Hub : Genes

Arid3c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Arid3c	0.04	0.03	2.9e-04	0.04	0.03	0.03	0.03	4.5e-05	2.7e-04	3.9e-04	1.5e-04
2	IL	gene expression	Arid3c	0.17	0.11	8.9e-04	0.08	0.04	0.06	0.09	6.5e-03	3.3e-02	1.2e-02	3.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.9	1.5	1.7	1.2	-1.3
Area under the delay curve	0.5	0.6	0.7	-0.7	0.8
BMI with tail	1.4	4.6	4.9	2.2	-2.1
BMI without tail	4.7	9.7	10.6	3.3	-3.0
Body weight	2.7	11.5	12.2	3.5	-3.3
Weight adjusted by age	0.2	0.2	0.3	0.2	-0.6
Bone surface	0.7	1.3	1.5	1.1	-1.2
Bone volume	0.7	1.2	1.5	1.0	-1.2
Breakpoint value in progressive ratio session	0.3	0.3	0.4	-0.6	0.5
Number of licking bursts	6.3	7.4	7.6	2.7	-2.8
Context. condit. distance diff. score	0.1	0.1	0.1	-0.3	0.3
Locomotion velocity, session 1	1.0	1.1	1.3	1.1	-0.9
Locomotion distance, session 1	0.5	0.6	0.9	0.9	-0.6
Locomotion velocity, session 2	2.1	2.4	2.5	1.5	-1.6
Locomotion distance, session 2	3.0	4.2	4.3	2.1	-2.0
Locomotion velocity, session 3	0.1	0.1	0.2	0.4	-0.3
Locomotion distance, session 3	2.1	2.3	2.9	1.7	-1.3
Stereotopy head waving bouts, day 3	0.3	0.3	0.7	-0.1	-0.8
Stereotopy head waving duration, day 3	0.2	0.3	0.3	-0.5	-0.6
Locomotion velocity, session 7	0.1	0.1	0.1	-0.4	-0.1
Locomotion distance, session 7	0.2	0.2	0.3	0.6	-0.4
Stereotopy head waving bouts, day 7	3.8	4.3	5.6	1.7	-2.4
Stereotopy head waving duration, day 7	1.7	2.0	3.0	1.0	-1.7
Locomotion velocity, session 8	0.3	0.4	0.5	0.6	-0.7
Locomotion distance, session 8	0.4	0.6	0.7	0.9	-0.6
Degree of sensitization distance	0.8	0.9	1.2	-1.1	0.7
Degree of sensitization stereotypy	2.1	2.3	2.9	1.3	-1.7
Conditioned locomotion	0.0	0.0	0.0	0.2	-0.1
Cocaine response after cond. corrected	0.8	0.9	1.0	-1.0	0.9
Cocaine response after cond. not corrected	0.4	0.5	0.6	-0.8	0.6
Cocaine response before conditioning	1.3	1.6	2.2	1.0	-1.5
Saline control response	2.0	2.7	3.3	1.4	-1.8
Bone: connectivity density	0.2	0.4	0.4	0.6	-0.6
Bone: cortical apparent density	0.1	0.1	0.1	-0.4	0.2
Bone: cortical area	1.9	2.9	3.1	1.7	-1.8
Bone: cortical porosity	0.9	1.0	1.5	-0.7	1.2
Bone: cortical porosity	0.1	0.1	0.3	-0.0	0.5
Bone: cortical thickness	0.3	0.5	0.5	0.7	-0.7
Bone: cortical thickness	0.2	0.2	0.3	-0.5	0.4
Bone: cortical tissue density	0.1	0.1	0.2	-0.4	0.2
Condit. Reinf. active minus inactive responses	0.3	0.4	0.5	0.7	-0.5
Condit. Reinf. active-inactive response ratio	0.9	1.0	1.0	-1.0	1.0
Condit. Reinf. active responses	2.7	3.2	3.3	1.8	-1.8
Condit. Reinf. inactive responses	3.3	4.0	4.4	1.9	-2.1
Incentive salience index mean	4.3	5.2	6.0	2.4	-2.1
Condit. Reinf. lever presses	11.5	15.3	16.5	4.1	-3.8
Condit. Reinf. active minus inactive responses	0.5	0.7	0.8	0.9	-0.7
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.1	0.0
Condit. Reinf. active responses	2.1	2.9	3.1	1.8	-1.6
Condit. Reinf. inactive responses	2.8	3.5	3.8	1.9	-1.8
Condit. Reinf. lever presses	1.6	2.2	2.7	1.3	-1.6
Condit. Reinf. lever reinforcers received	2.4	3.4	3.6	1.9	-1.8
Conditioned reinforcement - actives	0.8	0.8	0.9	1.0	-0.9
Conditioned reinforcement - inactives	0.7	0.8	0.8	0.8	-0.9
Conditioned locomotion	0.5	0.6	0.6	0.8	-0.7
Patch foraging indifference point 0 sec	0.5	0.8	0.8	0.9	-0.9
Patch foraging indifference point AUC	6.1	7.0	8.8	3.0	-2.3
Delay disc. indifference point, 0s delay	0.9	1.0	1.0	-1.0	1.0
Delay disc. indifference point, 16s delay	0.4	0.5	0.6	-0.5	0.8
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	0.1	-0.2
Delay disc. indifference point, 24s delay	0.4	0.4	0.5	-0.5	0.7
Delay disc. indifference point, 4s delay	0.3	0.3	0.3	-0.6	0.5
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.2	0.2
Indifference point function ln k	1.8	2.5	3.5	-1.9	1.2
Indifference point function log k	1.8	2.5	3.5	-1.9	1.2
Patch foraging total patch changes 0 sec	0.9	1.5	1.5	1.2	-1.2
Patch foraging total patch changes 12 sec	1.4	1.9	2.6	1.6	-1.0
Patch foraging total patch changes 18 sec	0.5	0.7	0.8	0.9	-0.7
Patch foraging total patch changes 24 sec	1.9	2.4	2.9	1.7	-1.4
Patch foraging total patch changes 6 sec	2.6	3.9	4.6	2.1	-1.8
Patch foraging time to switch 0 sec	2.4	3.6	3.7	-1.9	1.9
Patch foraging water rate 0 sec	1.4	2.2	2.6	1.6	-1.4
Patch foraging water rate 12 sec	0.1	0.1	0.2	0.1	-0.5
Patch foraging water rate 18 sec	0.1	0.2	0.2	0.5	-0.3
Patch foraging water rate 24 sec	0.1	0.1	0.2	-0.4	0.3
Patch foraging water rate 6 sec	1.4	2.0	2.3	1.3	-1.5
Seeking ratio, delayed vs. immediate footshock	3.5	4.0	4.2	2.0	-2.0
Distance traveled before self-admin	9.1	9.7	10.3	3.0	-3.2
Distance traveled after self-admin	2.6	2.9	3.6	1.5	-1.9
Extensor digitorum longus weight	5.8	22.7	25.5	4.5	-5.0
Bone: elastic displacement	7.1	8.0	8.1	-2.8	2.8
Bone: elastic work	3.3	4.2	4.4	-2.1	2.0
Bone: endosteal estimation	1.8	3.9	4.8	1.8	-2.2
Bone: endosteal perimeter	1.8	3.8	4.6	1.7	-2.1
Epididymis fat weight	0.6	1.4	1.4	1.2	-1.1
Delta time in closed arm before/after self-admin	0.8	0.8	0.9	1.0	-0.8
Delta time in open arm before/after self-admin	0.0	0.0	0.0	-0.2	0.2
Diff in mean of infusions in LGA sessions	0.2	0.2	0.4	-0.6	0.1
Delay discount exponential model param	0.5	0.5	0.6	0.6	-0.8
Extinction: sum of active levers before priming	1.5	1.5	1.6	-1.3	1.2
Active lever presses in extinction session 6	2.0	1.9	2.6	-1.1	1.6
Bone: final force	1.6	2.5	3.2	1.4	-1.8
Bone: final moment	1.1	1.8	2.4	1.1	-1.6
Food consumed during 24 hour testing period	1.1	1.3	1.7	1.3	-1.0
Glucose	0.8	1.3	1.9	1.4	-0.8
Heart weight	0.4	0.6	0.9	1.0	-0.6
Delay discount hyperbolic model param	0.4	0.4	0.5	0.6	-0.7
Intermittent access intake day 1-15 change	0.3	0.3	0.4	0.5	-0.6
Intermittent access intake escalation	0.6	0.6	0.6	0.7	-0.8
Intermittent access intake escalation 2	1.1	1.1	1.2	1.0	-1.1
Intermitt. access day 1 inactive lever presses	0.7	0.8	1.0	1.0	-0.7
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.3	0.6	-0.6
Intermitt. access escalation Index	1.4	1.2	1.2	1.1	-1.1
Intermittent access day 1 total infusions	0.3	0.3	0.4	-0.5	0.7
Intermittent access day 15 total infusions	0.4	0.4	0.5	0.7	-0.6
Intermittent access terminal intake (last 3 days)	1.6	1.8	1.8	1.3	-1.3
Intermittent access total infusions	1.0	1.1	1.2	1.1	-1.0
Intermittent access day 1 locomotion	1.6	1.7	2.1	-1.1	1.4
Intermittent access day 15 total locomotion	1.1	1.2	1.5	-1.0	1.2
Intermittent access total locomotion	0.9	1.0	1.1	-0.9	1.1
Intermittent access standard deviation	0.5	0.5	0.6	0.8	-0.7
Left kidney weight	0.7	1.8	2.3	1.5	-1.2
Right kidney weight	0.1	0.2	0.2	0.4	-0.4
Cocaine induced anxiety	0.3	0.4	0.4	-0.6	0.6
Post-drug Anxiety	0.8	0.9	0.9	1.0	-0.9
Baseline Anxiety	0.4	0.4	0.4	0.6	-0.6
Tail length	2.3	7.0	7.3	2.7	-2.6
Length with tail	0.8	3.1	3.1	1.8	-1.7
Length without tail	0.2	0.5	0.7	-0.8	0.6
Times rat made contact with spout	0.8	0.9	1.2	0.7	-1.1
Lifetime Intake	1.8	2.1	2.3	1.5	-1.4
Liver weight, left	0.6	0.9	1.5	1.2	-0.6
Liver weight, right	0.0	0.0	0.0	0.2	-0.2
Locomotor activity	0.1	0.1	0.1	0.3	0.3
Locomotor testing distance	0.0	0.1	0.1	0.3	0.2
Locomotor testing rearing	1.5	2.3	2.7	1.6	-1.4
Locomotion in novel chamber	0.1	0.2	0.2	-0.4	0.4
Locomotion in novel chamber post-restriction	1.0	1.3	1.7	0.9	-1.3
Fecal boli incidents, locomotor time 1	1.8	2.0	2.1	-1.5	1.4
Change in fecal boli incidents, locomotor task	1.7	1.6	1.7	1.3	-1.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.3	-0.2
Bouts of movement, locomotor time 1	1.5	1.6	2.0	-1.4	1.1
Total resting periods, locomotor time 1	2.4	2.7	3.3	-1.8	1.4
Rest time, locomotor task time 1	2.6	2.8	3.2	-1.8	1.6
Distance moved, locomotor task time 1	3.2	3.6	3.9	2.0	-1.8
Vertical activity count, locomotor time 1	2.3	2.4	3.1	1.8	-1.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	0.3	-0.1
Bouts of movement, locomotor time 2	0.9	0.9	1.2	0.8	-1.1
Total resting periods, locomotor time 2	0.4	0.4	0.6	0.4	-0.8
Rest time, locomotor task time 2	0.9	1.0	1.6	-1.3	0.7
Distance moved, locomotor task time 2	0.3	0.3	0.5	0.7	-0.3
Vertical activity count, locomotor time 2	0.5	0.5	0.9	0.9	-0.4
Light reinforcement 1	2.0	3.6	4.6	2.1	-1.6
Light reinforcement 2	1.0	1.3	1.8	1.4	-0.9
Bone: marrow area	1.9	4.0	4.9	1.8	-2.2
Bone: maximum diameter	2.7	5.0	5.4	2.1	-2.3
Bone: maximum force	3.4	5.9	7.0	2.2	-2.6
Bone: maximum moment	2.5	4.4	5.3	1.9	-2.3
Mean time between licks in bursts	0.2	0.3	0.5	-0.7	0.3
Mean num. licks in bursts	2.8	3.3	3.6	-1.9	1.7
Cd content in liver	1.3	1.4	1.9	1.0	-1.4
Co content in liver	0.7	0.8	1.1	-1.0	0.7
Cu content in liver	0.7	0.9	1.2	-1.1	0.8
Fe content in liver	0.8	1.0	1.4	0.7	-1.2
K content in liver	0.4	0.4	0.5	-0.6	0.7
Mg content in liver	1.5	1.5	1.5	-1.2	1.2
Mn content in liver	0.1	0.1	0.2	-0.1	-0.5
Na content in liver	1.1	1.2	1.2	-1.1	1.1
Rb content in liver	3.8	4.7	5.2	-2.3	2.0
Se content in liver	1.4	1.7	1.9	1.4	-1.2
Sr content in liver	0.3	0.3	0.3	0.4	-0.6
Zn content in liver	0.0	0.0	0.1	-0.2	0.1
Bone: minimum diameter	0.0	0.1	0.1	-0.4	0.0
Time in familiar zone, hab. session 1	0.7	0.7	0.9	-1.0	0.7
Time in novel zone, hab. session 1	0.3	0.3	0.6	-0.8	0.0
Total zone transitions, hab. session 1	0.1	0.1	0.1	0.1	0.4
Total locomotion distance, hab. session 1	0.1	0.1	0.2	0.4	0.3
Locomotion velocity, hab. session 1	0.6	0.9	1.7	1.3	-0.3
Time in familiar zone, hab. session 2	0.9	0.9	1.1	-1.1	0.8
Time in novel zone, hab. session 2	0.3	0.3	0.6	-0.8	0.2
Total zone transitions, hab. session 2	0.5	0.7	1.0	1.0	-0.6
Total locomotion distance, hab. session 2	0.6	0.8	1.2	1.1	-0.6
Locomotion velocity, hab. session 2	0.7	1.0	1.5	1.2	-0.7
Novel to familiar place preference ratio	2.1	2.1	2.7	-1.6	1.3
Novelty place preference	3.3	3.4	4.0	-2.0	1.7
Time in novel zone, NPP test	4.0	4.1	4.9	-2.2	1.8
Total zone transitions, NPP test	0.7	1.1	1.6	1.3	-0.7
Total locomotion distance, NPP test	1.6	2.1	3.2	1.8	-1.0
Locomotion velocity, NPP test	1.8	2.6	4.1	2.0	-1.1
Intraocular pressure	2.5	3.5	4.0	2.0	-1.7
Delta distance traveled before/after self-admin	0.2	0.2	0.2	-0.4	0.4
Delta ambulatory time before/after self-admin	0.8	0.9	1.1	-1.0	0.9
Parametrial fat weight	0.1	0.2	0.3	0.6	-0.2
Pavlov. Cond. lever latency	8.9	11.2	11.4	-3.3	3.4
Pavlov. Cond. magazine entry latency	0.4	0.6	0.7	0.6	-0.9
Pavlov. Cond. change in total contacts	2.9	3.1	3.5	1.9	-1.6
Pavlov. Cond. index score	3.5	4.4	4.7	2.1	-2.2
Pavlov. Cond. latency score	3.4	4.3	4.6	2.0	-2.1
Pavlov. Cond. lever contacts	6.3	7.4	7.9	2.6	-2.8
Pavlov. Cond. magazine entry number	0.6	0.7	0.9	-0.9	0.8
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.2	0.5	-0.3
Pavlov. Cond. lever-magazine prob. diff.	3.0	3.7	3.9	1.8	-2.0
Pavlov. Cond. response bias	3.4	4.1	4.2	2.0	-2.1
Pavlov. Cond. lever latency	2.8	3.8	5.2	-1.5	2.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	-0.6	-0.1
Pavlov. Cond. change in total contacts	0.4	0.5	0.9	0.4	-1.0
Pavlov. Cond. index score	0.3	0.4	0.9	0.1	-0.9
Pavlov. Cond. latency score	0.5	0.6	1.2	0.2	-1.1
Pavlov. Cond. lever contacts	1.5	2.1	3.1	1.0	-1.8
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	0.1	0.6
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.7	0.8	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	0.1	-0.9
Pavlov. Cond. response bias	0.6	0.8	1.4	0.5	-1.2
Time in closed arm before self-admin	3.8	4.3	5.4	-1.8	2.3
Time in closed arm after self-admin	0.6	0.6	0.8	-0.6	0.9
Time in open arm before self-admin	3.7	4.0	4.7	1.8	-2.2
Time in open arm after self-admin	2.2	2.4	2.7	1.5	-1.7
Bone: periosteal estimation	2.1	4.4	5.1	1.9	-2.3
Bone: periosteal perimeter	1.0	1.6	2.1	1.1	-1.4
Bone: post-yield work	2.4	3.3	3.6	1.7	-1.9
Progressive ratio test 1 active lever presses	1.1	1.2	1.3	1.2	-1.0
Progressive ratio test 1 breakpoint	1.5	1.6	1.7	1.3	-1.2
Progressive ratio test 1 inactive lever presses	2.0	2.2	2.5	1.6	-1.4
Progressive ratio test 2 active lever presses	0.7	0.7	0.9	1.0	-0.7
Progressive ratio test 2 breakpoint	0.3	0.3	0.4	0.6	-0.4
Progressive ratio test 2 inactive lever presses	1.0	1.2	1.3	1.1	-1.0
Incentive Sensitization - Responses	0.7	0.7	0.9	1.0	-0.7
Incentive Sensitization - Breakpoint	0.4	0.4	0.6	0.8	-0.5
Sum of active levers in priming session hrs 5-6	3.7	3.5	3.6	-1.9	1.9
Progressive ratio	0.1	0.1	0.2	-0.1	0.4
Food seeking constrained by brief footshock	11.7	14.4	16.2	4.0	-3.6
Seeking ratio, punishment vs. effort	3.9	4.7	4.9	2.1	-2.2
Retroperitoneal fat weight	0.3	0.9	1.0	-0.9	1.0
Reaction time number correct	0.0	0.1	0.1	0.3	-0.1
Reaction time mean minus median	0.0	0.0	0.0	0.0	-0.0
Reaction time mean minus median AUC	0.2	0.3	0.3	0.6	-0.5
Reaction time num false alarms	0.0	0.0	0.0	-0.2	-0.0
Reaction time num false alarms AUC	0.3	0.4	0.4	0.5	-0.7
Reaction time trials correct on left	0.0	0.1	0.1	0.3	-0.1
Reaction time trials on left	0.0	0.0	0.0	0.2	-0.0
Reaction time mean	1.3	1.8	2.6	-1.6	1.0
Reaction time mean AUC	1.5	2.0	3.0	-1.7	1.0
Median of all reaction times	2.2	3.0	4.3	-2.1	1.3
Reaction time omissions	1.3	1.7	2.9	-1.7	0.8
Reaction time false alarm rate	0.0	0.0	0.1	-0.3	0.0
Reaction time premature initiation rate	3.5	4.7	4.8	-2.2	2.1
Reaction time premature initiations	2.5	3.5	3.7	-1.8	1.9
Std. dev. reaction times	0.3	0.5	0.7	-0.8	0.5
Reaction time trials completed	0.0	0.0	0.0	0.2	-0.0
Reaction time trials AUC	0.0	0.0	0.0	0.2	0.0
Run reversals in cocaine runway, females	0.3	0.3	0.5	-0.3	0.7
Run reversals in cocaine runway, males	0.0	0.0	0.0	-0.1	0.1
Latency to leave start box in cocaine runway	0.9	1.0	1.3	0.8	-1.1
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.2	-0.0
Latency to leave start box in cocaine runway, M	3.1	3.0	3.5	1.6	-1.9
Std. dev. time between licks in bursts	0.4	0.5	0.6	-0.8	0.7
Total sessions with >9 infusions	0.7	0.7	0.9	0.9	-0.8
Short access day 1 total inactive lever presses	4.5	5.1	5.8	2.4	-2.1
Short access day 10 total inactive lever presses	0.5	0.5	0.5	0.7	-0.7
Short access day 1 total infusions	4.9	5.3	5.4	2.3	-2.3
Short access day 10 total infusions	0.9	1.0	1.2	1.1	-0.8
Short access total infusions	1.8	2.0	2.3	1.5	-1.3
Short access day 1 locomotion	0.1	0.1	0.2	-0.3	0.4
Short access day 10 total locomotion	1.5	1.6	2.0	-1.1	1.4
Short access total locomotion	0.0	0.0	0.0	0.2	0.1
One hour access (0.3 mA shock)	0.8	0.9	1.0	1.0	-0.9
Compulsive drug intake	0.1	0.1	0.1	0.4	-0.2
One hour access (shock baseline)	0.6	0.7	0.8	0.9	-0.8
Social response proportion	3.7	4.1	5.6	-1.6	2.4
Social responses	0.4	0.5	0.8	0.9	-0.4
Social time	0.0	0.0	0.0	-0.1	-0.1
Soleus weight	0.0	0.1	0.1	0.3	-0.3
Bone: stiffness	4.5	7.1	7.9	2.5	-2.8
Tibialis anterior weight	9.9	33.9	37.7	5.5	-6.1
Time to tail flick, vehicle, before self-admin	2.9	3.0	3.4	-1.9	1.6
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.2	-0.1
Time to tail flick, test, before self-admin	0.5	0.5	0.5	0.7	-0.7
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.1	0.2
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.1	1.0	-0.9
Delta time to tail flick, test, before/after SA	0.7	0.6	0.8	-0.6	0.9
Tibia length	0.1	0.2	0.3	0.5	-0.5
Ambulatory time before self-admin	6.7	6.9	7.1	2.6	-2.7
Ambulatory time after self-admin	1.3	1.4	1.9	0.9	-1.4
Bone: tissue strength	0.1	0.1	0.1	0.4	-0.2
Total heroin consumption	0.0	0.1	0.1	-0.3	0.2
Bone: trabecular number	0.7	1.0	1.1	1.0	-1.0
Bone: trabecular spacing	0.0	0.0	0.0	-0.0	0.0
Bone: trabecular thickness	0.1	0.1	0.3	-0.5	0.0
Bone: trabecular tissue density	3.7	5.3	5.5	2.3	-2.2
Water consumed over 24 hours	1.5	1.8	2.0	1.2	-1.4
Number of responses in last shaping day	1.0	1.1	1.2	1.1	-0.9