Hub : Genes

Tcirg1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Tcirg1 0.03 0.03 6.9e-03 0 0.01 0.01 0.01 1.0e-01 1.1e-02 2.6e-02 3.0e-02
2 Adipose gene expression Tcirg1 0.13 0.09 1.4e-03 0.01 0.03 0.03 0.01 1.7e-02 4.3e-04 4.1e-04 1.4e-02
3 Liver gene expression Tcirg1 0.31 0.13 0.0e+00 0.16 0.15 0.16 0.16 1.8e-17 9.2e-17 4.4e-17 3.2e-17
4 NAcc gene expression Tcirg1 0.02 0.02 7.8e-03 0.01 0.01 0 0.01 2.3e-02 8.8e-03 8.1e-02 1.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density0.51.03.40.30.30.61.8
Area under the delay curve0.10.10.3-0.20.2-0.10.5
BMI with tail1.34.510.51.6-0.72.13.2
BMI without tail0.73.86.41.9-1.02.12.5
Body weight2.912.715.23.6-3.13.73.9
Weight adjusted by age0.51.52.01.2-1.41.40.9
Bone surface2.14.29.21.6-1.02.03.0
Bone volume0.61.23.60.6-0.10.91.9
Breakpoint value in progressive ratio session1.62.83.31.7-1.51.81.7
Number of licking bursts0.00.00.10.0-0.10.00.2
Context. condit. distance diff. score1.11.31.7-1.21.3-1.1-0.9
Locomotion velocity, session 10.00.00.0-0.0-0.2-0.20.0
Locomotion distance, session 10.40.51.70.3-0.20.41.3
Locomotion velocity, session 22.32.83.11.7-1.81.61.5
Locomotion distance, session 20.81.21.90.9-1.00.91.4
Locomotion velocity, session 30.20.20.6-0.30.5-0.20.7
Locomotion distance, session 30.00.00.0-0.1-0.0-0.10.2
Stereotopy head waving bouts, day 30.40.51.3-0.71.1-0.40.3
Stereotopy head waving duration, day 30.91.11.7-1.21.3-1.0-0.5
Locomotion velocity, session 70.20.20.5-0.20.70.10.6
Locomotion distance, session 70.30.30.60.5-0.30.50.8
Stereotopy head waving bouts, day 70.40.51.2-0.61.1-0.30.3
Stereotopy head waving duration, day 70.50.61.70.40.10.71.3
Locomotion velocity, session 81.41.71.91.4-1.21.41.3
Locomotion distance, session 80.20.30.5-0.70.5-0.7-0.2
Degree of sensitization distance0.30.30.70.5-0.00.60.8
Degree of sensitization stereotypy0.20.20.60.20.00.40.8
Conditioned locomotion2.63.15.31.9-2.31.60.7
Cocaine response after cond. corrected0.10.10.2-0.40.4-0.3-0.2
Cocaine response after cond. not corrected0.10.20.4-0.40.6-0.3-0.0
Cocaine response before conditioning0.00.10.10.1-0.10.30.4
Saline control response3.04.14.82.1-1.72.22.0
Bone: connectivity density2.33.68.41.5-0.81.82.9
Bone: cortical apparent density0.30.50.80.8-0.90.80.3
Bone: cortical area0.71.12.51.0-1.60.90.4
Bone: cortical porosity0.00.00.10.1-0.30.10.2
Bone: cortical porosity0.40.40.60.6-0.80.50.6
Bone: cortical thickness5.49.016.43.1-4.02.71.5
Bone: cortical thickness2.12.64.11.7-2.01.51.1
Bone: cortical tissue density0.50.81.01.0-1.01.00.4
Condit. Reinf. active minus inactive responses0.10.10.30.10.10.30.6
Condit. Reinf. active-inactive response ratio0.10.10.4-0.20.6-0.10.2
Condit. Reinf. active responses0.00.00.0-0.00.10.10.1
Condit. Reinf. inactive responses0.10.10.2-0.30.1-0.2-0.4
Incentive salience index mean0.10.10.30.2-0.20.30.6
Condit. Reinf. lever presses0.10.10.50.2-0.70.10.1
Condit. Reinf. active minus inactive responses0.50.81.3-1.01.1-0.9-0.0
Condit. Reinf. active-inactive response ratio1.42.22.8-1.71.5-1.7-1.0
Condit. Reinf. active responses0.20.30.6-0.40.8-0.20.7
Condit. Reinf. inactive responses0.81.12.30.9-0.41.11.5
Condit. Reinf. lever presses0.50.81.90.6-0.30.81.4
Condit. Reinf. lever reinforcers received0.20.30.9-0.20.60.11.0
Conditioned reinforcement - actives0.10.40.9-0.30.5-0.4-1.0
Conditioned reinforcement - inactives1.64.56.1-2.22.5-1.9-1.8
Conditioned locomotion7.411.013.6-3.52.7-3.4-3.7
Patch foraging indifference point 0 sec0.20.61.3-0.71.2-0.6-0.5
Patch foraging indifference point AUC0.51.31.91.2-1.41.10.6
Delay disc. indifference point, 0s delay0.30.40.8-0.40.9-0.30.7
Delay disc. indifference point, 16s delay0.81.21.7-1.30.8-1.2-1.0
Delay disc. indifference point, 2s delay0.30.40.8-0.90.5-0.6-0.2
Delay disc. indifference point, 24s delay0.10.10.40.4-0.6-0.0-0.0
Delay disc. indifference point, 4s delay0.10.10.3-0.0-0.30.30.5
Delay disc. indifference point, 8s delay0.10.10.30.10.3-0.00.5
Indifference point function ln k2.26.66.9-2.62.6-2.6-2.5
Indifference point function log k2.26.66.9-2.62.6-2.6-2.5
Patch foraging total patch changes 0 sec0.10.20.5-0.30.7-0.3-0.5
Patch foraging total patch changes 12 sec2.43.23.61.9-1.71.91.7
Patch foraging total patch changes 18 sec0.10.30.50.6-0.10.70.6
Patch foraging total patch changes 24 sec0.30.91.31.1-1.01.00.6
Patch foraging total patch changes 6 sec0.61.12.01.0-0.51.11.4
Patch foraging time to switch 0 sec0.52.14.81.0-0.71.42.2
Patch foraging water rate 0 sec1.65.911.5-2.01.2-2.6-3.4
Patch foraging water rate 12 sec2.29.016.0-2.71.3-3.3-4.0
Patch foraging water rate 18 sec0.91.92.9-1.30.4-1.6-1.7
Patch foraging water rate 24 sec2.02.96.0-1.30.2-2.0-2.5
Patch foraging water rate 6 sec1.31.94.7-1.00.4-1.4-2.2
Seeking ratio, delayed vs. immediate footshock0.10.20.4-0.20.6-0.10.6
Distance traveled before self-admin0.00.10.30.0-0.10.00.5
Distance traveled after self-admin0.00.00.00.10.10.10.2
Extensor digitorum longus weight7.530.033.55.8-5.65.74.7
Bone: elastic displacement0.50.61.30.3-1.1-0.1-1.0
Bone: elastic work2.33.05.41.9-2.31.50.9
Bone: endosteal estimation1.43.55.3-2.02.3-1.9-0.9
Bone: endosteal perimeter2.97.111.5-2.93.4-2.6-1.3
Epididymis fat weight3.015.117.0-4.13.4-4.1-3.9
Delta time in closed arm before/after self-admin1.61.51.91.3-1.41.30.9
Delta time in open arm before/after self-admin0.00.00.1-0.30.1-0.20.2
Diff in mean of infusions in LGA sessions0.61.01.51.0-1.21.00.8
Delay discount exponential model param0.10.10.30.10.0-0.0-0.5
Extinction: sum of active levers before priming1.32.03.51.4-1.01.31.9
Active lever presses in extinction session 61.51.52.11.2-1.41.40.8
Bone: final force1.32.22.51.4-1.51.51.6
Bone: final moment1.32.12.31.4-1.51.41.5
Food consumed during 24 hour testing period0.20.30.7-0.50.0-0.6-0.8
Glucose2.03.14.6-2.12.1-1.8-0.7
Heart weight0.50.82.0-0.91.4-0.40.3
Delay discount hyperbolic model param0.00.10.20.2-0.00.0-0.4
Intermittent access intake day 1-15 change0.84.15.2-2.21.2-2.2-2.3
Intermittent access intake escalation0.63.54.8-2.01.0-2.0-2.2
Intermittent access intake escalation 21.72.83.4-1.81.0-1.8-1.8
Intermitt. access day 1 inactive lever presses0.00.10.3-0.10.5-0.3-0.1
Intermitt. access day 15 inactive lever presses0.52.64.1-1.72.0-1.5-1.0
Intermitt. access escalation Index0.92.94.7-1.71.0-1.7-2.2
Intermittent access day 1 total infusions1.23.58.4-1.92.9-1.4-0.4
Intermittent access day 15 total infusions3.79.010.9-3.23.3-3.0-2.4
Intermittent access terminal intake (last 3 days)4.17.210.2-2.93.2-2.5-1.9
Intermittent access total infusions3.54.16.9-2.22.6-1.8-1.2
Intermittent access day 1 locomotion1.01.84.1-1.42.0-1.0-0.4
Intermittent access day 15 total locomotion1.97.29.4-3.12.7-2.6-2.3
Intermittent access total locomotion7.79.212.4-3.53.2-2.9-2.4
Intermittent access standard deviation0.21.11.6-1.30.9-1.1-0.9
Left kidney weight0.64.75.7-2.41.7-2.4-2.1
Right kidney weight0.43.04.1-1.80.9-2.0-2.0
Cocaine induced anxiety0.00.00.0-0.20.1-0.10.1
Post-drug Anxiety0.30.40.60.7-0.30.60.8
Baseline Anxiety0.30.50.80.9-0.40.70.6
Tail length0.63.34.42.1-2.11.91.0
Length with tail2.611.314.23.6-3.83.42.5
Length without tail1.57.99.93.0-3.12.82.2
Times rat made contact with spout0.50.51.20.6-0.30.71.1
Lifetime Intake2.32.85.7-1.72.4-1.4-0.9
Liver weight, left0.30.61.3-0.60.2-0.8-1.1
Liver weight, right1.11.82.8-1.30.9-1.5-1.7
Locomotor activity0.81.21.9-1.00.3-1.3-1.4
Locomotor testing distance0.71.62.5-1.10.5-1.6-1.6
Locomotor testing rearing0.41.31.9-1.31.0-1.4-0.9
Locomotion in novel chamber6.48.610.0-3.23.0-3.0-2.5
Locomotion in novel chamber post-restriction1.64.95.9-2.42.0-2.3-2.1
Fecal boli incidents, locomotor time 10.00.10.1-0.30.1-0.1-0.3
Change in fecal boli incidents, locomotor task0.10.10.20.3-0.00.20.4
Time >=10cm from walls, locomotor time 11.72.14.0-1.62.0-1.3-0.5
Bouts of movement, locomotor time 11.01.32.71.2-1.71.00.4
Total resting periods, locomotor time 10.50.61.60.7-1.30.60.1
Rest time, locomotor task time 11.52.43.5-1.41.2-1.6-1.9
Distance moved, locomotor task time 10.10.20.70.00.10.30.9
Vertical activity count, locomotor time 10.21.11.9-1.11.4-1.0-0.5
Time >=10cm from walls, locomotor time 20.10.20.4-0.30.0-0.3-0.6
Bouts of movement, locomotor time 20.20.81.60.8-1.30.70.6
Total resting periods, locomotor time 20.10.40.90.4-0.90.40.4
Rest time, locomotor task time 21.83.04.7-1.82.2-1.7-1.1
Distance moved, locomotor task time 20.81.11.71.2-1.31.00.5
Vertical activity count, locomotor time 20.20.40.60.7-0.80.2-0.6
Light reinforcement 10.21.11.6-1.01.0-0.9-1.2
Light reinforcement 21.53.44.2-1.81.6-1.8-2.1
Bone: marrow area1.53.65.6-2.12.4-1.9-0.9
Bone: maximum diameter0.10.20.3-0.40.1-0.5-0.6
Bone: maximum force1.22.35.01.2-0.91.42.2
Bone: maximum moment1.22.24.61.2-1.01.32.1
Mean time between licks in bursts0.10.81.11.0-0.81.00.8
Mean num. licks in bursts0.00.00.10.10.30.10.3
Cd content in liver2.12.32.6-1.61.5-1.6-1.4
Co content in liver0.50.51.8-0.3-0.2-0.6-1.3
Cu content in liver0.00.10.1-0.20.2-0.2-0.3
Fe content in liver0.10.10.30.4-0.50.20.3
K content in liver0.40.40.80.5-0.50.60.9
Mg content in liver0.50.50.9-0.80.9-0.6-0.3
Mn content in liver2.22.52.91.7-1.31.71.6
Na content in liver0.20.20.40.2-0.60.0-0.5
Rb content in liver1.41.62.6-1.41.6-1.2-0.6
Se content in liver0.30.40.8-0.60.9-0.5-0.1
Sr content in liver2.21.92.81.5-1.71.40.8
Zn content in liver0.40.40.60.7-0.80.70.3
Bone: minimum diameter0.91.72.5-1.61.5-1.5-0.3
Time in familiar zone, hab. session 10.50.60.9-0.80.9-0.8-0.4
Time in novel zone, hab. session 10.10.10.10.3-0.40.20.1
Total zone transitions, hab. session 10.40.60.80.7-0.70.80.9
Total locomotion distance, hab. session 10.40.60.8-0.90.7-0.9-0.6
Locomotion velocity, hab. session 10.10.10.2-0.40.2-0.4-0.3
Time in familiar zone, hab. session 20.70.71.40.9-1.20.80.3
Time in novel zone, hab. session 20.30.30.9-0.41.0-0.30.4
Total zone transitions, hab. session 21.21.64.60.70.31.02.1
Total locomotion distance, hab. session 20.20.30.7-0.30.8-0.10.7
Locomotion velocity, hab. session 20.40.51.2-0.61.1-0.40.3
Novel to familiar place preference ratio0.10.20.40.20.40.40.6
Novelty place preference0.10.20.5-0.20.70.10.4
Time in novel zone, NPP test0.10.20.5-0.10.70.20.4
Total zone transitions, NPP test0.81.22.50.9-0.61.01.6
Total locomotion distance, NPP test0.10.10.1-0.30.2-0.30.2
Locomotion velocity, NPP test0.00.10.1-0.30.1-0.40.1
Intraocular pressure0.40.71.7-0.5-0.0-0.8-1.3
Delta distance traveled before/after self-admin0.00.00.00.2-0.00.2-0.1
Delta ambulatory time before/after self-admin0.00.10.10.4-0.10.3-0.1
Parametrial fat weight2.96.88.8-3.02.5-2.8-2.1
Pavlov. Cond. lever latency0.30.40.5-0.60.7-0.7-0.7
Pavlov. Cond. magazine entry latency0.10.20.3-0.50.5-0.20.3
Pavlov. Cond. change in total contacts0.40.40.8-0.80.9-0.6-0.3
Pavlov. Cond. index score0.00.00.1-0.2-0.1-0.1-0.1
Pavlov. Cond. latency score0.00.00.0-0.2-0.1-0.00.1
Pavlov. Cond. lever contacts0.10.10.10.2-0.30.30.3
Pavlov. Cond. magazine entry number0.00.10.10.3-0.00.20.3
Pavlov. Cond. intertrial magazine entries0.20.20.6-0.20.0-0.3-0.8
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.2-0.1-0.1-0.0
Pavlov. Cond. response bias0.00.00.1-0.2-0.1-0.1-0.3
Pavlov. Cond. lever latency0.00.00.1-0.10.3-0.1-0.1
Pavlov. Cond. magazine entry latency2.53.66.31.7-1.21.92.5
Pavlov. Cond. change in total contacts0.10.20.70.20.00.30.9
Pavlov. Cond. index score0.60.91.80.8-0.50.91.3
Pavlov. Cond. latency score0.40.61.30.7-0.50.81.1
Pavlov. Cond. lever contacts0.00.10.10.2-0.40.20.2
Pavlov. Cond. magazine entry number3.54.57.6-2.01.3-2.2-2.8
Pavlov. Cond. intertrial magazine entries0.81.82.5-1.31.0-1.3-1.6
Pavlov. Cond. lever-magazine prob. diff.0.81.32.31.0-0.71.21.5
Pavlov. Cond. response bias0.71.01.80.8-0.70.91.4
Time in closed arm before self-admin0.61.01.6-1.21.1-0.9-0.6
Time in closed arm after self-admin0.00.00.1-0.2-0.00.0-0.3
Time in open arm before self-admin0.70.81.41.2-0.90.90.5
Time in open arm after self-admin0.50.60.90.8-0.60.70.9
Bone: periosteal estimation0.10.30.4-0.60.4-0.6-0.3
Bone: periosteal perimeter0.10.30.6-0.60.7-0.50.1
Bone: post-yield work1.32.24.9-1.22.2-0.61.4
Progressive ratio test 1 active lever presses0.20.31.0-0.11.0-0.1-0.3
Progressive ratio test 1 breakpoint0.10.20.8-0.10.9-0.1-0.2
Progressive ratio test 1 inactive lever presses0.10.20.8-0.10.9-0.2-0.1
Progressive ratio test 2 active lever presses2.12.95.2-1.62.3-1.5-1.2
Progressive ratio test 2 breakpoint2.12.74.8-1.62.2-1.5-1.2
Progressive ratio test 2 inactive lever presses3.511.014.4-3.53.8-3.1-2.8
Incentive Sensitization - Responses0.10.20.7-0.20.80.10.4
Incentive Sensitization - Breakpoint0.10.30.9-0.40.9-0.10.2
Sum of active levers in priming session hrs 5-60.50.51.00.4-0.90.0-1.0
Progressive ratio0.51.54.60.60.40.92.1
Food seeking constrained by brief footshock0.10.10.30.30.10.30.6
Seeking ratio, punishment vs. effort0.51.13.2-0.7-0.0-0.9-1.8
Retroperitoneal fat weight7.935.540.4-6.45.5-6.2-5.7
Reaction time number correct0.20.82.10.9-1.50.60.2
Reaction time mean minus median0.53.04.11.7-1.41.72.0
Reaction time mean minus median AUC0.42.83.31.7-1.81.51.6
Reaction time num false alarms0.10.20.50.5-0.70.3-0.3
Reaction time num false alarms AUC0.41.01.51.2-1.21.00.4
Reaction time trials correct on left0.20.82.10.9-1.50.60.2
Reaction time trials on left0.31.02.51.0-1.60.70.3
Reaction time mean0.00.10.2-0.10.40.00.4
Reaction time mean AUC0.00.10.2-0.30.5-0.10.3
Median of all reaction times0.20.40.9-0.61.0-0.40.0
Reaction time omissions2.23.63.82.0-1.82.01.8
Reaction time false alarm rate0.10.10.20.5-0.30.40.0
Reaction time premature initiation rate2.74.14.82.2-2.02.02.0
Reaction time premature initiations2.26.68.52.8-2.92.42.1
Std. dev. reaction times0.30.91.50.9-0.70.81.2
Reaction time trials completed0.31.02.51.0-1.60.70.3
Reaction time trials AUC0.20.82.00.9-1.40.60.3
Run reversals in cocaine runway, females0.80.91.70.7-0.61.01.3
Run reversals in cocaine runway, males0.20.20.40.4-0.60.2-0.2
Latency to leave start box in cocaine runway0.30.40.8-0.70.9-0.50.2
Latency to leave start box in cocaine runway, F0.10.10.2-0.40.2-0.10.4
Latency to leave start box in cocaine runway, M0.10.10.3-0.00.5-0.20.1
Std. dev. time between licks in bursts0.71.33.11.1-1.80.80.2
Total sessions with >9 infusions0.20.20.50.20.70.30.5
Short access day 1 total inactive lever presses1.32.73.7-1.61.9-1.5-1.4
Short access day 10 total inactive lever presses0.00.00.0-0.00.2-0.10.1
Short access day 1 total infusions1.02.04.1-1.32.0-1.3-0.9
Short access day 10 total infusions0.61.03.2-0.61.8-0.10.5
Short access total infusions0.50.72.5-0.41.6-0.10.3
Short access day 1 locomotion0.81.32.2-1.21.5-1.0-0.8
Short access day 10 total locomotion0.31.12.5-1.01.6-0.7-0.4
Short access total locomotion1.01.53.4-1.21.8-0.9-0.6
One hour access (0.3 mA shock)5.76.89.2-2.63.0-2.6-2.1
Compulsive drug intake2.13.14.92.2-1.81.61.3
One hour access (shock baseline)3.810.011.5-3.43.4-3.1-2.7
Social response proportion0.50.71.20.7-0.80.61.1
Social responses0.60.81.60.9-1.30.80.6
Social time0.50.80.90.9-0.80.90.9
Soleus weight4.212.216.8-3.42.6-3.7-4.1
Bone: stiffness0.71.23.30.7-0.50.91.8
Tibialis anterior weight8.930.839.36.0-6.35.83.8
Time to tail flick, vehicle, before self-admin0.30.41.20.1-0.40.51.1
Time to tail flick, vehicle, after self-admin0.81.73.61.1-0.71.21.9
Time to tail flick, test, before self-admin0.60.71.3-1.11.1-0.50.1
Time to tail flick, test, after self-admin0.00.00.10.1-0.20.3-0.1
Delta time to tail flick, vehicle, before/after SA0.70.71.10.9-0.40.91.1
Delta time to tail flick, test, before/after SA1.01.32.41.3-1.50.9-0.3
Tibia length0.30.92.70.8-1.60.5-0.3
Ambulatory time before self-admin0.00.10.3-0.1-0.3-0.10.6
Ambulatory time after self-admin0.50.81.2-1.11.0-0.9-0.4
Bone: tissue strength0.10.10.2-0.50.2-0.4-0.1
Total heroin consumption4.04.75.72.4-1.82.32.1
Bone: trabecular number0.61.13.60.40.20.81.9
Bone: trabecular spacing0.30.41.2-0.40.3-0.5-1.1
Bone: trabecular thickness0.30.50.8-0.80.9-0.60.3
Bone: trabecular tissue density4.98.512.6-2.91.9-3.1-3.6
Water consumed over 24 hours0.51.01.71.0-0.61.11.3
Number of responses in last shaping day0.10.10.10.40.20.30.1