.2e-03	5.2e-03	2.7e-02	1.2e-01
4	Liver	isoform ratio	XM_006230953.4	0.06	0.04	3.1e-03	-0	0	0	0	6.2e-01	2.7e-01	2.1e-01	2.3e-01
5	Adipose	gene expression	Batf2	0.13	0.07	6.4e-06	0.01	0	0.01	0.01	1.7e-02	7.6e-02	1.6e-02	1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.2	0.4	0.9	0.5	0.2	-0.7	0.9	0.6
Area under the delay curve	0.2	0.2	0.5	-0.2	0.2	-0.6	0.4	-0.7
BMI with tail	1.3	4.3	8.4	2.9	2.2	-1.9	2.0	0.2
BMI without tail	0.8	1.6	3.3	1.6	1.8	-0.8	0.9	-0.7
Body weight	1.5	6.2	17.9	4.2	3.5	0.6	-0.7	0.2
Weight adjusted by age	1.2	1.4	2.3	1.5	1.1	1.2	-1.2	0.9
Bone surface	1.6	2.7	6.8	2.6	1.3	0.3	-0.4	2.2
Bone volume	0.8	1.4	4.8	1.4	0.2	-0.3	0.2	2.2
Breakpoint value in progressive ratio session	2.0	2.1	3.9	2.0	1.2	1.4	-1.4	1.1
Number of licking bursts	0.2	0.3	0.5	0.7	0.2	0.6	-0.4	0.5
Context. condit. distance diff. score	1.4	1.6	2.9	-1.7	-1.0	-1.4	1.3	-0.8
Locomotion velocity, session 1	0.3	0.3	1.1	0.2	0.7	-0.2	0.0	-1.0
Locomotion distance, session 1	0.4	0.5	1.0	0.7	1.0	-0.5	0.7	-0.7
Locomotion velocity, session 2	1.3	1.5	3.9	2.0	1.7	0.7	-0.3	-0.1
Locomotion distance, session 2	0.5	0.7	1.5	1.0	1.2	0.1	0.3	-0.8
Locomotion velocity, session 3	1.3	1.5	3.7	-0.4	-0.2	-1.9	1.8	-0.6
Locomotion distance, session 3	0.1	0.1	0.3	-0.2	-0.0	-0.5	0.4	-0.3
Stereotopy head waving bouts, day 3	1.9	2.3	5.4	-0.8	-0.3	-2.3	2.1	-0.9
Stereotopy head waving duration, day 3	1.0	1.1	2.1	-0.9	-0.7	-1.5	1.4	-0.3
Locomotion velocity, session 7	1.3	1.5	3.6	-0.8	-0.7	-1.6	1.9	-0.1
Locomotion distance, session 7	0.6	0.7	1.3	-0.4	0.3	-0.9	1.1	-1.2
Stereotopy head waving bouts, day 7	0.5	0.6	1.3	-0.3	-0.9	-0.5	0.5	1.1
Stereotopy head waving duration, day 7	0.5	0.6	1.5	1.1	0.3	0.5	-0.4	1.2
Locomotion velocity, session 8	0.9	1.0	2.5	1.1	1.6	0.2	-0.4	-1.1
Locomotion distance, session 8	0.7	1.0	2.6	-0.6	-0.3	-1.4	1.6	-0.3
Degree of sensitization distance	0.6	0.6	1.5	-0.3	0.1	-1.0	1.2	-0.6
Degree of sensitization stereotypy	0.6	0.7	2.3	0.7	-0.2	0.4	-0.4	1.5
Conditioned locomotion	0.8	1.0	2.0	1.4	1.4	0.6	-0.7	-0.2
Cocaine response after cond. corrected	1.5	1.7	2.3	-1.5	-0.5	-1.5	1.3	-1.4
Cocaine response after cond. not corrected	1.4	1.6	2.5	-1.3	-0.4	-1.6	1.3	-1.3
Cocaine response before conditioning	0.5	0.6	0.9	0.9	0.3	0.7	-0.7	1.0
Saline control response	2.4	3.2	6.6	2.6	2.5	1.2	-1.1	-0.5
Bone: connectivity density	0.6	1.0	3.0	1.7	1.2	0.2	0.1	0.8
Bone: cortical apparent density	0.6	0.8	1.7	0.8	0.7	1.1	-1.3	-0.3
Bone: cortical area	0.3	0.5	1.2	0.8	0.4	0.3	-0.4	1.1
Bone: cortical porosity	0.0	0.0	0.1	0.1	0.1	0.0	0.2	0.1
Bone: cortical porosity	0.2	0.2	0.6	0.8	0.7	0.4	-0.2	0.0
Bone: cortical thickness	2.3	3.8	4.9	2.2	2.2	2.1	-2.1	-0.5
Bone: cortical thickness	1.2	1.3	2.2	0.8	1.5	0.7	-1.2	-1.4
Bone: cortical tissue density	0.8	1.0	2.1	0.9	0.8	1.3	-1.5	-0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.3	0.5	0.2	-0.1	-0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.1	0.2	0.6	-0.6	-0.1
Condit. Reinf. active responses	0.1	0.1	0.4	0.0	-0.1	-0.3	0.6	0.2
Condit. Reinf. inactive responses	0.7	0.8	2.1	-0.3	-0.6	-1.1	1.5	0.5
Incentive salience index mean	0.1	0.2	0.3	0.5	0.6	-0.2	0.4	-0.2
Condit. Reinf. lever presses	0.2	0.2	0.4	0.6	0.3	-0.4	0.6	0.5
Condit. Reinf. active minus inactive responses	0.5	0.6	1.2	-0.5	-1.0	-0.5	0.3	1.1
Condit. Reinf. active-inactive response ratio	2.0	2.1	3.1	-0.9	-1.8	-1.3	1.3	1.7
Condit. Reinf. active responses	0.1	0.1	0.5	0.1	-0.3	-0.0	-0.2	0.7
Condit. Reinf. inactive responses	0.5	0.6	1.0	0.6	1.0	0.6	-0.7	-0.8
Condit. Reinf. lever presses	1.2	1.7	3.3	1.8	0.6	0.8	-1.0	1.8
Condit. Reinf. lever reinforcers received	0.2	0.3	0.9	0.5	-0.1	0.4	-0.6	1.0
Conditioned reinforcement - actives	0.9	0.9	2.9	-0.5	-1.2	-0.1	0.1	1.7
Conditioned reinforcement - inactives	4.3	4.8	10.6	-2.9	-3.3	-1.1	1.0	1.6
Conditioned locomotion	4.5	5.4	11.4	-3.3	-3.4	-1.5	1.3	0.7
Patch foraging indifference point 0 sec	0.0	0.0	0.1	-0.1	-0.3	0.1	0.2	0.1
Patch foraging indifference point AUC	2.5	2.9	5.3	2.3	1.3	1.5	-1.9	1.3
Delay disc. indifference point, 0s delay	1.0	1.0	2.3	-0.4	0.2	-1.5	1.0	-1.3
Delay disc. indifference point, 16s delay	0.6	0.6	1.2	-1.1	-1.1	-0.6	0.6	0.3
Delay disc. indifference point, 2s delay	0.2	0.2	0.6	-0.3	-0.2	-0.8	0.7	-0.0
Delay disc. indifference point, 24s delay	0.4	0.4	1.4	-0.3	0.5	0.0	-0.3	-1.2
Delay disc. indifference point, 4s delay	0.7	0.7	2.2	-0.4	0.5	-0.6	0.7	-1.5
Delay disc. indifference point, 8s delay	0.4	0.4	1.5	-0.1	0.6	-0.5	0.3	-1.2
Indifference point function ln k	5.9	8.2	14.6	-3.8	-2.0	-2.8	2.9	-2.4
Indifference point function log k	5.9	8.2	14.6	-3.8	-2.0	-2.8	2.9	-2.4
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	-0.0	0.0	0.3	-0.1	-0.3
Patch foraging total patch changes 12 sec	2.9	3.7	7.5	2.7	1.9	1.9	-1.8	0.8
Patch foraging total patch changes 18 sec	0.4	0.5	1.2	1.1	0.4	0.4	-0.3	0.9
Patch foraging total patch changes 24 sec	1.9	2.4	4.3	2.1	1.5	1.6	-1.6	0.4
Patch foraging total patch changes 6 sec	0.5	0.7	1.9	1.4	1.2	0.5	-0.3	-0.3
Patch foraging time to switch 0 sec	0.6	1.0	2.8	1.7	0.7	-0.1	0.3	1.2
Patch foraging water rate 0 sec	1.4	2.2	6.5	-2.5	-1.9	-0.5	0.5	-0.7
Patch foraging water rate 12 sec	3.5	5.4	14.4	-3.8	-2.0	-1.2	1.2	-2.4
Patch foraging water rate 18 sec	2.0	2.7	5.3	-2.3	-1.0	-1.4	1.4	-1.9
Patch foraging water rate 24 sec	1.9	2.6	6.3	-2.5	-1.4	-1.3	1.2	-1.4
Patch foraging water rate 6 sec	2.0	2.9	6.0	-2.5	-1.0	-1.1	1.2	-2.3
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.1	-0.2	-0.1	0.1	0.2	-0.4
Distance traveled before self-admin	0.6	0.7	1.8	0.9	0.1	0.5	-0.6	1.3
Distance traveled after self-admin	0.5	0.5	1.0	0.5	-0.1	1.0	-0.7	0.9
Extensor digitorum longus weight	3.6	14.2	35.3	5.9	4.9	2.3	-2.5	0.5
Bone: elastic displacement	0.8	0.9	3.0	-1.3	-0.1	-0.1	-0.0	-1.7
Bone: elastic work	1.1	1.4	2.8	0.8	1.7	0.5	-0.8	-1.6
Bone: endosteal estimation	2.2	4.8	9.1	-1.6	-1.6	-3.0	3.0	0.8
Bone: endosteal perimeter	2.8	5.9	9.1	-1.7	-2.3	-3.0	2.9	1.8
Epididymis fat weight	2.4	5.5	7.3	-2.6	-2.6	-2.7	2.5	0.6
Delta time in closed arm before/after self-admin	1.6	1.5	5.6	0.0	1.2	-0.6	0.4	-2.4
Delta time in open arm before/after self-admin	1.3	1.3	3.5	0.3	-0.6	1.2	-0.9	1.9
Diff in mean of infusions in LGA sessions	0.5	0.5	1.1	0.5	0.5	1.0	-1.0	0.3
Delay discount exponential model param	0.2	0.2	0.5	0.2	-0.3	0.4	-0.3	0.7
Extinction: sum of active levers before priming	2.4	2.4	5.2	2.3	1.6	1.4	-1.1	0.8
Active lever presses in extinction session 6	2.3	2.2	3.2	1.6	0.9	1.8	-1.4	1.6
Bone: final force	1.1	1.8	5.0	2.2	1.6	0.5	-0.6	0.9
Bone: final moment	0.9	1.5	4.2	2.1	1.5	0.4	-0.5	0.8
Food consumed during 24 hour testing period	0.6	0.7	1.1	0.4	-0.3	1.1	-1.1	0.9
Glucose	2.3	3.5	5.7	-1.7	-1.7	-2.4	2.4	0.1
Heart weight	2.6	3.7	6.7	-2.6	-1.6	-2.0	2.0	-1.0
Delay discount hyperbolic model param	0.2	0.2	0.5	0.1	-0.3	0.5	-0.3	0.7
Intermittent access intake day 1-15 change	0.9	0.9	1.8	-0.8	-1.3	0.3	-0.2	1.3
Intermittent access intake escalation	0.7	0.7	1.6	-0.8	-1.2	0.1	-0.0	1.2
Intermittent access intake escalation 2	0.8	0.8	2.0	-0.4	-0.9	0.7	-0.8	1.4
Intermitt. access day 1 inactive lever presses	1.6	1.8	3.3	-1.8	-1.8	-1.1	0.9	0.6
Intermitt. access day 15 inactive lever presses	2.6	2.8	5.8	-1.9	-2.4	-1.2	1.0	1.5
Intermitt. access escalation Index	2.6	2.3	3.3	-1.8	-1.0	-1.4	1.8	-1.4
Intermittent access day 1 total infusions	7.2	8.4	13.8	-2.6	-2.8	-3.7	3.6	0.5
Intermittent access day 15 total infusions	7.8	8.8	13.9	-3.3	-3.7	-3.0	2.9	1.4
Intermittent access terminal intake (last 3 days)	7.1	7.8	11.3	-2.7	-3.4	-3.0	2.8	1.8
Intermittent access total infusions	6.4	7.1	9.7	-2.4	-3.0	-3.1	3.0	1.3
Intermittent access day 1 locomotion	5.9	6.2	11.3	-2.1	-1.8	-3.4	3.4	-0.7
Intermittent access day 15 total locomotion	4.8	5.2	8.6	-2.5	-2.9	-2.2	2.1	1.2
Intermittent access total locomotion	8.3	9.5	13.4	-2.8	-3.4	-3.7	3.6	1.4
Intermittent access standard deviation	1.0	1.0	2.3	-1.2	-1.5	-0.4	0.3	1.0
Left kidney weight	0.5	1.5	2.8	-1.4	-1.7	-0.9	0.9	0.9
Right kidney weight	0.4	1.1	3.3	-0.6	-1.4	-0.3	0.0	1.8
Cocaine induced anxiety	0.2	0.2	1.0	0.0	-0.3	-0.0	0.1	1.0
Post-drug Anxiety	1.1	1.2	2.9	1.2	0.5	0.8	-0.8	1.7
Baseline Anxiety	1.6	1.7	2.7	1.6	1.6	1.3	-1.2	-0.2
Tail length	1.1	3.3	5.0	1.4	2.0	2.2	-2.2	-0.9
Length with tail	1.5	5.6	9.2	3.0	2.7	2.3	-2.5	0.0
Length without tail	1.1	2.4	6.0	2.4	1.7	1.0	-1.2	0.5
Times rat made contact with spout	0.7	0.8	1.1	0.8	1.0	1.0	-0.8	-0.7
Lifetime Intake	5.5	6.3	9.6	-2.3	-2.6	-3.1	3.0	0.8
Liver weight, left	0.2	0.3	1.0	-0.2	-0.2	-1.0	0.5	0.0
Liver weight, right	0.5	0.8	1.7	-0.2	0.4	-1.3	1.1	-1.0
Locomotor activity	1.0	1.6	3.4	-1.8	-0.6	-0.7	0.7	-1.9
Locomotor testing distance	1.7	2.8	7.2	-2.2	-0.5	-1.0	0.9	-2.7
Locomotor testing rearing	1.4	2.1	4.3	-2.1	-0.6	-1.0	0.7	-2.1
Locomotion in novel chamber	4.0	5.0	9.4	-2.5	-3.1	-1.9	1.8	1.5
Locomotion in novel chamber post-restriction	1.9	2.3	4.1	-2.0	-2.0	-1.2	1.4	0.3
Fecal boli incidents, locomotor time 1	0.9	1.0	4.0	0.2	-0.8	0.1	-0.2	2.0
Change in fecal boli incidents, locomotor task	1.5	1.5	4.1	-0.1	0.9	-1.2	1.0	-2.0
Time >=10cm from walls, locomotor time 1	3.0	3.1	4.8	-0.7	-1.6	-2.2	2.2	1.6
Bouts of movement, locomotor time 1	3.4	3.7	8.6	1.3	0.8	2.9	-2.6	0.8
Total resting periods, locomotor time 1	2.6	2.9	7.0	1.1	0.4	2.6	-2.2	1.1
Rest time, locomotor task time 1	0.5	0.6	1.3	-1.1	-1.2	-0.3	0.5	0.1
Distance moved, locomotor task time 1	0.1	0.2	0.4	0.3	0.2	-0.5	0.6	-0.1
Vertical activity count, locomotor time 1	1.0	1.0	1.9	-1.4	-1.0	-1.1	0.9	-0.3
Time >=10cm from walls, locomotor time 2	0.5	0.5	1.9	0.2	-0.5	0.5	-0.3	1.4
Bouts of movement, locomotor time 2	0.8	0.8	2.0	0.6	0.5	1.1	-1.4	0.2
Total resting periods, locomotor time 2	0.4	0.4	1.2	0.4	0.3	0.7	-1.1	0.2
Rest time, locomotor task time 2	2.1	2.4	4.4	-1.7	-1.5	-2.1	1.5	-0.2
Distance moved, locomotor task time 2	1.1	1.2	2.2	1.2	1.0	1.5	-1.2	0.2
Vertical activity count, locomotor time 2	0.4	0.5	1.2	-0.1	0.5	0.7	-0.5	-1.1
Light reinforcement 1	0.1	0.1	0.2	-0.3	-0.2	0.5	-0.4	-0.3
Light reinforcement 2	1.3	1.7	3.7	-1.1	-1.9	-0.4	0.5	1.8
Bone: marrow area	2.3	4.9	9.6	-1.6	-1.6	-3.1	3.1	0.7
Bone: maximum diameter	0.5	0.9	3.8	0.3	-0.5	-0.4	0.3	1.9
Bone: maximum force	1.2	2.0	5.8	2.4	1.3	-0.3	0.1	1.6
Bone: maximum moment	1.0	1.7	4.7	2.2	1.2	-0.3	0.1	1.4
Mean time between licks in bursts	1.1	1.6	3.7	1.0	1.8	0.3	-0.4	-1.9
Mean num. licks in bursts	0.2	0.2	0.7	-0.5	0.1	-0.1	-0.0	-0.8
Cd content in liver	1.0	1.1	2.6	-1.2	-1.6	-0.4	0.0	1.2
Co content in liver	1.0	1.2	3.2	-1.3	-0.1	0.5	-0.8	-1.8
Cu content in liver	0.2	0.3	0.5	0.5	0.4	0.7	-0.6	0.1
Fe content in liver	0.1	0.1	0.3	0.3	0.1	0.1	0.1	0.6
K content in liver	0.7	0.7	1.7	1.3	1.1	-0.6	0.6	-0.1
Mg content in liver	0.4	0.4	1.1	0.3	0.1	-1.0	1.0	-0.1
Mn content in liver	1.4	1.6	3.3	1.8	0.8	0.9	-1.0	1.4
Na content in liver	0.5	0.6	1.3	1.1	0.7	0.5	-0.6	0.7
Rb content in liver	1.3	1.6	3.0	-1.5	-1.1	-1.7	1.2	-0.5
Se content in liver	0.9	1.1	4.3	-0.1	-1.1	0.3	0.2	2.1
Sr content in liver	3.3	3.0	4.4	1.9	1.4	2.1	-2.1	0.8
Zn content in liver	0.7	0.8	1.4	1.2	0.8	0.9	-0.8	0.4
Bone: minimum diameter	1.8	3.3	6.1	-1.4	-1.5	-2.4	2.5	0.7
Time in familiar zone, hab. session 1	0.5	0.5	0.9	-0.6	-0.5	-0.9	0.9	-0.0
Time in novel zone, hab. session 1	0.3	0.3	1.3	-0.3	0.3	0.1	-0.3	-1.1
Total zone transitions, hab. session 1	0.4	0.5	0.9	1.0	0.7	0.8	-0.6	0.2
Total locomotion distance, hab. session 1	0.4	0.6	1.4	-0.6	-0.6	-0.9	1.2	0.0
Locomotion velocity, hab. session 1	0.1	0.1	0.5	-0.2	-0.2	-0.3	0.7	0.1
Time in familiar zone, hab. session 2	0.7	0.7	2.6	-0.1	0.9	-0.1	0.2	-1.6
Time in novel zone, hab. session 2	0.2	0.2	0.7	0.3	-0.3	0.1	-0.3	0.8
Total zone transitions, hab. session 2	0.6	0.7	1.8	1.3	1.2	-0.2	0.4	-0.2
Total locomotion distance, hab. session 2	0.6	0.8	2.3	-0.0	0.2	-1.2	1.5	-0.6
Locomotion velocity, hab. session 2	0.8	1.0	3.0	-0.2	-0.2	-1.4	1.7	-0.2
Novel to familiar place preference ratio	1.2	1.2	3.7	1.1	-0.0	0.7	-0.9	1.9
Novelty place preference	0.9	0.9	3.0	0.7	-0.3	0.6	-0.7	1.7
Time in novel zone, NPP test	0.6	0.6	2.0	0.6	-0.2	0.4	-0.6	1.4
Total zone transitions, NPP test	1.0	1.4	3.8	2.0	1.5	0.7	-0.5	0.3
Total locomotion distance, NPP test	0.2	0.3	0.6	0.2	0.3	-0.7	0.8	-0.3
Locomotion velocity, NPP test	0.1	0.1	0.3	0.3	0.2	-0.3	0.5	-0.1
Intraocular pressure	1.1	1.6	3.2	-1.1	-1.8	0.6	-0.4	1.7
Delta distance traveled before/after self-admin	0.2	0.2	0.8	-0.3	0.2	0.2	-0.0	-0.9
Delta ambulatory time before/after self-admin	0.3	0.4	1.5	-0.2	0.5	0.4	-0.1	-1.2
Parametrial fat weight	2.7	5.3	9.0	-2.2	-2.2	-3.0	2.7	0.5
Pavlov. Cond. lever latency	0.1	0.1	0.4	-0.6	-0.4	0.2	-0.3	-0.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	0.5	0.1	-0.1	0.1	0.6
Pavlov. Cond. change in total contacts	0.5	0.5	2.2	0.2	-0.6	0.2	-0.2	1.5
Pavlov. Cond. index score	0.2	0.2	0.5	0.5	0.1	0.4	-0.3	0.7
Pavlov. Cond. latency score	0.0	0.1	0.1	0.3	0.1	0.0	0.1	0.4
Pavlov. Cond. lever contacts	0.0	0.1	0.2	0.1	0.2	-0.3	0.4	-0.1
Pavlov. Cond. magazine entry number	0.6	0.7	1.4	-0.6	0.1	-1.0	1.0	-1.2
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.2	-1.0	-1.1	0.5	-0.2	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.6	0.7	0.2	0.5	-0.4	0.8
Pavlov. Cond. response bias	0.2	0.2	0.6	0.3	-0.1	0.5	-0.5	0.7
Pavlov. Cond. lever latency	0.3	0.5	1.6	-0.8	-0.1	-0.2	0.2	-1.3
Pavlov. Cond. magazine entry latency	1.9	2.2	4.4	2.1	1.5	1.5	-1.2	0.7
Pavlov. Cond. change in total contacts	1.7	2.3	6.2	1.6	0.1	1.2	-1.2	2.5
Pavlov. Cond. index score	1.4	1.8	3.4	1.8	0.7	1.1	-1.0	1.7
Pavlov. Cond. latency score	1.0	1.3	2.6	1.6	0.6	0.8	-0.7	1.6
Pavlov. Cond. lever contacts	0.5	0.7	1.6	0.9	0.1	0.7	-0.7	1.2
Pavlov. Cond. magazine entry number	3.8	4.6	8.8	-3.0	-1.8	-2.1	2.0	-1.5
Pavlov. Cond. intertrial magazine entries	0.7	1.0	1.8	-1.4	-1.1	-0.9	1.0	-0.1
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.1	4.1	2.0	1.0	1.3	-1.1	1.6
Pavlov. Cond. response bias	1.2	1.7	2.8	1.7	0.7	1.2	-1.2	1.5
Time in closed arm before self-admin	0.4	0.4	1.8	0.2	-0.5	0.1	0.1	1.4
Time in closed arm after self-admin	0.5	0.5	1.1	-0.2	0.2	-0.7	0.8	-1.0
Time in open arm before self-admin	1.7	1.9	7.7	-0.8	0.7	-0.7	0.3	-2.8
Time in open arm after self-admin	0.4	0.4	1.0	-0.4	-0.1	1.0	-0.9	-0.3
Bone: periosteal estimation	0.8	1.6	2.8	-0.4	-0.9	-1.7	1.6	1.4
Bone: periosteal perimeter	0.4	0.7	2.0	0.1	-0.5	-0.9	0.8	1.4
Bone: post-yield work	2.8	3.8	7.2	0.6	-1.1	-2.2	2.3	2.7
Progressive ratio test 1 active lever presses	2.2	2.3	4.2	-1.9	-2.1	-1.3	1.2	0.5
Progressive ratio test 1 breakpoint	1.8	1.9	3.7	-1.8	-1.9	-1.1	1.1	0.4
Progressive ratio test 1 inactive lever presses	0.7	0.8	1.7	-1.3	-1.0	-0.7	0.7	-0.4
Progressive ratio test 2 active lever presses	4.3	4.7	8.5	-2.4	-2.9	-1.9	1.8	1.5
Progressive ratio test 2 breakpoint	4.2	4.7	9.2	-2.7	-3.0	-1.7	1.7	1.1
Progressive ratio test 2 inactive lever presses	7.3	8.4	15.4	-3.4	-3.9	-2.5	2.4	1.7
Incentive Sensitization - Responses	0.9	0.9	1.7	-0.8	-1.3	-0.7	0.7	1.2
Incentive Sensitization - Breakpoint	1.1	1.2	2.2	-1.0	-1.5	-0.8	0.8	1.2
Sum of active levers in priming session hrs 5-6	3.2	3.1	6.5	1.2	-0.1	2.0	-1.8	2.6
Progressive ratio	0.8	0.9	2.7	1.6	1.0	0.2	0.4	0.8
Food seeking constrained by brief footshock	0.5	0.6	1.6	0.3	1.0	0.4	-0.1	-1.3
Seeking ratio, punishment vs. effort	1.0	1.3	3.6	-1.6	-0.4	-0.3	0.0	-1.9
Retroperitoneal fat weight	4.4	14.3	20.9	-4.6	-4.2	-4.1	3.9	0.3
Reaction time number correct	0.2	0.3	0.5	0.6	0.7	0.5	-0.6	-0.1
Reaction time mean minus median	1.9	2.5	4.9	2.2	0.9	0.8	-1.3	2.1
Reaction time mean minus median AUC	1.2	1.5	2.8	1.7	0.7	0.8	-1.2	1.4
Reaction time num false alarms	0.9	1.2	5.0	-0.6	0.6	-0.4	0.6	-2.2
Reaction time num false alarms AUC	0.8	1.1	4.4	0.0	1.1	0.0	0.1	-2.1
Reaction time trials correct on left	0.2	0.3	0.5	0.6	0.7	0.5	-0.6	-0.1
Reaction time trials on left	0.3	0.4	0.7	0.7	0.8	0.6	-0.7	-0.1
Reaction time mean	0.4	0.6	2.0	0.4	-0.5	0.2	-0.7	1.4
Reaction time mean AUC	0.5	0.6	2.3	0.3	-0.7	0.1	-0.6	1.5
Median of all reaction times	0.3	0.4	1.3	-0.1	-0.8	-0.1	-0.4	1.1
Reaction time omissions	0.7	1.0	1.9	1.4	0.9	0.8	-1.3	0.6
Reaction time false alarm rate	0.7	1.0	3.5	-0.6	0.4	-0.5	0.7	-1.9
Reaction time premature initiation rate	2.7	3.7	7.5	2.1	2.7	1.0	-1.5	-1.8
Reaction time premature initiations	3.9	5.6	10.1	2.6	3.2	1.8	-2.2	-1.6
Std. dev. reaction times	0.8	1.2	2.8	1.2	0.2	0.6	-1.1	1.7
Reaction time trials completed	0.3	0.4	0.7	0.7	0.8	0.6	-0.7	-0.1
Reaction time trials AUC	0.2	0.2	0.5	0.5	0.7	0.3	-0.4	-0.3
Run reversals in cocaine runway, females	1.7	1.7	3.8	0.6	1.3	-1.1	1.2	-2.0
Run reversals in cocaine runway, males	0.1	0.1	0.3	-0.5	-0.2	-0.1	-0.2	-0.3
Latency to leave start box in cocaine runway	0.4	0.4	0.9	-0.2	-0.4	-0.9	1.0	0.3
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.0	-0.2	0.1	0.0	0.5
Latency to leave start box in cocaine runway, M	0.6	0.5	1.3	-0.2	-0.1	-1.1	1.1	-0.1
Std. dev. time between licks in bursts	0.8	1.0	3.9	-0.2	0.9	-0.4	0.3	-2.0
Total sessions with >9 infusions	3.0	3.3	6.2	-1.5	-1.2	-2.5	2.5	-0.6
Short access day 1 total inactive lever presses	2.9	3.3	5.2	-2.3	-2.0	-1.9	1.9	-0.4
Short access day 10 total inactive lever presses	2.1	2.4	4.9	-2.2	-1.3	-1.3	1.2	-1.5
Short access day 1 total infusions	3.5	3.8	6.8	-1.8	-1.8	-2.4	2.6	-0.1
Short access day 10 total infusions	4.1	4.6	9.4	-1.4	-1.6	-3.0	3.1	0.3
Short access total infusions	2.9	3.3	6.7	-1.3	-1.2	-2.6	2.6	-0.2
Short access day 1 locomotion	3.5	3.8	6.9	-1.8	-1.4	-2.5	2.6	-0.5
Short access day 10 total locomotion	2.3	2.5	5.0	-1.5	-1.3	-1.9	2.2	-0.4
Short access total locomotion	2.4	2.5	5.0	-1.3	-1.1	-2.1	2.2	-0.6
One hour access (0.3 mA shock)	7.7	9.0	14.9	-3.7	-3.9	-2.9	2.7	0.9
Compulsive drug intake	4.5	4.5	6.4	1.7	2.5	2.2	-2.2	-2.0
One hour access (shock baseline)	8.9	10.4	19.0	-3.5	-4.4	-2.8	2.6	2.5
Social response proportion	0.6	0.6	1.1	1.0	0.6	0.8	-0.7	0.8
Social responses	0.3	0.4	1.0	0.5	0.6	1.0	-0.7	0.0
Social time	0.3	0.4	0.8	0.6	0.9	0.6	-0.8	-0.3
Soleus weight	2.4	7.0	13.5	-3.7	-3.0	-2.4	2.6	-0.6
Bone: stiffness	1.1	1.7	4.4	2.1	0.9	0.2	-0.2	1.8
Tibialis anterior weight	6.0	20.5	44.7	6.7	5.2	3.8	-3.8	1.1
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.6	0.8	0.4	-0.5	0.4	0.6
Time to tail flick, vehicle, after self-admin	1.0	1.1	2.9	1.2	1.7	-0.2	0.5	-1.0
Time to tail flick, test, before self-admin	2.1	2.0	4.1	-0.8	-0.3	-2.0	2.0	-1.1
Time to tail flick, test, after self-admin	0.1	0.1	0.3	0.1	0.2	0.6	-0.3	0.0
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.1	0.6	1.1	0.0	0.1	-0.9
Delta time to tail flick, test, before/after SA	3.8	3.4	8.1	1.1	0.7	2.8	-2.5	1.0
Tibia length	1.2	3.3	9.5	1.8	0.0	1.4	-1.3	3.1
Ambulatory time before self-admin	0.9	1.0	3.7	0.8	-0.4	0.5	-0.5	1.9
Ambulatory time after self-admin	0.5	0.5	1.7	-0.3	-1.0	0.2	0.2	1.3
Bone: tissue strength	0.2	0.2	0.6	0.2	-0.3	0.2	-0.0	0.8
Total heroin consumption	3.8	4.5	7.9	2.8	2.2	2.3	-2.0	0.6
Bone: trabecular number	0.4	0.6	2.1	0.6	-0.1	-0.3	0.5	1.5
Bone: trabecular spacing	0.3	0.5	2.0	-0.4	0.3	0.0	-0.0	-1.4
Bone: trabecular thickness	0.7	0.8	1.1	-1.0	-1.1	-0.8	1.0	0.5
Bone: trabecular tissue density	1.8	2.5	5.6	-2.4	-2.1	-1.1	1.0	0.2
Water consumed over 24 hours	1.3	1.6	2.9	1.1	1.1	1.6	-1.7	-0.2
Number of responses in last shaping day	0.6	0.6	1.6	-1.3	-0.7	-0.4	0.4	-0.8