Qrfpr

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Qrfpr 0.55 0.11 0.0e+00 0.51 0.54 0.53 0.53 2.9e-64 8.1e-70 1.0e-68 1.6e-68
2 LHb gene expression Qrfpr 0.25 0.14 1.5e-03 0.02 0.04 0.02 0.02 1.0e-01 3.9e-02 1.1e-01 1.0e-01
3 PL mRNA stability Qrfpr 0.14 0.07 3.1e-13 0.1 0.09 0.09 0.09 7.1e-11 2.1e-10 7.1e-10 2.7e-10
4 Brain gene expression Qrfpr 0.7 0.1 0.0e+00 0.61 0.63 0.64 0.64 1.4e-70 6.0e-76 5.3e-77 1.5e-77
5 BLA gene expression Qrfpr 0.36 0.13 8.9e-16 0.21 0.18 0.19 0.18 2.2e-11 8.6e-10 2.8e-10 3.4e-10
6 Brain mRNA stability Qrfpr 0.4 0.15 0.0e+00 0.27 0.28 0.28 0.28 3.1e-25 5.8e-26 8.8e-26 2.9e-26
7 Adipose gene expression Qrfpr 0.26 0.12 0.0e+00 0.14 0.14 0.13 0.14 8.4e-15 5.6e-15 3.4e-14 2.2e-15
8 OFC gene expression Qrfpr 0.82 0.08 0.0e+00 0.41 0.38 0.37 0.39 8.4e-11 5.9e-10 1.2e-09 3.0e-10
9 BLA mRNA stability Qrfpr 0.14 0.08 1.9e-05 0.02 0.04 0.02 0.03 4.1e-02 3.7e-03 3.0e-02 1.6e-02
10 IL gene expression Qrfpr 0.76 0.11 1.5e-12 0.26 0.27 0.29 0.31 7.1e-07 2.9e-07 8.9e-08 3.7e-08
11 RMTg gene expression Qrfpr 0.14 0.09 7.3e-03 0.05 0.06 0.03 0.07 1.4e-02 9.7e-03 4.6e-02 6.6e-03
12 OFC mRNA stability Qrfpr 0.46 0.16 4.6e-07 0.22 0.25 0.24 0.26 5.6e-06 1.1e-06 1.8e-06 5.3e-07
13 pVTA gene expression Qrfpr 0.17 0.09 2.3e-05 0.11 0.06 0.06 0.08 2.1e-05 1.5e-03 1.0e-03 2.5e-04
14 Eye gene expression Qrfpr 0.36 0.18 7.9e-03 0.1 0.04 0.07 0.07 1.3e-02 7.3e-02 3.5e-02 3.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.20.30.9-0.0-0.6-0.40.4-0.40.2-0.6-0.40.6-0.30.8-0.8-1.00.8
Area under the delay curve0.91.02.30.7-1.4-1.00.9-0.90.6-1.1-1.01.50.20.8-0.8-0.81.5
BMI with tail5.517.926.34.8-5.1-4.94.9-4.74.7-5.1-5.05.04.1-1.71.51.53.0
BMI without tail2.24.57.72.1-2.7-2.52.4-2.32.1-2.8-2.32.81.8-0.40.10.22.3
Body weight5.121.629.75.2-5.1-5.45.3-5.35.3-5.5-5.04.95.2-2.72.92.72.3
Weight adjusted by age0.20.30.7-0.40.50.8-0.50.8-0.50.80.6-0.4-0.50.1-0.0-0.00.0
Bone surface0.50.81.31.0-0.7-1.11.0-1.11.1-1.0-1.00.71.0-0.90.70.50.1
Bone volume0.10.10.30.2-0.4-0.60.5-0.60.5-0.6-0.50.30.3-0.1-0.0-0.20.0
Breakpoint value in progressive ratio session1.61.82.61.6-1.2-1.41.4-1.41.6-1.4-1.51.21.6-1.21.21.20.4
Number of licking bursts3.44.06.02.1-2.1-2.52.4-2.52.4-2.3-2.21.92.4-1.21.21.40.6
Context. condit. distance diff. score0.81.03.5-0.8-0.40.2-0.20.2-0.5-0.20.20.3-0.91.8-1.9-1.90.9
Locomotion velocity, session 11.21.34.11.00.1-0.60.7-0.61.0-0.2-0.5-0.21.4-1.82.01.9-1.3
Locomotion distance, session 12.02.55.21.9-0.8-1.31.5-1.31.8-1.0-1.40.62.0-2.32.32.0-0.7
Locomotion velocity, session 21.72.04.91.4-0.3-0.91.0-0.91.4-0.5-1.0-0.11.8-2.12.22.1-1.6
Locomotion distance, session 21.31.84.91.3-0.3-0.91.0-0.91.4-0.5-0.90.01.7-2.02.22.1-1.3
Locomotion velocity, session 30.00.00.00.00.20.1-0.10.1-0.00.00.1-0.20.0-0.2-0.00.0-0.2
Locomotion distance, session 30.10.10.30.10.0-0.20.2-0.20.2-0.1-0.1-0.20.5-0.30.30.4-0.5
Stereotopy head waving bouts, day 30.40.52.10.10.70.1-0.20.10.10.40.2-0.80.5-1.30.90.8-1.4
Stereotopy head waving duration, day 30.00.00.20.30.0-0.20.1-0.20.1-0.2-0.10.10.1-0.40.0-0.10.1
Locomotion velocity, session 70.70.82.00.8-0.1-0.60.6-0.60.8-0.3-0.5-0.11.1-1.41.41.4-1.0
Locomotion distance, session 70.60.71.4-1.01.00.9-0.90.9-0.81.01.0-1.2-0.40.4-0.00.1-1.1
Stereotopy head waving bouts, day 70.91.01.81.2-0.9-1.21.2-1.21.3-1.1-1.10.71.4-1.00.50.5-0.3
Stereotopy head waving duration, day 70.50.71.11.0-0.7-0.91.0-0.91.0-0.8-0.80.61.1-0.90.40.5-0.2
Locomotion velocity, session 80.81.01.90.9-1.4-1.11.2-1.11.0-1.3-1.11.30.60.4-0.5-0.51.0
Locomotion distance, session 80.60.81.50.8-1.2-1.11.1-1.11.1-1.2-1.10.91.0-0.00.10.20.3
Degree of sensitization distance1.11.11.6-1.31.01.2-1.21.2-1.21.21.1-1.1-1.00.9-0.6-0.5-0.7
Degree of sensitization stereotypy0.70.81.31.0-1.0-1.01.1-1.01.1-1.1-1.00.90.9-0.4-0.1-0.00.4
Conditioned locomotion2.53.04.4-2.11.81.9-2.01.9-2.01.82.0-1.7-1.91.5-1.1-1.0-0.4
Cocaine response after cond. corrected1.11.24.0-1.10.20.6-0.70.6-1.00.20.6-0.0-1.21.7-1.9-2.01.0
Cocaine response after cond. not corrected0.70.81.8-1.00.70.8-0.90.8-1.00.50.8-0.5-1.00.8-1.2-1.40.3
Cocaine response before conditioning0.70.84.40.80.5-0.10.2-0.10.50.1-0.2-0.40.7-2.11.51.4-1.0
Saline control response0.81.04.51.00.2-0.60.5-0.60.9-0.2-0.5-0.10.9-2.11.71.5-0.8
Bone: connectivity density1.11.82.71.5-1.4-1.61.6-1.61.6-1.6-1.61.31.2-0.90.80.60.5
Bone: cortical apparent density0.50.71.5-0.91.00.8-0.80.8-0.70.90.9-1.2-0.50.10.30.3-1.2
Bone: cortical area0.60.91.51.1-1.1-1.21.2-1.21.1-1.2-1.11.00.9-0.60.20.20.5
Bone: cortical porosity0.91.06.00.1-0.60.00.10.0-0.2-0.5-0.11.2-1.01.0-1.2-1.42.4
Bone: cortical porosity0.70.73.8-0.1-0.10.4-0.30.4-0.5-0.00.20.8-1.20.9-1.2-1.32.0
Bone: cortical thickness0.20.31.0-0.30.00.2-0.20.2-0.3-0.00.30.2-0.80.6-0.9-1.00.9
Bone: cortical thickness0.30.40.70.6-0.4-0.80.6-0.80.7-0.5-0.50.40.6-0.70.80.7-0.1
Bone: cortical tissue density0.50.71.7-0.91.00.8-0.80.8-0.70.90.8-1.2-0.40.00.40.3-1.3
Condit. Reinf. active minus inactive responses0.80.91.41.1-0.9-1.21.0-1.21.1-0.9-1.20.81.1-0.80.90.80.1
Condit. Reinf. active-inactive response ratio0.60.61.20.7-1.1-0.90.8-0.90.7-0.9-1.01.10.40.2-0.1-0.10.9
Condit. Reinf. active responses3.03.75.32.3-1.7-2.22.1-2.22.2-1.8-2.21.62.1-1.91.81.70.2
Condit. Reinf. inactive responses3.84.67.92.5-1.3-2.12.1-2.12.4-1.6-2.01.22.5-2.82.82.6-0.6
Incentive salience index mean0.91.01.41.2-0.9-1.21.1-1.21.2-0.9-1.20.81.2-1.01.00.9-0.0
Condit. Reinf. lever presses0.81.02.71.1-0.3-0.80.8-0.81.0-0.5-0.80.31.2-1.61.61.4-0.7
Condit. Reinf. active minus inactive responses0.40.51.61.0-0.4-0.60.7-0.60.8-0.4-0.70.50.8-1.30.60.8-0.0
Condit. Reinf. active-inactive response ratio0.30.41.2-0.50.20.5-0.40.5-0.60.30.4-0.0-0.70.7-1.1-1.00.5
Condit. Reinf. active responses1.92.66.22.0-0.8-1.41.5-1.41.8-1.0-1.40.82.0-2.52.12.1-0.5
Condit. Reinf. inactive responses5.67.011.83.1-1.5-2.62.6-2.63.0-2.0-2.41.43.2-3.43.43.3-0.6
Condit. Reinf. lever presses1.52.13.01.7-1.7-1.61.7-1.61.6-1.6-1.71.71.3-0.80.50.51.1
Condit. Reinf. lever reinforcers received1.92.75.62.0-0.9-1.41.6-1.41.8-1.0-1.50.92.0-2.42.12.1-0.4
Conditioned reinforcement - actives1.41.42.9-1.11.31.2-1.21.7-1.31.61.0-1.5-1.2-0.0-0.4-0.4-1.1
Conditioned reinforcement - inactives0.91.01.7-1.21.01.0-1.01.3-1.21.01.0-1.0-1.31.0-0.9-0.9-0.1
Conditioned locomotion0.91.13.71.2-0.6-0.80.60.20.70.4-1.10.00.7-1.91.51.5-1.4
Patch foraging indifference point 0 sec2.84.47.12.0-2.6-2.62.4-2.42.2-2.7-2.42.61.8-0.50.0-0.02.2
Patch foraging indifference point AUC0.50.62.40.60.2-0.10.2-0.20.40.10.1-0.20.7-1.51.51.5-0.7
Delay disc. indifference point, 0s delay0.80.92.7-0.31.10.8-0.70.9-0.51.10.7-1.2-0.0-0.81.01.0-1.6
Delay disc. indifference point, 16s delay0.80.81.90.9-1.4-1.11.0-1.00.8-1.0-1.11.30.40.1-0.2-0.20.9
Delay disc. indifference point, 2s delay0.50.51.20.5-1.0-0.70.7-0.70.5-0.8-0.81.00.30.7-0.5-0.41.1
Delay disc. indifference point, 24s delay0.40.41.2-0.6-0.00.5-0.30.4-0.60.20.30.0-0.81.1-1.1-1.10.5
Delay disc. indifference point, 4s delay1.21.32.21.1-1.3-1.41.2-1.31.2-1.5-1.31.40.9-0.10.20.21.2
Delay disc. indifference point, 8s delay0.50.51.9-0.2-0.5-0.10.10.0-0.2-0.3-0.10.6-0.61.4-1.3-1.31.1
Indifference point function ln k0.81.24.4-0.4-0.7-0.30.1-0.2-0.2-0.5-0.30.8-0.81.9-2.0-2.11.3
Indifference point function log k0.81.24.4-0.4-0.7-0.30.1-0.2-0.2-0.5-0.30.8-0.81.9-2.0-2.11.3
Patch foraging total patch changes 0 sec2.33.75.91.9-2.3-2.42.2-2.22.0-2.4-2.12.41.6-0.50.10.02.1
Patch foraging total patch changes 12 sec0.00.00.1-0.10.1-0.20.0-0.10.0-0.00.30.00.0-0.30.30.30.3
Patch foraging total patch changes 18 sec1.11.42.41.3-1.2-1.51.3-1.41.3-1.3-1.21.21.3-1.00.70.71.1
Patch foraging total patch changes 24 sec3.74.66.42.4-2.3-2.52.5-2.52.4-2.5-2.22.32.3-1.20.91.01.7
Patch foraging total patch changes 6 sec1.11.72.81.5-1.5-1.51.5-1.41.3-1.5-1.41.71.1-0.80.50.41.4
Patch foraging time to switch 0 sec0.71.01.5-1.21.01.1-1.21.1-1.21.21.0-1.1-1.10.9-0.8-0.6-0.1
Patch foraging water rate 0 sec0.00.00.10.1-0.1-0.10.2-0.10.1-0.3-0.00.30.10.0-0.2-0.20.2
Patch foraging water rate 12 sec0.20.31.00.50.1-0.30.2-0.20.5-0.1-0.2-0.10.6-1.01.00.8-0.5
Patch foraging water rate 18 sec0.50.71.10.9-0.5-1.00.9-0.81.0-0.8-0.80.51.0-0.91.10.9-0.1
Patch foraging water rate 24 sec0.60.91.81.0-0.5-0.80.9-0.81.1-0.8-0.90.41.3-1.11.31.2-0.4
Patch foraging water rate 6 sec0.00.10.30.30.0-0.00.20.00.2-0.0-0.20.00.2-0.50.30.3-0.3
Seeking ratio, delayed vs. immediate footshock2.73.14.92.0-2.2-2.12.1-2.11.9-2.1-2.02.21.3-0.50.20.21.3
Distance traveled before self-admin0.60.71.00.9-0.8-1.00.9-0.90.9-0.8-0.80.70.9-0.70.80.80.2
Distance traveled after self-admin2.83.14.82.2-2.1-2.12.0-1.81.9-1.7-2.21.81.7-1.11.21.20.7
Extensor digitorum longus weight3.915.521.44.4-4.6-4.54.6-4.54.5-4.6-4.64.53.7-1.71.91.82.7
Bone: elastic displacement1.92.17.0-1.2-0.20.8-0.70.8-1.10.30.60.5-1.82.7-2.4-2.22.0
Bone: elastic work2.43.15.9-2.00.81.5-1.61.5-1.81.21.5-0.6-2.42.4-2.4-2.31.1
Bone: endosteal estimation2.14.57.52.5-2.0-2.32.4-2.32.5-2.2-2.51.62.7-1.91.71.8-0.2
Bone: endosteal perimeter0.91.83.61.6-0.8-1.01.2-1.01.4-0.8-1.40.51.7-1.91.81.8-0.8
Epididymis fat weight2.66.210.62.9-2.0-2.32.6-2.53.0-2.5-2.41.93.3-2.52.72.60.2
Delta time in closed arm before/after self-admin0.80.81.51.0-0.6-0.70.9-1.01.1-0.9-0.60.61.2-1.11.11.1-0.0
Delta time in open arm before/after self-admin0.40.40.6-0.80.50.7-0.70.4-0.70.30.7-0.3-0.70.7-0.8-0.80.4
Diff in mean of infusions in LGA sessions1.11.32.21.0-1.5-1.41.2-1.21.1-1.5-1.31.50.70.2-0.3-0.31.4
Delay discount exponential model param1.11.12.8-0.61.41.0-0.90.9-0.61.21.0-1.5-0.1-1.01.01.0-1.7
Extinction: sum of active levers before priming0.40.41.00.7-0.3-0.60.5-0.60.8-0.5-0.30.21.0-0.71.01.0-0.4
Active lever presses in extinction session 60.10.10.30.3-0.3-0.40.4-0.40.4-0.5-0.40.40.30.0-0.1-0.00.5
Bone: final force1.62.63.71.9-1.6-1.91.8-1.91.9-1.8-1.71.71.5-1.31.21.01.0
Bone: final moment1.72.73.91.9-1.7-2.01.9-2.01.9-1.9-1.81.91.5-1.01.00.81.2
Food consumed during 24 hour testing period0.91.11.81.0-1.3-1.31.3-1.31.2-1.2-1.31.01.1-0.20.40.30.2
Glucose0.20.41.6-0.50.70.5-0.60.5-0.50.80.6-0.7-0.40.1-0.1-0.1-1.2
Heart weight0.60.91.91.0-0.9-0.81.0-1.11.0-1.4-0.71.20.8-0.10.0-0.11.4
Delay discount hyperbolic model param1.01.02.6-0.51.30.9-0.80.8-0.51.10.9-1.4-0.1-1.00.90.9-1.6
Intermittent access intake day 1-15 change2.92.84.9-1.82.21.9-1.91.9-1.82.01.9-2.2-1.60.6-0.5-0.5-1.4
Intermittent access intake escalation2.72.63.9-1.82.01.8-1.81.8-1.81.81.8-1.9-1.71.0-0.9-0.9-0.8
Intermittent access intake escalation 20.60.60.9-0.70.80.8-0.80.8-0.81.00.7-0.9-0.90.4-0.4-0.4-0.5
Intermitt. access day 1 inactive lever presses0.10.20.3-0.40.50.5-0.40.4-0.40.50.4-0.5-0.30.10.20.2-0.5
Intermitt. access day 15 inactive lever presses1.21.33.1-1.31.61.8-1.21.3-1.10.91.5-1.3-0.90.5-0.6-0.6-0.2
Intermitt. access escalation Index0.10.10.20.10.0-0.20.2-0.40.3-0.50.10.10.3-0.00.10.10.1
Intermittent access day 1 total infusions1.41.63.4-0.91.61.2-1.31.6-0.91.61.1-1.8-0.4-1.00.60.6-1.8
Intermittent access day 15 total infusions2.62.95.8-1.62.31.8-1.82.2-1.62.21.7-2.4-1.3-0.2-0.0-0.0-1.9
Intermittent access terminal intake (last 3 days)3.43.87.8-1.52.52.0-2.02.5-1.72.71.7-2.8-1.2-0.70.40.4-2.6
Intermittent access total infusions1.71.84.5-0.61.81.2-1.11.5-0.71.61.1-1.9-0.1-1.51.21.2-2.1
Intermittent access day 1 locomotion0.50.51.90.8-0.5-0.70.40.10.50.2-0.80.10.5-1.41.01.0-0.8
Intermittent access day 15 total locomotion0.30.31.30.7-0.7-0.70.40.30.30.4-1.10.20.0-0.40.30.3-0.5
Intermittent access total locomotion0.81.02.41.2-0.8-0.80.70.00.80.1-1.30.30.8-1.51.31.3-1.0
Intermittent access standard deviation0.90.91.6-1.21.11.3-1.00.9-1.00.61.0-0.8-1.00.8-1.0-1.00.2
Left kidney weight0.10.30.90.5-0.6-0.50.7-0.70.8-0.7-0.50.40.9-0.20.30.40.1
Right kidney weight0.51.52.51.3-1.4-1.31.5-1.41.5-1.6-1.31.31.5-0.50.50.60.6
Cocaine induced anxiety2.02.35.12.1-1.9-1.41.7-1.21.6-1.1-2.31.51.3-1.51.11.10.2
Post-drug Anxiety2.02.23.41.8-1.4-1.51.6-1.41.7-1.4-1.81.31.7-1.51.31.30.4
Baseline Anxiety0.50.51.9-0.90.40.1-0.40.1-0.5-0.30.7-0.0-0.51.4-1.0-1.00.9
Tail length0.10.20.50.3-0.4-0.60.4-0.50.4-0.7-0.10.50.5-0.10.10.20.4
Length with tail0.83.05.01.8-1.7-2.11.9-2.12.0-2.2-1.51.72.2-1.01.21.10.8
Length without tail2.75.98.62.6-2.4-2.92.7-2.92.9-2.8-2.62.22.9-1.52.01.80.6
Times rat made contact with spout0.10.20.40.4-0.4-0.40.5-0.40.4-0.1-0.50.00.4-0.30.40.4-0.6
Lifetime Intake1.71.94.2-0.71.91.2-1.11.4-0.71.51.2-2.0-0.0-1.61.21.2-2.1
Liver weight, left0.20.41.10.3-0.2-0.60.5-0.60.6-0.5-0.30.01.0-0.40.80.9-0.8
Liver weight, right0.10.10.4-0.40.50.3-0.40.4-0.40.30.4-0.4-0.20.2-0.0-0.0-0.7
Locomotor activity0.20.30.8-0.60.90.7-0.60.5-0.60.40.9-0.4-0.50.1-0.4-0.40.4
Locomotor testing distance1.42.33.21.7-1.0-1.61.7-1.81.7-1.8-1.31.41.7-1.51.11.21.2
Locomotor testing rearing0.10.10.8-0.10.40.2-0.10.1-0.2-0.00.3-0.0-0.2-0.2-0.3-0.20.9
Locomotion in novel chamber2.63.34.92.0-2.0-2.22.0-2.22.0-1.8-2.11.81.8-1.11.31.30.9
Locomotion in novel chamber post-restriction0.00.00.1-0.20.20.1-0.20.1-0.1-0.00.30.0-0.2-0.1-0.1-0.20.2
Fecal boli incidents, locomotor time 11.71.92.7-1.61.51.5-1.41.5-1.41.31.6-1.4-1.21.6-1.2-0.9-0.5
Change in fecal boli incidents, locomotor task1.61.52.81.3-0.8-1.11.1-1.21.4-1.0-1.10.71.5-1.71.61.5-0.4
Time >=10cm from walls, locomotor time 10.30.31.00.00.50.2-0.20.10.10.30.2-0.50.4-0.91.00.9-1.0
Bouts of movement, locomotor time 11.11.21.7-1.10.81.1-1.01.2-1.31.11.2-0.9-1.31.1-1.0-1.1-0.6
Total resting periods, locomotor time 12.02.23.2-1.71.21.4-1.41.5-1.71.41.6-1.1-1.81.8-1.6-1.6-0.5
Rest time, locomotor task time 11.41.52.5-1.31.01.4-1.31.6-1.41.50.8-1.1-1.60.5-1.1-1.1-0.7
Distance moved, locomotor task time 12.52.74.11.9-1.6-2.01.8-1.91.9-1.8-1.41.42.0-1.11.51.60.3
Vertical activity count, locomotor time 13.33.45.92.0-1.9-2.42.1-2.32.1-2.2-1.71.92.1-0.81.31.30.9
Time >=10cm from walls, locomotor time 20.50.61.3-0.71.00.9-0.80.7-0.60.90.8-1.0-0.4-0.30.10.2-1.1
Bouts of movement, locomotor time 23.53.85.8-2.31.92.0-2.01.9-2.21.91.9-1.8-2.41.7-2.0-1.9-0.4
Total resting periods, locomotor time 22.62.84.6-2.01.61.7-1.71.6-1.91.51.6-1.4-2.11.6-1.9-1.8-0.1
Rest time, locomotor task time 20.20.30.7-0.50.10.5-0.40.6-0.50.30.1-0.0-0.70.6-0.7-0.80.4
Distance moved, locomotor task time 21.31.52.51.4-0.9-1.41.2-1.31.3-1.0-0.80.71.5-1.41.51.6-0.5
Vertical activity count, locomotor time 21.61.84.51.3-0.4-1.11.0-1.11.3-0.6-0.60.21.7-2.02.02.1-1.1
Light reinforcement 10.51.02.4-1.21.41.1-1.11.0-1.01.11.6-1.1-0.80.4-0.5-0.20.1
Light reinforcement 20.20.30.7-0.70.80.6-0.60.4-0.50.60.7-0.8-0.20.2-0.3-0.1-0.1
Bone: marrow area2.24.87.92.6-2.1-2.42.5-2.42.5-2.3-2.61.72.8-1.91.61.7-0.1
Bone: maximum diameter0.81.52.41.5-1.1-1.31.3-1.31.4-1.1-1.50.91.6-1.31.11.1-0.1
Bone: maximum force0.61.01.41.1-1.0-1.21.2-1.21.2-1.1-1.11.10.8-0.70.60.40.7
Bone: maximum moment0.61.01.51.1-1.2-1.21.2-1.21.2-1.2-1.11.20.8-0.40.40.20.9
Mean time between licks in bursts0.00.00.1-0.0-0.1-0.20.1-0.20.1-0.20.00.10.30.1-0.00.2-0.0
Mean num. licks in bursts2.22.64.0-1.71.62.0-1.82.0-1.91.91.6-1.5-2.01.0-1.0-1.3-0.6
Cd content in liver1.31.42.7-1.01.61.4-1.31.4-1.11.61.3-1.5-1.0-0.20.20.2-1.2
Co content in liver0.30.40.60.8-0.6-0.50.7-0.50.8-0.4-0.60.50.7-0.50.70.70.1
Cu content in liver0.60.71.50.9-0.8-0.91.0-1.00.9-0.9-0.80.61.2-0.50.80.90.0
Fe content in liver0.50.61.3-0.80.50.6-0.70.6-0.80.30.7-0.1-1.00.9-1.1-1.10.9
K content in liver0.40.40.8-0.90.70.6-0.70.5-0.70.60.9-0.7-0.40.5-0.4-0.5-0.5
Mg content in liver0.70.71.4-1.20.80.8-0.90.7-1.00.61.1-0.7-0.60.9-0.8-0.8-0.2
Mn content in liver2.12.43.6-1.81.21.5-1.61.6-1.81.41.6-1.2-1.91.4-1.9-1.9-0.2
Na content in liver1.11.22.31.1-0.7-1.21.1-1.31.3-1.0-0.90.61.5-1.21.31.3-0.2
Rb content in liver0.20.31.70.1-0.4-0.30.3-0.40.2-0.6-0.20.80.00.4-0.4-0.31.3
Se content in liver2.32.85.6-1.32.41.8-1.81.8-1.52.11.8-2.4-1.0-0.80.30.3-2.2
Sr content in liver0.40.41.20.40.3-0.20.2-0.20.5-0.0-0.2-0.40.6-1.11.11.1-1.0
Zn content in liver0.30.31.6-0.7-0.10.2-0.30.2-0.5-0.00.40.1-0.31.3-0.9-0.80.5
Bone: minimum diameter1.42.64.02.0-1.8-1.81.9-1.81.9-1.9-2.01.61.8-1.20.50.70.6
Time in familiar zone, hab. session 10.10.10.80.10.20.1-0.00.10.10.20.0-0.40.4-0.50.40.5-0.9
Time in novel zone, hab. session 10.00.00.1-0.10.30.2-0.20.2-0.10.10.3-0.0-0.3-0.10.20.10.3
Total zone transitions, hab. session 11.21.73.11.5-1.5-1.41.5-1.41.4-1.5-1.51.81.0-0.50.50.41.6
Total locomotion distance, hab. session 10.71.01.71.3-0.8-1.01.0-1.01.1-0.9-1.01.10.8-1.10.80.90.8
Locomotion velocity, hab. session 10.81.11.71.3-1.0-1.11.1-1.11.1-1.0-1.11.30.8-0.80.50.61.1
Time in familiar zone, hab. session 23.94.05.9-2.22.32.4-2.42.4-2.32.42.3-2.1-2.20.9-0.9-1.0-0.7
Time in novel zone, hab. session 23.23.24.71.9-2.1-2.22.1-2.22.0-2.1-2.12.01.8-0.60.60.70.9
Total zone transitions, hab. session 22.73.55.02.2-1.6-2.02.0-2.02.2-1.8-2.01.52.1-1.92.01.90.2
Total locomotion distance, hab. session 21.41.82.71.7-1.0-1.41.4-1.41.5-1.1-1.41.11.4-1.61.61.60.2
Locomotion velocity, hab. session 21.82.54.21.9-1.0-1.51.5-1.51.8-1.2-1.51.01.7-2.02.02.0-0.0
Novel to familiar place preference ratio1.11.23.9-0.3-0.8-0.20.1-0.2-0.2-0.6-0.11.1-0.81.8-1.6-2.02.0
Novelty place preference1.51.55.0-0.4-0.8-0.10.1-0.1-0.3-0.6-0.11.1-0.92.0-1.9-2.22.2
Time in novel zone, NPP test1.61.75.6-0.1-1.2-0.50.4-0.5-0.0-1.0-0.41.5-0.71.9-1.9-2.22.4
Total zone transitions, NPP test1.11.65.91.10.1-0.60.6-0.61.1-0.2-0.6-0.21.4-2.12.42.4-1.1
Total locomotion distance, NPP test0.81.14.30.80.4-0.30.3-0.30.70.1-0.2-0.40.9-1.82.12.1-1.1
Locomotion velocity, NPP test0.81.14.30.40.80.1-0.10.10.30.60.2-0.80.7-1.82.12.1-1.3
Intraocular pressure0.60.91.6-1.11.21.1-1.11.0-1.00.91.3-1.0-0.90.5-0.3-0.4-0.2
Delta distance traveled before/after self-admin0.40.51.10.8-1.0-0.80.8-0.60.7-0.7-1.00.80.5-0.20.10.10.4
Delta ambulatory time before/after self-admin0.30.30.60.7-0.7-0.70.7-0.60.6-0.5-0.80.60.4-0.20.20.20.3
Parametrial fat weight0.61.12.51.1-0.7-1.21.1-1.11.1-0.9-0.80.41.6-1.01.31.5-0.3
Pavlov. Cond. lever latency0.81.02.6-1.00.30.8-0.70.8-0.90.30.9-0.1-1.31.5-1.5-1.61.0
Pavlov. Cond. magazine entry latency2.12.83.91.9-1.7-1.91.9-1.91.9-1.6-2.01.42.0-1.21.51.60.1
Pavlov. Cond. change in total contacts0.80.81.80.9-0.5-0.80.8-0.80.9-0.4-0.90.31.1-1.21.41.3-0.6
Pavlov. Cond. index score2.83.66.02.1-1.3-1.81.8-1.82.1-1.3-1.90.92.4-2.22.42.5-0.9
Pavlov. Cond. latency score2.32.95.61.8-1.0-1.61.5-1.61.8-1.0-1.70.62.2-2.22.32.4-1.1
Pavlov. Cond. lever contacts1.51.84.21.4-0.5-1.11.1-1.11.3-0.6-1.20.21.7-1.92.02.0-1.2
Pavlov. Cond. magazine entry number4.15.18.2-2.52.22.6-2.52.6-2.62.22.6-1.7-2.91.7-2.0-2.10.1
Pavlov. Cond. intertrial magazine entries0.91.01.7-1.11.01.1-1.21.1-1.21.01.1-0.9-1.30.6-0.9-1.0-0.2
Pavlov. Cond. lever-magazine prob. diff.2.73.45.62.0-1.3-1.81.8-1.82.0-1.4-2.00.92.4-2.12.22.3-0.8
Pavlov. Cond. response bias3.44.27.12.2-1.9-2.22.2-2.22.3-1.9-2.31.42.7-1.72.02.1-0.5
Pavlov. Cond. lever latency3.54.76.8-2.62.32.4-2.52.4-2.52.32.5-2.2-2.31.7-1.5-1.4-1.0
Pavlov. Cond. magazine entry latency1.82.14.41.2-2.1-1.51.6-1.51.3-1.7-1.71.90.90.7-0.7-0.71.7
Pavlov. Cond. change in total contacts3.65.07.52.7-2.3-2.42.6-2.42.6-2.3-2.52.32.3-1.91.61.61.1
Pavlov. Cond. index score5.36.79.73.0-3.1-2.93.1-2.93.0-2.9-3.12.92.7-1.31.21.11.5
Pavlov. Cond. latency score4.65.78.32.8-2.9-2.72.9-2.72.8-2.6-2.92.72.5-1.21.11.01.3
Pavlov. Cond. lever contacts4.05.57.72.8-2.4-2.62.7-2.62.7-2.4-2.62.32.6-2.01.81.60.9
Pavlov. Cond. magazine entry number4.55.59.6-2.53.12.7-2.82.7-2.52.72.8-2.9-2.10.3-0.2-0.2-2.0
Pavlov. Cond. intertrial magazine entries0.10.20.70.30.30.0-0.00.00.10.2-0.0-0.30.3-0.70.80.8-0.7
Pavlov. Cond. lever-magazine prob. diff.4.96.38.92.9-2.9-2.83.0-2.82.9-2.7-3.02.72.7-1.41.31.21.3
Pavlov. Cond. response bias3.85.27.22.6-2.6-2.62.7-2.62.6-2.6-2.62.62.3-1.41.11.01.5
Time in closed arm before self-admin0.91.01.6-1.21.01.0-1.11.2-1.21.20.7-1.0-1.30.8-0.9-0.9-0.1
Time in closed arm after self-admin0.40.40.9-0.50.90.6-0.70.7-0.50.90.6-1.0-0.2-0.20.40.5-0.8
Time in open arm before self-admin4.14.47.22.4-2.7-2.62.4-2.32.3-2.4-2.42.51.9-0.91.00.91.4
Time in open arm after self-admin0.60.71.40.8-1.1-0.80.9-1.10.8-1.2-0.91.20.6-0.2-0.1-0.11.0
Bone: periosteal estimation1.63.24.72.1-1.9-2.12.1-2.12.1-2.0-2.21.62.1-1.41.01.10.2
Bone: periosteal perimeter0.30.51.80.9-0.2-0.50.6-0.50.7-0.4-0.60.20.8-1.31.01.0-0.3
Bone: post-yield work0.40.61.20.8-0.5-0.70.7-0.70.9-0.3-0.80.20.9-0.91.10.9-0.7
Progressive ratio test 1 active lever presses1.21.25.50.70.3-0.20.3-0.30.8-0.1-0.3-0.41.2-2.31.81.8-1.3
Progressive ratio test 1 breakpoint1.31.36.00.70.3-0.10.2-0.20.8-0.0-0.3-0.51.2-2.51.91.9-1.4
Progressive ratio test 1 inactive lever presses0.80.92.1-0.21.20.5-0.50.3-0.10.50.7-1.20.5-1.31.31.3-1.5
Progressive ratio test 2 active lever presses1.51.64.4-0.51.51.0-1.01.3-0.61.60.9-1.8-0.1-1.51.21.2-2.1
Progressive ratio test 2 breakpoint1.31.54.5-0.21.30.7-0.81.0-0.41.40.6-1.60.2-1.71.51.5-2.1
Progressive ratio test 2 inactive lever presses1.41.63.5-1.11.81.2-1.31.6-1.11.61.2-1.9-0.8-0.60.30.3-1.6
Incentive Sensitization - Responses0.80.82.8-0.20.80.5-0.70.9-0.61.40.3-1.2-0.3-1.10.80.8-1.7
Incentive Sensitization - Breakpoint0.91.03.1-0.30.90.6-0.81.0-0.71.50.4-1.3-0.4-1.00.90.9-1.8
Sum of active levers in priming session hrs 5-60.50.51.3-0.10.80.4-0.40.3-0.10.60.5-0.90.3-1.01.01.0-1.2
Progressive ratio0.10.10.4-0.10.40.1-0.30.2-0.20.40.1-0.6-0.1-0.60.40.4-0.7
Food seeking constrained by brief footshock2.12.65.01.5-1.8-1.71.7-2.01.7-2.2-1.62.01.6-0.20.10.21.9
Seeking ratio, punishment vs. effort1.21.42.90.9-1.5-1.21.3-1.41.1-1.7-0.91.70.90.5-0.4-0.21.7
Retroperitoneal fat weight1.55.09.02.5-1.5-2.12.3-2.32.6-2.1-2.21.33.0-2.62.72.50.2
Reaction time number correct1.31.85.4-0.31.71.1-0.70.9-0.21.20.8-1.80.5-1.71.81.6-2.3
Reaction time mean minus median2.53.47.81.4-2.7-1.71.8-1.61.3-2.2-1.82.80.41.2-1.2-1.12.7
Reaction time mean minus median AUC1.72.25.21.2-2.2-1.41.5-1.31.1-1.7-1.52.30.30.9-0.9-0.82.2
Reaction time num false alarms0.10.10.2-0.20.20.3-0.20.3-0.30.10.3-0.1-0.50.0-0.4-0.40.5
Reaction time num false alarms AUC0.10.10.2-0.20.50.4-0.30.3-0.30.30.4-0.4-0.3-0.3-0.1-0.10.1
Reaction time trials correct on left1.31.85.4-0.31.71.1-0.70.9-0.21.20.8-1.80.5-1.71.81.6-2.3
Reaction time trials on left1.21.74.9-0.31.61.1-0.70.9-0.31.20.8-1.70.4-1.61.81.6-2.2
Reaction time mean1.52.17.70.7-1.9-1.11.0-1.10.6-1.5-1.02.1-0.21.6-1.5-1.52.8
Reaction time mean AUC1.62.28.50.5-1.8-0.90.9-0.90.4-1.4-0.92.1-0.41.8-1.7-1.72.9
Median of all reaction times1.01.36.10.1-1.1-0.50.4-0.50.1-1.0-0.31.4-0.51.6-1.5-1.52.5
Reaction time omissions2.22.912.4-0.2-1.6-0.60.6-0.4-0.1-1.2-0.61.9-0.92.7-2.5-2.53.5
Reaction time false alarm rate0.20.21.40.1-0.4-0.30.1-0.2-0.0-0.4-0.10.5-0.40.3-0.7-0.61.2
Reaction time premature initiation rate4.35.78.9-2.82.22.4-2.62.6-2.72.42.6-2.0-3.02.2-2.2-2.1-0.7
Reaction time premature initiations3.85.38.1-2.62.82.6-2.62.7-2.52.72.6-2.7-2.30.9-0.8-0.9-1.9
Std. dev. reaction times3.14.410.81.6-2.9-2.02.0-2.01.5-2.5-2.03.10.71.3-1.2-1.23.3
Reaction time trials completed1.21.74.9-0.31.61.1-0.70.9-0.31.20.8-1.70.4-1.61.81.6-2.2
Reaction time trials AUC1.11.64.7-0.31.61.0-0.70.8-0.21.10.7-1.70.4-1.71.81.6-2.2
Run reversals in cocaine runway, females0.50.51.00.8-0.3-0.50.7-0.70.8-0.6-0.60.30.9-1.00.80.8-0.4
Run reversals in cocaine runway, males0.90.91.41.1-0.8-1.00.9-1.01.1-0.9-0.90.71.2-0.91.20.90.0
Latency to leave start box in cocaine runway0.70.72.2-0.1-0.8-0.60.4-0.30.0-0.5-0.40.9-0.51.5-1.4-1.21.4
Latency to leave start box in cocaine runway, F0.70.72.9-0.5-0.3-0.1-0.10.4-0.50.30.00.2-1.11.7-1.5-1.50.7
Latency to leave start box in cocaine runway, M0.20.21.2-0.3-0.2-0.0-0.0-0.1-0.2-0.30.10.4-0.20.8-0.8-0.61.1
Std. dev. time between licks in bursts0.60.81.30.7-1.0-1.11.0-1.10.9-1.1-0.81.10.90.10.40.60.9
Total sessions with >9 infusions0.00.00.1-0.20.30.1-0.20.1-0.10.10.1-0.3-0.0-0.20.10.1-0.1
Short access day 1 total inactive lever presses0.50.61.80.60.2-0.40.2-0.40.50.1-0.4-0.40.8-1.31.31.3-1.0
Short access day 10 total inactive lever presses0.00.00.00.0-0.00.10.0-0.1-0.10.10.0-0.0-0.0-0.00.20.2-0.2
Short access day 1 total infusions0.30.31.20.20.50.1-0.00.00.10.30.1-0.60.4-1.10.80.8-0.7
Short access day 10 total infusions0.40.41.4-0.31.00.5-0.40.30.00.10.7-0.90.5-1.20.70.7-0.8
Short access total infusions1.01.12.4-0.51.50.8-0.80.9-0.41.01.1-1.60.1-1.31.11.1-1.4
Short access day 1 locomotion1.61.73.01.5-1.7-1.71.6-1.21.4-1.4-1.71.51.1-0.60.50.50.7
Short access day 10 total locomotion0.60.61.50.7-1.2-0.80.8-0.60.7-0.8-1.21.10.3-0.3-0.3-0.30.8
Short access total locomotion0.20.20.60.4-0.3-0.40.30.00.4-0.0-0.40.00.4-0.80.50.5-0.5
One hour access (0.3 mA shock)1.11.34.20.20.90.2-0.40.60.00.90.2-1.20.6-2.01.81.8-1.9
Compulsive drug intake4.74.76.82.6-2.3-2.52.4-2.42.4-2.2-2.22.12.5-1.42.02.00.5
One hour access (shock baseline)3.03.56.6-1.82.42.2-2.12.3-1.82.41.8-2.6-1.4-0.60.00.0-2.0
Social response proportion4.44.77.6-2.42.22.6-2.42.7-2.52.52.3-2.2-2.41.2-1.5-1.6-0.4
Social responses0.10.20.5-0.20.40.6-0.40.7-0.30.60.4-0.5-0.2-0.30.30.2-0.3
Social time5.77.511.5-3.42.82.9-3.12.8-3.12.63.2-2.4-3.22.3-2.3-2.4-0.2
Soleus weight1.23.69.41.2-2.7-1.81.8-1.81.3-2.3-1.82.80.41.5-1.1-1.13.1
Bone: stiffness0.50.71.31.1-0.6-1.00.9-1.01.0-0.8-0.80.70.9-1.10.90.60.1
Tibialis anterior weight6.622.530.65.5-5.0-5.45.5-5.45.5-5.3-5.54.85.1-3.03.03.12.0
Time to tail flick, vehicle, before self-admin0.70.72.1-0.7-0.0-0.0-0.20.1-0.4-0.30.40.4-0.71.4-1.5-1.41.4
Time to tail flick, vehicle, after self-admin2.12.24.0-1.51.91.6-1.71.7-1.51.91.7-2.0-1.10.3-0.1-0.1-1.7
Time to tail flick, test, before self-admin0.80.72.10.1-1.0-0.40.4-0.20.0-0.6-0.51.1-0.51.3-1.3-1.31.4
Time to tail flick, test, after self-admin0.60.62.2-0.1-0.6-0.00.10.1-0.2-0.3-0.30.8-0.70.8-1.4-1.31.5
Delta time to tail flick, vehicle, before/after SA3.73.77.1-1.72.42.3-2.12.1-1.82.52.0-2.7-1.3-0.10.20.2-2.5
Delta time to tail flick, test, before/after SA0.10.10.2-0.30.40.4-0.40.5-0.30.50.3-0.4-0.2-0.3-0.00.0-0.3
Tibia length1.13.011.1-1.02.11.2-1.31.2-0.81.91.4-2.60.2-1.31.71.7-3.3
Ambulatory time before self-admin0.50.51.10.7-0.4-0.80.6-0.50.7-0.4-0.50.30.9-0.81.11.0-0.4
Ambulatory time after self-admin1.21.32.01.4-1.1-1.31.2-1.11.2-0.9-1.40.91.3-1.01.21.20.0
Bone: tissue strength1.51.53.9-1.10.40.9-0.90.9-1.10.40.80.1-1.71.6-1.9-2.01.5
Total heroin consumption0.30.30.70.7-0.8-0.50.6-0.60.6-0.6-0.90.80.4-0.1-0.0-0.10.7
Bone: trabecular number0.10.10.60.0-0.3-0.10.2-0.10.1-0.3-0.20.4-0.30.4-0.4-0.60.8
Bone: trabecular spacing0.30.42.0-0.30.70.5-0.50.5-0.30.70.5-1.00.2-0.40.20.6-1.4
Bone: trabecular thickness0.10.10.7-0.5-0.2-0.0-0.0-0.0-0.1-0.00.0-0.1-0.40.8-0.5-0.7-0.1
Bone: trabecular tissue density1.92.74.5-2.11.51.8-1.91.8-2.01.61.8-1.3-2.01.7-1.2-1.3-0.1
Water consumed over 24 hours0.91.02.11.0-1.4-1.31.3-1.31.1-1.2-1.31.10.90.00.10.00.4
Number of responses in last shaping day0.30.30.60.8-0.6-0.70.7-0.60.7-0.5-0.60.40.5-0.30.40.40.0