Smim27

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Smim27 0.05 0.03 1.8e-07 0.06 0.06 0.06 0.06 3.5e-07 2.5e-07 7.3e-07 6.0e-07
2 BLA gene expression Smim27 0.08 0.05 4.2e-04 0.05 0.05 0.05 0.04 9.1e-04 8.8e-04 9.8e-04 3.2e-03
3 Liver gene expression Smim27 0.08 0.06 6.4e-04 0.02 0.01 0 0.02 3.5e-03 7.5e-03 7.6e-02 5.3e-03
4 LHb mRNA stability Smim27 0.13 0.08 5.2e-03 0.04 0.07 0.01 0.03 5.0e-02 9.3e-03 2.1e-01 6.7e-02
5 NAcc gene expression Smim27 0.04 0.02 8.3e-05 0.04 0.02 0.02 0.04 3.5e-06 1.3e-04 1.5e-04 3.2e-06
6 Liver mRNA stability Smim27 0.03 0.02 5.1e-03 0.02 0.01 0 0.02 1.7e-03 1.1e-02 1.1e-01 3.0e-03
7 IL gene expression Smim27 0.14 0.1 2.3e-03 0.15 0.03 0.11 0.11 2.1e-04 5.7e-02 1.4e-03 1.3e-03
8 IC gene expression Smim27 0.14 0.08 5.3e-04 0.04 0.03 0.05 -0 8.3e-03 2.0e-02 2.9e-03 4.8e-01
9 Adipose gene expression Smim27 0.27 0.14 3.6e-13 0.09 0.11 0.1 0.11 5.2e-10 3.8e-12 5.0e-11 5.9e-12
10 Adipose mRNA stability Smim27 0.03 0.02 3.8e-03 0.01 0.01 0.01 0.01 1.6e-02 5.5e-02 3.3e-02 3.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.81.53.2-1.4-1.11.1-1.6-1.10.81.81.40.0-0.9
Area under the delay curve0.30.51.10.70.4-1.00.90.7-0.4-0.9-0.8-0.20.5
BMI with tail0.93.37.4-2.1-1.92.7-2.0-1.62.11.81.7-0.5-0.2
BMI without tail0.63.35.8-2.4-2.22.2-2.3-1.81.91.81.2-0.90.1
Body weight2.511.117.9-3.8-3.94.2-3.4-3.44.02.62.8-2.61.6
Weight adjusted by age0.31.02.3-0.6-0.81.5-0.5-0.90.90.21.2-1.41.1
Bone surface0.71.53.4-1.4-1.41.8-1.3-1.01.41.21.0-0.50.1
Bone volume0.51.01.8-1.2-1.11.3-1.2-0.80.71.30.8-0.1-0.4
Breakpoint value in progressive ratio session0.81.55.10.7-0.10.31.30.7-0.3-2.1-0.7-1.32.3
Number of licking bursts2.16.310.1-2.9-2.52.1-3.1-3.02.43.22.8-1.0-0.6
Context. condit. distance diff. score0.20.30.90.60.7-0.90.40.4-0.6-0.1-0.00.5-0.4
Locomotion velocity, session 12.02.311.1-0.6-1.4-0.10.0-0.80.3-0.7-0.1-2.83.3
Locomotion distance, session 10.70.93.7-0.5-1.0-0.1-0.1-0.6-0.1-0.20.0-1.81.9
Locomotion velocity, session 21.21.52.5-1.5-1.30.9-1.6-1.51.01.51.2-0.3-0.4
Locomotion distance, session 21.42.03.3-1.6-1.70.7-1.4-1.71.11.21.3-1.81.2
Locomotion velocity, session 30.40.52.40.0-0.3-0.50.1-0.5-0.3-0.60.8-1.01.5
Locomotion distance, session 31.11.32.3-1.1-1.31.1-1.0-1.30.80.41.5-1.31.2
Stereotopy head waving bouts, day 30.30.30.8-0.6-0.8-0.1-0.3-0.70.2-0.1-0.3-0.70.9
Stereotopy head waving duration, day 30.10.10.4-0.5-0.60.0-0.4-0.60.30.3-0.2-0.10.1
Locomotion velocity, session 70.10.20.50.40.4-0.30.40.2-0.7-0.40.00.4-0.1
Locomotion distance, session 70.10.20.8-0.0-0.1-0.1-0.1-0.5-0.40.10.9-0.50.5
Stereotopy head waving bouts, day 71.92.23.5-1.9-1.81.3-1.8-1.61.41.61.3-1.00.4
Stereotopy head waving duration, day 71.62.03.3-1.8-1.81.6-1.7-1.31.51.51.0-0.70.1
Locomotion velocity, session 80.60.83.1-0.5-0.8-0.9-0.2-0.70.00.10.1-1.61.7
Locomotion distance, session 80.40.51.8-0.3-0.5-0.6-0.2-0.6-0.10.20.6-1.41.3
Degree of sensitization distance0.60.61.50.90.9-1.20.80.6-0.7-0.3-0.80.7-0.5
Degree of sensitization stereotypy1.71.92.9-1.7-1.51.4-1.7-1.31.31.71.4-0.70.0
Conditioned locomotion0.30.42.00.0-0.3-0.60.3-0.1-0.4-0.6-0.2-0.81.4
Cocaine response after cond. corrected0.60.92.30.70.1-0.71.10.6-1.0-1.2-1.0-0.81.5
Cocaine response after cond. not corrected0.60.83.10.4-0.3-0.50.80.4-0.8-1.0-0.9-1.11.8
Cocaine response before conditioning0.91.11.7-1.3-1.21.2-1.3-1.11.11.20.9-0.4-0.1
Saline control response1.92.75.3-2.0-2.31.5-1.6-1.71.51.30.7-1.91.4
Bone: connectivity density0.40.71.5-0.8-0.61.0-0.9-0.40.81.20.90.4-0.9
Bone: cortical apparent density0.20.41.70.00.4-0.6-0.20.1-0.00.4-0.51.0-1.3
Bone: cortical area3.04.910.9-2.5-2.13.3-2.5-1.92.72.51.7-0.1-1.2
Bone: cortical porosity0.40.41.90.40.5-1.20.20.2-1.40.2-0.20.3-0.5
Bone: cortical porosity0.10.10.5-0.2-0.2-0.6-0.2-0.3-0.70.50.2-0.30.0
Bone: cortical thickness1.42.34.4-1.5-0.92.0-1.8-1.11.42.11.20.7-1.9
Bone: cortical thickness0.20.31.40.10.40.5-0.10.30.20.50.30.6-1.2
Bone: cortical tissue density0.20.31.40.10.4-0.7-0.10.1-0.20.2-0.60.9-1.2
Condit. Reinf. active minus inactive responses0.30.30.8-0.6-0.50.5-0.7-0.70.50.50.9-0.50.2
Condit. Reinf. active-inactive response ratio0.80.91.51.21.2-1.11.01.1-0.7-0.9-0.80.8-0.4
Condit. Reinf. active responses2.22.94.0-1.9-1.82.0-1.9-1.81.71.61.9-1.10.2
Condit. Reinf. inactive responses3.03.97.3-2.3-2.12.7-2.2-2.11.92.12.1-0.9-0.1
Incentive salience index mean3.14.05.3-2.3-2.32.0-2.2-2.21.91.92.2-1.70.8
Condit. Reinf. lever presses8.713.118.2-4.1-4.33.7-3.9-4.03.53.33.8-3.21.7
Condit. Reinf. active minus inactive responses0.50.82.1-0.9-0.81.4-0.9-0.61.40.80.8-0.3-0.2
Condit. Reinf. active-inactive response ratio0.00.10.2-0.00.10.2-0.20.10.20.30.40.1-0.5
Condit. Reinf. active responses1.52.24.4-1.7-1.62.1-1.6-1.42.11.31.1-0.5-0.0
Condit. Reinf. inactive responses1.92.85.3-2.0-1.72.3-1.9-1.72.21.71.1-0.0-0.6
Condit. Reinf. lever presses1.92.76.3-1.8-1.52.5-1.8-1.62.11.61.20.4-1.0
Condit. Reinf. lever reinforcers received1.82.65.4-1.8-1.72.2-1.7-1.52.31.41.2-0.50.0
Conditioned reinforcement - actives0.00.10.5-0.3-0.30.3-0.4-0.70.50.10.10.5-0.3
Conditioned reinforcement - inactives0.00.11.0-0.1-0.10.2-0.1-0.11.00.00.1-0.00.2
Conditioned locomotion0.00.10.60.10.1-0.7-0.10.0-0.10.00.4-0.10.1
Patch foraging indifference point 0 sec0.61.78.2-0.6-1.4-0.1-0.0-1.20.3-0.3-0.1-2.22.9
Patch foraging indifference point AUC2.76.312.6-2.8-2.73.6-2.7-2.73.21.82.2-1.40.6
Delay disc. indifference point, 0s delay0.30.40.60.70.4-0.80.80.5-0.7-0.6-0.3-0.50.5
Delay disc. indifference point, 16s delay0.60.81.60.80.3-0.61.30.8-0.2-1.3-1.2-0.31.3
Delay disc. indifference point, 2s delay0.20.20.5-0.3-0.1-0.7-0.4-0.3-0.30.7-0.20.4-0.7
Delay disc. indifference point, 24s delay0.20.30.80.50.4-0.90.70.6-0.4-0.4-0.90.3-0.0
Delay disc. indifference point, 4s delay0.20.20.60.40.5-0.80.40.6-0.1-0.4-0.10.1-0.1
Delay disc. indifference point, 8s delay0.00.00.20.0-0.0-0.40.10.10.1-0.2-0.1-0.1-0.0
Indifference point function ln k0.61.84.01.61.3-2.01.61.6-1.5-1.1-1.10.50.2
Indifference point function log k0.61.84.01.61.3-2.01.61.6-1.5-1.1-1.10.50.2
Patch foraging total patch changes 0 sec0.72.07.1-1.1-1.70.2-0.6-1.60.60.30.4-2.32.7
Patch foraging total patch changes 12 sec1.01.43.1-1.2-1.21.8-1.2-1.51.50.71.0-0.50.5
Patch foraging total patch changes 18 sec0.10.30.5-0.5-0.70.5-0.2-0.60.7-0.1-0.4-0.50.7
Patch foraging total patch changes 24 sec0.62.03.3-1.6-1.81.4-1.4-1.71.21.10.9-1.61.1
Patch foraging total patch changes 6 sec1.72.94.9-1.8-2.21.6-1.3-2.11.90.40.6-1.92.0
Patch foraging time to switch 0 sec0.93.55.42.12.3-2.01.82.0-1.6-1.5-1.62.1-1.4
Patch foraging water rate 0 sec0.62.14.1-1.5-1.71.2-1.3-1.71.20.81.2-2.01.6
Patch foraging water rate 12 sec0.10.21.0-0.3-0.50.2-0.3-0.5-0.20.40.3-1.00.5
Patch foraging water rate 18 sec0.30.72.1-0.8-0.40.9-1.1-0.50.11.51.10.1-1.1
Patch foraging water rate 24 sec0.20.41.4-0.10.2-0.4-0.50.1-0.51.00.60.2-1.2
Patch foraging water rate 6 sec1.21.73.6-1.6-1.50.3-1.7-1.30.71.91.5-1.30.1
Seeking ratio, delayed vs. immediate footshock1.31.94.7-1.3-1.30.8-1.5-2.21.61.21.7-0.80.2
Distance traveled before self-admin2.55.510.8-2.6-2.61.3-2.7-2.81.52.13.3-2.51.1
Distance traveled after self-admin2.54.310.3-2.3-1.70.9-2.7-2.21.73.22.8-1.0-0.8
Extensor digitorum longus weight4.517.925.9-5.0-4.74.9-4.8-4.75.14.43.5-2.40.3
Bone: elastic displacement5.97.510.53.23.2-2.92.93.0-3.0-2.6-2.62.2-1.1
Bone: elastic work3.44.59.92.02.5-1.31.62.0-2.3-0.8-1.73.1-2.8
Bone: endosteal estimation1.02.45.2-1.7-1.92.0-1.3-1.42.30.80.8-1.41.3
Bone: endosteal perimeter1.12.74.8-1.8-2.12.2-1.4-1.62.20.80.6-1.31.4
Epididymis fat weight0.10.51.1-0.8-0.70.7-0.8-0.40.71.10.6-0.4-0.1
Delta time in closed arm before/after self-admin0.30.30.8-0.00.3-0.8-0.10.2-0.30.3-0.50.9-0.7
Delta time in open arm before/after self-admin0.10.20.50.0-0.20.50.3-0.10.5-0.7-0.40.00.5
Diff in mean of infusions in LGA sessions0.30.52.50.40.70.20.30.50.5-0.5-0.41.6-1.0
Delay discount exponential model param0.40.51.0-0.7-0.51.0-0.9-0.70.40.90.70.1-0.5
Extinction: sum of active levers before priming1.01.52.71.71.5-1.31.61.4-1.1-1.2-0.60.60.1
Active lever presses in extinction session 60.10.10.30.10.00.50.20.6-0.4-0.2-0.1-0.3-0.0
Bone: final force1.62.64.3-2.1-1.92.0-2.0-1.81.41.91.1-0.5-0.3
Bone: final moment1.32.13.8-1.8-1.61.9-1.8-1.51.21.80.9-0.1-0.7
Food consumed during 24 hour testing period1.22.55.4-1.6-1.82.0-1.4-1.52.30.91.1-1.41.1
Glucose1.62.65.5-1.7-1.82.4-1.5-1.62.21.21.2-1.10.6
Heart weight1.01.66.7-1.2-1.22.6-1.0-0.71.80.80.7-0.60.2
Delay discount hyperbolic model param0.30.40.9-0.6-0.41.0-0.8-0.60.40.90.60.2-0.5
Intermittent access intake day 1-15 change0.10.62.3-0.8-0.61.1-0.8-0.61.50.30.20.4-0.2
Intermittent access intake escalation0.10.61.9-0.8-0.61.0-0.8-0.51.40.30.20.6-0.5
Intermittent access intake escalation 20.61.11.8-1.1-0.50.5-1.3-0.91.31.30.90.9-1.3
Intermitt. access day 1 inactive lever presses0.10.72.5-0.6-0.60.4-0.7-1.00.50.41.6-1.10.8
Intermitt. access day 15 inactive lever presses0.00.20.3-0.5-0.40.5-0.5-0.40.50.50.5-0.50.2
Intermitt. access escalation Index0.00.10.4-0.5-0.40.2-0.4-0.6-0.00.30.1-0.10.1
Intermittent access day 1 total infusions0.82.34.71.41.2-1.61.71.2-1.7-2.1-2.20.60.3
Intermittent access day 15 total infusions0.10.31.4-0.00.2-0.10.0-0.10.4-0.6-0.91.2-0.6
Intermittent access terminal intake (last 3 days)0.10.20.7-0.5-0.3-0.5-0.5-0.90.40.2-0.20.6-0.3
Intermittent access total infusions0.10.10.5-0.2-0.2-0.0-0.0-0.40.1-0.6-0.70.50.1
Intermittent access day 1 locomotion1.01.82.91.41.1-1.71.51.3-1.5-1.6-1.70.30.2
Intermittent access day 15 total locomotion0.51.94.91.41.2-1.01.61.6-0.8-2.2-1.80.70.2
Intermittent access total locomotion1.51.83.21.31.3-1.51.31.5-1.2-1.4-1.81.3-0.7
Intermittent access standard deviation0.00.20.7-0.2-0.20.0-0.3-0.40.8-0.20.5-0.10.4
Left kidney weight0.65.011.3-2.3-2.83.4-1.6-2.01.70.91.2-2.72.4
Right kidney weight0.43.012.5-1.8-2.13.5-1.2-1.11.80.80.3-1.21.2
Cocaine induced anxiety0.20.61.2-0.7-0.8-1.0-0.8-0.6-0.41.10.6-1.10.3
Post-drug Anxiety2.12.43.8-1.8-1.90.7-1.6-1.70.81.81.7-2.00.8
Baseline Anxiety0.91.54.8-1.0-0.82.2-1.0-0.91.90.91.4-0.3-0.3
Tail length0.94.97.7-2.8-2.71.9-2.6-2.62.62.01.6-1.60.8
Length with tail1.46.310.1-2.8-3.22.5-2.2-2.72.71.51.7-2.92.4
Length without tail0.21.33.7-0.6-1.11.4-0.2-0.71.1-0.10.6-1.91.9
Times rat made contact with spout0.30.40.9-0.6-0.40.1-0.8-0.70.20.90.80.3-0.6
Lifetime Intake0.20.20.6-0.3-0.40.1-0.1-0.70.3-0.8-0.60.10.5
Liver weight, left0.30.41.2-0.6-0.80.7-0.4-0.41.0-0.1-0.0-1.10.6
Liver weight, right0.40.71.40.80.8-0.10.91.0-0.2-1.2-1.20.9-0.3
Locomotor activity0.10.20.60.30.40.80.3-0.0-0.5-0.3-0.30.5-0.2
Locomotor testing distance0.10.20.90.30.10.60.5-0.0-0.2-0.6-0.4-0.60.9
Locomotor testing rearing0.20.91.9-0.9-0.91.4-0.9-1.01.20.60.9-0.70.7
Locomotion in novel chamber0.20.21.3-0.2-0.1-0.7-0.30.1-0.51.10.2-0.2-0.4
Locomotion in novel chamber post-restriction0.61.94.5-1.7-1.21.4-1.8-1.01.52.10.7-0.1-1.1
Fecal boli incidents, locomotor time 11.02.64.71.81.7-1.51.91.7-1.2-1.8-2.21.5-0.2
Change in fecal boli incidents, locomotor task0.70.71.9-0.9-1.00.5-0.9-1.00.00.60.8-1.40.8
Time >=10cm from walls, locomotor time 10.20.20.6-0.0-0.3-0.20.2-0.1-0.8-0.1-0.7-0.40.7
Bouts of movement, locomotor time 10.50.61.61.21.3-0.21.00.9-0.6-0.40.10.8-0.4
Total resting periods, locomotor time 11.31.53.01.61.7-0.61.41.4-1.2-0.7-0.61.6-0.8
Rest time, locomotor task time 11.62.66.91.21.7-0.80.91.6-2.0-0.6-1.52.6-2.2
Distance moved, locomotor task time 10.92.75.3-1.2-1.51.4-1.1-1.81.60.72.2-2.31.8
Vertical activity count, locomotor time 10.42.46.3-1.2-1.60.8-1.0-1.91.10.61.7-2.52.1
Time >=10cm from walls, locomotor time 20.10.20.90.1-0.2-0.90.1-0.1-0.4-0.1-0.1-0.50.7
Bouts of movement, locomotor time 20.41.46.1-1.3-1.21.1-1.1-0.92.51.00.7-0.60.1
Total resting periods, locomotor time 20.20.84.1-0.9-0.80.8-0.8-0.42.00.70.3-0.2-0.1
Rest time, locomotor task time 20.61.12.10.91.2-0.80.81.1-1.5-0.7-0.81.3-1.0
Distance moved, locomotor task time 20.20.20.8-0.2-0.10.6-0.4-0.60.30.40.90.1-0.2
Vertical activity count, locomotor time 20.20.51.2-0.6-0.90.3-0.5-1.10.40.40.6-1.00.9
Light reinforcement 11.04.610.6-1.8-2.43.3-1.2-2.02.6-0.21.5-2.32.6
Light reinforcement 21.22.66.9-1.2-1.92.2-0.6-1.31.3-0.40.8-2.32.6
Bone: marrow area1.02.45.3-1.7-1.82.0-1.4-1.42.30.90.9-1.21.0
Bone: maximum diameter2.55.110.0-2.7-2.53.2-2.6-2.22.72.31.4-0.7-0.4
Bone: maximum force3.06.09.6-3.0-2.83.1-2.9-2.72.32.72.0-0.9-0.4
Bone: maximum moment2.64.99.0-2.7-2.43.0-2.6-2.32.12.51.8-0.5-0.7
Mean time between licks in bursts0.10.41.20.50.3-0.10.70.90.1-0.8-1.10.10.4
Mean num. licks in bursts1.33.65.12.32.1-1.72.22.2-1.9-2.2-2.01.3-0.1
Cd content in liver1.71.94.0-1.6-1.41.8-1.5-1.32.01.41.2-0.6-0.1
Co content in liver0.30.41.00.50.20.00.80.40.1-0.9-1.0-0.40.8
Cu content in liver1.01.21.71.21.1-1.21.21.2-1.3-1.0-1.30.9-0.5
Fe content in liver0.81.02.80.60.1-1.11.10.8-0.2-1.3-1.7-0.61.3
K content in liver0.30.30.50.50.2-0.70.60.3-0.3-0.7-0.7-0.20.6
Mg content in liver0.91.01.51.10.9-1.01.21.1-1.1-1.2-1.10.30.2
Mn content in liver1.92.13.8-1.6-1.21.2-1.8-1.51.81.91.6-0.1-0.8
Na content in liver0.91.01.61.11.1-1.21.11.3-1.0-0.8-1.20.8-0.4
Rb content in liver4.04.68.42.52.2-1.72.72.5-2.0-2.9-2.21.00.4
Se content in liver2.93.56.9-1.9-1.52.0-2.2-1.82.02.22.6-0.4-0.8
Sr content in liver0.40.30.7-0.6-0.50.3-0.8-0.70.40.80.8-0.1-0.3
Zn content in liver0.10.10.4-0.1-0.00.4-0.1-0.0-0.10.3-0.10.5-0.6
Bone: minimum diameter0.10.31.00.10.21.00.10.60.4-0.1-0.50.7-0.6
Time in familiar zone, hab. session 11.41.57.70.61.20.00.00.7-0.40.60.12.0-2.8
Time in novel zone, hab. session 12.12.36.60.90.1-1.21.60.9-1.1-2.1-2.0-1.12.6
Total zone transitions, hab. session 10.20.31.30.50.6-1.00.30.0-1.1-0.10.4-0.0-0.2
Total locomotion distance, hab. session 10.60.82.9-0.40.20.1-0.9-0.6-0.41.31.30.7-1.7
Locomotion velocity, hab. session 11.11.63.8-1.2-0.60.7-1.6-1.40.51.91.90.2-1.4
Time in familiar zone, hab. session 21.11.23.51.01.30.30.71.2-0.6-0.5-0.51.9-1.8
Time in novel zone, hab. session 21.31.43.50.70.1-1.71.00.5-1.0-1.1-1.4-1.11.9
Total zone transitions, hab. session 20.81.02.9-0.8-1.10.3-0.7-1.00.40.51.3-1.71.4
Total locomotion distance, hab. session 20.81.11.9-1.2-1.10.8-1.2-1.20.71.31.4-0.7-0.0
Locomotion velocity, hab. session 20.91.22.1-1.2-1.10.8-1.3-1.20.71.41.4-0.7-0.2
Novel to familiar place preference ratio3.24.26.42.11.6-2.52.31.9-2.4-2.5-2.50.21.3
Novelty place preference4.25.38.12.42.0-2.82.62.2-2.7-2.7-2.80.51.0
Time in novel zone, NPP test5.06.18.72.62.1-3.02.82.4-2.9-2.9-2.90.61.2
Total zone transitions, NPP test0.71.02.9-0.9-1.10.5-0.8-0.90.20.61.1-1.71.2
Total locomotion distance, NPP test1.62.23.4-1.6-1.61.3-1.6-1.81.01.31.8-1.70.9
Locomotion velocity, NPP test1.82.54.0-1.8-1.71.3-1.8-1.91.11.52.0-1.60.7
Intraocular pressure1.32.13.3-1.7-1.71.8-1.5-1.41.51.11.3-1.30.6
Delta distance traveled before/after self-admin0.30.31.4-0.3-0.10.1-0.4-0.30.71.2-0.10.4-0.6
Delta ambulatory time before/after self-admin0.10.20.9-0.10.2-0.1-0.2-0.10.31.0-0.10.3-0.7
Parametrial fat weight0.20.41.30.3-0.00.20.50.20.4-1.0-0.4-0.81.1
Pavlov. Cond. lever latency6.68.411.63.43.4-2.73.23.3-3.0-2.7-3.02.4-1.1
Pavlov. Cond. magazine entry latency0.30.41.1-0.9-1.00.4-0.6-0.50.60.5-0.3-0.70.5
Pavlov. Cond. change in total contacts2.12.23.1-1.7-1.81.0-1.6-1.71.71.11.5-1.61.2
Pavlov. Cond. index score2.63.35.3-2.3-2.31.6-2.1-2.01.91.91.5-1.50.5
Pavlov. Cond. latency score2.43.15.0-2.2-2.21.5-2.0-2.01.81.71.4-1.40.6
Pavlov. Cond. lever contacts5.97.210.0-3.2-3.22.3-3.0-3.12.72.62.7-2.21.0
Pavlov. Cond. magazine entry number0.30.40.90.91.0-0.40.70.5-0.4-0.70.00.5-0.1
Pavlov. Cond. intertrial magazine entries0.10.10.3-0.4-0.20.4-0.5-0.50.40.30.5-0.2-0.1
Pavlov. Cond. lever-magazine prob. diff.2.42.94.7-2.2-2.11.5-2.0-1.91.81.91.4-1.10.2
Pavlov. Cond. response bias3.24.06.4-2.4-2.51.9-2.2-2.22.02.01.8-1.70.9
Pavlov. Cond. lever latency1.42.03.41.61.3-1.81.71.5-1.7-1.5-1.0-0.51.1
Pavlov. Cond. magazine entry latency0.30.41.10.40.5-0.30.50.5-0.3-0.4-1.00.9-0.8
Pavlov. Cond. change in total contacts0.40.93.7-0.5-0.01.0-0.7-0.40.60.80.41.6-1.9
Pavlov. Cond. index score0.30.41.8-0.20.00.6-0.3-0.20.40.3-0.31.2-1.3
Pavlov. Cond. latency score0.30.52.2-0.4-0.00.7-0.5-0.30.60.5-0.01.3-1.5
Pavlov. Cond. lever contacts1.01.52.7-1.4-1.11.6-1.4-1.21.41.30.70.6-1.1
Pavlov. Cond. magazine entry number0.40.52.60.0-0.4-0.10.20.00.1-0.40.2-1.31.6
Pavlov. Cond. intertrial magazine entries0.20.40.7-0.6-0.60.5-0.7-0.50.80.60.9-0.80.5
Pavlov. Cond. lever-magazine prob. diff.0.30.52.2-0.20.10.5-0.3-0.10.40.4-0.31.4-1.5
Pavlov. Cond. response bias0.50.71.8-0.8-0.51.0-0.9-0.70.60.80.21.0-1.4
Time in closed arm before self-admin0.20.30.70.80.70.40.80.5-0.4-0.8-0.50.4-0.2
Time in closed arm after self-admin0.30.40.70.60.8-0.50.50.6-0.5-0.4-0.30.8-0.7
Time in open arm before self-admin0.81.02.5-0.8-0.9-1.2-0.8-1.1-0.40.80.6-1.61.1
Time in open arm after self-admin0.91.01.8-1.2-1.40.5-0.9-1.21.20.60.5-1.00.9
Bone: periosteal estimation1.84.39.5-2.4-2.33.1-2.2-1.92.91.91.4-0.90.1
Bone: periosteal perimeter1.02.05.2-1.6-1.82.3-1.1-1.12.10.60.2-0.90.9
Bone: post-yield work2.44.27.2-2.4-2.62.7-2.0-2.22.41.41.4-1.71.1
Progressive ratio test 1 active lever presses0.20.30.80.2-0.0-0.70.4-0.2-0.5-0.8-0.90.10.6
Progressive ratio test 1 breakpoint0.10.20.60.1-0.2-0.70.3-0.3-0.4-0.7-0.80.00.6
Progressive ratio test 1 inactive lever presses0.30.92.2-0.9-1.20.5-0.7-1.50.9-0.00.4-1.11.3
Progressive ratio test 2 active lever presses0.30.41.60.40.1-0.30.7-0.00.1-1.3-1.20.10.8
Progressive ratio test 2 breakpoint0.40.51.80.40.1-0.40.7-0.00.1-1.3-1.20.10.8
Progressive ratio test 2 inactive lever presses0.00.10.5-0.3-0.30.2-0.3-0.70.7-0.20.0-0.00.4
Incentive Sensitization - Responses0.10.20.70.0-0.1-0.30.3-0.30.6-0.8-0.90.10.6
Incentive Sensitization - Breakpoint0.10.31.10.20.1-0.30.4-0.10.5-1.0-1.10.20.6
Sum of active levers in priming session hrs 5-62.72.57.21.81.2-0.82.21.9-0.7-2.7-1.5-0.11.3
Progressive ratio0.10.31.10.1-0.00.70.30.41.1-0.5-0.3-0.40.5
Food seeking constrained by brief footshock7.99.915.7-3.6-4.02.9-3.3-3.33.82.52.3-3.32.0
Seeking ratio, punishment vs. effort1.33.04.9-2.1-2.21.1-2.1-2.21.21.91.6-1.40.5
Retroperitoneal fat weight0.41.82.81.51.7-1.61.41.6-1.0-1.0-1.61.0-0.7
Reaction time number correct0.10.20.70.2-0.0-0.50.30.2-0.2-0.6-0.6-0.40.8
Reaction time mean minus median0.21.67.2-0.00.70.5-0.50.10.61.0-0.12.5-2.7
Reaction time mean minus median AUC0.21.45.0-0.70.01.0-1.1-0.51.31.30.51.7-2.2
Reaction time num false alarms0.20.41.6-0.30.10.5-0.4-0.40.10.50.11.1-1.3
Reaction time num false alarms AUC0.30.71.3-0.9-0.61.2-0.9-1.10.70.90.50.4-0.6
Reaction time trials correct on left0.10.20.70.2-0.0-0.50.30.2-0.2-0.6-0.6-0.40.8
Reaction time trials on left0.10.30.60.30.1-0.50.50.3-0.3-0.7-0.7-0.30.8
Reaction time mean1.53.38.31.52.0-1.41.31.7-1.1-0.7-2.12.9-2.4
Reaction time mean AUC1.53.79.51.62.1-1.51.31.8-1.2-0.6-2.23.1-2.6
Median of all reaction times2.64.17.22.02.2-2.01.92.2-1.6-1.4-2.72.4-1.7
Reaction time omissions1.62.55.31.61.4-0.21.92.0-1.3-1.9-2.31.6-0.1
Reaction time false alarm rate0.30.41.3-0.30.00.6-0.4-0.50.00.70.31.0-1.1
Reaction time premature initiation rate2.84.47.22.62.7-1.72.32.3-2.0-2.2-1.52.2-1.2
Reaction time premature initiations1.33.85.82.42.4-1.72.22.1-1.8-2.4-1.61.6-0.6
Std. dev. reaction times0.62.08.40.81.5-0.40.40.9-0.40.3-0.82.9-2.7
Reaction time trials completed0.10.30.60.30.1-0.50.50.3-0.3-0.7-0.7-0.30.8
Reaction time trials AUC0.10.20.50.30.1-0.60.50.3-0.3-0.7-0.6-0.30.7
Run reversals in cocaine runway, females0.20.31.00.40.7-0.20.10.50.10.40.20.7-1.0
Run reversals in cocaine runway, males0.20.20.40.40.50.30.30.4-0.6-0.50.40.2-0.2
Latency to leave start box in cocaine runway0.71.02.4-1.1-1.01.0-1.2-1.20.20.91.6-0.8-0.1
Latency to leave start box in cocaine runway, F0.20.31.00.2-0.10.40.4-0.0-0.5-1.0-0.1-0.60.8
Latency to leave start box in cocaine runway, M3.63.57.5-2.1-1.81.0-2.3-2.31.02.22.7-1.4-0.0
Std. dev. time between licks in bursts0.40.71.40.80.7-0.50.90.8-0.9-0.9-1.21.0-0.3
Total sessions with >9 infusions0.20.31.0-0.5-0.60.2-0.2-1.00.5-0.5-0.4-0.10.6
Short access day 1 total inactive lever presses0.61.32.7-0.9-1.2-0.6-0.8-1.61.20.00.7-1.61.5
Short access day 10 total inactive lever presses0.10.93.1-0.8-0.60.7-1.0-0.71.01.11.7-0.80.3
Short access day 1 total infusions0.30.51.6-0.6-0.80.2-0.4-1.20.7-0.40.2-0.91.1
Short access day 10 total infusions0.40.62.10.40.1-0.80.7-0.1-0.6-1.4-1.1-0.10.9
Short access total infusions0.30.41.3-0.0-0.3-0.40.3-0.60.1-1.1-0.9-0.31.0
Short access day 1 locomotion0.81.42.31.41.3-1.31.51.1-0.9-1.5-1.30.30.2
Short access day 10 total locomotion0.41.52.61.41.6-1.01.21.5-0.8-0.6-1.01.5-1.3
Short access total locomotion0.60.91.61.01.0-1.11.10.9-0.8-1.3-1.00.6-0.2
One hour access (0.3 mA shock)0.20.31.40.1-0.1-0.20.3-0.1-0.2-0.9-1.20.40.5
Compulsive drug intake0.20.30.60.20.3-0.70.20.3-0.70.2-0.70.7-0.6
One hour access (shock baseline)0.20.51.6-0.1-0.40.70.2-0.40.4-1.2-0.4-0.61.3
Social response proportion0.81.03.31.31.2-0.31.21.8-1.0-0.7-0.50.3-0.4
Social responses0.70.94.0-0.9-0.92.0-0.9-0.81.10.40.9-0.50.3
Social time0.20.41.10.1-0.30.80.40.30.6-0.8-1.0-0.10.8
Soleus weight0.51.66.7-0.4-1.20.40.4-0.20.9-1.1-1.3-2.02.6
Bone: stiffness4.27.611.7-3.3-3.03.4-3.2-2.92.93.02.6-1.1-0.3
Tibialis anterior weight6.221.231.2-5.6-5.54.5-5.2-5.55.34.43.6-3.31.4
Time to tail flick, vehicle, before self-admin1.01.23.51.21.20.51.31.2-0.7-1.9-0.71.0-0.3
Time to tail flick, vehicle, after self-admin0.20.52.5-0.4-0.31.6-0.30.31.2-0.1-0.20.3-0.6
Time to tail flick, test, before self-admin0.30.30.7-0.7-0.60.4-0.7-0.80.80.40.3-0.2-0.1
Time to tail flick, test, after self-admin0.50.51.7-0.5-0.3-0.2-0.6-0.30.10.9-0.61.1-1.3
Delta time to tail flick, vehicle, before/after SA0.60.71.6-1.1-1.10.7-0.9-0.41.30.9-0.1-0.5-0.0
Delta time to tail flick, test, before/after SA0.50.71.40.60.7-0.80.60.7-0.9-0.1-1.11.2-0.8
Tibia length0.71.84.1-1.2-1.61.4-0.8-0.91.90.20.5-2.01.7
Ambulatory time before self-admin1.44.28.9-2.2-2.20.9-2.2-2.51.41.83.0-2.31.2
Ambulatory time after self-admin2.13.46.1-2.0-1.70.9-2.0-2.11.72.32.5-1.70.4
Bone: tissue strength0.10.10.2-0.3-0.30.1-0.3-0.4-0.40.4-0.10.0-0.2
Total heroin consumption0.70.82.91.00.60.11.20.8-0.7-1.7-0.6-0.10.8
Bone: trabecular number0.61.02.5-1.2-1.00.8-1.3-0.90.71.61.00.1-0.8
Bone: trabecular spacing0.10.10.4-0.3-0.10.2-0.4-0.20.50.60.00.2-0.6
Bone: trabecular thickness0.20.31.40.50.5-0.60.40.5-1.2-0.1-0.20.4-0.4
Bone: trabecular tissue density2.95.17.6-2.6-2.21.6-2.7-2.72.42.62.8-1.4-0.1
Water consumed over 24 hours0.91.82.9-1.7-1.61.2-1.6-1.61.21.51.2-0.80.2
Number of responses in last shaping day1.51.97.1-0.6-1.41.40.1-0.61.1-1.00.1-2.32.7