Arid3c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Arid3c 0.04 0.03 1.7e-04 0.04 0.04 0.04 0.04 5.5e-05 6.3e-05 6.9e-05 6.0e-05
2 IL gene expression Arid3c 0.16 0.11 1.2e-03 0.08 0.05 0.08 0.07 6.9e-03 2.7e-02 5.1e-03 8.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.91.61.71.21.3
Area under the delay curve0.50.71.0-0.7-1.0
BMI with tail1.44.74.82.12.2
BMI without tail1.15.86.22.52.3
Body weight3.113.514.33.83.6
Weight adjusted by age0.00.10.10.20.4
Bone surface0.61.21.31.11.1
Bone volume0.51.01.01.01.0
Breakpoint value in progressive ratio session0.30.51.0-0.2-1.0
Number of licking bursts2.67.88.42.72.9
Context. condit. distance diff. score0.10.20.2-0.5-0.4
Locomotion velocity, session 10.50.61.11.10.2
Locomotion distance, session 10.20.20.50.70.2
Locomotion velocity, session 21.82.12.21.51.4
Locomotion distance, session 22.12.93.51.91.5
Locomotion velocity, session 30.10.10.20.40.2
Locomotion distance, session 31.92.12.51.61.3
Stereotopy head waving bouts, day 30.00.00.1-0.10.3
Stereotopy head waving duration, day 30.10.10.1-0.40.2
Locomotion velocity, session 70.10.10.1-0.3-0.2
Locomotion distance, session 70.20.30.50.70.4
Stereotopy head waving bouts, day 71.61.82.31.21.5
Stereotopy head waving duration, day 71.01.21.60.91.3
Locomotion velocity, session 80.00.10.10.3-0.0
Locomotion distance, session 80.10.20.30.50.3
Degree of sensitization distance0.80.80.9-0.9-0.9
Degree of sensitization stereotypy1.51.72.01.21.4
Conditioned locomotion0.00.00.00.1-0.1
Cocaine response after cond. corrected0.71.11.3-0.9-1.2
Cocaine response after cond. not corrected0.60.81.1-0.7-1.0
Cocaine response before conditioning0.81.01.11.01.0
Saline control response1.31.81.91.31.4
Bone: connectivity density0.30.40.40.60.7
Bone: cortical apparent density0.00.00.0-0.10.1
Bone: cortical area2.54.14.71.92.2
Bone: cortical porosity0.20.20.3-0.6-0.4
Bone: cortical porosity0.00.00.0-0.00.2
Bone: cortical thickness0.81.31.80.91.3
Bone: cortical thickness0.20.20.3-0.6-0.3
Bone: cortical tissue density0.00.00.0-0.2-0.0
Condit. Reinf. active minus inactive responses0.50.60.60.70.8
Condit. Reinf. active-inactive response ratio0.80.80.9-0.9-0.9
Condit. Reinf. active responses2.73.53.71.81.9
Condit. Reinf. inactive responses2.93.84.11.92.0
Incentive salience index mean4.45.75.72.42.4
Condit. Reinf. lever presses10.315.416.04.03.9
Condit. Reinf. active minus inactive responses0.50.81.01.00.7
Condit. Reinf. active-inactive response ratio0.00.00.00.2-0.1
Condit. Reinf. active responses2.23.23.92.01.6
Condit. Reinf. inactive responses3.04.44.62.02.2
Condit. Reinf. lever presses2.63.74.01.92.0
Condit. Reinf. lever reinforcers received2.73.84.52.11.8
Conditioned reinforcement - actives0.20.70.90.70.9
Conditioned reinforcement - inactives0.10.20.3-0.10.6
Conditioned locomotion0.20.30.30.50.5
Patch foraging indifference point 0 sec0.10.40.80.90.3
Patch foraging indifference point AUC4.09.510.73.32.9
Delay disc. indifference point, 0s delay0.80.91.0-0.9-1.0
Delay disc. indifference point, 16s delay0.60.81.2-0.7-1.1
Delay disc. indifference point, 2s delay0.10.10.20.10.4
Delay disc. indifference point, 24s delay0.20.30.5-0.4-0.7
Delay disc. indifference point, 4s delay0.20.20.3-0.3-0.5
Delay disc. indifference point, 8s delay0.00.00.10.1-0.2
Indifference point function ln k1.13.33.4-1.9-1.8
Indifference point function log k1.13.33.4-1.9-1.8
Patch foraging total patch changes 0 sec0.41.01.51.20.8
Patch foraging total patch changes 12 sec1.82.42.81.71.4
Patch foraging total patch changes 18 sec0.30.71.01.00.6
Patch foraging total patch changes 24 sec0.82.62.91.71.5
Patch foraging total patch changes 6 sec2.33.95.02.21.7
Patch foraging time to switch 0 sec0.93.33.5-1.9-1.8
Patch foraging water rate 0 sec0.62.32.81.71.3
Patch foraging water rate 12 sec0.00.00.00.00.2
Patch foraging water rate 18 sec0.20.40.60.50.8
Patch foraging water rate 24 sec0.10.10.1-0.4-0.1
Patch foraging water rate 6 sec1.21.82.11.21.5
Seeking ratio, delayed vs. immediate footshock3.04.34.72.21.9
Distance traveled before self-admin3.47.58.42.62.9
Distance traveled after self-admin2.34.16.01.52.4
Extensor digitorum longus weight5.823.024.54.65.0
Bone: elastic displacement6.78.58.6-2.9-2.9
Bone: elastic work2.53.34.1-2.0-1.6
Bone: endosteal estimation1.22.82.91.71.7
Bone: endosteal perimeter1.12.72.91.71.5
Epididymis fat weight0.10.70.80.90.8
Delta time in closed arm before/after self-admin0.00.00.10.00.3
Delta time in open arm before/after self-admin0.00.00.0-0.0-0.2
Diff in mean of infusions in LGA sessions0.00.00.0-0.10.1
Delay discount exponential model param0.40.60.90.60.9
Extinction: sum of active levers before priming1.72.52.8-1.7-1.5
Active lever presses in extinction session 60.50.50.6-0.7-0.7
Bone: final force2.33.73.81.92.0
Bone: final moment1.83.03.21.71.8
Food consumed during 24 hour testing period0.71.41.81.31.0
Glucose2.03.24.02.01.6
Heart weight0.40.60.60.80.7
Delay discount hyperbolic model param0.30.40.70.40.8
Intermittent access intake day 1-15 change0.21.31.80.91.3
Intermittent access intake escalation0.21.21.70.81.3
Intermittent access intake escalation 21.32.23.21.11.8
Intermitt. access day 1 inactive lever presses0.11.01.21.10.8
Intermitt. access day 15 inactive lever presses0.10.30.50.40.7
Intermitt. access escalation Index0.10.40.50.70.5
Intermittent access day 1 total infusions0.51.52.1-1.0-1.4
Intermittent access day 15 total infusions0.10.20.30.30.6
Intermittent access terminal intake (last 3 days)0.71.21.60.91.3
Intermittent access total infusions0.30.40.40.70.6
Intermittent access day 1 locomotion1.01.92.5-1.2-1.6
Intermittent access day 15 total locomotion0.41.61.7-1.2-1.3
Intermittent access total locomotion1.21.41.7-1.3-1.0
Intermittent access standard deviation0.10.80.90.90.8
Left kidney weight0.32.32.41.51.5
Right kidney weight0.21.31.61.01.3
Cocaine induced anxiety0.00.10.10.20.4
Post-drug Anxiety1.41.61.81.31.2
Baseline Anxiety0.30.50.60.70.7
Tail length1.37.17.42.72.6
Length with tail1.46.27.02.62.3
Length without tail0.00.20.30.60.3
Times rat made contact with spout0.50.60.80.70.9
Lifetime Intake0.50.60.60.80.7
Liver weight, left0.00.00.0-0.10.0
Liver weight, right0.40.70.8-0.9-0.7
Locomotor activity0.00.00.00.10.1
Locomotor testing distance0.00.10.10.0-0.4
Locomotor testing rearing0.52.02.21.51.3
Locomotion in novel chamber0.30.30.4-0.6-0.5
Locomotion in novel chamber post-restriction0.61.72.31.01.5
Fecal boli incidents, locomotor time 10.82.02.0-1.4-1.4
Change in fecal boli incidents, locomotor task0.70.71.01.00.7
Time >=10cm from walls, locomotor time 10.10.10.10.30.2
Bouts of movement, locomotor time 11.21.52.1-1.4-1.0
Total resting periods, locomotor time 12.12.43.3-1.8-1.2
Rest time, locomotor task time 11.42.33.6-1.9-1.0
Distance moved, locomotor task time 11.33.65.12.31.4
Vertical activity count, locomotor time 10.42.64.22.01.0
Time >=10cm from walls, locomotor time 20.00.10.10.30.2
Bouts of movement, locomotor time 20.30.91.00.81.0
Total resting periods, locomotor time 20.10.30.50.40.7
Rest time, locomotor task time 20.61.11.8-1.3-0.6
Distance moved, locomotor task time 20.50.71.01.00.6
Vertical activity count, locomotor time 20.41.01.81.30.6
Light reinforcement 10.73.24.42.11.4
Light reinforcement 20.40.91.51.20.7
Bone: marrow area1.23.03.01.71.7
Bone: maximum diameter2.44.85.22.12.3
Bone: maximum force3.87.48.12.62.9
Bone: maximum moment3.15.96.62.32.6
Mean time between licks in bursts0.10.50.6-0.6-0.8
Mean num. licks in bursts1.43.93.9-2.0-2.0
Cd content in liver1.41.61.81.11.4
Co content in liver0.30.30.4-0.5-0.6
Cu content in liver1.72.12.6-1.6-1.2
Fe content in liver0.40.60.8-0.6-0.9
K content in liver0.20.20.2-0.4-0.4
Mg content in liver1.21.31.3-1.1-1.1
Mn content in liver1.41.62.50.81.6
Na content in liver1.21.41.9-1.4-0.9
Rb content in liver4.75.56.3-2.2-2.5
Se content in liver3.13.64.31.72.1
Sr content in liver0.20.20.40.00.6
Zn content in liver0.00.00.0-0.10.0
Bone: minimum diameter0.10.10.1-0.4-0.2
Time in familiar zone, hab. session 10.50.61.0-1.0-0.4
Time in novel zone, hab. session 11.01.21.7-0.8-1.3
Total zone transitions, hab. session 10.00.10.1-0.2-0.3
Total locomotion distance, hab. session 10.10.10.30.20.5
Locomotion velocity, hab. session 11.01.51.81.11.3
Time in familiar zone, hab. session 20.80.91.1-1.0-0.8
Time in novel zone, hab. session 20.70.70.8-0.8-0.9
Total zone transitions, hab. session 20.50.60.90.90.5
Total locomotion distance, hab. session 20.70.91.01.00.9
Locomotion velocity, hab. session 20.91.21.31.21.0
Novel to familiar place preference ratio2.43.13.5-1.7-1.9
Novelty place preference3.44.34.7-2.0-2.2
Time in novel zone, NPP test4.35.25.6-2.2-2.4
Total zone transitions, NPP test0.50.81.11.00.7
Total locomotion distance, NPP test1.62.22.71.61.3
Locomotion velocity, NPP test2.12.93.41.91.6
Intraocular pressure2.64.25.32.31.8
Delta distance traveled before/after self-admin0.00.00.0-0.10.1
Delta ambulatory time before/after self-admin0.20.40.6-0.8-0.4
Parametrial fat weight0.10.30.5-0.2-0.7
Pavlov. Cond. lever latency7.89.910.2-3.1-3.2
Pavlov. Cond. magazine entry latency0.40.50.60.80.6
Pavlov. Cond. change in total contacts2.93.23.21.81.8
Pavlov. Cond. index score3.44.34.42.12.1
Pavlov. Cond. latency score3.24.04.22.02.0
Pavlov. Cond. lever contacts7.28.79.02.93.0
Pavlov. Cond. magazine entry number0.50.60.7-0.8-0.8
Pavlov. Cond. intertrial magazine entries0.20.30.30.50.5
Pavlov. Cond. lever-magazine prob. diff.3.34.14.32.02.1
Pavlov. Cond. response bias4.15.05.32.32.2
Pavlov. Cond. lever latency2.33.33.8-1.6-2.0
Pavlov. Cond. magazine entry latency0.10.20.2-0.5-0.3
Pavlov. Cond. change in total contacts0.30.60.80.70.9
Pavlov. Cond. index score0.10.20.30.30.5
Pavlov. Cond. latency score0.20.30.50.40.7
Pavlov. Cond. lever contacts1.62.32.81.41.7
Pavlov. Cond. magazine entry number0.10.10.2-0.1-0.4
Pavlov. Cond. intertrial magazine entries0.20.30.40.60.5
Pavlov. Cond. lever-magazine prob. diff.0.10.20.30.30.5
Pavlov. Cond. response bias0.71.01.20.81.1
Time in closed arm before self-admin0.40.71.1-0.5-1.0
Time in closed arm after self-admin0.30.30.4-0.7-0.5
Time in open arm before self-admin1.01.21.21.11.1
Time in open arm after self-admin1.11.21.31.11.1
Bone: periosteal estimation1.94.44.72.02.2
Bone: periosteal perimeter0.71.31.41.21.1
Bone: post-yield work2.44.14.22.02.0
Progressive ratio test 1 active lever presses0.00.00.10.30.1
Progressive ratio test 1 breakpoint0.00.10.10.40.2
Progressive ratio test 1 inactive lever presses0.61.51.61.31.2
Progressive ratio test 2 active lever presses0.00.00.00.2-0.1
Progressive ratio test 2 breakpoint0.00.00.00.1-0.1
Progressive ratio test 2 inactive lever presses0.20.70.70.90.8
Incentive Sensitization - Responses0.10.20.20.50.4
Incentive Sensitization - Breakpoint0.00.10.20.40.2
Sum of active levers in priming session hrs 5-63.23.03.5-1.6-1.9
Progressive ratio0.00.10.2-0.0-0.5
Food seeking constrained by brief footshock9.111.313.03.63.1
Seeking ratio, punishment vs. effort2.04.45.11.92.2
Retroperitoneal fat weight0.62.53.0-1.5-1.7
Reaction time number correct0.00.10.30.5-0.1
Reaction time mean minus median0.00.20.3-0.20.5
Reaction time mean minus median AUC0.10.71.30.31.2
Reaction time num false alarms0.10.20.3-0.20.6
Reaction time num false alarms AUC0.30.81.30.51.1
Reaction time trials correct on left0.00.10.30.5-0.1
Reaction time trials on left0.00.10.20.4-0.2
Reaction time mean1.12.43.2-1.8-1.3
Reaction time mean AUC1.22.83.9-2.0-1.3
Median of all reaction times2.84.45.1-2.3-1.9
Reaction time omissions1.83.03.3-1.8-1.6
Reaction time false alarm rate0.10.20.3-0.40.5
Reaction time premature initiation rate2.43.73.8-2.0-1.9
Reaction time premature initiations0.92.73.1-1.5-1.8
Std. dev. reaction times0.10.40.8-0.9-0.3
Reaction time trials completed0.00.10.20.4-0.2
Reaction time trials AUC0.00.10.20.4-0.2
Run reversals in cocaine runway, females0.20.20.2-0.4-0.4
Run reversals in cocaine runway, males0.00.10.1-0.3-0.2
Latency to leave start box in cocaine runway0.60.91.10.81.1
Latency to leave start box in cocaine runway, F0.10.10.1-0.3-0.3
Latency to leave start box in cocaine runway, M3.83.64.31.72.1
Std. dev. time between licks in bursts0.20.40.4-0.6-0.6
Total sessions with >9 infusions0.60.80.91.00.8
Short access day 1 total inactive lever presses0.91.72.11.41.2
Short access day 10 total inactive lever presses0.21.11.50.81.2
Short access day 1 total infusions0.61.21.31.21.0
Short access day 10 total infusions0.10.10.20.4-0.2
Short access total infusions0.20.30.40.60.3
Short access day 1 locomotion0.91.42.0-0.9-1.4
Short access day 10 total locomotion0.41.61.6-1.3-1.3
Short access total locomotion0.40.60.9-0.6-0.9
One hour access (0.3 mA shock)0.30.40.40.60.6
Compulsive drug intake0.00.00.00.1-0.1
One hour access (shock baseline)0.10.20.30.60.4
Social response proportion2.83.53.9-1.8-2.0
Social responses0.50.70.90.90.7
Social time0.00.00.00.1-0.1
Soleus weight0.00.10.20.4-0.3
Bone: stiffness4.99.09.72.93.1
Tibialis anterior weight9.131.232.45.75.5
Time to tail flick, vehicle, before self-admin1.51.92.0-1.4-1.3
Time to tail flick, vehicle, after self-admin0.00.00.00.20.1
Time to tail flick, test, before self-admin0.40.50.50.70.7
Time to tail flick, test, after self-admin0.70.71.01.00.6
Delta time to tail flick, vehicle, before/after SA0.70.70.80.90.8
Delta time to tail flick, test, before/after SA0.10.20.2-0.3-0.5
Tibia length0.10.30.50.70.4
Ambulatory time before self-admin2.06.06.42.42.5
Ambulatory time after self-admin1.21.92.81.01.7
Bone: tissue strength0.30.30.30.60.5
Total heroin consumption0.50.60.8-0.7-0.9
Bone: trabecular number0.61.21.21.01.1
Bone: trabecular spacing0.00.10.10.10.3
Bone: trabecular thickness0.30.40.4-0.6-0.6
Bone: trabecular tissue density3.76.46.82.52.6
Water consumed over 24 hours0.81.61.71.21.3
Number of responses in last shaping day0.20.20.40.6-0.2