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chr2:225,664,331-228,461,478

Best TWAS P=2.838249e-09 · Best GWAS P=1.667995e-10 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Rap1gds1	gene expression	ENSRNOG00000015987	0.28	0.24	enet	236	0.26	1.5e-28	5.7	5.2	1.6e-07	-0.84	0.66	0.34	TRUE
2	Adipose	Dnajb14	gene expression	ENSRNOG00000060107	0.25	0.20	enet	76	0.23	2.7e-25	-4.9	-5.4	6.4e-08	0.66	0.64	0.36	TRUE
3	Adipose	Rap1gds1	mRNA stability	ENSRNOG00000015987	0.13	0.06	blup	2505	0.10	1.3e-11	3.5	5.7	1.0e-08	-0.79	0.60	0.40	TRUE
4	BLA	Metap1	gene expression	ENSRNOG00000012947	0.08	0.03	top1	1	0.03	9.1e-03	-5.6	-5.6	2.6e-08	0.75	0.13	0.07	TRUE
5	BLA	Eif4e	gene expression	ENSRNOG00000052343	0.11	0.04	lasso	6	0.04	2.9e-03	-6.1	5.4	6.7e-08	-0.88	0.20	0.73	FALSE
6	Brain	Trmt10a	gene expression	ENSRNOG00000011025	0.46	0.27	enet	300	0.36	1.9e-34	4.3	5.2	2.3e-07	-0.56	0.96	0.04	FALSE
7	Brain	Rap1gds1	gene expression	ENSRNOG00000015987	0.43	0.47	enet	237	0.52	7.2e-56	-6.2	5.6	2.7e-08	-0.94	0.14	0.86	FALSE
8	Brain	Trmt10a	mRNA stability	ENSRNOG00000011025	0.08	0.01	enet	27	0.04	7.2e-05	-4.8	-5.9	4.2e-09	0.44	0.51	0.48	TRUE
9	Eye	Rap1gds1	gene expression	ENSRNOG00000015987	0.43	0.23	top1	1	0.23	2.2e-04	-5.8	5.8	5.1e-09	-0.96	0.14	0.06	FALSE
10	LHb	Tspan5	gene expression	ENSRNOG00000015913	0.26	0.10	enet	51	0.17	9.9e-05	-5.9	5.6	2.7e-08	-0.88	0.38	0.53	FALSE
11	LHb	Stpg2	gene expression	ENSRNOG00000023457	0.20	0.11	blup	2587	0.11	1.6e-03	-5.8	5.9	4.8e-09	-0.92	0.37	0.49	FALSE
12	Liver	Mttp	gene expression	ENSRNOG00000010655	0.31	0.20	lasso	42	0.25	5.8e-28	-4.8	5.3	1.5e-07	-0.76	0.64	0.36	FALSE
13	Liver	Rap1gds1	gene expression	ENSRNOG00000015987	0.25	0.23	top1	1	0.23	3.8e-25	5.7	5.7	1.3e-08	-0.91	0.59	0.41	FALSE
14	Liver	Adh7	gene expression	ENSRNOG00000032959	0.55	0.39	lasso	9	0.39	1.8e-45	-4.9	-5.3	1.1e-07	0.76	0.44	0.56	FALSE
15	NAcc	Rap1gds1	mRNA stability	ENSRNOG00000015987	0.22	0.16	top1	1	0.16	2.5e-04	-5.9	5.9	2.8e-09	-0.93	0.13	0.07	TRUE
16	OFC	Tspan5	isoform ratio	ENSRNOT00000021381	0.23	0.09	lasso	2	0.21	1.1e-05	-5.8	-5.7	1.6e-08	0.94	0.26	0.56	FALSE
17	PL2	Rap1gds1	gene expression	ENSRNOG00000015987	0.41	0.24	top1	1	0.24	3.7e-13	-5.7	5.7	1.3e-08	-0.94	0.59	0.41	FALSE
18	PL2	Tspan5	isoform ratio	ENSRNOT00000021381	0.31	0.26	top1	1	0.26	3.6e-14	5.3	-5.3	1.0e-07	0.61	0.76	0.24	FALSE
19	PL2	Tspan5	isoform ratio	ENSRNOT00000111381	0.25	0.20	top1	1	0.20	2.5e-11	5.3	5.3	1.2e-07	-0.68	0.78	0.22	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.