Hub : Genes

C5h1orf87

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression C5h1orf87 0.11 0.08 5.4e-10 0.08 0.08 0.08 0.08 8.4e-08 2.9e-08 5.5e-08 1.2e-07
2 NAcc gene expression C5h1orf87 0.03 0.03 2.1e-03 0.02 0.02 0.02 0.02 1.7e-03 1.4e-03 4.6e-03 1.9e-03
3 Adipose gene expression C5h1orf87 0.26 0.13 0.0e+00 0.16 0.17 0.16 0.16 7.8e-17 4.7e-18 3.7e-17 6.2e-17

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density1.32.22.41.51.51.4
Area under the delay curve1.81.92.21.51.51.1
BMI with tail0.92.93.1-1.8-1.8-1.6
BMI without tail0.20.40.5-0.7-0.7-0.4
Body weight0.00.00.00.20.20.0
Weight adjusted by age0.80.80.9-1.0-1.0-0.8
Bone surface0.71.31.8-1.0-1.0-1.3
Bone volume0.00.10.1-0.1-0.1-0.3
Breakpoint value in progressive ratio session0.00.00.1-0.2-0.2-0.0
Number of licking bursts0.30.30.5-0.5-0.5-0.7
Context. condit. distance diff. score1.21.41.61.21.11.3
Locomotion velocity, session 10.50.50.70.80.90.5
Locomotion distance, session 11.11.41.61.31.31.1
Locomotion velocity, session 20.00.00.00.10.10.0
Locomotion distance, session 20.00.00.00.20.20.1
Locomotion velocity, session 30.10.10.10.30.40.3
Locomotion distance, session 30.10.10.2-0.4-0.4-0.2
Stereotopy head waving bouts, day 30.00.00.00.0-0.0-0.1
Stereotopy head waving duration, day 30.20.20.30.50.50.1
Locomotion velocity, session 70.40.40.50.70.70.6
Locomotion distance, session 70.20.30.30.50.50.5
Stereotopy head waving bouts, day 72.52.83.2-1.6-1.6-1.8
Stereotopy head waving duration, day 70.91.11.6-1.0-0.9-1.2
Locomotion velocity, session 80.70.80.90.90.90.9
Locomotion distance, session 81.11.71.71.31.31.3
Degree of sensitization distance0.10.10.2-0.2-0.2-0.4
Degree of sensitization stereotypy1.11.21.5-1.0-1.0-1.2
Conditioned locomotion1.01.21.4-1.2-1.2-1.0
Cocaine response after cond. corrected1.31.51.6-1.2-1.3-1.1
Cocaine response after cond. not corrected0.80.80.9-0.9-1.0-0.8
Cocaine response before conditioning0.10.10.20.40.40.3
Saline control response0.10.10.1-0.3-0.3-0.2
Bone: connectivity density0.30.50.6-0.7-0.7-0.8
Bone: cortical apparent density7.610.110.93.33.32.9
Bone: cortical area0.00.00.0-0.2-0.1-0.2
Bone: cortical porosity0.30.30.4-0.6-0.6-0.3
Bone: cortical porosity0.70.70.9-0.9-1.0-0.6
Bone: cortical thickness0.20.40.50.70.70.6
Bone: cortical thickness0.00.00.0-0.1-0.1-0.0
Bone: cortical tissue density7.49.810.63.23.32.9
Condit. Reinf. active minus inactive responses0.10.10.10.30.30.2
Condit. Reinf. active-inactive response ratio0.00.00.0-0.1-0.2-0.2
Condit. Reinf. active responses0.30.30.40.60.60.5
Condit. Reinf. inactive responses0.50.60.70.80.80.7
Incentive salience index mean0.00.10.10.30.3-0.0
Condit. Reinf. lever presses0.20.20.30.60.60.2
Condit. Reinf. active minus inactive responses2.53.13.91.61.62.0
Condit. Reinf. active-inactive response ratio1.21.21.91.00.91.4
Condit. Reinf. active responses2.12.93.41.61.61.8
Condit. Reinf. inactive responses2.63.23.41.81.81.7
Condit. Reinf. lever presses1.62.22.5-1.6-1.6-1.3
Condit. Reinf. lever reinforcers received1.72.32.71.51.51.7
Conditioned reinforcement - actives1.91.92.21.51.51.2
Conditioned reinforcement - inactives1.51.72.01.41.41.0
Conditioned locomotion0.10.20.20.40.40.3
Patch foraging indifference point 0 sec6.29.911.3-3.0-3.0-3.4
Patch foraging indifference point AUC0.10.10.1-0.3-0.3-0.2
Delay disc. indifference point, 0s delay2.52.73.01.71.71.5
Delay disc. indifference point, 16s delay0.10.10.2-0.2-0.2-0.5
Delay disc. indifference point, 2s delay0.10.10.20.30.30.4
Delay disc. indifference point, 24s delay0.10.10.10.30.40.2
Delay disc. indifference point, 4s delay3.23.43.82.01.91.6
Delay disc. indifference point, 8s delay3.73.94.62.12.11.6
Indifference point function ln k0.40.60.7-0.7-0.7-0.8
Indifference point function log k0.40.60.7-0.7-0.7-0.8
Patch foraging total patch changes 0 sec5.18.39.4-2.8-2.8-3.1
Patch foraging total patch changes 12 sec0.60.80.8-0.9-0.9-0.9
Patch foraging total patch changes 18 sec1.31.71.8-1.3-1.3-1.3
Patch foraging total patch changes 24 sec0.60.80.9-0.8-0.9-0.9
Patch foraging total patch changes 6 sec1.42.12.7-1.3-1.3-1.7
Patch foraging time to switch 0 sec4.57.07.72.62.62.8
Patch foraging water rate 0 sec5.68.99.6-2.9-2.9-3.1
Patch foraging water rate 12 sec8.513.013.3-3.6-3.6-3.6
Patch foraging water rate 18 sec2.33.23.7-1.7-1.7-1.9
Patch foraging water rate 24 sec1.21.72.3-1.2-1.2-1.5
Patch foraging water rate 6 sec1.72.62.6-1.6-1.6-1.6
Seeking ratio, delayed vs. immediate footshock1.51.82.1-1.4-1.4-1.1
Distance traveled before self-admin0.60.61.0-0.7-0.7-1.0
Distance traveled after self-admin0.10.10.10.30.30.1
Extensor digitorum longus weight0.20.90.91.01.00.9
Bone: elastic displacement1.41.61.91.21.21.4
Bone: elastic work1.52.02.51.31.31.6
Bone: endosteal estimation1.02.22.4-1.5-1.6-1.4
Bone: endosteal perimeter0.91.92.0-1.4-1.4-1.3
Epididymis fat weight2.55.96.32.52.52.3
Delta time in closed arm before/after self-admin0.90.91.0-1.0-1.0-0.9
Delta time in open arm before/after self-admin0.10.10.2-0.3-0.3-0.5
Diff in mean of infusions in LGA sessions0.10.10.20.30.30.5
Delay discount exponential model param1.92.02.3-1.5-1.5-1.1
Extinction: sum of active levers before priming0.00.00.0-0.1-0.10.0
Active lever presses in extinction session 60.70.60.7-0.8-0.8-0.8
Bone: final force0.00.10.10.20.30.3
Bone: final moment0.10.10.1-0.3-0.3-0.3
Food consumed during 24 hour testing period0.10.10.1-0.4-0.3-0.1
Glucose0.00.00.00.00.0-0.2
Heart weight1.82.52.71.61.61.5
Delay discount hyperbolic model param1.81.92.2-1.5-1.5-1.1
Intermittent access intake day 1-15 change4.94.95.42.32.32.0
Intermittent access intake escalation5.25.15.52.32.32.1
Intermittent access intake escalation 23.93.84.02.02.01.9
Intermitt. access day 1 inactive lever presses1.82.02.5-1.3-1.3-1.6
Intermitt. access day 15 inactive lever presses0.40.40.60.60.60.8
Intermitt. access escalation Index0.10.10.2-0.3-0.3-0.4
Intermittent access day 1 total infusions0.10.10.1-0.3-0.3-0.2
Intermittent access day 15 total infusions1.61.81.91.41.41.3
Intermittent access terminal intake (last 3 days)0.91.01.11.01.01.0
Intermittent access total infusions0.30.30.30.60.50.5
Intermittent access day 1 locomotion0.60.60.7-0.8-0.8-0.7
Intermittent access day 15 total locomotion0.10.20.20.40.40.4
Intermittent access total locomotion0.10.10.2-0.4-0.4-0.2
Intermittent access standard deviation2.22.43.01.71.71.1
Left kidney weight0.00.00.10.20.20.1
Right kidney weight0.00.00.00.20.2-0.1
Cocaine induced anxiety0.20.20.30.50.50.3
Post-drug Anxiety1.11.31.31.11.11.2
Baseline Anxiety0.10.10.1-0.3-0.30.2
Tail length2.78.18.92.82.83.0
Length with tail1.14.14.52.12.11.9
Length without tail0.00.00.10.10.0-0.3
Times rat made contact with spout0.10.10.3-0.2-0.2-0.5
Lifetime Intake0.20.20.20.50.50.4
Liver weight, left2.13.43.61.91.91.7
Liver weight, right4.06.76.92.62.62.6
Locomotor activity0.00.00.1-0.1-0.1-0.3
Locomotor testing distance1.82.93.3-1.7-1.7-1.8
Locomotor testing rearing0.00.00.00.00.10.1
Locomotion in novel chamber0.20.30.4-0.5-0.4-0.6
Locomotion in novel chamber post-restriction0.20.20.2-0.4-0.4-0.5
Fecal boli incidents, locomotor time 10.10.10.10.20.20.4
Change in fecal boli incidents, locomotor task0.10.10.20.30.30.4
Time >=10cm from walls, locomotor time 10.00.00.00.10.1-0.2
Bouts of movement, locomotor time 10.30.40.5-0.7-0.7-0.5
Total resting periods, locomotor time 10.30.30.4-0.7-0.7-0.3
Rest time, locomotor task time 10.30.40.6-0.7-0.8-0.1
Distance moved, locomotor task time 10.20.20.20.50.50.4
Vertical activity count, locomotor time 10.10.10.2-0.2-0.2-0.5
Time >=10cm from walls, locomotor time 21.21.32.01.01.01.4
Bouts of movement, locomotor time 21.21.31.9-1.0-1.0-1.4
Total resting periods, locomotor time 21.21.31.7-1.0-1.0-1.3
Rest time, locomotor task time 20.10.20.2-0.5-0.5-0.2
Distance moved, locomotor task time 20.70.81.00.80.81.0
Vertical activity count, locomotor time 20.00.00.00.10.10.1
Light reinforcement 11.12.02.01.41.41.4
Light reinforcement 20.60.90.90.90.90.9
Bone: marrow area1.02.22.4-1.5-1.6-1.4
Bone: maximum diameter1.01.81.9-1.3-1.4-1.3
Bone: maximum force0.00.00.0-0.1-0.0-0.0
Bone: maximum moment0.30.50.6-0.8-0.7-0.7
Mean time between licks in bursts6.79.59.83.13.13.0
Mean num. licks in bursts0.10.10.10.20.20.3
Cd content in liver3.74.14.5-2.1-2.1-1.8
Co content in liver0.30.40.5-0.6-0.6-0.7
Cu content in liver0.00.00.00.10.10.1
Fe content in liver0.80.91.0-1.0-1.0-0.8
K content in liver2.12.12.21.41.41.5
Mg content in liver0.00.00.00.10.10.2
Mn content in liver0.40.50.50.70.70.6
Na content in liver5.96.26.32.52.52.5
Rb content in liver1.01.21.31.11.11.2
Se content in liver1.11.41.6-1.1-1.1-1.3
Sr content in liver0.50.40.5-0.6-0.6-0.7
Zn content in liver0.91.01.1-1.0-1.0-1.0
Bone: minimum diameter0.71.31.4-1.2-1.2-1.0
Time in familiar zone, hab. session 10.10.10.20.30.30.4
Time in novel zone, hab. session 13.02.93.4-1.6-1.6-1.9
Total zone transitions, hab. session 11.42.02.11.51.51.3
Total locomotion distance, hab. session 10.00.00.0-0.1-0.10.1
Locomotion velocity, hab. session 10.10.20.30.40.30.5
Time in familiar zone, hab. session 20.00.00.10.00.00.3
Time in novel zone, hab. session 20.20.20.4-0.3-0.3-0.6
Total zone transitions, hab. session 25.47.08.02.82.82.2
Total locomotion distance, hab. session 22.33.13.41.81.81.6
Locomotion velocity, hab. session 22.02.62.81.71.71.5
Novel to familiar place preference ratio2.72.83.1-1.6-1.6-1.8
Novelty place preference2.02.02.3-1.4-1.4-1.5
Time in novel zone, NPP test2.72.83.0-1.6-1.6-1.7
Total zone transitions, NPP test1.52.12.21.51.51.4
Total locomotion distance, NPP test0.00.00.10.20.10.3
Locomotion velocity, NPP test0.10.20.20.40.40.5
Intraocular pressure0.71.01.3-0.9-0.9-1.2
Delta distance traveled before/after self-admin0.30.30.40.60.60.5
Delta ambulatory time before/after self-admin0.50.60.70.80.80.6
Parametrial fat weight4.28.28.2-2.8-2.9-2.9
Pavlov. Cond. lever latency1.01.31.61.11.11.3
Pavlov. Cond. magazine entry latency0.70.90.90.91.00.9
Pavlov. Cond. change in total contacts0.20.20.3-0.3-0.3-0.6
Pavlov. Cond. index score0.00.00.10.00.0-0.3
Pavlov. Cond. latency score0.20.20.5-0.4-0.3-0.7
Pavlov. Cond. lever contacts0.20.20.5-0.3-0.3-0.7
Pavlov. Cond. magazine entry number0.91.11.3-1.1-1.1-0.9
Pavlov. Cond. intertrial magazine entries2.32.73.21.61.61.8
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.10.1-0.2
Pavlov. Cond. response bias0.40.40.60.70.80.4
Pavlov. Cond. lever latency0.60.81.01.01.00.7
Pavlov. Cond. magazine entry latency0.50.60.6-0.8-0.8-0.8
Pavlov. Cond. change in total contacts1.01.31.4-1.2-1.2-1.1
Pavlov. Cond. index score0.70.90.9-1.0-0.9-0.9
Pavlov. Cond. latency score0.60.80.9-0.9-0.9-0.8
Pavlov. Cond. lever contacts1.41.92.1-1.5-1.5-1.2
Pavlov. Cond. magazine entry number0.10.10.10.30.20.3
Pavlov. Cond. intertrial magazine entries4.45.75.82.42.42.4
Pavlov. Cond. lever-magazine prob. diff.0.70.80.9-0.9-0.9-0.9
Pavlov. Cond. response bias0.60.80.9-1.0-0.9-0.7
Time in closed arm before self-admin0.00.00.1-0.0-0.0-0.2
Time in closed arm after self-admin2.02.02.1-1.4-1.4-1.4
Time in open arm before self-admin0.10.10.30.30.30.5
Time in open arm after self-admin0.30.30.3-0.6-0.6-0.5
Bone: periosteal estimation0.81.61.7-1.3-1.3-1.2
Bone: periosteal perimeter0.20.30.3-0.5-0.5-0.4
Bone: post-yield work2.93.94.1-2.0-2.0-1.9
Progressive ratio test 1 active lever presses2.62.72.81.61.61.7
Progressive ratio test 1 breakpoint3.63.74.11.91.92.0
Progressive ratio test 1 inactive lever presses2.72.93.01.71.71.7
Progressive ratio test 2 active lever presses1.41.51.61.21.21.2
Progressive ratio test 2 breakpoint1.01.21.21.11.11.1
Progressive ratio test 2 inactive lever presses1.01.11.21.11.11.0
Incentive Sensitization - Responses0.20.20.20.40.40.3
Incentive Sensitization - Breakpoint0.20.20.20.40.40.3
Sum of active levers in priming session hrs 5-60.00.00.00.10.10.2
Progressive ratio2.42.82.91.71.71.6
Food seeking constrained by brief footshock3.64.44.72.22.12.0
Seeking ratio, punishment vs. effort0.00.00.0-0.0-0.0-0.1
Retroperitoneal fat weight0.41.21.51.21.20.8
Reaction time number correct0.00.10.1-0.2-0.2-0.3
Reaction time mean minus median0.20.30.60.40.40.8
Reaction time mean minus median AUC0.30.40.60.50.50.8
Reaction time num false alarms0.50.60.70.80.80.7
Reaction time num false alarms AUC0.30.40.40.70.70.5
Reaction time trials correct on left0.00.10.1-0.2-0.2-0.3
Reaction time trials on left0.10.10.2-0.3-0.3-0.4
Reaction time mean0.30.40.6-0.8-0.8-0.3
Reaction time mean AUC0.10.20.3-0.5-0.6-0.0
Median of all reaction times0.70.91.2-1.1-1.1-0.6
Reaction time omissions0.50.70.8-0.9-0.9-0.7
Reaction time false alarm rate0.20.20.30.50.50.4
Reaction time premature initiation rate0.00.10.10.20.20.3
Reaction time premature initiations0.00.10.10.20.20.2
Std. dev. reaction times0.20.30.4-0.6-0.6-0.2
Reaction time trials completed0.10.10.2-0.3-0.3-0.4
Reaction time trials AUC0.10.10.1-0.3-0.3-0.3
Run reversals in cocaine runway, females0.00.00.00.10.1-0.0
Run reversals in cocaine runway, males0.10.10.10.20.20.3
Latency to leave start box in cocaine runway0.30.30.4-0.6-0.6-0.4
Latency to leave start box in cocaine runway, F0.00.00.10.00.00.3
Latency to leave start box in cocaine runway, M0.10.10.1-0.4-0.4-0.3
Std. dev. time between licks in bursts0.00.10.1-0.2-0.3-0.2
Total sessions with >9 infusions2.02.22.51.61.51.3
Short access day 1 total inactive lever presses0.50.50.8-0.6-0.6-0.9
Short access day 10 total inactive lever presses0.91.11.1-1.0-1.0-1.1
Short access day 1 total infusions0.30.30.40.60.70.2
Short access day 10 total infusions0.00.00.00.20.20.1
Short access total infusions0.00.00.10.20.20.1
Short access day 1 locomotion0.10.10.10.40.40.2
Short access day 10 total locomotion0.40.50.9-0.5-0.5-0.9
Short access total locomotion0.10.10.20.40.40.2
One hour access (0.3 mA shock)0.81.01.11.01.10.9
Compulsive drug intake4.34.34.8-2.2-2.2-1.8
One hour access (shock baseline)3.74.34.52.12.12.0
Social response proportion0.10.10.1-0.3-0.3-0.4
Social responses1.21.62.01.21.21.4
Social time0.20.30.50.50.40.7
Soleus weight0.30.91.11.01.00.8
Bone: stiffness0.00.00.0-0.2-0.1-0.1
Tibialis anterior weight7.726.226.9-5.2-5.2-5.0
Time to tail flick, vehicle, before self-admin1.11.11.2-1.0-1.0-1.1
Time to tail flick, vehicle, after self-admin1.11.21.3-1.1-1.1-1.0
Time to tail flick, test, before self-admin0.10.10.30.20.2-0.5
Time to tail flick, test, after self-admin0.60.60.9-0.9-1.0-0.3
Delta time to tail flick, vehicle, before/after SA0.00.00.00.10.10.2
Delta time to tail flick, test, before/after SA0.80.71.1-1.0-1.1-0.1
Tibia length0.71.92.91.21.21.7
Ambulatory time before self-admin0.80.81.1-0.9-0.8-1.0
Ambulatory time after self-admin0.20.20.3-0.5-0.5-0.5
Bone: tissue strength0.00.00.1-0.1-0.1-0.3
Total heroin consumption0.60.70.70.80.80.9
Bone: trabecular number1.11.71.81.31.31.2
Bone: trabecular spacing0.60.81.0-1.0-1.0-0.7
Bone: trabecular thickness0.00.00.00.10.10.2
Bone: trabecular tissue density15.421.722.24.74.74.6
Water consumed over 24 hours1.21.41.8-1.1-1.1-1.4
Number of responses in last shaping day0.30.30.40.60.60.4