Hub : Genes

Qrfpr

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Qrfpr 0.24 0.13 2.4e-03 0.04 0.04 0.04 0.05 3.5e-02 4.7e-02 5.0e-02 2.6e-02
2 Brain mRNA stability Qrfpr 0.43 0.17 0.0e+00 0.28 0.3 0.3 0.31 2.8e-26 9.0e-28 2.4e-28 2.4e-29
3 PL gene expression Qrfpr 0.59 0.12 0.0e+00 0.53 0.56 0.57 0.57 1.8e-68 1.2e-74 5.9e-76 5.1e-76
4 Brain gene expression Qrfpr 0.67 0.1 0.0e+00 0.62 0.64 0.63 0.64 2.3e-74 5.5e-77 6.2e-76 1.6e-76
5 IL gene expression Qrfpr 0.75 0.11 3.4e-12 0.24 0.23 0.24 0.23 1.6e-06 2.9e-06 1.9e-06 2.6e-06
6 OFC mRNA stability Qrfpr 0.46 0.16 6.3e-07 0.29 0.23 0.14 0.26 1.6e-07 3.4e-06 3.6e-04 6.7e-07
7 Adipose gene expression Qrfpr 0.25 0.11 0.0e+00 0.13 0.14 0.14 0.14 2.4e-14 7.5e-15 5.8e-15 5.1e-15
8 PL mRNA stability Qrfpr 0.14 0.08 1.2e-13 0.12 0.11 0.11 0.12 1.6e-13 3.6e-12 1.9e-12 9.5e-13
9 OFC gene expression Qrfpr 0.83 0.08 0.0e+00 0.42 0.4 0.42 0.42 4.3e-11 1.5e-10 3.5e-11 4.0e-11
10 BLA gene expression Qrfpr 0.33 0.12 7.7e-15 0.19 0.17 0.17 0.18 2.9e-10 2.0e-09 1.6e-09 1.0e-09
11 IC gene expression Qrfpr 0.71 0.1 0.0e+00 0.55 0.59 0.58 0.59 2.9e-27 7.0e-30 1.6e-29 5.1e-30
12 BLA mRNA stability Qrfpr 0.16 0.09 4.0e-06 0.06 0.06 0.05 0.05 4.7e-04 6.6e-04 1.1e-03 8.8e-04
13 pVTA gene expression Qrfpr 0.25 0.13 2.5e-14 0.18 0.17 0.17 0.17 3.2e-14 1.8e-13 7.2e-14 2.2e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.10.4-0.40.10.10.30.10.1-0.60.40.20.40.4-0.10.6
Area under the delay curve0.70.91.7-1.30.70.71.00.90.9-1.20.90.70.91.00.90.8
BMI with tail4.816.620.8-4.54.64.44.34.04.0-4.14.04.14.14.14.0-2.3
BMI without tail2.47.211.7-3.42.92.92.92.52.5-2.82.82.62.72.82.6-0.9
Body weight5.423.628.2-5.05.35.15.04.94.9-5.05.15.05.24.74.6-2.8
Weight adjusted by age0.20.30.80.5-0.5-0.4-0.5-0.5-0.50.8-0.7-0.6-0.9-0.6-0.70.1
Bone surface0.51.01.3-0.91.21.11.10.90.9-0.91.01.11.01.10.8-0.8
Bone volume0.10.20.4-0.50.50.40.50.40.4-0.50.60.60.60.50.0-0.1
Breakpoint value in progressive ratio session1.21.51.9-1.01.41.31.31.21.2-1.31.11.31.31.11.3-0.9
Number of licking bursts3.25.26.6-2.32.32.32.42.32.3-2.52.62.52.42.31.9-1.1
Context. condit. distance diff. score0.40.53.5-0.1-0.8-0.7-0.3-0.3-0.3-0.1-0.3-0.5-0.3-0.2-0.91.9
Locomotion velocity, session 10.70.73.6-0.31.21.00.70.60.6-0.30.50.80.60.60.6-1.9
Locomotion distance, session 11.92.45.1-1.22.01.81.51.51.5-0.91.31.61.31.51.3-2.3
Locomotion velocity, session 21.21.44.6-0.81.71.41.11.11.1-0.51.01.21.01.00.6-2.1
Locomotion distance, session 20.81.14.3-0.81.51.31.00.90.9-0.20.81.10.80.90.3-2.1
Locomotion velocity, session 30.00.00.10.20.0-0.0-0.0-0.0-0.0-0.1-0.1-0.1-0.0-0.0-0.1-0.3
Locomotion distance, session 30.00.00.1-0.20.30.20.20.20.2-0.10.20.20.20.2-0.2-0.3
Stereotopy head waving bouts, day 30.20.21.90.40.30.1-0.1-0.2-0.20.6-0.10.1-0.1-0.2-0.1-1.4
Stereotopy head waving duration, day 30.00.00.20.10.10.1-0.00.00.0-0.00.00.10.2-0.00.4-0.4
Locomotion velocity, session 70.40.41.8-0.20.80.70.50.50.5-0.20.50.70.50.40.3-1.3
Locomotion distance, session 71.01.22.71.0-1.0-1.1-1.0-1.2-1.21.2-1.0-1.0-1.1-1.0-1.60.5
Stereotopy head waving bouts, day 71.21.31.9-1.01.41.21.21.21.2-1.21.21.21.31.20.7-1.1
Stereotopy head waving duration, day 70.91.01.5-0.81.21.01.01.01.0-1.11.11.11.21.00.8-0.9
Locomotion velocity, session 80.91.12.6-1.60.91.01.11.01.0-1.21.10.90.91.20.70.4
Locomotion distance, session 80.70.91.9-1.41.01.01.21.01.0-0.91.01.00.91.20.1-0.1
Degree of sensitization distance1.71.72.71.2-1.4-1.4-1.3-1.3-1.31.4-1.3-1.3-1.3-1.3-1.71.0
Degree of sensitization stereotypy1.11.21.9-1.01.11.01.11.11.1-1.41.21.11.31.20.9-0.4
Conditioned locomotion2.93.34.11.8-2.0-2.0-1.8-2.0-2.01.4-1.8-1.9-1.6-1.9-1.91.4
Cocaine response after cond. corrected0.70.83.20.5-1.2-1.1-0.8-0.8-0.80.2-0.7-1.0-0.5-0.7-0.81.8
Cocaine response after cond. not corrected0.60.81.30.9-1.1-1.1-1.0-0.8-0.80.6-0.8-1.0-0.7-0.9-0.50.9
Cocaine response before conditioning0.40.54.20.20.70.60.10.40.40.30.10.40.00.11.1-2.1
Saline control response0.91.24.3-0.51.31.20.90.80.8-0.70.91.20.90.91.4-2.1
Bone: connectivity density1.42.22.7-1.51.61.61.61.31.3-1.61.51.61.51.61.4-1.0
Bone: cortical apparent density0.50.71.61.0-0.8-0.9-0.8-0.8-0.81.1-0.7-0.7-0.9-0.9-1.30.1
Bone: cortical area0.91.31.9-1.41.31.31.31.21.2-1.01.21.21.11.21.0-0.6
Bone: cortical porosity0.30.31.30.2-0.7-0.4-0.4-0.5-0.5-0.0-0.5-0.6-0.5-0.40.61.1
Bone: cortical porosity0.20.21.00.0-0.5-0.2-0.3-0.4-0.4-0.1-0.4-0.5-0.4-0.20.81.0
Bone: cortical thickness0.10.10.40.3-0.5-0.4-0.4-0.3-0.30.2-0.3-0.4-0.4-0.40.10.6
Bone: cortical thickness0.60.71.5-0.60.90.80.81.21.2-0.80.90.90.90.70.8-0.5
Bone: cortical tissue density0.50.71.50.9-0.7-0.8-0.8-0.7-0.71.1-0.7-0.6-0.8-0.8-1.20.0
Condit. Reinf. active minus inactive responses1.11.21.7-0.91.31.21.01.31.3-0.91.21.21.21.01.1-0.7
Condit. Reinf. active-inactive response ratio0.70.81.1-1.00.80.80.81.01.0-0.81.00.81.00.80.90.4
Condit. Reinf. active responses3.84.76.5-1.92.52.42.12.32.3-1.82.22.32.22.12.2-1.8
Condit. Reinf. inactive responses3.94.88.3-1.62.72.52.12.02.0-1.62.02.32.02.12.2-2.9
Incentive salience index mean1.11.31.8-0.91.31.21.11.41.4-0.81.21.21.21.01.1-0.9
Condit. Reinf. lever presses0.81.12.6-0.61.31.20.91.01.0-0.50.91.10.90.91.0-1.6
Condit. Reinf. active minus inactive responses0.81.01.6-0.81.11.10.81.31.3-0.60.80.90.70.81.2-1.1
Condit. Reinf. active-inactive response ratio0.20.20.80.1-0.6-0.5-0.4-0.1-0.10.3-0.5-0.5-0.5-0.4-0.30.9
Condit. Reinf. active responses2.53.45.6-1.42.22.11.62.02.0-1.11.71.91.51.62.1-2.4
Condit. Reinf. inactive responses6.68.512.2-2.13.43.32.73.03.0-2.12.83.12.82.63.1-3.5
Condit. Reinf. lever presses2.02.84.4-1.91.71.71.72.12.1-1.61.61.61.51.71.5-0.6
Condit. Reinf. lever reinforcers received2.43.44.9-1.42.22.11.72.12.1-1.11.61.91.51.62.0-2.2
Conditioned reinforcement - actives0.40.61.40.9-0.3-0.3-0.7-0.7-0.71.2-0.7-0.5-1.0-0.6-0.9-1.1
Conditioned reinforcement - inactives0.81.11.81.4-1.2-1.1-1.2-0.9-0.91.2-0.9-1.0-1.1-1.1-1.10.6
Conditioned locomotion0.60.73.0-1.01.01.10.80.70.70.40.70.7-0.20.7-0.2-1.7
Patch foraging indifference point 0 sec2.75.07.1-2.72.32.22.32.12.1-2.62.52.02.42.22.2-0.3
Patch foraging indifference point AUC0.10.21.5-0.10.40.40.20.20.20.30.10.4-0.20.10.2-1.2
Delay disc. indifference point, 0s delay0.30.40.60.6-0.2-0.3-0.4-0.7-0.70.8-0.6-0.4-0.7-0.6-0.5-0.7
Delay disc. indifference point, 16s delay0.80.92.1-1.40.90.91.01.01.0-1.01.00.80.81.00.80.2
Delay disc. indifference point, 2s delay0.70.81.4-1.00.70.71.00.90.9-1.20.90.80.90.91.00.6
Delay disc. indifference point, 24s delay0.20.20.9-0.1-0.4-0.4-0.2-0.5-0.50.1-0.3-0.4-0.2-0.2-0.41.0
Delay disc. indifference point, 4s delay1.31.32.2-1.21.11.11.21.11.1-1.51.11.11.31.11.5-0.0
Delay disc. indifference point, 8s delay0.20.21.9-0.3-0.3-0.20.0-0.0-0.0-0.30.0-0.2-0.00.1-0.11.4
Indifference point function ln k0.20.33.4-0.6-0.3-0.20.0-0.1-0.1-0.50.0-0.40.30.00.11.8
Indifference point function log k0.20.33.4-0.6-0.3-0.20.0-0.1-0.1-0.50.0-0.40.30.00.11.8
Patch foraging total patch changes 0 sec2.13.95.6-2.32.02.02.01.81.8-2.42.21.82.21.92.0-0.3
Patch foraging total patch changes 12 sec0.00.00.10.3-0.2-0.2-0.3-0.2-0.20.1-0.1-0.1-0.1-0.20.1-0.2
Patch foraging total patch changes 18 sec0.91.31.6-1.11.21.31.11.11.1-1.11.31.21.01.11.3-0.8
Patch foraging total patch changes 24 sec3.15.37.0-2.62.52.42.42.42.4-2.42.52.32.32.22.3-1.1
Patch foraging total patch changes 6 sec1.11.72.6-1.41.31.41.31.11.1-1.61.41.31.31.31.6-0.7
Patch foraging time to switch 0 sec0.51.11.61.1-1.2-1.1-1.1-0.8-0.81.1-0.9-1.0-1.1-1.0-1.20.8
Patch foraging water rate 0 sec0.00.00.1-0.10.1-0.00.10.00.0-0.20.00.10.20.00.3-0.0
Patch foraging water rate 12 sec0.00.10.60.00.30.20.20.40.4-0.2-0.00.30.10.10.2-0.8
Patch foraging water rate 18 sec0.40.60.8-0.70.90.90.80.80.8-0.70.80.90.70.70.7-0.9
Patch foraging water rate 24 sec0.40.61.0-0.51.00.80.90.70.7-0.80.70.90.80.60.6-1.0
Patch foraging water rate 6 sec0.00.00.1-0.10.20.10.10.00.0-0.10.10.1-0.00.10.1-0.4
Seeking ratio, delayed vs. immediate footshock2.73.34.6-2.11.92.02.01.61.6-2.01.91.62.11.91.7-0.5
Distance traveled before self-admin1.92.54.0-2.01.81.71.61.81.8-1.41.71.61.31.51.5-0.9
Distance traveled after self-admin4.45.49.3-3.12.72.62.52.42.4-1.72.52.31.72.31.8-1.6
Extensor digitorum longus weight5.120.123.3-4.84.74.74.74.54.5-4.84.64.64.64.74.5-1.8
Bone: elastic displacement1.11.37.20.1-1.4-1.2-0.8-0.8-0.80.5-0.8-1.2-0.8-0.7-0.92.7
Bone: elastic work2.53.36.21.2-2.2-2.0-1.8-1.7-1.71.5-1.7-2.0-1.7-1.7-1.52.5
Bone: endosteal estimation2.86.08.2-2.72.92.72.72.52.5-2.02.42.52.32.61.7-2.1
Bone: endosteal perimeter1.02.24.3-1.51.81.81.61.41.4-0.71.31.51.11.50.8-2.1
Epididymis fat weight2.79.311.8-3.23.23.13.23.23.2-3.43.03.03.33.03.1-1.1
Delta time in closed arm before/after self-admin0.60.60.8-0.80.80.70.70.70.7-0.80.80.80.90.60.9-0.5
Delta time in open arm before/after self-admin1.01.01.51.0-1.1-1.1-1.0-1.0-1.00.5-1.1-1.1-0.7-1.0-0.71.2
Diff in mean of infusions in LGA sessions0.70.81.5-1.10.60.70.91.21.2-1.11.00.80.71.00.70.3
Delay discount exponential model param0.70.81.61.2-0.6-0.6-0.9-0.8-0.81.2-0.9-0.6-0.9-0.9-0.9-1.0
Extinction: sum of active levers before priming0.10.10.7-0.10.50.30.20.40.4-0.10.10.30.20.10.1-0.8
Active lever presses in extinction session 60.10.10.2-0.10.00.20.20.40.4-0.50.50.30.40.20.30.4
Bone: final force2.23.54.8-1.92.02.01.91.91.9-1.62.02.01.81.82.2-1.3
Bone: final moment2.23.64.5-2.02.02.01.91.91.9-1.72.02.01.91.92.1-1.0
Food consumed during 24 hour testing period0.91.22.1-1.51.21.21.31.21.2-1.11.21.11.01.30.5-0.1
Glucose0.20.31.40.3-0.3-0.4-0.5-0.5-0.51.2-0.5-0.6-0.7-0.5-0.3-0.2
Heart weight2.94.56.2-2.22.22.12.12.12.1-2.42.12.12.52.12.5-0.5
Delay discount hyperbolic model param0.80.91.61.2-0.6-0.6-0.9-0.9-0.91.3-0.9-0.7-0.9-0.9-1.0-1.0
Intermittent access intake day 1-15 change1.53.03.92.0-1.8-1.7-1.8-1.7-1.71.9-1.8-1.8-1.9-1.6-1.80.9
Intermittent access intake escalation1.12.23.11.8-1.6-1.5-1.5-1.5-1.51.6-1.5-1.5-1.6-1.4-1.60.6
Intermittent access intake escalation 20.60.71.00.7-0.8-0.7-0.8-0.9-0.91.0-0.8-0.9-1.0-0.7-1.00.4
Intermitt. access day 1 inactive lever presses0.10.40.70.8-0.8-0.8-0.8-0.5-0.50.5-0.7-0.6-0.6-0.6-0.50.3
Intermitt. access day 15 inactive lever presses0.91.84.42.1-1.6-1.4-1.5-1.4-1.40.8-1.5-1.3-0.9-1.4-0.60.6
Intermitt. access escalation Index0.20.41.01.0-0.7-0.8-0.7-0.5-0.5-0.0-0.5-0.50.1-0.70.00.6
Intermittent access day 1 total infusions1.21.94.02.0-0.9-1.0-1.3-1.2-1.21.9-1.2-0.9-1.4-1.4-1.4-1.7
Intermittent access day 15 total infusions1.92.95.72.4-1.4-1.4-1.8-1.5-1.52.3-1.6-1.3-1.8-1.7-1.8-0.9
Intermittent access terminal intake (last 3 days)3.04.07.32.5-1.7-1.6-2.0-2.0-2.02.7-1.9-1.7-2.3-1.9-2.3-0.8
Intermittent access total infusions0.91.14.71.5-0.2-0.4-0.8-0.8-0.81.4-0.8-0.3-0.9-0.9-0.8-2.2
Intermittent access day 1 locomotion0.50.65.3-0.20.80.70.30.30.30.80.30.5-0.20.2-0.4-2.3
Intermittent access day 15 total locomotion0.61.12.1-1.51.21.31.21.21.20.11.00.90.11.1-0.1-1.3
Intermittent access total locomotion1.11.34.7-1.31.41.41.21.01.00.21.01.10.11.00.0-2.2
Intermittent access standard deviation0.30.71.81.3-1.0-0.9-0.9-0.9-0.90.5-0.8-0.8-0.5-0.9-0.40.8
Left kidney weight0.52.23.8-1.71.41.21.61.51.5-1.81.61.42.01.51.00.4
Right kidney weight1.46.410.4-2.72.32.32.52.52.5-3.22.82.43.12.52.50.3
Cocaine induced anxiety1.42.05.7-2.41.71.61.81.01.0-1.31.31.11.31.61.1-0.2
Post-drug Anxiety0.90.91.8-1.00.90.91.00.60.6-1.30.90.81.31.01.30.0
Baseline Anxiety1.31.55.02.2-1.6-1.5-1.6-0.9-0.90.5-1.0-0.9-0.6-1.4-0.40.7
Tail length0.10.40.8-0.70.50.50.60.50.5-0.90.90.60.80.50.50.1
Length with tail1.25.07.0-1.92.32.12.22.32.3-2.62.62.42.62.02.1-1.2
Length without tail3.611.514.1-3.13.63.43.43.83.8-3.63.53.63.73.23.2-1.9
Times rat made contact with spout0.20.20.5-0.70.50.50.50.50.5-0.20.50.40.30.6-0.3-0.3
Lifetime Intake0.91.14.31.7-0.3-0.4-0.9-0.9-0.91.4-0.8-0.4-0.8-1.0-0.8-2.1
Liver weight, left0.10.10.40.30.1-0.0-0.1-0.1-0.10.6-0.2-0.1-0.2-0.2-0.4-0.6
Liver weight, right0.30.61.11.0-0.9-0.8-0.8-1.0-1.00.4-0.5-0.7-0.5-0.7-0.50.7
Locomotor activity0.30.51.71.3-0.7-0.7-0.9-0.8-0.80.4-0.6-0.6-0.5-0.80.30.1
Locomotor testing distance1.62.86.4-0.91.91.81.41.51.5-1.71.71.71.71.32.5-1.7
Locomotor testing rearing0.00.10.40.5-0.2-0.1-0.4-0.3-0.30.1-0.0-0.20.0-0.40.60.0
Locomotion in novel chamber2.32.94.1-1.81.91.81.71.71.7-1.72.01.81.91.71.5-1.0
Locomotion in novel chamber post-restriction0.00.00.30.10.10.10.00.10.1-0.30.20.20.20.10.5-0.1
Fecal boli incidents, locomotor time 11.52.23.31.8-1.8-1.7-1.5-1.2-1.21.2-1.5-1.4-1.5-1.4-1.41.4
Change in fecal boli incidents, locomotor task1.81.82.8-1.41.71.51.51.11.1-1.21.41.41.41.31.3-1.3
Time >=10cm from walls, locomotor time 10.10.10.80.20.1-0.1-0.2-0.3-0.30.3-0.3-0.0-0.2-0.2-0.1-0.9
Bouts of movement, locomotor time 11.31.42.10.7-1.2-1.1-1.2-1.4-1.41.3-0.9-1.3-1.3-1.0-1.21.3
Total resting periods, locomotor time 12.52.83.71.4-1.9-1.7-1.7-1.9-1.91.6-1.3-1.7-1.6-1.5-1.51.9
Rest time, locomotor task time 11.51.93.11.3-1.6-1.3-1.4-1.2-1.21.5-1.4-1.4-1.8-1.1-1.70.7
Distance moved, locomotor task time 12.23.34.7-2.02.21.91.91.61.6-1.81.91.92.01.61.9-1.1
Vertical activity count, locomotor time 11.84.35.6-2.32.32.02.12.02.0-2.12.32.12.41.92.3-0.9
Time >=10cm from walls, locomotor time 20.40.60.90.9-0.6-0.7-0.7-0.9-0.90.8-1.0-0.7-0.7-0.7-0.9-0.3
Bouts of movement, locomotor time 22.53.95.72.3-2.4-2.1-2.2-2.0-2.01.9-1.8-2.0-1.9-1.8-1.71.6
Total resting periods, locomotor time 21.73.04.52.0-2.1-1.8-1.9-1.7-1.71.6-1.5-1.8-1.7-1.5-1.31.5
Rest time, locomotor task time 20.10.20.40.3-0.6-0.4-0.5-0.3-0.30.4-0.4-0.5-0.6-0.3-0.20.5
Distance moved, locomotor task time 21.31.52.7-1.41.61.31.31.01.0-1.11.11.21.31.01.1-1.2
Vertical activity count, locomotor time 21.11.53.8-1.01.71.31.20.90.9-0.81.11.21.20.91.0-2.0
Light reinforcement 10.61.43.11.8-1.2-1.3-1.4-1.3-1.31.0-1.2-1.1-1.1-1.3-0.40.3
Light reinforcement 20.40.61.61.3-0.8-0.8-0.8-0.9-0.90.6-0.9-0.7-0.6-0.7-0.80.1
Bone: marrow area3.06.58.7-2.82.92.82.82.62.6-2.22.52.62.42.71.7-2.0
Bone: maximum diameter1.12.03.0-1.61.71.71.61.41.4-1.01.31.41.31.51.0-1.3
Bone: maximum force0.71.21.5-1.21.21.21.11.11.1-0.81.21.21.01.11.1-0.8
Bone: maximum moment0.71.21.7-1.31.21.21.21.11.1-0.91.21.21.01.21.1-0.5
Mean time between licks in bursts0.00.00.10.2-0.2-0.2-0.20.30.3-0.0-0.0-0.0-0.0-0.2-0.10.3
Mean num. licks in bursts2.03.14.51.5-1.8-1.7-1.8-1.8-1.82.1-2.0-2.0-2.0-1.7-1.70.9
Cd content in liver1.11.32.21.5-1.1-1.0-1.1-1.1-1.11.3-1.3-1.1-1.3-1.1-1.10.0
Co content in liver1.01.11.9-1.41.11.21.21.11.1-1.01.01.00.91.10.9-0.2
Cu content in liver0.30.40.5-0.50.70.60.70.60.6-0.60.60.70.70.60.0-0.4
Fe content in liver0.50.60.80.7-0.9-0.9-0.8-0.8-0.80.5-0.7-0.8-0.7-0.8-0.50.6
K content in liver0.60.51.10.6-0.8-1.0-0.7-0.6-0.60.6-0.6-0.7-0.6-0.8-1.00.7
Mg content in liver0.20.20.90.1-0.5-0.6-0.4-0.2-0.20.1-0.1-0.3-0.0-0.4-0.71.0
Mn content in liver2.22.42.91.3-1.7-1.7-1.6-1.7-1.71.7-1.5-1.6-1.4-1.6-1.31.1
Na content in liver1.01.11.9-0.71.21.01.01.11.1-0.71.11.21.00.90.7-1.4
Rb content in liver0.20.20.8-0.50.20.20.30.30.3-0.70.40.30.50.30.90.6
Se content in liver2.63.14.21.8-1.6-1.8-1.8-1.8-1.82.1-1.8-1.8-1.7-1.8-1.90.3
Sr content in liver0.10.10.30.6-0.2-0.1-0.2-0.2-0.20.5-0.2-0.1-0.2-0.20.0-0.5
Zn content in liver0.40.40.7-0.60.70.50.70.70.7-0.70.70.70.90.6-0.2-0.2
Bone: minimum diameter2.13.95.9-2.42.32.22.22.02.0-1.61.91.91.82.11.5-1.3
Time in familiar zone, hab. session 10.00.00.2-0.00.10.10.0-0.1-0.10.3-0.1-0.0-0.1-0.0-0.4-0.4
Time in novel zone, hab. session 10.10.10.20.3-0.2-0.1-0.3-0.3-0.30.1-0.1-0.1-0.1-0.20.5-0.1
Total zone transitions, hab. session 11.31.93.3-1.61.41.51.41.31.3-1.31.31.31.31.51.8-0.5
Total locomotion distance, hab. session 10.91.23.4-0.91.21.31.00.90.9-0.91.01.11.01.01.8-1.0
Locomotion velocity, hab. session 10.91.33.7-1.01.21.31.11.01.0-1.01.01.21.01.11.9-0.8
Time in familiar zone, hab. session 24.64.96.52.6-2.4-2.3-2.4-2.3-2.32.1-2.3-2.3-2.3-2.3-1.70.8
Time in novel zone, hab. session 23.83.85.9-2.42.22.12.11.91.9-1.92.12.02.02.11.7-0.5
Total zone transitions, hab. session 23.24.05.5-1.82.42.22.12.12.1-1.51.92.11.92.01.9-1.9
Total locomotion distance, hab. session 21.62.13.0-1.11.61.61.41.51.5-1.01.31.61.31.41.7-1.6
Locomotion velocity, hab. session 22.02.64.0-1.11.91.81.51.71.7-1.11.41.81.41.51.8-2.0
Novel to familiar place preference ratio0.30.33.3-0.7-0.3-0.20.0-0.1-0.1-0.40.2-0.20.10.10.31.8
Novelty place preference0.40.44.0-0.7-0.4-0.3-0.0-0.2-0.2-0.40.1-0.20.10.10.22.0
Time in novel zone, NPP test0.50.53.8-1.1-0.10.00.30.10.1-0.80.40.00.40.40.51.9
Total zone transitions, NPP test0.50.74.4-0.01.11.00.70.60.6-0.10.50.90.50.60.6-2.1
Total locomotion distance, NPP test0.30.43.20.30.70.60.30.30.3-0.00.30.70.20.30.6-1.8
Locomotion velocity, NPP test0.20.33.00.80.30.3-0.1-0.1-0.10.5-0.20.3-0.2-0.20.4-1.7
Intraocular pressure0.81.22.31.5-1.3-1.2-1.3-1.2-1.21.0-1.0-1.0-0.9-1.2-0.80.4
Delta distance traveled before/after self-admin0.20.20.7-0.90.60.60.60.40.4-0.10.60.40.10.50.0-0.3
Delta ambulatory time before/after self-admin0.20.30.8-0.90.60.70.60.40.4-0.30.50.40.30.60.2-0.3
Parametrial fat weight0.51.11.7-0.91.31.31.21.01.0-0.91.01.11.11.00.9-1.0
Pavlov. Cond. lever latency0.60.82.40.4-1.2-1.0-0.8-0.8-0.80.5-0.8-1.0-0.8-0.7-0.61.6
Pavlov. Cond. magazine entry latency2.83.64.7-1.82.22.12.12.02.0-1.81.92.11.91.91.3-1.5
Pavlov. Cond. change in total contacts0.60.61.2-0.51.00.90.80.80.8-0.40.70.90.70.70.4-1.1
Pavlov. Cond. index score2.73.45.1-1.52.32.11.91.91.9-1.41.82.11.81.71.2-2.1
Pavlov. Cond. latency score2.02.64.5-1.22.01.81.61.61.6-1.11.61.81.51.51.0-2.1
Pavlov. Cond. lever contacts1.21.43.0-0.71.51.31.11.21.2-0.71.11.41.11.00.7-1.7
Pavlov. Cond. magazine entry number4.55.77.32.4-2.7-2.6-2.6-2.5-2.52.2-2.5-2.6-2.4-2.4-1.51.6
Pavlov. Cond. intertrial magazine entries0.91.11.61.2-1.1-1.2-1.2-0.9-0.91.0-1.0-1.1-1.0-1.1-0.60.6
Pavlov. Cond. lever-magazine prob. diff.2.43.04.4-1.42.11.91.81.81.8-1.41.71.91.71.71.1-2.0
Pavlov. Cond. response bias3.54.35.9-2.02.42.32.22.22.2-1.82.22.32.12.11.3-1.7
Pavlov. Cond. lever latency4.76.48.62.5-2.7-2.6-2.5-2.9-2.92.5-2.4-2.6-2.5-2.6-2.41.4
Pavlov. Cond. magazine entry latency2.12.54.4-2.11.31.41.71.91.9-1.81.61.41.61.70.90.7
Pavlov. Cond. change in total contacts4.26.78.8-2.42.82.72.63.03.0-2.52.52.72.52.62.6-1.7
Pavlov. Cond. index score6.68.911.6-3.33.13.13.13.43.4-3.03.03.03.03.12.6-1.1
Pavlov. Cond. latency score5.87.710.1-3.12.92.82.93.23.2-2.82.72.82.72.92.3-1.0
Pavlov. Cond. lever contacts5.17.19.2-2.62.92.82.73.03.0-2.62.62.72.62.72.4-1.6
Pavlov. Cond. magazine entry number5.77.010.73.3-2.6-2.6-2.9-3.0-3.02.8-2.7-2.5-2.6-2.8-2.00.1
Pavlov. Cond. intertrial magazine entries0.00.10.50.20.00.1-0.1-0.1-0.10.2-0.3-0.0-0.3-0.10.2-0.7
Pavlov. Cond. lever-magazine prob. diff.6.28.210.8-3.13.02.93.03.33.3-2.92.82.92.83.02.4-1.1
Pavlov. Cond. response bias5.17.09.6-2.72.72.72.73.13.1-2.72.62.62.62.72.5-1.1
Time in closed arm before self-admin0.81.11.61.0-1.2-1.1-1.0-1.1-1.10.9-0.9-1.0-1.2-0.8-1.01.0
Time in closed arm after self-admin0.30.30.50.5-0.7-0.6-0.6-0.5-0.50.6-0.3-0.4-0.7-0.5-0.50.3
Time in open arm before self-admin5.96.48.2-2.92.62.62.62.92.9-2.32.72.62.42.52.3-1.3
Time in open arm after self-admin0.30.30.7-0.50.50.50.50.50.5-0.80.40.40.80.50.60.3
Bone: periosteal estimation2.34.96.7-2.62.62.52.52.32.3-1.82.22.22.12.41.6-1.6
Bone: periosteal perimeter0.30.61.5-0.70.90.90.80.60.6-0.40.50.80.50.80.7-1.2
Bone: post-yield work0.30.50.8-0.90.90.70.80.60.6-0.30.70.80.50.7-0.2-0.7
Progressive ratio test 1 active lever presses0.70.97.90.31.00.90.40.40.40.30.40.70.20.20.3-2.8
Progressive ratio test 1 breakpoint0.81.08.90.21.11.00.40.50.50.20.40.80.30.20.3-3.0
Progressive ratio test 1 inactive lever presses0.50.72.31.5-0.4-0.6-0.9-0.6-0.61.0-0.7-0.4-0.5-0.9-0.6-1.4
Progressive ratio test 2 active lever presses0.70.97.01.00.30.1-0.3-0.1-0.11.3-0.20.1-0.6-0.5-0.7-2.7
Progressive ratio test 2 breakpoint0.70.86.71.00.30.1-0.3-0.1-0.11.3-0.20.1-0.6-0.5-0.7-2.6
Progressive ratio test 2 inactive lever presses0.71.22.71.6-0.8-0.8-1.2-1.0-1.01.4-1.0-0.9-1.1-1.1-1.1-0.8
Incentive Sensitization - Responses0.40.52.10.40.0-0.1-0.3-0.2-0.21.4-0.4-0.3-0.9-0.5-1.1-1.3
Incentive Sensitization - Breakpoint0.40.52.20.5-0.0-0.2-0.4-0.3-0.31.5-0.4-0.3-0.9-0.5-1.1-1.2
Sum of active levers in priming session hrs 5-60.20.20.70.8-0.2-0.2-0.3-0.3-0.30.4-0.6-0.2-0.3-0.4-0.0-0.9
Progressive ratio0.00.00.20.10.10.1-0.10.00.00.40.0-0.1-0.1-0.0-0.2-0.2
Food seeking constrained by brief footshock2.73.35.4-1.61.51.61.72.02.0-2.31.81.82.11.72.3-0.2
Seeking ratio, punishment vs. effort0.71.02.3-0.90.70.70.91.01.0-1.51.01.01.10.91.30.3
Retroperitoneal fat weight2.812.116.3-3.64.03.93.73.53.5-3.13.43.53.53.43.3-2.6
Reaction time number correct0.51.02.61.5-0.3-0.6-0.8-1.0-1.01.2-0.9-0.6-0.9-0.9-0.7-1.6
Reaction time mean minus median1.33.26.7-2.61.31.61.82.02.0-2.01.71.41.61.91.71.1
Reaction time mean minus median AUC0.82.14.9-2.21.11.31.61.71.7-1.61.31.11.31.51.30.8
Reaction time num false alarms0.10.10.20.2-0.4-0.3-0.4-0.5-0.50.1-0.3-0.4-0.4-0.4-0.10.1
Reaction time num false alarms AUC0.10.20.40.5-0.5-0.4-0.5-0.6-0.60.3-0.4-0.4-0.5-0.6-0.3-0.2
Reaction time trials correct on left0.51.02.61.5-0.3-0.6-0.8-1.0-1.01.2-0.9-0.6-0.9-0.9-0.7-1.6
Reaction time trials on left0.50.92.31.5-0.4-0.6-0.8-1.0-1.01.2-0.9-0.6-0.9-0.9-0.7-1.5
Reaction time mean0.71.22.4-1.50.30.71.01.21.2-1.50.80.70.81.11.11.5
Reaction time mean AUC0.61.03.0-1.50.10.50.81.11.1-1.30.60.50.61.01.01.7
Median of all reaction times0.30.42.8-0.7-0.4-0.00.30.60.6-0.90.10.10.10.40.61.7
Reaction time omissions0.50.75.7-0.9-0.40.00.30.60.6-1.10.40.10.40.60.62.4
Reaction time false alarm rate0.00.00.2-0.3-0.10.10.0-0.0-0.0-0.40.20.00.2-0.00.30.3
Reaction time premature initiation rate5.17.110.22.5-3.2-2.8-2.8-2.7-2.72.5-2.5-2.7-2.8-2.5-2.62.1
Reaction time premature initiations3.97.09.13.0-2.9-2.7-2.8-2.8-2.82.8-2.6-2.6-2.8-2.6-2.50.9
Std. dev. reaction times2.24.07.9-2.81.51.82.12.22.2-2.51.91.61.92.11.91.1
Reaction time trials completed0.50.92.31.5-0.4-0.6-0.8-1.0-1.01.2-0.9-0.6-0.9-0.9-0.7-1.5
Reaction time trials AUC0.50.92.41.5-0.3-0.5-0.8-0.9-0.91.2-0.8-0.6-0.9-0.8-0.6-1.6
Run reversals in cocaine runway, females0.20.20.7-0.20.70.60.40.30.3-0.30.50.50.50.40.5-0.8
Run reversals in cocaine runway, males1.11.11.5-1.01.21.11.01.01.0-0.81.01.11.01.01.0-1.1
Latency to leave start box in cocaine runway0.20.32.0-0.4-0.2-0.00.10.50.5-0.40.50.10.30.40.01.4
Latency to leave start box in cocaine runway, F0.30.32.8-0.1-0.6-0.4-0.3-0.1-0.10.10.2-0.3-0.20.1-0.51.7
Latency to leave start box in cocaine runway, M0.50.41.0-0.40.20.40.40.80.8-1.00.70.60.80.60.70.5
Std. dev. time between licks in bursts0.81.01.9-0.80.80.80.91.21.2-1.41.11.11.20.91.0-0.0
Total sessions with >9 infusions0.70.82.41.3-0.3-0.4-0.8-0.9-0.91.3-0.7-0.5-0.7-0.9-0.9-1.5
Short access day 1 total inactive lever presses0.20.30.80.7-0.2-0.3-0.5-0.6-0.60.9-0.4-0.4-0.4-0.5-0.7-0.6
Short access day 10 total inactive lever presses0.20.41.1-1.10.60.50.70.60.6-0.70.60.40.50.70.50.4
Short access day 1 total infusions0.50.71.61.3-0.3-0.4-0.8-0.7-0.71.3-0.7-0.5-0.6-0.8-0.9-1.2
Short access day 10 total infusions0.50.73.71.4-0.1-0.2-0.7-0.6-0.60.8-0.5-0.1-0.3-0.7-0.3-1.9
Short access total infusions1.01.34.11.7-0.4-0.5-1.0-1.0-1.01.5-0.8-0.5-0.9-1.1-1.0-2.0
Short access day 1 locomotion1.11.42.6-1.61.51.41.21.11.1-0.71.31.20.71.20.8-1.0
Short access day 10 total locomotion0.40.71.7-1.31.11.10.90.80.8-0.40.70.80.40.90.4-0.9
Short access total locomotion0.80.93.7-1.01.31.20.80.80.8-0.00.91.00.40.80.3-1.9
One hour access (0.3 mA shock)0.50.65.3-0.10.90.70.50.40.40.50.30.6-0.20.3-0.2-2.3
Compulsive drug intake4.75.69.1-3.02.62.42.62.42.4-2.22.42.42.12.32.1-1.5
One hour access (shock baseline)1.72.55.02.2-1.2-1.2-1.5-1.6-1.62.1-1.6-1.3-1.7-1.6-1.7-0.9
Social response proportion5.05.67.52.2-2.6-2.4-2.3-2.3-2.32.5-2.6-2.6-2.5-2.2-2.71.4
Social responses0.10.10.3-0.0-0.0-0.1-0.2-0.3-0.30.5-0.4-0.3-0.5-0.2-0.6-0.2
Social time7.19.615.13.9-3.7-3.6-3.3-2.9-2.92.3-3.3-3.1-2.6-3.1-2.52.5
Soleus weight0.92.66.6-2.61.11.31.71.21.2-2.21.71.31.61.71.21.5
Bone: stiffness0.81.21.7-0.91.31.21.11.01.0-0.91.11.21.01.01.2-1.3
Tibialis anterior weight8.629.335.2-5.55.95.95.75.45.4-5.55.55.65.45.65.2-3.2
Time to tail flick, vehicle, before self-admin1.11.22.21.3-1.5-1.4-1.2-0.9-0.90.7-1.0-1.1-0.9-1.0-0.61.4
Time to tail flick, vehicle, after self-admin2.33.04.82.0-1.7-1.7-1.8-1.5-1.52.2-1.7-1.7-2.0-1.7-1.90.1
Time to tail flick, test, before self-admin1.21.33.5-1.90.70.91.11.01.0-1.41.20.70.91.20.91.2
Time to tail flick, test, after self-admin0.20.20.9-1.00.20.30.50.10.1-0.50.20.10.10.50.40.9
Delta time to tail flick, vehicle, before/after SA2.52.43.91.7-1.3-1.3-1.5-1.5-1.52.0-1.6-1.5-1.7-1.6-1.9-0.3
Delta time to tail flick, test, before/after SA0.10.10.20.3-0.1-0.1-0.1-0.3-0.30.4-0.4-0.2-0.3-0.2-0.2-0.4
Tibia length0.71.84.12.0-0.8-1.0-1.1-1.2-1.21.7-1.1-0.8-1.3-1.3-1.8-1.3
Ambulatory time before self-admin1.11.62.1-1.41.51.31.31.51.5-1.01.51.31.01.11.1-1.1
Ambulatory time after self-admin1.82.23.9-2.01.81.71.61.51.5-0.81.71.40.91.41.0-1.4
Bone: tissue strength1.31.32.60.8-1.5-1.3-1.2-1.2-1.20.8-0.9-1.2-1.2-1.1-0.41.6
Total heroin consumption0.40.40.9-0.90.70.70.80.60.6-0.60.50.50.50.80.60.1
Bone: trabecular number0.10.10.6-0.10.10.10.2-0.1-0.1-0.80.30.30.50.30.50.2
Bone: trabecular spacing0.30.41.40.5-0.3-0.4-0.5-0.3-0.31.2-0.5-0.5-0.6-0.6-1.0-0.4
Bone: trabecular thickness0.10.10.7-0.0-0.2-0.30.00.00.0-0.2-0.00.0-0.10.1-0.60.8
Bone: trabecular tissue density2.03.04.51.8-2.1-2.0-1.8-1.5-1.51.4-1.6-1.7-1.7-1.8-1.91.6
Water consumed over 24 hours1.62.23.7-1.91.61.51.71.51.5-1.51.61.41.51.70.8-0.4
Number of responses in last shaping day0.20.20.6-0.70.80.70.60.30.3-0.10.30.40.20.60.1-0.6