Hub : Traits : Tibialis anterior weight : ← →

chr5:48,482,122-49,968,409

Trait: Tibialis anterior weight

Best TWAS P=2.887081e-08 · Best GWAS P=2.331361e-08 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Slc35a1	gene expression	ENSRNOG00000008908	0.11	0.05	top1	1	0.05	1.1e-06	5.3	5.3	8.9e-08	0.83	0.07	0.92	FALSE
2	Adipose	RGD1359108	gene expression	ENSRNOG00000009478	0.13	0.06	top1	1	0.06	1.9e-07	5.3	-5.3	1.1e-07	-0.86	0.26	0.71	FALSE
3	Adipose	Rars2	intron excision ratio	chr5:49210334:49211494	0.03	0.02	top1	1	0.02	1.2e-03	5.2	5.2	1.8e-07	0.80	0.05	0.07	TRUE
4	BLA	RGD1359108	gene expression	ENSRNOG00000009478	0.08	0.05	top1	1	0.05	9.6e-04	5.2	-5.2	2.3e-07	-0.54	0.04	0.04	FALSE
5	BLA	RGD1359108	mRNA stability	ENSRNOG00000009478	0.11	0.06	lasso	22	0.07	1.8e-04	5.3	5.3	1.1e-07	-0.87	0.27	0.70	TRUE
6	Brain	Rars2	intron excision ratio	chr5:49195892:49196811	0.03	0.01	blup	1563	0.02	4.7e-03	4.9	-5.2	1.8e-07	-0.85	0.42	0.39	FALSE
7	Brain	Slc35a1	mRNA stability	ENSRNOG00000008908	0.08	0.05	blup	1548	0.06	2.5e-06	4.8	5.2	2.6e-07	0.88	0.51	0.49	FALSE
8	Brain	RGD1359108	mRNA stability	ENSRNOG00000009478	0.16	0.11	blup	1015	0.12	3.0e-11	5.3	5.2	1.6e-07	0.98	0.26	0.74	FALSE
9	IL	Rars2	isoform ratio	ENSRNOT00000011688	0.16	0.07	enet	3	0.15	1.7e-04	4.9	-5.1	3.1e-07	-0.87	0.41	0.36	FALSE
10	IL	Rars2	isoform ratio	ENSRNOT00000115962	0.15	0.07	enet	4	0.13	4.5e-04	4.9	5.1	2.8e-07	0.87	0.39	0.35	FALSE
11	Liver	Slc35a1	isoform ratio	ENSRNOT00000081150	0.04	0.00	blup	1548	0.01	1.8e-02	4.9	-5.2	1.8e-07	-0.87	0.35	0.37	TRUE
12	Liver	Rars2	intron excision ratio	chr5:49222641:49232932	0.03	0.01	enet	18	0.01	4.3e-02	5.4	5.4	5.5e-08	0.89	0.40	0.39	FALSE
13	NAcc	RGD1359108	gene expression	ENSRNOG00000009478	0.08	0.05	top1	1	0.05	1.5e-04	5.3	5.3	1.1e-07	0.98	0.06	0.13	FALSE
14	NAcc	Slc35a1	intron excision ratio	chr5:49226632:49230692	0.04	0.03	lasso	2	0.03	2.3e-03	5.1	-5.2	2.2e-07	-0.83	0.44	0.48	FALSE
15	NAcc	RGD1359108	mRNA stability	ENSRNOG00000009478	0.17	0.08	lasso	20	0.08	1.0e-06	5.3	5.3	1.3e-07	0.99	0.26	0.74	FALSE
16	OFC	RGD1359108	gene expression	ENSRNOG00000009478	0.29	0.08	top1	1	0.08	5.7e-03	5.4	5.4	7.7e-08	0.61	0.05	0.06	FALSE
17	PL	RGD1359108	gene expression	ENSRNOG00000009478	0.20	0.07	top1	1	0.07	1.0e-05	5.3	5.3	1.1e-07	0.99	0.19	0.51	FALSE
18	PL	Smim8	intron excision ratio	chr5:49337089:49338917	0.07	0.04	top1	1	0.04	6.5e-04	5.2	-5.2	2.3e-07	-0.75	0.07	0.07	TRUE
19	PL	RGD1359108	mRNA stability	ENSRNOG00000009478	0.08	0.05	top1	1	0.05	2.0e-04	5.5	5.5	2.9e-08	0.97	0.07	0.61	TRUE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.