Hub : Genes

Tcirg1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Tcirg1 0.13 0.09 1.4e-03 0.01 0.03 0.03 0.01 1.7e-02 4.3e-04 4.1e-04 1.3e-02
2 PL gene expression Tcirg1 0.03 0.03 6.9e-03 0 0.01 0.01 0.01 1.0e-01 1.1e-02 1.8e-02 2.8e-02
3 Liver gene expression Tcirg1 0.31 0.13 0.0e+00 0.16 0.15 0.16 0.16 1.8e-17 9.2e-17 4.4e-17 3.2e-17
4 NAcc gene expression Tcirg1 0.02 0.02 7.8e-03 0.01 0.01 0 0.01 2.3e-02 8.8e-03 8.1e-02 1.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density0.61.03.4-0.10.3-0.61.8
Area under the delay curve0.10.10.3-0.1-0.20.10.5
BMI with tail1.34.610.50.91.6-2.13.2
BMI without tail1.33.96.41.11.9-2.12.5
Body weight3.013.015.23.23.6-3.73.9
Weight adjusted by age1.01.52.01.41.2-1.40.9
Bone surface2.44.39.21.21.6-2.03.0
Bone volume0.71.23.60.30.6-0.91.9
Breakpoint value in progressive ratio session2.42.93.31.61.7-1.81.7
Number of licking bursts0.00.00.10.10.0-0.00.2
Context. condit. distance diff. score1.11.31.7-1.3-1.21.1-0.9
Locomotion velocity, session 10.00.00.00.2-0.00.20.0
Locomotion distance, session 10.40.51.70.30.3-0.41.3
Locomotion velocity, session 22.42.83.31.81.7-1.61.5
Locomotion distance, session 20.91.21.91.10.9-0.91.4
Locomotion velocity, session 30.20.20.6-0.4-0.30.20.7
Locomotion distance, session 30.00.00.00.0-0.10.10.2
Stereotopy head waving bouts, day 30.40.51.1-1.1-0.70.40.3
Stereotopy head waving duration, day 30.91.11.7-1.3-1.21.0-0.5
Locomotion velocity, session 70.20.20.4-0.6-0.2-0.10.6
Locomotion distance, session 70.30.30.60.40.5-0.50.8
Stereotopy head waving bouts, day 70.40.41.0-1.0-0.60.30.3
Stereotopy head waving duration, day 70.50.61.70.00.4-0.71.3
Locomotion velocity, session 81.51.81.91.21.4-1.41.3
Locomotion distance, session 80.20.30.5-0.5-0.70.7-0.2
Degree of sensitization distance0.30.30.70.10.5-0.60.8
Degree of sensitization stereotypy0.20.20.60.00.2-0.40.8
Conditioned locomotion2.63.05.22.31.9-1.60.7
Cocaine response after cond. corrected0.10.10.2-0.4-0.40.3-0.2
Cocaine response after cond. not corrected0.10.20.3-0.6-0.40.3-0.0
Cocaine response before conditioning0.00.10.10.10.1-0.30.4
Saline control response3.14.24.81.82.1-2.22.0
Bone: connectivity density2.43.78.41.01.5-1.82.9
Bone: cortical apparent density0.40.50.70.90.8-0.80.3
Bone: cortical area0.71.12.51.61.0-0.90.4
Bone: cortical porosity0.00.00.10.30.1-0.10.2
Bone: cortical porosity0.40.40.70.80.6-0.50.6
Bone: cortical thickness5.48.916.24.03.1-2.71.5
Bone: cortical thickness2.22.64.12.01.7-1.51.1
Bone: cortical tissue density0.60.81.01.01.0-1.00.4
Condit. Reinf. active minus inactive responses0.10.10.3-0.10.1-0.30.6
Condit. Reinf. active-inactive response ratio0.10.10.4-0.6-0.20.10.2
Condit. Reinf. active responses0.00.00.0-0.1-0.0-0.10.1
Condit. Reinf. inactive responses0.10.10.2-0.2-0.30.2-0.4
Incentive salience index mean0.10.10.30.20.2-0.30.6
Condit. Reinf. lever presses0.10.10.50.70.2-0.10.1
Condit. Reinf. active minus inactive responses0.60.71.2-1.1-1.00.9-0.0
Condit. Reinf. active-inactive response ratio1.92.22.8-1.5-1.71.7-1.0
Condit. Reinf. active responses0.20.30.5-0.7-0.40.20.7
Condit. Reinf. inactive responses0.91.22.30.50.9-1.11.5
Condit. Reinf. lever presses0.60.81.90.40.6-0.81.4
Condit. Reinf. lever reinforcers received0.20.30.9-0.5-0.2-0.11.0
Conditioned reinforcement - actives0.20.40.9-0.6-0.30.4-1.0
Conditioned reinforcement - inactives3.14.56.4-2.5-2.21.9-1.8
Conditioned locomotion8.611.213.6-2.8-3.53.4-3.7
Patch foraging indifference point 0 sec0.30.61.4-1.2-0.70.6-0.5
Patch foraging indifference point AUC0.81.21.81.31.2-1.10.6
Delay disc. indifference point, 0s delay0.30.30.6-0.8-0.40.30.7
Delay disc. indifference point, 16s delay1.11.21.7-0.8-1.31.2-1.0
Delay disc. indifference point, 2s delay0.30.40.8-0.5-0.90.6-0.2
Delay disc. indifference point, 24s delay0.10.10.30.60.40.0-0.0
Delay disc. indifference point, 4s delay0.10.10.30.4-0.0-0.30.5
Delay disc. indifference point, 8s delay0.10.10.3-0.20.10.00.5
Indifference point function ln k3.86.77.2-2.7-2.62.6-2.5
Indifference point function log k3.86.77.2-2.7-2.62.6-2.5
Patch foraging total patch changes 0 sec0.10.20.5-0.7-0.30.3-0.5
Patch foraging total patch changes 12 sec2.53.23.61.61.9-1.91.7
Patch foraging total patch changes 18 sec0.20.30.50.10.6-0.70.6
Patch foraging total patch changes 24 sec0.50.91.30.91.1-1.00.6
Patch foraging total patch changes 6 sec0.71.12.00.51.0-1.11.4
Patch foraging time to switch 0 sec1.02.14.80.91.0-1.42.2
Patch foraging water rate 0 sec2.96.111.5-1.4-2.02.6-3.4
Patch foraging water rate 12 sec4.49.216.0-1.6-2.73.3-4.0
Patch foraging water rate 18 sec1.21.92.9-0.5-1.31.6-1.7
Patch foraging water rate 24 sec2.12.96.0-0.3-1.32.0-2.5
Patch foraging water rate 6 sec1.31.94.7-0.5-1.01.4-2.2
Seeking ratio, delayed vs. immediate footshock0.10.20.3-0.6-0.20.10.6
Distance traveled before self-admin0.10.10.30.10.0-0.00.5
Distance traveled after self-admin0.00.00.0-0.00.1-0.10.2
Extensor digitorum longus weight7.730.333.55.75.8-5.74.7
Bone: elastic displacement0.50.61.11.00.30.1-1.0
Bone: elastic work2.33.05.32.31.9-1.50.9
Bone: endosteal estimation1.63.45.2-2.3-2.01.9-0.9
Bone: endosteal perimeter3.37.111.3-3.4-2.92.6-1.3
Epididymis fat weight4.515.417.0-3.5-4.14.1-3.9
Delta time in closed arm before/after self-admin1.61.51.91.41.3-1.30.9
Delta time in open arm before/after self-admin0.00.00.1-0.0-0.30.20.2
Diff in mean of infusions in LGA sessions0.91.01.51.21.0-1.00.8
Delay discount exponential model param0.10.10.3-0.10.10.0-0.5
Extinction: sum of active levers before priming1.92.13.51.11.4-1.31.9
Active lever presses in extinction session 61.61.62.31.51.2-1.40.8
Bone: final force1.42.32.51.51.4-1.51.6
Bone: final moment1.42.22.41.61.4-1.41.5
Food consumed during 24 hour testing period0.30.30.7-0.1-0.50.6-0.8
Glucose2.03.14.4-2.1-2.11.8-0.7
Heart weight0.50.71.8-1.4-0.90.40.3
Delay discount hyperbolic model param0.10.10.2-0.00.2-0.0-0.4
Intermittent access intake day 1-15 change2.04.25.2-1.3-2.22.2-2.3
Intermittent access intake escalation1.73.64.8-1.1-2.02.0-2.2
Intermittent access intake escalation 22.52.83.4-1.1-1.81.8-1.8
Intermitt. access day 1 inactive lever presses0.00.10.3-0.5-0.10.3-0.1
Intermitt. access day 15 inactive lever presses1.32.64.1-2.0-1.71.5-1.0
Intermitt. access escalation Index2.13.04.7-1.1-1.71.7-2.2
Intermittent access day 1 total infusions2.13.58.1-2.8-1.91.4-0.4
Intermittent access day 15 total infusions6.19.111.3-3.4-3.23.0-2.4
Intermittent access terminal intake (last 3 days)5.57.210.4-3.2-2.92.5-1.9
Intermittent access total infusions3.54.16.9-2.6-2.21.8-1.2
Intermittent access day 1 locomotion1.41.74.0-2.0-1.41.0-0.4
Intermittent access day 15 total locomotion4.07.29.4-2.8-3.12.6-2.3
Intermittent access total locomotion7.79.212.4-3.2-3.52.9-2.4
Intermittent access standard deviation0.61.11.6-0.9-1.31.1-0.9
Left kidney weight1.04.75.7-1.8-2.42.4-2.1
Right kidney weight0.73.14.1-1.0-1.82.0-2.0
Cocaine induced anxiety0.00.00.0-0.1-0.20.10.1
Post-drug Anxiety0.40.40.60.30.7-0.60.8
Baseline Anxiety0.40.50.80.40.9-0.70.6
Tail length0.83.34.42.12.1-1.91.0
Length with tail2.611.414.53.83.6-3.42.5
Length without tail2.58.010.23.23.0-2.82.2
Times rat made contact with spout0.50.51.20.40.6-0.71.1
Lifetime Intake2.32.85.7-2.4-1.71.4-0.9
Liver weight, left0.30.61.3-0.2-0.60.8-1.1
Liver weight, right1.11.92.8-1.0-1.31.5-1.7
Locomotor activity0.81.21.9-0.3-1.01.3-1.4
Locomotor testing distance0.91.62.5-0.6-1.11.6-1.6
Locomotor testing rearing0.71.31.9-1.0-1.31.4-0.9
Locomotion in novel chamber6.88.710.0-3.0-3.23.0-2.5
Locomotion in novel chamber post-restriction3.04.95.9-2.0-2.42.3-2.1
Fecal boli incidents, locomotor time 10.00.10.1-0.1-0.30.1-0.3
Change in fecal boli incidents, locomotor task0.10.10.20.10.3-0.20.4
Time >=10cm from walls, locomotor time 12.02.13.9-2.0-1.61.3-0.5
Bouts of movement, locomotor time 11.11.32.61.61.2-1.00.4
Total resting periods, locomotor time 10.50.61.51.20.7-0.60.1
Rest time, locomotor task time 12.02.53.5-1.3-1.41.6-1.9
Distance moved, locomotor task time 10.10.20.70.00.0-0.30.9
Vertical activity count, locomotor time 10.51.11.9-1.4-1.11.0-0.5
Time >=10cm from walls, locomotor time 20.10.20.4-0.1-0.30.3-0.6
Bouts of movement, locomotor time 20.50.81.61.30.8-0.70.6
Total resting periods, locomotor time 20.20.40.91.00.4-0.40.4
Rest time, locomotor task time 22.43.04.7-2.2-1.81.7-1.1
Distance moved, locomotor task time 20.91.11.61.31.2-1.00.5
Vertical activity count, locomotor time 20.20.30.50.70.7-0.2-0.6
Light reinforcement 10.51.11.6-1.0-1.00.9-1.2
Light reinforcement 22.23.44.2-1.7-1.81.8-2.1
Bone: marrow area1.73.65.5-2.3-2.11.9-0.9
Bone: maximum diameter0.10.20.3-0.1-0.40.5-0.6
Bone: maximum force1.32.45.01.11.2-1.42.2
Bone: maximum moment1.32.34.61.11.2-1.32.1
Mean time between licks in bursts0.30.91.10.91.0-1.00.8
Mean num. licks in bursts0.00.00.1-0.20.1-0.10.3
Cd content in liver2.12.42.6-1.5-1.61.6-1.4
Co content in liver0.50.51.80.0-0.30.6-1.3
Cu content in liver0.00.10.1-0.3-0.20.2-0.3
Fe content in liver0.10.10.30.50.4-0.20.3
K content in liver0.40.40.80.50.5-0.60.9
Mg content in liver0.50.50.9-0.9-0.80.6-0.3
Mn content in liver2.32.52.91.41.7-1.71.6
Na content in liver0.10.20.40.60.2-0.0-0.5
Rb content in liver1.31.52.5-1.6-1.41.2-0.6
Se content in liver0.30.40.7-0.9-0.60.5-0.1
Sr content in liver2.21.92.71.61.5-1.40.8
Zn content in liver0.40.40.60.80.7-0.70.3
Bone: minimum diameter0.91.72.5-1.4-1.61.5-0.3
Time in familiar zone, hab. session 10.60.60.8-0.9-0.80.8-0.4
Time in novel zone, hab. session 10.10.10.10.30.3-0.20.1
Total zone transitions, hab. session 10.40.60.80.70.7-0.80.9
Total locomotion distance, hab. session 10.40.60.8-0.7-0.90.9-0.6
Locomotion velocity, hab. session 10.10.10.2-0.2-0.40.4-0.3
Time in familiar zone, hab. session 20.70.71.41.20.9-0.80.3
Time in novel zone, hab. session 20.30.30.8-0.9-0.40.30.4
Total zone transitions, hab. session 21.21.54.6-0.20.7-1.02.1
Total locomotion distance, hab. session 20.20.30.5-0.7-0.30.10.7
Locomotion velocity, hab. session 20.30.41.0-1.0-0.60.40.3
Novel to familiar place preference ratio0.20.20.4-0.30.2-0.40.6
Novelty place preference0.10.20.4-0.7-0.2-0.10.4
Time in novel zone, NPP test0.10.20.4-0.7-0.1-0.20.4
Total zone transitions, NPP test0.81.22.50.70.9-1.01.6
Total locomotion distance, NPP test0.10.10.1-0.2-0.30.30.2
Locomotion velocity, NPP test0.00.10.1-0.1-0.30.40.1
Intraocular pressure0.50.71.7-0.1-0.50.8-1.3
Delta distance traveled before/after self-admin0.00.00.00.00.2-0.2-0.1
Delta ambulatory time before/after self-admin0.00.10.10.10.4-0.3-0.1
Parametrial fat weight2.96.88.8-2.5-3.02.8-2.1
Pavlov. Cond. lever latency0.40.50.5-0.7-0.60.7-0.7
Pavlov. Cond. magazine entry latency0.10.10.2-0.5-0.50.20.3
Pavlov. Cond. change in total contacts0.40.40.7-0.8-0.80.6-0.3
Pavlov. Cond. index score0.00.00.10.2-0.20.1-0.1
Pavlov. Cond. latency score0.00.00.00.1-0.20.00.1
Pavlov. Cond. lever contacts0.10.10.10.40.2-0.30.3
Pavlov. Cond. magazine entry number0.00.10.1-0.00.3-0.20.3
Pavlov. Cond. intertrial magazine entries0.20.20.6-0.1-0.20.3-0.8
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.1-0.20.1-0.0
Pavlov. Cond. response bias0.00.00.10.1-0.20.1-0.3
Pavlov. Cond. lever latency0.00.00.1-0.3-0.10.1-0.1
Pavlov. Cond. magazine entry latency3.13.76.31.31.7-1.92.5
Pavlov. Cond. change in total contacts0.10.20.70.10.2-0.30.9
Pavlov. Cond. index score0.70.91.80.60.8-0.91.3
Pavlov. Cond. latency score0.50.71.30.50.7-0.81.1
Pavlov. Cond. lever contacts0.00.10.20.40.2-0.20.2
Pavlov. Cond. magazine entry number3.74.67.6-1.5-2.02.2-2.8
Pavlov. Cond. intertrial magazine entries1.21.82.5-1.1-1.31.3-1.6
Pavlov. Cond. lever-magazine prob. diff.1.01.32.30.81.0-1.21.5
Pavlov. Cond. response bias0.71.01.80.80.8-0.91.4
Time in closed arm before self-admin0.81.01.6-1.0-1.20.9-0.6
Time in closed arm after self-admin0.00.00.10.0-0.2-0.0-0.3
Time in open arm before self-admin0.70.81.40.81.2-0.90.5
Time in open arm after self-admin0.60.60.90.60.8-0.70.9
Bone: periosteal estimation0.10.30.4-0.4-0.60.6-0.3
Bone: periosteal perimeter0.20.30.5-0.7-0.60.50.1
Bone: post-yield work1.32.04.1-2.0-1.20.61.4
Progressive ratio test 1 active lever presses0.20.31.1-1.0-0.10.1-0.3
Progressive ratio test 1 breakpoint0.20.20.9-1.0-0.10.1-0.2
Progressive ratio test 1 inactive lever presses0.10.20.8-0.9-0.10.2-0.1
Progressive ratio test 2 active lever presses2.53.05.4-2.3-1.61.5-1.2
Progressive ratio test 2 breakpoint2.42.85.0-2.2-1.61.5-1.2
Progressive ratio test 2 inactive lever presses6.811.115.0-3.9-3.53.1-2.8
Incentive Sensitization - Responses0.20.20.6-0.8-0.2-0.10.4
Incentive Sensitization - Breakpoint0.20.30.8-0.9-0.40.10.2
Sum of active levers in priming session hrs 5-60.50.51.00.80.4-0.0-1.0
Progressive ratio0.91.54.6-0.20.6-0.92.1
Food seeking constrained by brief footshock0.10.10.3-0.10.3-0.30.6
Seeking ratio, punishment vs. effort0.81.13.2-0.1-0.70.9-1.8
Retroperitoneal fat weight8.435.940.4-5.7-6.46.2-5.7
Reaction time number correct0.40.82.11.40.9-0.60.2
Reaction time mean minus median1.23.04.11.51.7-1.72.0
Reaction time mean minus median AUC1.12.83.31.81.7-1.51.6
Reaction time num false alarms0.10.20.30.60.5-0.3-0.3
Reaction time num false alarms AUC0.61.01.41.11.2-1.00.4
Reaction time trials correct on left0.40.82.11.40.9-0.60.2
Reaction time trials on left0.61.02.51.61.0-0.70.3
Reaction time mean0.10.10.2-0.4-0.1-0.00.4
Reaction time mean AUC0.10.10.2-0.5-0.30.10.3
Median of all reaction times0.30.40.9-1.0-0.60.40.0
Reaction time omissions2.53.63.81.82.0-2.01.8
Reaction time false alarm rate0.10.10.20.20.5-0.40.0
Reaction time premature initiation rate3.04.24.82.02.2-2.02.0
Reaction time premature initiations3.76.78.72.92.8-2.42.1
Std. dev. reaction times0.50.91.50.70.9-0.81.2
Reaction time trials completed0.61.02.51.61.0-0.70.3
Reaction time trials AUC0.40.82.01.40.9-0.60.3
Run reversals in cocaine runway, females0.90.91.70.70.7-1.01.3
Run reversals in cocaine runway, males0.20.20.30.60.4-0.2-0.2
Latency to leave start box in cocaine runway0.30.30.6-0.8-0.70.50.2
Latency to leave start box in cocaine runway, F0.10.10.2-0.1-0.40.10.4
Latency to leave start box in cocaine runway, M0.10.10.2-0.5-0.00.20.1
Std. dev. time between licks in bursts0.91.23.01.71.1-0.80.2
Total sessions with >9 infusions0.20.20.5-0.70.2-0.30.5
Short access day 1 total inactive lever presses2.12.73.9-2.0-1.61.5-1.4
Short access day 10 total inactive lever presses0.00.00.0-0.2-0.00.10.1
Short access day 1 total infusions1.52.04.2-2.0-1.31.3-0.9
Short access day 10 total infusions0.70.92.9-1.7-0.60.10.5
Short access total infusions0.50.72.4-1.6-0.40.10.3
Short access day 1 locomotion1.11.32.2-1.5-1.21.0-0.8
Short access day 10 total locomotion0.61.02.4-1.6-1.00.7-0.4
Short access total locomotion1.31.53.4-1.8-1.20.9-0.6
One hour access (0.3 mA shock)6.06.99.5-3.1-2.62.6-2.1
Compulsive drug intake2.63.14.91.82.2-1.61.3
One hour access (shock baseline)6.610.112.0-3.5-3.43.1-2.7
Social response proportion0.60.71.20.90.7-0.61.1
Social responses0.70.91.71.30.9-0.80.6
Social time0.60.80.90.90.9-0.90.9
Soleus weight4.212.516.8-2.8-3.43.7-4.1
Bone: stiffness0.81.23.30.60.7-0.91.8
Tibialis anterior weight9.130.839.46.36.0-5.83.8
Time to tail flick, vehicle, before self-admin0.40.41.20.40.1-0.51.1
Time to tail flick, vehicle, after self-admin1.31.83.60.81.1-1.21.9
Time to tail flick, test, before self-admin0.60.61.2-1.1-1.10.50.1
Time to tail flick, test, after self-admin0.00.00.10.20.1-0.3-0.1
Delta time to tail flick, vehicle, before/after SA0.80.71.10.50.9-0.91.1
Delta time to tail flick, test, before/after SA1.11.22.11.41.3-0.9-0.3
Tibia length0.30.92.51.60.8-0.5-0.3
Ambulatory time before self-admin0.10.10.30.3-0.10.10.6
Ambulatory time after self-admin0.60.71.2-0.9-1.10.9-0.4
Bone: tissue strength0.10.10.2-0.2-0.50.4-0.1
Total heroin consumption4.04.75.71.82.4-2.32.1
Bone: trabecular number0.71.13.6-0.00.4-0.81.9
Bone: trabecular spacing0.30.41.2-0.4-0.40.5-1.1
Bone: trabecular thickness0.30.40.6-0.8-0.80.60.3
Bone: trabecular tissue density5.98.712.6-2.1-2.93.1-3.6
Water consumed over 24 hours0.81.11.70.71.0-1.11.3
Number of responses in last shaping day0.10.10.1-0.30.4-0.30.1