Batf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Batf2	0.04	0.03	3.5e-04	0.02	0.04	0.03	0.03	5.5e-03	8.3e-05	2.1e-04	1.6e-04
2	Eye	gene expression	Batf2	0.52	0.18	2.9e-05	0.22	0.19	0.14	0.2	3.0e-04	8.2e-04	3.1e-03	5.5e-04
3	Liver	alternative polyA	XM_039094948.2	0.08	0.04	1.2e-05	0.02	0.02	0.02	0.02	5.9e-03	2.1e-03	1.4e-03	2.6e-03
4	Liver	gene expression	Batf2	0.09	0.04	1.8e-08	0.02	0.04	0.04	0.04	9.8e-04	1.3e-05	2.2e-05	6.3e-05
5	IC	gene expression	Batf2	0.09	0.07	7.5e-03	0.06	0.04	0.04	0.04	1.9e-03	6.2e-03	6.4e-03	7.0e-03
6	Brain	gene expression	Batf2	0.18	0.1	2.5e-08	0.1	0.09	0.09	0.09	3.2e-09	1.6e-08	8.1e-09	8.1e-09
7	pVTA	gene expression	Batf2	0.06	0.04	3.8e-05	0.03	0.06	0.04	0.05	1.3e-03	1.1e-05	3.7e-04	1.3e-04
8	Adipose	gene expression	Batf2	0.25	0.1	1.2e-11	0.05	0.06	0.06	0.05	1.3e-06	8.3e-07	8.6e-07	2.7e-06
9	NAcc	gene expression	Batf2	0.03	0.02	3.5e-04	0.03	0.02	0.01	0.02	1.7e-05	9.9e-04	4.5e-03	2.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.2	0.4	1.2	-0.6	0.9	-0.3	-0.2	-1.0	-1.1	0.1	0.1	-0.8
Area under the delay curve	0.1	0.1	0.7	-0.0	0.0	-0.2	0.6	-0.1	-0.1	-0.1	-0.5	-0.8
BMI with tail	0.7	2.3	5.3	-1.6	2.3	-0.2	-0.6	-2.3	-2.2	-0.2	-0.4	-1.6
BMI without tail	0.1	0.8	2.0	-1.2	1.4	0.4	-0.2	-0.6	-0.6	-0.9	-1.1	-0.7
Body weight	1.1	4.8	14.0	-3.1	3.7	1.9	-2.5	0.0	0.1	-2.1	-1.9	1.1
Weight adjusted by age	0.6	1.7	2.9	-1.6	1.7	1.5	-1.7	1.0	1.0	-0.9	-0.7	1.4
Bone surface	1.5	2.9	9.0	-2.7	3.0	1.2	-2.6	-0.3	-0.3	-0.7	-0.3	0.6
Bone volume	0.5	1.1	2.9	-1.5	1.7	0.1	-1.4	-0.9	-1.0	0.3	0.6	-0.4
Breakpoint value in progressive ratio session	1.2	2.2	4.9	-2.2	2.0	1.5	-2.0	1.0	1.1	-1.0	-0.9	0.8
Number of licking bursts	0.1	0.2	0.5	-0.7	0.6	0.4	-0.7	0.2	0.2	-0.1	-0.0	0.2
Context. condit. distance diff. score	1.3	1.6	3.0	1.6	-1.6	-1.4	1.7	-0.9	-0.9	0.8	0.5	-1.2
Locomotion velocity, session 1	0.2	0.2	0.7	0.1	0.2	0.4	0.0	0.3	0.3	-0.8	-0.9	0.6
Locomotion distance, session 1	0.2	0.2	0.5	-0.4	0.7	0.1	0.1	-0.4	-0.4	-0.5	-0.7	-0.2
Locomotion velocity, session 2	1.1	1.3	3.5	-1.6	1.9	1.0	-1.3	0.2	0.2	-1.2	-1.1	0.6
Locomotion distance, session 2	0.3	0.4	0.9	-0.7	0.9	0.5	-0.2	-0.0	-0.0	-0.8	-1.0	0.0
Locomotion velocity, session 3	1.0	1.2	2.4	1.0	-0.5	-1.3	1.2	-1.6	-1.6	0.5	0.4	-1.0
Locomotion distance, session 3	0.0	0.0	0.1	0.3	-0.2	-0.2	0.3	-0.2	-0.2	-0.0	-0.1	-0.1
Stereotopy head waving bouts, day 3	1.4	1.6	2.9	1.4	-0.9	-1.5	1.6	-1.7	-1.7	0.5	0.4	-1.0
Stereotopy head waving duration, day 3	1.0	1.2	1.7	1.2	-0.9	-1.3	1.3	-1.3	-1.3	0.9	0.8	-1.0
Locomotion velocity, session 7	1.6	1.7	3.1	0.9	-0.7	-1.5	1.4	-1.6	-1.6	1.0	0.8	-1.8
Locomotion distance, session 7	0.2	0.3	0.7	0.4	-0.2	-0.5	0.8	-0.5	-0.5	-0.2	-0.4	-0.6
Stereotopy head waving bouts, day 7	0.5	0.6	1.1	0.1	-0.1	-0.6	0.1	-0.8	-0.8	1.0	1.0	-1.0
Stereotopy head waving duration, day 7	0.3	0.4	1.0	-1.0	1.0	0.3	-0.8	-0.2	-0.2	0.3	0.4	-0.4
Locomotion velocity, session 8	1.1	1.4	2.7	-0.8	1.1	1.1	-0.9	0.8	0.8	-1.7	-1.5	1.5
Locomotion distance, session 8	0.7	1.1	2.1	0.9	-0.5	-1.2	1.0	-1.4	-1.4	0.6	0.5	-1.1
Degree of sensitization distance	0.3	0.3	0.8	0.4	-0.1	-0.6	0.6	-0.9	-0.9	0.1	-0.0	-0.6
Degree of sensitization stereotypy	0.3	0.3	0.7	-0.8	0.7	0.2	-0.7	-0.2	-0.2	0.6	0.7	-0.5
Conditioned locomotion	1.0	1.2	1.6	-1.3	1.3	1.1	-1.3	0.7	0.7	-1.2	-1.0	1.1
Cocaine response after cond. corrected	0.7	1.1	2.6	1.6	-1.5	-1.1	1.6	-0.7	-0.7	0.2	0.0	-0.5
Cocaine response after cond. not corrected	0.6	0.9	1.9	1.4	-1.3	-1.0	1.4	-0.8	-0.8	0.2	0.1	-0.4
Cocaine response before conditioning	0.4	0.5	1.3	-1.1	1.1	0.8	-1.2	0.4	0.4	-0.1	0.0	0.3
Saline control response	3.1	4.3	6.4	-2.3	2.5	2.2	-2.2	1.4	1.4	-2.3	-2.1	2.0
Bone: connectivity density	0.7	1.2	4.1	-1.7	2.0	0.7	-1.4	-0.3	-0.4	-0.7	-0.6	0.0
Bone: cortical apparent density	0.4	0.6	1.7	-0.6	0.2	1.0	-0.5	1.3	1.3	-0.5	-0.5	0.5
Bone: cortical area	0.3	0.5	1.4	-1.0	1.2	0.5	-1.2	0.0	-0.1	-0.3	-0.1	0.6
Bone: cortical porosity	0.1	0.1	0.2	-0.4	0.5	0.2	-0.2	-0.0	0.0	-0.1	-0.1	-0.1
Bone: cortical porosity	0.3	0.3	0.7	-0.8	0.9	0.5	-0.6	0.2	0.2	-0.5	-0.5	0.2
Bone: cortical thickness	3.6	6.0	7.5	-2.4	2.3	2.7	-2.4	2.4	2.3	-2.5	-2.3	2.5
Bone: cortical thickness	1.5	1.9	3.4	-0.7	0.7	1.4	-0.7	1.5	1.6	-1.8	-1.9	1.5
Bone: cortical tissue density	0.6	0.9	2.2	-0.8	0.4	1.2	-0.7	1.5	1.5	-0.7	-0.7	0.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.5	0.4	0.3	-0.1	0.2	0.2	-0.3	-0.4	-0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	-0.4	0.2	0.5	-0.1	0.7	0.7	-0.2	-0.4	-0.0
Condit. Reinf. active responses	0.1	0.2	0.4	-0.0	0.1	-0.4	0.2	-0.6	-0.6	0.3	0.3	-0.6
Condit. Reinf. inactive responses	1.0	1.2	2.8	0.7	-0.4	-1.3	0.7	-1.7	-1.7	0.9	1.0	-1.0
Incentive salience index mean	0.1	0.1	0.3	-0.5	0.5	0.0	-0.0	-0.3	-0.3	-0.2	-0.3	-0.4
Condit. Reinf. lever presses	0.2	0.3	0.7	-0.5	0.7	-0.2	-0.4	-0.8	-0.8	0.1	0.2	-0.3
Condit. Reinf. active minus inactive responses	0.3	0.4	1.2	0.2	-0.3	-0.6	0.1	-0.6	-0.6	0.9	1.1	-0.6
Condit. Reinf. active-inactive response ratio	1.6	2.6	4.4	1.0	-0.9	-1.8	0.7	-1.9	-1.9	1.9	2.1	-1.4
Condit. Reinf. active responses	0.1	0.1	0.3	-0.5	0.3	0.2	-0.4	0.0	0.1	0.4	0.4	-0.4
Condit. Reinf. inactive responses	0.7	1.0	1.5	-1.1	0.9	1.2	-0.6	1.2	1.1	-1.0	-1.2	0.4
Condit. Reinf. lever presses	0.7	1.1	3.1	-1.7	1.6	0.8	-1.8	0.2	0.2	-0.1	0.2	0.5
Condit. Reinf. lever reinforcers received	0.2	0.3	0.8	-0.9	0.7	0.5	-0.8	0.4	0.4	0.1	0.2	-0.0
Conditioned reinforcement - actives	0.2	0.6	2.7	-0.1	0.1	-0.3	-0.9	-0.7	-0.7	1.1	1.6	0.2
Conditioned reinforcement - inactives	1.3	3.6	7.3	1.8	-2.0	-1.8	1.2	-1.5	-1.5	2.5	2.7	-1.5
Conditioned locomotion	4.7	7.0	10.7	3.2	-3.3	-2.5	2.5	-1.8	-1.8	3.1	3.1	-2.0
Patch foraging indifference point 0 sec	0.0	0.0	0.2	0.2	-0.1	-0.1	0.2	-0.1	-0.3	0.2	0.2	-0.4
Patch foraging indifference point AUC	1.0	2.5	5.2	-2.1	1.9	1.9	-2.3	1.3	1.2	-0.8	-0.5	1.3
Delay disc. indifference point, 0s delay	0.4	0.5	1.1	0.5	-0.3	-0.6	1.1	-0.8	-0.8	0.1	-0.3	-1.0
Delay disc. indifference point, 16s delay	0.6	0.9	1.9	0.7	-0.9	-1.0	1.0	-0.6	-0.6	1.1	0.8	-1.4
Delay disc. indifference point, 2s delay	0.3	0.4	0.7	0.4	-0.2	-0.7	0.5	-0.9	-0.9	0.5	0.4	-0.8
Delay disc. indifference point, 24s delay	0.2	0.3	0.8	0.0	-0.1	0.3	0.2	0.8	0.8	-0.6	-0.9	0.4
Delay disc. indifference point, 4s delay	0.2	0.2	0.7	0.3	-0.2	-0.2	0.8	-0.2	-0.2	-0.4	-0.8	-0.6
Delay disc. indifference point, 8s delay	0.1	0.1	0.6	0.0	0.0	0.0	0.5	0.2	0.2	-0.5	-0.8	-0.4
Indifference point function ln k	2.6	7.7	15.5	3.9	-3.7	-3.2	3.9	-1.9	-2.0	1.5	1.0	-2.1
Indifference point function log k	2.6	7.7	15.5	3.9	-3.7	-3.2	3.9	-1.9	-2.0	1.5	1.0	-2.1
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	0.1	0.0	0.2	0.1	0.3	0.2	-0.3	-0.3	0.2
Patch foraging total patch changes 12 sec	3.1	4.1	7.2	-2.7	2.7	2.4	-2.4	1.6	1.4	-1.6	-1.4	1.4
Patch foraging total patch changes 18 sec	0.2	0.4	1.2	-1.0	1.1	0.6	-0.9	0.2	-0.1	-0.2	-0.1	0.1
Patch foraging total patch changes 24 sec	0.8	2.8	4.0	-1.8	1.9	2.0	-2.0	1.5	1.3	-1.5	-1.2	1.8
Patch foraging total patch changes 6 sec	0.5	0.9	1.5	-1.1	1.2	1.0	-0.9	0.6	0.5	-1.1	-1.1	0.7
Patch foraging time to switch 0 sec	0.2	0.9	3.0	-1.5	1.7	0.3	-0.9	-0.9	-0.9	0.2	0.2	-0.8
Patch foraging water rate 0 sec	0.7	2.5	7.9	2.6	-2.8	-1.7	1.8	-0.0	-0.1	0.9	0.9	0.0
Patch foraging water rate 12 sec	1.2	5.0	14.5	3.8	-3.7	-2.3	3.1	-0.3	-0.3	0.8	0.6	-0.2
Patch foraging water rate 18 sec	0.9	2.1	5.7	2.4	-2.3	-1.5	2.1	-0.7	-0.7	0.3	0.1	-0.3
Patch foraging water rate 24 sec	1.9	2.7	7.1	2.7	-2.7	-1.9	2.1	-0.6	-0.7	0.7	0.7	-0.2
Patch foraging water rate 6 sec	1.9	2.8	8.1	2.8	-2.8	-1.8	2.3	-0.2	-0.3	0.1	-0.0	0.2
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	1.4	0.3	-0.5	-0.4	0.8	-0.2	-0.2	0.5	0.2	-1.2
Distance traveled before self-admin	0.2	0.4	1.0	-1.0	1.0	0.2	-0.9	-0.2	-0.3	0.4	0.5	-0.4
Distance traveled after self-admin	0.2	0.3	0.7	-0.8	0.6	0.7	-0.7	0.8	0.7	-0.1	-0.1	0.2
Extensor digitorum longus weight	4.4	17.7	33.8	-5.5	5.8	4.6	-5.0	2.3	2.3	-4.0	-3.6	3.2
Bone: elastic displacement	0.5	0.6	1.1	1.1	-1.0	-0.0	0.7	0.7	0.6	-0.7	-0.7	0.9
Bone: elastic work	1.7	2.2	4.1	-0.9	1.1	1.5	-0.8	1.4	1.3	-2.0	-2.0	1.7
Bone: endosteal estimation	2.2	5.4	10.5	1.8	-1.2	-2.8	1.8	-3.2	-3.2	1.9	1.9	-2.2
Bone: endosteal perimeter	2.9	7.1	12.5	1.9	-1.4	-3.1	1.7	-3.5	-3.5	2.7	2.8	-2.5
Epididymis fat weight	2.4	12.0	17.2	3.7	-3.5	-4.1	2.9	-3.5	-3.5	3.6	3.7	-2.6
Delta time in closed arm before/after self-admin	0.9	0.9	3.0	-0.1	0.4	0.7	0.2	0.6	0.7	-1.6	-1.7	0.9
Delta time in open arm before/after self-admin	0.3	0.4	1.1	-0.8	0.5	0.2	-1.1	0.1	0.1	0.6	0.9	0.1
Diff in mean of infusions in LGA sessions	0.4	0.7	0.9	-0.9	0.8	0.9	-0.9	0.7	0.8	-0.9	-0.8	0.8
Delay discount exponential model param	0.1	0.1	0.4	0.1	-0.1	-0.0	-0.4	-0.1	-0.1	0.2	0.6	0.6
Extinction: sum of active levers before priming	0.8	1.2	3.0	-1.7	1.7	1.2	-1.3	0.3	0.4	-0.7	-0.7	0.1
Active lever presses in extinction session 6	1.8	1.8	4.9	-1.9	2.0	1.2	-2.2	0.4	0.3	-0.7	-0.2	1.2
Bone: final force	1.0	1.7	4.5	-1.8	2.1	1.1	-1.9	0.2	0.2	-1.0	-0.7	1.0
Bone: final moment	1.0	1.6	4.2	-1.7	2.1	1.1	-1.8	0.2	0.1	-1.0	-0.7	1.0
Food consumed during 24 hour testing period	0.1	0.3	0.6	-0.4	0.2	0.5	-0.8	0.7	0.7	0.1	0.3	0.6
Glucose	3.5	5.5	7.4	2.4	-2.2	-2.7	2.7	-2.6	-2.5	1.9	1.5	-2.4
Heart weight	2.1	3.3	5.8	1.8	-1.3	-2.1	2.3	-2.4	-2.4	0.6	0.1	-1.9
Delay discount hyperbolic model param	0.1	0.1	0.5	0.1	-0.1	0.1	-0.4	0.1	0.1	0.1	0.4	0.7
Intermittent access intake day 1-15 change	0.3	1.4	3.4	1.2	-1.4	-1.1	0.6	-0.8	-0.8	1.7	1.9	-0.7
Intermittent access intake escalation	0.2	1.2	3.5	1.0	-1.2	-0.9	0.3	-0.8	-0.8	1.6	1.9	-0.5
Intermittent access intake escalation 2	0.6	1.1	3.1	0.9	-1.1	-0.9	0.3	-0.6	-0.6	1.5	1.8	-0.5
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	0.2	-0.3	0.4	0.2	0.3	0.3	0.4	0.4	-0.3
Intermitt. access day 15 inactive lever presses	0.6	3.2	5.5	1.6	-1.6	-1.6	1.2	-1.7	-1.7	2.3	2.4	-1.8
Intermitt. access escalation Index	0.9	2.8	4.9	2.0	-2.0	-2.1	2.2	-1.1	-1.1	1.3	0.9	-1.8
Intermittent access day 1 total infusions	2.9	8.6	13.8	2.3	-1.9	-3.2	2.3	-3.7	-3.7	2.9	2.8	-3.1
Intermittent access day 15 total infusions	4.1	10.0	14.3	3.0	-2.8	-3.3	2.2	-3.4	-3.4	3.6	3.8	-2.7
Intermittent access terminal intake (last 3 days)	6.1	10.6	14.9	2.8	-2.6	-3.5	2.1	-3.8	-3.8	3.7	3.9	-2.8
Intermittent access total infusions	7.8	9.3	13.9	2.6	-2.3	-3.3	2.1	-3.7	-3.7	3.2	3.3	-2.8
Intermittent access day 1 locomotion	2.8	5.2	7.8	1.9	-1.7	-2.3	1.9	-2.8	-2.8	2.3	2.2	-2.4
Intermittent access day 15 total locomotion	2.3	8.8	14.2	2.5	-2.5	-3.0	1.9	-3.1	-3.1	3.7	3.8	-2.8
Intermittent access total locomotion	12.2	14.6	19.7	3.1	-3.0	-4.1	2.6	-4.3	-4.3	4.4	4.4	-3.7
Intermittent access standard deviation	0.3	1.4	2.5	1.4	-1.4	-0.9	0.9	-1.0	-1.0	1.4	1.6	-0.6
Left kidney weight	0.5	3.9	5.3	1.8	-1.4	-2.3	1.7	-2.2	-2.3	2.0	1.8	-2.0
Right kidney weight	0.2	1.4	2.0	1.3	-1.0	-1.4	0.9	-1.3	-1.3	1.3	1.3	-0.7
Cocaine induced anxiety	0.0	0.1	0.2	-0.3	0.2	0.2	-0.4	-0.0	-0.0	0.4	0.5	-0.1
Post-drug Anxiety	0.4	0.4	0.9	-0.9	0.9	0.7	-1.0	0.3	0.3	-0.3	-0.2	0.5
Baseline Anxiety	0.5	0.9	1.6	-0.5	0.6	0.9	-0.4	0.9	0.9	-1.3	-1.3	1.0
Tail length	0.7	4.0	5.5	-1.5	1.5	2.4	-1.5	2.2	2.2	-2.2	-2.1	2.2
Length with tail	2.0	8.6	10.5	-2.9	3.2	3.2	-2.9	2.5	2.4	-3.2	-2.9	3.1
Length without tail	1.3	6.8	9.3	-2.4	2.8	2.6	-2.5	2.1	2.1	-3.0	-2.7	3.0
Times rat made contact with spout	0.8	0.9	1.4	-1.0	0.8	1.1	-0.5	1.1	1.1	-1.0	-1.2	0.4
Lifetime Intake	5.6	6.9	10.9	2.3	-1.9	-2.8	2.0	-3.3	-3.3	2.6	2.6	-2.4
Liver weight, left	0.6	1.0	2.3	1.5	-1.2	-1.2	1.3	-0.9	-0.9	0.3	0.3	-0.3
Liver weight, right	1.4	2.5	6.0	2.4	-2.0	-1.7	2.3	-1.4	-1.3	0.4	0.1	-0.7
Locomotor activity	0.8	1.3	4.1	2.0	-1.9	-0.9	1.7	-0.1	-0.1	-0.0	-0.2	0.2
Locomotor testing distance	0.7	1.7	5.3	2.3	-2.1	-1.0	1.9	0.1	-0.0	-0.2	-0.4	0.4
Locomotor testing rearing	0.4	1.4	4.3	2.1	-2.0	-0.8	1.9	0.0	-0.0	-0.0	-0.3	-0.0
Locomotion in novel chamber	4.8	6.5	8.3	2.9	-2.8	-2.9	2.3	-2.4	-2.4	2.6	2.6	-1.9
Locomotion in novel chamber post-restriction	1.3	3.9	4.9	2.1	-2.2	-2.2	1.8	-1.6	-1.6	2.2	2.1	-1.8
Fecal boli incidents, locomotor time 1	0.2	0.5	1.6	-0.3	0.2	-0.2	-0.6	-0.7	-0.7	1.0	1.3	-0.7
Change in fecal boli incidents, locomotor task	0.2	0.2	0.6	0.5	-0.3	-0.2	0.7	-0.2	-0.2	-0.7	-0.8	0.2
Time >=10cm from walls, locomotor time 1	3.5	4.4	8.3	1.1	-0.6	-2.0	1.0	-2.9	-2.9	2.3	2.3	-2.4
Bouts of movement, locomotor time 1	2.6	3.4	6.7	-2.1	1.2	2.2	-1.8	2.6	2.6	-0.8	-0.7	1.4
Total resting periods, locomotor time 1	1.7	2.0	3.9	-1.7	0.9	1.7	-1.5	2.0	2.0	-0.4	-0.2	0.9
Rest time, locomotor task time 1	0.8	1.2	2.2	1.4	-1.5	-1.2	0.9	-0.8	-0.8	1.2	1.4	-0.5
Distance moved, locomotor task time 1	0.1	0.1	0.4	-0.2	0.5	-0.3	0.2	-0.5	-0.5	-0.1	-0.3	-0.6
Vertical activity count, locomotor time 1	0.1	0.8	1.4	1.2	-1.0	-1.1	1.2	-0.7	-0.7	0.6	0.4	-0.7
Time >=10cm from walls, locomotor time 2	0.1	0.3	0.8	-0.5	0.4	0.1	-0.6	-0.2	-0.2	0.8	0.9	-0.5
Bouts of movement, locomotor time 2	0.3	0.8	1.8	-1.2	0.6	1.0	-0.8	1.4	1.4	-0.4	-0.5	0.2
Total resting periods, locomotor time 2	0.1	0.3	0.9	-0.8	0.3	0.6	-0.5	0.9	0.9	-0.1	-0.2	-0.2
Rest time, locomotor task time 2	1.7	2.8	3.8	1.9	-1.8	-1.8	1.8	-1.6	-1.6	1.5	1.5	-1.4
Distance moved, locomotor task time 2	1.4	1.8	2.2	-1.4	1.4	1.5	-1.4	1.4	1.4	-1.1	-1.1	1.2
Vertical activity count, locomotor time 2	0.3	0.8	1.7	0.0	0.0	0.7	-0.2	1.1	1.1	-1.0	-1.0	1.3
Light reinforcement 1	0.0	0.1	0.3	0.1	-0.1	0.3	0.1	0.5	0.3	-0.1	-0.1	0.2
Light reinforcement 2	0.7	1.7	4.2	1.0	-0.8	-1.3	0.4	-1.3	-1.3	1.8	2.0	-0.8
Bone: marrow area	2.3	5.7	10.8	1.9	-1.2	-2.9	1.9	-3.3	-3.3	2.0	1.9	-2.3
Bone: maximum diameter	0.3	0.6	1.1	-0.3	0.6	-0.5	-0.8	-1.0	-1.0	0.6	1.1	0.1
Bone: maximum force	0.9	1.8	6.0	-2.1	2.4	0.7	-2.0	-0.6	-0.6	-0.6	-0.2	0.4
Bone: maximum moment	0.9	1.6	5.5	-2.0	2.3	0.7	-1.8	-0.6	-0.6	-0.6	-0.3	0.4
Mean time between licks in bursts	0.2	1.2	3.3	-0.4	0.5	1.0	-0.2	0.9	0.9	-1.7	-1.8	1.1
Mean num. licks in bursts	0.0	0.1	0.3	0.4	-0.5	0.0	0.6	0.3	0.3	-0.2	-0.4	-0.1
Cd content in liver	1.4	1.6	3.2	1.0	-1.2	-1.3	0.7	-0.9	-0.9	1.8	1.8	-1.3
Co content in liver	0.7	0.9	1.8	0.9	-1.2	0.3	0.8	1.4	1.4	-0.6	-0.8	0.6
Cu content in liver	0.1	0.1	0.6	-0.1	-0.1	-0.0	0.3	0.0	0.0	0.4	0.1	-0.8
Fe content in liver	0.2	0.2	0.8	-0.1	0.4	0.1	-0.5	-0.1	-0.1	-0.5	-0.5	0.9
K content in liver	0.2	0.2	0.5	-0.4	0.6	0.0	-0.1	-0.4	-0.4	-0.6	-0.7	-0.1
Mg content in liver	0.4	0.4	1.1	0.7	-0.6	-0.8	1.0	-0.6	-0.6	0.1	-0.2	-0.7
Mn content in liver	1.7	1.9	4.4	-2.0	2.0	1.2	-2.1	0.7	0.7	-0.9	-0.5	1.2
Na content in liver	0.5	0.6	1.2	-0.6	0.8	0.8	-1.0	0.5	0.5	-0.8	-0.4	1.1
Rb content in liver	1.3	1.5	3.6	1.7	-1.7	-1.4	1.9	-0.6	-0.6	0.6	0.3	-1.0
Se content in liver	0.4	0.5	1.1	0.3	-0.4	-0.8	0.1	-0.7	-0.7	1.1	1.1	-0.5
Sr content in liver	2.9	2.5	4.2	-1.9	1.7	1.8	-2.1	1.5	1.5	-1.2	-0.9	1.5
Zn content in liver	0.4	0.4	0.7	-0.8	0.8	0.7	-0.4	0.6	0.6	-0.6	-0.8	0.1
Bone: minimum diameter	2.3	4.4	7.3	1.4	-1.0	-2.4	1.7	-2.7	-2.7	1.9	1.7	-2.5
Time in familiar zone, hab. session 1	0.5	0.6	0.8	0.6	-0.6	-0.9	0.8	-0.9	-0.9	0.6	0.5	-0.9
Time in novel zone, hab. session 1	0.3	0.3	0.7	0.4	-0.3	0.3	0.2	0.7	0.7	-0.7	-0.7	0.9
Total zone transitions, hab. session 1	0.3	0.5	1.1	-1.1	1.0	0.9	-0.7	0.5	0.5	-0.4	-0.4	0.1
Total locomotion distance, hab. session 1	0.6	0.9	1.4	0.8	-0.6	-1.0	1.0	-1.2	-1.2	0.8	0.7	-1.1
Locomotion velocity, hab. session 1	0.2	0.3	0.5	0.2	-0.1	-0.4	0.4	-0.7	-0.7	0.5	0.4	-0.7
Time in familiar zone, hab. session 2	0.4	0.5	1.6	0.3	-0.1	0.2	0.2	0.4	0.4	-1.2	-1.3	0.8
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.4	0.3	0.1	-0.1	-0.0	-0.0	0.6	0.5	-0.6
Total zone transitions, hab. session 2	0.4	0.5	1.9	-1.1	1.4	0.4	-0.4	-0.4	-0.4	-0.5	-0.7	-0.4
Total locomotion distance, hab. session 2	0.5	0.7	1.6	0.3	0.0	-0.8	0.9	-1.3	-1.3	0.3	0.0	-1.1
Locomotion velocity, hab. session 2	0.9	1.2	2.6	0.6	-0.2	-1.1	1.0	-1.6	-1.6	0.7	0.5	-1.4
Novel to familiar place preference ratio	0.5	0.7	1.8	-1.3	1.2	0.7	-1.3	0.1	0.1	0.4	0.7	-0.0
Novelty place preference	0.3	0.4	0.9	-1.0	0.8	0.4	-0.9	0.0	0.0	0.6	0.8	-0.3
Time in novel zone, NPP test	0.2	0.3	0.7	-0.8	0.7	0.4	-0.8	0.0	0.0	0.5	0.6	-0.2
Total zone transitions, NPP test	1.0	1.4	3.9	-1.8	2.0	1.2	-1.4	0.3	0.3	-1.0	-0.9	0.5
Total locomotion distance, NPP test	0.1	0.2	0.4	-0.0	0.3	-0.3	0.4	-0.7	-0.7	0.0	-0.1	-0.6
Locomotion velocity, NPP test	0.1	0.1	0.3	-0.2	0.3	-0.1	0.2	-0.5	-0.5	0.1	0.0	-0.6
Intraocular pressure	0.6	0.9	3.1	0.9	-1.2	-0.6	0.2	-0.3	-0.3	1.5	1.8	-0.2
Delta distance traveled before/after self-admin	0.5	0.5	1.1	0.3	-0.4	0.6	0.3	1.0	1.0	-0.8	-0.9	0.7
Delta ambulatory time before/after self-admin	0.4	0.6	1.3	0.1	-0.2	0.7	0.2	1.1	1.1	-1.0	-1.0	0.9
Parametrial fat weight	4.2	9.8	12.9	3.1	-3.0	-3.6	3.0	-3.2	-3.2	3.1	2.9	-3.1
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.5	-0.6	-0.1	0.3	0.3	0.3	0.2	0.2	0.2
Pavlov. Cond. magazine entry latency	0.2	0.2	0.6	-0.7	0.6	-0.0	-0.3	-0.3	-0.3	0.3	0.2	-0.8
Pavlov. Cond. change in total contacts	0.3	0.4	0.9	-0.6	0.4	-0.1	-0.3	-0.3	-0.3	0.9	0.9	-1.0
Pavlov. Cond. index score	0.1	0.1	0.5	-0.7	0.6	0.3	-0.5	0.1	0.1	0.1	0.1	-0.2
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.5	0.4	0.1	-0.3	-0.1	-0.1	0.1	0.0	-0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.2	0.3	-0.2	0.0	-0.4	-0.4	-0.0	-0.1	-0.4
Pavlov. Cond. magazine entry number	0.3	0.4	1.0	1.0	-0.7	-0.6	0.9	-0.6	-0.6	-0.1	-0.2	-0.0
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.8	0.6	-0.9	-0.5	0.4	0.0	0.0	0.8	0.8	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.8	-0.9	0.8	0.4	-0.6	0.1	0.1	0.1	0.1	-0.3
Pavlov. Cond. response bias	0.2	0.2	0.5	-0.7	0.6	0.4	-0.6	0.3	0.3	0.1	0.1	-0.1
Pavlov. Cond. lever latency	0.3	0.4	1.3	0.8	-0.9	-0.3	1.1	0.1	0.1	-0.1	-0.5	-0.4
Pavlov. Cond. magazine entry latency	2.1	3.0	7.0	-2.6	2.6	1.9	-2.2	1.0	1.0	-1.1	-1.1	0.8
Pavlov. Cond. change in total contacts	0.5	1.2	3.3	-1.8	1.6	0.8	-1.7	0.1	0.2	0.4	0.7	-0.1
Pavlov. Cond. index score	0.9	1.5	4.0	-2.0	2.0	1.1	-1.9	0.3	0.3	-0.3	0.0	0.4
Pavlov. Cond. latency score	0.7	1.1	3.3	-1.8	1.8	0.9	-1.7	0.1	0.1	-0.1	0.2	0.3
Pavlov. Cond. lever contacts	0.3	0.4	1.3	-0.9	0.9	0.3	-1.1	-0.0	-0.0	0.1	0.4	0.4
Pavlov. Cond. magazine entry number	4.0	5.2	11.7	3.4	-3.2	-2.5	3.1	-1.5	-1.5	1.3	1.0	-1.2
Pavlov. Cond. intertrial magazine entries	0.5	1.1	1.8	1.3	-1.3	-1.2	1.1	-0.8	-0.8	0.9	0.9	-0.6
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.9	5.0	-2.2	2.2	1.3	-2.1	0.5	0.5	-0.4	-0.1	0.5
Pavlov. Cond. response bias	1.0	1.4	3.5	-1.9	1.9	1.1	-1.8	0.4	0.4	-0.4	-0.1	0.6
Time in closed arm before self-admin	0.6	1.1	2.2	0.5	-0.6	-1.0	0.4	-1.2	-1.2	1.4	1.5	-1.0
Time in closed arm after self-admin	0.3	0.4	0.9	0.8	-0.7	-0.5	0.9	-0.6	-0.6	0.2	0.1	-0.5
Time in open arm before self-admin	1.0	1.2	4.2	0.5	-0.4	0.5	1.0	1.2	1.1	-1.6	-2.0	0.5
Time in open arm after self-admin	0.5	0.5	1.0	-0.5	0.3	0.7	-0.4	1.0	1.0	-0.8	-0.9	0.7
Bone: periosteal estimation	0.7	1.7	4.5	0.5	0.1	-1.4	0.3	-2.0	-2.1	1.1	1.3	-0.9
Bone: periosteal perimeter	0.4	0.7	2.0	-0.0	0.4	-0.8	-0.2	-1.4	-1.4	0.7	0.9	-0.6
Bone: post-yield work	2.6	4.4	9.3	-0.4	0.6	-1.9	0.3	-3.0	-3.0	2.1	2.1	-2.8
Progressive ratio test 1 active lever presses	0.5	0.9	1.8	0.7	-0.6	-0.9	0.4	-1.1	-1.1	1.2	1.3	-0.7
Progressive ratio test 1 breakpoint	0.5	0.8	1.8	0.6	-0.5	-0.9	0.3	-1.1	-1.1	1.2	1.4	-0.6
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.5	0.1	-0.3	0.1	0.0	-0.1	-0.1	0.6	0.7	-0.3
Progressive ratio test 2 active lever presses	3.2	4.5	7.7	1.9	-1.8	-2.1	1.3	-2.3	-2.3	2.6	2.8	-1.7
Progressive ratio test 2 breakpoint	3.4	4.4	7.6	1.8	-1.8	-2.1	1.2	-2.2	-2.2	2.5	2.8	-1.6
Progressive ratio test 2 inactive lever presses	3.5	11.0	15.4	3.3	-3.4	-3.4	2.7	-3.0	-3.0	3.9	3.9	-3.0
Incentive Sensitization - Responses	0.3	0.8	1.7	0.3	-0.2	-0.9	0.2	-1.3	-1.3	1.0	1.1	-0.9
Incentive Sensitization - Breakpoint	0.5	1.1	2.0	0.5	-0.5	-1.1	0.4	-1.4	-1.4	1.2	1.3	-1.0
Sum of active levers in priming session hrs 5-6	1.6	1.5	5.0	-1.3	1.1	1.1	-2.2	0.8	0.9	0.1	0.9	1.5
Progressive ratio	0.2	0.7	1.5	-1.0	1.2	-0.1	-0.4	-1.1	-1.1	0.3	0.2	-1.0
Food seeking constrained by brief footshock	0.1	0.1	0.4	-0.1	0.1	0.3	0.0	0.1	0.1	-0.6	-0.6	0.4
Seeking ratio, punishment vs. effort	0.4	0.9	2.3	1.3	-1.5	-0.2	1.1	0.8	0.8	-0.6	-0.7	0.7
Retroperitoneal fat weight	7.1	31.9	50.5	7.1	-6.8	-6.5	6.5	-4.8	-4.8	4.8	4.2	-4.4
Reaction time number correct	0.2	0.6	1.9	-0.5	0.5	0.7	-0.8	0.6	0.4	-0.8	-0.5	1.4
Reaction time mean minus median	0.4	2.4	6.1	-2.5	2.3	1.7	-2.4	0.6	0.7	-0.5	-0.2	0.6
Reaction time mean minus median AUC	0.2	1.6	3.5	-1.8	1.6	1.5	-1.9	0.7	0.8	-0.6	-0.2	0.9
Reaction time num false alarms	0.3	0.6	1.3	0.9	-0.9	-0.2	1.1	0.4	0.3	-0.8	-1.1	0.3
Reaction time num false alarms AUC	0.3	0.7	2.2	0.2	-0.2	0.5	0.5	0.8	0.7	-1.2	-1.5	0.7
Reaction time trials correct on left	0.2	0.6	1.9	-0.5	0.5	0.7	-0.8	0.6	0.4	-0.8	-0.5	1.4
Reaction time trials on left	0.2	0.7	2.2	-0.6	0.6	0.8	-1.0	0.7	0.5	-0.9	-0.6	1.5
Reaction time mean	0.1	0.2	0.6	-0.6	0.1	0.3	-0.5	0.2	0.3	0.6	0.7	-0.4
Reaction time mean AUC	0.1	0.3	0.8	-0.5	0.1	0.2	-0.4	-0.0	0.2	0.8	0.9	-0.7
Median of all reaction times	0.2	0.3	1.0	0.0	-0.5	-0.3	0.2	-0.1	-0.0	1.0	1.0	-0.8
Reaction time omissions	1.0	1.6	3.2	-1.8	1.5	1.7	-1.6	1.0	1.0	-0.7	-0.5	0.9
Reaction time false alarm rate	0.3	0.4	1.2	0.8	-0.7	-0.3	1.1	0.1	0.1	-0.5	-0.9	-0.2
Reaction time premature initiation rate	3.1	4.8	8.2	-1.8	1.9	2.2	-1.5	2.0	2.1	-2.8	-2.9	2.1
Reaction time premature initiations	2.5	7.7	10.8	-2.4	2.4	2.9	-2.3	2.7	2.6	-3.3	-3.1	3.0
Std. dev. reaction times	0.3	0.9	2.3	-1.5	1.2	1.1	-1.4	0.5	0.6	-0.0	0.2	0.3
Reaction time trials completed	0.2	0.7	2.2	-0.6	0.6	0.8	-1.0	0.7	0.5	-0.9	-0.6	1.5
Reaction time trials AUC	0.1	0.5	1.8	-0.4	0.4	0.6	-0.7	0.5	0.3	-0.8	-0.6	1.3
Run reversals in cocaine runway, females	0.4	0.4	1.4	-0.1	0.6	0.0	0.6	-0.5	-0.5	-0.8	-1.2	-0.5
Run reversals in cocaine runway, males	0.2	0.2	0.9	0.7	-0.6	-0.1	0.1	0.2	0.2	-0.2	-0.0	0.9
Latency to leave start box in cocaine runway	0.6	0.8	1.9	0.4	-0.1	-0.8	0.7	-1.2	-1.2	0.8	0.6	-1.4
Latency to leave start box in cocaine runway, F	0.2	0.2	1.0	0.0	0.1	-0.2	0.4	-0.3	-0.3	0.5	0.3	-1.0
Latency to leave start box in cocaine runway, M	0.6	0.5	1.8	0.4	-0.1	-0.8	0.3	-1.3	-1.3	0.3	0.4	-0.5
Std. dev. time between licks in bursts	0.3	0.6	1.9	0.4	-0.2	0.2	0.4	0.5	0.5	-1.3	-1.4	0.9
Total sessions with >9 infusions	0.8	0.9	2.3	0.4	-0.2	-1.1	0.5	-1.5	-1.5	0.8	0.8	-1.0
Short access day 1 total inactive lever presses	1.5	3.0	4.5	2.1	-2.0	-1.6	2.0	-1.7	-1.7	1.5	1.3	-1.5
Short access day 10 total inactive lever presses	0.0	0.3	1.1	0.8	-0.8	0.2	1.0	0.0	0.0	0.1	-0.2	-0.4
Short access day 1 total infusions	2.0	3.9	5.8	1.9	-1.6	-2.1	1.9	-2.4	-2.4	1.7	1.6	-2.0
Short access day 10 total infusions	2.7	4.4	9.1	1.2	-0.8	-2.1	1.4	-3.0	-3.0	1.9	1.9	-2.4
Short access total infusions	2.2	3.1	6.8	1.3	-0.9	-1.8	1.4	-2.6	-2.6	1.4	1.3	-1.7
Short access day 1 locomotion	1.7	2.8	3.4	1.6	-1.5	-1.8	1.6	-1.9	-1.9	1.6	1.4	-1.8
Short access day 10 total locomotion	0.8	3.1	4.6	1.3	-1.2	-1.7	1.2	-2.1	-2.1	2.0	1.9	-1.9
Short access total locomotion	2.4	3.6	5.0	1.6	-1.4	-2.0	1.5	-2.2	-2.2	2.0	2.0	-2.0
One hour access (0.3 mA shock)	6.5	7.7	10.0	3.2	-3.0	-3.0	2.6	-2.7	-2.7	2.8	2.8	-2.2
Compulsive drug intake	4.1	6.0	10.3	-1.6	1.6	2.3	-1.2	2.9	2.9	-3.0	-3.2	2.4
One hour access (shock baseline)	4.5	11.9	16.7	3.3	-3.3	-3.5	2.6	-3.5	-3.5	4.0	4.1	-3.0
Social response proportion	0.4	0.5	1.1	-1.0	1.1	0.8	-1.0	0.5	0.4	-0.3	-0.1	0.4
Social responses	0.4	0.5	0.7	-0.6	0.6	0.9	-0.7	0.8	0.7	-0.7	-0.6	0.8
Social time	0.5	0.8	1.7	-0.7	0.6	1.1	-0.8	1.0	0.9	-1.0	-0.8	1.3
Soleus weight	2.9	8.5	14.6	3.8	-3.7	-3.3	3.5	-2.2	-2.1	2.5	2.3	-2.2
Bone: stiffness	0.7	1.3	4.2	-1.9	2.1	0.7	-1.8	-0.4	-0.3	-0.2	0.1	0.1
Tibialis anterior weight	7.2	25.0	39.9	-6.0	6.3	5.5	-6.2	3.4	3.3	-4.5	-3.7	4.8
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.4	-0.4	0.5	-0.2	-0.2	-0.6	-0.6	0.1	0.2	-0.3
Time to tail flick, vehicle, after self-admin	0.2	0.5	1.1	-0.5	0.8	-0.2	0.1	-1.0	-1.0	-0.5	-0.8	-0.6
Time to tail flick, test, before self-admin	2.6	3.0	4.9	1.8	-1.5	-2.0	2.2	-1.8	-2.0	1.2	0.8	-2.0
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.3	0.2	0.1	-0.6	-0.1	-0.2	0.2	0.4	0.2
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.7	-0.4	0.6	0.2	-0.1	-0.2	-0.2	-0.7	-0.9	0.0
Delta time to tail flick, test, before/after SA	3.1	3.8	6.7	-1.9	1.5	2.1	-2.6	2.3	2.3	-1.1	-0.5	2.4
Tibia length	0.6	1.7	6.0	-1.8	1.8	0.8	-2.5	0.2	0.2	0.2	0.9	1.0
Ambulatory time before self-admin	0.2	0.5	0.8	-0.8	0.7	-0.1	-0.8	-0.5	-0.6	0.8	0.9	-0.6
Ambulatory time after self-admin	0.3	0.4	1.1	0.2	-0.4	-0.5	0.3	-0.3	-0.4	1.0	0.9	-1.0
Bone: tissue strength	0.1	0.1	0.2	-0.0	-0.1	-0.2	0.0	-0.2	-0.2	0.4	0.4	-0.2
Total heroin consumption	4.1	4.9	8.4	-2.9	2.7	2.6	-2.6	1.9	1.8	-1.7	-1.5	1.5
Bone: trabecular number	0.3	0.5	1.2	-1.0	1.1	-0.2	-0.7	-0.8	-0.9	0.4	0.4	-0.7
Bone: trabecular spacing	0.2	0.3	0.8	0.7	-0.9	0.1	0.8	0.4	0.5	-0.4	-0.6	0.2
Bone: trabecular thickness	0.7	1.0	1.5	0.8	-0.7	-1.1	0.9	-1.1	-1.1	1.0	0.9	-1.2
Bone: trabecular tissue density	2.0	3.5	6.4	2.4	-2.5	-2.0	2.0	-1.1	-1.1	1.9	1.8	-1.3
Water consumed over 24 hours	1.2	2.3	3.2	-1.6	1.3	1.7	-1.4	1.8	1.8	-1.3	-1.3	1.2
Number of responses in last shaping day	0.2	0.2	0.4	0.0	-0.1	0.5	0.0	0.6	0.6	-0.5	-0.5	0.5