Arid3c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Arid3c 0.04 0.03 1.7e-04 0.04 0.04 0.04 0.04 5.5e-05 6.3e-05 6.9e-05 6.0e-05
2 IL gene expression Arid3c 0.16 0.11 1.2e-03 0.08 0.05 0.08 0.07 6.9e-03 2.7e-02 5.1e-03 8.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.91.61.7-1.2-1.3
Area under the delay curve0.60.71.00.71.0
BMI with tail1.44.74.8-2.1-2.2
BMI without tail1.95.86.2-2.5-2.3
Body weight3.113.514.3-3.8-3.6
Weight adjusted by age0.10.10.1-0.2-0.4
Bone surface0.71.21.3-1.1-1.1
Bone volume0.51.01.0-1.0-1.0
Breakpoint value in progressive ratio session0.40.51.00.21.0
Number of licking bursts4.87.88.4-2.7-2.9
Context. condit. distance diff. score0.10.20.20.50.4
Locomotion velocity, session 10.50.61.1-1.1-0.2
Locomotion distance, session 10.20.20.5-0.7-0.2
Locomotion velocity, session 21.82.12.2-1.5-1.4
Locomotion distance, session 22.12.93.5-1.9-1.5
Locomotion velocity, session 30.10.10.2-0.4-0.2
Locomotion distance, session 32.02.12.5-1.6-1.3
Stereotopy head waving bouts, day 30.00.00.10.1-0.3
Stereotopy head waving duration, day 30.10.10.10.4-0.2
Locomotion velocity, session 70.10.10.10.30.2
Locomotion distance, session 70.20.30.5-0.7-0.4
Stereotopy head waving bouts, day 71.61.82.3-1.2-1.5
Stereotopy head waving duration, day 71.01.21.6-0.9-1.3
Locomotion velocity, session 80.00.10.1-0.30.0
Locomotion distance, session 80.10.20.3-0.5-0.3
Degree of sensitization distance0.80.80.90.90.9
Degree of sensitization stereotypy1.51.72.0-1.2-1.4
Conditioned locomotion0.00.00.0-0.10.1
Cocaine response after cond. corrected0.91.11.30.91.2
Cocaine response after cond. not corrected0.70.81.10.71.0
Cocaine response before conditioning0.91.01.1-1.0-1.0
Saline control response1.41.81.9-1.3-1.4
Bone: connectivity density0.30.40.4-0.6-0.7
Bone: cortical apparent density0.00.00.00.1-0.1
Bone: cortical area2.74.14.7-1.9-2.2
Bone: cortical porosity0.20.20.30.60.4
Bone: cortical porosity0.00.00.00.0-0.2
Bone: cortical thickness0.81.31.8-0.9-1.3
Bone: cortical thickness0.20.20.30.60.3
Bone: cortical tissue density0.00.00.00.20.0
Condit. Reinf. active minus inactive responses0.50.60.6-0.7-0.8
Condit. Reinf. active-inactive response ratio0.80.80.90.90.9
Condit. Reinf. active responses2.83.53.7-1.8-1.9
Condit. Reinf. inactive responses3.13.84.1-1.9-2.0
Incentive salience index mean4.65.75.7-2.4-2.4
Condit. Reinf. lever presses11.015.416.0-4.0-3.9
Condit. Reinf. active minus inactive responses0.60.81.0-1.0-0.7
Condit. Reinf. active-inactive response ratio0.00.00.0-0.20.1
Condit. Reinf. active responses2.33.23.9-2.0-1.6
Condit. Reinf. inactive responses3.44.44.6-2.0-2.2
Condit. Reinf. lever presses2.73.74.0-1.9-2.0
Condit. Reinf. lever reinforcers received2.73.84.5-2.1-1.8
Conditioned reinforcement - actives0.40.70.9-0.7-0.9
Conditioned reinforcement - inactives0.10.20.30.1-0.6
Conditioned locomotion0.20.30.3-0.5-0.5
Patch foraging indifference point 0 sec0.20.40.8-0.9-0.3
Patch foraging indifference point AUC6.69.510.7-3.3-2.9
Delay disc. indifference point, 0s delay0.80.91.00.91.0
Delay disc. indifference point, 16s delay0.80.81.20.71.1
Delay disc. indifference point, 2s delay0.10.10.2-0.1-0.4
Delay disc. indifference point, 24s delay0.30.30.50.40.7
Delay disc. indifference point, 4s delay0.20.20.30.30.5
Delay disc. indifference point, 8s delay0.00.00.1-0.10.2
Indifference point function ln k1.93.33.41.91.8
Indifference point function log k1.93.33.41.91.8
Patch foraging total patch changes 0 sec0.61.01.5-1.2-0.8
Patch foraging total patch changes 12 sec1.92.42.8-1.7-1.4
Patch foraging total patch changes 18 sec0.50.71.0-1.0-0.6
Patch foraging total patch changes 24 sec1.52.62.9-1.7-1.5
Patch foraging total patch changes 6 sec2.63.95.0-2.2-1.7
Patch foraging time to switch 0 sec1.63.33.51.91.8
Patch foraging water rate 0 sec1.12.32.8-1.7-1.3
Patch foraging water rate 12 sec0.00.00.0-0.0-0.2
Patch foraging water rate 18 sec0.30.40.6-0.5-0.8
Patch foraging water rate 24 sec0.10.10.10.40.1
Patch foraging water rate 6 sec1.21.82.1-1.2-1.5
Seeking ratio, delayed vs. immediate footshock3.54.34.7-2.2-1.9
Distance traveled before self-admin5.77.58.4-2.6-2.9
Distance traveled after self-admin3.34.16.0-1.5-2.4
Extensor digitorum longus weight5.823.024.5-4.6-5.0
Bone: elastic displacement7.38.58.62.92.9
Bone: elastic work2.53.34.12.01.6
Bone: endosteal estimation1.32.82.9-1.7-1.7
Bone: endosteal perimeter1.32.72.9-1.7-1.5
Epididymis fat weight0.20.70.8-0.9-0.8
Delta time in closed arm before/after self-admin0.00.00.1-0.0-0.3
Delta time in open arm before/after self-admin0.00.00.00.00.2
Diff in mean of infusions in LGA sessions0.00.00.00.1-0.1
Delay discount exponential model param0.50.60.9-0.6-0.9
Extinction: sum of active levers before priming2.32.52.81.71.5
Active lever presses in extinction session 60.50.50.60.70.7
Bone: final force2.33.73.8-1.9-2.0
Bone: final moment1.83.03.2-1.7-1.8
Food consumed during 24 hour testing period1.01.41.8-1.3-1.0
Glucose2.03.24.0-2.0-1.6
Heart weight0.40.60.6-0.8-0.7
Delay discount hyperbolic model param0.40.40.7-0.4-0.8
Intermittent access intake day 1-15 change0.61.31.8-0.9-1.3
Intermittent access intake escalation0.61.21.7-0.8-1.3
Intermittent access intake escalation 21.92.23.2-1.1-1.8
Intermitt. access day 1 inactive lever presses0.31.01.2-1.1-0.8
Intermitt. access day 15 inactive lever presses0.10.30.5-0.4-0.7
Intermitt. access escalation Index0.30.40.5-0.7-0.5
Intermittent access day 1 total infusions0.91.52.11.01.4
Intermittent access day 15 total infusions0.10.20.3-0.3-0.6
Intermittent access terminal intake (last 3 days)0.91.21.6-0.9-1.3
Intermittent access total infusions0.30.40.4-0.7-0.6
Intermittent access day 1 locomotion1.51.92.51.21.6
Intermittent access day 15 total locomotion0.91.61.71.21.3
Intermittent access total locomotion1.21.41.71.31.0
Intermittent access standard deviation0.40.80.9-0.9-0.8
Left kidney weight0.52.32.4-1.5-1.5
Right kidney weight0.31.31.6-1.0-1.3
Cocaine induced anxiety0.10.10.1-0.2-0.4
Post-drug Anxiety1.51.61.8-1.3-1.2
Baseline Anxiety0.40.50.6-0.7-0.7
Tail length1.87.17.4-2.7-2.6
Length with tail1.46.27.0-2.6-2.3
Length without tail0.10.20.3-0.6-0.3
Times rat made contact with spout0.50.60.8-0.7-0.9
Lifetime Intake0.50.60.6-0.8-0.7
Liver weight, left0.00.00.00.1-0.0
Liver weight, right0.40.70.80.90.7
Locomotor activity0.00.00.0-0.1-0.1
Locomotor testing distance0.00.10.1-0.00.4
Locomotor testing rearing1.02.02.2-1.5-1.3
Locomotion in novel chamber0.30.30.40.60.5
Locomotion in novel chamber post-restriction1.01.72.3-1.0-1.5
Fecal boli incidents, locomotor time 11.42.02.01.41.4
Change in fecal boli incidents, locomotor task0.70.71.0-1.0-0.7
Time >=10cm from walls, locomotor time 10.10.10.1-0.3-0.2
Bouts of movement, locomotor time 11.31.52.11.41.0
Total resting periods, locomotor time 12.22.43.31.81.2
Rest time, locomotor task time 11.82.33.61.91.0
Distance moved, locomotor task time 12.43.65.1-2.3-1.4
Vertical activity count, locomotor time 11.12.64.2-2.0-1.0
Time >=10cm from walls, locomotor time 20.00.10.1-0.3-0.2
Bouts of movement, locomotor time 20.50.91.0-0.8-1.0
Total resting periods, locomotor time 20.20.30.5-0.4-0.7
Rest time, locomotor task time 20.81.11.81.30.6
Distance moved, locomotor task time 20.60.71.0-1.0-0.6
Vertical activity count, locomotor time 20.81.01.8-1.3-0.6
Light reinforcement 11.33.24.4-2.1-1.4
Light reinforcement 20.60.91.5-1.2-0.7
Bone: marrow area1.43.03.0-1.7-1.7
Bone: maximum diameter2.64.85.2-2.1-2.3
Bone: maximum force4.27.48.1-2.6-2.9
Bone: maximum moment3.45.96.6-2.3-2.6
Mean time between licks in bursts0.20.50.60.60.8
Mean num. licks in bursts2.53.93.92.02.0
Cd content in liver1.41.61.8-1.1-1.4
Co content in liver0.30.30.40.50.6
Cu content in liver1.82.12.61.61.2
Fe content in liver0.50.60.80.60.9
K content in liver0.20.20.20.40.4
Mg content in liver1.21.31.31.11.1
Mn content in liver1.41.62.5-0.8-1.6
Na content in liver1.31.41.91.40.9
Rb content in liver4.75.56.32.22.5
Se content in liver3.13.64.3-1.7-2.1
Sr content in liver0.20.20.4-0.0-0.6
Zn content in liver0.00.00.00.1-0.0
Bone: minimum diameter0.10.10.10.40.2
Time in familiar zone, hab. session 10.60.61.01.00.4
Time in novel zone, hab. session 11.21.21.70.81.3
Total zone transitions, hab. session 10.00.10.10.20.3
Total locomotion distance, hab. session 10.10.10.3-0.2-0.5
Locomotion velocity, hab. session 11.01.51.8-1.1-1.3
Time in familiar zone, hab. session 20.80.91.11.00.8
Time in novel zone, hab. session 20.70.70.80.80.9
Total zone transitions, hab. session 20.50.60.9-0.9-0.5
Total locomotion distance, hab. session 20.70.91.0-1.0-0.9
Locomotion velocity, hab. session 20.91.21.3-1.2-1.0
Novel to familiar place preference ratio2.93.13.51.71.9
Novelty place preference4.04.34.72.02.2
Time in novel zone, NPP test4.95.25.62.22.4
Total zone transitions, NPP test0.50.81.1-1.0-0.7
Total locomotion distance, NPP test1.62.22.7-1.6-1.3
Locomotion velocity, NPP test2.12.93.4-1.9-1.6
Intraocular pressure2.94.25.3-2.3-1.8
Delta distance traveled before/after self-admin0.00.00.00.1-0.1
Delta ambulatory time before/after self-admin0.30.40.60.80.4
Parametrial fat weight0.10.30.50.20.7
Pavlov. Cond. lever latency7.89.910.23.13.2
Pavlov. Cond. magazine entry latency0.40.50.6-0.8-0.6
Pavlov. Cond. change in total contacts3.03.23.2-1.8-1.8
Pavlov. Cond. index score3.44.34.4-2.1-2.1
Pavlov. Cond. latency score3.24.04.2-2.0-2.0
Pavlov. Cond. lever contacts7.38.79.0-2.9-3.0
Pavlov. Cond. magazine entry number0.50.60.70.80.8
Pavlov. Cond. intertrial magazine entries0.20.30.3-0.5-0.5
Pavlov. Cond. lever-magazine prob. diff.3.34.14.3-2.0-2.1
Pavlov. Cond. response bias4.15.05.3-2.3-2.2
Pavlov. Cond. lever latency2.43.33.81.62.0
Pavlov. Cond. magazine entry latency0.10.20.20.50.3
Pavlov. Cond. change in total contacts0.40.60.8-0.7-0.9
Pavlov. Cond. index score0.10.20.3-0.3-0.5
Pavlov. Cond. latency score0.20.30.5-0.4-0.7
Pavlov. Cond. lever contacts1.72.32.8-1.4-1.7
Pavlov. Cond. magazine entry number0.10.10.20.10.4
Pavlov. Cond. intertrial magazine entries0.20.30.4-0.6-0.5
Pavlov. Cond. lever-magazine prob. diff.0.10.20.3-0.3-0.5
Pavlov. Cond. response bias0.71.01.2-0.8-1.1
Time in closed arm before self-admin0.50.71.10.51.0
Time in closed arm after self-admin0.30.30.40.70.5
Time in open arm before self-admin1.11.21.2-1.1-1.1
Time in open arm after self-admin1.11.21.3-1.1-1.1
Bone: periosteal estimation2.14.44.7-2.0-2.2
Bone: periosteal perimeter0.81.31.4-1.2-1.1
Bone: post-yield work2.84.14.2-2.0-2.0
Progressive ratio test 1 active lever presses0.00.00.1-0.3-0.1
Progressive ratio test 1 breakpoint0.10.10.1-0.4-0.2
Progressive ratio test 1 inactive lever presses1.01.51.6-1.3-1.2
Progressive ratio test 2 active lever presses0.00.00.0-0.20.1
Progressive ratio test 2 breakpoint0.00.00.0-0.10.1
Progressive ratio test 2 inactive lever presses0.40.70.7-0.9-0.8
Incentive Sensitization - Responses0.10.20.2-0.5-0.4
Incentive Sensitization - Breakpoint0.10.10.2-0.4-0.2
Sum of active levers in priming session hrs 5-63.23.03.51.61.9
Progressive ratio0.10.10.20.00.5
Food seeking constrained by brief footshock9.211.313.0-3.6-3.1
Seeking ratio, punishment vs. effort3.04.45.1-1.9-2.2
Retroperitoneal fat weight0.62.53.01.51.7
Reaction time number correct0.10.10.3-0.50.1
Reaction time mean minus median0.10.20.30.2-0.5
Reaction time mean minus median AUC0.30.71.3-0.3-1.2
Reaction time num false alarms0.10.20.30.2-0.6
Reaction time num false alarms AUC0.50.81.3-0.5-1.1
Reaction time trials correct on left0.10.10.3-0.50.1
Reaction time trials on left0.10.10.2-0.40.2
Reaction time mean1.52.43.21.81.3
Reaction time mean AUC1.72.83.92.01.3
Median of all reaction times3.14.45.12.31.9
Reaction time omissions2.13.03.31.81.6
Reaction time false alarm rate0.10.20.30.4-0.5
Reaction time premature initiation rate2.73.73.82.01.9
Reaction time premature initiations1.52.73.11.51.8
Std. dev. reaction times0.20.40.80.90.3
Reaction time trials completed0.10.10.2-0.40.2
Reaction time trials AUC0.10.10.2-0.40.2
Run reversals in cocaine runway, females0.20.20.20.40.4
Run reversals in cocaine runway, males0.10.10.10.30.2
Latency to leave start box in cocaine runway0.70.91.1-0.8-1.1
Latency to leave start box in cocaine runway, F0.10.10.10.30.3
Latency to leave start box in cocaine runway, M3.93.64.3-1.7-2.1
Std. dev. time between licks in bursts0.30.40.40.60.6
Total sessions with >9 infusions0.70.80.9-1.0-0.8
Short access day 1 total inactive lever presses1.31.72.1-1.4-1.2
Short access day 10 total inactive lever presses0.41.11.5-0.8-1.2
Short access day 1 total infusions0.91.21.3-1.2-1.0
Short access day 10 total infusions0.10.10.2-0.40.2
Short access total infusions0.20.30.4-0.6-0.3
Short access day 1 locomotion1.21.42.00.91.4
Short access day 10 total locomotion0.91.61.61.31.3
Short access total locomotion0.50.60.90.60.9
One hour access (0.3 mA shock)0.40.40.4-0.6-0.6
Compulsive drug intake0.00.00.0-0.10.1
One hour access (shock baseline)0.20.20.3-0.6-0.4
Social response proportion3.13.53.91.82.0
Social responses0.50.70.9-0.9-0.7
Social time0.00.00.0-0.10.1
Soleus weight0.00.10.2-0.40.3
Bone: stiffness5.59.09.7-2.9-3.1
Tibialis anterior weight9.231.232.4-5.7-5.5
Time to tail flick, vehicle, before self-admin1.81.92.01.41.3
Time to tail flick, vehicle, after self-admin0.00.00.0-0.2-0.1
Time to tail flick, test, before self-admin0.50.50.5-0.7-0.7
Time to tail flick, test, after self-admin0.70.71.0-1.0-0.6
Delta time to tail flick, vehicle, before/after SA0.70.70.8-0.9-0.8
Delta time to tail flick, test, before/after SA0.20.20.20.30.5
Tibia length0.10.30.5-0.7-0.4
Ambulatory time before self-admin4.06.06.4-2.4-2.5
Ambulatory time after self-admin1.61.92.8-1.0-1.7
Bone: tissue strength0.30.30.3-0.6-0.5
Total heroin consumption0.50.60.80.70.9
Bone: trabecular number0.71.21.2-1.0-1.1
Bone: trabecular spacing0.00.10.1-0.1-0.3
Bone: trabecular thickness0.30.40.40.60.6
Bone: trabecular tissue density4.46.46.8-2.5-2.6
Water consumed over 24 hours1.21.61.7-1.2-1.3
Number of responses in last shaping day0.20.20.4-0.60.2