Hub : Genes

Aco1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Aco1 0.07 0.06 3.9e-05 0.04 0.03 0.04 0.04 2.1e-05 1.4e-04 3.8e-05 1.2e-05
2 Brain gene expression Aco1 0.26 0.1 4.4e-16 0.15 0.17 0.16 0.17 1.0e-13 9.9e-16 1.3e-14 2.5e-15
3 Adipose mRNA stability Aco1 0.1 0.05 6.8e-09 0.08 0.08 0.07 0.08 1.3e-09 2.3e-09 1.4e-08 2.6e-09
4 LHb gene expression Aco1 0.22 0.11 6.0e-05 0.14 0.13 0.11 0.13 3.7e-04 5.3e-04 1.7e-03 4.7e-04
5 PL mRNA stability Aco1 0.65 0.14 9.4e-12 0.11 0.11 0.11 0.11 6.4e-12 4.7e-12 3.6e-12 3.4e-12
6 BLA mRNA stability Aco1 0.12 0.08 1.3e-03 0.05 0.04 0.05 0.06 1.3e-03 2.4e-03 1.2e-03 6.7e-04
7 pVTA mRNA stability Aco1 0.14 0.08 2.7e-04 0.06 0.04 0.06 0.05 2.0e-05 2.1e-04 2.2e-05 4.8e-05
8 BLA gene expression Aco1 0.31 0.12 6.6e-13 0.25 0.2 0.22 0.22 9.9e-14 1.0e-10 5.0e-12 9.4e-12
9 NAcc gene expression Aco1 0.37 0.1 0.0e+00 0.18 0.16 0.17 0.18 1.5e-26 3.5e-23 2.0e-25 1.1e-26
10 NAcc mRNA stability Aco1 0.24 0.09 8.5e-15 0.11 0.1 0.11 0.11 1.2e-16 3.6e-14 3.0e-16 1.5e-16
11 Brain mRNA stability Aco1 0.3 0.12 0.0e+00 0.21 0.21 0.2 0.21 1.8e-19 2.5e-19 6.8e-19 2.8e-19
12 pVTA gene expression Aco1 0.51 0.11 0.0e+00 0.25 0.25 0.26 0.27 1.9e-20 7.7e-20 6.3e-21 1.8e-21

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.01.83.11.01.5-1.2-1.71.31.3-1.2-1.31.4-1.5-1.31.0
Area under the delay curve0.20.20.9-0.1-1.00.10.6-0.4-0.40.40.3-0.60.60.2-0.4
BMI with tail1.44.98.12.12.8-2.0-2.12.32.2-2.2-2.02.3-2.2-2.02.1
BMI without tail0.84.17.12.32.7-2.3-2.02.11.8-1.8-1.81.9-1.8-1.91.8
Body weight2.29.816.64.13.8-2.9-2.83.23.0-3.0-2.83.2-3.1-2.82.7
Weight adjusted by age0.00.10.40.60.30.40.4-0.0-0.20.20.20.1-0.10.2-0.1
Bone surface0.91.82.91.71.7-1.5-1.11.31.3-1.2-1.31.4-1.4-1.20.9
Bone volume0.61.11.71.11.3-1.3-1.21.00.9-0.8-1.01.0-1.2-1.00.7
Breakpoint value in progressive ratio session1.52.74.8-0.4-1.11.72.2-1.8-1.51.51.7-1.51.61.9-2.0
Number of licking bursts2.26.79.82.52.6-2.7-3.12.62.5-2.4-2.42.7-2.7-2.32.4
Context. condit. distance diff. score0.20.30.8-0.8-0.70.90.4-0.2-0.50.40.4-0.30.30.4-0.4
Locomotion velocity, session 11.31.52.40.4-1.51.30.6-1.2-1.31.31.3-1.31.11.3-1.4
Locomotion distance, session 10.60.81.40.1-1.10.90.2-0.8-1.01.01.1-0.90.81.1-1.2
Locomotion velocity, session 21.41.73.11.11.3-1.2-1.81.41.1-1.1-1.11.4-1.6-1.11.3
Locomotion distance, session 20.20.41.31.10.2-0.1-1.20.60.4-0.4-0.40.5-0.6-0.40.3
Locomotion velocity, session 31.11.23.8-0.6-1.01.90.5-1.1-1.01.01.0-1.11.11.1-1.3
Locomotion distance, session 30.10.10.60.80.40.3-0.60.30.3-0.2-0.10.1-0.1-0.30.0
Stereotopy head waving bouts, day 30.10.10.30.5-0.1-0.5-0.2-0.3-0.30.30.2-0.40.30.1-0.2
Stereotopy head waving duration, day 30.10.20.60.60.4-0.8-0.50.10.2-0.2-0.30.2-0.3-0.30.3
Locomotion velocity, session 70.40.50.7-0.7-0.50.70.3-0.7-0.70.70.7-0.80.60.8-0.7
Locomotion distance, session 70.60.71.7-0.8-0.81.3-0.2-0.8-0.80.80.9-0.80.80.8-0.8
Stereotopy head waving bouts, day 71.61.82.81.61.4-1.2-1.71.21.3-1.3-1.21.2-1.3-1.31.3
Stereotopy head waving duration, day 72.12.63.71.91.8-1.9-1.61.51.5-1.5-1.51.5-1.7-1.51.6
Locomotion velocity, session 80.50.71.80.0-1.31.0-0.1-0.7-0.90.80.9-0.70.61.0-0.7
Locomotion distance, session 80.40.72.0-0.2-1.21.4-0.0-0.5-0.90.80.8-0.70.60.7-0.7
Degree of sensitization distance0.40.51.1-1.0-1.00.60.4-0.7-0.70.70.7-0.50.50.7-0.5
Degree of sensitization stereotypy1.82.02.71.51.5-1.1-1.61.41.5-1.4-1.41.4-1.5-1.41.4
Conditioned locomotion0.70.81.7-0.2-0.90.80.5-1.0-1.00.90.8-0.90.71.0-1.3
Cocaine response after cond. corrected1.42.03.2-0.7-1.31.01.1-1.6-1.61.61.6-1.51.31.5-1.8
Cocaine response after cond. not corrected1.21.83.1-0.4-1.10.80.9-1.5-1.51.61.6-1.31.21.5-1.8
Cocaine response before conditioning1.21.41.71.31.3-1.1-1.21.21.3-1.2-1.21.3-1.1-1.11.2
Saline control response1.01.34.32.11.0-1.7-1.40.81.0-1.0-0.80.9-1.0-0.60.6
Bone: connectivity density0.71.22.00.81.4-1.0-1.01.11.1-1.0-1.11.3-1.2-1.00.8
Bone: cortical apparent density0.20.41.20.20.2-1.1-0.50.70.5-0.5-0.60.5-0.6-0.60.8
Bone: cortical area6.310.213.43.13.5-3.7-2.53.23.2-3.2-3.23.2-3.4-3.03.1
Bone: cortical porosity0.80.81.6-1.2-1.00.8-0.1-0.9-1.00.91.0-0.80.61.2-0.8
Bone: cortical porosity0.20.30.5-0.6-0.50.4-0.4-0.5-0.60.50.5-0.50.20.7-0.4
Bone: cortical thickness2.94.96.91.62.4-2.4-2.02.22.3-2.2-2.22.3-2.6-2.02.2
Bone: cortical thickness0.40.41.10.20.7-0.4-0.50.70.7-0.7-0.80.8-1.1-0.50.4
Bone: cortical tissue density0.10.21.00.10.1-1.0-0.40.50.3-0.3-0.40.3-0.4-0.50.6
Condit. Reinf. active minus inactive responses0.10.20.30.30.40.2-0.50.40.4-0.4-0.50.3-0.4-0.50.4
Condit. Reinf. active-inactive response ratio0.50.51.1-1.0-0.91.00.9-0.7-0.60.60.5-0.60.70.6-0.3
Condit. Reinf. active responses2.12.73.31.81.8-1.2-1.61.71.6-1.6-1.71.6-1.6-1.71.5
Condit. Reinf. inactive responses3.24.25.92.12.4-1.8-2.02.12.0-2.0-2.12.0-2.1-2.11.7
Incentive salience index mean1.82.33.61.91.6-0.9-1.91.51.5-1.5-1.61.4-1.3-1.51.3
Condit. Reinf. lever presses4.77.013.03.62.8-1.9-3.32.52.6-2.7-2.62.5-2.3-2.52.1
Condit. Reinf. active minus inactive responses1.32.02.41.41.5-1.5-1.01.31.5-1.5-1.51.4-1.3-1.51.4
Condit. Reinf. active-inactive response ratio0.10.10.2-0.00.4-0.2-0.40.20.4-0.3-0.40.4-0.3-0.30.4
Condit. Reinf. active responses2.94.25.02.22.1-2.2-1.52.02.1-2.1-2.12.0-1.8-2.12.1
Condit. Reinf. inactive responses4.16.07.02.42.6-2.6-1.72.52.5-2.5-2.52.4-2.4-2.62.5
Condit. Reinf. lever presses4.46.48.42.32.9-2.7-1.92.52.6-2.6-2.62.5-2.3-2.62.7
Condit. Reinf. lever reinforcers received3.55.05.82.42.3-2.3-1.62.12.3-2.3-2.32.2-2.0-2.32.3
Conditioned reinforcement - actives0.10.30.80.80.6-0.9-0.30.50.5-0.4-0.60.3-0.4-0.40.4
Conditioned reinforcement - inactives0.10.30.70.50.10.40.10.70.7-0.6-0.70.6-0.6-0.80.5
Conditioned locomotion0.20.31.2-0.4-0.71.10.1-0.6-0.20.40.2-0.50.40.4-0.5
Patch foraging indifference point 0 sec0.31.01.40.4-1.00.70.3-1.1-1.01.01.1-1.11.21.2-1.2
Patch foraging indifference point AUC3.37.810.83.33.1-2.5-1.92.92.9-2.9-2.82.8-3.0-2.62.6
Delay disc. indifference point, 0s delay0.80.81.4-0.7-1.21.00.4-1.0-0.90.90.9-1.01.01.0-0.9
Delay disc. indifference point, 16s delay0.40.52.30.3-0.90.31.5-0.5-0.60.60.4-0.90.90.2-0.6
Delay disc. indifference point, 2s delay0.20.31.50.10.2-1.2-0.70.30.1-0.1-0.30.0-0.1-0.50.7
Delay disc. indifference point, 24s delay0.10.10.60.1-0.7-0.50.3-0.0-0.10.10.0-0.40.30.1-0.2
Delay disc. indifference point, 4s delay0.00.00.2-0.2-0.40.10.20.00.1-0.1-0.10.0-0.1-0.20.1
Delay disc. indifference point, 8s delay0.10.10.30.4-0.1-0.5-0.20.30.4-0.4-0.50.2-0.3-0.40.3
Indifference point function ln k0.82.53.4-1.5-1.91.51.1-1.6-1.61.61.6-1.71.81.4-1.5
Indifference point function log k0.82.53.4-1.5-1.91.51.1-1.6-1.61.61.6-1.71.81.4-1.5
Patch foraging total patch changes 0 sec0.20.50.80.6-0.70.5-0.3-0.8-0.70.70.8-0.70.70.9-0.9
Patch foraging total patch changes 12 sec1.11.52.21.41.5-0.9-0.81.31.3-1.3-1.31.3-1.4-1.21.2
Patch foraging total patch changes 18 sec0.10.20.90.90.5-0.90.30.20.3-0.3-0.20.3-0.30.00.1
Patch foraging total patch changes 24 sec0.20.82.01.41.0-1.2-0.90.70.9-0.9-0.60.8-0.8-0.50.6
Patch foraging total patch changes 6 sec0.71.34.72.20.9-1.1-0.60.91.1-1.1-1.10.9-1.1-0.90.8
Patch foraging time to switch 0 sec0.31.33.4-1.9-1.21.21.5-1.0-0.90.90.8-1.11.30.6-0.8
Patch foraging water rate 0 sec0.10.31.41.20.5-0.4-0.90.40.3-0.3-0.30.6-0.7-0.10.3
Patch foraging water rate 12 sec0.00.10.20.1-0.20.3-0.3-0.1-0.40.40.3-0.30.00.4-0.2
Patch foraging water rate 18 sec0.41.02.20.41.1-1.0-1.51.01.0-0.9-0.80.9-1.0-0.81.1
Patch foraging water rate 24 sec0.10.10.8-0.5-0.1-0.2-0.90.30.1-0.0-0.10.2-0.2-0.10.2
Patch foraging water rate 6 sec0.60.93.40.80.4-0.6-1.80.90.8-0.8-0.80.9-1.0-0.60.7
Seeking ratio, delayed vs. immediate footshock0.71.01.70.91.00.3-0.91.01.0-1.0-1.31.2-1.1-1.00.9
Distance traveled before self-admin0.61.28.41.30.7-0.2-2.90.60.9-0.9-0.60.7-0.8-0.80.5
Distance traveled after self-admin2.95.09.71.91.7-2.1-3.12.32.3-2.3-2.12.3-2.4-2.02.1
Extensor digitorum longus weight5.622.528.05.35.0-4.9-4.44.84.7-4.7-4.84.7-4.6-4.64.5
Bone: elastic displacement4.75.99.7-3.1-2.52.12.5-2.2-2.52.52.5-2.42.12.5-2.2
Bone: elastic work0.81.04.3-2.1-0.40.00.7-0.9-1.01.01.1-0.90.61.2-0.8
Bone: endosteal estimation1.22.96.32.51.8-1.7-0.81.81.6-1.6-1.71.6-1.6-1.81.6
Bone: endosteal perimeter1.23.07.32.71.8-2.4-0.91.71.5-1.5-1.51.5-1.3-1.81.5
Epididymis fat weight0.10.30.80.50.7-0.5-0.90.50.6-0.6-0.40.6-0.4-0.50.5
Delta time in closed arm before/after self-admin0.50.41.70.40.3-1.3-0.10.70.4-0.4-0.70.4-0.4-1.00.9
Delta time in open arm before/after self-admin0.10.10.70.80.4-0.50.40.10.1-0.10.00.1-0.10.0-0.0
Diff in mean of infusions in LGA sessions0.30.51.10.00.8-0.40.40.80.7-0.7-0.81.0-1.0-0.50.9
Delay discount exponential model param0.10.20.90.10.9-0.1-0.60.40.4-0.4-0.20.5-0.5-0.20.4
Extinction: sum of active levers before priming1.11.72.8-1.4-1.51.71.4-1.3-1.11.11.1-1.11.01.4-1.3
Active lever presses in extinction session 60.10.10.40.20.2-0.60.4-0.2-0.20.20.2-0.20.20.2-0.2
Bone: final force2.03.24.91.92.0-2.2-1.91.71.6-1.6-1.61.6-2.0-1.41.6
Bone: final moment2.03.25.41.82.1-2.3-1.81.81.6-1.6-1.61.6-2.0-1.51.7
Food consumed during 24 hour testing period1.63.26.22.51.7-1.6-1.01.81.9-1.9-1.61.8-1.7-1.71.7
Glucose2.13.35.32.32.0-2.0-1.11.81.8-1.9-1.71.8-1.6-1.81.9
Heart weight1.52.54.71.92.2-1.9-0.41.41.7-1.7-1.51.5-1.5-1.21.2
Delay discount hyperbolic model param0.20.20.80.10.9-0.1-0.60.40.4-0.4-0.20.5-0.5-0.20.4
Intermittent access intake day 1-15 change0.63.55.71.91.8-2.4-0.31.91.9-1.9-2.21.7-1.8-2.01.9
Intermittent access intake escalation0.73.85.71.91.8-2.4-0.42.02.0-1.9-2.31.7-1.8-2.22.1
Intermittent access intake escalation 22.84.76.61.61.9-2.4-1.32.32.3-2.3-2.62.1-2.0-2.52.4
Intermitt. access day 1 inactive lever presses0.00.32.5-0.2-0.31.6-0.60.10.3-0.3-0.10.2-0.1-0.30.1
Intermitt. access day 15 inactive lever presses0.10.30.90.40.3-0.1-0.10.70.5-0.4-0.50.4-0.4-1.00.7
Intermitt. access escalation Index0.00.00.1-0.10.20.2-0.10.20.1-0.1-0.00.1-0.2-0.20.2
Intermittent access day 1 total infusions1.03.04.6-1.3-1.81.42.1-1.7-1.81.91.7-1.91.91.6-1.6
Intermittent access day 15 total infusions0.41.11.81.00.7-1.30.51.11.0-0.9-1.30.8-0.8-1.31.2
Intermittent access terminal intake (last 3 days)0.40.71.20.90.3-1.1-0.20.90.8-0.7-1.10.6-0.5-1.00.9
Intermittent access total infusions0.10.20.40.60.2-0.50.60.40.2-0.1-0.50.1-0.1-0.60.5
Intermittent access day 1 locomotion1.93.44.0-1.6-2.01.81.9-1.9-1.92.01.9-1.91.81.8-1.7
Intermittent access day 15 total locomotion0.31.15.5-0.5-0.90.32.3-0.9-0.90.90.8-1.00.90.8-0.7
Intermittent access total locomotion0.70.82.8-1.0-0.90.41.7-0.7-0.91.00.8-0.90.80.6-0.4
Intermittent access standard deviation0.10.41.00.90.2-0.30.00.70.5-0.4-1.00.4-0.4-1.00.7
Left kidney weight0.21.35.92.41.8-1.3-0.70.80.8-0.7-0.70.7-0.8-0.70.6
Right kidney weight0.42.97.02.62.6-2.5-0.41.51.3-1.3-1.21.3-1.4-1.31.4
Cocaine induced anxiety0.20.61.3-0.3-1.10.1-1.0-0.7-0.60.70.7-0.80.80.7-0.9
Post-drug Anxiety0.30.43.50.90.1-0.4-1.90.1-0.00.10.10.00.10.1-0.3
Baseline Anxiety1.32.24.11.52.0-0.9-1.11.61.4-1.4-1.41.7-1.6-1.41.4
Tail length0.95.18.83.02.4-2.5-2.02.32.1-2.1-2.12.1-2.1-2.21.9
Length with tail0.62.58.22.91.7-1.7-1.51.41.4-1.3-1.21.4-1.4-1.21.0
Length without tail0.00.10.70.80.00.1-0.0-0.2-0.00.10.20.0-0.20.3-0.2
Times rat made contact with spout0.20.30.70.20.5-0.3-0.90.70.4-0.4-0.30.7-0.8-0.40.4
Lifetime Intake0.10.20.70.80.1-0.30.60.40.2-0.1-0.50.0-0.1-0.60.4
Liver weight, left0.40.71.71.10.6-1.3-0.40.80.8-0.8-0.70.8-0.8-0.90.8
Liver weight, right0.10.11.1-0.10.1-0.41.10.0-0.00.10.20.1-0.10.2-0.3
Locomotor activity0.00.00.2-0.40.30.30.3-0.1-0.00.10.1-0.1-0.00.3-0.1
Locomotor testing distance0.10.20.4-0.1-0.30.60.6-0.3-0.30.30.2-0.30.20.4-0.6
Locomotor testing rearing0.31.01.31.01.0-0.1-0.51.11.1-1.1-1.11.1-1.1-1.00.7
Locomotion in novel chamber0.10.20.6-0.6-0.50.8-0.7-0.00.2-0.2-0.00.0-0.00.1-0.1
Locomotion in novel chamber post-restriction1.54.46.71.82.0-2.6-1.42.22.2-2.2-2.12.1-2.0-2.22.2
Fecal boli incidents, locomotor time 10.30.93.6-0.7-1.20.11.9-0.7-0.70.70.5-1.21.20.3-0.5
Change in fecal boli incidents, locomotor task0.30.32.0-0.3-0.21.4-0.3-0.4-0.50.50.6-0.1-0.00.6-0.5
Time >=10cm from walls, locomotor time 10.81.01.8-0.6-0.90.90.4-1.1-1.01.01.1-1.01.01.2-1.3
Bouts of movement, locomotor time 10.30.41.0-0.9-0.51.00.7-0.6-0.50.50.4-0.50.60.8-0.7
Total resting periods, locomotor time 10.60.61.4-1.2-0.60.81.0-0.7-0.70.70.5-0.70.80.9-0.7
Rest time, locomotor task time 10.20.32.0-1.4-0.1-0.50.2-0.3-0.40.40.2-0.40.60.4-0.1
Distance moved, locomotor task time 10.10.20.70.80.30.8-0.60.00.3-0.30.10.4-0.5-0.0-0.2
Vertical activity count, locomotor time 10.00.20.60.6-0.30.8-0.3-0.5-0.30.30.6-0.20.10.5-0.6
Time >=10cm from walls, locomotor time 20.41.02.3-0.9-1.31.50.1-1.1-0.70.70.9-1.01.11.0-1.1
Bouts of movement, locomotor time 21.55.07.22.71.7-2.4-0.52.42.3-2.3-2.52.1-2.2-2.52.3
Total resting periods, locomotor time 20.93.65.12.31.5-2.2-0.22.11.9-1.9-2.21.8-1.8-2.22.0
Rest time, locomotor task time 20.20.40.9-1.0-0.5-0.30.5-0.5-0.80.80.5-0.70.70.5-0.5
Distance moved, locomotor task time 20.10.10.4-0.40.40.6-0.5-0.10.4-0.40.10.3-0.40.00.1
Vertical activity count, locomotor time 20.00.10.20.1-0.20.4-0.2-0.3-0.10.10.4-0.20.10.2-0.2
Light reinforcement 10.41.86.82.61.7-0.9-0.31.21.2-1.2-1.31.1-1.1-1.20.9
Light reinforcement 20.10.21.91.40.40.20.1-0.2-0.30.30.3-0.10.30.3-0.4
Bone: marrow area1.43.46.32.51.9-1.9-0.91.91.8-1.7-1.81.8-1.8-1.91.8
Bone: maximum diameter4.59.014.13.33.3-3.8-2.32.82.9-2.9-3.02.8-2.8-2.93.0
Bone: maximum force3.87.410.12.93.2-3.2-2.92.62.5-2.5-2.52.6-2.9-2.42.5
Bone: maximum moment3.77.010.22.73.1-3.2-2.62.62.4-2.4-2.42.5-2.9-2.32.5
Mean time between licks in bursts0.00.10.70.2-0.0-0.30.9-0.2-0.20.20.2-0.1-0.10.2-0.3
Mean num. licks in bursts1.23.34.9-2.0-1.82.12.2-1.7-1.81.71.7-1.81.71.5-1.7
Cd content in liver3.74.15.12.12.1-2.3-1.52.02.1-2.1-2.12.1-1.9-2.02.0
Co content in liver0.20.21.40.2-0.2-0.11.2-0.3-0.30.30.2-0.30.20.5-0.7
Cu content in liver1.01.21.9-1.2-0.70.30.7-1.2-1.41.21.4-1.11.11.2-1.2
Fe content in liver0.81.01.50.1-1.2-0.11.2-1.0-1.01.01.0-1.01.21.1-1.1
K content in liver0.60.61.0-0.4-0.80.70.7-0.8-0.90.80.8-0.80.70.8-1.0
Mg content in liver1.41.62.4-1.1-1.00.91.1-1.3-1.41.31.4-1.21.11.5-1.6
Mn content in liver3.54.04.61.62.0-1.5-2.02.12.0-2.1-2.12.1-2.1-2.12.0
Na content in liver0.30.40.7-0.8-0.70.30.8-0.5-0.60.60.5-0.70.80.4-0.5
Rb content in liver3.84.46.9-2.1-2.02.12.6-2.2-2.01.91.9-2.12.12.1-2.0
Se content in liver4.35.06.31.72.3-1.4-2.42.42.4-2.5-2.42.4-2.3-2.32.2
Sr content in liver0.30.20.70.20.3-0.1-0.80.40.6-0.6-0.60.5-0.4-0.40.4
Zn content in liver0.10.10.4-0.00.7-0.6-0.40.10.1-0.1-0.10.2-0.20.1-0.0
Bone: minimum diameter0.30.61.80.71.0-1.30.10.70.7-0.6-0.60.7-0.9-0.60.7
Time in familiar zone, hab. session 10.60.71.0-0.61.0-0.8-0.80.80.9-0.9-0.90.8-0.7-0.90.8
Time in novel zone, hab. session 13.74.15.3-0.5-2.11.32.2-2.1-2.22.32.2-2.21.92.2-2.2
Total zone transitions, hab. session 10.71.01.8-1.3-1.21.3-0.2-1.0-1.01.01.1-0.90.61.3-0.9
Total locomotion distance, hab. session 10.30.42.2-0.60.5-0.0-1.50.50.4-0.4-0.30.5-0.7-0.20.5
Locomotion velocity, hab. session 10.91.34.40.31.1-0.7-2.11.11.0-1.1-1.01.1-1.3-0.91.2
Time in familiar zone, hab. session 20.10.20.7-0.70.8-0.60.30.20.2-0.2-0.30.20.1-0.30.4
Time in novel zone, hab. session 22.52.85.2-0.8-2.31.51.3-1.7-1.71.71.8-1.71.41.8-1.8
Total zone transitions, hab. session 20.20.31.40.2-0.61.2-0.6-0.3-0.40.40.4-0.30.20.4-0.6
Total locomotion distance, hab. session 20.40.51.70.80.6-0.5-1.30.80.6-0.6-0.70.6-0.5-0.70.7
Locomotion velocity, hab. session 20.50.62.10.80.6-0.6-1.40.80.6-0.6-0.70.6-0.6-0.80.8
Novel to familiar place preference ratio5.77.49.3-2.2-3.02.22.6-2.9-2.92.82.9-2.82.72.8-2.6
Novelty place preference6.98.911.0-2.6-3.32.52.8-3.2-3.13.13.2-3.12.93.1-2.8
Time in novel zone, NPP test8.410.212.3-2.8-3.52.83.1-3.4-3.33.33.4-3.23.13.3-3.0
Total zone transitions, NPP test0.10.20.50.2-0.30.7-0.6-0.3-0.40.40.4-0.30.10.6-0.6
Total locomotion distance, NPP test0.30.41.81.00.6-0.1-1.30.60.5-0.5-0.50.5-0.5-0.40.3
Locomotion velocity, NPP test0.50.72.51.10.8-0.5-1.60.90.7-0.7-0.80.7-0.7-0.70.6
Intraocular pressure0.81.32.31.41.3-1.5-1.31.01.1-1.1-0.61.2-1.3-0.50.8
Delta distance traveled before/after self-admin1.01.11.71.00.9-1.3-0.01.31.0-1.0-1.01.2-1.2-0.81.1
Delta ambulatory time before/after self-admin0.30.61.00.70.5-1.00.01.00.8-0.8-0.80.9-0.9-0.50.8
Parametrial fat weight0.10.31.00.3-0.50.81.0-0.4-0.40.40.4-0.20.30.5-0.7
Pavlov. Cond. lever latency4.65.89.3-3.0-2.31.83.1-2.3-2.42.52.4-2.42.12.2-2.1
Pavlov. Cond. magazine entry latency0.30.41.91.00.5-1.4-0.60.40.5-0.6-0.40.4-0.1-0.40.4
Pavlov. Cond. change in total contacts0.80.91.71.30.6-0.1-1.30.91.1-1.1-1.00.9-0.5-0.90.8
Pavlov. Cond. index score2.22.84.72.11.6-1.8-2.21.51.6-1.7-1.61.6-1.2-1.51.4
Pavlov. Cond. latency score1.92.54.22.01.5-1.7-2.01.41.6-1.6-1.51.5-1.1-1.41.3
Pavlov. Cond. lever contacts4.04.88.62.72.1-1.7-2.92.02.2-2.2-2.22.2-1.9-2.01.9
Pavlov. Cond. magazine entry number0.30.41.6-0.9-0.61.30.9-0.5-0.50.50.4-0.40.10.4-0.4
Pavlov. Cond. intertrial magazine entries0.20.30.50.30.5-0.1-0.20.60.5-0.5-0.50.6-0.7-0.60.6
Pavlov. Cond. lever-magazine prob. diff.2.32.94.72.01.7-1.9-2.21.51.7-1.7-1.61.6-1.2-1.51.5
Pavlov. Cond. response bias2.12.74.82.21.6-1.6-2.21.51.6-1.6-1.51.5-1.1-1.51.3
Pavlov. Cond. lever latency3.34.66.2-1.8-2.52.31.8-2.1-2.22.22.2-2.21.92.1-2.3
Pavlov. Cond. magazine entry latency0.10.10.90.10.3-1.00.20.00.1-0.1-0.1-0.00.5-0.10.3
Pavlov. Cond. change in total contacts0.92.33.40.81.8-1.7-1.31.51.7-1.7-1.71.4-1.0-1.61.8
Pavlov. Cond. index score0.71.12.30.61.3-1.5-0.71.01.0-1.0-1.01.0-0.5-1.01.2
Pavlov. Cond. latency score0.91.52.70.71.5-1.6-0.91.11.2-1.2-1.31.2-0.7-1.21.5
Pavlov. Cond. lever contacts2.63.85.81.72.3-2.4-1.61.92.0-2.0-2.02.0-1.6-1.92.1
Pavlov. Cond. magazine entry number0.40.61.5-0.1-1.01.20.7-0.7-0.70.70.7-0.60.30.7-0.9
Pavlov. Cond. intertrial magazine entries0.10.20.40.50.30.1-0.40.40.6-0.5-0.50.5-0.6-0.50.5
Pavlov. Cond. lever-magazine prob. diff.0.81.22.70.61.3-1.6-0.81.01.1-1.1-1.11.0-0.6-1.01.3
Pavlov. Cond. response bias1.41.93.81.01.7-1.9-1.31.31.4-1.4-1.31.3-1.0-1.31.5
Time in closed arm before self-admin0.20.30.6-0.70.00.80.6-0.6-0.30.30.7-0.40.30.8-0.5
Time in closed arm after self-admin0.00.10.5-0.7-0.00.3-0.1-0.10.1-0.10.10.0-0.10.00.1
Time in open arm before self-admin0.70.82.0-0.3-1.41.1-0.3-0.9-0.90.90.7-1.01.00.7-1.1
Time in open arm after self-admin0.30.42.11.50.4-0.5-0.30.50.5-0.5-0.60.5-0.4-0.50.3
Bone: periosteal estimation3.37.910.53.23.0-3.1-1.82.82.8-2.7-2.82.7-2.9-2.82.7
Bone: periosteal perimeter1.83.67.42.72.0-2.6-0.61.81.7-1.7-1.71.7-1.7-1.81.7
Bone: post-yield work2.74.78.83.02.4-2.5-1.72.12.0-2.0-2.12.0-1.8-2.22.0
Progressive ratio test 1 active lever presses0.30.60.9-0.3-0.80.80.8-0.6-0.90.90.7-0.90.90.4-0.6
Progressive ratio test 1 breakpoint0.20.40.7-0.1-0.80.70.7-0.4-0.70.80.6-0.70.80.3-0.5
Progressive ratio test 1 inactive lever presses0.00.10.70.8-0.00.50.30.30.2-0.1-0.20.1-0.1-0.40.1
Progressive ratio test 2 active lever presses0.20.21.90.7-0.4-0.21.40.1-0.20.3-0.1-0.30.3-0.1-0.2
Progressive ratio test 2 breakpoint0.20.32.00.7-0.4-0.21.40.0-0.20.3-0.1-0.40.4-0.1-0.2
Progressive ratio test 2 inactive lever presses0.10.30.60.70.3-0.10.40.70.5-0.4-0.50.4-0.5-0.80.5
Incentive Sensitization - Responses0.10.31.00.90.1-0.71.00.50.4-0.4-0.50.3-0.4-0.40.2
Incentive Sensitization - Breakpoint0.10.31.40.90.1-0.81.20.40.3-0.3-0.50.2-0.3-0.30.2
Sum of active levers in priming session hrs 5-62.12.04.5-0.5-1.51.12.1-1.4-1.51.51.4-1.31.21.4-1.5
Progressive ratio0.10.40.70.90.3-0.00.90.60.7-0.7-0.50.7-0.7-0.40.4
Food seeking constrained by brief footshock4.75.913.53.72.3-1.6-2.22.52.3-2.3-2.42.5-2.6-2.22.0
Seeking ratio, punishment vs. effort0.61.44.51.51.2-1.0-2.11.10.9-0.9-1.00.9-0.8-1.10.9
Retroperitoneal fat weight0.20.82.4-1.3-1.00.81.6-0.7-0.70.70.8-0.70.70.8-0.7
Reaction time number correct0.10.20.4-0.1-0.50.20.6-0.4-0.50.50.5-0.50.60.4-0.3
Reaction time mean minus median0.53.14.30.72.0-2.0-0.91.81.9-1.9-1.71.9-1.9-1.62.1
Reaction time mean minus median AUC0.74.65.81.22.3-2.2-1.32.12.4-2.3-2.12.4-2.4-2.02.4
Reaction time num false alarms0.50.92.00.41.2-1.4-0.30.91.0-1.0-0.90.8-0.8-1.01.0
Reaction time num false alarms AUC0.61.52.81.11.6-1.7-0.61.21.2-1.2-1.11.1-1.1-1.11.2
Reaction time trials correct on left0.10.20.4-0.1-0.50.20.6-0.4-0.50.50.5-0.50.60.4-0.3
Reaction time trials on left0.10.30.6-0.1-0.60.20.7-0.5-0.60.60.5-0.60.70.4-0.4
Reaction time mean0.10.21.0-0.80.1-1.00.7-0.0-0.00.10.20.1-0.10.30.3
Reaction time mean AUC0.10.21.0-0.90.0-1.00.6-0.1-0.10.20.20.0-0.00.30.3
Median of all reaction times0.61.02.0-1.3-0.9-0.31.4-0.9-1.01.01.0-0.80.81.1-0.6
Reaction time omissions0.71.14.4-0.7-0.2-0.22.1-0.9-1.11.11.1-1.11.10.9-0.9
Reaction time false alarm rate0.40.51.10.31.1-1.1-0.50.70.8-0.8-0.70.7-0.7-0.60.7
Reaction time premature initiation rate1.42.25.2-2.3-1.11.62.1-1.4-1.41.41.3-1.21.21.3-0.9
Reaction time premature initiations0.72.25.1-2.0-1.21.52.2-1.4-1.51.41.4-1.21.31.3-0.9
Std. dev. reaction times0.20.71.4-0.41.1-1.2-0.10.80.9-0.9-0.71.0-1.0-0.51.1
Reaction time trials completed0.10.30.6-0.1-0.60.20.7-0.5-0.60.60.5-0.60.70.4-0.4
Reaction time trials AUC0.10.30.5-0.2-0.60.30.7-0.6-0.60.60.6-0.60.70.5-0.4
Run reversals in cocaine runway, females0.40.52.2-0.80.01.50.10.40.6-0.6-0.40.7-0.7-0.40.5
Run reversals in cocaine runway, males0.40.41.1-1.0-0.21.00.2-0.6-0.50.50.7-0.40.50.6-0.6
Latency to leave start box in cocaine runway0.20.31.90.20.90.1-1.40.30.4-0.4-0.50.5-0.5-0.20.3
Latency to leave start box in cocaine runway, F0.60.71.4-0.6-0.30.90.3-1.1-0.90.90.8-0.80.71.2-1.1
Latency to leave start box in cocaine runway, M1.71.64.60.91.0-0.0-2.11.21.2-1.3-1.31.2-1.2-1.31.1
Std. dev. time between licks in bursts0.30.50.9-0.6-0.30.11.0-0.9-0.70.80.7-0.70.70.8-0.8
Total sessions with >9 infusions0.20.20.91.00.3-0.10.60.40.2-0.1-0.60.2-0.3-0.60.5
Short access day 1 total inactive lever presses0.20.32.50.8-0.91.60.00.1-0.00.1-0.0-0.0-0.1-0.3-0.2
Short access day 10 total inactive lever presses0.10.81.30.20.40.8-0.90.81.1-1.1-0.91.0-1.0-1.00.9
Short access day 1 total infusions0.10.20.90.9-0.20.50.60.20.00.0-0.3-0.1-0.1-0.30.0
Short access day 10 total infusions0.50.91.5-0.2-1.10.81.1-0.8-1.11.20.8-1.11.00.6-0.8
Short access total infusions0.20.21.00.7-0.50.31.0-0.0-0.50.5-0.0-0.50.4-0.2-0.2
Short access day 1 locomotion0.71.23.6-0.6-1.51.21.9-0.9-0.80.90.6-1.21.10.5-0.8
Short access day 10 total locomotion0.10.31.5-1.0-0.30.51.2-0.2-0.20.20.2-0.20.1-0.00.2
Short access total locomotion0.60.91.9-0.9-1.01.41.4-0.9-0.90.90.8-0.90.80.6-0.6
One hour access (0.3 mA shock)0.20.21.20.50.0-0.51.10.0-0.10.2-0.2-0.40.4-0.2-0.1
Compulsive drug intake0.00.10.6-0.2-0.2-0.8-0.30.10.0-0.10.1-0.20.2-0.10.1
One hour access (shock baseline)0.10.21.70.60.10.31.3-0.2-0.20.3-0.1-0.30.30.0-0.3
Social response proportion1.11.43.3-1.5-1.01.80.9-1.3-1.01.01.0-1.01.20.9-1.2
Social responses0.40.61.30.81.1-0.0-0.50.70.8-0.8-0.80.8-0.8-0.90.5
Social time0.10.20.91.00.3-0.80.80.20.2-0.2-0.20.2-0.2-0.30.0
Soleus weight0.20.62.01.4-0.3-1.01.1-0.6-0.40.40.5-0.60.80.6-0.6
Bone: stiffness5.09.011.33.23.4-3.0-3.02.92.9-2.9-3.03.0-3.1-2.82.8
Tibialis anterior weight6.120.932.85.74.5-4.9-4.64.54.4-4.4-4.44.4-4.4-4.34.1
Time to tail flick, vehicle, before self-admin0.40.41.5-1.00.10.31.2-0.7-0.40.40.7-0.50.70.6-0.4
Time to tail flick, vehicle, after self-admin1.02.12.81.21.7-1.7-0.11.41.6-1.6-1.51.5-1.4-1.41.6
Time to tail flick, test, before self-admin0.30.40.70.50.5-0.6-0.40.60.8-0.8-0.70.7-0.6-0.40.5
Time to tail flick, test, after self-admin0.60.73.00.20.8-1.7-1.00.70.7-0.7-0.40.7-0.6-0.50.7
Delta time to tail flick, vehicle, before/after SA1.81.93.41.81.0-1.8-0.71.41.3-1.3-1.41.3-1.3-1.41.2
Delta time to tail flick, test, before/after SA0.10.10.2-0.4-0.2-0.40.1-0.2-0.50.50.4-0.40.40.2-0.2
Tibia length0.30.93.51.90.7-1.2-0.40.90.7-0.8-0.70.9-1.0-0.90.9
Ambulatory time before self-admin0.30.86.11.00.20.3-2.50.50.7-0.7-0.60.5-0.5-0.80.3
Ambulatory time after self-admin1.62.55.21.91.0-1.2-2.31.61.6-1.6-1.51.6-1.7-1.41.3
Bone: tissue strength0.10.10.3-0.20.1-0.5-0.4-0.2-0.30.30.4-0.30.40.20.1
Total heroin consumption0.91.12.3-0.8-0.71.11.5-1.1-0.80.80.9-1.01.11.1-1.1
Bone: trabecular number0.71.32.30.91.3-1.2-1.51.11.1-1.1-1.11.2-1.3-1.00.9
Bone: trabecular spacing0.30.40.70.30.5-0.7-0.40.60.7-0.7-0.80.7-0.6-0.60.8
Bone: trabecular thickness0.40.60.9-0.9-0.80.50.0-0.7-0.90.90.8-0.80.40.8-0.9
Bone: trabecular tissue density2.64.67.12.11.9-1.2-2.72.22.2-2.2-2.22.3-2.4-2.12.0
Water consumed over 24 hours0.81.62.41.51.3-1.4-1.51.31.1-1.1-1.01.3-1.6-1.01.0
Number of responses in last shaping day0.30.31.81.4-0.20.20.7-0.4-0.60.60.4-0.50.40.2-0.6