Rarg

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	alternative TSS	XM_039079887.2	0.2	0.03	2.8e-03	0.03	0.02	0.01	0.03	9.6e-03	2.0e-02	8.5e-02	8.7e-03
2	BLA	alternative TSS	XM_039079887.2	0.21	0.02	2.1e-03	0.03	0.03	0.01	0.03	1.8e-02	1.5e-02	9.1e-02	8.3e-03
3	BLA	isoform ratio	XM_008765785.4	0.23	0	1.1e-03	0.01	0.03	0.02	0.02	8.6e-02	7.3e-03	3.6e-02	2.4e-02
4	PL	gene expression	Rarg	0.06	0.06	6.3e-03	0.01	0.01	0.01	0.02	2.4e-02	1.1e-02	3.2e-02	5.4e-03
5	Brain	mRNA stability	Rarg	0.17	0.09	1.2e-07	0.03	0.07	0.04	0.05	4.9e-04	4.5e-07	5.6e-05	1.5e-05
6	Brain	isoform ratio	XM_039079887.2	0.07	0.04	5.7e-05	0.04	0.05	0.04	0.04	2.4e-04	3.1e-05	5.2e-05	6.3e-05
7	BLA	alternative TSS	XM_008765784.4	0.18	0.04	2.3e-03	0	0.04	0.01	0	2.5e-01	2.8e-03	6.3e-02	2.5e-01
8	pVTA	intron excision ratio	chr7_135250819_135250996	0.06	0.04	8.5e-04	0.01	0.03	0.03	0.01	9.8e-02	2.4e-03	2.2e-03	2.2e-02
9	pVTA	intron excision ratio	chr7_135250730_135250996	0.06	0.04	8.4e-04	0	0.03	0.03	0.02	1.1e-01	2.3e-03	2.2e-03	1.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	1.1	1.9	2.8	-1.7	-1.7	-1.5	1.6	1.5	1.2	1.5	0.7	-0.7
Area under the delay curve	0.2	0.3	0.5	-0.7	-0.6	-0.7	0.7	0.4	0.7	0.0	0.2	-0.2
BMI with tail	2.1	7.1	12.6	-3.1	-3.2	-3.2	3.5	3.2	2.2	1.0	1.6	-1.7
BMI without tail	0.8	2.6	4.5	-2.1	-2.0	-1.9	1.7	1.8	1.4	0.5	1.0	-1.0
Body weight	0.6	2.8	5.6	-2.3	-2.4	-1.9	1.9	1.6	1.3	1.4	0.8	-0.7
Weight adjusted by age	0.7	1.1	2.9	0.0	-0.3	0.1	0.4	-0.4	-1.6	1.1	-1.7	1.6
Bone surface	2.2	4.0	5.2	-2.3	-2.1	-2.1	2.2	2.1	2.1	1.1	1.9	-1.9
Bone volume	2.1	3.8	5.1	-2.2	-2.1	-2.1	2.2	2.3	2.0	0.9	1.7	-1.7
Breakpoint value in progressive ratio session	1.3	1.6	2.9	-1.0	-0.7	-1.1	1.1	1.2	1.6	-0.6	1.7	-1.7
Number of licking bursts	0.2	0.3	0.6	0.3	0.5	0.2	-0.5	0.7	-0.1	-0.8	0.5	-0.5
Context. condit. distance diff. score	0.5	0.6	1.5	0.1	0.3	-0.1	0.0	0.7	0.9	-0.8	1.2	-1.2
Locomotion velocity, session 1	5.3	5.7	11.9	2.5	2.4	2.9	-3.4	-2.6	-2.3	0.3	-1.9	1.9
Locomotion distance, session 1	2.8	3.6	5.7	2.0	1.9	2.1	-2.4	-1.6	-2.3	0.0	-1.8	1.8
Locomotion velocity, session 2	3.0	3.5	5.5	0.9	0.8	1.9	-2.4	-1.6	-2.1	2.1	-2.3	2.2
Locomotion distance, session 2	2.9	4.0	5.5	2.3	2.3	2.3	-2.3	-1.8	-2.3	-0.0	-1.8	1.7
Locomotion velocity, session 3	2.9	3.4	7.8	1.5	1.6	2.3	-2.8	-2.1	-1.5	1.0	-1.5	1.5
Locomotion distance, session 3	2.2	2.4	6.2	1.2	1.3	2.1	-2.5	-1.5	-1.2	1.1	-1.1	1.1
Stereotopy head waving bouts, day 3	1.6	1.8	2.4	-1.2	-1.1	-1.6	1.5	1.5	1.3	-0.8	1.4	-1.5
Stereotopy head waving duration, day 3	0.3	0.3	0.6	-0.5	-0.5	-0.5	0.4	0.3	0.8	-0.3	0.7	-0.7
Locomotion velocity, session 7	1.4	1.5	3.3	1.6	1.8	1.2	-1.2	-1.1	-0.1	-1.7	0.6	-0.6
Locomotion distance, session 7	2.5	3.2	6.4	1.8	1.9	2.1	-2.5	-2.4	-1.5	-0.2	-1.1	1.2
Stereotopy head waving bouts, day 7	2.3	2.6	4.1	-1.1	-1.0	-1.8	2.0	1.8	1.4	-1.7	1.6	-1.7
Stereotopy head waving duration, day 7	1.9	2.3	3.2	-1.3	-1.2	-1.7	1.8	1.5	1.6	-1.1	1.6	-1.6
Locomotion velocity, session 8	0.2	0.3	0.5	0.5	0.6	0.5	-0.7	-0.2	0.3	-0.7	0.6	-0.6
Locomotion distance, session 8	1.9	2.7	5.1	2.0	2.1	2.2	-2.3	-1.3	-1.6	0.0	-1.1	1.1
Degree of sensitization distance	0.2	0.2	1.3	0.2	0.3	-0.2	0.4	-0.2	0.1	-1.1	0.2	-0.2
Degree of sensitization stereotypy	1.6	1.7	2.5	-0.9	-0.9	-1.5	1.6	1.4	1.2	-1.3	1.3	-1.4
Conditioned locomotion	0.8	0.9	1.8	1.2	1.3	1.3	-1.3	-0.6	-0.8	0.1	-0.4	0.4
Cocaine response after cond. corrected	0.8	1.0	2.2	1.0	0.9	0.9	-0.8	-0.7	-1.5	-0.1	-1.2	1.2
Cocaine response after cond. not corrected	0.9	1.1	2.0	1.2	1.1	1.0	-0.7	-0.9	-1.4	-0.1	-1.2	1.2
Cocaine response before conditioning	0.3	0.4	0.9	0.7	0.8	0.6	-0.5	-0.9	0.4	-0.6	0.4	-0.3
Saline control response	0.4	0.5	1.5	1.1	1.2	0.7	-0.3	-0.2	0.0	-1.1	0.3	-0.3
Bone: connectivity density	0.1	0.2	1.0	-0.3	-0.2	-0.3	0.6	0.3	0.3	1.0	0.2	-0.2
Bone: cortical apparent density	0.6	0.8	1.9	1.1	1.1	0.4	-0.1	-0.3	-1.4	-1.3	-0.9	0.8
Bone: cortical area	1.1	1.7	3.6	-1.5	-1.5	-1.5	1.9	1.6	1.0	0.8	0.7	-0.7
Bone: cortical porosity	0.5	0.5	1.4	0.6	0.7	0.9	-1.0	-1.2	-0.2	0.6	-0.2	0.3
Bone: cortical porosity	0.5	0.6	1.2	0.8	0.8	1.0	-0.9	-1.1	-0.4	0.7	-0.4	0.5
Bone: cortical thickness	0.1	0.2	0.8	-0.5	-0.6	-0.6	0.9	0.3	-0.0	0.4	-0.2	0.2
Bone: cortical thickness	2.4	2.8	5.2	1.3	1.2	1.4	-0.8	-1.7	-2.1	1.5	-2.3	2.3
Bone: cortical tissue density	0.7	0.9	2.2	1.1	1.1	0.5	-0.2	-0.3	-1.5	-1.2	-1.0	0.9
Condit. Reinf. active minus inactive responses	0.7	0.8	1.6	1.3	1.2	1.1	-1.0	-0.8	-0.7	-0.2	-0.5	0.5
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.7	0.9	0.8	0.8	-0.7	-0.7	-0.7	0.4	-0.7	0.7
Condit. Reinf. active responses	1.6	2.0	3.5	1.9	1.8	1.7	-1.5	-1.3	-1.4	0.1	-1.2	1.1
Condit. Reinf. inactive responses	1.9	2.3	3.6	1.9	1.9	1.8	-1.7	-1.5	-1.5	-0.1	-1.2	1.2
Incentive salience index mean	0.3	0.3	0.9	0.9	0.9	0.6	-0.4	-0.2	-0.6	-0.2	-0.4	0.3
Condit. Reinf. lever presses	0.1	0.1	0.6	0.1	0.1	-0.3	0.4	0.8	-0.1	-0.6	0.2	-0.2
Condit. Reinf. active minus inactive responses	0.5	0.7	1.1	-0.5	-0.5	-1.0	1.1	0.7	0.7	-1.1	0.8	-0.8
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.6	-0.5	-0.5	-0.7	0.8	0.5	0.5	-0.4	0.4	-0.4
Condit. Reinf. active responses	0.8	1.2	3.6	-0.3	-0.3	-0.9	0.9	0.7	1.0	-1.9	1.3	-1.3
Condit. Reinf. inactive responses	0.3	0.4	1.9	0.6	0.6	0.1	-0.2	-0.1	0.1	-1.4	0.5	-0.6
Condit. Reinf. lever presses	0.5	0.7	1.6	1.3	1.3	0.8	-0.7	-1.0	-0.0	-1.1	0.0	-0.0
Condit. Reinf. lever reinforcers received	0.4	0.6	3.2	0.3	0.3	-0.3	0.3	0.2	0.6	-1.8	0.9	-0.9
Conditioned reinforcement - actives	0.6	1.1	6.0	0.8	1.0	0.3	-0.8	-1.0	0.4	-2.4	0.5	-0.4
Conditioned reinforcement - inactives	1.3	1.9	3.6	1.8	1.9	1.3	-0.7	-1.9	-0.9	-1.2	-1.0	1.0
Conditioned locomotion	0.5	0.7	3.3	0.3	0.6	0.1	-0.5	-0.8	0.8	-1.8	0.7	-0.6
Patch foraging indifference point 0 sec	0.7	1.4	2.5	1.6	1.6	1.4	-1.6	-0.7	-1.1	-1.0	-0.3	0.3
Patch foraging indifference point AUC	0.5	0.7	1.5	1.0	1.0	0.5	-0.5	-0.0	-1.0	-1.2	-0.8	0.7
Delay disc. indifference point, 0s delay	0.0	0.0	0.2	-0.2	-0.2	-0.1	-0.0	-0.3	-0.2	0.5	-0.1	0.2
Delay disc. indifference point, 16s delay	0.1	0.1	0.6	-0.2	-0.2	-0.5	0.8	0.4	0.4	0.0	0.0	-0.0
Delay disc. indifference point, 2s delay	3.1	3.5	5.6	-1.7	-1.6	-2.4	2.1	1.9	1.7	-1.7	1.8	-1.9
Delay disc. indifference point, 24s delay	0.1	0.2	0.3	-0.5	-0.4	-0.5	0.5	0.5	0.5	-0.1	-0.1	0.1
Delay disc. indifference point, 4s delay	0.5	0.5	0.9	-0.7	-0.5	-0.9	0.9	0.6	1.0	-0.3	0.8	-0.8
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.4	-0.2	-0.1	-0.1	-0.1	0.4	0.4	-0.1	0.1
Indifference point function ln k	1.2	2.0	3.2	-1.8	-1.7	-1.2	0.9	0.9	1.5	1.8	1.4	-1.3
Indifference point function log k	1.2	2.0	3.2	-1.8	-1.7	-1.2	0.9	0.9	1.5	1.8	1.4	-1.3
Patch foraging total patch changes 0 sec	1.0	1.8	3.8	1.7	1.7	1.7	-1.9	-1.0	-1.3	-0.6	-0.6	0.7
Patch foraging total patch changes 12 sec	2.2	2.8	5.7	2.4	2.4	1.7	-1.6	-1.0	-1.5	-2.1	-0.7	0.7
Patch foraging total patch changes 18 sec	1.7	2.6	4.9	2.2	2.2	1.7	-1.8	-0.7	-1.7	-1.8	-0.8	0.8
Patch foraging total patch changes 24 sec	0.4	0.7	3.1	1.0	1.0	0.7	-0.9	0.2	-0.6	-1.8	-0.0	-0.0
Patch foraging total patch changes 6 sec	0.8	1.3	2.9	1.2	1.2	1.0	-1.7	-0.7	-1.1	-1.7	-0.3	0.3
Patch foraging time to switch 0 sec	0.0	0.1	0.5	0.1	0.1	-0.1	0.1	-0.6	-0.2	-0.7	0.1	-0.0
Patch foraging water rate 0 sec	0.1	0.1	0.7	-0.3	-0.3	-0.2	0.1	0.8	0.4	0.3	0.1	-0.2
Patch foraging water rate 12 sec	0.1	0.2	0.9	-0.1	-0.1	0.5	-0.6	-0.0	0.2	0.9	-0.1	0.1
Patch foraging water rate 18 sec	0.1	0.1	0.4	0.3	0.3	0.2	-0.3	-0.0	0.2	-0.7	0.3	-0.3
Patch foraging water rate 24 sec	0.5	0.7	1.2	-0.6	-0.6	-0.7	0.5	1.0	1.0	-0.6	1.1	-1.1
Patch foraging water rate 6 sec	0.4	0.6	1.6	-0.8	-0.8	-0.4	0.6	1.3	1.0	1.0	0.4	-0.4
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.7	0.5	0.6	0.4	-0.0	-0.9	-0.3	-0.1	-0.3	0.4
Distance traveled before self-admin	0.0	0.1	0.1	-0.1	-0.1	-0.2	0.3	-0.1	0.4	-0.2	0.3	-0.2
Distance traveled after self-admin	0.5	0.7	1.3	0.9	1.0	0.7	-0.4	-1.1	1.0	-1.1	0.4	-0.3
Extensor digitorum longus weight	6.2	24.2	39.2	-5.9	-5.9	-6.3	5.7	5.1	4.3	-0.3	4.0	-4.0
Bone: elastic displacement	2.6	3.0	7.8	1.7	2.0	2.2	-2.6	-2.8	-0.5	-0.4	-0.5	0.6
Bone: elastic work	1.3	1.7	5.0	0.4	0.5	1.3	-1.7	-2.2	-0.7	1.2	-1.2	1.3
Bone: endosteal estimation	2.3	5.0	7.6	-2.8	-2.7	-2.3	2.2	2.6	2.3	1.3	1.8	-1.8
Bone: endosteal perimeter	2.4	5.0	7.9	-2.8	-2.8	-2.4	2.6	2.8	2.0	1.4	1.4	-1.4
Epididymis fat weight	0.9	3.1	6.1	1.1	1.0	2.0	-1.7	-2.2	-0.9	2.5	-1.8	1.9
Delta time in closed arm before/after self-admin	0.7	0.6	1.4	-0.4	-0.4	-0.6	0.6	0.7	1.1	-0.6	1.2	-1.2
Delta time in open arm before/after self-admin	3.5	3.4	4.9	1.3	1.3	2.0	-1.7	-2.2	-1.9	1.6	-2.2	2.2
Diff in mean of infusions in LGA sessions	0.3	0.4	1.1	-0.5	-0.6	-0.7	1.1	0.6	-0.2	0.9	-0.1	0.1
Delay discount exponential model param	0.5	0.5	0.9	0.9	0.8	1.0	-0.9	-0.6	-0.9	0.0	-0.4	0.4
Extinction: sum of active levers before priming	3.6	4.0	7.0	-2.6	-2.7	-2.2	1.7	2.4	1.5	1.4	1.5	-1.5
Active lever presses in extinction session 6	0.3	0.3	0.6	-0.5	-0.2	-0.4	0.3	0.7	0.8	0.0	0.7	-0.7
Bone: final force	2.4	3.9	7.2	-2.7	-2.7	-2.1	2.0	2.1	1.5	2.0	0.9	-0.9
Bone: final moment	2.9	4.7	8.6	-2.9	-2.9	-2.3	2.1	2.2	1.9	2.0	1.2	-1.2
Food consumed during 24 hour testing period	0.1	0.1	0.4	0.1	0.2	0.4	-0.3	0.1	0.3	0.6	0.2	-0.2
Glucose	0.4	0.6	1.5	0.7	0.9	0.9	-1.1	-1.2	-0.7	-0.0	-0.4	0.4
Heart weight	0.2	0.3	1.4	0.0	0.0	-0.0	0.7	0.5	0.1	1.2	-0.3	0.3
Delay discount hyperbolic model param	0.6	0.6	1.2	1.0	0.9	1.1	-1.0	-0.7	-0.9	0.1	-0.4	0.5
Intermittent access intake day 1-15 change	0.0	0.1	0.3	0.1	0.3	0.3	-0.5	-0.1	0.4	-0.2	0.3	-0.3
Intermittent access intake escalation	0.0	0.0	0.1	-0.0	0.0	0.1	-0.2	0.1	0.2	0.2	0.2	-0.2
Intermittent access intake escalation 2	0.1	0.1	0.2	0.3	0.4	0.3	-0.3	-0.2	0.0	0.2	0.2	-0.2
Intermitt. access day 1 inactive lever presses	0.2	0.6	2.0	0.1	-0.1	-0.8	1.2	0.3	0.7	-1.4	0.6	-0.7
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.3	0.3	0.3	0.1	0.3	-0.6	0.0	0.1	-0.2	0.2
Intermitt. access escalation Index	1.2	1.7	3.9	-0.9	-0.9	-1.4	0.9	1.0	1.2	-2.0	1.5	-1.5
Intermittent access day 1 total infusions	0.8	1.2	5.3	1.4	1.5	0.7	-0.5	-0.8	-0.2	-2.3	0.1	-0.1
Intermittent access day 15 total infusions	0.7	1.1	4.2	1.2	1.4	0.7	-0.9	-0.9	-0.2	-2.1	0.3	-0.2
Intermittent access terminal intake (last 3 days)	1.3	1.8	9.0	1.3	1.6	0.5	-0.7	-0.8	0.3	-3.0	0.8	-0.7
Intermittent access total infusions	1.4	1.6	9.1	1.2	1.5	0.3	-0.4	-0.6	0.3	-3.0	0.9	-0.8
Intermittent access day 1 locomotion	0.8	1.0	5.8	0.9	1.0	0.2	-0.4	-0.3	0.5	-2.4	0.7	-0.6
Intermittent access day 15 total locomotion	0.1	0.2	0.5	0.2	0.3	0.5	-0.5	-0.7	0.6	0.1	0.2	-0.1
Intermittent access total locomotion	0.6	0.7	2.9	0.8	0.9	0.3	-0.4	-0.5	0.7	-1.7	0.8	-0.7
Intermittent access standard deviation	0.6	1.3	2.5	1.4	1.6	1.4	-1.1	-1.4	-1.0	-0.1	-0.8	0.9
Left kidney weight	0.1	0.7	2.9	-0.4	-0.5	-0.3	0.7	0.3	-0.6	1.7	-1.0	1.0
Right kidney weight	0.5	2.2	6.7	-1.8	-2.1	-1.3	1.5	0.9	0.0	2.6	-0.7	0.8
Cocaine induced anxiety	0.7	1.0	2.5	-1.3	-1.1	-0.9	0.1	0.3	1.6	-0.1	1.2	-1.2
Post-drug Anxiety	0.9	0.9	2.8	-0.8	-0.9	-0.7	0.3	0.7	1.7	0.2	1.2	-1.2
Baseline Anxiety	0.5	0.6	1.3	0.7	0.5	0.6	0.4	0.2	-1.0	1.1	-0.9	0.9
Tail length	0.4	1.4	3.5	1.2	1.4	1.5	-1.9	-1.6	-0.7	-0.4	-0.6	0.7
Length with tail	0.1	0.4	1.1	0.2	0.2	0.7	-0.8	-1.1	-0.4	0.6	-0.5	0.6
Length without tail	0.1	0.5	0.8	-0.9	-0.9	-0.6	0.7	0.1	0.7	0.9	0.5	-0.4
Times rat made contact with spout	0.2	0.2	0.8	-0.5	-0.5	0.0	-0.2	0.3	0.6	0.9	0.4	-0.4
Lifetime Intake	1.3	1.6	9.3	1.1	1.3	0.3	-0.5	-0.5	0.5	-3.0	0.9	-0.9
Liver weight, left	3.4	5.6	9.8	-3.1	-3.1	-2.5	2.1	1.9	2.8	1.4	1.9	-1.9
Liver weight, right	0.4	0.7	2.9	-1.0	-1.1	-0.6	0.8	0.2	0.2	1.7	-0.2	0.2
Locomotor activity	0.0	0.1	0.3	0.1	0.2	0.1	-0.5	-0.5	0.1	-0.2	0.3	-0.2
Locomotor testing distance	0.2	0.4	1.4	0.5	0.6	0.5	-1.2	-0.8	0.1	-0.7	0.5	-0.4
Locomotor testing rearing	0.1	0.2	0.7	-0.2	-0.2	0.2	-0.8	-0.4	-0.1	0.6	-0.1	0.1
Locomotion in novel chamber	3.7	4.7	7.3	-2.7	-2.5	-2.7	2.3	2.0	2.3	0.2	2.0	-1.9
Locomotion in novel chamber post-restriction	0.6	1.0	3.9	-0.4	-0.2	-0.8	0.7	0.5	0.9	-2.0	1.1	-1.1
Fecal boli incidents, locomotor time 1	2.2	3.3	5.7	1.6	1.8	2.2	-2.4	-2.0	-1.5	0.5	-1.7	1.7
Change in fecal boli incidents, locomotor task	0.8	0.8	1.3	-0.7	-0.8	-1.1	1.1	1.0	0.8	-0.1	1.0	-1.0
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.2	0.8	1.1	1.0	-0.7	-0.9	-0.3	0.0	-0.3	0.3
Bouts of movement, locomotor time 1	1.0	1.1	2.0	1.4	1.4	1.1	-0.6	-0.9	-1.3	-0.1	-1.1	1.1
Total resting periods, locomotor time 1	1.8	2.0	2.8	1.7	1.6	1.5	-1.2	-1.3	-1.7	0.3	-1.5	1.5
Rest time, locomotor task time 1	0.4	0.5	1.5	0.5	0.5	0.8	-1.2	-0.8	-0.6	-0.0	-0.6	0.7
Distance moved, locomotor task time 1	0.6	0.9	1.6	-0.2	-0.2	-0.8	1.0	0.9	0.9	-1.3	1.2	-1.3
Vertical activity count, locomotor time 1	0.4	0.9	3.0	-0.6	-0.7	-1.3	1.7	1.0	0.6	-1.0	0.5	-0.5
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.6	0.5	0.8	0.4	-0.2	-0.6	0.0	-0.4	0.2	-0.1
Bouts of movement, locomotor time 2	1.1	1.8	2.9	-1.2	-1.2	-1.7	1.7	1.6	1.1	-0.7	1.3	-1.3
Total resting periods, locomotor time 2	1.1	1.9	3.2	-1.1	-1.1	-1.7	1.8	1.7	1.1	-0.9	1.3	-1.3
Rest time, locomotor task time 2	0.4	0.5	1.3	0.8	0.8	0.8	-1.1	-0.4	-0.7	-0.5	-0.5	0.5
Distance moved, locomotor task time 2	0.1	0.1	0.2	-0.1	-0.2	-0.2	0.5	-0.1	-0.0	0.4	0.1	-0.1
Vertical activity count, locomotor time 2	0.3	0.4	1.0	-0.9	-1.0	-0.9	1.0	0.3	0.3	0.2	0.1	-0.1
Light reinforcement 1	0.5	1.3	2.8	1.6	1.5	1.1	-0.7	-0.2	-1.7	-0.9	-0.9	0.9
Light reinforcement 2	1.1	1.8	3.7	1.4	1.2	1.2	-0.9	-1.2	-1.9	-0.1	-1.6	1.6
Bone: marrow area	2.2	4.8	7.2	-2.7	-2.6	-2.2	2.1	2.6	2.3	1.2	1.8	-1.8
Bone: maximum diameter	0.9	1.7	3.0	-1.3	-1.2	-1.4	1.6	1.7	1.3	-0.1	1.2	-1.2
Bone: maximum force	2.2	3.8	6.6	-2.6	-2.5	-2.2	2.1	2.2	1.6	1.2	1.2	-1.2
Bone: maximum moment	2.6	4.6	8.0	-2.8	-2.8	-2.4	2.1	2.3	2.0	1.3	1.5	-1.5
Mean time between licks in bursts	0.3	0.8	3.4	0.5	0.5	0.9	-1.8	-1.4	-0.1	-0.6	0.2	-0.2
Mean num. licks in bursts	0.3	0.4	2.1	-0.5	-0.6	0.1	0.1	-0.8	0.3	1.4	-0.4	0.4
Cd content in liver	0.6	0.7	1.4	0.8	1.0	0.6	-1.0	-1.2	0.2	-1.1	0.4	-0.4
Co content in liver	0.4	0.5	0.7	-0.8	-0.7	-0.7	0.3	0.7	0.7	-0.1	0.8	-0.8
Cu content in liver	5.1	6.0	10.0	-2.3	-2.1	-2.4	2.3	2.5	3.2	-0.5	2.9	-2.8
Fe content in liver	0.2	0.2	0.6	-0.4	-0.1	-0.2	-0.3	0.1	0.6	-0.5	0.8	-0.8
K content in liver	0.9	0.9	2.2	-1.4	-1.5	-0.9	0.5	1.2	0.7	0.8	0.1	-0.2
Mg content in liver	0.5	0.5	1.0	-1.0	-0.9	-0.5	-0.2	0.8	1.0	0.1	0.7	-0.7
Mn content in liver	0.0	0.1	0.2	-0.3	-0.4	-0.0	-0.4	-0.1	-0.2	0.1	-0.2	0.1
Na content in liver	1.3	1.3	1.9	-1.4	-1.3	-1.1	0.8	1.0	1.4	0.2	1.3	-1.3
Rb content in liver	1.5	1.7	4.3	-0.8	-0.3	-0.6	0.0	0.8	2.0	-1.3	2.1	-2.0
Se content in liver	0.4	0.5	1.0	0.6	0.7	0.9	-1.0	-0.9	-0.5	0.1	-0.7	0.8
Sr content in liver	0.3	0.3	2.1	-0.1	-0.3	0.2	-0.3	-0.1	-0.4	1.5	-0.2	0.2
Zn content in liver	0.6	0.7	1.3	1.1	1.1	1.1	-0.7	-0.4	-0.7	0.2	-0.8	0.8
Bone: minimum diameter	1.9	3.5	5.9	-2.1	-2.2	-2.1	2.4	2.1	1.8	0.8	1.3	-1.3
Time in familiar zone, hab. session 1	0.5	0.5	1.4	0.1	0.0	0.5	-0.5	-0.9	-0.5	1.2	-0.8	0.9
Time in novel zone, hab. session 1	1.1	1.1	3.0	-0.2	-0.2	-0.9	1.0	1.3	0.8	-1.7	1.1	-1.1
Total zone transitions, hab. session 1	0.5	0.7	1.7	1.3	1.2	0.5	-0.1	-0.0	-1.1	-1.2	-0.5	0.4
Total locomotion distance, hab. session 1	1.8	2.6	4.2	2.1	1.9	1.7	-1.2	-0.9	-2.1	0.3	-1.8	1.7
Locomotion velocity, hab. session 1	1.4	2.0	3.4	1.6	1.4	1.5	-1.2	-0.8	-1.8	0.7	-1.6	1.6
Time in familiar zone, hab. session 2	0.9	1.0	2.1	-1.5	-1.4	-0.9	0.4	0.3	1.2	1.0	0.8	-0.8
Time in novel zone, hab. session 2	0.3	0.3	1.3	0.6	0.6	0.2	0.0	0.4	-0.3	-1.1	0.1	-0.1
Total zone transitions, hab. session 2	1.0	1.3	2.3	1.2	1.2	1.1	-0.9	-0.7	-1.5	0.2	-1.4	1.4
Total locomotion distance, hab. session 2	2.2	2.9	5.7	1.5	1.3	1.5	-1.0	-0.5	-2.3	1.5	-2.4	2.3
Locomotion velocity, hab. session 2	2.4	3.3	6.5	1.4	1.2	1.6	-1.1	-0.6	-2.4	1.9	-2.5	2.4
Novel to familiar place preference ratio	0.2	0.2	0.8	-0.2	-0.4	-0.5	0.9	0.9	-0.1	0.2	-0.1	0.1
Novelty place preference	0.1	0.2	0.6	-0.3	-0.4	-0.4	0.6	0.8	-0.0	0.1	0.0	-0.1
Time in novel zone, NPP test	0.2	0.2	0.9	-0.3	-0.4	-0.6	0.7	0.9	0.2	0.0	0.3	-0.3
Total zone transitions, NPP test	3.4	4.8	7.3	2.6	2.5	2.3	-2.0	-1.7	-2.7	-0.4	-2.4	2.3
Total locomotion distance, NPP test	5.9	8.0	13.7	2.7	2.4	2.8	-2.3	-1.9	-3.6	1.5	-3.7	3.6
Locomotion velocity, NPP test	6.2	8.7	15.5	2.7	2.4	2.9	-2.4	-2.0	-3.8	1.8	-3.9	3.9
Intraocular pressure	1.5	2.2	7.5	1.3	1.6	0.9	-1.4	-1.3	0.8	-2.7	1.3	-1.2
Delta distance traveled before/after self-admin	1.3	1.3	2.7	1.5	1.5	1.6	-1.2	-1.3	-0.2	0.4	-0.9	0.9
Delta ambulatory time before/after self-admin	0.8	1.0	2.2	1.4	1.4	1.5	-0.9	-1.1	0.1	0.2	-0.6	0.6
Parametrial fat weight	0.6	1.3	2.7	1.5	1.6	1.4	-1.6	-1.0	0.0	-1.2	0.2	-0.2
Pavlov. Cond. lever latency	1.2	1.5	3.7	0.6	0.4	1.1	-1.2	-1.9	-0.9	1.3	-1.4	1.5
Pavlov. Cond. magazine entry latency	1.7	2.2	3.3	-1.4	-1.3	-1.8	1.5	1.4	1.4	-1.5	1.5	-1.5
Pavlov. Cond. change in total contacts	2.8	3.0	4.8	-1.4	-1.4	-2.0	2.0	2.2	1.5	-1.2	1.7	-1.8
Pavlov. Cond. index score	3.1	3.9	6.3	-1.8	-1.6	-2.4	2.2	2.5	1.7	-1.5	2.0	-2.0
Pavlov. Cond. latency score	3.2	4.1	6.9	-1.7	-1.4	-2.3	2.1	2.6	1.8	-1.6	2.2	-2.2
Pavlov. Cond. lever contacts	1.4	1.6	3.8	-0.9	-0.8	-1.3	1.2	2.0	1.0	-1.2	1.4	-1.4
Pavlov. Cond. magazine entry number	1.2	1.5	2.2	1.0	0.9	1.5	-1.3	-1.2	-1.1	1.4	-1.3	1.3
Pavlov. Cond. intertrial magazine entries	2.6	3.1	5.3	2.3	2.1	2.2	-2.0	-2.1	-1.4	-0.4	-1.2	1.2
Pavlov. Cond. lever-magazine prob. diff.	3.1	3.8	5.9	-1.8	-1.6	-2.3	2.1	2.4	1.7	-1.5	2.0	-2.0
Pavlov. Cond. response bias	0.9	1.1	1.5	-0.9	-0.7	-1.2	0.9	1.0	0.9	-1.2	1.1	-1.1
Pavlov. Cond. lever latency	1.5	2.0	3.9	-1.9	-2.0	-1.7	1.4	1.7	0.9	0.7	0.9	-0.9
Pavlov. Cond. magazine entry latency	3.3	4.0	6.7	1.8	1.7	2.2	-2.1	-2.6	-2.0	0.8	-2.2	2.2
Pavlov. Cond. change in total contacts	0.2	0.3	1.7	0.2	0.1	-0.4	0.7	0.4	0.2	-1.3	0.3	-0.3
Pavlov. Cond. index score	2.3	3.1	4.4	2.0	1.9	2.0	-1.7	-2.1	-1.6	-0.1	-1.7	1.7
Pavlov. Cond. latency score	2.3	3.0	4.0	1.9	1.9	2.0	-1.7	-2.0	-1.7	-0.0	-1.8	1.8
Pavlov. Cond. lever contacts	2.1	2.9	5.1	2.2	2.3	2.1	-1.7	-2.0	-1.2	-0.5	-1.2	1.2
Pavlov. Cond. magazine entry number	1.2	1.5	2.5	-1.3	-1.2	-1.4	1.1	1.6	1.2	-0.2	1.3	-1.3
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.9	0.4	0.6	0.7	-1.0	-0.5	0.2	0.2	0.3	-0.3
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.3	3.6	1.7	1.6	1.7	-1.4	-1.9	-1.4	-0.1	-1.5	1.5
Pavlov. Cond. response bias	1.5	2.1	3.8	1.8	1.8	1.8	-1.5	-1.9	-0.9	-0.3	-1.1	1.1
Time in closed arm before self-admin	0.2	0.3	0.6	-0.4	-0.6	-0.7	0.8	0.7	-0.4	0.1	-0.2	0.2
Time in closed arm after self-admin	1.9	2.0	2.9	-0.8	-0.9	-1.6	1.6	1.6	1.1	-1.7	1.5	-1.6
Time in open arm before self-admin	1.6	1.7	3.5	-0.9	-0.6	-1.3	0.9	0.9	1.7	-1.9	1.5	-1.5
Time in open arm after self-admin	0.9	0.9	1.7	0.5	0.6	0.9	-0.6	-1.1	-0.8	1.1	-1.3	1.3
Bone: periosteal estimation	2.8	6.0	8.6	-2.9	-2.9	-2.6	2.8	2.9	2.4	1.3	1.8	-1.8
Bone: periosteal perimeter	2.9	4.9	7.5	-2.6	-2.6	-2.5	2.7	2.7	2.0	0.9	1.5	-1.5
Bone: post-yield work	1.3	1.9	2.8	-1.7	-1.6	-1.5	1.3	1.7	1.3	0.5	1.2	-1.2
Progressive ratio test 1 active lever presses	2.1	2.6	8.2	2.0	2.2	1.4	-1.7	-1.3	-0.5	-2.9	-0.0	0.1
Progressive ratio test 1 breakpoint	2.2	2.7	8.1	2.0	2.2	1.5	-1.8	-1.3	-0.5	-2.8	0.0	0.1
Progressive ratio test 1 inactive lever presses	0.5	0.8	4.0	1.2	1.2	0.0	0.5	-0.3	-0.2	-2.0	0.1	-0.1
Progressive ratio test 2 active lever presses	1.2	1.4	7.3	0.4	0.8	-0.3	0.3	0.1	1.1	-2.7	1.2	-1.2
Progressive ratio test 2 breakpoint	1.2	1.4	7.3	0.3	0.7	-0.4	0.4	0.3	1.2	-2.7	1.3	-1.2
Progressive ratio test 2 inactive lever presses	0.3	0.6	2.6	0.5	0.7	-0.1	0.3	-0.4	0.8	-1.6	0.7	-0.6
Incentive Sensitization - Responses	0.9	1.2	2.0	-1.0	-0.6	-1.2	1.3	1.1	1.4	-0.9	1.1	-1.1
Incentive Sensitization - Breakpoint	1.2	1.5	2.2	-1.1	-0.8	-1.3	1.5	1.3	1.5	-1.0	1.2	-1.3
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.4	0.2	0.4	-0.1	0.3	-0.1	-0.2	-0.6	0.1	-0.1
Progressive ratio	0.1	0.2	0.6	0.2	0.2	-0.1	-0.1	-0.1	0.4	-0.7	0.6	-0.6
Food seeking constrained by brief footshock	1.0	1.2	5.9	1.4	1.6	0.4	0.2	0.1	0.1	-2.4	0.2	-0.2
Seeking ratio, punishment vs. effort	0.2	0.2	0.8	0.7	0.7	0.3	0.1	-0.2	-0.2	-0.9	-0.3	0.3
Retroperitoneal fat weight	1.6	6.7	12.8	3.0	3.1	3.4	-3.6	-3.3	-1.3	-0.3	-1.5	1.6
Reaction time number correct	0.2	0.4	0.9	-0.8	-0.7	0.1	-0.8	-0.5	0.7	0.9	0.2	-0.2
Reaction time mean minus median	0.1	0.3	0.5	0.6	0.4	0.3	0.0	-0.5	-0.7	-0.4	-0.7	0.7
Reaction time mean minus median AUC	0.1	0.2	1.0	0.4	0.3	0.0	0.1	-0.5	-0.3	-1.0	-0.3	0.3
Reaction time num false alarms	2.5	3.6	6.6	2.6	2.5	2.1	-1.7	-1.4	-2.1	-0.5	-1.7	1.7
Reaction time num false alarms AUC	2.4	3.8	7.0	2.7	2.6	2.0	-1.5	-1.5	-2.2	-0.8	-1.9	1.8
Reaction time trials correct on left	0.2	0.4	0.9	-0.8	-0.7	0.1	-0.8	-0.5	0.7	0.9	0.2	-0.2
Reaction time trials on left	0.2	0.4	1.0	-0.7	-0.6	0.2	-0.8	-0.6	0.6	1.0	0.1	0.0
Reaction time mean	0.1	0.1	0.7	-0.0	-0.2	-0.3	0.8	0.6	0.0	0.2	-0.0	0.0
Reaction time mean AUC	0.2	0.2	0.9	-0.4	-0.5	-0.5	0.9	0.7	0.2	0.4	0.1	-0.1
Median of all reaction times	0.2	0.3	0.9	-0.3	-0.4	-0.5	1.0	1.0	0.3	0.6	0.1	-0.1
Reaction time omissions	2.4	3.6	8.1	1.7	1.4	1.5	-0.3	-1.3	-2.3	1.3	-2.9	2.8
Reaction time false alarm rate	1.8	2.5	5.8	2.4	2.3	1.3	-0.6	-0.7	-1.9	-1.3	-1.4	1.3
Reaction time premature initiation rate	0.6	0.8	1.8	1.3	1.3	1.1	-0.7	-1.0	-0.0	-0.8	0.1	-0.0
Reaction time premature initiations	0.3	0.5	1.5	0.7	0.8	1.0	-1.0	-1.2	0.3	0.0	0.1	-0.0
Std. dev. reaction times	0.1	0.2	0.5	0.4	0.2	0.0	0.4	-0.1	-0.7	-0.2	-0.7	0.7
Reaction time trials completed	0.2	0.4	1.0	-0.7	-0.6	0.2	-0.8	-0.6	0.6	1.0	0.1	0.0
Reaction time trials AUC	0.2	0.4	0.9	-0.8	-0.7	0.0	-0.7	-0.4	0.7	0.9	0.2	-0.2
Run reversals in cocaine runway, females	0.2	0.2	1.2	0.1	0.0	-0.0	0.5	-0.3	-0.2	1.1	-0.3	0.3
Run reversals in cocaine runway, males	0.4	0.4	0.9	-0.7	-0.9	-0.6	0.5	0.2	-0.6	0.5	-0.6	0.5
Latency to leave start box in cocaine runway	0.3	0.3	0.6	-0.5	-0.5	-0.5	0.3	0.5	0.5	-0.4	0.8	-0.8
Latency to leave start box in cocaine runway, F	0.0	0.0	0.2	-0.0	-0.1	-0.0	-0.1	0.3	-0.2	-0.5	0.1	-0.1
Latency to leave start box in cocaine runway, M	1.0	0.9	1.5	-0.9	-0.9	-0.9	0.9	0.7	1.2	-0.1	1.2	-1.2
Std. dev. time between licks in bursts	0.6	0.9	3.4	0.6	0.6	1.1	-1.9	-1.0	-0.7	0.4	-0.6	0.6
Total sessions with >9 infusions	0.8	1.0	6.3	0.9	1.1	0.2	0.0	-0.2	0.2	-2.5	0.3	-0.4
Short access day 1 total inactive lever presses	0.3	0.5	2.2	0.6	0.7	0.1	-0.1	-0.7	0.4	-1.5	0.4	-0.3
Short access day 10 total inactive lever presses	0.1	0.3	1.1	0.2	0.1	-0.5	1.1	0.1	0.6	-0.5	0.5	-0.5
Short access day 1 total infusions	0.3	0.4	2.5	0.6	0.6	0.1	0.2	-0.4	0.6	-1.6	0.3	-0.2
Short access day 10 total infusions	1.1	1.4	7.5	1.3	1.5	0.5	-0.4	-0.4	-0.0	-2.7	0.6	-0.6
Short access total infusions	0.9	1.1	6.4	0.9	1.0	0.2	-0.4	-0.4	0.6	-2.5	0.8	-0.8
Short access day 1 locomotion	0.1	0.1	0.5	0.1	-0.0	-0.3	0.4	0.2	0.3	-0.7	0.0	-0.0
Short access day 10 total locomotion	0.1	0.1	0.4	0.3	0.4	-0.0	0.5	0.2	0.0	-0.6	0.2	-0.2
Short access total locomotion	0.3	0.4	2.5	0.6	0.7	0.1	0.0	0.0	-0.0	-1.6	0.1	-0.1
One hour access (0.3 mA shock)	2.0	2.3	3.3	-1.4	-1.2	-1.7	1.6	1.4	1.8	-1.4	1.5	-1.5
Compulsive drug intake	1.3	1.6	2.9	-0.8	-0.6	-1.3	1.7	1.7	1.3	-1.1	1.2	-1.2
One hour access (shock baseline)	0.5	0.8	1.4	-0.9	-0.8	-1.0	0.5	0.3	1.2	-1.1	1.0	-1.0
Social response proportion	1.8	2.0	3.3	1.4	1.4	1.4	-1.0	-1.8	-1.2	0.4	-1.7	1.8
Social responses	1.8	2.3	5.0	1.1	0.9	1.2	-1.0	-1.2	-2.0	1.0	-2.2	2.2
Social time	1.7	2.3	4.9	0.6	0.4	1.0	-0.7	-1.6	-1.6	2.0	-2.2	2.2
Soleus weight	0.3	0.9	2.0	-1.4	-1.4	-1.0	0.6	0.1	1.1	0.9	0.6	-0.6
Bone: stiffness	4.2	6.9	12.9	-3.1	-3.2	-3.1	3.2	3.6	1.9	1.3	1.4	-1.5
Tibialis anterior weight	5.6	19.1	29.7	-4.6	-4.6	-5.5	5.2	5.2	3.6	-1.6	3.9	-4.0
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.1	-0.1	-0.4	0.5	0.2	-0.0	-0.4	-0.0	-0.0
Time to tail flick, vehicle, after self-admin	0.8	1.1	3.7	-1.1	-1.4	-0.9	0.9	0.9	0.1	1.9	-0.4	0.3
Time to tail flick, test, before self-admin	0.8	0.8	1.9	0.9	0.7	0.5	-0.2	-0.8	-1.4	0.0	-1.2	1.2
Time to tail flick, test, after self-admin	1.1	1.1	2.1	-1.2	-1.4	-1.2	1.4	0.8	0.4	1.4	0.4	-0.4
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	2.6	-0.8	-1.0	-0.4	0.3	0.8	0.3	1.6	0.1	-0.1
Delta time to tail flick, test, before/after SA	0.9	0.9	1.3	-0.9	-1.1	-0.9	1.1	1.0	0.9	1.1	0.7	-0.7
Tibia length	0.4	1.1	1.8	-0.9	-0.9	-0.9	1.0	1.1	1.3	0.4	1.3	-1.2
Ambulatory time before self-admin	0.0	0.1	0.2	0.1	0.2	0.0	-0.0	-0.4	0.2	-0.4	0.4	-0.3
Ambulatory time after self-admin	0.5	0.6	1.4	0.7	0.8	0.5	-0.3	-1.0	1.2	-1.0	0.7	-0.5
Bone: tissue strength	1.9	2.0	2.4	-1.6	-1.4	-1.6	1.2	1.4	1.5	-0.7	1.5	-1.5
Total heroin consumption	1.5	1.7	2.9	-1.4	-1.1	-1.2	1.1	1.4	1.7	0.2	1.5	-1.5
Bone: trabecular number	0.3	0.5	2.5	-0.6	-0.7	-0.4	0.6	0.6	0.2	1.6	-0.2	0.2
Bone: trabecular spacing	1.1	1.4	6.1	0.5	0.8	-0.1	0.1	0.4	0.9	-2.5	1.5	-1.5
Bone: trabecular thickness	0.2	0.2	0.5	0.0	-0.1	-0.1	0.3	0.2	-0.5	0.7	-0.7	0.7
Bone: trabecular tissue density	0.3	0.5	1.6	0.4	0.4	-0.4	0.8	1.0	-0.7	-1.3	-0.4	0.3
Water consumed over 24 hours	0.2	0.3	0.6	-0.2	-0.2	0.2	-0.6	0.1	0.6	0.3	0.8	-0.8
Number of responses in last shaping day	2.9	3.2	5.1	1.5	1.2	1.6	-1.1	-2.1	-2.2	1.4	-2.2	2.3