Hub : Genes

RGD1311946

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression RGD1311946 0.47 0.18 0.0e+00 0.33 0.29 0.28 0.29 1.5e-18 1.1e-15 1.9e-15 9.0e-16
2 NAcc gene expression RGD1311946 0.03 0.02 4.6e-03 0.01 0.01 0.01 0.01 2.7e-02 1.3e-02 2.2e-02 3.3e-02
3 LHb gene expression RGD1311946 0.3 0.16 7.1e-05 0.2 0.02 0.16 -0.01 2.0e-05 1.1e-01 1.2e-04 9.4e-01
4 Brain gene expression RGD1311946 0.21 0.11 3.3e-16 0.16 0.11 0.16 0.06 3.9e-15 1.7e-10 6.7e-15 3.0e-06
5 OFC gene expression RGD1311946 0.17 0.12 7.1e-03 0.09 0.02 0.06 -0.01 4.8e-03 1.1e-01 1.3e-02 6.7e-01
6 PL gene expression RGD1311946 0.16 0.09 1.3e-13 0.12 0.13 0.13 0.13 1.2e-13 3.1e-14 6.6e-14 1.0e-13
7 Adipose gene expression RGD1311946 0.59 0.13 0.0e+00 0.45 0.47 0.47 0.47 4.9e-55 1.2e-57 1.1e-57 1.2e-57
8 Liver gene expression RGD1311946 0.14 0.07 3.3e-13 0.1 0.1 0.1 0.1 7.3e-11 2.0e-11 2.9e-11 3.9e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.52.43.9-1.41.1-1.4-1.5-1.61.5-1.92.0
Area under the delay curve0.90.91.3-0.90.8-1.1-1.0-0.90.9-1.01.1
BMI with tail0.10.41.4-0.3-0.4-0.3-0.3-0.40.3-1.21.2
BMI without tail0.10.10.5-0.1-0.4-0.1-0.1-0.10.1-0.70.7
Body weight1.14.88.52.2-2.92.32.32.3-2.31.3-1.3
Weight adjusted by age0.81.01.31.1-1.21.01.01.0-1.00.8-0.7
Bone surface0.30.61.8-0.40.1-0.4-0.5-0.80.7-1.11.3
Bone volume0.91.52.7-1.00.8-1.0-1.1-1.21.2-1.51.6
Breakpoint value in progressive ratio session0.80.81.41.1-1.20.91.00.9-0.90.7-0.5
Number of licking bursts0.10.10.2-0.10.2-0.4-0.3-0.30.3-0.20.3
Context. condit. distance diff. score0.91.01.4-1.01.1-1.2-1.2-0.91.0-0.80.9
Locomotion velocity, session 10.00.00.10.10.1-0.0-0.1-0.30.1-0.00.1
Locomotion distance, session 10.60.81.4-0.60.6-0.8-0.8-1.00.9-1.01.2
Locomotion velocity, session 21.31.62.31.3-1.51.31.31.3-1.30.9-0.9
Locomotion distance, session 20.00.00.10.2-0.20.10.2-0.30.1-0.20.4
Locomotion velocity, session 31.21.42.0-1.10.9-1.1-1.1-1.21.2-1.41.4
Locomotion distance, session 30.10.10.1-0.20.2-0.3-0.3-0.20.3-0.30.3
Stereotopy head waving bouts, day 31.72.02.6-1.61.2-1.5-1.4-1.21.4-1.51.5
Stereotopy head waving duration, day 31.82.22.8-1.71.5-1.6-1.5-1.41.4-1.31.4
Locomotion velocity, session 70.80.91.4-0.90.7-1.0-1.0-0.60.8-1.21.1
Locomotion distance, session 70.00.00.10.1-0.30.20.10.3-0.1-0.10.1
Stereotopy head waving bouts, day 72.12.32.9-1.71.4-1.6-1.4-1.51.5-1.61.5
Stereotopy head waving duration, day 70.60.71.2-0.90.4-0.8-0.6-0.70.7-1.11.1
Locomotion velocity, session 80.70.81.31.0-1.11.00.91.0-0.90.7-0.6
Locomotion distance, session 80.50.81.0-0.60.9-0.9-0.9-1.00.9-0.70.9
Degree of sensitization distance0.00.00.1-0.1-0.1-0.1-0.10.10.1-0.30.3
Degree of sensitization stereotypy0.30.40.6-0.60.4-0.6-0.4-0.70.6-0.70.8
Conditioned locomotion4.65.36.02.5-2.32.42.42.2-2.32.3-2.2
Cocaine response after cond. corrected0.20.20.3-0.50.4-0.5-0.4-0.40.4-0.40.4
Cocaine response after cond. not corrected0.60.70.8-0.80.8-0.8-0.7-0.90.8-0.80.8
Cocaine response before conditioning0.10.10.3-0.20.2-0.2-0.2-0.50.3-0.40.4
Saline control response1.11.52.41.2-1.61.31.21.3-1.30.9-0.8
Bone: connectivity density0.50.82.2-0.50.2-0.5-0.6-0.90.8-1.31.5
Bone: cortical apparent density0.60.81.00.9-1.00.90.91.0-1.00.8-0.8
Bone: cortical area0.91.31.61.2-1.11.21.20.9-1.11.2-1.1
Bone: cortical porosity0.10.10.1-0.20.3-0.2-0.3-0.40.3-0.20.3
Bone: cortical porosity0.10.10.20.4-0.40.40.30.3-0.30.3-0.2
Bone: cortical thickness5.99.811.13.3-3.23.33.32.8-3.13.1-2.9
Bone: cortical thickness2.42.83.41.8-1.81.81.81.5-1.71.6-1.5
Bone: cortical tissue density0.81.11.31.0-1.11.01.11.1-1.10.9-0.9
Condit. Reinf. active minus inactive responses0.30.30.6-0.40.4-0.5-0.4-0.80.6-0.60.7
Condit. Reinf. active-inactive response ratio0.40.40.6-0.50.6-0.6-0.6-0.80.7-0.70.7
Condit. Reinf. active responses0.10.10.3-0.20.3-0.2-0.2-0.60.3-0.30.3
Condit. Reinf. inactive responses0.00.00.00.1-0.00.2-0.0-0.0-0.10.1-0.2
Incentive salience index mean0.10.20.5-0.20.3-0.3-0.3-0.70.4-0.40.5
Condit. Reinf. lever presses0.00.10.10.4-0.10.30.2-0.1-0.10.3-0.2
Condit. Reinf. active minus inactive responses2.63.24.4-1.71.7-1.6-1.6-2.11.8-1.81.8
Condit. Reinf. active-inactive response ratio3.13.34.9-1.82.0-1.7-1.7-2.21.9-1.51.6
Condit. Reinf. active responses1.72.43.1-1.51.3-1.4-1.4-1.71.6-1.71.7
Condit. Reinf. inactive responses0.10.10.4-0.3-0.1-0.2-0.2-0.00.2-0.60.6
Condit. Reinf. lever presses0.10.20.5-0.20.1-0.2-0.2-0.50.4-0.50.7
Condit. Reinf. lever reinforcers received1.42.02.7-1.41.1-1.2-1.3-1.51.4-1.61.6
Conditioned reinforcement - actives0.10.10.20.2-0.00.20.20.3-0.20.3-0.5
Conditioned reinforcement - inactives2.93.24.8-2.02.2-1.9-1.7-1.91.8-1.41.2
Conditioned locomotion1.41.74.0-1.42.0-1.3-1.3-1.41.3-0.40.4
Patch foraging indifference point 0 sec0.20.40.7-0.80.6-0.8-0.6-0.30.5-0.70.4
Patch foraging indifference point AUC1.61.92.61.6-1.41.41.31.1-1.31.5-1.2
Delay disc. indifference point, 0s delay1.61.82.5-1.21.1-1.3-1.3-1.41.3-1.61.5
Delay disc. indifference point, 16s delay1.31.31.9-1.21.3-1.4-1.2-1.11.1-0.90.9
Delay disc. indifference point, 2s delay0.91.01.3-1.11.0-1.1-1.0-0.91.0-0.91.0
Delay disc. indifference point, 24s delay0.50.40.60.7-0.60.50.70.8-0.70.7-0.7
Delay disc. indifference point, 4s delay0.20.30.4-0.40.4-0.5-0.6-0.50.5-0.50.6
Delay disc. indifference point, 8s delay0.10.10.3-0.30.2-0.5-0.3-0.20.3-0.50.5
Indifference point function ln k1.82.53.8-1.92.0-1.8-1.6-1.51.6-1.21.0
Indifference point function log k1.82.53.8-1.92.0-1.8-1.6-1.51.6-1.21.0
Patch foraging total patch changes 0 sec0.00.00.2-0.2-0.0-0.20.00.4-0.1-0.1-0.2
Patch foraging total patch changes 12 sec1.31.72.61.4-1.61.21.31.4-1.41.0-1.0
Patch foraging total patch changes 18 sec0.00.10.10.3-0.40.10.10.3-0.30.1-0.1
Patch foraging total patch changes 24 sec1.31.62.31.3-1.41.01.21.5-1.31.2-1.1
Patch foraging total patch changes 6 sec0.00.10.20.1-0.4-0.00.10.2-0.2-0.30.2
Patch foraging time to switch 0 sec0.40.61.5-0.40.2-0.7-0.7-0.60.6-1.21.2
Patch foraging water rate 0 sec0.20.31.2-0.00.50.10.20.3-0.21.0-1.1
Patch foraging water rate 12 sec0.20.31.0-0.21.0-0.1-0.2-0.30.20.9-0.8
Patch foraging water rate 18 sec0.20.20.7-0.60.8-0.4-0.4-0.50.50.10.0
Patch foraging water rate 24 sec0.30.41.10.20.10.40.40.5-0.41.0-1.1
Patch foraging water rate 6 sec0.40.51.40.5-0.20.50.50.7-0.61.2-1.2
Seeking ratio, delayed vs. immediate footshock0.40.50.7-0.70.5-0.7-0.7-0.60.6-0.80.8
Distance traveled before self-admin0.00.00.00.0-0.0-0.1-0.2-0.20.10.00.2
Distance traveled after self-admin0.00.10.1-0.30.2-0.0-0.3-0.30.2-0.30.2
Extensor digitorum longus weight4.417.223.44.3-4.84.34.34.3-4.23.4-3.3
Bone: elastic displacement1.82.03.01.3-1.01.41.31.3-1.41.7-1.7
Bone: elastic work3.14.04.62.1-2.02.22.01.9-2.02.0-1.9
Bone: endosteal estimation2.35.15.8-2.32.3-2.3-2.4-2.12.2-2.22.1
Bone: endosteal perimeter5.110.511.4-3.33.3-3.3-3.4-3.13.3-3.13.1
Epididymis fat weight1.94.46.3-2.32.5-2.3-2.1-2.32.1-1.51.5
Delta time in closed arm before/after self-admin1.41.41.61.1-1.21.31.21.1-1.21.1-1.1
Delta time in open arm before/after self-admin0.40.40.5-0.50.6-0.7-0.6-0.70.6-0.50.5
Diff in mean of infusions in LGA sessions0.50.50.91.0-0.70.70.70.6-0.70.8-0.6
Delay discount exponential model param0.50.60.90.7-0.60.90.80.6-0.70.8-0.9
Extinction: sum of active levers before priming0.70.71.31.1-1.20.90.80.7-0.80.5-0.2
Active lever presses in extinction session 62.82.72.91.7-1.61.71.71.5-1.61.7-1.6
Bone: final force0.30.51.10.9-1.00.80.80.7-0.70.5-0.3
Bone: final moment0.30.51.00.9-1.00.80.70.6-0.70.5-0.3
Food consumed during 24 hour testing period0.00.00.10.00.2-0.0-0.0-0.20.10.2-0.2
Glucose3.65.46.0-2.32.3-2.3-2.4-2.42.3-2.22.2
Heart weight1.21.72.2-1.41.5-1.2-1.5-1.41.3-1.21.1
Delay discount hyperbolic model param0.50.60.80.7-0.60.90.80.7-0.70.8-0.9
Intermittent access intake day 1-15 change0.20.20.6-0.40.8-0.4-0.6-0.60.50.10.1
Intermittent access intake escalation0.60.61.1-0.61.0-0.7-0.9-0.90.8-0.30.5
Intermittent access intake escalation 20.10.10.2-0.20.5-0.2-0.5-0.40.3-0.00.0
Intermitt. access day 1 inactive lever presses1.11.11.9-1.41.2-1.1-0.9-1.01.0-1.00.8
Intermitt. access day 15 inactive lever presses2.12.32.9-1.71.6-1.6-1.5-1.51.5-1.41.2
Intermitt. access escalation Index0.70.61.2-0.71.1-0.7-0.9-0.90.8-0.20.4
Intermittent access day 1 total infusions7.99.110.7-3.32.9-3.2-2.9-3.02.9-3.22.8
Intermittent access day 15 total infusions6.97.89.4-3.03.1-3.0-2.8-2.92.8-2.52.2
Intermittent access terminal intake (last 3 days)6.47.08.1-2.82.8-2.9-2.7-2.72.6-2.52.2
Intermittent access total infusions5.25.76.9-2.52.4-2.6-2.4-2.42.3-2.32.1
Intermittent access day 1 locomotion4.54.75.8-2.41.9-2.4-2.0-2.12.0-2.42.1
Intermittent access day 15 total locomotion4.04.35.4-2.22.3-2.2-2.1-2.22.1-1.71.7
Intermittent access total locomotion8.29.310.5-3.23.1-3.2-3.1-3.23.0-2.82.7
Intermittent access standard deviation0.30.30.5-0.50.7-0.7-0.7-0.70.6-0.40.3
Left kidney weight0.10.30.7-0.40.9-0.3-0.5-0.70.5-0.0-0.0
Right kidney weight0.00.10.40.10.30.20.2-0.0-0.10.6-0.7
Cocaine induced anxiety0.00.00.0-0.10.10.1-0.0-0.20.1-0.10.0
Post-drug Anxiety1.61.72.51.3-1.41.61.41.3-1.31.2-1.2
Baseline Anxiety2.22.42.81.6-1.71.61.51.6-1.51.4-1.3
Tail length1.75.36.62.1-2.42.32.42.6-2.42.0-2.2
Length with tail2.910.612.83.3-3.63.43.33.5-3.42.8-2.8
Length without tail2.04.45.72.2-2.42.32.12.2-2.11.7-1.7
Times rat made contact with spout0.10.10.2-0.0-0.0-0.1-0.1-0.30.2-0.40.5
Lifetime Intake4.34.95.8-2.42.2-2.4-2.2-2.22.1-2.31.9
Liver weight, left0.10.10.2-0.30.4-0.3-0.3-0.40.3-0.10.2
Liver weight, right0.10.20.30.4-0.10.50.50.0-0.30.6-0.5
Locomotor activity0.00.10.3-0.20.50.0-0.2-0.40.30.1-0.1
Locomotor testing distance0.10.10.4-0.30.6-0.2-0.3-0.30.30.0-0.1
Locomotor testing rearing1.11.72.3-1.31.5-1.2-1.3-1.51.4-1.01.1
Locomotion in novel chamber4.75.87.6-2.62.8-2.6-2.5-2.52.4-2.01.9
Locomotion in novel chamber post-restriction1.51.82.8-1.51.7-1.3-1.3-1.41.4-0.90.9
Fecal boli incidents, locomotor time 10.10.10.1-0.30.3-0.3-0.1-0.40.3-0.20.2
Change in fecal boli incidents, locomotor task0.00.00.10.1-0.30.00.10.2-0.2-0.10.1
Time >=10cm from walls, locomotor time 14.64.75.8-2.22.0-2.2-2.2-2.12.1-2.42.1
Bouts of movement, locomotor time 11.81.92.51.5-1.41.41.21.6-1.41.4-1.3
Total resting periods, locomotor time 11.11.21.71.2-1.01.10.91.3-1.11.2-1.0
Rest time, locomotor task time 10.10.10.2-0.10.4-0.1-0.2-0.00.10.3-0.4
Distance moved, locomotor task time 10.70.81.1-0.90.6-0.9-0.8-1.00.8-1.01.0
Vertical activity count, locomotor time 11.61.72.1-1.51.3-1.4-1.3-1.41.2-1.21.1
Time >=10cm from walls, locomotor time 20.00.00.10.10.10.2-0.00.2-0.10.1-0.2
Bouts of movement, locomotor time 20.50.60.80.8-0.80.70.90.8-0.70.5-0.6
Total resting periods, locomotor time 20.10.10.20.5-0.40.40.50.4-0.40.2-0.2
Rest time, locomotor task time 22.83.34.0-1.81.9-1.9-1.9-2.01.8-1.71.6
Distance moved, locomotor task time 21.31.51.71.2-1.31.21.21.3-1.31.3-1.2
Vertical activity count, locomotor time 22.42.63.21.5-1.41.61.61.7-1.61.8-1.8
Light reinforcement 10.10.20.3-0.30.6-0.6-0.4-0.40.30.2-0.0
Light reinforcement 20.50.71.5-0.71.2-0.9-0.9-1.00.9-0.20.4
Bone: marrow area2.35.15.8-2.32.3-2.3-2.4-2.12.2-2.22.1
Bone: maximum diameter0.00.00.1-0.10.2-0.1-0.1-0.20.10.1-0.0
Bone: maximum force0.20.31.0-0.2-0.1-0.3-0.3-0.50.4-0.81.0
Bone: maximum moment0.10.20.8-0.2-0.1-0.2-0.3-0.40.3-0.70.9
Mean time between licks in bursts0.71.01.40.9-1.21.11.01.1-1.00.7-0.8
Mean num. licks in bursts0.00.00.1-0.20.10.1-0.1-0.20.2-0.30.2
Cd content in liver0.30.30.8-0.60.9-0.6-0.7-0.60.6-0.30.2
Co content in liver0.40.40.80.7-0.30.60.60.5-0.60.9-0.9
Cu content in liver0.30.30.50.5-0.60.50.50.7-0.60.4-0.5
Fe content in liver0.00.00.10.2-0.10.20.1-0.1-0.10.1-0.1
K content in liver0.20.20.5-0.2-0.0-0.3-0.2-0.40.3-0.60.7
Mg content in liver2.82.83.8-1.61.4-1.7-1.6-1.71.7-1.81.9
Mn content in liver0.40.40.80.7-0.90.80.80.6-0.70.4-0.4
Na content in liver0.40.40.70.7-0.50.50.60.6-0.60.9-0.7
Rb content in liver4.15.15.6-2.32.2-2.2-2.2-2.32.3-2.42.2
Se content in liver0.91.11.7-1.10.9-1.3-1.1-0.91.0-1.11.1
Sr content in liver3.22.93.31.8-1.81.71.81.6-1.81.6-1.6
Zn content in liver0.60.60.90.8-0.90.90.80.8-0.80.6-0.6
Bone: minimum diameter2.95.45.8-2.32.3-2.3-2.3-2.42.4-2.32.4
Time in familiar zone, hab. session 10.80.80.9-0.80.9-0.8-0.9-0.90.9-0.90.8
Time in novel zone, hab. session 10.10.10.20.3-0.40.30.40.5-0.40.4-0.4
Total zone transitions, hab. session 10.00.00.10.3-0.30.20.3-0.1-0.10.00.1
Total locomotion distance, hab. session 10.60.81.2-0.91.0-0.9-0.9-1.11.0-0.70.8
Locomotion velocity, hab. session 10.20.30.5-0.40.6-0.5-0.4-0.70.6-0.30.4
Time in familiar zone, hab. session 21.41.41.71.3-1.21.31.21.2-1.21.2-1.2
Time in novel zone, hab. session 21.31.31.6-1.20.9-1.2-1.1-1.01.1-1.31.2
Total zone transitions, hab. session 21.01.32.8-0.90.6-1.0-1.0-1.11.1-1.51.7
Total locomotion distance, hab. session 21.21.62.2-1.21.1-1.2-1.2-1.41.3-1.41.5
Locomotion velocity, hab. session 21.52.12.5-1.31.3-1.4-1.4-1.61.5-1.51.6
Novel to familiar place preference ratio0.20.20.4-0.40.2-0.5-0.4-0.20.3-0.60.5
Novelty place preference0.40.40.7-0.70.4-0.7-0.7-0.40.5-0.80.7
Time in novel zone, NPP test0.40.40.7-0.70.4-0.7-0.7-0.40.6-0.80.7
Total zone transitions, NPP test0.10.10.40.1-0.1-0.1-0.2-0.30.2-0.40.6
Total locomotion distance, NPP test0.40.60.9-0.60.7-0.7-0.8-0.90.8-0.70.9
Locomotion velocity, NPP test0.30.40.6-0.50.6-0.6-0.6-0.80.7-0.50.7
Intraocular pressure0.20.30.70.5-0.10.50.50.2-0.40.8-0.8
Delta distance traveled before/after self-admin0.00.00.0-0.00.00.20.1-0.10.0-0.1-0.0
Delta ambulatory time before/after self-admin0.10.10.20.1-0.30.50.40.3-0.30.1-0.3
Parametrial fat weight2.44.85.6-2.02.3-2.3-2.3-2.42.2-1.92.0
Pavlov. Cond. lever latency0.00.00.0-0.10.10.0-0.00.00.0-0.1-0.1
Pavlov. Cond. magazine entry latency1.11.41.8-1.21.0-1.3-1.3-1.01.2-1.31.3
Pavlov. Cond. change in total contacts1.11.11.3-1.11.1-1.1-1.1-1.11.1-0.91.0
Pavlov. Cond. index score0.10.10.2-0.20.4-0.4-0.4-0.40.4-0.10.3
Pavlov. Cond. latency score0.20.20.3-0.30.4-0.5-0.5-0.50.5-0.30.5
Pavlov. Cond. lever contacts0.00.00.1-0.00.2-0.2-0.2-0.30.20.00.3
Pavlov. Cond. magazine entry number0.00.00.10.1-0.20.20.20.1-0.2-0.0-0.1
Pavlov. Cond. intertrial magazine entries0.20.20.40.4-0.20.40.40.3-0.40.6-0.7
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.10.3-0.2-0.3-0.40.3-0.10.3
Pavlov. Cond. response bias0.10.10.1-0.20.3-0.3-0.3-0.30.3-0.10.3
Pavlov. Cond. lever latency0.00.10.30.0-0.2-0.00.10.5-0.20.1-0.2
Pavlov. Cond. magazine entry latency0.10.10.40.3-0.60.30.30.0-0.1-0.20.4
Pavlov. Cond. change in total contacts0.30.40.7-0.50.4-0.5-0.5-0.70.6-0.70.8
Pavlov. Cond. index score0.00.00.20.0-0.10.0-0.0-0.30.1-0.20.4
Pavlov. Cond. latency score0.00.00.20.0-0.1-0.0-0.1-0.30.2-0.20.4
Pavlov. Cond. lever contacts0.10.10.10.4-0.10.40.3-0.2-0.10.3-0.2
Pavlov. Cond. magazine entry number0.10.20.6-0.40.7-0.4-0.4-0.10.20.3-0.4
Pavlov. Cond. intertrial magazine entries0.20.30.5-0.70.7-0.7-0.7-0.10.4-0.30.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.1-0.30.10.1-0.20.0-0.20.4
Pavlov. Cond. response bias0.00.00.10.3-0.20.30.2-0.30.0-0.10.2
Time in closed arm before self-admin0.40.40.6-0.60.6-0.7-0.7-0.60.6-0.70.6
Time in closed arm after self-admin0.20.20.30.5-0.40.40.50.5-0.50.4-0.5
Time in open arm before self-admin0.50.50.80.7-0.70.90.80.7-0.70.8-0.6
Time in open arm after self-admin0.10.10.10.3-0.20.30.20.2-0.20.3-0.3
Bone: periosteal estimation0.20.30.4-0.50.6-0.6-0.6-0.60.6-0.50.5
Bone: periosteal perimeter0.50.80.9-0.90.9-0.9-1.0-0.90.9-0.91.0
Bone: post-yield work7.910.713.4-3.12.8-3.2-3.2-3.23.2-3.63.7
Progressive ratio test 1 active lever presses0.60.60.9-0.90.9-0.9-0.7-0.70.7-0.80.4
Progressive ratio test 1 breakpoint0.30.40.6-0.80.8-0.7-0.5-0.50.6-0.60.2
Progressive ratio test 1 inactive lever presses0.40.50.8-0.90.7-0.7-0.5-0.70.6-0.80.5
Progressive ratio test 2 active lever presses1.81.92.6-1.61.6-1.5-1.4-1.31.3-1.31.0
Progressive ratio test 2 breakpoint1.31.42.3-1.41.5-1.3-1.2-1.11.2-1.00.6
Progressive ratio test 2 inactive lever presses6.37.38.9-3.03.0-2.9-2.7-2.72.6-2.52.1
Incentive Sensitization - Responses0.30.30.4-0.60.6-0.5-0.5-0.50.5-0.60.4
Incentive Sensitization - Breakpoint0.40.40.6-0.70.7-0.6-0.7-0.70.6-0.70.5
Sum of active levers in priming session hrs 5-63.13.03.61.6-1.41.91.81.7-1.71.9-1.9
Progressive ratio0.60.71.8-0.70.1-0.6-0.7-0.60.7-1.31.3
Food seeking constrained by brief footshock0.10.10.40.1-0.50.20.40.7-0.40.2-0.2
Seeking ratio, punishment vs. effort0.40.51.20.4-0.20.40.60.7-0.61.1-1.1
Retroperitoneal fat weight3.09.714.0-3.43.7-3.4-3.2-3.23.2-2.32.2
Reaction time number correct1.01.42.11.5-1.11.31.30.8-1.11.3-1.1
Reaction time mean minus median0.20.20.60.5-0.70.70.70.1-0.3-0.30.0
Reaction time mean minus median AUC0.60.81.61.1-1.01.31.10.4-0.80.4-0.6
Reaction time num false alarms0.81.11.31.0-0.91.01.11.0-1.01.0-1.1
Reaction time num false alarms AUC1.31.72.11.3-1.31.31.41.4-1.31.2-1.3
Reaction time trials correct on left1.01.42.11.5-1.11.31.30.8-1.11.3-1.1
Reaction time trials on left1.21.82.61.6-1.21.51.41.0-1.21.4-1.2
Reaction time mean0.30.51.0-0.70.5-0.5-0.7-0.70.6-1.00.7
Reaction time mean AUC0.50.71.2-0.80.7-0.6-0.8-0.80.8-1.10.8
Median of all reaction times0.71.01.4-1.00.9-0.9-1.1-0.90.9-1.21.0
Reaction time omissions1.01.32.21.4-1.31.51.30.8-1.10.7-0.8
Reaction time false alarm rate0.30.50.80.5-0.70.60.70.9-0.80.5-0.7
Reaction time premature initiation rate1.72.33.11.6-1.81.71.71.6-1.51.0-1.1
Reaction time premature initiations3.95.46.72.5-2.52.62.52.2-2.31.9-1.9
Std. dev. reaction times0.10.10.30.1-0.20.30.2-0.20.0-0.60.2
Reaction time trials completed1.21.82.61.6-1.21.51.41.0-1.21.4-1.2
Reaction time trials AUC0.91.32.01.4-1.01.21.20.8-1.01.2-1.1
Run reversals in cocaine runway, females0.20.20.6-0.30.0-0.3-0.3-0.30.4-0.80.8
Run reversals in cocaine runway, males1.01.01.31.0-0.81.11.10.6-0.91.1-1.1
Latency to leave start box in cocaine runway1.21.31.5-1.10.9-1.2-1.2-0.91.1-1.21.2
Latency to leave start box in cocaine runway, F0.70.71.0-0.90.7-0.8-0.9-0.80.8-0.91.0
Latency to leave start box in cocaine runway, M0.00.00.1-0.10.2-0.3-0.3-0.00.2-0.20.2
Std. dev. time between licks in bursts2.02.42.81.6-1.51.71.61.4-1.51.5-1.6
Total sessions with >9 infusions0.91.01.5-1.21.0-1.0-0.9-0.90.9-1.00.8
Short access day 1 total inactive lever presses2.02.23.3-1.81.6-1.6-1.3-1.51.4-1.41.1
Short access day 10 total inactive lever presses1.11.21.6-1.31.2-1.2-1.0-1.11.1-0.90.8
Short access day 1 total infusions3.33.54.7-2.21.8-2.0-1.9-1.81.8-2.01.6
Short access day 10 total infusions4.44.96.5-2.41.9-2.3-2.1-2.12.1-2.52.2
Short access total infusions2.12.33.3-1.71.3-1.7-1.4-1.41.4-1.81.4
Short access day 1 locomotion2.83.03.7-1.91.7-1.8-1.7-1.81.7-1.71.6
Short access day 10 total locomotion1.51.72.1-1.51.2-1.3-1.3-1.31.3-1.41.2
Short access total locomotion1.41.41.8-1.31.1-1.3-1.0-1.21.1-1.31.1
One hour access (0.3 mA shock)4.95.77.5-2.62.7-2.5-2.4-2.42.3-2.11.7
Compulsive drug intake4.84.85.72.1-2.42.32.42.3-2.21.9-1.9
One hour access (shock baseline)5.76.69.1-2.73.0-2.8-2.7-2.72.6-2.11.8
Social response proportion0.10.10.20.1-0.20.30.1-0.30.1-0.50.3
Social responses0.50.71.21.1-0.81.00.90.4-0.70.7-0.7
Social time0.20.30.60.8-0.70.60.60.4-0.50.4-0.4
Soleus weight0.61.73.9-1.52.0-1.5-1.5-1.21.3-0.40.3
Bone: stiffness0.40.71.6-0.70.3-0.8-0.7-0.70.7-1.11.3
Tibialis anterior weight9.432.137.25.8-6.15.95.95.6-5.75.2-5.0
Time to tail flick, vehicle, before self-admin1.01.01.7-0.90.6-1.2-1.0-0.90.9-1.11.3
Time to tail flick, vehicle, after self-admin0.50.61.20.8-1.10.80.80.7-0.80.4-0.3
Time to tail flick, test, before self-admin1.81.82.3-1.41.1-1.4-1.3-1.31.3-1.51.5
Time to tail flick, test, after self-admin0.10.10.20.4-0.30.20.30.3-0.30.4-0.2
Delta time to tail flick, vehicle, before/after SA0.90.91.31.0-1.01.20.90.9-0.90.7-0.8
Delta time to tail flick, test, before/after SA4.84.34.82.1-1.92.02.12.2-2.12.2-2.1
Tibia length0.82.32.71.6-1.31.61.61.4-1.51.6-1.6
Ambulatory time before self-admin0.10.10.3-0.10.3-0.4-0.5-0.50.4-0.20.5
Ambulatory time after self-admin1.82.02.3-1.41.3-1.3-1.5-1.51.4-1.41.4
Bone: tissue strength0.50.51.1-0.60.8-0.6-0.6-1.00.8-0.50.7
Total heroin consumption2.42.84.11.9-2.01.51.81.8-1.71.2-1.2
Bone: trabecular number1.21.83.1-1.20.9-1.2-1.3-1.41.3-1.61.8
Bone: trabecular spacing0.40.50.90.6-0.50.50.50.9-0.70.9-0.9
Bone: trabecular thickness2.53.03.6-1.81.6-1.6-1.7-1.71.7-1.91.8
Bone: trabecular tissue density0.60.92.2-1.01.5-1.1-1.1-0.80.9-0.20.1
Water consumed over 24 hours0.00.10.20.2-0.40.20.10.3-0.20.00.1
Number of responses in last shaping day0.10.10.2-0.20.4-0.4-0.2-0.30.3-0.30.1