Hub : Genes

Aco1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Aco1 0.07 0.06 3.9e-05 0.04 0.03 0.04 0.04 2.1e-05 1.4e-04 3.8e-05 1.2e-05
2 Brain gene expression Aco1 0.26 0.1 4.4e-16 0.15 0.17 0.16 0.17 1.0e-13 9.9e-16 1.3e-14 2.4e-15
3 Adipose mRNA stability Aco1 0.1 0.05 6.8e-09 0.08 0.08 0.07 0.08 1.3e-09 2.3e-09 1.4e-08 2.5e-09
4 LHb gene expression Aco1 0.22 0.11 6.0e-05 0.14 0.13 0.11 0.13 3.7e-04 5.3e-04 1.7e-03 4.7e-04
5 BLA mRNA stability Aco1 0.12 0.08 1.3e-03 0.05 0.04 0.05 0.06 1.3e-03 2.4e-03 1.2e-03 6.5e-04
6 pVTA mRNA stability Aco1 0.14 0.08 2.7e-04 0.06 0.04 0.06 0.05 2.0e-05 2.1e-04 2.0e-05 4.4e-05
7 BLA gene expression Aco1 0.31 0.12 6.6e-13 0.25 0.2 0.22 0.22 9.9e-14 1.0e-10 5.0e-12 1.0e-11
8 NAcc gene expression Aco1 0.37 0.1 0.0e+00 0.18 0.16 0.17 0.18 1.5e-26 3.5e-23 5.8e-25 1.2e-26
9 PL mRNA stability Aco1 0.65 0.14 9.4e-12 0.11 0.11 0.11 0.11 6.4e-12 4.7e-12 3.3e-12 3.5e-12
10 NAcc mRNA stability Aco1 0.24 0.09 8.5e-15 0.11 0.1 0.11 0.11 1.2e-16 3.6e-14 3.0e-16 1.4e-16
11 Brain mRNA stability Aco1 0.3 0.12 0.0e+00 0.21 0.21 0.2 0.21 1.8e-19 2.5e-19 6.8e-19 2.9e-19
12 pVTA gene expression Aco1 0.51 0.11 0.0e+00 0.25 0.25 0.26 0.27 1.9e-20 7.7e-20 6.3e-21 1.9e-21

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.11.93.21.01.51.21.71.31.21.31.41.81.51.31.0
Area under the delay curve0.20.20.9-0.1-1.0-0.1-0.6-0.4-0.4-0.3-0.6-0.4-0.6-0.2-0.4
BMI with tail1.44.78.12.12.82.02.12.22.22.02.31.72.22.02.1
BMI without tail1.33.97.12.32.72.32.01.81.81.81.91.31.81.91.8
Body weight2.29.416.64.13.82.92.83.03.02.83.22.43.12.82.7
Weight adjusted by age0.10.10.40.60.3-0.4-0.4-0.2-0.2-0.20.10.00.1-0.2-0.1
Bone surface1.12.03.21.71.71.51.11.31.21.31.41.81.41.21.0
Bone volume0.61.11.71.11.31.31.20.90.81.01.01.21.21.00.7
Breakpoint value in progressive ratio session2.32.74.8-0.4-1.1-1.7-2.2-1.5-1.5-1.7-1.5-1.8-1.6-1.9-2.0
Number of licking bursts4.06.59.82.52.62.73.12.52.42.42.72.12.72.32.4
Context. condit. distance diff. score0.20.30.8-0.8-0.7-0.9-0.4-0.5-0.4-0.4-0.3-0.3-0.3-0.4-0.4
Locomotion velocity, session 11.51.63.20.4-1.5-1.3-0.6-1.3-1.3-1.3-1.3-1.8-1.1-1.3-1.4
Locomotion distance, session 10.70.91.40.1-1.1-0.9-0.2-1.0-1.0-1.1-0.9-1.2-0.8-1.1-1.2
Locomotion velocity, session 21.41.63.11.11.31.21.81.11.11.11.40.91.61.11.3
Locomotion distance, session 20.20.31.31.10.20.11.20.40.40.40.50.10.60.40.3
Locomotion velocity, session 31.01.23.8-0.6-1.0-1.9-0.5-1.0-1.0-1.0-1.1-0.6-1.1-1.1-1.3
Locomotion distance, session 30.10.10.60.80.4-0.30.60.30.20.10.10.20.10.30.0
Stereotopy head waving bouts, day 30.10.10.30.5-0.10.50.2-0.3-0.3-0.2-0.4-0.4-0.3-0.1-0.2
Stereotopy head waving duration, day 30.10.20.60.60.40.80.50.20.20.30.20.40.30.30.3
Locomotion velocity, session 70.40.50.7-0.7-0.5-0.7-0.3-0.7-0.7-0.7-0.8-0.7-0.6-0.8-0.7
Locomotion distance, session 70.60.81.8-0.8-0.8-1.30.2-0.8-0.8-0.9-0.8-1.4-0.8-0.8-0.8
Stereotopy head waving bouts, day 71.61.82.81.61.41.21.71.31.31.21.21.11.31.31.3
Stereotopy head waving duration, day 72.22.73.71.91.81.91.61.51.51.51.51.71.71.51.6
Locomotion velocity, session 80.60.81.80.0-1.3-1.00.1-0.9-0.8-0.9-0.7-1.3-0.6-1.0-0.7
Locomotion distance, session 80.50.72.0-0.2-1.2-1.40.0-0.9-0.8-0.8-0.7-1.0-0.6-0.7-0.7
Degree of sensitization distance0.50.51.2-1.0-1.0-0.6-0.4-0.7-0.7-0.7-0.5-1.1-0.5-0.7-0.5
Degree of sensitization stereotypy1.92.02.71.51.51.11.61.51.41.41.41.31.51.41.4
Conditioned locomotion0.60.71.7-0.2-0.9-0.8-0.5-1.0-0.9-0.8-0.9-0.3-0.7-1.0-1.3
Cocaine response after cond. corrected1.61.93.2-0.7-1.3-1.0-1.1-1.6-1.6-1.6-1.5-1.2-1.3-1.5-1.8
Cocaine response after cond. not corrected1.41.73.1-0.4-1.1-0.8-0.9-1.5-1.6-1.6-1.3-1.2-1.2-1.5-1.8
Cocaine response before conditioning1.21.41.71.31.31.11.21.31.21.21.31.11.11.11.2
Saline control response1.01.34.32.11.01.71.41.01.00.80.90.51.00.60.6
Bone: connectivity density0.81.33.10.81.41.01.01.11.01.11.31.81.21.00.9
Bone: cortical apparent density0.20.31.20.20.21.10.50.50.50.60.50.40.60.60.8
Bone: cortical area6.510.013.43.13.53.72.53.23.23.23.22.83.43.03.1
Bone: cortical porosity0.80.91.6-1.2-1.0-0.80.1-1.0-0.9-1.0-0.8-1.3-0.6-1.2-0.9
Bone: cortical porosity0.30.31.2-0.6-0.5-0.40.4-0.6-0.5-0.5-0.5-1.1-0.2-0.7-0.5
Bone: cortical thickness2.94.86.91.62.42.42.02.32.22.22.31.92.62.02.2
Bone: cortical thickness0.50.61.80.20.70.40.50.70.70.80.81.41.10.50.4
Bone: cortical tissue density0.10.21.00.10.11.00.40.30.30.40.30.30.40.50.6
Condit. Reinf. active minus inactive responses0.10.20.30.30.4-0.20.50.40.40.50.30.50.40.50.4
Condit. Reinf. active-inactive response ratio0.50.51.1-1.0-0.9-1.0-0.9-0.6-0.6-0.5-0.6-0.4-0.7-0.6-0.3
Condit. Reinf. active responses2.12.63.31.81.81.21.61.61.61.71.61.71.61.71.5
Condit. Reinf. inactive responses3.44.25.92.12.41.82.02.02.02.12.02.12.12.11.7
Incentive salience index mean1.82.33.61.91.60.91.91.51.51.61.41.41.31.51.3
Condit. Reinf. lever presses5.07.013.03.62.81.93.32.62.72.62.52.52.32.52.1
Condit. Reinf. active minus inactive responses1.62.12.61.41.51.51.01.51.51.51.41.61.31.51.4
Condit. Reinf. active-inactive response ratio0.10.10.2-0.00.40.20.40.40.30.40.40.30.30.30.4
Condit. Reinf. active responses3.04.25.02.22.12.21.52.12.12.12.02.11.82.12.1
Condit. Reinf. inactive responses4.66.07.02.42.62.61.72.52.52.52.42.52.42.62.5
Condit. Reinf. lever presses4.56.28.42.32.92.71.92.62.62.62.52.12.32.62.7
Condit. Reinf. lever reinforcers received3.65.05.82.42.32.31.62.32.32.32.22.32.02.32.3
Conditioned reinforcement - actives0.20.41.30.80.60.90.30.50.40.60.31.10.40.40.4
Conditioned reinforcement - inactives0.30.40.90.50.1-0.4-0.10.70.60.70.60.90.60.80.5
Conditioned locomotion0.20.21.2-0.4-0.7-1.1-0.1-0.2-0.4-0.2-0.50.1-0.4-0.4-0.5
Patch foraging indifference point 0 sec0.61.12.80.4-1.0-0.7-0.3-1.0-1.0-1.1-1.1-1.7-1.2-1.2-1.2
Patch foraging indifference point AUC5.47.810.83.33.12.51.92.92.92.82.82.93.02.62.6
Delay disc. indifference point, 0s delay0.70.81.4-0.7-1.2-1.0-0.4-0.9-0.9-0.9-1.0-0.8-1.0-1.0-0.9
Delay disc. indifference point, 16s delay0.50.52.30.3-0.9-0.3-1.5-0.6-0.6-0.4-0.8-0.1-0.9-0.2-0.6
Delay disc. indifference point, 2s delay0.20.21.50.10.21.20.70.10.10.30.00.10.10.50.6
Delay disc. indifference point, 24s delay0.10.10.60.1-0.70.5-0.3-0.1-0.1-0.0-0.40.0-0.3-0.1-0.2
Delay disc. indifference point, 4s delay0.00.00.2-0.2-0.4-0.1-0.20.10.10.10.00.10.10.20.1
Delay disc. indifference point, 8s delay0.10.10.30.4-0.10.50.20.40.40.50.20.10.30.40.3
Indifference point function ln k1.42.43.4-1.5-1.9-1.5-1.1-1.6-1.6-1.6-1.7-1.4-1.8-1.4-1.5
Indifference point function log k1.42.43.4-1.5-1.9-1.5-1.1-1.6-1.6-1.6-1.7-1.4-1.8-1.4-1.5
Patch foraging total patch changes 0 sec0.30.61.70.6-0.7-0.50.3-0.7-0.7-0.8-0.7-1.3-0.7-0.9-0.9
Patch foraging total patch changes 12 sec1.21.52.21.41.50.90.81.31.31.31.31.01.41.21.2
Patch foraging total patch changes 18 sec0.10.20.90.90.50.9-0.30.30.30.20.30.10.3-0.00.1
Patch foraging total patch changes 24 sec0.50.82.01.41.01.20.90.90.90.60.80.20.80.50.6
Patch foraging total patch changes 6 sec0.81.24.72.20.91.10.61.11.11.10.90.61.10.90.8
Patch foraging time to switch 0 sec0.61.33.4-1.9-1.2-1.2-1.5-0.9-0.9-0.8-1.1-0.8-1.3-0.6-0.8
Patch foraging water rate 0 sec0.10.31.41.20.50.40.90.30.30.30.60.20.70.10.3
Patch foraging water rate 12 sec0.00.10.20.1-0.2-0.30.3-0.4-0.4-0.3-0.3-0.3-0.0-0.4-0.2
Patch foraging water rate 18 sec0.60.92.20.41.11.01.51.00.90.80.90.81.00.81.1
Patch foraging water rate 24 sec0.10.10.8-0.5-0.10.20.90.10.00.10.20.20.20.10.2
Patch foraging water rate 6 sec0.60.83.40.80.40.61.80.80.80.80.90.81.00.60.7
Seeking ratio, delayed vs. immediate footshock0.81.01.70.91.0-0.30.91.01.01.31.21.21.11.00.9
Distance traveled before self-admin0.91.28.41.30.70.22.90.90.90.60.70.50.80.80.5
Distance traveled after self-admin4.25.29.71.91.72.13.12.32.32.12.32.72.42.02.1
Extensor digitorum longus weight5.621.928.05.35.04.94.44.74.74.84.73.94.64.64.5
Bone: elastic displacement5.05.89.7-3.1-2.5-2.1-2.5-2.5-2.5-2.5-2.4-1.9-2.1-2.5-2.2
Bone: elastic work0.81.04.3-2.1-0.4-0.0-0.7-1.0-1.0-1.1-0.9-1.0-0.6-1.2-0.8
Bone: endosteal estimation1.32.96.32.51.81.70.81.61.61.71.61.71.61.81.6
Bone: endosteal perimeter1.42.97.32.71.82.40.91.51.51.51.51.31.31.81.5
Epididymis fat weight0.10.30.80.50.70.50.90.60.60.40.60.20.40.50.5
Delta time in closed arm before/after self-admin0.50.51.70.40.31.30.10.40.40.70.41.00.41.00.9
Delta time in open arm before/after self-admin0.10.10.70.80.40.5-0.40.10.1-0.00.10.10.1-0.0-0.0
Diff in mean of infusions in LGA sessions0.40.51.10.00.80.4-0.40.70.70.81.00.51.00.50.9
Delay discount exponential model param0.20.20.90.10.90.10.60.40.40.20.50.30.50.20.4
Extinction: sum of active levers before priming1.51.62.8-1.4-1.5-1.7-1.4-1.1-1.1-1.1-1.1-1.0-1.0-1.4-1.3
Active lever presses in extinction session 60.10.10.40.20.20.6-0.4-0.2-0.2-0.2-0.2-0.1-0.2-0.2-0.2
Bone: final force1.93.04.91.92.02.21.91.61.61.61.61.02.01.41.6
Bone: final moment1.93.05.41.82.12.31.81.61.61.61.61.12.01.51.7
Food consumed during 24 hour testing period2.33.16.22.51.71.61.01.91.91.61.81.81.71.71.7
Glucose2.13.35.32.32.02.01.11.81.91.71.81.81.61.81.9
Heart weight1.62.44.71.92.21.90.41.71.71.51.51.11.51.21.2
Delay discount hyperbolic model param0.20.20.80.10.90.10.60.40.40.20.50.30.50.20.4
Intermittent access intake day 1-15 change1.83.86.61.91.82.40.31.91.92.21.72.61.82.01.9
Intermittent access intake escalation1.93.96.01.91.82.40.42.01.92.31.72.51.82.22.1
Intermittent access intake escalation 24.34.97.61.61.92.41.32.32.32.62.12.82.02.52.4
Intermitt. access day 1 inactive lever presses0.10.32.5-0.2-0.3-1.60.60.30.30.10.2-0.30.10.30.1
Intermitt. access day 15 inactive lever presses0.10.30.90.40.30.10.10.50.40.50.40.60.41.00.7
Intermitt. access escalation Index0.00.10.4-0.10.2-0.20.10.10.10.00.1-0.60.20.20.2
Intermittent access day 1 total infusions1.93.14.6-1.3-1.8-1.4-2.1-1.8-1.9-1.7-1.9-2.0-1.9-1.6-1.6
Intermittent access day 15 total infusions0.71.11.81.00.71.3-0.51.00.91.30.81.20.81.31.2
Intermittent access terminal intake (last 3 days)0.50.71.20.90.31.10.20.80.71.10.61.10.51.00.9
Intermittent access total infusions0.10.20.40.60.20.5-0.60.20.10.50.10.30.10.60.4
Intermittent access day 1 locomotion2.83.65.2-1.6-2.0-1.8-1.9-1.9-2.0-1.9-1.9-2.3-1.8-1.8-1.7
Intermittent access day 15 total locomotion0.51.05.5-0.5-0.9-0.3-2.3-0.9-0.9-0.8-1.0-0.4-0.9-0.8-0.7
Intermittent access total locomotion0.70.82.8-1.0-0.9-0.4-1.7-0.9-1.0-0.8-0.9-0.7-0.8-0.6-0.4
Intermittent access standard deviation0.30.52.30.90.20.3-0.00.50.41.00.41.50.41.00.7
Left kidney weight0.31.25.92.41.81.30.70.80.70.70.70.00.80.70.6
Right kidney weight0.62.87.02.62.62.50.41.31.31.21.31.01.41.31.4
Cocaine induced anxiety0.40.61.3-0.3-1.1-0.11.0-0.6-0.7-0.7-0.8-0.6-0.8-0.7-0.9
Post-drug Anxiety0.40.43.50.90.10.41.9-0.0-0.1-0.10.00.1-0.1-0.1-0.3
Baseline Anxiety1.92.24.11.52.00.91.11.41.41.41.71.71.61.41.4
Tail length1.35.08.83.02.42.52.02.12.12.12.12.02.12.21.9
Length with tail0.52.48.22.91.71.71.51.41.31.21.41.01.41.21.0
Length without tail0.00.10.70.80.0-0.10.0-0.0-0.1-0.20.0-0.30.2-0.3-0.2
Times rat made contact with spout0.20.30.70.20.50.30.90.40.40.30.70.50.80.40.4
Lifetime Intake0.10.20.70.80.10.3-0.60.20.10.50.00.30.10.60.4
Liver weight, left0.40.71.71.10.61.30.40.80.80.70.80.70.80.90.8
Liver weight, right0.10.11.1-0.10.10.4-1.1-0.0-0.1-0.20.10.30.1-0.2-0.3
Locomotor activity0.00.00.2-0.40.3-0.3-0.3-0.0-0.1-0.1-0.1-0.20.0-0.3-0.1
Locomotor testing distance0.10.20.4-0.1-0.3-0.6-0.6-0.3-0.3-0.2-0.3-0.3-0.2-0.4-0.6
Locomotor testing rearing0.51.01.31.01.00.10.51.11.11.11.11.11.11.00.7
Locomotion in novel chamber0.20.31.1-0.6-0.5-0.80.70.20.20.00.0-1.10.0-0.1-0.1
Locomotion in novel chamber post-restriction2.64.26.71.82.02.61.42.22.22.12.11.52.02.22.2
Fecal boli incidents, locomotor time 10.60.83.6-0.7-1.2-0.1-1.9-0.7-0.7-0.5-1.2-0.0-1.2-0.3-0.5
Change in fecal boli incidents, locomotor task0.40.42.0-0.3-0.2-1.40.3-0.5-0.5-0.6-0.1-1.00.0-0.6-0.5
Time >=10cm from walls, locomotor time 11.01.01.9-0.6-0.9-0.9-0.4-1.0-1.0-1.1-1.0-1.4-1.0-1.2-1.3
Bouts of movement, locomotor time 10.40.41.0-0.9-0.5-1.0-0.7-0.5-0.5-0.4-0.50.2-0.6-0.8-0.7
Total resting periods, locomotor time 10.50.61.4-1.2-0.6-0.8-1.0-0.7-0.7-0.5-0.70.1-0.8-0.9-0.8
Rest time, locomotor task time 10.20.32.0-1.4-0.10.5-0.2-0.4-0.4-0.2-0.4-0.6-0.6-0.4-0.1
Distance moved, locomotor task time 10.10.20.70.80.3-0.80.60.30.3-0.10.40.40.50.0-0.1
Vertical activity count, locomotor time 10.10.20.60.6-0.3-0.80.3-0.3-0.3-0.6-0.2-0.4-0.1-0.5-0.6
Time >=10cm from walls, locomotor time 20.71.12.3-0.9-1.3-1.5-0.1-0.7-0.7-0.9-1.0-1.2-1.1-1.0-1.1
Bouts of movement, locomotor time 23.25.18.02.71.72.40.52.32.32.52.12.82.22.52.3
Total resting periods, locomotor time 22.23.86.42.31.52.20.21.91.92.21.82.51.82.22.0
Rest time, locomotor task time 20.30.40.9-1.0-0.50.3-0.5-0.8-0.8-0.5-0.70.1-0.7-0.5-0.5
Distance moved, locomotor task time 20.10.10.4-0.40.4-0.60.50.40.4-0.10.3-0.40.4-0.00.1
Vertical activity count, locomotor time 20.10.10.50.1-0.2-0.40.2-0.1-0.1-0.4-0.2-0.7-0.1-0.2-0.2
Light reinforcement 10.71.86.82.61.70.90.31.21.21.31.11.21.11.20.9
Light reinforcement 20.20.21.91.40.4-0.2-0.1-0.3-0.3-0.3-0.1-0.3-0.3-0.3-0.4
Bone: marrow area1.53.46.32.51.91.90.91.81.71.81.81.91.81.91.8
Bone: maximum diameter4.78.814.13.33.33.82.32.92.93.02.82.42.82.93.0
Bone: maximum force4.07.110.12.93.23.22.92.52.52.52.61.82.92.42.5
Bone: maximum moment3.96.710.22.73.13.22.62.42.42.42.51.82.92.32.5
Mean time between licks in bursts0.00.10.70.2-0.00.3-0.9-0.2-0.2-0.2-0.10.30.1-0.2-0.3
Mean num. licks in bursts2.03.24.9-2.0-1.8-2.1-2.2-1.8-1.7-1.7-1.8-1.3-1.7-1.5-1.7
Cd content in liver3.53.95.12.12.12.31.52.12.12.12.11.51.92.02.0
Co content in liver0.20.21.40.2-0.20.1-1.2-0.3-0.3-0.2-0.30.3-0.2-0.5-0.7
Cu content in liver0.91.11.9-1.2-0.7-0.3-0.7-1.4-1.2-1.4-1.1-0.6-1.1-1.2-1.2
Fe content in liver0.81.01.50.1-1.20.1-1.2-1.0-1.0-1.0-1.0-0.7-1.2-1.1-1.1
K content in liver0.60.61.0-0.4-0.8-0.7-0.7-0.9-0.8-0.8-0.8-0.7-0.7-0.8-1.0
Mg content in liver1.51.52.4-1.1-1.0-0.9-1.1-1.4-1.3-1.4-1.2-1.1-1.1-1.5-1.6
Mn content in liver3.74.16.21.62.01.52.02.02.12.12.12.52.12.12.0
Na content in liver0.40.40.7-0.8-0.7-0.3-0.8-0.6-0.6-0.5-0.7-0.4-0.8-0.4-0.5
Rb content in liver3.74.36.9-2.1-2.0-2.1-2.6-2.0-1.9-1.9-2.1-1.8-2.1-2.1-2.0
Se content in liver4.35.16.31.72.31.42.42.42.52.42.42.52.32.32.2
Sr content in liver0.20.20.70.20.30.10.80.60.60.60.5-0.10.40.40.4
Zn content in liver0.10.10.4-0.00.70.60.40.10.10.10.20.40.2-0.1-0.0
Bone: minimum diameter0.30.61.80.71.01.3-0.10.70.60.60.70.60.90.60.7
Time in familiar zone, hab. session 10.80.71.2-0.61.00.80.80.90.90.90.81.10.70.90.8
Time in novel zone, hab. session 14.14.15.3-0.5-2.1-1.3-2.2-2.2-2.3-2.2-2.2-2.2-1.9-2.2-2.2
Total zone transitions, hab. session 10.81.12.1-1.3-1.2-1.30.2-1.0-1.0-1.1-0.9-1.4-0.6-1.3-0.9
Total locomotion distance, hab. session 10.30.42.2-0.60.50.01.50.40.40.30.50.30.70.20.5
Locomotion velocity, hab. session 10.91.34.40.31.10.72.11.01.11.01.10.81.30.91.2
Time in familiar zone, hab. session 20.20.20.7-0.70.80.6-0.30.20.20.30.20.3-0.10.30.4
Time in novel zone, hab. session 22.82.85.2-0.8-2.3-1.5-1.3-1.7-1.7-1.8-1.7-2.0-1.4-1.8-1.8
Total zone transitions, hab. session 20.20.31.40.2-0.6-1.20.6-0.4-0.4-0.4-0.3-0.3-0.2-0.4-0.6
Total locomotion distance, hab. session 20.40.51.70.80.60.51.30.60.60.70.60.70.50.70.7
Locomotion velocity, hab. session 20.40.62.10.80.60.61.40.60.60.70.60.70.60.80.8
Novel to familiar place preference ratio7.17.712.2-2.2-3.0-2.2-2.6-2.9-2.8-2.9-2.8-3.5-2.7-2.8-2.6
Novelty place preference8.69.314.6-2.6-3.3-2.5-2.8-3.1-3.1-3.2-3.1-3.8-2.9-3.1-2.8
Time in novel zone, NPP test9.910.616.6-2.8-3.5-2.8-3.1-3.3-3.3-3.4-3.2-4.1-3.1-3.3-3.0
Total zone transitions, NPP test0.20.20.60.3-0.3-0.70.6-0.4-0.4-0.4-0.3-0.8-0.1-0.6-0.6
Total locomotion distance, NPP test0.30.41.81.00.60.11.30.50.50.50.50.10.50.40.3
Locomotion velocity, NPP test0.50.72.51.10.80.51.60.70.70.80.70.60.70.70.6
Intraocular pressure0.91.22.31.41.31.51.31.11.10.61.20.41.30.50.8
Delta distance traveled before/after self-admin1.11.12.21.00.91.30.01.01.01.01.21.51.20.81.1
Delta ambulatory time before/after self-admin0.50.61.60.70.51.0-0.00.80.80.80.91.30.90.50.8
Parametrial fat weight0.10.31.00.3-0.5-0.8-1.0-0.4-0.4-0.4-0.20.2-0.3-0.5-0.7
Pavlov. Cond. lever latency4.65.89.3-3.0-2.3-1.8-3.1-2.4-2.5-2.4-2.4-2.3-2.1-2.2-2.1
Pavlov. Cond. magazine entry latency0.30.41.91.00.51.40.60.50.60.40.40.70.10.40.4
Pavlov. Cond. change in total contacts0.90.91.71.30.60.11.31.11.11.00.91.10.50.90.8
Pavlov. Cond. index score2.22.84.72.11.61.82.21.61.71.61.61.71.21.51.4
Pavlov. Cond. latency score2.02.54.22.01.51.72.01.61.61.51.51.61.11.41.3
Pavlov. Cond. lever contacts4.04.88.62.72.11.72.92.22.22.22.22.11.92.02.0
Pavlov. Cond. magazine entry number0.40.51.6-0.9-0.6-1.3-0.9-0.5-0.5-0.4-0.4-0.8-0.1-0.4-0.4
Pavlov. Cond. intertrial magazine entries0.20.20.50.30.50.10.20.50.50.50.60.10.70.60.6
Pavlov. Cond. lever-magazine prob. diff.2.43.04.72.01.71.92.21.71.71.61.61.81.21.51.5
Pavlov. Cond. response bias2.22.74.82.21.61.62.21.61.61.51.51.71.11.51.4
Pavlov. Cond. lever latency3.34.56.2-1.8-2.5-2.3-1.8-2.2-2.2-2.2-2.2-1.9-1.9-2.1-2.3
Pavlov. Cond. magazine entry latency0.10.10.90.10.31.0-0.20.10.10.1-0.00.1-0.50.10.3
Pavlov. Cond. change in total contacts1.42.33.40.81.81.71.31.71.71.71.41.41.01.61.8
Pavlov. Cond. index score0.81.02.30.61.31.50.71.01.01.01.00.80.51.01.2
Pavlov. Cond. latency score1.11.52.70.71.51.60.91.21.21.31.21.10.71.21.5
Pavlov. Cond. lever contacts2.73.75.81.72.32.41.62.02.02.02.01.61.61.92.0
Pavlov. Cond. magazine entry number0.50.61.5-0.1-1.0-1.2-0.7-0.7-0.7-0.7-0.6-0.7-0.3-0.7-0.9
Pavlov. Cond. intertrial magazine entries0.20.20.40.50.3-0.10.40.60.50.50.50.60.60.50.5
Pavlov. Cond. lever-magazine prob. diff.0.91.12.70.61.31.60.81.11.11.11.00.90.61.01.3
Pavlov. Cond. response bias1.41.93.81.01.71.91.31.41.41.31.31.01.01.31.5
Time in closed arm before self-admin0.30.41.2-0.70.0-0.8-0.6-0.3-0.3-0.7-0.4-1.1-0.3-0.8-0.5
Time in closed arm after self-admin0.10.10.5-0.7-0.0-0.30.10.10.1-0.10.0-0.40.1-0.00.1
Time in open arm before self-admin0.70.82.0-0.3-1.4-1.10.3-0.9-0.9-0.7-1.0-0.7-1.0-0.7-1.1
Time in open arm after self-admin0.30.42.11.50.40.50.30.50.50.60.50.70.40.50.3
Bone: periosteal estimation3.77.710.53.23.03.11.82.82.72.82.72.52.92.82.7
Bone: periosteal perimeter2.13.57.42.72.02.60.61.71.71.71.71.71.71.81.7
Bone: post-yield work3.24.68.83.02.42.51.72.02.02.12.01.91.82.22.0
Progressive ratio test 1 active lever presses0.50.61.1-0.3-0.8-0.8-0.8-0.9-0.9-0.7-0.9-1.0-0.9-0.4-0.6
Progressive ratio test 1 breakpoint0.40.50.8-0.1-0.8-0.7-0.7-0.7-0.8-0.6-0.7-0.9-0.8-0.3-0.5
Progressive ratio test 1 inactive lever presses0.10.10.70.8-0.0-0.5-0.30.20.10.20.10.00.10.40.1
Progressive ratio test 2 active lever presses0.20.31.90.7-0.40.2-1.4-0.2-0.30.1-0.30.4-0.30.1-0.2
Progressive ratio test 2 breakpoint0.20.32.00.7-0.40.2-1.4-0.2-0.30.1-0.40.4-0.40.1-0.2
Progressive ratio test 2 inactive lever presses0.20.30.70.70.30.1-0.40.50.40.50.40.80.50.80.5
Incentive Sensitization - Responses0.20.31.00.90.10.7-1.00.40.40.50.30.90.40.40.2
Incentive Sensitization - Breakpoint0.30.41.40.90.10.8-1.20.30.30.50.20.90.30.30.2
Sum of active levers in priming session hrs 5-62.01.94.5-0.5-1.5-1.1-2.1-1.5-1.5-1.4-1.3-0.6-1.2-1.4-1.5
Progressive ratio0.20.40.70.90.30.0-0.90.70.70.50.70.70.70.40.4
Food seeking constrained by brief footshock4.85.913.53.72.31.62.22.32.32.42.52.42.62.22.0
Seeking ratio, punishment vs. effort0.91.34.51.51.21.02.10.90.91.00.90.90.81.10.9
Retroperitoneal fat weight0.20.82.4-1.3-1.0-0.8-1.6-0.7-0.7-0.8-0.7-0.4-0.7-0.8-0.7
Reaction time number correct0.10.20.4-0.1-0.5-0.2-0.6-0.5-0.5-0.5-0.5-0.5-0.6-0.4-0.3
Reaction time mean minus median1.33.24.60.72.02.00.91.91.91.71.92.11.91.62.1
Reaction time mean minus median AUC1.84.76.01.22.32.21.32.42.32.12.42.52.42.02.4
Reaction time num false alarms0.60.92.00.41.21.40.31.01.00.90.80.80.81.01.0
Reaction time num false alarms AUC0.91.42.81.11.61.70.61.21.21.11.11.01.11.11.2
Reaction time trials correct on left0.10.20.4-0.1-0.5-0.2-0.6-0.5-0.5-0.5-0.5-0.5-0.6-0.4-0.3
Reaction time trials on left0.10.30.6-0.1-0.6-0.2-0.7-0.6-0.6-0.5-0.6-0.6-0.7-0.4-0.4
Reaction time mean0.10.21.0-0.80.11.0-0.7-0.0-0.1-0.20.1-0.10.1-0.30.3
Reaction time mean AUC0.10.21.0-0.90.01.0-0.6-0.1-0.2-0.20.0-0.10.0-0.30.3
Median of all reaction times0.71.02.0-1.3-0.90.3-1.4-1.0-1.0-1.0-0.8-1.1-0.8-1.1-0.6
Reaction time omissions0.81.14.4-0.7-0.20.2-2.1-1.1-1.1-1.1-1.1-0.7-1.1-0.9-0.9
Reaction time false alarm rate0.40.51.10.31.11.10.50.80.80.70.70.50.70.60.7
Reaction time premature initiation rate1.62.25.2-2.3-1.1-1.6-2.1-1.4-1.4-1.3-1.2-1.1-1.2-1.3-0.9
Reaction time premature initiations1.22.25.1-2.0-1.2-1.5-2.2-1.5-1.4-1.4-1.2-1.1-1.3-1.3-0.9
Std. dev. reaction times0.40.71.4-0.41.11.20.10.90.90.71.00.91.00.51.1
Reaction time trials completed0.10.30.6-0.1-0.6-0.2-0.7-0.6-0.6-0.5-0.6-0.6-0.7-0.4-0.4
Reaction time trials AUC0.20.30.5-0.2-0.6-0.3-0.7-0.6-0.6-0.6-0.6-0.7-0.7-0.5-0.4
Run reversals in cocaine runway, females0.50.52.2-0.80.0-1.5-0.10.60.60.40.7-0.40.70.40.5
Run reversals in cocaine runway, males0.40.41.1-1.0-0.2-1.0-0.2-0.5-0.5-0.7-0.4-0.7-0.5-0.6-0.6
Latency to leave start box in cocaine runway0.30.31.90.20.9-0.11.40.40.40.50.5-0.40.50.20.3
Latency to leave start box in cocaine runway, F0.70.82.1-0.6-0.3-0.9-0.3-0.9-0.9-0.8-0.8-1.4-0.7-1.2-1.1
Latency to leave start box in cocaine runway, M1.61.54.60.91.00.02.11.21.31.31.20.61.21.31.1
Std. dev. time between licks in bursts0.40.50.9-0.6-0.3-0.1-1.0-0.7-0.8-0.7-0.7-0.7-0.7-0.8-0.8
Total sessions with >9 infusions0.20.20.91.00.30.1-0.60.20.10.60.20.20.30.60.5
Short access day 1 total inactive lever presses0.30.32.50.8-0.9-1.6-0.0-0.0-0.10.0-0.00.10.10.3-0.2
Short access day 10 total inactive lever presses0.30.81.30.20.4-0.80.91.11.10.91.00.81.01.00.9
Short access day 1 total infusions0.10.20.90.9-0.2-0.5-0.60.0-0.00.3-0.10.40.10.30.0
Short access day 10 total infusions0.70.91.5-0.2-1.1-0.8-1.1-1.1-1.2-0.8-1.1-1.2-1.0-0.6-0.8
Short access total infusions0.20.21.00.7-0.5-0.3-1.0-0.5-0.50.0-0.5-0.2-0.40.2-0.2
Short access day 1 locomotion0.91.13.6-0.6-1.5-1.2-1.9-0.8-0.9-0.6-1.2-0.4-1.1-0.5-0.8
Short access day 10 total locomotion0.10.31.5-1.0-0.3-0.5-1.2-0.2-0.2-0.2-0.2-0.2-0.10.00.2
Short access total locomotion0.81.01.9-0.9-1.0-1.4-1.4-0.9-0.9-0.8-0.9-1.1-0.8-0.6-0.6
One hour access (0.3 mA shock)0.20.21.20.50.00.5-1.1-0.1-0.20.2-0.40.3-0.40.2-0.1
Compulsive drug intake0.10.10.6-0.2-0.20.80.30.00.1-0.1-0.2-0.0-0.20.10.1
One hour access (shock baseline)0.10.21.70.60.1-0.3-1.3-0.2-0.30.1-0.30.2-0.3-0.0-0.3
Social response proportion1.21.33.3-1.5-1.0-1.8-0.9-1.0-1.0-1.0-1.0-0.8-1.2-0.9-1.2
Social responses0.50.71.60.81.10.00.50.80.80.80.81.30.80.90.5
Social time0.20.20.91.00.30.8-0.80.20.20.20.20.50.20.30.0
Soleus weight0.20.62.01.4-0.31.0-1.1-0.4-0.4-0.5-0.6-0.5-0.8-0.6-0.6
Bone: stiffness5.48.811.33.23.43.03.02.92.93.03.02.33.12.82.8
Tibialis anterior weight6.020.332.85.74.54.94.64.44.44.44.43.44.44.34.1
Time to tail flick, vehicle, before self-admin0.50.51.5-1.00.1-0.3-1.2-0.4-0.4-0.7-0.5-0.9-0.7-0.6-0.4
Time to tail flick, vehicle, after self-admin1.62.22.81.21.71.70.11.61.61.51.51.51.41.41.6
Time to tail flick, test, before self-admin0.30.40.70.50.50.60.40.80.80.70.70.50.60.40.5
Time to tail flick, test, after self-admin0.60.63.00.20.81.71.00.70.70.40.7-0.00.60.50.7
Delta time to tail flick, vehicle, before/after SA2.12.03.41.81.01.80.71.31.31.41.31.81.31.41.3
Delta time to tail flick, test, before/after SA0.10.10.3-0.4-0.20.4-0.1-0.5-0.5-0.4-0.4-0.5-0.4-0.2-0.2
Tibia length0.30.93.51.90.71.20.40.70.80.70.90.51.00.90.9
Ambulatory time before self-admin0.60.86.11.00.2-0.32.50.70.70.60.50.50.50.80.3
Ambulatory time after self-admin2.22.65.21.91.01.22.31.61.61.51.61.91.71.41.3
Bone: tissue strength0.20.21.8-0.20.10.50.4-0.3-0.3-0.4-0.3-1.3-0.4-0.20.1
Total heroin consumption0.91.02.3-0.8-0.7-1.1-1.5-0.8-0.8-0.9-1.0-1.1-1.1-1.1-1.1
Bone: trabecular number0.81.42.30.91.31.21.51.11.11.11.21.41.31.00.9
Bone: trabecular spacing0.30.40.70.30.50.70.40.70.70.80.70.10.60.60.8
Bone: trabecular thickness0.40.60.9-0.9-0.8-0.5-0.0-0.9-0.9-0.8-0.8-0.5-0.4-0.8-0.9
Bone: trabecular tissue density3.14.67.12.11.91.22.72.22.22.22.32.22.42.12.0
Water consumed over 24 hours1.21.62.41.51.31.41.51.11.11.01.31.11.61.01.0
Number of responses in last shaping day0.30.41.81.4-0.2-0.2-0.7-0.6-0.6-0.4-0.5-0.5-0.4-0.2-0.6