Fgf17

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Fgf17	0.04	0.03	6.2e-05	0.03	0.04	0.03	0.03	1.3e-04	8.5e-05	1.4e-04	1.8e-04
2	pVTA	intron excision ratio	chr15_52123455_52123704	0.04	0.04	3.7e-03	0.01	0.01	0.01	0.01	4.7e-02	2.8e-02	9.0e-02	6.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2
Bone: apparent density	0.8	1.6	2.2	1.5	-1.0
Area under the delay curve	0.1	0.1	0.2	-0.2	0.4
BMI with tail	0.3	1.1	2.2	-1.5	0.2
BMI without tail	0.1	0.5	1.0	-0.3	-1.0
Body weight	0.6	2.5	3.1	-1.8	1.4
Weight adjusted by age	0.7	2.1	2.2	-1.4	1.5
Bone surface	0.4	0.7	1.4	1.2	-0.3
Bone volume	0.4	0.9	1.5	1.2	-0.4
Breakpoint value in progressive ratio session	0.0	0.1	0.1	-0.2	0.3
Number of licking bursts	0.0	0.0	0.0	-0.0	-0.2
Context. condit. distance diff. score	2.9	3.5	6.8	0.5	-2.6
Locomotion velocity, session 1	0.2	0.2	0.3	-0.4	0.5
Locomotion distance, session 1	0.4	0.5	0.7	0.5	0.9
Locomotion velocity, session 2	0.1	0.2	0.2	0.4	0.4
Locomotion distance, session 2	0.8	1.1	1.9	0.6	1.4
Locomotion velocity, session 3	0.5	0.5	1.0	-1.0	-0.3
Locomotion distance, session 3	0.3	0.3	0.7	-0.0	-0.8
Stereotopy head waving bouts, day 3	0.6	0.7	0.7	-0.9	0.8
Stereotopy head waving duration, day 3	2.2	2.7	2.7	-1.7	1.6
Locomotion velocity, session 7	7.1	7.8	13.1	1.6	-3.6
Locomotion distance, session 7	4.8	6.1	9.7	1.6	-3.1
Stereotopy head waving bouts, day 7	1.6	1.9	2.4	-1.2	1.5
Stereotopy head waving duration, day 7	2.0	2.5	2.6	-1.5	1.6
Locomotion velocity, session 8	0.2	0.3	0.5	-0.1	-0.7
Locomotion distance, session 8	0.6	0.9	0.9	1.0	-1.0
Degree of sensitization distance	4.6	5.0	6.4	1.9	-2.5
Degree of sensitization stereotypy	1.0	1.2	1.2	-1.1	1.1
Conditioned locomotion	0.2	0.3	0.6	0.0	-0.8
Cocaine response after cond. corrected	0.4	0.6	0.8	-0.9	-0.7
Cocaine response after cond. not corrected	0.2	0.3	0.4	-0.6	-0.4
Cocaine response before conditioning	0.4	0.5	0.5	0.7	0.7
Saline control response	0.2	0.3	0.3	0.6	0.5
Bone: connectivity density	1.9	3.1	3.7	1.9	-1.6
Bone: cortical apparent density	0.7	1.0	2.1	-0.1	-1.4
Bone: cortical area	0.1	0.1	0.2	0.2	0.4
Bone: cortical porosity	1.7	1.9	3.0	-0.9	1.7
Bone: cortical porosity	1.3	1.5	2.6	-0.5	1.6
Bone: cortical thickness	0.0	0.0	0.0	0.1	0.0
Bone: cortical thickness	0.3	0.4	0.7	-0.2	-0.8
Bone: cortical tissue density	0.7	1.2	2.4	-0.1	-1.5
Condit. Reinf. active minus inactive responses	0.6	0.7	1.1	-0.5	1.1
Condit. Reinf. active-inactive response ratio	1.5	1.7	2.4	-1.5	1.0
Condit. Reinf. active responses	0.3	0.4	0.8	0.3	0.9
Condit. Reinf. inactive responses	1.7	2.2	4.4	2.1	-0.1
Incentive salience index mean	1.3	1.6	2.9	-0.6	1.7
Condit. Reinf. lever presses	0.9	1.3	2.6	-0.2	1.6
Condit. Reinf. active minus inactive responses	0.2	0.4	0.4	0.7	-0.5
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.1	-0.3	-0.1
Condit. Reinf. active responses	0.7	1.0	1.3	1.1	-0.8
Condit. Reinf. inactive responses	1.2	1.8	2.9	1.7	-0.9
Condit. Reinf. lever presses	0.2	0.4	0.5	0.7	0.5
Condit. Reinf. lever reinforcers received	0.5	0.7	1.0	1.0	-0.6
Conditioned reinforcement - actives	0.5	1.8	2.2	1.2	-1.5
Conditioned reinforcement - inactives	1.2	3.4	5.7	2.4	-1.1
Conditioned locomotion	0.2	0.2	0.3	0.4	-0.6
Patch foraging indifference point 0 sec	0.9	2.6	5.2	2.3	0.3
Patch foraging indifference point AUC	0.1	0.3	0.5	-0.7	-0.2
Delay disc. indifference point, 0s delay	0.4	0.4	0.7	0.9	0.3
Delay disc. indifference point, 16s delay	0.1	0.2	0.3	0.5	-0.4
Delay disc. indifference point, 2s delay	1.7	1.9	2.6	-1.1	1.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.5	-0.1
Delay disc. indifference point, 4s delay	1.4	1.5	1.9	-1.4	1.0
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.3	0.0
Indifference point function ln k	0.1	0.3	0.5	0.3	0.7
Indifference point function log k	0.1	0.3	0.5	0.3	0.7
Patch foraging total patch changes 0 sec	0.7	2.1	4.0	2.0	0.5
Patch foraging total patch changes 12 sec	0.6	0.8	1.4	1.2	0.3
Patch foraging total patch changes 18 sec	0.7	1.5	2.4	1.6	-0.8
Patch foraging total patch changes 24 sec	0.2	0.7	1.2	0.3	1.1
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	0.6	-0.1
Patch foraging time to switch 0 sec	0.3	1.1	1.1	1.0	-1.0
Patch foraging water rate 0 sec	0.2	0.8	1.3	-0.6	1.1
Patch foraging water rate 12 sec	0.3	1.1	1.5	-0.8	1.2
Patch foraging water rate 18 sec	1.5	3.4	4.7	-2.2	1.4
Patch foraging water rate 24 sec	0.2	0.2	0.4	-0.7	-0.1
Patch foraging water rate 6 sec	2.4	3.5	5.0	-1.4	2.2
Seeking ratio, delayed vs. immediate footshock	0.5	0.7	1.2	1.1	-0.4
Distance traveled before self-admin	0.8	1.7	3.0	-0.7	1.7
Distance traveled after self-admin	1.4	2.4	3.4	-1.8	1.2
Extensor digitorum longus weight	10.5	41.8	50.8	-7.1	5.7
Bone: elastic displacement	0.3	0.4	0.9	0.9	0.1
Bone: elastic work	0.6	0.7	0.9	0.9	0.8
Bone: endosteal estimation	0.1	0.4	0.7	-0.2	0.8
Bone: endosteal perimeter	0.2	0.5	1.0	-0.0	1.0
Epididymis fat weight	0.4	2.2	2.5	1.6	-1.4
Delta time in closed arm before/after self-admin	2.9	2.7	4.7	2.2	-0.9
Delta time in open arm before/after self-admin	0.0	0.1	0.1	-0.3	0.0
Diff in mean of infusions in LGA sessions	0.5	0.9	0.9	-1.0	0.9
Delay discount exponential model param	0.3	0.4	0.5	0.5	-0.7
Extinction: sum of active levers before priming	1.2	1.9	2.5	1.6	-1.1
Active lever presses in extinction session 6	0.8	0.8	1.1	0.7	-1.0
Bone: final force	0.1	0.2	0.4	-0.3	0.6
Bone: final moment	0.2	0.3	0.6	-0.1	0.8
Food consumed during 24 hour testing period	0.2	0.4	0.6	0.8	0.2
Glucose	0.2	0.3	0.5	-0.2	-0.7
Heart weight	0.3	0.4	0.8	0.9	-0.3
Delay discount hyperbolic model param	0.4	0.5	0.7	0.6	-0.8
Intermittent access intake day 1-15 change	0.6	3.0	3.4	1.8	-1.6
Intermittent access intake escalation	0.5	3.0	3.8	2.0	-1.5
Intermittent access intake escalation 2	1.0	1.7	1.9	1.2	-1.4
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.1	0.0	-0.3
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.1	0.3	0.1
Intermitt. access escalation Index	0.0	0.1	0.2	-0.1	0.4
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.0	0.1
Intermittent access day 15 total infusions	0.8	1.9	2.8	1.7	-1.0
Intermittent access terminal intake (last 3 days)	0.8	1.4	1.4	1.1	-1.2
Intermittent access total infusions	1.1	1.3	1.4	1.2	-1.2
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.3	0.4
Intermittent access day 15 total locomotion	0.1	0.5	0.5	0.6	-0.7
Intermittent access total locomotion	0.1	0.1	0.2	0.4	-0.3
Intermittent access standard deviation	0.0	0.2	0.4	0.6	-0.3
Left kidney weight	0.1	0.6	1.2	-0.3	1.1
Right kidney weight	0.2	1.2	2.4	0.1	1.6
Cocaine induced anxiety	0.3	0.9	1.7	0.3	1.3
Post-drug Anxiety	0.8	0.9	1.8	1.3	0.4
Baseline Anxiety	0.5	0.8	1.3	0.5	-1.1
Tail length	0.3	1.4	2.6	1.6	-0.3
Length with tail	0.2	1.0	2.1	-0.2	1.4
Length without tail	1.4	7.3	8.1	-2.5	2.9
Times rat made contact with spout	0.5	0.6	0.7	0.7	-0.8
Lifetime Intake	0.7	0.9	0.9	0.9	-1.0
Liver weight, left	2.3	3.9	5.8	-1.4	2.4
Liver weight, right	0.4	0.7	1.0	-1.0	0.6
Locomotor activity	4.2	6.5	12.2	-1.0	3.5
Locomotor testing distance	1.1	2.6	4.5	0.9	2.1
Locomotor testing rearing	0.9	3.3	5.0	1.3	2.2
Locomotion in novel chamber	0.3	0.4	0.8	0.9	-0.3
Locomotion in novel chamber post-restriction	0.3	0.9	1.2	-1.1	0.8
Fecal boli incidents, locomotor time 1	0.5	1.4	1.7	-1.0	1.3
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	-0.6	-0.0
Time >=10cm from walls, locomotor time 1	0.7	0.9	1.3	1.2	-0.6
Bouts of movement, locomotor time 1	3.0	3.9	5.8	-2.4	1.4
Total resting periods, locomotor time 1	3.1	3.6	5.9	-2.4	1.1
Rest time, locomotor task time 1	1.0	1.6	2.8	-1.7	0.7
Distance moved, locomotor task time 1	1.0	2.8	3.6	1.9	-1.4
Vertical activity count, locomotor time 1	0.1	0.9	1.7	1.3	0.1
Time >=10cm from walls, locomotor time 2	0.1	0.4	0.5	-0.7	0.5
Bouts of movement, locomotor time 2	1.1	3.8	5.9	-2.4	1.3
Total resting periods, locomotor time 2	1.0	4.1	6.5	-2.5	1.3
Rest time, locomotor task time 2	0.6	1.0	1.9	-1.4	0.1
Distance moved, locomotor task time 2	2.0	2.6	4.7	2.2	-0.8
Vertical activity count, locomotor time 2	0.2	0.6	1.0	1.0	0.4
Light reinforcement 1	1.1	5.0	5.6	2.1	-2.4
Light reinforcement 2	1.3	2.9	5.3	0.7	-2.3
Bone: marrow area	0.1	0.3	0.5	-0.1	0.7
Bone: maximum diameter	0.2	0.5	0.5	-0.7	0.6
Bone: maximum force	0.4	0.8	1.3	-0.4	1.1
Bone: maximum moment	0.5	0.9	1.7	-0.2	1.3
Mean time between licks in bursts	0.3	2.0	3.1	1.8	-1.0
Mean num. licks in bursts	0.1	0.3	0.3	0.6	-0.5
Cd content in liver	1.4	1.5	2.2	-0.9	1.5
Co content in liver	3.5	4.2	6.6	-2.6	1.3
Cu content in liver	0.3	0.3	0.5	-0.7	0.3
Fe content in liver	1.2	1.5	2.1	1.4	-1.0
K content in liver	1.2	1.2	1.5	1.0	-1.2
Mg content in liver	2.2	2.5	2.6	1.6	-1.5
Mn content in liver	1.9	2.2	3.0	1.7	-1.1
Na content in liver	2.0	2.3	4.3	-0.6	2.1
Rb content in liver	0.2	0.2	0.5	-0.0	-0.7
Se content in liver	1.2	1.4	2.4	1.5	0.7
Sr content in liver	0.1	0.0	0.1	0.3	0.2
Zn content in liver	0.2	0.2	0.4	0.6	0.3
Bone: minimum diameter	0.4	0.8	1.6	-0.2	1.3
Time in familiar zone, hab. session 1	0.1	0.1	0.1	-0.3	-0.2
Time in novel zone, hab. session 1	0.8	0.9	1.5	-1.2	0.5
Total zone transitions, hab. session 1	0.4	0.5	1.0	-0.2	1.0
Total locomotion distance, hab. session 1	0.3	0.4	0.7	0.4	0.8
Locomotion velocity, hab. session 1	0.6	0.9	1.1	0.8	1.0
Time in familiar zone, hab. session 2	1.3	1.5	3.0	-1.7	0.1
Time in novel zone, hab. session 2	0.5	0.5	1.1	1.0	0.0
Total zone transitions, hab. session 2	2.2	2.8	4.7	-1.0	2.2
Total locomotion distance, hab. session 2	0.7	0.9	1.6	-0.3	1.3
Locomotion velocity, hab. session 2	1.2	1.6	3.0	-0.5	1.7
Novel to familiar place preference ratio	0.9	1.1	2.0	1.4	-0.5
Novelty place preference	0.7	0.9	1.5	1.2	-0.4
Time in novel zone, NPP test	0.4	0.4	0.8	0.9	-0.2
Total zone transitions, NPP test	0.3	0.5	0.6	0.8	0.6
Total locomotion distance, NPP test	1.9	2.6	5.0	2.2	-0.4
Locomotion velocity, NPP test	1.8	2.6	4.9	2.2	-0.4
Intraocular pressure	0.3	0.5	0.9	0.9	-0.5
Delta distance traveled before/after self-admin	2.1	2.3	4.6	-2.1	0.2
Delta ambulatory time before/after self-admin	1.4	2.5	4.7	-2.2	0.4
Parametrial fat weight	1.4	3.3	4.2	2.1	-1.6
Pavlov. Cond. lever latency	0.1	0.2	0.3	-0.2	-0.6
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.2	-0.1
Pavlov. Cond. change in total contacts	1.3	1.4	2.1	-0.8	1.5
Pavlov. Cond. index score	0.2	0.2	0.4	-0.1	0.7
Pavlov. Cond. latency score	0.1	0.2	0.3	0.0	0.6
Pavlov. Cond. lever contacts	0.1	0.1	0.1	0.3	0.4
Pavlov. Cond. magazine entry number	0.3	0.4	0.5	0.6	-0.7
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.3	0.6	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.6	-0.3	0.8
Pavlov. Cond. response bias	0.2	0.2	0.3	-0.3	0.5
Pavlov. Cond. lever latency	1.1	1.5	2.9	0.4	-1.7
Pavlov. Cond. magazine entry latency	0.2	0.3	0.3	0.5	0.5
Pavlov. Cond. change in total contacts	1.0	2.4	3.4	-1.1	1.9
Pavlov. Cond. index score	0.9	1.4	2.7	-0.4	1.6
Pavlov. Cond. latency score	0.8	1.2	2.4	-0.2	1.5
Pavlov. Cond. lever contacts	0.8	1.2	2.4	-0.1	1.5
Pavlov. Cond. magazine entry number	0.1	0.2	0.2	-0.3	-0.4
Pavlov. Cond. intertrial magazine entries	2.9	6.2	7.9	2.8	-2.1
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.4	2.5	-0.5	1.6
Pavlov. Cond. response bias	0.9	1.3	2.6	-0.2	1.6
Time in closed arm before self-admin	0.8	1.4	2.5	-1.6	0.6
Time in closed arm after self-admin	0.0	0.0	0.0	-0.2	0.1
Time in open arm before self-admin	0.1	0.1	0.2	0.1	0.4
Time in open arm after self-admin	0.0	0.1	0.1	0.3	0.1
Bone: periosteal estimation	0.1	0.3	0.6	-0.1	0.8
Bone: periosteal perimeter	0.1	0.2	0.5	-0.1	0.7
Bone: post-yield work	0.3	0.5	0.8	0.3	-0.9
Progressive ratio test 1 active lever presses	0.1	0.3	0.3	-0.5	-0.5
Progressive ratio test 1 breakpoint	0.2	0.3	0.4	-0.6	-0.4
Progressive ratio test 1 inactive lever presses	0.5	1.3	1.6	1.0	-1.3
Progressive ratio test 2 active lever presses	0.1	0.2	0.4	0.0	-0.6
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.0	-0.5
Progressive ratio test 2 inactive lever presses	0.1	0.4	0.4	0.6	-0.6
Incentive Sensitization - Responses	0.1	0.2	0.3	0.6	-0.4
Incentive Sensitization - Breakpoint	0.1	0.3	0.5	0.7	-0.4
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.6	0.2	-0.7
Progressive ratio	0.0	0.0	0.0	-0.2	-0.1
Food seeking constrained by brief footshock	2.0	2.5	4.7	-2.2	-0.5
Seeking ratio, punishment vs. effort	0.3	0.8	1.5	-1.2	-0.0
Retroperitoneal fat weight	0.1	0.5	0.8	0.5	-0.9
Reaction time number correct	0.2	0.7	1.4	-1.2	0.4
Reaction time mean minus median	0.1	0.4	0.8	-0.2	0.9
Reaction time mean minus median AUC	0.0	0.2	0.3	-0.2	0.6
Reaction time num false alarms	0.2	0.3	0.4	-0.3	0.7
Reaction time num false alarms AUC	0.1	0.2	0.3	-0.2	0.5
Reaction time trials correct on left	0.2	0.7	1.4	-1.2	0.4
Reaction time trials on left	0.2	0.6	1.1	-1.0	0.2
Reaction time mean	0.1	0.3	0.4	-0.4	0.6
Reaction time mean AUC	0.2	0.5	0.8	-0.5	0.9
Median of all reaction times	0.1	0.1	0.2	-0.4	0.4
Reaction time omissions	1.3	2.2	2.5	1.6	-1.4
Reaction time false alarm rate	0.0	0.1	0.1	0.4	0.1
Reaction time premature initiation rate	1.2	1.9	3.4	-1.8	0.6
Reaction time premature initiations	0.9	2.7	5.1	-2.3	0.6
Std. dev. reaction times	0.1	0.3	0.6	-0.3	0.8
Reaction time trials completed	0.2	0.6	1.1	-1.0	0.2
Reaction time trials AUC	0.1	0.5	1.0	-1.0	0.2
Run reversals in cocaine runway, females	2.2	2.5	3.4	1.9	-1.3
Run reversals in cocaine runway, males	1.5	1.7	1.8	-1.3	1.2
Latency to leave start box in cocaine runway	0.3	0.5	0.6	-0.8	0.6
Latency to leave start box in cocaine runway, F	1.2	1.4	1.5	-1.2	1.2
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.3	-0.1
Std. dev. time between licks in bursts	0.8	1.5	3.0	1.7	0.3
Total sessions with >9 infusions	0.0	0.0	0.0	-0.2	0.0
Short access day 1 total inactive lever presses	0.1	0.2	0.3	0.5	0.2
Short access day 10 total inactive lever presses	0.0	0.2	0.2	0.4	-0.4
Short access day 1 total infusions	0.0	0.1	0.1	-0.4	-0.2
Short access day 10 total infusions	0.3	0.6	1.0	-0.4	1.0
Short access total infusions	0.0	0.0	0.1	-0.2	0.3
Short access day 1 locomotion	0.8	1.3	1.9	-0.8	1.4
Short access day 10 total locomotion	0.0	0.1	0.2	0.1	0.5
Short access total locomotion	0.4	0.5	1.1	-0.1	1.0
One hour access (0.3 mA shock)	0.5	0.5	1.0	1.0	-0.3
Compulsive drug intake	0.4	0.5	1.0	1.0	0.1
One hour access (shock baseline)	0.0	0.0	0.0	0.1	0.1
Social response proportion	0.6	0.8	1.1	-0.7	-1.0
Social responses	1.1	1.5	1.7	1.1	-1.3
Social time	0.3	0.5	0.8	0.9	0.3
Soleus weight	1.0	2.8	4.2	-2.1	1.2
Bone: stiffness	0.5	1.0	1.1	-1.0	1.0
Tibialis anterior weight	7.1	24.3	26.9	-5.2	4.7
Time to tail flick, vehicle, before self-admin	0.8	1.0	1.0	1.0	-1.0
Time to tail flick, vehicle, after self-admin	0.7	1.4	2.8	-1.7	-0.0
Time to tail flick, test, before self-admin	2.0	2.3	3.6	1.9	-0.9
Time to tail flick, test, after self-admin	3.1	3.3	5.0	1.3	-2.2
Delta time to tail flick, vehicle, before/after SA	0.3	0.4	0.6	-0.8	-0.3
Delta time to tail flick, test, before/after SA	0.9	1.1	2.2	-0.3	-1.5
Tibia length	1.1	3.2	6.1	2.5	0.4
Ambulatory time before self-admin	0.3	0.8	1.5	-0.3	1.2
Ambulatory time after self-admin	3.2	5.1	6.4	-2.5	2.0
Bone: tissue strength	0.0	0.0	0.1	0.3	0.1
Total heroin consumption	0.6	0.7	1.0	-0.7	1.0
Bone: trabecular number	1.4	2.7	3.8	1.9	-1.3
Bone: trabecular spacing	1.6	2.4	3.2	-1.8	1.3
Bone: trabecular thickness	0.7	1.0	1.7	1.3	-0.6
Bone: trabecular tissue density	1.1	1.8	2.1	-1.3	1.4
Water consumed over 24 hours	0.8	1.6	1.8	-1.2	1.3
Number of responses in last shaping day	0.4	0.5	0.5	-0.7	0.7