Hub : Genes

Pinx1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Pinx1 0.06 0.05 5.9e-03 0.02 0.03 0.04 0.03 2.6e-02 6.5e-03 3.9e-03 9.5e-03
2 Brain gene expression Pinx1 0.1 0.06 4.9e-05 0.04 0.06 0.04 0.04 1.7e-04 4.7e-06 3.1e-04 6.3e-05
3 Liver gene expression Pinx1 0.09 0.05 5.2e-08 0.04 0.06 0.06 0.06 6.9e-05 7.4e-07 6.2e-07 7.9e-07
4 PL isoform ratio XM_006252181.5 0.03 0.02 3.0e-03 0 0.02 0 0.01 1.0e-01 3.1e-03 1.1e-01 3.2e-02
5 pVTA gene expression Pinx1 0.11 0.06 3.4e-08 0.06 0.07 0.06 0.07 1.1e-05 1.4e-06 6.1e-06 2.8e-06
6 Adipose gene expression Pinx1 0.17 0.11 2.8e-15 0.11 0.12 0.12 0.11 1.2e-12 1.5e-13 1.0e-13 1.7e-12
7 Liver intron excision ratio chr15_42277237_42277640 0.03 0.02 4.3e-03 0.02 0.02 0 0.01 3.5e-03 6.5e-03 8.6e-02 1.5e-02
8 PL gene expression Pinx1 0.09 0.06 1.2e-06 0.05 0.04 0.04 0.04 2.0e-06 5.8e-05 2.4e-05 1.4e-05
9 Liver mRNA stability Pinx1 0.03 0.03 1.5e-03 0.01 0.01 0.01 0.01 2.1e-02 1.5e-02 4.8e-02 1.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.71.34.0-0.7-0.80.1-1.60.10.6-1.70.82.0
Area under the delay curve4.04.611.72.22.21.73.41.40.73.00.7-2.1
BMI with tail0.51.74.21.21.32.11.41.21.60.90.8-0.2
BMI without tail0.00.10.2-0.2-0.20.4-0.3-0.0-0.0-0.4-0.10.4
Body weight1.04.38.02.52.42.81.32.52.60.31.80.8
Weight adjusted by age1.62.44.12.01.51.9-0.21.81.9-0.91.51.4
Bone surface0.61.13.3-0.5-0.6-0.0-1.40.21.0-1.50.81.8
Bone volume0.30.51.8-0.3-0.50.1-0.80.20.9-0.90.61.3
Breakpoint value in progressive ratio session0.50.61.51.20.80.61.20.6-0.50.70.4-0.9
Number of licking bursts0.40.61.80.90.40.30.80.0-1.30.8-0.1-1.1
Context. condit. distance diff. score2.83.37.0-1.5-1.8-1.40.8-2.1-2.31.6-2.7-1.7
Locomotion velocity, session 10.40.41.20.60.40.70.10.9-0.2-0.61.10.5
Locomotion distance, session 10.40.51.50.30.10.3-0.50.80.3-1.21.01.1
Locomotion velocity, session 20.60.71.50.80.41.20.51.1-0.7-0.51.20.6
Locomotion distance, session 21.41.95.80.4-0.10.8-1.31.1-0.4-2.41.72.1
Locomotion velocity, session 30.81.02.11.41.11.20.11.40.2-0.41.10.7
Locomotion distance, session 30.10.20.30.50.50.40.50.50.10.3-0.1-0.2
Stereotopy head waving bouts, day 30.40.52.00.0-0.0-0.4-1.4-0.1-0.1-1.20.60.6
Stereotopy head waving duration, day 30.50.61.51.20.90.4-0.60.7-0.0-0.71.10.3
Locomotion velocity, session 71.31.43.2-1.5-1.8-0.60.0-1.2-1.70.2-1.6-0.0
Locomotion distance, session 72.12.65.0-2.0-2.2-1.5-0.5-2.0-1.80.1-2.1-0.4
Stereotopy head waving bouts, day 71.51.74.52.11.51.60.31.71.0-0.21.40.7
Stereotopy head waving duration, day 71.92.35.92.42.01.70.61.91.50.21.40.4
Locomotion velocity, session 80.20.20.70.30.00.50.70.3-0.80.3-0.0-0.2
Locomotion distance, session 80.40.52.8-0.6-1.0-0.1-0.1-0.4-1.7-0.3-0.40.2
Degree of sensitization distance4.44.58.9-2.8-3.0-2.2-1.1-2.7-2.4-0.3-2.3-0.4
Degree of sensitization stereotypy1.21.34.02.01.31.31.21.30.60.70.5-0.1
Conditioned locomotion1.01.23.2-1.0-1.1-1.00.3-1.4-0.51.0-1.8-0.9
Cocaine response after cond. corrected3.54.28.8-1.2-0.8-1.61.7-2.1-0.73.0-2.8-2.9
Cocaine response after cond. not corrected2.73.27.2-1.0-0.5-1.41.6-1.8-0.22.7-2.4-2.7
Cocaine response before conditioning1.21.52.70.90.81.1-0.71.41.2-1.41.61.5
Saline control response0.40.61.60.50.5-0.2-0.90.7-0.2-1.31.10.6
Bone: connectivity density1.62.67.0-1.2-1.1-0.4-2.6-0.20.5-2.50.72.5
Bone: cortical apparent density0.81.13.2-0.20.4-0.61.1-0.60.21.7-1.2-1.8
Bone: cortical area0.50.82.60.80.80.61.60.50.51.30.1-1.1
Bone: cortical porosity1.31.42.61.61.51.31.41.20.81.00.9-0.4
Bone: cortical porosity1.11.22.81.71.41.11.11.30.90.71.0-0.1
Bone: cortical thickness1.01.74.91.31.20.92.20.7-0.31.70.0-1.7
Bone: cortical thickness2.22.67.3-0.00.30.12.7-0.2-1.52.4-1.0-2.6
Bone: cortical tissue density0.81.13.2-0.30.3-0.61.1-0.70.11.7-1.3-1.8
Condit. Reinf. active minus inactive responses0.91.02.01.00.61.1-0.31.40.5-1.11.21.3
Condit. Reinf. active-inactive response ratio0.10.10.2-0.3-0.0-0.3-0.5-0.00.0-0.4-0.00.3
Condit. Reinf. active responses0.91.22.41.30.81.30.01.50.4-0.91.31.1
Condit. Reinf. inactive responses0.40.51.41.20.60.90.21.00.2-0.40.90.6
Incentive salience index mean2.42.95.72.01.72.40.62.41.2-0.62.11.2
Condit. Reinf. lever presses2.84.09.12.42.03.01.22.61.6-0.12.30.9
Condit. Reinf. active minus inactive responses0.30.31.2-1.1-0.7-0.7-0.3-0.6-0.6-0.2-0.1-0.2
Condit. Reinf. active-inactive response ratio0.10.10.3-0.6-0.30.1-0.4-0.1-0.5-0.50.30.3
Condit. Reinf. active responses0.30.41.4-1.2-0.9-0.7-0.3-0.8-0.3-0.1-0.3-0.1
Condit. Reinf. inactive responses0.60.81.7-1.3-1.3-1.2-0.6-1.1-0.6-0.3-0.8-0.0
Condit. Reinf. lever presses1.52.04.30.50.41.3-1.21.20.6-2.02.12.1
Condit. Reinf. lever reinforcers received0.10.10.5-0.7-0.5-0.3-0.2-0.4-0.4-0.30.1-0.0
Conditioned reinforcement - actives2.54.39.8-3.1-2.5-2.6-1.8-2.5-0.8-0.8-2.10.1
Conditioned reinforcement - inactives1.01.54.5-0.8-0.9-1.0-2.1-0.5-0.8-2.10.01.1
Conditioned locomotion3.44.47.9-2.8-1.7-2.30.5-2.5-1.71.7-2.5-2.1
Patch foraging indifference point 0 sec0.61.12.20.50.60.7-0.81.11.0-1.41.51.4
Patch foraging indifference point AUC1.11.62.5-1.5-0.9-1.20.6-1.4-1.31.3-1.4-1.6
Delay disc. indifference point, 0s delay0.10.10.5-0.40.2-0.00.50.00.70.6-0.0-0.2
Delay disc. indifference point, 16s delay2.83.08.51.61.30.52.90.50.22.9-0.1-2.4
Delay disc. indifference point, 2s delay0.50.51.00.30.90.61.00.60.90.90.4-0.5
Delay disc. indifference point, 24s delay3.03.410.31.11.20.93.20.5-0.43.2-0.1-2.5
Delay disc. indifference point, 4s delay3.53.77.02.62.32.12.41.91.11.71.5-1.0
Delay disc. indifference point, 8s delay3.84.410.62.42.21.93.31.50.62.90.6-2.0
Indifference point function ln k1.01.74.11.31.41.60.41.52.0-0.21.30.8
Indifference point function log k1.01.74.11.31.41.60.41.52.0-0.21.30.8
Patch foraging total patch changes 0 sec0.71.22.50.81.11.0-0.31.31.4-1.01.61.1
Patch foraging total patch changes 12 sec0.20.30.70.50.20.3-0.00.6-0.8-0.60.80.2
Patch foraging total patch changes 18 sec0.60.91.8-1.2-0.9-1.30.1-1.2-0.70.5-1.1-0.9
Patch foraging total patch changes 24 sec0.00.10.2-0.20.2-0.3-0.20.10.2-0.30.50.0
Patch foraging total patch changes 6 sec0.10.10.5-0.20.10.1-0.20.1-0.7-0.40.20.0
Patch foraging time to switch 0 sec0.10.21.30.5-0.30.1-0.3-0.0-1.1-0.50.10.2
Patch foraging water rate 0 sec0.40.93.40.61.20.70.90.91.90.70.5-0.2
Patch foraging water rate 12 sec0.20.51.90.60.90.40.70.71.40.50.3-0.1
Patch foraging water rate 18 sec1.52.24.81.62.01.51.51.52.21.10.8-0.4
Patch foraging water rate 24 sec0.20.30.60.60.00.10.80.10.40.8-0.8-0.3
Patch foraging water rate 6 sec0.71.15.40.51.40.20.80.82.30.70.5-0.5
Seeking ratio, delayed vs. immediate footshock0.20.31.7-0.2-0.2-0.10.2-0.21.30.5-0.70.3
Distance traveled before self-admin0.40.53.2-0.70.1-0.4-0.5-0.11.8-0.1-0.10.5
Distance traveled after self-admin0.91.13.9-0.10.70.21.3-0.12.01.7-0.4-0.9
Extensor digitorum longus weight4.216.729.35.35.44.54.64.13.93.02.6-1.9
Bone: elastic displacement0.40.41.1-0.4-0.4-0.9-0.8-0.2-1.1-0.90.10.3
Bone: elastic work0.40.51.40.50.80.2-0.21.00.2-0.71.20.5
Bone: endosteal estimation0.20.51.6-0.3-0.4-0.1-0.80.20.9-0.80.41.3
Bone: endosteal perimeter0.51.02.3-0.9-0.9-0.5-1.4-0.31.0-1.30.31.5
Epididymis fat weight0.20.82.2-0.50.1-0.81.1-0.50.61.5-0.6-1.4
Delta time in closed arm before/after self-admin0.20.21.1-0.2-0.30.20.1-0.41.10.5-0.50.2
Delta time in open arm before/after self-admin0.10.10.30.00.5-0.0-0.00.3-0.6-0.10.6-0.2
Diff in mean of infusions in LGA sessions2.43.08.32.92.11.90.92.30.5-0.02.00.4
Delay discount exponential model param4.75.312.7-2.5-2.5-2.1-3.6-1.7-0.7-3.1-1.02.1
Extinction: sum of active levers before priming0.10.10.40.60.3-0.10.40.1-0.30.20.1-0.5
Active lever presses in extinction session 60.30.30.9-1.0-0.6-0.30.1-0.6-0.60.0-0.5-0.3
Bone: final force0.61.02.41.01.01.11.61.10.91.10.5-0.4
Bone: final moment0.61.01.41.11.11.11.21.21.20.70.80.0
Food consumed during 24 hour testing period0.20.30.60.30.30.1-0.60.50.7-0.60.70.8
Glucose0.20.31.50.30.20.10.70.1-1.20.40.1-0.8
Heart weight0.20.40.7-0.8-0.7-0.7-0.3-0.80.40.2-0.8-0.1
Delay discount hyperbolic model param4.04.510.4-2.3-2.3-2.0-3.2-1.6-0.7-2.7-1.11.9
Intermittent access intake day 1-15 change0.61.22.5-1.1-1.3-1.2-1.2-1.1-1.6-0.8-0.80.3
Intermittent access intake escalation0.30.61.4-0.7-0.8-0.7-0.9-0.7-1.2-0.7-0.40.2
Intermittent access intake escalation 20.30.41.4-0.5-0.6-0.6-0.6-0.7-1.2-0.2-0.5-0.1
Intermitt. access day 1 inactive lever presses0.10.61.3-1.1-0.6-0.3-1.2-0.2-0.1-1.0-0.31.0
Intermitt. access day 15 inactive lever presses0.61.22.3-0.00.71.0-1.10.81.4-1.51.01.3
Intermitt. access escalation Index0.10.10.3-0.4-0.4-0.0-0.1-0.1-0.6-0.3-0.20.2
Intermittent access day 1 total infusions0.40.71.4-1.2-0.7-1.1-0.1-1.1-0.20.3-0.8-1.0
Intermittent access day 15 total infusions1.11.73.1-1.6-1.5-1.5-1.1-1.5-1.8-0.7-1.0-0.3
Intermittent access terminal intake (last 3 days)1.41.84.4-1.5-1.5-1.6-1.1-1.5-2.1-0.8-0.9-0.4
Intermittent access total infusions2.02.33.8-1.9-1.7-1.8-0.7-1.9-1.9-0.1-1.5-0.9
Intermittent access day 1 locomotion0.20.20.80.10.50.10.6-0.00.20.60.1-0.9
Intermittent access day 15 total locomotion0.61.12.0-1.4-0.8-1.4-0.5-1.3-1.20.0-0.9-0.9
Intermittent access total locomotion0.20.30.7-0.8-0.3-0.6-0.1-0.7-0.50.2-0.3-0.8
Intermittent access standard deviation0.51.14.9-0.4-1.0-0.9-1.1-0.6-2.2-1.2-0.10.2
Left kidney weight0.94.08.61.82.02.50.22.42.9-0.62.01.8
Right kidney weight1.57.017.62.42.73.10.13.14.2-0.82.52.3
Cocaine induced anxiety0.81.21.91.11.31.40.91.31.30.41.10.1
Post-drug Anxiety1.61.74.61.01.41.4-0.11.52.1-0.61.51.0
Baseline Anxiety0.10.20.50.40.2-0.0-0.60.20.1-0.70.40.4
Tail length0.31.33.90.0-0.1-0.2-1.80.40.5-2.00.71.8
Length with tail0.52.23.61.81.31.2-0.61.91.4-1.31.61.8
Length without tail1.54.810.13.22.72.61.72.72.10.81.90.4
Times rat made contact with spout0.30.31.00.2-0.10.8-0.30.6-0.2-0.60.61.0
Lifetime Intake1.62.03.3-1.7-1.6-1.7-0.7-1.8-1.8-0.2-1.3-0.8
Liver weight, left1.32.14.61.91.71.30.21.72.1-0.31.60.7
Liver weight, right0.71.32.31.21.50.41.50.80.81.30.6-1.3
Locomotor activity2.94.57.62.52.42.30.52.72.7-0.72.41.4
Locomotor testing distance1.22.24.60.70.80.7-1.21.51.9-1.91.72.1
Locomotor testing rearing2.95.915.80.60.30.8-2.91.91.4-4.02.54.0
Locomotion in novel chamber0.40.51.21.10.71.00.11.00.1-0.40.80.5
Locomotion in novel chamber post-restriction0.30.52.70.8-0.10.40.60.5-1.7-0.10.10.1
Fecal boli incidents, locomotor time 10.10.20.5-0.1-0.3-0.10.6-0.3-0.20.7-0.6-0.4
Change in fecal boli incidents, locomotor task0.50.51.70.40.10.3-0.90.5-0.4-1.30.81.0
Time >=10cm from walls, locomotor time 11.11.13.30.30.20.3-1.30.90.8-1.70.91.8
Bouts of movement, locomotor time 10.40.51.40.90.11.00.40.7-1.2-0.20.60.5
Total resting periods, locomotor time 10.40.53.30.3-0.30.50.70.1-1.80.3-0.1-0.1
Rest time, locomotor task time 10.40.53.10.1-0.50.60.7-0.1-1.80.4-0.5-0.2
Distance moved, locomotor task time 10.20.31.0-0.5-0.1-1.0-0.8-0.30.7-0.50.00.1
Vertical activity count, locomotor time 10.30.74.50.10.8-0.9-0.40.12.1-0.00.5-0.3
Time >=10cm from walls, locomotor time 20.40.62.1-0.10.10.0-0.90.41.4-0.80.21.2
Bouts of movement, locomotor time 21.01.63.71.51.31.31.91.1-0.11.50.7-0.9
Total resting periods, locomotor time 21.22.14.51.81.51.62.11.3-0.31.61.0-1.0
Rest time, locomotor task time 21.41.85.51.50.51.21.90.9-2.41.00.5-1.1
Distance moved, locomotor task time 20.60.72.8-0.7-0.2-1.2-0.8-0.71.7-0.0-0.70.1
Vertical activity count, locomotor time 21.01.46.1-0.90.2-1.4-0.1-0.92.51.0-0.8-0.9
Light reinforcement 10.20.51.30.90.60.90.10.90.4-0.41.10.6
Light reinforcement 20.30.51.0-0.6-0.6-0.70.3-1.0-0.20.8-0.9-0.9
Bone: marrow area0.20.41.5-0.3-0.5-0.1-0.80.10.8-0.80.31.2
Bone: maximum diameter0.30.51.50.10.2-0.21.2-0.10.31.2-0.4-1.1
Bone: maximum force0.71.33.31.01.21.11.81.11.01.30.6-0.7
Bone: maximum moment0.71.32.01.11.31.11.41.31.40.90.9-0.3
Mean time between licks in bursts1.02.54.9-2.0-1.9-1.6-2.2-1.6-0.3-1.3-1.11.3
Mean num. licks in bursts0.50.72.3-0.9-0.60.0-0.90.11.2-1.00.31.5
Cd content in liver2.42.76.11.31.11.0-1.31.81.0-2.02.52.1
Co content in liver0.80.92.11.40.91.11.40.70.31.00.4-0.7
Cu content in liver1.11.33.51.40.91.90.41.40.8-0.41.31.0
Fe content in liver0.70.92.4-0.7-0.9-0.9-1.5-0.5-0.6-1.30.01.0
K content in liver0.30.30.9-0.7-0.6-0.4-0.2-0.90.00.4-0.8-0.4
Mg content in liver1.21.22.6-1.6-1.5-1.1-1.3-1.2-0.3-0.8-0.80.7
Mn content in liver0.80.92.0-1.4-1.3-1.1-0.6-1.30.2-0.1-1.2-0.0
Na content in liver5.25.610.23.23.12.91.12.91.9-0.13.10.3
Rb content in liver0.80.92.5-1.1-0.8-0.8-1.6-0.6-0.4-1.30.01.0
Se content in liver0.20.30.80.40.20.1-0.70.20.9-0.60.50.7
Sr content in liver1.21.02.7-0.4-0.30.1-1.60.20.5-1.70.91.6
Zn content in liver0.70.82.1-0.4-0.50.0-1.4-0.00.6-1.30.71.5
Bone: minimum diameter0.20.30.60.40.50.60.70.70.80.30.6-0.1
Time in familiar zone, hab. session 10.40.40.7-0.8-0.8-0.50.5-0.8-0.40.5-0.8-0.7
Time in novel zone, hab. session 10.70.71.81.31.30.60.41.0-0.60.10.8-0.3
Total zone transitions, hab. session 10.20.30.90.50.40.21.00.5-0.20.50.0-0.5
Total locomotion distance, hab. session 10.10.10.5-0.4-0.2-0.30.20.1-0.7-0.20.1-0.1
Locomotion velocity, hab. session 10.10.10.2-0.10.10.10.00.50.2-0.40.40.4
Time in familiar zone, hab. session 20.60.71.4-0.5-0.6-1.00.2-1.0-0.90.7-1.2-0.8
Time in novel zone, hab. session 20.50.51.20.50.20.7-0.30.8-0.2-1.11.10.8
Total zone transitions, hab. session 20.50.71.61.30.71.10.51.00.9-0.10.50.6
Total locomotion distance, hab. session 20.20.20.60.60.20.80.60.60.50.10.20.3
Locomotion velocity, hab. session 20.40.51.21.00.61.10.70.90.60.20.50.3
Novel to familiar place preference ratio0.50.61.9-0.6-0.80.0-0.6-0.0-1.4-1.20.40.7
Novelty place preference0.70.72.0-0.4-0.70.3-0.80.2-1.2-1.40.71.1
Time in novel zone, NPP test0.70.82.3-0.2-0.50.4-0.80.4-1.2-1.50.81.2
Total zone transitions, NPP test0.20.30.70.3-0.00.80.10.60.6-0.30.40.8
Total locomotion distance, NPP test0.91.22.9-1.0-1.3-0.2-1.5-0.3-0.3-1.7-0.11.7
Locomotion velocity, NPP test0.81.12.4-1.1-1.4-0.3-1.3-0.4-0.3-1.5-0.31.5
Intraocular pressure2.94.29.2-1.9-2.0-2.0-3.0-1.2-1.9-2.90.11.7
Delta distance traveled before/after self-admin0.70.71.70.90.80.71.30.5-0.61.10.3-1.0
Delta ambulatory time before/after self-admin0.40.51.40.40.50.21.10.1-0.81.0-0.1-1.2
Parametrial fat weight1.33.17.7-1.7-2.4-2.0-1.2-1.8-2.8-0.8-1.50.2
Pavlov. Cond. lever latency1.51.85.1-1.5-1.3-2.3-1.2-1.5-1.3-0.5-1.3-0.3
Pavlov. Cond. magazine entry latency0.81.02.31.31.11.50.31.30.4-0.31.30.6
Pavlov. Cond. change in total contacts2.93.05.82.22.02.41.42.30.90.12.10.2
Pavlov. Cond. index score3.34.19.52.52.33.11.62.41.80.52.00.4
Pavlov. Cond. latency score2.63.38.32.22.02.91.32.21.50.31.90.5
Pavlov. Cond. lever contacts1.92.36.51.81.52.61.31.71.30.41.50.4
Pavlov. Cond. magazine entry number2.12.65.6-2.3-1.9-2.4-1.0-2.1-0.9-0.1-1.7-0.4
Pavlov. Cond. intertrial magazine entries0.20.21.60.10.1-0.0-0.10.21.3-0.10.10.4
Pavlov. Cond. lever-magazine prob. diff.3.64.410.12.62.43.21.72.51.90.72.00.3
Pavlov. Cond. response bias2.12.65.62.11.92.41.51.81.30.81.4-0.0
Pavlov. Cond. lever latency2.43.37.9-1.7-1.5-1.90.8-2.1-1.31.8-2.8-1.9
Pavlov. Cond. magazine entry latency1.21.43.92.01.61.31.01.40.60.41.1-0.1
Pavlov. Cond. change in total contacts1.62.65.02.02.21.70.32.11.5-0.62.10.6
Pavlov. Cond. index score2.02.75.12.22.01.80.32.11.3-0.62.30.8
Pavlov. Cond. latency score2.12.85.12.22.01.90.22.01.5-0.72.30.9
Pavlov. Cond. lever contacts2.43.37.61.81.61.9-0.72.11.2-1.82.71.8
Pavlov. Cond. magazine entry number0.40.61.6-1.3-0.9-0.8-0.8-0.8-0.1-0.4-0.60.2
Pavlov. Cond. intertrial magazine entries3.75.610.0-3.1-3.2-2.1-3.1-2.0-1.5-2.4-1.02.1
Pavlov. Cond. lever-magazine prob. diff.1.82.44.62.12.01.80.51.91.2-0.32.10.4
Pavlov. Cond. response bias2.12.86.02.21.81.90.02.10.9-1.12.41.2
Time in closed arm before self-admin1.01.33.41.01.51.50.91.21.80.70.70.1
Time in closed arm after self-admin1.21.35.30.70.51.11.20.32.31.5-0.60.2
Time in open arm before self-admin0.70.81.4-0.3-1.1-0.9-1.1-0.6-1.0-1.2-0.20.7
Time in open arm after self-admin0.60.62.1-0.1-0.1-0.3-1.20.1-0.6-1.50.90.7
Bone: periosteal estimation0.10.10.60.10.10.10.40.20.80.30.10.1
Bone: periosteal perimeter0.00.10.4-0.0-0.10.10.00.10.6-0.10.20.3
Bone: post-yield work3.04.49.1-1.2-1.0-1.52.3-1.7-1.42.9-2.6-3.0
Progressive ratio test 1 active lever presses0.60.83.7-0.6-0.9-0.8-0.3-0.8-1.9-0.4-0.5-0.5
Progressive ratio test 1 breakpoint0.50.63.2-0.5-0.7-0.7-0.1-0.7-1.8-0.2-0.4-0.7
Progressive ratio test 1 inactive lever presses0.71.02.7-1.1-0.7-0.7-1.6-0.40.2-1.6-0.10.9
Progressive ratio test 2 active lever presses0.80.92.1-0.9-0.9-0.6-1.4-0.6-1.0-1.5-0.10.7
Progressive ratio test 2 breakpoint0.60.72.3-0.6-0.7-0.3-1.4-0.3-0.8-1.50.10.8
Progressive ratio test 2 inactive lever presses1.22.04.3-1.8-1.4-1.1-2.1-1.1-0.8-1.9-0.71.0
Incentive Sensitization - Responses0.91.23.8-0.7-0.3-0.1-1.90.10.6-2.00.51.6
Incentive Sensitization - Breakpoint1.11.54.6-0.6-0.3-0.0-2.00.20.7-2.20.71.8
Sum of active levers in priming session hrs 5-60.20.10.3-0.3-0.3-0.50.1-0.4-0.40.1-0.5-0.5
Progressive ratio0.40.61.31.21.10.60.20.70.90.10.9-0.1
Food seeking constrained by brief footshock1.11.32.7-0.8-0.5-0.70.8-1.3-0.41.6-1.6-1.6
Seeking ratio, punishment vs. effort0.60.91.7-0.9-0.6-0.50.8-1.0-0.51.2-1.3-1.1
Retroperitoneal fat weight0.10.41.3-0.5-1.1-0.4-0.2-0.5-0.9-0.2-0.80.5
Reaction time number correct0.30.51.2-0.7-0.6-0.3-1.1-0.20.1-1.10.01.1
Reaction time mean minus median0.41.01.81.30.60.9-0.51.1-0.8-1.11.30.8
Reaction time mean minus median AUC0.20.61.10.70.40.6-0.70.7-0.4-1.01.00.9
Reaction time num false alarms1.21.72.61.41.11.6-0.21.61.4-0.91.61.4
Reaction time num false alarms AUC0.91.42.41.21.01.50.01.41.6-0.61.31.2
Reaction time trials correct on left0.30.51.2-0.7-0.6-0.3-1.1-0.20.1-1.10.01.1
Reaction time trials on left0.30.61.4-0.8-0.7-0.3-1.2-0.30.1-1.2-0.01.1
Reaction time mean0.20.30.90.2-0.1-0.1-0.9-0.0-0.9-0.7-0.20.6
Reaction time mean AUC0.10.20.80.30.20.0-0.90.2-0.3-0.70.10.7
Median of all reaction times0.20.30.7-0.1-0.2-0.4-0.9-0.3-0.7-0.4-0.60.5
Reaction time omissions1.72.56.1-2.0-1.8-1.1-2.5-1.3-0.8-1.8-0.51.5
Reaction time false alarm rate0.91.22.31.41.21.50.81.31.30.21.10.3
Reaction time premature initiation rate0.20.20.50.50.40.30.70.5-0.60.40.1-0.4
Reaction time premature initiations0.00.10.6-0.1-0.10.00.10.2-0.8-0.1-0.10.1
Std. dev. reaction times0.20.51.60.3-0.20.2-0.80.2-1.3-1.00.40.6
Reaction time trials completed0.30.61.4-0.8-0.7-0.3-1.2-0.30.1-1.2-0.01.1
Reaction time trials AUC0.40.71.7-0.9-0.8-0.4-1.3-0.30.1-1.3-0.01.2
Run reversals in cocaine runway, females0.10.10.3-0.1-0.5-0.5-0.1-0.4-0.3-0.0-0.2-0.2
Run reversals in cocaine runway, males2.32.44.62.12.01.61.51.80.30.51.9-0.8
Latency to leave start box in cocaine runway1.31.54.3-2.1-1.4-1.4-1.4-1.1-0.2-1.0-0.70.8
Latency to leave start box in cocaine runway, F0.30.40.9-0.9-0.4-0.4-0.9-0.1-0.2-0.90.30.7
Latency to leave start box in cocaine runway, M1.21.12.1-1.4-1.3-1.3-1.2-1.10.7-0.7-0.90.8
Std. dev. time between licks in bursts0.81.12.9-1.1-1.1-1.0-1.7-0.8-0.1-1.2-0.51.1
Total sessions with >9 infusions0.40.51.4-1.2-0.6-0.8-0.8-0.90.3-0.2-0.60.0
Short access day 1 total inactive lever presses0.10.10.4-0.2-0.4-0.40.1-0.2-0.60.0-0.3-0.2
Short access day 10 total inactive lever presses0.20.51.6-1.3-0.8-0.8-0.4-0.8-0.3-0.1-0.80.1
Short access day 1 total infusions1.52.04.4-2.1-1.8-1.7-1.0-1.9-1.0-0.3-1.5-0.3
Short access day 10 total infusions0.10.10.7-0.2-0.1-0.60.3-0.3-0.10.3-0.2-0.8
Short access total infusions0.40.61.1-0.9-0.8-1.0-0.3-1.0-0.7-0.0-0.7-0.6
Short access day 1 locomotion0.40.52.4-0.8-0.2-0.4-0.2-0.61.50.2-0.6-0.1
Short access day 10 total locomotion0.10.20.70.20.50.5-0.00.30.80.10.30.1
Short access total locomotion0.10.10.80.10.50.3-0.10.20.9-0.00.30.0
One hour access (0.3 mA shock)0.91.04.0-0.7-1.1-1.1-0.1-1.1-2.0-0.0-0.7-1.0
Compulsive drug intake0.20.20.50.60.10.7-0.00.5-0.1-0.40.50.7
One hour access (shock baseline)0.91.43.3-1.1-1.3-1.6-0.7-1.3-1.8-0.6-0.8-0.7
Social response proportion1.92.14.1-1.7-2.0-1.0-1.6-1.3-1.8-1.0-1.21.0
Social responses2.02.55.0-1.8-2.2-1.2-1.8-1.4-2.0-1.4-1.01.2
Social time1.92.68.40.80.01.2-1.91.10.7-2.41.32.9
Soleus weight0.61.85.20.20.7-0.11.9-0.40.72.3-1.0-2.2
Bone: stiffness1.01.63.01.21.31.61.61.11.71.20.7-0.3
Tibialis anterior weight4.816.430.75.55.34.84.04.33.92.43.1-1.2
Time to tail flick, vehicle, before self-admin0.80.92.11.41.11.01.01.10.00.50.8-0.4
Time to tail flick, vehicle, after self-admin0.50.71.71.30.80.90.71.0-0.9-0.00.8-0.2
Time to tail flick, test, before self-admin0.10.10.50.2-0.20.1-0.40.2-0.1-0.60.20.7
Time to tail flick, test, after self-admin3.03.15.8-2.2-2.3-1.7-2.4-1.7-0.9-1.9-0.91.2
Delta time to tail flick, vehicle, before/after SA0.30.30.7-0.6-0.8-0.3-0.7-0.4-0.5-0.8-0.10.5
Delta time to tail flick, test, before/after SA1.71.83.9-2.0-1.6-1.4-1.7-1.5-0.4-1.1-1.00.6
Tibia length3.39.015.92.92.33.1-1.23.52.8-2.74.03.6
Ambulatory time before self-admin0.20.31.7-0.5-0.1-0.4-0.0-0.21.30.2-0.30.2
Ambulatory time after self-admin1.21.43.70.31.20.51.70.31.91.8-0.1-1.1
Bone: tissue strength0.40.41.2-0.7-0.4-0.7-1.1-0.20.0-0.90.20.7
Total heroin consumption0.30.41.01.00.80.50.60.6-0.40.00.7-0.5
Bone: trabecular number1.01.64.5-0.9-0.90.0-1.9-0.00.6-1.90.92.1
Bone: trabecular spacing2.12.77.61.11.40.32.50.10.52.6-0.8-2.8
Bone: trabecular thickness0.60.81.61.10.71.30.41.20.4-0.21.10.7
Bone: trabecular tissue density1.82.64.71.52.20.92.11.01.52.00.4-1.8
Water consumed over 24 hours0.91.21.91.41.21.30.31.41.1-0.21.40.6
Number of responses in last shaping day0.40.51.50.90.60.10.90.2-0.40.80.2-1.2