Hub : Genes

Aco1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Aco1 0.05 0.04 8.3e-05 0.03 0.03 0.04 0.04 1.0e-04 1.4e-04 5.7e-05 6.6e-05
2 LHb gene expression Aco1 0.23 0.11 3.6e-05 0.14 0.13 0.12 0.14 3.1e-04 5.9e-04 1.1e-03 4.3e-04
3 BLA gene expression Aco1 0.28 0.12 9.9e-13 0.26 0.21 0.24 0.23 2.9e-14 2.1e-11 4.9e-13 1.2e-12
4 BLA mRNA stability Aco1 0.13 0.09 1.0e-03 0.05 0.05 0.06 0.06 9.3e-04 1.2e-03 6.9e-04 4.6e-04
5 NAcc mRNA stability Aco1 0.25 0.1 1.7e-14 0.15 0.12 0.14 0.14 5.1e-17 2.9e-13 3.7e-16 5.8e-16
6 PL mRNA stability Aco1 0.48 0.15 3.4e-11 0.12 0.12 0.12 0.12 6.3e-13 5.5e-13 1.3e-12 5.0e-13
7 Brain gene expression Aco1 0.21 0.09 4.4e-16 0.18 0.18 0.17 0.17 1.3e-16 1.6e-16 4.3e-16 9.1e-16
8 pVTA gene expression Aco1 0.41 0.15 5.6e-07 0.22 0.16 0.19 0.2 6.4e-10 2.0e-07 1.2e-08 3.3e-09
9 Brain mRNA stability Aco1 0.29 0.11 0.0e+00 0.22 0.19 0.21 0.21 1.9e-20 4.8e-17 3.1e-19 1.9e-19
10 NAcc gene expression Aco1 0.34 0.1 0.0e+00 0.21 0.2 0.22 0.22 6.5e-24 2.0e-22 1.3e-24 1.5e-24
11 Adipose mRNA stability Aco1 0.1 0.05 7.3e-09 0.08 0.08 0.07 0.08 2.3e-09 2.1e-09 1.0e-08 2.3e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density1.01.62.6-1.2-1.6-1.31.3-1.31.2-1.3-1.3-1.1-1.30.9
Area under the delay curve0.30.30.60.30.80.3-0.30.6-0.50.70.60.20.7-0.5
BMI with tail1.34.35.4-2.2-2.0-1.92.0-2.22.1-2.3-2.2-1.9-2.12.0
BMI without tail1.83.69.3-3.1-2.0-1.81.7-1.71.8-1.7-1.6-1.8-1.51.8
Body weight1.77.214.6-3.8-2.7-2.52.5-2.62.6-2.7-2.6-2.5-2.62.1
Weight adjusted by age0.30.42.2-0.40.10.7-0.50.4-0.50.40.40.60.0-1.5
Bone surface0.71.22.8-1.7-0.9-1.11.1-1.11.1-1.1-1.1-0.9-1.00.4
Bone volume0.40.71.4-1.2-1.1-0.80.8-0.70.7-0.7-0.7-0.7-0.70.7
Breakpoint value in progressive ratio session0.70.81.6-0.11.30.9-0.70.8-0.70.80.81.00.7-1.2
Number of licking bursts5.86.89.9-2.6-3.1-2.62.6-2.62.6-2.6-2.6-2.5-2.52.4
Context. condit. distance diff. score0.20.20.70.80.30.4-0.40.4-0.40.40.40.40.4-0.3
Locomotion velocity, session 11.71.84.7-0.00.61.4-1.41.4-1.41.41.41.31.4-2.2
Locomotion distance, session 10.70.91.60.20.11.0-1.01.0-1.01.01.01.01.0-1.3
Locomotion velocity, session 21.01.12.0-1.0-1.4-0.90.9-1.01.0-1.0-1.0-1.0-0.91.3
Locomotion distance, session 20.20.31.2-0.9-1.1-0.40.4-0.50.4-0.5-0.5-0.4-0.5-0.2
Locomotion velocity, session 30.81.04.60.40.50.9-0.90.8-0.90.80.80.90.6-2.2
Locomotion distance, session 30.40.41.1-1.1-0.7-0.50.5-0.60.5-0.6-0.6-0.5-0.8-0.7
Stereotopy head waving bouts, day 30.10.10.3-0.6-0.10.3-0.30.3-0.30.30.30.30.50.0
Stereotopy head waving duration, day 30.10.10.3-0.6-0.3-0.10.1-0.00.1-0.0-0.0-0.10.10.5
Locomotion velocity, session 70.10.10.50.30.70.3-0.30.3-0.30.30.30.30.3-0.4
Locomotion distance, session 70.20.20.90.50.10.3-0.30.4-0.40.40.40.40.2-1.0
Stereotopy head waving bouts, day 72.52.84.8-2.2-2.1-1.61.6-1.51.6-1.5-1.5-1.6-1.51.5
Stereotopy head waving duration, day 71.51.84.0-2.0-1.5-1.21.3-1.21.2-1.2-1.2-1.3-1.01.4
Locomotion velocity, session 80.81.01.20.40.11.1-1.11.1-1.11.11.11.11.1-1.1
Locomotion distance, session 80.30.51.70.50.00.7-0.70.7-0.70.70.70.70.6-1.3
Degree of sensitization distance0.60.61.31.20.70.7-0.70.8-0.80.80.80.70.8-0.1
Degree of sensitization stereotypy1.31.42.5-1.6-1.6-1.11.1-1.11.1-1.1-1.1-1.1-1.11.0
Conditioned locomotion0.80.92.50.30.60.9-0.90.9-1.00.91.00.90.9-1.6
Cocaine response after cond. corrected2.22.53.20.81.41.7-1.71.6-1.71.61.71.81.6-1.6
Cocaine response after cond. not corrected2.02.23.10.51.11.7-1.61.5-1.61.51.61.81.6-1.5
Cocaine response before conditioning1.31.62.3-1.5-1.4-1.21.2-1.31.2-1.3-1.3-1.2-1.21.2
Saline control response0.81.03.8-1.9-1.4-0.70.8-0.80.8-0.8-0.8-0.8-0.60.8
Bone: connectivity density0.91.41.7-1.1-1.1-1.21.3-1.31.2-1.3-1.3-0.9-1.30.7
Bone: cortical apparent density0.20.22.00.3-0.2-0.20.2-0.20.2-0.2-0.2-0.2-0.01.4
Bone: cortical area3.95.96.8-2.6-2.1-2.52.5-2.42.5-2.4-2.4-2.5-2.32.6
Bone: cortical porosity0.91.01.51.20.11.1-1.11.1-1.21.11.11.11.2-0.1
Bone: cortical porosity0.30.30.40.6-0.40.6-0.60.6-0.60.60.60.60.60.1
Bone: cortical thickness1.93.14.7-1.4-1.7-1.71.8-1.81.7-1.8-1.8-1.7-1.72.2
Bone: cortical thickness0.10.10.20.1-0.2-0.40.5-0.40.4-0.4-0.4-0.5-0.50.3
Bone: cortical tissue density0.10.21.60.4-0.1-0.10.0-0.00.1-0.0-0.10.00.11.3
Condit. Reinf. active minus inactive responses0.20.20.4-0.5-0.5-0.50.5-0.60.5-0.6-0.6-0.4-0.60.0
Condit. Reinf. active-inactive response ratio0.50.51.21.10.80.7-0.70.6-0.70.60.60.80.6-0.6
Condit. Reinf. active responses2.53.13.9-2.0-1.6-1.81.8-1.91.8-1.9-1.9-1.7-1.91.0
Condit. Reinf. inactive responses4.25.05.7-2.4-2.1-2.32.3-2.32.3-2.3-2.3-2.3-2.41.6
Incentive salience index mean2.02.44.3-2.1-1.7-1.51.5-1.61.5-1.6-1.6-1.5-1.60.7
Condit. Reinf. lever presses4.96.613.6-3.7-3.0-2.42.4-2.42.5-2.4-2.4-2.4-2.51.1
Condit. Reinf. active minus inactive responses1.21.52.1-1.4-0.6-1.41.3-1.31.3-1.3-1.2-1.4-1.20.8
Condit. Reinf. active-inactive response ratio0.10.10.2-0.0-0.2-0.40.3-0.30.3-0.3-0.2-0.5-0.30.4
Condit. Reinf. active responses2.53.55.2-2.3-1.2-2.02.0-1.91.9-1.9-1.9-2.0-1.81.4
Condit. Reinf. inactive responses4.55.66.8-2.6-1.7-2.42.5-2.42.5-2.4-2.4-2.4-2.42.1
Condit. Reinf. lever presses3.64.95.5-2.3-1.3-2.32.3-2.32.3-2.3-2.3-2.3-2.12.3
Condit. Reinf. lever reinforcers received3.04.26.2-2.5-1.3-2.22.2-2.12.1-2.1-2.1-2.2-2.01.5
Conditioned reinforcement - actives0.40.40.6-0.6-0.5-0.60.5-0.80.6-0.7-0.7-0.7-0.50.8
Conditioned reinforcement - inactives0.91.11.8-0.60.1-1.01.1-1.11.1-1.3-1.2-1.3-1.2-0.4
Conditioned locomotion0.00.10.20.4-0.50.00.0-0.10.00.1-0.1-0.2-0.1-0.4
Patch foraging indifference point 0 sec0.61.03.0-0.60.31.1-1.00.9-1.01.00.91.10.9-1.7
Patch foraging indifference point AUC4.95.68.0-2.8-1.8-2.52.5-2.52.5-2.4-2.5-2.5-2.51.2
Delay disc. indifference point, 0s delay0.91.01.41.00.50.9-0.91.1-1.11.21.10.91.1-0.9
Delay disc. indifference point, 16s delay0.60.61.8-0.11.40.4-0.60.9-0.70.90.90.20.9-1.1
Delay disc. indifference point, 2s delay0.20.21.7-0.0-0.8-0.30.10.1-0.00.30.1-0.30.21.3
Delay disc. indifference point, 24s delay0.10.10.40.20.60.1-0.20.2-0.10.10.30.00.40.2
Delay disc. indifference point, 4s delay0.00.00.20.40.4-0.20.2-0.10.10.0-0.1-0.2-0.0-0.1
Delay disc. indifference point, 8s delay0.10.10.1-0.10.1-0.40.4-0.20.3-0.1-0.2-0.4-0.10.3
Indifference point function ln k1.62.22.81.41.31.5-1.61.7-1.51.61.61.31.6-1.1
Indifference point function log k1.62.22.81.41.31.5-1.61.7-1.51.61.61.31.6-1.1
Patch foraging total patch changes 0 sec0.30.61.7-0.9-0.30.7-0.70.5-0.70.70.60.80.5-1.3
Patch foraging total patch changes 12 sec1.31.62.3-1.5-0.8-1.31.4-1.51.3-1.3-1.4-1.2-1.40.5
Patch foraging total patch changes 18 sec0.20.21.1-1.10.2-0.40.6-0.40.3-0.3-0.4-0.3-0.30.0
Patch foraging total patch changes 24 sec0.60.72.9-1.7-0.9-0.91.0-0.60.6-0.5-0.6-0.7-0.60.6
Patch foraging total patch changes 6 sec0.81.14.1-2.0-0.7-1.11.1-1.00.9-0.8-1.0-0.8-1.0-0.1
Patch foraging time to switch 0 sec0.71.14.32.11.50.7-0.70.9-0.90.91.00.80.9-0.4
Patch foraging water rate 0 sec0.20.21.5-1.2-0.7-0.00.1-0.30.2-0.2-0.3-0.1-0.3-0.4
Patch foraging water rate 12 sec0.10.10.1-0.4-0.30.2-0.30.3-0.20.30.20.20.2-0.3
Patch foraging water rate 18 sec0.60.82.2-0.7-1.5-0.70.7-0.80.7-0.9-0.8-0.7-0.91.3
Patch foraging water rate 24 sec0.10.20.80.3-0.90.10.00.00.0-0.0-0.10.1-0.10.9
Patch foraging water rate 6 sec0.71.03.8-1.2-1.9-0.90.8-0.80.8-0.8-0.9-0.8-0.80.8
Seeking ratio, delayed vs. immediate footshock1.21.42.6-1.0-1.6-1.31.1-1.11.1-1.2-1.1-1.2-1.30.2
Distance traveled before self-admin1.21.35.5-1.5-2.3-1.01.1-0.70.8-0.6-0.7-1.1-1.1-0.3
Distance traveled after self-admin3.74.15.6-1.6-2.4-2.32.2-2.12.1-2.1-2.1-1.7-2.21.2
Extensor digitorum longus weight5.923.030.8-5.6-4.4-4.84.9-4.95.0-4.9-4.9-4.9-4.73.7
Bone: elastic displacement3.94.48.32.92.32.1-2.12.0-2.12.02.12.02.0-1.2
Bone: elastic work0.81.13.11.80.80.9-0.90.8-0.90.80.80.91.11.2
Bone: endosteal estimation0.61.33.8-2.0-0.6-1.21.1-1.01.2-1.0-1.0-1.3-0.90.4
Bone: endosteal perimeter0.71.55.3-2.3-0.7-1.21.1-1.01.2-1.0-1.0-1.3-0.90.8
Epididymis fat weight0.30.62.1-1.5-1.2-0.50.6-0.70.6-0.6-0.7-0.5-0.70.3
Delta time in closed arm before/after self-admin1.61.61.9-1.0-1.0-1.31.2-1.31.3-1.1-1.4-1.4-1.21.4
Delta time in open arm before/after self-admin0.20.20.9-0.40.90.2-0.20.4-0.20.30.40.10.40.0
Diff in mean of infusions in LGA sessions0.10.10.90.31.0-0.10.0-0.20.3-0.2-0.30.2-0.3-0.2
Delay discount exponential model param0.20.20.8-0.3-0.9-0.20.3-0.50.4-0.6-0.5-0.2-0.60.5
Extinction: sum of active levers before priming0.60.61.31.21.00.7-0.60.7-0.60.60.70.80.6-0.9
Active lever presses in extinction session 60.60.61.20.30.60.6-0.81.0-0.81.10.90.60.90.0
Bone: final force1.01.63.1-1.6-1.7-1.11.1-1.11.0-1.1-1.1-1.0-0.91.8
Bone: final moment0.91.53.8-1.5-1.5-1.11.1-1.01.0-1.0-1.1-1.0-0.81.9
Food consumed during 24 hour testing period2.22.74.7-2.2-0.9-1.81.8-1.71.7-1.7-1.7-1.7-1.70.3
Glucose1.11.62.9-1.7-0.9-1.31.3-1.31.3-1.3-1.3-1.2-1.40.3
Heart weight1.52.23.9-2.0-1.2-1.71.6-1.41.5-1.3-1.4-1.6-1.31.2
Delay discount hyperbolic model param0.30.30.7-0.4-0.8-0.20.4-0.50.5-0.7-0.6-0.2-0.60.5
Intermittent access intake day 1-15 change1.61.63.3-0.90.2-1.81.3-1.11.2-0.9-1.1-1.7-0.81.8
Intermittent access intake escalation1.81.83.4-1.20.5-1.91.5-1.31.3-1.1-1.3-1.7-1.11.1
Intermittent access intake escalation 22.12.13.5-1.0-0.6-1.91.6-1.41.5-1.2-1.4-1.8-1.31.7
Intermitt. access day 1 inactive lever presses0.10.21.10.4-0.30.3-0.00.3-0.30.20.2-0.1-0.0-1.0
Intermitt. access day 15 inactive lever presses0.10.10.5-0.0-0.1-0.30.2-0.10.2-0.3-0.2-0.7-0.3-0.6
Intermitt. access escalation Index0.20.20.3-0.6-0.2-0.40.4-0.50.3-0.6-0.5-0.4-0.3-0.1
Intermittent access day 1 total infusions1.82.13.11.21.41.8-1.71.3-1.51.31.41.31.5-1.3
Intermittent access day 15 total infusions0.20.31.0-0.31.0-0.60.4-0.40.4-0.4-0.4-0.8-0.20.1
Intermittent access terminal intake (last 3 days)0.30.30.7-0.6-0.0-0.70.5-0.50.6-0.5-0.5-0.8-0.40.2
Intermittent access total infusions0.10.10.2-0.20.3-0.20.0-0.30.2-0.3-0.2-0.5-0.2-0.3
Intermittent access day 1 locomotion4.34.56.22.31.92.5-2.32.1-2.22.02.12.22.1-1.6
Intermittent access day 15 total locomotion1.71.84.81.32.21.2-1.31.3-1.31.31.31.01.3-1.0
Intermittent access total locomotion1.01.12.91.71.41.1-1.10.8-0.90.90.90.70.9-0.5
Intermittent access standard deviation0.70.71.6-0.50.0-1.10.8-0.90.9-0.8-0.9-1.3-0.90.2
Left kidney weight0.20.75.9-2.4-0.5-0.60.4-0.30.4-0.3-0.3-0.6-0.30.4
Right kidney weight0.20.64.8-2.20.2-0.50.4-0.20.3-0.2-0.3-0.5-0.10.6
Cocaine induced anxiety2.12.43.51.30.51.7-1.71.9-1.71.71.81.61.9-0.6
Post-drug Anxiety0.30.30.80.1-0.90.6-0.60.7-0.60.50.70.50.60.2
Baseline Anxiety2.32.53.5-1.1-1.1-1.61.5-1.81.7-1.8-1.8-1.6-1.91.0
Tail length0.72.27.2-2.7-1.8-1.41.3-1.11.3-1.0-1.1-1.4-1.11.3
Length with tail0.20.74.2-2.0-1.1-0.50.5-0.40.5-0.4-0.5-0.5-0.60.2
Length without tail0.20.51.60.50.50.9-0.60.5-0.70.60.50.90.3-1.3
Times rat made contact with spout0.20.20.9-0.3-0.9-0.40.4-0.40.3-0.4-0.4-0.3-0.40.7
Lifetime Intake0.20.20.6-0.80.2-0.40.2-0.50.4-0.5-0.4-0.6-0.3-0.5
Liver weight, left0.91.41.8-1.3-1.3-1.11.2-1.21.2-1.2-1.2-1.1-1.11.0
Liver weight, right0.00.00.2-0.40.40.00.00.0-0.10.0-0.10.00.2-0.2
Locomotor activity0.00.00.10.10.2-0.10.1-0.0-0.0-0.1-0.10.2-0.1-0.2
Locomotor testing distance0.10.10.7-0.30.4-0.0-0.0-0.1-0.1-0.1-0.10.2-0.2-0.8
Locomotor testing rearing0.61.01.5-1.1-0.6-1.01.1-1.21.0-1.2-1.1-0.9-1.2-0.2
Locomotion in novel chamber0.20.21.50.5-1.20.10.2-0.10.0-0.0-0.10.10.00.7
Locomotion in novel chamber post-restriction4.65.67.3-1.8-2.0-2.32.6-2.42.5-2.5-2.4-2.4-2.22.7
Fecal boli incidents, locomotor time 11.11.22.81.01.70.6-0.81.2-1.11.31.20.31.4-0.6
Change in fecal boli incidents, locomotor task0.30.31.6-0.3-1.30.4-0.2-0.30.2-0.5-0.30.4-0.5-0.6
Time >=10cm from walls, locomotor time 10.80.81.40.40.51.0-1.01.0-1.00.91.01.21.0-0.5
Bouts of movement, locomotor time 10.50.51.61.00.80.4-0.50.6-0.60.60.50.50.4-1.2
Total resting periods, locomotor time 10.60.61.71.31.10.5-0.60.7-0.70.70.70.60.6-0.9
Rest time, locomotor task time 10.50.62.81.30.40.3-0.40.6-0.40.50.50.20.71.7
Distance moved, locomotor task time 10.40.42.1-1.0-0.60.10.3-0.50.3-0.3-0.50.2-0.7-1.5
Vertical activity count, locomotor time 10.30.31.7-0.8-0.50.4-0.1-0.1-0.10.0-0.00.6-0.2-1.3
Time >=10cm from walls, locomotor time 20.80.81.20.80.30.8-0.71.1-1.01.01.10.91.1-0.8
Bouts of movement, locomotor time 23.74.06.6-2.1-0.6-2.42.2-2.12.1-2.2-2.1-2.6-1.81.1
Total resting periods, locomotor time 22.72.95.1-1.7-0.3-2.21.9-1.71.8-1.8-1.7-2.3-1.51.0
Rest time, locomotor task time 20.40.50.80.90.80.5-0.90.8-0.70.80.80.40.80.1
Distance moved, locomotor task time 20.10.10.20.3-0.30.10.4-0.40.3-0.3-0.40.3-0.50.0
Vertical activity count, locomotor time 20.00.00.2-0.2-0.30.40.0-0.0-0.10.00.00.40.1-0.1
Light reinforcement 11.32.37.1-2.7-0.2-1.61.6-1.41.5-1.3-1.4-1.6-1.6-0.7
Light reinforcement 20.30.42.4-1.60.10.1-0.00.10.10.00.0-0.1-0.2-1.3
Bone: marrow area0.71.64.0-2.0-0.7-1.31.3-1.11.3-1.1-1.2-1.5-1.10.6
Bone: maximum diameter2.95.48.8-3.0-2.1-2.32.3-2.22.3-2.2-2.2-2.4-2.02.4
Bone: maximum force2.84.97.3-2.7-2.6-2.12.1-2.12.1-2.1-2.1-2.0-1.92.5
Bone: maximum moment2.54.46.6-2.4-2.3-2.02.0-2.01.9-2.0-2.0-1.9-1.72.6
Mean time between licks in bursts0.10.20.80.00.90.4-0.40.4-0.40.40.40.30.5-0.3
Mean num. licks in bursts3.13.75.02.12.21.9-1.91.9-1.91.91.91.91.8-1.6
Cd content in liver2.52.75.0-1.3-1.3-1.71.7-1.71.7-1.7-1.7-1.7-1.42.2
Co content in liver0.40.41.40.21.20.5-0.50.5-0.50.50.50.50.6-0.9
Cu content in liver0.20.20.40.60.30.4-0.40.4-0.40.40.40.40.50.7
Fe content in liver0.20.22.3-1.50.30.2-0.10.1-0.10.10.10.20.4-0.2
K content in liver0.70.71.60.70.60.9-0.90.8-0.80.80.80.90.7-1.3
Mg content in liver1.21.31.41.11.01.2-1.21.2-1.11.21.21.21.1-0.8
Mn content in liver1.41.62.0-0.8-1.4-1.31.3-1.31.4-1.4-1.3-1.3-1.41.0
Na content in liver0.40.40.90.90.70.6-0.60.6-0.60.60.60.60.6-0.3
Rb content in liver3.64.47.42.12.72.0-2.02.1-2.12.02.12.02.0-1.9
Se content in liver4.75.87.2-1.8-2.2-2.52.5-2.62.6-2.6-2.6-2.5-2.71.6
Sr content in liver0.50.40.9-0.3-1.0-0.60.6-0.60.7-0.6-0.6-0.6-0.60.8
Zn content in liver0.10.10.40.1-0.4-0.30.3-0.30.3-0.4-0.3-0.3-0.40.6
Bone: minimum diameter0.00.10.6-0.20.4-0.20.2-0.10.2-0.1-0.1-0.3-0.00.7
Time in familiar zone, hab. session 11.11.03.40.4-0.6-0.90.9-0.91.0-0.9-0.9-1.0-0.91.8
Time in novel zone, hab. session 14.44.35.00.72.02.2-2.22.1-2.22.12.12.22.2-2.2
Total zone transitions, hab. session 10.50.71.51.20.30.8-0.80.9-0.90.90.90.80.8-0.6
Total locomotion distance, hab. session 10.40.61.60.3-1.3-0.70.7-0.70.7-0.7-0.7-0.7-0.81.0
Locomotion velocity, hab. session 11.11.63.4-0.5-1.9-1.21.2-1.21.2-1.2-1.2-1.2-1.31.5
Time in familiar zone, hab. session 20.30.31.00.30.5-0.40.4-0.50.5-0.5-0.5-0.5-0.51.0
Time in novel zone, hab. session 23.53.54.41.21.12.0-2.02.0-2.02.02.02.12.1-1.8
Total zone transitions, hab. session 20.20.31.5-0.1-0.40.4-0.40.4-0.40.40.40.40.3-1.2
Total locomotion distance, hab. session 20.40.61.8-0.7-1.3-0.70.7-0.70.7-0.7-0.7-0.7-0.80.5
Locomotion velocity, hab. session 20.50.72.0-0.8-1.4-0.70.7-0.70.8-0.7-0.7-0.7-0.80.7
Novel to familiar place preference ratio6.76.98.02.32.42.7-2.72.8-2.82.82.82.82.8-2.1
Novelty place preference8.38.49.62.72.63.0-3.03.0-3.13.03.03.03.1-2.2
Time in novel zone, NPP test9.49.710.92.92.83.2-3.23.2-3.33.23.23.23.3-2.5
Total zone transitions, NPP test0.20.20.6-0.2-0.60.4-0.40.4-0.40.40.40.40.3-0.8
Total locomotion distance, NPP test0.40.51.7-1.0-1.3-0.60.6-0.60.6-0.6-0.6-0.6-0.7-0.1
Locomotion velocity, NPP test0.60.92.5-1.2-1.6-0.80.8-0.80.9-0.8-0.8-0.8-1.00.2
Intraocular pressure0.60.92.7-1.7-0.7-0.70.9-0.90.9-1.0-0.8-0.8-0.80.7
Delta distance traveled before/after self-admin0.40.40.8-0.4-0.2-0.70.6-0.80.8-0.9-0.8-0.1-0.60.6
Delta ambulatory time before/after self-admin0.20.20.50.00.0-0.60.5-0.60.6-0.7-0.60.1-0.60.2
Parametrial fat weight0.20.30.9-0.0-0.00.6-0.70.6-0.50.50.60.60.4-0.9
Pavlov. Cond. lever latency5.16.510.53.22.82.5-2.52.5-2.52.52.52.52.6-1.3
Pavlov. Cond. magazine entry latency0.10.20.7-0.8-0.4-0.20.2-0.30.2-0.3-0.3-0.2-0.20.8
Pavlov. Cond. change in total contacts1.51.62.3-1.5-1.2-1.31.3-1.41.3-1.4-1.4-1.3-1.5-0.2
Pavlov. Cond. index score2.12.74.6-2.1-1.8-1.51.5-1.61.6-1.6-1.6-1.5-1.61.3
Pavlov. Cond. latency score1.82.34.1-2.0-1.6-1.51.5-1.51.5-1.5-1.5-1.4-1.41.3
Pavlov. Cond. lever contacts3.54.16.5-2.6-2.2-2.02.0-2.02.0-2.0-2.0-2.0-2.01.2
Pavlov. Cond. magazine entry number0.30.41.01.00.70.5-0.50.5-0.50.50.50.40.4-0.8
Pavlov. Cond. intertrial magazine entries0.20.30.3-0.4-0.4-0.50.5-0.50.5-0.5-0.5-0.6-0.60.3
Pavlov. Cond. lever-magazine prob. diff.2.12.63.8-2.0-1.7-1.51.5-1.61.6-1.6-1.6-1.5-1.51.5
Pavlov. Cond. response bias1.72.14.1-2.0-1.6-1.31.3-1.41.3-1.4-1.4-1.3-1.41.0
Pavlov. Cond. lever latency3.14.25.72.01.52.1-2.12.1-2.12.12.12.11.9-2.4
Pavlov. Cond. magazine entry latency0.10.10.60.10.50.2-0.10.2-0.20.20.10.20.30.8
Pavlov. Cond. change in total contacts1.41.94.1-0.9-0.7-1.41.5-1.41.4-1.4-1.4-1.5-1.22.0
Pavlov. Cond. index score0.50.72.6-0.6-0.2-0.70.8-0.80.7-0.8-0.8-0.8-0.61.6
Pavlov. Cond. latency score0.81.03.1-0.7-0.4-1.01.1-1.01.0-1.0-1.0-1.0-0.81.8
Pavlov. Cond. lever contacts1.72.33.7-1.6-0.9-1.51.6-1.51.5-1.5-1.6-1.5-1.31.9
Pavlov. Cond. magazine entry number0.20.32.1-0.10.20.3-0.40.4-0.30.40.40.40.2-1.4
Pavlov. Cond. intertrial magazine entries0.40.50.7-0.8-0.6-0.80.7-0.70.7-0.7-0.6-0.8-0.8-0.2
Pavlov. Cond. lever-magazine prob. diff.0.50.72.8-0.5-0.2-0.70.8-0.70.7-0.7-0.8-0.7-0.51.7
Pavlov. Cond. response bias0.71.03.0-0.9-0.6-0.91.0-0.90.9-0.9-0.9-0.9-0.71.7
Time in closed arm before self-admin2.12.33.21.81.81.4-1.41.6-1.51.51.61.51.7-0.6
Time in closed arm after self-admin0.10.10.60.70.60.3-0.20.1-0.20.10.10.30.2-0.1
Time in open arm before self-admin0.30.32.2-0.6-1.50.1-0.2-0.1-0.10.1-0.00.1-0.2-0.9
Time in open arm after self-admin0.40.42.0-1.4-0.8-0.60.5-0.40.5-0.4-0.4-0.7-0.50.1
Bone: periosteal estimation1.73.66.5-2.6-1.5-2.01.9-1.81.9-1.8-1.8-2.1-1.71.6
Bone: periosteal perimeter0.91.54.7-2.2-0.6-1.31.2-1.11.2-1.1-1.1-1.4-1.00.8
Bone: post-yield work1.82.46.2-2.5-1.1-1.51.5-1.51.6-1.5-1.5-1.5-1.31.2
Progressive ratio test 1 active lever presses0.10.10.10.1-0.00.4-0.30.1-0.2-0.10.3-0.10.3-0.4
Progressive ratio test 1 breakpoint0.10.10.20.1-0.10.4-0.40.2-0.30.10.4-0.00.4-0.5
Progressive ratio test 1 inactive lever presses0.20.21.9-0.30.40.3-0.10.1-0.1-0.10.1-0.10.0-1.4
Progressive ratio test 2 active lever presses0.20.21.3-0.41.10.1-0.40.1-0.20.10.2-0.20.4-0.8
Progressive ratio test 2 breakpoint0.20.31.4-0.11.20.3-0.50.3-0.40.20.3-0.10.5-0.8
Progressive ratio test 2 inactive lever presses0.10.20.3-0.30.3-0.30.2-0.30.3-0.5-0.4-0.5-0.4-0.6
Incentive Sensitization - Responses0.10.11.0-0.51.00.1-0.2-0.0-0.0-0.0-0.1-0.00.1-0.4
Incentive Sensitization - Breakpoint0.20.21.4-0.51.20.1-0.20.0-0.10.00.0-0.00.2-0.4
Sum of active levers in priming session hrs 5-61.91.96.40.72.51.0-1.31.2-1.11.21.21.11.3-1.6
Progressive ratio0.40.51.0-0.41.0-0.50.7-0.90.8-0.8-0.9-0.4-0.7-0.4
Food seeking constrained by brief footshock6.17.514.8-3.9-2.7-2.62.8-2.82.8-2.9-2.8-2.5-2.61.1
Seeking ratio, punishment vs. effort1.21.45.0-1.8-2.2-1.00.9-0.80.9-0.9-0.8-1.0-0.81.0
Retroperitoneal fat weight0.10.30.50.60.50.6-0.60.7-0.60.70.60.60.6-0.2
Reaction time number correct0.10.10.4-0.30.60.2-0.30.4-0.30.50.30.30.4-0.4
Reaction time mean minus median2.63.45.7-0.7-0.8-1.81.9-2.12.0-2.1-2.1-1.8-1.92.4
Reaction time mean minus median AUC3.74.76.4-1.4-1.0-2.22.3-2.52.3-2.4-2.5-2.1-2.32.4
Reaction time num false alarms0.30.41.4-0.3-0.3-0.70.7-0.50.6-0.6-0.5-0.6-0.61.2
Reaction time num false alarms AUC0.60.91.6-1.0-0.8-0.91.0-0.90.9-0.9-0.8-0.8-0.91.3
Reaction time trials correct on left0.10.10.4-0.30.60.2-0.30.4-0.30.50.30.30.4-0.4
Reaction time trials on left0.10.20.6-0.20.80.3-0.40.5-0.40.50.40.40.5-0.4
Reaction time mean0.30.42.11.10.70.4-0.3-0.0-0.10.00.00.40.21.5
Reaction time mean AUC0.30.52.31.20.70.5-0.30.1-0.20.10.10.50.31.5
Median of all reaction times1.11.52.61.61.31.4-1.21.0-1.11.01.01.31.30.7
Reaction time omissions0.40.62.90.21.70.5-0.50.8-0.50.80.80.50.70.3
Reaction time false alarm rate0.20.21.1-0.1-0.5-0.30.4-0.40.4-0.5-0.3-0.3-0.41.0
Reaction time premature initiation rate1.62.14.82.22.11.3-1.21.3-1.31.21.31.31.1-1.1
Reaction time premature initiations1.42.04.91.82.21.3-1.21.3-1.21.31.21.31.1-1.3
Std. dev. reaction times0.60.83.30.4-0.0-0.60.7-1.10.8-1.0-1.0-0.5-0.91.8
Reaction time trials completed0.10.20.6-0.20.80.3-0.40.5-0.40.50.40.40.5-0.4
Reaction time trials AUC0.10.20.5-0.10.70.3-0.40.5-0.40.60.40.40.5-0.5
Run reversals in cocaine runway, females0.20.20.60.8-0.6-0.30.4-0.40.4-0.5-0.5-0.2-0.50.1
Run reversals in cocaine runway, males0.20.20.50.70.10.7-0.30.2-0.40.10.20.70.0-0.6
Latency to leave start box in cocaine runway0.40.41.1-0.7-1.1-0.50.4-0.50.5-0.5-0.5-0.2-0.60.9
Latency to leave start box in cocaine runway, F0.60.61.50.20.71.0-1.00.7-0.80.70.71.20.7-0.2
Latency to leave start box in cocaine runway, M1.00.93.8-1.0-1.9-0.80.9-0.80.7-0.8-0.8-0.8-0.90.4
Std. dev. time between licks in bursts0.50.60.90.50.80.8-0.80.8-0.80.80.80.70.90.1
Total sessions with >9 infusions0.20.31.0-0.70.8-0.20.2-0.50.3-0.4-0.4-0.2-0.3-1.0
Short access day 1 total inactive lever presses0.30.41.7-0.5-0.7-0.30.4-0.60.3-0.6-0.4-0.6-0.5-1.3
Short access day 10 total inactive lever presses0.70.81.4-0.5-0.5-1.01.1-0.90.9-0.8-1.0-1.0-1.2-0.4
Short access day 1 total infusions0.60.61.9-1.4-0.5-0.60.5-0.90.6-0.8-0.7-0.6-0.7-1.0
Short access day 10 total infusions0.40.41.1-0.10.50.8-0.90.4-0.70.50.60.50.7-1.1
Short access total infusions0.10.10.8-0.60.20.0-0.2-0.2-0.0-0.1-0.1-0.20.1-0.9
Short access day 1 locomotion0.80.91.41.01.00.8-0.81.0-1.01.11.00.41.0-1.2
Short access day 10 total locomotion0.30.41.51.21.20.6-0.30.4-0.40.50.40.20.4-0.1
Short access total locomotion0.70.71.11.01.01.0-0.80.7-0.90.90.70.70.8-0.9
One hour access (0.3 mA shock)0.10.21.0-0.51.0-0.2-0.1-0.0-0.10.10.1-0.40.2-0.6
Compulsive drug intake0.20.20.40.2-0.20.5-0.30.6-0.60.60.50.50.6-0.3
One hour access (shock baseline)0.20.21.3-0.41.0-0.2-0.1-0.1-0.00.0-0.0-0.3-0.1-1.1
Social response proportion1.21.32.71.60.81.1-1.21.1-1.11.01.01.10.9-1.2
Social responses0.50.71.1-0.9-0.6-0.80.7-0.90.9-0.9-1.0-0.8-1.1-0.3
Social time0.10.10.9-0.71.00.0-0.0-0.00.10.0-0.00.00.2-0.1
Soleus weight0.31.01.9-1.01.40.9-0.80.9-0.90.90.91.01.2-0.9
Bone: stiffness4.16.58.5-2.9-2.8-2.62.5-2.52.5-2.5-2.5-2.4-2.42.3
Tibialis anterior weight5.318.231.7-5.6-4.3-4.14.2-4.24.3-4.2-4.2-4.2-4.03.3
Time to tail flick, vehicle, before self-admin1.41.53.81.11.91.1-1.01.3-1.11.21.31.11.1-0.7
Time to tail flick, vehicle, after self-admin1.01.11.6-1.1-0.0-1.21.3-1.21.2-1.0-1.2-0.8-1.10.5
Time to tail flick, test, before self-admin0.60.61.2-0.4-0.3-1.10.9-0.90.8-0.8-0.8-0.9-0.70.5
Time to tail flick, test, after self-admin0.20.21.60.1-0.10.0-0.00.0-0.00.10.00.30.41.3
Delta time to tail flick, vehicle, before/after SA1.61.62.3-1.3-0.9-1.41.3-1.41.4-1.3-1.5-1.1-1.20.8
Delta time to tail flick, test, before/after SA0.90.81.20.70.81.0-1.01.0-0.91.00.91.01.10.0
Tibia length0.20.62.5-1.6-0.1-0.70.7-0.70.7-0.7-0.7-0.7-0.60.0
Ambulatory time before self-admin0.70.83.2-1.2-1.8-0.80.7-0.40.5-0.4-0.5-0.9-0.7-0.8
Ambulatory time after self-admin2.12.33.4-1.3-1.5-1.91.7-1.71.6-1.7-1.6-1.2-1.70.2
Bone: tissue strength0.10.10.7-0.2-0.50.0-0.0-0.0-0.0-0.00.00.10.10.8
Total heroin consumption0.40.51.00.30.90.6-0.50.7-0.70.70.70.70.6-1.0
Bone: trabecular number1.11.72.7-1.2-1.6-1.31.3-1.31.2-1.3-1.3-1.0-1.31.2
Bone: trabecular spacing0.20.31.0-0.1-0.4-0.50.5-0.40.5-0.4-0.5-0.6-0.41.0
Bone: trabecular thickness0.50.60.80.80.20.8-0.80.9-0.90.90.90.80.9-0.4
Bone: trabecular tissue density2.73.85.4-1.6-2.3-1.92.0-1.92.0-1.9-2.0-2.1-2.11.1
Water consumed over 24 hours1.31.62.7-1.6-1.5-1.31.3-1.21.2-1.2-1.2-1.1-1.21.0
Number of responses in last shaping day0.40.42.1-1.30.50.3-0.20.2-0.20.10.10.30.1-1.4