Hub : Genes

Slc22a20

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Slc22a20 0.25 0.1 0.0e+00 0.16 0.16 0.14 0.15 2.0e-17 8.0e-17 2.0e-15 1.1e-16

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
Bone: apparent density0.30.40.40.7
Area under the delay curve0.10.10.1-0.3
BMI with tail2.89.19.13.0
BMI without tail1.02.12.11.4
Body weight4.317.917.94.2
Weight adjusted by age2.32.62.61.6
Bone surface4.57.97.92.8
Bone volume1.42.32.31.5
Breakpoint value in progressive ratio session4.14.54.52.1
Number of licking bursts0.40.50.50.7
Context. condit. distance diff. score2.12.62.6-1.6
Locomotion velocity, session 10.00.00.00.0
Locomotion distance, session 10.30.40.40.7
Locomotion velocity, session 22.83.23.21.8
Locomotion distance, session 20.50.70.70.8
Locomotion velocity, session 30.20.20.2-0.4
Locomotion distance, session 30.10.10.1-0.2
Stereotopy head waving bouts, day 30.50.60.6-0.8
Stereotopy head waving duration, day 30.80.90.9-0.9
Locomotion velocity, session 70.50.60.6-0.8
Locomotion distance, session 70.00.10.1-0.2
Stereotopy head waving bouts, day 70.10.10.1-0.4
Stereotopy head waving duration, day 70.91.11.11.1
Locomotion velocity, session 81.01.21.21.1
Locomotion distance, session 80.20.30.3-0.5
Degree of sensitization distance0.00.00.0-0.0
Degree of sensitization stereotypy0.50.50.50.7
Conditioned locomotion2.02.42.41.5
Cocaine response after cond. corrected1.92.12.1-1.5
Cocaine response after cond. not corrected1.51.61.6-1.3
Cocaine response before conditioning0.81.01.01.0
Saline control response5.26.86.82.6
Bone: connectivity density2.23.53.51.9
Bone: cortical apparent density0.30.40.40.6
Bone: cortical area0.61.01.01.0
Bone: cortical porosity0.10.10.10.3
Bone: cortical porosity0.70.70.70.9
Bone: cortical thickness2.84.54.52.1
Bone: cortical thickness0.50.50.50.7
Bone: cortical tissue density0.40.50.50.7
Condit. Reinf. active minus inactive responses0.20.20.20.4
Condit. Reinf. active-inactive response ratio0.00.00.00.2
Condit. Reinf. active responses0.00.10.10.2
Condit. Reinf. inactive responses0.00.00.0-0.2
Incentive salience index mean0.30.30.30.6
Condit. Reinf. lever presses0.30.40.40.7
Condit. Reinf. active minus inactive responses0.10.10.1-0.4
Condit. Reinf. active-inactive response ratio0.70.70.7-0.9
Condit. Reinf. active responses0.00.00.00.2
Condit. Reinf. inactive responses0.30.40.40.6
Condit. Reinf. lever presses2.43.33.31.8
Condit. Reinf. lever reinforcers received0.20.30.30.6
Conditioned reinforcement - actives0.40.40.4-0.6
Conditioned reinforcement - inactives6.37.17.1-2.7
Conditioned locomotion9.411.311.3-3.4
Patch foraging indifference point 0 sec0.00.00.0-0.1
Patch foraging indifference point AUC3.84.34.32.1
Delay disc. indifference point, 0s delay0.80.90.9-1.0
Delay disc. indifference point, 16s delay0.80.80.8-0.9
Delay disc. indifference point, 2s delay0.10.10.1-0.4
Delay disc. indifference point, 24s delay0.10.10.1-0.3
Delay disc. indifference point, 4s delay0.20.30.3-0.5
Delay disc. indifference point, 8s delay0.10.10.1-0.3
Indifference point function ln k9.613.413.4-3.7
Indifference point function log k9.613.413.4-3.7
Patch foraging total patch changes 0 sec0.00.00.0-0.0
Patch foraging total patch changes 12 sec5.67.27.22.7
Patch foraging total patch changes 18 sec0.60.80.80.9
Patch foraging total patch changes 24 sec2.83.43.41.8
Patch foraging total patch changes 6 sec1.21.81.81.4
Patch foraging time to switch 0 sec2.23.33.31.8
Patch foraging water rate 0 sec4.47.07.0-2.6
Patch foraging water rate 12 sec9.714.914.9-3.9
Patch foraging water rate 18 sec3.74.94.9-2.2
Patch foraging water rate 24 sec5.07.07.0-2.6
Patch foraging water rate 6 sec4.46.56.5-2.5
Seeking ratio, delayed vs. immediate footshock0.00.00.00.0
Distance traveled before self-admin0.70.70.70.8
Distance traveled after self-admin0.30.30.30.6
Extensor digitorum longus weight8.633.933.95.8
Bone: elastic displacement1.31.41.4-1.2
Bone: elastic work0.60.70.70.8
Bone: endosteal estimation0.81.81.8-1.3
Bone: endosteal perimeter1.12.22.2-1.5
Epididymis fat weight3.17.27.2-2.7
Delta time in closed arm before/after self-admin0.00.00.00.1
Delta time in open arm before/after self-admin0.10.10.10.3
Diff in mean of infusions in LGA sessions0.50.50.50.7
Delay discount exponential model param0.10.10.10.3
Extinction: sum of active levers before priming5.75.75.72.4
Active lever presses in extinction session 62.42.42.41.5
Bone: final force3.65.85.82.4
Bone: final moment3.15.05.02.2
Food consumed during 24 hour testing period0.00.00.00.2
Glucose2.23.43.4-1.8
Heart weight4.36.16.1-2.5
Delay discount hyperbolic model param0.00.10.10.2
Intermittent access intake day 1-15 change0.60.60.6-0.8
Intermittent access intake escalation0.50.50.5-0.7
Intermittent access intake escalation 20.10.10.1-0.3
Intermitt. access day 1 inactive lever presses2.72.92.9-1.7
Intermitt. access day 15 inactive lever presses2.93.23.2-1.8
Intermitt. access escalation Index4.43.93.9-2.0
Intermittent access day 1 total infusions6.87.97.9-2.8
Intermittent access day 15 total infusions10.011.211.2-3.4
Intermittent access terminal intake (last 3 days)7.07.77.7-2.8
Intermittent access total infusions6.16.86.8-2.6
Intermittent access day 1 locomotion5.05.35.3-2.3
Intermittent access day 15 total locomotion5.86.26.2-2.5
Intermittent access total locomotion7.38.38.3-2.9
Intermittent access standard deviation1.51.61.6-1.3
Left kidney weight0.72.02.0-1.4
Right kidney weight0.10.20.2-0.5
Cocaine induced anxiety0.00.00.0-0.0
Post-drug Anxiety1.31.51.51.2
Baseline Anxiety3.03.23.21.8
Tail length0.51.41.41.2
Length with tail2.38.48.42.9
Length without tail3.27.17.12.7
Times rat made contact with spout0.40.50.50.7
Lifetime Intake5.25.95.9-2.4
Liver weight, left0.00.00.0-0.2
Liver weight, right0.00.10.1-0.3
Locomotor activity1.93.13.1-1.8
Locomotor testing distance3.05.05.0-2.2
Locomotor testing rearing2.94.54.5-2.1
Locomotion in novel chamber5.46.76.7-2.6
Locomotion in novel chamber post-restriction3.44.14.1-2.0
Fecal boli incidents, locomotor time 10.00.00.00.2
Change in fecal boli incidents, locomotor task0.00.00.00.0
Time >=10cm from walls, locomotor time 10.60.60.6-0.8
Bouts of movement, locomotor time 11.71.91.91.4
Total resting periods, locomotor time 11.21.41.41.2
Rest time, locomotor task time 11.61.71.7-1.3
Distance moved, locomotor task time 10.10.10.10.3
Vertical activity count, locomotor time 11.41.51.5-1.2
Time >=10cm from walls, locomotor time 20.00.00.00.1
Bouts of movement, locomotor time 20.70.70.70.9
Total resting periods, locomotor time 20.30.40.40.6
Rest time, locomotor task time 23.23.73.7-1.9
Distance moved, locomotor task time 21.31.51.51.2
Vertical activity count, locomotor time 20.00.00.00.0
Light reinforcement 10.20.40.4-0.6
Light reinforcement 21.11.51.5-1.2
Bone: marrow area0.91.91.9-1.4
Bone: maximum diameter0.10.20.20.5
Bone: maximum force3.86.56.52.6
Bone: maximum moment3.25.55.52.3
Mean time between licks in bursts0.70.90.91.0
Mean num. licks in bursts0.30.30.3-0.6
Cd content in liver1.31.41.4-1.2
Co content in liver1.51.71.7-1.3
Cu content in liver0.20.20.20.5
Fe content in liver0.10.10.10.3
K content in liver1.61.61.61.3
Mg content in liver0.10.10.10.2
Mn content in liver3.03.43.41.8
Na content in liver1.21.31.31.1
Rb content in liver1.72.22.2-1.5
Se content in liver0.00.00.0-0.1
Sr content in liver4.13.83.81.9
Zn content in liver1.31.51.51.2
Bone: minimum diameter0.81.51.5-1.2
Time in familiar zone, hab. session 10.30.30.3-0.5
Time in novel zone, hab. session 10.10.10.1-0.3
Total zone transitions, hab. session 10.60.90.91.0
Total locomotion distance, hab. session 10.30.40.4-0.7
Locomotion velocity, hab. session 10.00.00.0-0.2
Time in familiar zone, hab. session 20.00.00.0-0.0
Time in novel zone, hab. session 20.00.00.00.2
Total zone transitions, hab. session 21.31.71.71.3
Total locomotion distance, hab. session 20.00.00.0-0.1
Locomotion velocity, hab. session 20.10.10.1-0.3
Novel to familiar place preference ratio1.31.31.31.1
Novelty place preference0.50.50.50.7
Time in novel zone, NPP test0.30.40.40.6
Total zone transitions, NPP test2.53.63.61.9
Total locomotion distance, NPP test0.00.10.10.2
Locomotion velocity, NPP test0.10.10.10.3
Intraocular pressure0.81.21.2-1.1
Delta distance traveled before/after self-admin0.00.00.0-0.1
Delta ambulatory time before/after self-admin0.00.00.00.0
Parametrial fat weight2.44.64.6-2.1
Pavlov. Cond. lever latency0.20.30.3-0.5
Pavlov. Cond. magazine entry latency0.10.10.10.4
Pavlov. Cond. change in total contacts0.00.00.00.2
Pavlov. Cond. index score0.10.10.10.4
Pavlov. Cond. latency score0.00.00.00.2
Pavlov. Cond. lever contacts0.00.00.00.1
Pavlov. Cond. magazine entry number0.20.30.3-0.5
Pavlov. Cond. intertrial magazine entries0.40.50.5-0.7
Pavlov. Cond. lever-magazine prob. diff.0.30.40.40.6
Pavlov. Cond. response bias0.10.10.10.3
Pavlov. Cond. lever latency0.50.70.7-0.8
Pavlov. Cond. magazine entry latency3.94.54.52.1
Pavlov. Cond. change in total contacts2.02.72.71.6
Pavlov. Cond. index score2.63.43.41.8
Pavlov. Cond. latency score2.12.62.61.6
Pavlov. Cond. lever contacts0.50.70.70.9
Pavlov. Cond. magazine entry number7.38.98.9-3.0
Pavlov. Cond. intertrial magazine entries1.41.81.8-1.4
Pavlov. Cond. lever-magazine prob. diff.3.34.14.12.0
Pavlov. Cond. response bias2.02.82.81.7
Time in closed arm before self-admin0.00.00.00.2
Time in closed arm after self-admin0.00.00.0-0.0
Time in open arm before self-admin0.70.80.8-0.9
Time in open arm after self-admin0.20.20.2-0.5
Bone: periosteal estimation0.00.00.0-0.2
Bone: periosteal perimeter0.00.10.10.3
Bone: post-yield work0.40.50.50.7
Progressive ratio test 1 active lever presses4.14.34.3-2.1
Progressive ratio test 1 breakpoint3.73.93.9-2.0
Progressive ratio test 1 inactive lever presses1.71.81.8-1.3
Progressive ratio test 2 active lever presses5.66.06.0-2.5
Progressive ratio test 2 breakpoint6.97.87.8-2.8
Progressive ratio test 2 inactive lever presses10.612.212.2-3.5
Incentive Sensitization - Responses0.50.50.5-0.7
Incentive Sensitization - Breakpoint0.80.80.8-0.9
Sum of active levers in priming session hrs 5-61.81.71.71.3
Progressive ratio2.22.62.61.6
Food seeking constrained by brief footshock0.20.30.30.5
Seeking ratio, punishment vs. effort1.82.22.2-1.5
Retroperitoneal fat weight6.220.420.4-4.5
Reaction time number correct0.20.30.30.5
Reaction time mean minus median3.95.15.12.3
Reaction time mean minus median AUC2.02.52.51.6
Reaction time num false alarms0.20.20.2-0.5
Reaction time num false alarms AUC0.00.00.00.2
Reaction time trials correct on left0.20.30.30.5
Reaction time trials on left0.30.40.40.6
Reaction time mean0.10.10.10.3
Reaction time mean AUC0.00.10.10.2
Median of all reaction times0.00.00.0-0.2
Reaction time omissions1.41.91.91.4
Reaction time false alarm rate0.10.10.1-0.4
Reaction time premature initiation rate2.43.23.21.8
Reaction time premature initiations3.85.45.42.3
Std. dev. reaction times1.11.51.51.2
Reaction time trials completed0.30.40.40.6
Reaction time trials AUC0.10.20.20.4
Run reversals in cocaine runway, females0.50.40.40.7
Run reversals in cocaine runway, males0.20.20.2-0.5
Latency to leave start box in cocaine runway0.00.00.0-0.0
Latency to leave start box in cocaine runway, F0.00.00.00.1
Latency to leave start box in cocaine runway, M0.00.00.00.0
Std. dev. time between licks in bursts0.00.00.0-0.1
Total sessions with >9 infusions2.12.32.3-1.5
Short access day 1 total inactive lever presses4.24.74.7-2.2
Short access day 10 total inactive lever presses3.94.44.4-2.1
Short access day 1 total infusions3.63.83.8-2.0
Short access day 10 total infusions1.92.22.2-1.5
Short access total infusions1.92.12.1-1.5
Short access day 1 locomotion3.13.33.3-1.8
Short access day 10 total locomotion2.32.52.5-1.6
Short access total locomotion2.02.12.1-1.5
One hour access (0.3 mA shock)12.614.814.8-3.8
Compulsive drug intake3.03.13.11.8
One hour access (shock baseline)11.313.113.1-3.6
Social response proportion1.41.61.61.3
Social responses0.30.40.40.6
Social time0.30.30.30.6
Soleus weight4.713.913.9-3.7
Bone: stiffness3.14.94.92.2
Tibialis anterior weight12.442.542.56.5
Time to tail flick, vehicle, before self-admin0.30.30.30.6
Time to tail flick, vehicle, after self-admin1.21.31.31.1
Time to tail flick, test, before self-admin0.90.90.9-0.9
Time to tail flick, test, after self-admin0.00.00.00.1
Delta time to tail flick, vehicle, before/after SA0.40.40.40.7
Delta time to tail flick, test, before/after SA1.51.31.31.1
Tibia length1.23.33.31.8
Ambulatory time before self-admin0.50.50.50.7
Ambulatory time after self-admin0.00.00.0-0.1
Bone: tissue strength0.00.00.00.2
Total heroin consumption6.88.08.02.8
Bone: trabecular number0.40.60.60.8
Bone: trabecular spacing0.20.30.3-0.6
Bone: trabecular thickness0.60.70.7-0.8
Bone: trabecular tissue density3.85.45.4-2.3
Water consumed over 24 hours0.81.01.01.0
Number of responses in last shaping day1.81.81.8-1.4