Slc22a8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	isoform ratio	XM_008760243.3	0.03	0.02	5.1e-03	0.01	0.01	0.01	0.01	2.5e-02	2.4e-02	3.3e-02	2.2e-02
2	Brain	mRNA stability	Slc22a8	0.1	0.06	1.5e-06	0.02	0.06	0.04	0.06	1.1e-02	4.5e-06	4.5e-05	5.0e-06
3	PL	mRNA stability	Slc22a8	0.02	0.01	8.1e-03	0.02	0.02	0.02	0.02	2.5e-03	1.5e-03	2.9e-03	1.9e-03
4	Liver	mRNA stability	Slc22a8	0.16	0.07	5.0e-16	0.08	0.12	0.11	0.13	1.9e-09	1.5e-13	3.5e-12	6.8e-14
5	BLA	intron excision ratio	chr1_205498243_205498906	0.08	0.05	5.5e-03	0.04	0.04	0.02	0.03	4.7e-03	2.3e-03	3.5e-02	6.3e-03
6	Brain	gene expression	Slc22a8	0.13	0.06	1.8e-09	0.09	0.1	0.1	0.1	1.2e-08	1.3e-09	8.3e-10	1.1e-09
7	Liver	gene expression	Slc22a8	0.13	0.07	9.4e-10	0.02	0.05	0.05	0.04	1.5e-03	1.4e-06	2.9e-06	9.3e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.6	1.0	1.9	0.7	-1.0	-1.0	-1.4	-0.6	1.4	-0.4
Area under the delay curve	0.3	0.3	0.8	-0.1	0.4	-0.2	-0.4	0.1	0.9	-0.9
BMI with tail	2.9	9.5	17.8	2.8	-2.1	-3.5	-4.2	-0.4	4.2	-2.6
BMI without tail	1.1	2.2	3.7	1.4	-0.4	-1.7	-1.7	0.6	1.9	-1.9
Body weight	2.8	11.7	18.5	4.2	-2.0	-4.3	-4.2	1.6	3.6	-2.9
Weight adjusted by age	1.5	1.7	2.9	1.6	-1.6	-1.6	-1.7	-0.2	1.1	-0.1
Bone surface	2.2	3.9	6.9	1.9	-2.6	-2.2	-2.6	-1.0	2.0	0.0
Bone volume	1.5	2.6	5.1	1.3	-2.3	-1.6	-2.1	-1.4	1.6	0.4
Breakpoint value in progressive ratio session	1.0	1.1	2.5	1.6	-1.5	-1.3	-0.8	0.5	-0.2	0.5
Number of licking bursts	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.2	-0.1	0.1	0.0
Context. condit. distance diff. score	0.3	0.4	0.7	-0.8	0.8	0.4	0.2	-0.3	0.8	-0.8
Locomotion velocity, session 1	0.5	0.6	1.7	-0.4	1.1	-0.0	0.3	0.7	0.6	-1.3
Locomotion distance, session 1	0.9	1.1	2.7	0.7	0.2	-1.0	-1.0	0.5	1.6	-1.7
Locomotion velocity, session 2	1.8	2.1	3.4	1.8	-1.0	-1.8	-1.8	0.6	1.5	-1.0
Locomotion distance, session 2	0.3	0.4	1.3	0.4	0.5	-0.4	-0.3	0.8	0.6	-1.1
Locomotion velocity, session 3	1.3	1.5	4.7	0.5	-0.1	-1.0	-1.5	-0.3	2.2	-1.5
Locomotion distance, session 3	0.2	0.3	0.8	0.2	0.4	-0.2	-0.3	0.5	0.6	-0.9
Stereotopy head waving bouts, day 3	0.7	0.8	3.0	-0.7	-0.0	-0.1	-0.7	-1.1	1.7	-0.8
Stereotopy head waving duration, day 3	0.4	0.4	1.4	-0.7	0.4	0.1	-0.2	-0.7	1.2	-0.6
Locomotion velocity, session 7	0.2	0.2	0.7	-0.3	-0.2	-0.1	-0.4	-0.7	0.8	-0.2
Locomotion distance, session 7	0.4	0.5	1.5	-0.5	0.8	0.1	-0.0	0.1	0.9	-1.2
Stereotopy head waving bouts, day 7	0.6	0.6	1.5	0.1	-1.2	-0.4	-0.7	-1.1	0.6	0.7
Stereotopy head waving duration, day 7	1.4	1.7	2.7	1.5	-1.6	-1.6	-1.6	-0.1	1.2	-0.1
Locomotion velocity, session 8	0.5	0.7	1.9	-0.3	1.4	0.4	0.7	1.0	-0.1	-0.9
Locomotion distance, session 8	0.3	0.4	1.3	-0.6	0.4	0.2	-0.3	-0.7	1.1	-0.7
Degree of sensitization distance	0.5	0.5	1.8	-0.4	-0.1	-0.2	-0.7	-0.8	1.3	-0.7
Degree of sensitization stereotypy	1.0	1.1	2.7	1.1	-1.7	-1.0	-1.2	-0.6	0.5	0.7
Conditioned locomotion	0.3	0.4	0.7	0.7	-0.4	-0.8	-0.6	0.5	0.7	-0.6
Cocaine response after cond. corrected	1.0	1.1	3.1	-1.2	1.8	0.9	1.0	0.5	0.2	-1.1
Cocaine response after cond. not corrected	0.6	0.6	1.7	-0.9	1.3	0.7	0.8	0.3	0.1	-0.8
Cocaine response before conditioning	0.5	0.6	1.7	0.8	-1.3	-0.6	-0.6	-0.4	-0.3	1.0
Saline control response	1.5	2.0	3.7	1.9	-0.3	-1.7	-1.3	1.6	1.1	-1.4
Bone: connectivity density	1.7	2.7	4.9	1.7	-1.5	-2.0	-2.2	-0.1	2.0	-0.9
Bone: cortical apparent density	0.2	0.2	0.9	0.6	-0.1	-0.5	0.2	0.9	-0.4	-0.1
Bone: cortical area	0.9	1.3	2.3	1.2	-1.5	-1.3	-1.5	-0.4	1.0	0.1
Bone: cortical porosity	0.2	0.2	0.8	-0.2	0.0	0.4	0.6	0.1	-0.9	0.6
Bone: cortical porosity	0.2	0.2	0.6	0.1	0.1	0.2	0.5	0.5	-0.8	0.3
Bone: cortical thickness	1.4	2.4	5.6	2.4	-0.4	-1.8	-1.0	2.3	0.3	-1.2
Bone: cortical thickness	0.6	0.7	2.6	0.7	0.6	-0.5	0.1	1.6	-0.1	-1.1
Bone: cortical tissue density	0.2	0.3	1.1	0.7	-0.2	-0.5	0.1	1.0	-0.5	-0.1
Condit. Reinf. active minus inactive responses	0.6	0.7	1.4	1.2	-0.8	-1.1	-1.0	0.3	0.6	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.5	0.6	-0.1	-0.5	-0.1	0.7	-0.1	-0.2
Condit. Reinf. active responses	1.1	1.3	2.4	1.2	-1.6	-1.3	-1.5	-0.5	1.0	0.1
Condit. Reinf. inactive responses	0.8	0.9	2.2	0.2	-1.4	-0.4	-1.1	-1.5	0.6	0.7
Incentive salience index mean	1.2	1.4	2.5	1.4	-1.0	-1.5	-1.6	0.1	1.3	-0.7
Condit. Reinf. lever presses	1.0	1.4	2.7	1.3	-0.9	-1.3	-1.7	-0.2	1.5	-0.7
Condit. Reinf. active minus inactive responses	0.6	0.8	2.4	-0.5	-0.8	0.6	0.3	-1.2	-0.7	1.5
Condit. Reinf. active-inactive response ratio	1.8	1.9	5.9	-0.8	-1.5	0.6	-0.2	-2.4	-0.2	2.1
Condit. Reinf. active responses	0.0	0.1	0.2	0.1	-0.3	0.0	-0.1	-0.2	-0.2	0.5
Condit. Reinf. inactive responses	0.7	0.9	2.9	0.5	1.2	-0.2	0.3	1.7	-0.1	-1.3
Condit. Reinf. lever presses	0.8	1.1	2.1	1.3	-1.5	-1.2	-1.4	-0.3	0.6	0.2
Condit. Reinf. lever reinforcers received	0.1	0.2	0.4	0.4	-0.7	-0.3	-0.3	-0.1	-0.2	0.6
Conditioned reinforcement - actives	2.2	2.2	4.4	-1.5	-0.4	1.5	1.1	-1.8	-1.3	2.1
Conditioned reinforcement - inactives	1.0	1.2	4.0	-1.0	-0.8	0.7	0.1	-2.0	-0.0	1.4
Conditioned locomotion	1.2	1.4	3.6	-1.8	0.3	1.3	0.7	-1.9	-0.1	0.8
Patch foraging indifference point 0 sec	0.3	0.5	1.0	0.7	-0.5	-1.0	-0.8	0.3	0.9	-0.6
Patch foraging indifference point AUC	1.9	2.2	5.5	1.9	-2.3	-1.6	-1.5	-0.3	0.2	1.0
Delay disc. indifference point, 0s delay	0.6	0.7	1.9	-0.6	1.1	0.2	-0.2	-0.1	1.2	-1.4
Delay disc. indifference point, 16s delay	0.4	0.4	0.8	0.3	-0.7	-0.6	-0.9	-0.6	0.9	-0.1
Delay disc. indifference point, 2s delay	0.2	0.2	0.6	-0.5	0.1	0.2	-0.2	-0.8	0.6	-0.2
Delay disc. indifference point, 24s delay	0.4	0.4	1.3	0.1	0.7	-0.3	-0.1	0.8	0.5	-1.2
Delay disc. indifference point, 4s delay	1.0	1.0	3.4	0.3	0.8	-0.6	-0.5	0.9	1.3	-1.8
Delay disc. indifference point, 8s delay	0.6	0.6	1.8	-0.7	1.3	0.6	0.7	0.5	0.1	-0.9
Indifference point function ln k	3.3	4.7	12.7	-2.7	3.6	2.0	2.1	0.6	0.1	-2.0
Indifference point function log k	3.3	4.7	12.7	-2.7	3.6	2.0	2.1	0.6	0.1	-2.0
Patch foraging total patch changes 0 sec	0.3	0.5	0.9	0.7	-0.1	-0.9	-0.5	0.9	0.7	-1.0
Patch foraging total patch changes 12 sec	3.2	4.2	8.3	2.9	-2.5	-2.8	-2.2	1.0	1.1	-0.3
Patch foraging total patch changes 18 sec	0.3	0.4	1.2	0.9	-1.1	-0.7	-0.6	0.0	-0.1	0.5
Patch foraging total patch changes 24 sec	4.7	5.8	10.2	3.1	-2.0	-3.2	-2.9	1.1	2.3	-1.4
Patch foraging total patch changes 6 sec	0.8	1.2	2.0	1.2	-0.8	-1.4	-1.3	0.6	1.2	-1.0
Patch foraging time to switch 0 sec	0.9	1.4	2.7	0.6	-1.6	-1.1	-1.5	-1.2	1.3	0.2
Patch foraging water rate 0 sec	0.5	0.8	1.5	-0.9	1.2	0.9	1.2	0.6	-0.7	-0.2
Patch foraging water rate 12 sec	2.1	3.2	8.8	-1.7	3.0	1.7	2.1	1.2	-0.8	-1.2
Patch foraging water rate 18 sec	1.4	2.0	5.8	-0.9	2.4	0.7	0.8	1.1	0.4	-2.1
Patch foraging water rate 24 sec	1.1	1.5	3.8	-1.4	1.9	1.4	1.4	0.5	-0.6	-0.6
Patch foraging water rate 6 sec	1.5	2.2	6.7	-1.2	2.6	1.4	1.5	1.1	-0.6	-1.2
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.2	0.1	-0.2	-0.3	0.2	0.4	-0.4
Distance traveled before self-admin	1.7	1.8	3.6	1.7	-1.9	-1.7	-1.6	-0.1	0.8	0.3
Distance traveled after self-admin	0.3	0.3	0.8	0.7	-0.9	-0.5	-0.4	0.0	-0.2	0.6
Extensor digitorum longus weight	4.4	17.5	30.1	5.5	-3.1	-5.5	-5.0	2.1	3.9	-2.9
Bone: elastic displacement	0.9	1.1	2.1	-0.8	1.5	1.0	1.3	1.0	-1.0	-0.3
Bone: elastic work	0.8	1.1	2.9	0.9	0.6	-0.8	-0.3	1.7	0.5	-1.5
Bone: endosteal estimation	1.0	2.2	8.8	-1.6	-0.7	0.6	-0.8	-3.0	1.5	0.5
Bone: endosteal perimeter	1.7	3.5	14.5	-1.8	-1.3	1.0	-0.6	-3.8	1.1	1.6
Epididymis fat weight	0.2	0.5	1.6	-0.5	0.1	0.3	-0.5	-1.3	0.9	-0.2
Delta time in closed arm before/after self-admin	2.7	2.6	7.9	1.0	1.2	-1.2	-0.8	1.9	1.5	-2.8
Delta time in open arm before/after self-admin	1.5	1.5	4.3	1.3	-2.1	-1.2	-1.2	-0.6	0.4	1.0
Diff in mean of infusions in LGA sessions	0.7	0.8	1.9	1.4	-0.7	-1.1	-0.4	1.3	-0.3	-0.1
Delay discount exponential model param	0.2	0.2	0.8	0.1	-0.4	0.2	0.3	-0.1	-0.8	0.9
Extinction: sum of active levers before priming	2.3	2.3	4.4	2.1	-1.7	-2.1	-1.7	0.7	1.0	-0.4
Active lever presses in extinction session 6	1.6	1.5	3.9	1.7	-2.0	-1.5	-1.1	0.2	0.1	0.7
Bone: final force	1.8	2.9	5.2	1.9	-1.8	-2.1	-2.3	-0.1	1.9	-0.7
Bone: final moment	1.8	2.9	5.1	1.9	-1.8	-2.1	-2.3	-0.1	1.9	-0.7
Food consumed during 24 hour testing period	0.1	0.2	0.6	-0.1	-0.4	0.2	-0.0	-0.5	-0.4	0.8
Glucose	1.1	1.7	4.0	-2.0	0.6	1.7	0.7	-1.9	-0.1	0.7
Heart weight	0.6	0.9	2.2	-1.4	1.5	0.9	0.7	-0.2	0.4	-0.9
Delay discount hyperbolic model param	0.3	0.3	0.8	0.0	-0.4	0.3	0.4	-0.1	-0.9	0.9
Intermittent access intake day 1-15 change	2.1	2.1	5.4	-0.9	-0.5	1.3	1.2	-1.2	-1.9	2.3
Intermittent access intake escalation	1.4	1.4	3.9	-0.6	-0.6	1.0	0.9	-1.0	-1.6	2.0
Intermittent access intake escalation 2	0.9	0.8	2.9	0.1	-1.1	0.2	0.3	-0.8	-1.0	1.7
Intermitt. access day 1 inactive lever presses	1.1	1.2	2.3	-1.5	0.4	1.4	0.9	-1.4	-0.4	1.0
Intermitt. access day 15 inactive lever presses	1.0	1.1	2.4	0.4	-1.4	-0.6	-1.2	-1.6	1.1	0.6
Intermitt. access escalation Index	0.5	0.5	1.4	-0.3	1.1	0.2	0.1	0.4	0.5	-1.2
Intermittent access day 1 total infusions	1.2	1.4	4.9	-1.1	-0.2	0.3	-0.8	-2.2	1.6	-0.4
Intermittent access day 15 total infusions	2.2	2.5	7.6	-1.9	-0.3	1.6	0.6	-2.8	-0.4	1.7
Intermittent access terminal intake (last 3 days)	1.6	1.8	7.3	-0.8	-1.4	0.3	-0.6	-2.7	0.7	1.2
Intermittent access total infusions	1.2	1.3	5.9	-1.0	-0.8	0.5	-0.5	-2.4	0.7	0.8
Intermittent access day 1 locomotion	1.4	1.5	4.5	-0.5	0.0	-0.3	-1.2	-1.4	2.1	-1.3
Intermittent access day 15 total locomotion	0.8	0.8	3.5	-0.5	-0.9	-0.1	-0.7	-1.9	0.8	0.4
Intermittent access total locomotion	2.2	2.5	8.0	-0.4	-1.5	-0.5	-1.6	-2.8	2.0	0.1
Intermittent access standard deviation	1.6	1.7	3.2	-1.2	-0.1	1.4	1.4	-1.0	-1.6	1.8
Left kidney weight	0.2	0.4	0.7	0.3	-0.8	-0.4	-0.8	-0.9	0.7	0.2
Right kidney weight	0.4	1.2	2.5	0.8	-1.6	-0.8	-1.4	-1.3	0.9	0.6
Cocaine induced anxiety	0.3	0.4	1.2	0.5	-1.1	-0.6	-0.6	-0.5	0.3	0.5
Post-drug Anxiety	0.6	0.7	2.2	0.8	-1.5	-0.8	-0.6	-0.4	0.2	0.9
Baseline Anxiety	0.6	0.6	1.3	1.1	-0.1	-0.9	-0.5	1.2	0.4	-0.6
Tail length	0.5	1.5	5.1	1.7	0.2	-1.2	-0.3	2.3	-0.0	-1.1
Length with tail	1.3	4.7	9.7	3.1	-1.3	-2.9	-2.2	2.0	1.5	-1.6
Length without tail	1.4	3.1	5.8	2.4	-1.4	-2.2	-2.2	0.8	1.5	-1.0
Times rat made contact with spout	0.4	0.4	1.6	0.3	0.8	-0.1	0.3	1.3	-0.1	-0.7
Lifetime Intake	0.7	0.8	3.4	-1.0	-0.1	0.6	-0.3	-1.8	0.7	0.2
Liver weight, left	0.2	0.4	0.6	-0.8	0.8	0.7	0.7	0.2	-0.5	-0.2
Liver weight, right	0.3	0.4	1.4	0.2	0.3	-0.3	-0.6	0.2	1.0	-1.2
Locomotor activity	1.4	2.2	5.9	-1.3	2.4	1.3	1.7	1.3	-0.8	-1.1
Locomotor testing distance	1.7	2.8	8.4	-1.2	2.9	1.3	1.5	1.6	-0.3	-1.8
Locomotor testing rearing	1.0	1.6	4.7	-1.2	2.2	1.3	1.2	0.8	-0.5	-0.9
Locomotion in novel chamber	1.6	2.0	6.3	-1.4	-0.7	1.2	0.4	-2.5	-0.5	1.8
Locomotion in novel chamber post-restriction	1.7	2.0	3.5	-1.9	0.8	1.9	1.5	-1.2	-1.2	1.2
Fecal boli incidents, locomotor time 1	1.1	1.2	3.3	-0.4	-1.3	0.4	-0.1	-1.6	-0.6	1.8
Change in fecal boli incidents, locomotor task	1.3	1.2	3.8	-0.9	1.9	0.7	0.8	0.7	0.4	-1.5
Time >=10cm from walls, locomotor time 1	2.0	2.0	6.9	-1.4	-0.8	1.1	0.2	-2.6	-0.3	1.8
Bouts of movement, locomotor time 1	0.9	0.9	3.0	0.5	-0.3	0.3	0.8	0.9	-1.7	1.3
Total resting periods, locomotor time 1	0.6	0.7	1.9	0.5	-0.6	0.1	0.5	0.5	-1.4	1.4
Rest time, locomotor task time 1	1.1	1.2	1.9	-1.3	0.7	1.4	1.4	-0.3	-1.2	0.9
Distance moved, locomotor task time 1	0.3	0.3	0.5	0.5	-0.3	-0.7	-0.7	-0.0	0.7	-0.5
Vertical activity count, locomotor time 1	0.3	0.3	0.8	-0.9	0.6	0.8	0.6	-0.4	-0.3	0.1
Time >=10cm from walls, locomotor time 2	0.7	0.8	2.5	-0.2	-0.9	0.4	0.3	-0.9	-0.9	1.6
Bouts of movement, locomotor time 2	0.7	0.7	1.9	1.4	-0.6	-1.1	-0.8	0.9	0.3	-0.3
Total resting periods, locomotor time 2	0.3	0.4	1.0	1.0	-0.5	-0.8	-0.5	0.6	0.2	-0.1
Rest time, locomotor task time 2	1.8	2.1	4.2	-2.1	1.2	2.0	1.6	-1.0	-1.0	0.8
Distance moved, locomotor task time 2	0.2	0.3	0.6	0.8	-0.4	-0.5	-0.0	0.7	-0.5	0.2
Vertical activity count, locomotor time 2	0.7	0.8	1.9	-0.2	1.1	0.5	1.0	1.4	-0.9	-0.4
Light reinforcement 1	0.2	0.3	0.9	-0.1	0.5	0.6	0.6	0.3	-0.9	0.4
Light reinforcement 2	1.5	2.0	5.4	0.1	-1.9	0.1	-0.8	-2.3	-0.1	2.0
Bone: marrow area	1.0	2.2	8.8	-1.7	-0.6	0.7	-0.6	-3.0	1.5	0.5
Bone: maximum diameter	0.8	1.4	3.1	0.5	-1.8	-0.7	-1.4	-1.6	1.0	0.8
Bone: maximum force	3.3	5.7	10.8	2.2	-2.7	-2.7	-3.3	-1.0	2.9	-0.7
Bone: maximum moment	3.1	5.3	10.0	2.2	-2.5	-2.7	-3.2	-0.9	2.7	-0.7
Mean time between licks in bursts	1.5	2.1	5.7	0.8	1.4	-0.8	-0.1	2.2	0.8	-2.4
Mean num. licks in bursts	0.2	0.3	0.6	-0.3	0.7	0.3	0.7	0.7	-0.4	-0.3
Cd content in liver	1.0	1.0	1.9	-1.4	0.2	1.2	1.0	-1.2	-0.7	1.2
Co content in liver	3.5	4.1	7.5	-1.6	2.7	2.0	2.7	1.5	-2.2	-0.2
Cu content in liver	0.3	0.4	1.1	0.4	0.7	-0.3	0.1	1.1	0.1	-0.8
Fe content in liver	0.1	0.1	0.3	-0.1	-0.4	0.1	-0.0	-0.6	0.0	0.5
K content in liver	1.6	1.6	3.2	1.2	-1.3	-1.4	-1.8	-0.5	1.6	-0.5
Mg content in liver	1.2	1.2	3.0	0.7	-0.9	-1.0	-1.6	-0.7	1.7	-0.6
Mn content in liver	1.6	1.9	3.5	1.9	-1.7	-1.7	-1.7	0.0	1.0	0.0
Na content in liver	0.7	0.8	1.7	0.8	-1.3	-0.9	-1.1	-0.5	0.7	0.3
Rb content in liver	0.7	0.9	2.0	-1.3	1.4	1.2	0.8	-0.4	0.1	-0.4
Se content in liver	1.2	1.5	3.9	0.6	-2.0	-0.7	-1.2	-1.5	0.5	1.3
Sr content in liver	2.8	2.6	6.2	2.5	-1.7	-2.2	-1.7	0.9	0.8	-0.3
Zn content in liver	2.7	2.9	5.2	2.1	-2.0	-2.3	-2.1	0.3	1.4	-0.5
Bone: minimum diameter	1.0	1.8	6.7	-0.9	-1.1	0.1	-1.1	-2.6	1.6	0.5
Time in familiar zone, hab. session 1	0.2	0.2	0.4	0.4	-0.2	-0.5	-0.6	0.1	0.6	-0.5
Time in novel zone, hab. session 1	1.2	1.2	2.1	-1.3	1.4	1.3	1.4	0.2	-0.9	0.1
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.4	-0.1	-0.5	-0.2	0.4	0.2	-0.3
Total locomotion distance, hab. session 1	0.2	0.3	1.0	-0.4	-0.5	-0.0	-0.4	-1.0	0.6	0.1
Locomotion velocity, hab. session 1	0.2	0.3	0.5	0.2	-0.7	-0.5	-0.6	-0.6	0.6	0.0
Time in familiar zone, hab. session 2	0.8	0.8	1.7	-0.2	1.3	0.7	1.0	1.2	-1.0	-0.5
Time in novel zone, hab. session 2	0.7	0.7	1.7	0.4	-0.8	-0.9	-1.1	-0.6	1.3	-0.3
Total zone transitions, hab. session 2	1.5	1.9	2.8	1.5	-0.3	-1.6	-1.5	0.9	1.7	-1.7
Total locomotion distance, hab. session 2	0.4	0.5	1.4	0.4	-0.1	-0.6	-0.9	0.0	1.2	-1.0
Locomotion velocity, hab. session 2	0.3	0.4	1.3	0.2	-0.2	-0.5	-0.9	-0.4	1.1	-0.7
Novel to familiar place preference ratio	1.6	1.7	2.9	1.5	-1.7	-1.6	-1.7	-0.3	1.0	0.1
Novelty place preference	1.1	1.1	2.2	1.2	-1.5	-1.2	-1.3	-0.4	0.8	0.3
Time in novel zone, NPP test	1.1	1.1	1.9	1.2	-1.4	-1.3	-1.4	-0.3	0.9	0.1
Total zone transitions, NPP test	0.7	1.1	1.6	1.2	-0.3	-1.3	-1.0	0.9	1.1	-1.2
Total locomotion distance, NPP test	0.2	0.3	0.9	0.1	0.3	-0.3	-0.4	0.2	0.8	-1.0
Locomotion velocity, NPP test	0.1	0.1	0.4	-0.0	0.3	-0.1	-0.1	0.2	0.5	-0.6
Intraocular pressure	0.3	0.5	1.4	-0.2	-0.1	0.5	0.6	-0.2	-1.0	1.2
Delta distance traveled before/after self-admin	0.6	0.7	1.5	-0.8	1.2	0.9	1.0	0.5	-0.6	-0.2
Delta ambulatory time before/after self-admin	1.1	1.2	2.6	-1.1	1.6	1.2	1.3	0.6	-0.9	-0.3
Parametrial fat weight	0.7	1.4	4.8	-1.7	-0.1	1.1	0.3	-2.2	0.3	0.7
Pavlov. Cond. lever latency	1.4	1.7	3.3	-1.4	1.4	1.6	1.8	0.4	-1.5	0.6
Pavlov. Cond. magazine entry latency	1.5	1.9	3.9	1.4	-2.0	-1.5	-1.9	-0.8	1.1	0.2
Pavlov. Cond. change in total contacts	1.2	1.3	3.6	0.6	-1.9	-0.7	-1.1	-1.4	0.5	1.1
Pavlov. Cond. index score	0.7	0.9	2.2	1.0	-1.5	-1.0	-1.2	-0.5	0.5	0.4
Pavlov. Cond. latency score	0.6	0.8	1.4	0.9	-1.2	-1.0	-1.2	-0.4	0.8	-0.0
Pavlov. Cond. lever contacts	0.4	0.5	1.0	0.7	-0.8	-0.8	-1.0	-0.3	0.8	-0.3
Pavlov. Cond. magazine entry number	0.8	1.0	2.9	-1.0	1.7	0.9	0.9	0.5	0.0	-0.9
Pavlov. Cond. intertrial magazine entries	0.4	0.4	1.5	0.1	-0.7	0.1	0.3	-0.3	-0.9	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	2.9	1.2	-1.7	-1.1	-1.3	-0.6	0.6	0.4
Pavlov. Cond. response bias	0.9	1.1	2.7	1.1	-1.7	-1.1	-1.3	-0.5	0.5	0.5
Pavlov. Cond. lever latency	0.6	0.8	1.5	-0.9	1.0	1.0	1.2	0.4	-0.9	0.1
Pavlov. Cond. magazine entry latency	2.3	2.6	5.7	2.4	-1.8	-2.2	-1.8	0.9	0.7	-0.3
Pavlov. Cond. change in total contacts	1.5	2.0	5.2	1.6	-2.3	-1.5	-1.7	-0.6	0.5	0.9
Pavlov. Cond. index score	2.0	2.5	4.9	2.0	-2.2	-2.0	-2.0	-0.1	0.9	0.2
Pavlov. Cond. latency score	1.9	2.4	4.7	1.9	-2.2	-1.9	-2.0	-0.3	0.9	0.2
Pavlov. Cond. lever contacts	0.3	0.4	0.8	0.8	-0.9	-0.7	-0.7	-0.0	0.0	0.3
Pavlov. Cond. magazine entry number	4.1	5.0	10.1	-3.2	2.7	3.0	2.6	-0.7	-1.2	0.3
Pavlov. Cond. intertrial magazine entries	1.2	1.5	2.7	-1.5	0.8	1.6	1.4	-0.8	-1.2	1.1
Pavlov. Cond. lever-magazine prob. diff.	2.1	2.7	4.8	2.2	-2.2	-2.1	-2.0	0.0	0.9	0.1
Pavlov. Cond. response bias	1.0	1.4	2.7	1.7	-1.5	-1.5	-1.4	0.2	0.5	0.1
Time in closed arm before self-admin	0.5	0.6	1.3	0.1	-1.1	-0.1	-0.4	-1.1	-0.1	1.1
Time in closed arm after self-admin	0.4	0.4	1.0	-0.8	1.0	0.6	0.5	0.1	0.0	-0.6
Time in open arm before self-admin	2.5	2.7	7.9	-1.1	2.8	1.1	1.5	1.7	-0.5	-1.7
Time in open arm after self-admin	0.2	0.3	0.8	0.1	0.5	0.2	0.6	0.9	-0.7	0.0
Bone: periosteal estimation	1.0	2.0	5.3	-0.1	-1.7	-0.6	-1.6	-2.3	1.7	0.5
Bone: periosteal perimeter	0.7	1.2	3.2	0.1	-1.5	-0.3	-1.1	-1.8	0.9	0.9
Bone: post-yield work	2.4	3.3	10.4	-0.5	-2.2	-0.5	-1.8	-3.2	1.8	1.0
Progressive ratio test 1 active lever presses	1.4	1.5	3.1	-1.8	0.5	1.5	1.2	-1.3	-0.8	1.0
Progressive ratio test 1 breakpoint	1.7	1.7	3.4	-1.9	0.5	1.6	1.3	-1.3	-0.9	1.2
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.7	-0.0	0.4	-0.3	-0.4	0.1	0.8	-0.9
Progressive ratio test 2 active lever presses	1.4	1.5	4.7	-1.5	-0.4	1.1	0.5	-2.2	-0.3	1.3
Progressive ratio test 2 breakpoint	2.0	2.3	4.7	-1.9	-0.1	1.6	1.1	-2.2	-0.9	1.7
Progressive ratio test 2 inactive lever presses	1.0	1.1	4.7	-1.0	-0.8	0.5	-0.3	-2.2	0.5	1.0
Incentive Sensitization - Responses	0.6	0.6	1.3	0.2	-1.2	-0.5	-0.9	-1.1	0.7	0.5
Incentive Sensitization - Breakpoint	0.6	0.7	1.7	0.1	-1.2	-0.4	-0.8	-1.3	0.6	0.6
Sum of active levers in priming session hrs 5-6	1.9	1.8	5.3	1.2	-2.3	-0.8	-0.5	-0.6	-0.8	2.1
Progressive ratio	0.3	0.4	0.7	0.4	-0.8	-0.4	-0.9	-0.8	0.5	0.3
Food seeking constrained by brief footshock	0.3	0.3	1.0	-0.3	1.0	0.3	0.4	0.7	-0.0	-0.7
Seeking ratio, punishment vs. effort	0.8	1.0	2.6	-0.6	1.6	0.5	1.0	1.3	-0.2	-1.1
Retroperitoneal fat weight	1.0	3.2	8.5	-2.9	1.5	2.3	1.3	-2.2	0.1	0.3
Reaction time number correct	0.5	0.7	1.9	1.0	0.3	-0.8	-0.4	1.4	0.5	-1.0
Reaction time mean minus median	1.2	1.6	4.3	0.6	-2.1	-0.4	-0.3	-0.9	-0.9	2.1
Reaction time mean minus median AUC	0.6	0.8	2.4	0.4	-1.0	0.0	0.4	-0.1	-1.4	1.6
Reaction time num false alarms	1.4	2.0	4.9	-0.8	2.2	0.8	1.5	1.7	-0.7	-1.3
Reaction time num false alarms AUC	1.4	1.9	4.6	-0.4	2.0	0.4	1.2	2.1	-0.6	-1.6
Reaction time trials correct on left	0.5	0.7	1.9	1.0	0.3	-0.8	-0.4	1.4	0.5	-1.0
Reaction time trials on left	0.5	0.7	2.0	1.0	0.3	-0.8	-0.4	1.4	0.5	-0.9
Reaction time mean	0.7	0.9	3.0	-0.2	-1.1	0.3	0.3	-0.9	-1.2	1.7
Reaction time mean AUC	0.7	1.0	3.1	-0.2	-1.0	0.4	0.3	-1.0	-1.2	1.8
Median of all reaction times	0.3	0.4	1.1	-0.1	-0.9	-0.0	0.1	-0.7	-0.5	1.0
Reaction time omissions	0.3	0.5	1.5	-0.0	0.0	0.2	0.9	0.7	-1.2	0.6
Reaction time false alarm rate	0.8	1.1	2.6	-0.9	1.6	0.7	1.2	1.0	-0.6	-0.9
Reaction time premature initiation rate	3.6	4.8	7.7	2.6	-0.1	-2.5	-2.1	2.1	2.0	-2.8
Reaction time premature initiations	4.1	5.8	9.3	3.1	0.0	-2.7	-2.0	2.9	1.8	-2.9
Std. dev. reaction times	1.1	1.5	4.6	-0.2	-1.0	0.6	0.8	-0.7	-1.8	2.1
Reaction time trials completed	0.5	0.7	2.0	1.0	0.3	-0.8	-0.4	1.4	0.5	-0.9
Reaction time trials AUC	0.5	0.7	1.8	0.9	0.4	-0.7	-0.3	1.3	0.5	-1.0
Run reversals in cocaine runway, females	2.4	2.3	7.0	0.8	0.8	-1.2	-1.3	1.0	2.0	-2.6
Run reversals in cocaine runway, males	0.5	0.5	0.9	-0.8	0.7	0.9	0.9	0.1	-0.7	0.3
Latency to leave start box in cocaine runway	0.3	0.3	1.1	-0.6	-0.1	0.2	-0.2	-1.1	0.6	-0.1
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.0	-0.3	-0.2	-0.3	-0.4	0.4	0.0
Latency to leave start box in cocaine runway, M	1.5	1.5	3.5	-1.9	0.9	1.6	1.2	-1.2	-0.6	0.5
Std. dev. time between licks in bursts	0.9	1.1	2.9	-0.5	1.7	0.4	0.8	1.3	-0.1	-1.4
Total sessions with >9 infusions	0.7	0.7	1.6	-1.3	0.9	1.0	0.3	-1.2	0.3	-0.4
Short access day 1 total inactive lever presses	0.4	0.5	1.1	-1.1	0.7	0.7	0.1	-0.9	0.6	-0.4
Short access day 10 total inactive lever presses	1.7	1.8	4.0	-1.8	2.0	1.7	1.5	-0.0	-0.6	-0.4
Short access day 1 total infusions	0.4	0.5	0.9	-0.9	0.8	0.7	0.0	-0.8	0.5	-0.5
Short access day 10 total infusions	0.8	0.9	2.4	-0.5	-0.0	-0.1	-1.0	-1.5	1.6	-0.7
Short access total infusions	0.5	0.5	1.1	-0.7	0.7	0.3	-0.4	-0.9	1.0	-0.8
Short access day 1 locomotion	1.0	1.1	3.1	0.2	-0.1	-0.7	-1.3	-0.7	1.8	-1.3
Short access day 10 total locomotion	0.6	0.7	1.9	0.1	-0.4	-0.5	-1.1	-1.0	1.4	-0.8
Short access total locomotion	1.3	1.4	3.6	0.4	-0.3	-0.9	-1.5	-0.8	1.9	-1.4
One hour access (0.3 mA shock)	2.1	2.5	6.0	-2.1	0.3	1.9	0.9	-2.4	-0.5	1.3
Compulsive drug intake	2.3	2.3	8.3	1.2	1.4	-0.7	-0.1	2.9	0.1	-2.0
One hour access (shock baseline)	4.3	5.0	12.1	-2.5	-0.6	2.2	1.3	-3.5	-1.2	2.8
Social response proportion	0.1	0.1	0.2	0.4	0.1	-0.4	-0.3	0.4	0.2	-0.5
Social responses	0.2	0.3	1.2	0.2	0.5	0.0	0.5	1.1	-0.6	-0.3
Social time	0.3	0.4	1.1	0.1	0.9	0.3	0.7	1.0	-0.7	-0.3
Soleus weight	1.4	4.0	9.0	-3.0	2.0	2.8	2.2	-1.2	-1.1	0.7
Bone: stiffness	1.2	1.9	4.0	1.2	-2.0	-1.4	-1.8	-1.0	1.2	0.4
Tibialis anterior weight	5.6	19.1	38.4	6.2	-3.9	-5.9	-5.0	2.4	3.2	-2.1
Time to tail flick, vehicle, before self-admin	1.2	1.3	2.4	0.7	-1.2	-1.1	-1.5	-1.0	1.6	-0.3
Time to tail flick, vehicle, after self-admin	0.8	0.8	2.2	0.5	0.2	-0.8	-0.8	0.5	1.2	-1.5
Time to tail flick, test, before self-admin	1.5	1.5	3.9	0.5	0.2	-0.9	-1.3	0.0	2.0	-1.9
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.3	0.2	0.3	0.3	-0.0	-0.3	0.2
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.6	-0.1	0.7	0.0	0.3	0.7	0.0	-0.8
Delta time to tail flick, test, before/after SA	1.2	1.0	3.1	-0.1	-0.3	0.6	1.1	0.2	-1.8	1.6
Tibia length	1.6	4.6	12.0	2.1	-3.5	-2.2	-2.5	-1.3	1.1	1.3
Ambulatory time before self-admin	1.8	1.9	5.3	1.6	-2.3	-1.5	-1.5	-0.5	0.4	0.9
Ambulatory time after self-admin	0.6	0.6	1.9	0.6	-1.4	-0.6	-0.8	-0.7	0.2	0.7
Bone: tissue strength	0.1	0.1	0.2	-0.1	0.4	0.4	0.2	-0.0	-0.4	0.2
Total heroin consumption	1.5	1.8	4.6	2.2	-1.2	-1.7	-0.9	1.5	-0.1	-0.2
Bone: trabecular number	1.2	1.8	3.4	1.0	-1.5	-1.5	-1.8	-0.8	1.8	-0.3
Bone: trabecular spacing	1.0	1.3	2.5	-0.6	1.6	1.0	1.5	1.2	-1.3	-0.4
Bone: trabecular thickness	0.4	0.5	1.6	-0.4	-0.9	0.3	-0.1	-1.3	-0.1	1.1
Bone: trabecular tissue density	3.7	5.2	8.5	-2.7	2.0	2.9	2.9	-0.6	-2.4	1.4
Water consumed over 24 hours	0.3	0.4	1.1	0.9	0.1	-0.6	-0.2	1.1	-0.0	-0.5
Number of responses in last shaping day	0.3	0.3	0.9	-0.1	0.9	0.1	0.2	0.7	0.1	-0.9