Best TWAS P=2.89e-08 · Best GWAS P=2.33e-08 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Slc35a1 | gene expression | ENSRNOG00000008908 | 0.11 | 1 | 0.05 | 1.1e-06 | 5.35 | 8.92e-08 | 0.92 | FALSE |
| Adipose | RGD1359108 | gene expression | ENSRNOG00000009478 | 0.13 | 1 | 0.06 | 1.9e-07 | -5.3 | 1.13e-07 | 0.71 | FALSE |
| Adipose | Rars2 | intron excision ratio | chr5:49210334:49211494 | 0.03 | 1 | 0.02 | 1.2e-03 | 5.21 | 1.85e-07 | 0.07 | TRUE |
| BLA | RGD1359108 | gene expression | ENSRNOG00000009478 | 0.08 | 1 | 0.05 | 9.6e-04 | -5.17 | 2.35e-07 | 0.04 | FALSE |
| BLA | RGD1359108 | mRNA stability | ENSRNOG00000009478 | 0.11 | 22 | 0.07 | 1.8e-04 | 5.31 | 1.08e-07 | 0.7 | TRUE |
| Brain | Rars2 | intron excision ratio | chr5:49195892:49196811 | 0.03 | 1563 | 0.02 | 4.7e-03 | -5.22 | 1.78e-07 | 0.39 | FALSE |
| Brain | Slc35a1 | mRNA stability | ENSRNOG00000008908 | 0.08 | 1548 | 0.06 | 2.5e-06 | 5.15 | 2.59e-07 | 0.49 | FALSE |
| Brain | RGD1359108 | mRNA stability | ENSRNOG00000009478 | 0.16 | 1015 | 0.12 | 3.0e-11 | 5.25 | 1.55e-07 | 0.74 | FALSE |
| IL | Rars2 | isoform ratio | ENSRNOT00000011688 | 0.16 | 3 | 0.15 | 1.7e-04 | -5.12 | 3.09e-07 | 0.36 | FALSE |
| IL | Rars2 | isoform ratio | ENSRNOT00000115962 | 0.15 | 4 | 0.13 | 4.5e-04 | 5.14 | 2.77e-07 | 0.35 | FALSE |
| Liver | Slc35a1 | isoform ratio | ENSRNOT00000081150 | 0.04 | 1548 | 0.01 | 1.8e-02 | -5.22 | 1.82e-07 | 0.37 | TRUE |
| Liver | Rars2 | intron excision ratio | chr5:49222641:49232932 | 0.03 | 18 | 0.01 | 4.3e-02 | 5.43 | 5.51e-08 | 0.39 | FALSE |
| NAcc | RGD1359108 | gene expression | ENSRNOG00000009478 | 0.08 | 1 | 0.05 | 1.5e-04 | 5.31 | 1.09e-07 | 0.13 | FALSE |
| NAcc | Slc35a1 | intron excision ratio | chr5:49226632:49230692 | 0.04 | 2 | 0.03 | 2.3e-03 | -5.19 | 2.16e-07 | 0.48 | FALSE |
| NAcc | RGD1359108 | mRNA stability | ENSRNOG00000009478 | 0.17 | 20 | 0.08 | 1.0e-06 | 5.28 | 1.27e-07 | 0.74 | FALSE |
| OFC | RGD1359108 | gene expression | ENSRNOG00000009478 | 0.29 | 1 | 0.08 | 5.7e-03 | 5.37 | 7.69e-08 | 0.06 | FALSE |
| PL | RGD1359108 | gene expression | ENSRNOG00000009478 | 0.2 | 1 | 0.07 | 1.0e-05 | 5.3 | 1.13e-07 | 0.51 | FALSE |
| PL | Smim8 | intron excision ratio | chr5:49337089:49338917 | 0.07 | 1 | 0.04 | 6.5e-04 | -5.17 | 2.35e-07 | 0.07 | TRUE |
| PL | RGD1359108 | mRNA stability | ENSRNOG00000009478 | 0.08 | 1 | 0.05 | 2.0e-04 | 5.55 | 2.89e-08 | 0.61 | TRUE |