Hub : Genes

Aldh3b1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Aldh3b1 0.4 0.18 6.0e-06 0.22 0.11 0.21 0.2 5.1e-06 1.3e-03 8.8e-06 2.0e-05
2 Brain mRNA stability Aldh3b1 0.06 0.04 6.6e-05 0.02 0.01 0.03 0.03 2.4e-03 2.2e-02 1.3e-03 9.9e-04
3 BLA gene expression Aldh3b1 0.1 0.07 7.0e-04 0.05 0.03 0.03 0.03 1.8e-03 1.2e-02 1.2e-02 8.5e-03
4 Adipose gene expression Aldh3b1 0.11 0.08 3.6e-05 0.02 0.03 0.04 0.03 4.8e-03 8.4e-04 8.8e-06 1.0e-04
5 PL gene expression Aldh3b1 0.06 0.04 1.2e-05 0.05 0.05 0.04 0.05 4.3e-06 6.0e-06 2.1e-05 7.1e-06
6 pVTA gene expression Aldh3b1 0.09 0.06 6.0e-06 0.07 0.06 0.05 0.06 3.7e-06 1.4e-05 8.7e-05 8.3e-06
7 Brain gene expression Aldh3b1 0.08 0.06 2.2e-07 0.07 0.04 0.06 0.07 5.2e-07 5.2e-05 1.1e-06 1.8e-07
8 Adipose mRNA stability Aldh3b1 0.16 0.1 8.4e-07 0.03 0.04 0.04 0.04 5.1e-04 1.3e-05 4.4e-05 9.9e-06
9 NAcc gene expression Aldh3b1 0.06 0.04 6.1e-10 0.04 0.06 0.07 0.06 3.9e-07 3.7e-10 2.9e-10 4.2e-10
10 NAcc mRNA stability Aldh3b1 0.05 0.03 4.9e-08 0.03 0.05 0.05 0.04 9.7e-05 3.4e-08 1.5e-07 2.0e-07
11 RMTg mRNA stability Aldh3b1 0.17 0.11 6.0e-04 0.04 0.06 0.07 0.06 3.9e-02 9.1e-03 7.5e-03 1.2e-02
12 BLA mRNA stability Aldh3b1 0.08 0.06 1.4e-03 0.08 0.05 0.06 0.07 3.9e-05 1.7e-03 6.8e-04 2.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.83.37.1-0.6-1.31.22.01.31.6-1.8-2.12.5-2.52.70.0
Area under the delay curve0.60.91.4-0.1-0.90.81.20.90.9-1.0-1.11.2-1.21.10.0
BMI with tail0.93.28.7-2.1-0.70.71.70.60.7-1.8-1.82.9-2.62.60.0
BMI without tail0.20.94.5-2.10.3-0.30.5-0.6-0.5-0.5-0.41.4-1.11.10.0
Body weight0.62.413.2-3.61.8-1.8-0.9-1.8-1.60.60.41.0-0.70.90.0
Weight adjusted by age0.30.81.5-1.21.2-1.2-1.1-1.0-1.10.80.6-0.40.4-0.40.0
Bone surface1.22.36.4-2.0-0.30.31.20.40.7-1.2-1.62.4-2.32.50.0
Bone volume1.12.25.4-0.9-0.90.91.51.01.2-1.5-1.72.2-2.12.30.0
Breakpoint value in progressive ratio session0.40.72.8-1.71.2-1.0-0.6-1.0-0.90.50.60.2-0.10.20.0
Number of licking bursts0.00.10.2-0.0-0.00.00.20.30.3-0.1-0.20.2-0.40.40.0
Context. condit. distance diff. score0.60.71.71.3-1.01.00.91.10.9-0.8-0.90.4-0.50.40.0
Locomotion velocity, session 10.00.00.10.0-0.00.0-0.10.10.3-0.1-0.10.0-0.10.20.0
Locomotion distance, session 10.91.22.8-0.6-0.60.61.00.71.1-1.1-1.21.5-1.51.70.0
Locomotion velocity, session 20.70.93.4-1.81.2-1.2-1.0-1.2-1.00.70.8-0.10.2-0.10.0
Locomotion distance, session 20.20.31.4-1.20.2-0.20.0-0.10.3-0.3-0.30.8-0.70.90.0
Locomotion velocity, session 31.51.72.9-0.1-1.21.21.41.31.4-1.5-1.41.7-1.61.70.0
Locomotion distance, session 30.10.20.30.1-0.30.30.30.40.5-0.5-0.40.4-0.40.50.0
Stereotopy head waving bouts, day 31.61.93.10.5-1.51.41.81.41.2-1.6-1.51.6-1.51.40.0
Stereotopy head waving duration, day 31.31.62.51.0-1.51.41.61.51.4-1.3-1.31.1-1.11.00.0
Locomotion velocity, session 70.91.01.80.0-0.90.91.20.90.7-1.2-1.11.4-1.21.20.0
Locomotion distance, session 70.10.10.3-0.60.1-0.00.1-0.10.0-0.2-0.20.5-0.40.50.0
Stereotopy head waving bouts, day 71.61.93.50.5-1.41.41.91.31.3-1.5-1.61.6-1.51.50.0
Stereotopy head waving duration, day 70.91.12.5-0.5-0.70.61.30.60.6-1.0-1.21.6-1.51.50.0
Locomotion velocity, session 80.40.51.7-1.31.0-1.0-0.7-0.9-0.90.60.40.00.00.10.0
Locomotion distance, session 80.40.61.40.6-0.80.80.80.91.2-0.8-0.90.7-0.70.80.0
Degree of sensitization distance0.10.20.5-0.5-0.10.10.40.00.1-0.3-0.40.7-0.60.60.0
Degree of sensitization stereotypy0.40.51.0-0.2-0.40.40.90.40.5-0.6-0.91.0-0.91.00.0
Conditioned locomotion3.54.16.3-1.72.4-2.4-2.5-2.3-2.12.22.2-1.91.8-1.70.0
Cocaine response after cond. corrected0.10.10.20.3-0.50.50.50.30.4-0.4-0.30.4-0.20.20.0
Cocaine response after cond. not corrected0.30.50.80.3-0.80.80.90.60.7-0.8-0.70.8-0.70.60.0
Cocaine response before conditioning0.00.10.2-0.1-0.10.10.30.20.2-0.1-0.30.3-0.40.40.0
Saline control response0.91.24.3-2.11.5-1.5-0.9-1.3-1.51.00.6-0.00.00.00.0
Bone: connectivity density1.52.46.6-1.8-0.50.41.40.50.8-1.3-1.72.4-2.42.60.0
Bone: cortical apparent density0.50.81.2-0.71.0-0.9-1.1-1.0-1.00.91.0-0.80.8-0.80.0
Bone: cortical area0.71.21.8-1.01.4-1.3-1.4-1.2-1.01.31.1-1.10.9-0.80.0
Bone: cortical porosity0.00.00.1-0.1-0.10.00.20.10.2-0.1-0.10.2-0.20.30.0
Bone: cortical porosity0.10.10.3-0.60.4-0.4-0.2-0.4-0.20.30.2-0.0-0.00.10.0
Bone: cortical thickness5.18.613.0-2.93.6-3.5-3.6-3.4-3.03.23.0-2.52.4-2.10.0
Bone: cortical thickness1.62.03.1-1.71.8-1.7-1.7-1.7-1.41.51.3-1.10.9-0.80.0
Bone: cortical tissue density0.61.01.6-0.91.1-1.1-1.2-1.1-1.21.01.1-0.90.9-0.80.0
Condit. Reinf. active minus inactive responses0.30.30.6-0.2-0.40.40.50.40.4-0.6-0.60.8-0.70.70.0
Condit. Reinf. active-inactive response ratio0.30.30.50.1-0.60.60.60.50.4-0.7-0.60.7-0.60.50.0
Condit. Reinf. active responses0.00.00.1-0.0-0.20.20.10.20.2-0.3-0.20.3-0.30.20.0
Condit. Reinf. inactive responses0.00.00.10.3-0.10.1-0.10.00.00.10.2-0.20.2-0.30.0
Incentive salience index mean0.10.20.4-0.3-0.20.20.20.20.3-0.4-0.50.6-0.60.60.0
Condit. Reinf. lever presses0.00.10.2-0.20.3-0.3-0.5-0.3-0.00.30.2-0.30.2-0.00.0
Condit. Reinf. active minus inactive responses1.42.13.00.8-1.61.61.71.51.7-1.7-1.51.5-1.51.50.0
Condit. Reinf. active-inactive response ratio1.32.13.91.5-1.81.81.61.72.0-1.5-1.41.0-1.11.10.0
Condit. Reinf. active responses1.52.13.30.1-1.41.41.71.31.4-1.7-1.61.8-1.71.70.0
Condit. Reinf. inactive responses0.30.51.4-1.1-0.10.10.50.1-0.1-0.6-0.71.2-1.01.00.0
Condit. Reinf. lever presses0.50.71.8-0.8-0.30.30.80.40.5-0.7-0.91.3-1.21.30.0
Condit. Reinf. lever reinforcers received1.42.03.5-0.1-1.31.21.61.21.3-1.6-1.61.9-1.71.80.0
Conditioned reinforcement - actives0.10.51.40.60.4-0.2-0.6-0.5-0.80.70.8-0.91.0-1.20.0
Conditioned reinforcement - inactives0.71.94.42.1-1.92.11.51.61.5-1.4-1.00.5-0.50.40.0
Conditioned locomotion1.82.712.93.6-2.12.01.11.91.9-1.0-0.6-0.80.4-0.60.0
Patch foraging indifference point 0 sec0.10.31.00.7-0.90.71.00.50.3-0.6-0.50.3-0.30.10.0
Patch foraging indifference point AUC0.71.62.8-1.21.7-1.4-1.5-1.3-1.51.41.3-1.11.0-1.00.0
Delay disc. indifference point, 0s delay1.92.13.70.0-1.51.31.91.41.3-1.6-1.71.7-1.71.70.0
Delay disc. indifference point, 16s delay0.50.71.31.1-1.10.91.11.21.1-0.8-0.90.4-0.50.40.0
Delay disc. indifference point, 2s delay0.91.01.50.7-1.11.01.21.21.2-1.0-1.10.9-1.01.00.0
Delay disc. indifference point, 24s delay0.20.40.7-0.40.6-0.6-0.8-0.6-0.60.60.8-0.60.6-0.60.0
Delay disc. indifference point, 4s delay0.30.40.7-0.2-0.40.20.80.60.6-0.6-0.80.7-0.80.80.0
Delay disc. indifference point, 8s delay0.20.30.7-0.4-0.50.50.70.30.3-0.6-0.50.8-0.70.60.0
Indifference point function ln k0.61.97.02.6-1.91.81.31.51.6-1.1-0.80.1-0.1-0.10.0
Indifference point function log k0.61.97.02.6-1.91.81.31.51.6-1.1-0.80.1-0.1-0.10.0
Patch foraging total patch changes 0 sec0.00.10.20.4-0.20.10.3-0.1-0.40.10.1-0.30.3-0.50.0
Patch foraging total patch changes 12 sec0.91.33.9-2.01.6-1.4-0.9-1.3-1.51.00.8-0.30.3-0.30.0
Patch foraging total patch changes 18 sec0.00.10.4-0.60.2-0.3-0.0-0.1-0.60.0-0.00.2-0.20.00.0
Patch foraging total patch changes 24 sec0.31.02.0-1.11.3-1.2-1.1-1.1-1.41.01.0-0.70.7-0.80.0
Patch foraging total patch changes 6 sec0.20.31.5-1.20.2-0.20.4-0.1-0.5-0.2-0.30.7-0.70.60.0
Patch foraging time to switch 0 sec0.51.84.3-1.3-0.50.51.10.80.8-1.2-1.62.1-2.02.10.0
Patch foraging water rate 0 sec0.62.26.12.50.10.0-0.8-0.2-0.11.11.4-2.42.2-2.30.0
Patch foraging water rate 12 sec0.62.410.03.2-0.40.4-0.80.30.70.81.2-2.42.2-2.10.0
Patch foraging water rate 18 sec0.20.42.21.5-0.40.4-0.10.31.00.20.2-0.70.7-0.50.0
Patch foraging water rate 24 sec1.01.44.01.60.2-0.2-1.0-0.50.11.01.3-2.01.9-1.70.0
Patch foraging water rate 6 sec1.11.64.01.50.6-0.5-1.2-0.6-0.51.21.4-2.01.9-1.80.0
Seeking ratio, delayed vs. immediate footshock0.60.81.7-0.2-0.80.81.21.00.6-1.0-1.01.3-1.21.00.0
Distance traveled before self-admin0.10.30.6-0.1-0.20.20.60.40.5-0.5-0.70.7-0.80.80.0
Distance traveled after self-admin0.00.00.0-0.2-0.10.00.10.00.1-0.2-0.20.1-0.20.20.0
Extensor digitorum longus weight3.313.132.4-5.74.6-4.6-4.1-4.6-4.33.23.1-1.41.6-1.30.0
Bone: elastic displacement2.22.84.90.01.5-1.5-2.0-1.6-1.41.81.9-2.22.1-2.10.0
Bone: elastic work2.53.25.1-1.72.2-2.1-2.3-2.1-1.92.01.8-1.51.5-1.30.0
Bone: endosteal estimation1.74.15.81.8-2.42.32.42.42.3-2.1-2.11.7-1.71.70.0
Bone: endosteal perimeter3.48.312.62.7-3.43.43.63.43.1-3.1-3.02.5-2.42.30.0
Epididymis fat weight0.94.415.74.0-2.82.71.82.82.6-1.5-1.3-0.0-0.1-0.00.0
Delta time in closed arm before/after self-admin1.21.12.0-1.21.4-1.2-1.2-1.3-1.21.11.0-0.60.7-0.60.0
Delta time in open arm before/after self-admin0.40.40.80.1-0.70.60.80.40.9-0.8-0.70.7-0.70.80.0
Diff in mean of infusions in LGA sessions0.30.51.2-0.81.0-1.1-0.7-0.8-0.90.80.7-0.40.4-0.30.0
Delay discount exponential model param0.40.61.00.20.7-0.6-0.9-0.7-0.70.80.9-0.91.0-1.00.0
Extinction: sum of active levers before priming0.30.42.1-1.50.6-0.40.1-0.4-0.2-0.0-0.20.9-0.80.90.0
Active lever presses in extinction session 61.01.01.7-1.21.3-1.2-1.3-1.2-1.10.81.1-0.60.7-0.60.0
Bone: final force0.30.42.3-1.50.8-0.8-0.5-0.6-0.40.40.10.3-0.30.50.0
Bone: final moment0.30.42.2-1.50.8-0.8-0.6-0.7-0.50.40.20.3-0.30.40.0
Food consumed during 24 hour testing period0.10.10.40.60.1-0.1-0.20.00.20.40.3-0.70.5-0.50.0
Glucose3.65.87.91.8-2.72.72.82.82.8-2.6-2.62.2-2.22.20.0
Heart weight1.72.84.50.5-1.71.72.11.81.5-1.8-1.91.9-1.91.80.0
Delay discount hyperbolic model param0.50.71.10.10.7-0.6-1.0-0.8-0.90.91.0-1.01.1-1.00.0
Intermittent access intake day 1-15 change0.21.15.62.4-1.21.00.61.31.3-0.4-0.6-0.50.2-0.30.0
Intermittent access intake escalation0.20.84.82.2-1.00.80.51.21.1-0.3-0.4-0.60.3-0.40.0
Intermittent access intake escalation 20.50.83.81.9-1.11.00.51.21.2-0.4-0.6-0.30.1-0.10.0
Intermitt. access day 1 inactive lever presses0.00.00.10.1-0.30.20.3-0.1-0.1-0.20.10.20.0-0.10.0
Intermitt. access day 15 inactive lever presses0.42.34.31.3-2.12.11.71.81.6-1.7-1.41.2-1.11.00.0
Intermitt. access escalation Index0.20.63.61.9-0.50.40.10.70.50.20.1-1.00.8-0.90.0
Intermittent access day 1 total infusions2.06.010.11.2-3.13.22.82.62.5-2.9-2.52.5-2.32.10.0
Intermittent access day 15 total infusions1.94.89.12.9-3.03.02.32.72.5-2.2-1.91.1-1.10.90.0
Intermittent access terminal intake (last 3 days)3.15.510.12.5-3.23.22.62.82.6-2.6-2.21.5-1.61.30.0
Intermittent access total infusions3.54.17.41.8-2.72.72.32.42.2-2.3-2.01.6-1.61.40.0
Intermittent access day 1 locomotion1.42.64.60.9-2.12.21.91.61.7-2.0-1.51.6-1.41.30.0
Intermittent access day 15 total locomotion1.14.48.02.8-2.72.72.12.72.6-2.1-1.90.9-1.21.00.0
Intermittent access total locomotion5.86.911.83.1-3.43.42.83.33.3-2.7-2.51.5-1.71.50.0
Intermittent access standard deviation0.10.71.41.2-1.21.10.81.11.1-0.8-0.80.3-0.50.40.0
Left kidney weight0.21.95.52.3-1.71.71.41.81.8-1.0-1.10.2-0.40.40.0
Right kidney weight0.10.63.51.9-0.80.80.40.91.0-0.1-0.1-0.60.4-0.40.0
Cocaine induced anxiety0.10.10.30.2-0.30.30.40.30.5-0.4-0.40.4-0.40.50.0
Post-drug Anxiety0.10.10.5-0.70.2-0.2-0.0-0.3-0.20.0-0.00.3-0.20.30.0
Baseline Anxiety0.20.41.0-0.80.7-0.7-0.6-0.8-1.00.60.6-0.20.4-0.40.0
Tail length0.84.06.0-1.82.4-2.4-2.1-2.5-2.42.22.2-1.61.7-1.60.0
Length with tail1.67.212.1-3.23.5-3.4-3.1-3.3-3.22.82.5-1.61.6-1.40.0
Length without tail0.84.37.7-2.82.7-2.7-2.6-2.5-2.42.11.8-1.11.1-0.90.0
Times rat made contact with spout0.30.30.9-0.7-0.10.00.50.10.2-0.4-0.60.9-0.80.90.0
Lifetime Intake2.12.65.21.3-2.22.31.91.81.6-2.0-1.51.4-1.21.00.0
Liver weight, left0.20.30.90.80.2-0.2-0.4-0.1-0.30.60.6-0.90.9-0.90.0
Liver weight, right0.20.31.91.4-0.40.40.10.40.50.20.2-0.70.6-0.70.0
Locomotor activity0.20.21.01.0-0.30.2-0.20.20.60.20.3-0.70.6-0.50.0
Locomotor testing distance0.10.31.21.1-0.30.2-0.30.30.40.20.4-0.80.7-0.60.0
Locomotor testing rearing0.31.02.01.2-1.11.21.01.21.4-0.9-0.90.6-0.60.70.0
Locomotion in novel chamber3.14.28.32.9-2.82.72.12.62.6-1.9-1.70.7-0.90.80.0
Locomotion in novel chamber post-restriction0.72.05.92.4-1.81.71.51.71.9-1.2-1.10.2-0.40.40.0
Fecal boli incidents, locomotor time 10.00.00.10.3-0.30.20.40.00.2-0.2-0.10.10.0-0.10.0
Change in fecal boli incidents, locomotor task0.00.00.1-0.30.00.00.1-0.1-0.0-0.2-0.10.3-0.20.20.0
Time >=10cm from walls, locomotor time 13.13.96.11.3-2.52.42.32.02.2-2.4-2.21.8-1.71.70.0
Bouts of movement, locomotor time 11.31.72.7-0.91.6-1.6-1.5-1.4-1.41.51.3-1.31.1-1.00.0
Total resting periods, locomotor time 11.01.11.7-0.51.3-1.3-1.3-1.1-1.11.31.0-1.21.0-1.00.0
Rest time, locomotor task time 10.30.52.11.4-0.50.50.10.50.30.10.2-0.90.8-1.00.0
Distance moved, locomotor task time 10.41.02.0-0.3-0.80.81.10.81.0-1.1-1.11.4-1.31.40.0
Vertical activity count, locomotor time 10.21.21.90.9-1.31.41.41.31.3-1.1-1.11.0-0.90.90.0
Time >=10cm from walls, locomotor time 20.00.10.30.4-0.00.0-0.2-0.1-0.00.10.2-0.50.5-0.50.0
Bouts of movement, locomotor time 20.10.30.9-0.80.7-0.8-0.3-0.9-0.60.50.5-0.20.3-0.20.0
Total resting periods, locomotor time 20.00.10.3-0.40.4-0.50.1-0.5-0.20.20.20.10.00.00.0
Rest time, locomotor task time 21.32.24.01.5-2.01.91.81.81.7-1.6-1.41.0-1.00.90.0
Distance moved, locomotor task time 21.11.42.2-1.11.5-1.3-1.4-1.4-1.31.31.2-1.01.0-1.00.0
Vertical activity count, locomotor time 21.12.63.5-0.31.6-1.5-1.8-1.7-1.61.81.8-1.91.9-1.90.0
Light reinforcement 10.00.21.11.0-0.20.3-0.00.5-0.00.20.1-0.50.4-0.60.0
Light reinforcement 20.30.63.61.9-0.80.90.20.80.8-0.2-0.1-0.60.5-0.60.0
Bone: marrow area1.74.26.01.8-2.42.42.52.42.3-2.2-2.21.8-1.81.70.0
Bone: maximum diameter0.00.00.20.5-0.10.00.00.20.20.20.0-0.30.2-0.20.0
Bone: maximum force0.61.33.4-1.5-0.20.20.80.30.5-0.9-1.11.8-1.71.90.0
Bone: maximum moment0.51.02.9-1.5-0.10.10.60.20.5-0.8-1.01.7-1.51.70.0
Mean time between licks in bursts0.10.30.8-0.90.7-0.7-0.6-0.7-0.80.50.5-0.20.2-0.20.0
Mean num. licks in bursts0.00.10.3-0.1-0.30.30.40.00.1-0.4-0.30.5-0.30.30.0
Cd content in liver0.90.92.81.7-1.31.21.01.21.2-0.9-0.80.2-0.30.20.0
Co content in liver1.31.53.40.50.8-0.8-1.5-0.8-0.91.21.4-1.81.7-1.70.0
Cu content in liver0.00.00.00.1-0.10.1-0.10.1-0.0-0.10.1-0.10.1-0.20.0
Fe content in liver0.10.10.3-0.50.4-0.4-0.4-0.4-0.20.20.3-0.20.2-0.10.0
K content in liver0.20.20.4-0.6-0.00.00.20.10.2-0.3-0.40.6-0.60.70.0
Mg content in liver0.60.61.00.6-0.90.91.01.00.8-0.9-0.80.7-0.70.60.0
Mn content in liver0.70.82.6-1.61.1-1.1-0.8-1.1-1.20.60.6-0.10.1-0.10.0
Na content in liver0.60.71.30.10.8-0.8-1.0-0.7-0.71.01.0-1.11.0-1.00.0
Rb content in liver1.72.02.91.2-1.71.71.61.71.6-1.6-1.41.3-1.21.20.0
Se content in liver0.60.70.90.5-1.00.91.00.90.8-1.0-0.90.9-0.80.80.0
Sr content in liver2.32.03.4-1.41.7-1.6-1.8-1.7-1.61.51.4-1.21.2-1.10.0
Zn content in liver0.60.71.0-0.70.9-0.9-1.0-0.9-1.00.80.8-0.70.7-0.80.0
Bone: minimum diameter2.34.36.21.3-2.22.22.52.22.5-2.2-2.32.1-2.02.20.0
Time in familiar zone, hab. session 10.60.60.90.9-0.90.90.90.90.9-0.9-0.80.7-0.60.60.0
Time in novel zone, hab. session 10.10.10.2-0.30.4-0.4-0.3-0.3-0.40.50.4-0.30.3-0.30.0
Total zone transitions, hab. session 10.10.10.7-0.90.4-0.4-0.2-0.3-0.10.1-0.10.4-0.30.40.0
Total locomotion distance, hab. session 10.30.51.00.7-0.90.80.70.81.0-0.6-0.60.5-0.40.50.0
Locomotion velocity, hab. session 10.10.10.40.3-0.40.40.30.40.6-0.3-0.30.2-0.20.20.0
Time in familiar zone, hab. session 20.91.01.6-0.51.2-1.2-1.2-1.1-1.01.21.0-1.00.9-0.80.0
Time in novel zone, hab. session 21.01.11.90.1-1.11.11.41.00.9-1.2-1.21.4-1.21.10.0
Total zone transitions, hab. session 22.12.66.5-1.1-1.01.01.71.01.1-1.7-1.82.6-2.32.40.0
Total locomotion distance, hab. session 21.21.62.90.0-1.21.21.51.11.2-1.4-1.41.7-1.61.60.0
Locomotion velocity, hab. session 21.41.82.70.3-1.41.41.61.31.4-1.5-1.51.7-1.51.50.0
Novel to familiar place preference ratio0.20.30.8-0.4-0.40.40.70.50.1-0.5-0.60.9-0.80.60.0
Novelty place preference0.30.40.9-0.1-0.60.60.90.70.3-0.7-0.80.9-0.90.70.0
Time in novel zone, NPP test0.40.50.9-0.1-0.60.60.90.70.3-0.7-0.81.0-0.90.70.0
Total zone transitions, NPP test0.40.51.6-1.10.00.00.40.10.4-0.6-0.71.1-1.11.30.0
Total locomotion distance, NPP test0.40.51.00.1-0.70.70.60.71.0-0.9-0.80.8-0.80.90.0
Locomotion velocity, NPP test0.20.30.80.1-0.50.50.40.60.9-0.7-0.60.6-0.60.70.0
Intraocular pressure0.40.71.70.70.4-0.4-0.7-0.5-0.40.91.0-1.31.3-1.30.0
Delta distance traveled before/after self-admin0.20.20.3-0.20.3-0.4-0.5-0.5-0.40.40.5-0.50.5-0.40.0
Delta ambulatory time before/after self-admin0.20.30.5-0.40.3-0.4-0.7-0.7-0.60.50.7-0.50.7-0.60.0
Parametrial fat weight1.94.48.73.0-2.62.62.32.62.8-1.9-2.00.9-1.21.20.0
Pavlov. Cond. lever latency0.10.10.30.5-0.30.30.20.20.2-0.10.1-0.20.2-0.30.0
Pavlov. Cond. magazine entry latency0.91.21.80.4-1.01.01.31.11.0-1.1-1.31.3-1.21.30.0
Pavlov. Cond. change in total contacts0.70.81.20.8-1.00.91.11.00.9-0.9-1.10.8-0.80.80.0
Pavlov. Cond. index score0.00.10.10.4-0.10.10.20.30.3-0.1-0.40.1-0.20.30.0
Pavlov. Cond. latency score0.10.10.30.2-0.20.20.30.40.4-0.3-0.50.3-0.40.50.0
Pavlov. Cond. lever contacts0.00.00.1-0.10.1-0.1-0.00.10.1-0.1-0.30.2-0.30.40.0
Pavlov. Cond. magazine entry number0.00.00.2-0.50.1-0.1-0.3-0.2-0.2-0.00.30.00.0-0.10.0
Pavlov. Cond. intertrial magazine entries0.40.41.10.30.4-0.4-0.6-0.5-0.60.70.8-1.01.0-1.00.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.3-0.10.10.30.30.4-0.1-0.40.1-0.20.40.0
Pavlov. Cond. response bias0.00.00.10.40.0-0.00.10.10.00.2-0.1-0.20.1-0.00.0
Pavlov. Cond. lever latency0.00.00.10.0-0.30.30.10.1-0.0-0.3-0.10.2-0.1-0.00.0
Pavlov. Cond. magazine entry latency0.60.93.7-1.90.4-0.40.3-0.3-0.0-0.3-0.61.4-1.31.40.0
Pavlov. Cond. change in total contacts0.20.61.4-0.3-0.50.50.90.60.7-0.7-0.91.0-1.11.20.0
Pavlov. Cond. index score0.20.31.0-0.90.1-0.10.40.10.2-0.2-0.50.9-0.91.00.0
Pavlov. Cond. latency score0.10.20.7-0.70.1-0.10.30.00.2-0.2-0.40.7-0.70.80.0
Pavlov. Cond. lever contacts0.00.00.1-0.10.2-0.2-0.00.00.10.20.0-0.1-0.10.20.0
Pavlov. Cond. magazine entry number0.81.04.72.2-0.50.5-0.20.50.20.30.5-1.51.3-1.50.0
Pavlov. Cond. intertrial magazine entries0.20.31.81.4-0.70.70.20.70.3-0.2-0.1-0.40.4-0.60.0
Pavlov. Cond. lever-magazine prob. diff.0.20.41.2-1.10.2-0.20.3-0.10.1-0.2-0.50.9-0.91.00.0
Pavlov. Cond. response bias0.20.31.1-0.90.1-0.10.30.00.3-0.2-0.50.8-0.91.00.0
Time in closed arm before self-admin0.91.53.01.1-1.71.41.41.31.5-1.5-1.20.9-1.00.90.0
Time in closed arm after self-admin0.00.00.10.2-0.10.0-0.1-0.10.00.10.2-0.20.2-0.20.0
Time in open arm before self-admin1.21.52.8-0.91.7-1.5-1.3-1.2-1.61.51.2-1.01.0-1.10.0
Time in open arm after self-admin0.10.10.7-0.80.5-0.5-0.1-0.4-0.40.20.00.2-0.20.20.0
Bone: periosteal estimation0.10.30.50.5-0.60.60.60.70.7-0.4-0.60.3-0.40.50.0
Bone: periosteal perimeter0.51.01.50.5-1.01.01.21.11.0-1.0-1.11.1-1.11.10.0
Bone: post-yield work6.711.618.50.6-3.33.24.03.23.2-3.8-3.94.3-4.04.00.0
Progressive ratio test 1 active lever presses0.00.10.20.0-0.30.50.0-0.2-0.5-0.20.30.00.2-0.40.0
Progressive ratio test 1 breakpoint0.00.10.2-0.0-0.20.4-0.0-0.2-0.5-0.20.3-0.00.3-0.40.0
Progressive ratio test 1 inactive lever presses0.00.10.20.1-0.40.50.2-0.1-0.4-0.40.10.20.1-0.20.0
Progressive ratio test 2 active lever presses1.01.43.51.5-1.71.91.31.31.1-1.3-0.90.7-0.50.30.0
Progressive ratio test 2 breakpoint0.91.23.11.4-1.51.81.21.21.0-1.2-0.80.6-0.40.30.0
Progressive ratio test 2 inactive lever presses1.65.211.13.1-3.23.32.42.82.5-2.3-1.81.0-1.00.70.0
Incentive Sensitization - Responses0.30.81.20.1-0.91.00.90.80.8-1.1-1.01.1-1.01.00.0
Incentive Sensitization - Breakpoint0.40.91.30.3-1.11.11.00.90.9-1.2-1.11.0-1.01.00.0
Sum of active levers in priming session hrs 5-63.53.35.4-0.11.8-1.5-2.2-1.6-1.52.12.1-2.32.2-2.20.0
Progressive ratio1.13.27.3-1.0-1.31.22.11.21.1-1.9-2.02.7-2.52.60.0
Food seeking constrained by brief footshock0.10.10.2-0.40.0-0.00.40.0-0.4-0.1-0.30.5-0.40.30.0
Seeking ratio, punishment vs. effort0.71.63.70.90.8-0.7-1.2-0.7-0.91.41.3-1.91.8-1.90.0
Retroperitoneal fat weight2.812.540.26.3-4.54.43.84.74.3-2.6-2.60.4-0.80.50.0
Reaction time number correct0.31.12.2-0.61.3-1.2-1.5-1.2-0.81.21.2-1.01.0-0.80.0
Reaction time mean minus median0.10.52.9-1.70.2-0.60.2-0.9-0.4-0.3-0.00.8-0.60.70.0
Reaction time mean minus median AUC0.10.62.6-1.60.8-1.1-0.5-1.3-0.70.40.60.00.10.10.0
Reaction time num false alarms0.71.22.1-0.21.1-1.1-1.2-1.2-1.11.21.2-1.41.3-1.30.0
Reaction time num false alarms AUC0.61.52.3-0.91.3-1.5-1.3-1.5-1.41.31.3-1.21.1-1.10.0
Reaction time trials correct on left0.31.12.2-0.61.3-1.2-1.5-1.2-0.81.21.2-1.01.0-0.80.0
Reaction time trials on left0.41.32.6-0.71.4-1.4-1.6-1.4-0.91.31.3-1.11.1-0.90.0
Reaction time mean0.20.51.0-0.0-0.90.61.00.70.6-0.9-0.70.9-0.80.80.0
Reaction time mean AUC0.30.71.30.1-1.00.71.10.80.8-1.0-0.91.0-0.90.90.0
Median of all reaction times0.71.01.70.5-1.21.01.31.21.0-1.1-1.11.0-1.00.90.0
Reaction time omissions0.50.93.6-1.91.0-1.3-0.9-1.4-1.00.50.6-0.00.10.00.0
Reaction time false alarm rate0.30.50.9-0.40.6-0.7-0.6-0.8-0.90.70.7-0.80.7-0.80.0
Reaction time premature initiation rate0.91.45.3-2.31.4-1.5-1.1-1.6-1.40.80.9-0.10.2-0.10.0
Reaction time premature initiations1.13.37.2-2.72.2-2.3-2.1-2.5-2.01.61.7-0.81.0-0.70.0
Std. dev. reaction times0.10.20.8-0.9-0.3-0.20.5-0.30.0-0.5-0.20.7-0.60.70.0
Reaction time trials completed0.41.32.6-0.71.4-1.4-1.6-1.4-0.91.31.3-1.11.1-0.90.0
Reaction time trials AUC0.31.02.1-0.61.2-1.2-1.4-1.2-0.81.11.1-1.01.0-0.70.0
Run reversals in cocaine runway, females0.40.51.3-0.9-0.40.30.30.20.6-0.8-0.71.0-1.01.20.0
Run reversals in cocaine runway, males0.80.81.2-0.30.9-0.9-1.1-1.0-0.81.11.0-1.11.1-1.00.0
Latency to leave start box in cocaine runway1.11.52.00.3-1.21.21.41.41.3-1.3-1.41.3-1.41.40.0
Latency to leave start box in cocaine runway, F0.91.11.80.2-0.90.91.11.11.3-1.0-1.31.1-1.31.30.0
Latency to leave start box in cocaine runway, M0.10.00.1-0.1-0.20.20.30.30.0-0.3-0.20.4-0.30.20.0
Std. dev. time between licks in bursts1.22.33.7-0.91.7-1.7-1.9-1.6-1.31.71.7-1.71.5-1.30.0
Total sessions with >9 infusions0.20.20.5-0.4-0.50.60.40.1-0.1-0.7-0.20.7-0.40.30.0
Short access day 1 total inactive lever presses0.40.92.11.4-1.41.41.01.11.0-0.9-0.60.3-0.20.10.0
Short access day 10 total inactive lever presses0.00.00.1-0.0-0.20.20.20.10.1-0.2-0.10.3-0.20.20.0
Short access day 1 total infusions0.61.12.71.0-1.61.61.21.20.9-1.3-0.80.8-0.60.40.0
Short access day 10 total infusions1.62.74.70.1-1.92.01.91.51.2-2.2-1.72.0-1.81.60.0
Short access total infusions0.71.02.00.0-1.31.41.20.80.5-1.4-0.91.3-1.00.80.0
Short access day 1 locomotion0.50.91.81.0-1.31.31.11.01.0-1.1-0.80.6-0.50.40.0
Short access day 10 total locomotion0.41.42.50.8-1.61.51.41.31.2-1.5-1.21.0-1.00.90.0
Short access total locomotion0.91.32.71.0-1.61.61.41.21.1-1.5-1.00.9-0.80.70.0
One hour access (0.3 mA shock)2.63.16.72.4-2.52.61.92.11.9-1.8-1.40.8-0.80.60.0
Compulsive drug intake2.23.35.8-1.92.3-2.1-1.8-2.4-2.21.91.9-1.11.4-1.30.0
One hour access (shock baseline)1.84.69.73.1-3.03.02.32.72.4-2.1-1.70.8-0.90.70.0
Social response proportion0.20.20.8-0.7-0.2-0.00.2-0.10.5-0.5-0.40.6-0.70.90.0
Social responses0.40.51.0-0.70.8-0.9-1.0-1.0-0.60.60.6-0.60.5-0.30.0
Social time0.20.30.8-0.90.7-0.7-0.5-0.7-0.60.30.2-0.00.1-0.00.0
Soleus weight0.82.213.03.6-1.41.50.51.51.4-0.2-0.0-1.41.2-1.30.0
Bone: stiffness0.81.53.7-1.0-0.60.61.20.70.9-1.1-1.41.9-1.81.90.0
Tibialis anterior weight6.823.634.9-5.85.9-5.9-5.8-5.8-5.84.84.7-3.33.4-3.20.0
Time to tail flick, vehicle, before self-admin0.91.22.4-0.4-0.80.41.30.91.0-1.0-1.31.4-1.51.50.0
Time to tail flick, vehicle, after self-admin0.40.82.5-1.3-0.10.20.70.10.2-0.8-0.91.6-1.31.40.0
Time to tail flick, test, before self-admin2.52.94.10.8-1.81.82.01.71.8-1.9-2.01.8-1.71.70.0
Time to tail flick, test, after self-admin0.10.10.40.10.2-0.6-0.3-0.1-0.60.30.1-0.30.3-0.40.0
Delta time to tail flick, vehicle, before/after SA0.10.20.8-0.90.5-0.1-0.3-0.4-0.50.0-0.10.4-0.20.30.0
Delta time to tail flick, test, before/after SA4.35.37.7-0.82.3-2.6-2.6-2.3-2.82.52.6-2.42.4-2.60.0
Tibia length0.82.13.3-0.61.5-1.5-1.8-1.6-1.11.71.7-1.81.6-1.50.0
Ambulatory time before self-admin0.20.61.3-0.0-0.50.40.90.70.9-0.7-1.00.9-1.11.10.0
Ambulatory time after self-admin0.91.42.10.8-1.41.31.31.31.5-1.3-1.31.0-1.01.10.0
Bone: tissue strength0.30.40.60.4-0.60.60.70.60.8-0.6-0.60.6-0.60.60.0
Total heroin consumption1.41.75.1-2.31.7-1.6-1.3-1.7-1.80.91.0-0.10.3-0.30.0
Bone: trabecular number1.52.76.0-0.7-1.11.11.81.21.3-1.7-1.92.4-2.32.50.0
Bone: trabecular spacing0.40.61.60.50.3-0.3-0.8-0.4-0.70.60.9-1.01.1-1.30.0
Bone: trabecular thickness1.72.33.40.5-1.51.41.81.61.8-1.6-1.71.7-1.71.80.0
Bone: trabecular tissue density0.91.69.93.1-1.01.00.31.01.00.10.3-1.51.2-1.30.0
Water consumed over 24 hours0.10.21.2-1.10.3-0.30.2-0.2-0.2-0.0-0.20.7-0.60.60.0
Number of responses in last shaping day0.10.10.3-0.30.3-0.1-0.5-0.5-0.60.10.5-0.20.4-0.40.0