Best TWAS P = 1.85e-08 · Best GWAS P= 2.43e-08 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Ndufc1 | alternative TSS | NM_001399603.1 | 0.09 | 1 | 0.04 | 9.1e-06 | -5.34 | 9.53e-08 | 0.66 | FALSE |
| Adipose | Ndufc1 | alternative TSS | XM_063282586.1 | 0.09 | 1 | 0.04 | 8.5e-06 | 5.34 | 9.53e-08 | 0.64 | FALSE |
| Adipose | Ndufc1 | intron excision ratio | chr2_137598220_137600156 | 0.07 | 1 | 0.06 | 2.1e-07 | 5.32 | 1.05e-07 | 0.76 | FALSE |
| Adipose | Ndufc1 | intron excision ratio | chr2_137599544_137600156 | 0.05 | 1 | 0.03 | 4.9e-04 | -5.32 | 1.05e-07 | 0.11 | FALSE |
| BLA | Ndufc1 | intron excision ratio | chr2_137598220_137599505 | 0.14 | 2 | 0.11 | 3.3e-06 | -5.43 | 5.68e-08 | 0.68 | FALSE |
| BLA | Ndufc1 | intron excision ratio | chr2_137598220_137600156 | 0.19 | 13 | 0.19 | 3.6e-10 | 5.34 | 9.22e-08 | 0.69 | FALSE |
| Brain | Rab33b | gene expression | Rab33b | 0.08 | 14 | 0.11 | 8.0e-11 | 5.54 | 2.94e-08 | 0.69 | FALSE |
| Brain | Ndufc1 | intron excision ratio | chr2_137598220_137599505 | 0.08 | 1 | 0.08 | 2.9e-08 | -5.58 | 2.43e-08 | 0.93 | FALSE |
| IC | Ndufc1 | gene expression | Ndufc1 | 0.32 | 1 | 0.27 | 1.5e-11 | 5.38 | 7.61e-08 | 0.81 | FALSE |
| IL | Ndufc1 | isoform ratio | XR_351688.4 | 0.2 | 1 | 0.11 | 1.6e-03 | -5.24 | 1.61e-07 | 0.05 | FALSE |
| LHb | Noct | gene expression | Noct | 0.17 | 1 | 0.09 | 3.9e-03 | 5.24 | 1.61e-07 | 0.06 | FALSE |
| Liver | LOC134485908 | gene expression | LOC134485908 | 0.03 | 1 | 0.01 | 4.9e-02 | -5.49 | 3.98e-08 | 0.05 | TRUE |
| NAcc | Ndufc1 | isoform ratio | NM_001399603.1 | 0.23 | 48 | 0.26 | 5.3e-39 | 5.33 | 9.85e-08 | 0.65 | FALSE |
| NAcc | Ndufc1 | intron excision ratio | chr2_137598220_137599505 | 0.15 | 95 | 0.21 | 7.1e-32 | -5.26 | 1.45e-07 | 0.68 | TRUE |
| NAcc | Ndufc1 | intron excision ratio | chr2_137598220_137600156 | 0.24 | 64 | 0.29 | 4.4e-45 | 5.34 | 9.16e-08 | 0.68 | FALSE |
| NAcc | Ndufc1 | intron excision ratio | chr2_137599544_137600156 | 0.13 | 32 | 0.17 | 3.0e-24 | -5.26 | 1.42e-07 | 0.67 | FALSE |
| OFC | Ndufc1 | intron excision ratio | chr2_137599544_137600156 | 0.18 | 1981 | 0.06 | 1.6e-02 | -5.21 | 1.85e-07 | 0.46 | FALSE |
| PL | Ndufc1 | isoform ratio | NM_001399603.1 | 0.21 | 27 | 0.28 | 1.7e-30 | 5.63 | 1.85e-08 | 0.69 | TRUE |
| PL | Ndufc1 | isoform ratio | XR_351688.4 | 0.18 | 10 | 0.24 | 2.0e-25 | -5.51 | 3.49e-08 | 0.63 | FALSE |
| PL | Ndufc1 | intron excision ratio | chr2_137598220_137600156 | 0.33 | 17 | 0.38 | 4.5e-43 | 5.62 | 1.93e-08 | 0.72 | FALSE |
| PL | Ndufc1 | intron excision ratio | chr2_137599544_137600156 | 0.21 | 36 | 0.24 | 1.0e-25 | -5.56 | 2.77e-08 | 0.72 | FALSE |
| pVTA | Ndufc1 | gene expression | Ndufc1 | 0.17 | 1 | 0.2 | 6.5e-16 | 5.41 | 6.47e-08 | 0.84 | FALSE |
| pVTA | Ndufc1 | isoform ratio | NM_001399603.1 | 0.21 | 18 | 0.27 | 1.5e-21 | 5.42 | 5.82e-08 | 0.66 | TRUE |
| pVTA | Ndufc1 | isoform ratio | XR_351688.4 | 0.16 | 1 | 0.21 | 3.5e-17 | -5.33 | 9.62e-08 | 0.78 | FALSE |