Hub : Genes

Krt71

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Krt71	0.21	0.11	6.4e-14	0.11	0.11	0.12	0.11	2.4e-12	2.6e-12	1.1e-12	2.4e-12
2	LHb	gene expression	Krt71	0.21	0.14	7.6e-04	0.2	0.15	0.19	0.2	1.9e-05	2.0e-04	3.2e-05	2.1e-05
3	NAcc	mRNA stability	Krt71	0.03	0.02	3.8e-04	0.03	0.02	0.02	0.02	4.0e-04	1.6e-03	1.0e-03	1.2e-03
4	NAcc	gene expression	Krt71	0.09	0.03	0.0e+00	0.19	0.18	0.19	0.19	5.0e-22	1.3e-20	1.5e-21	1.5e-21

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.3	0.4	1.5	1.2	0.0	-0.3	-0.3
Area under the delay curve	0.3	0.3	0.5	0.7	0.5	-0.5	-0.6
BMI with tail	2.6	8.5	14.4	3.8	1.6	-3.0	-2.9
BMI without tail	0.5	1.1	2.6	1.6	0.4	-0.9	-0.8
Body weight	0.6	2.6	4.7	2.2	0.2	-1.6	-1.7
Weight adjusted by age	0.7	0.8	1.3	1.0	-0.6	-1.1	-0.8
Bone surface	0.7	1.2	3.7	1.9	0.7	-0.6	-0.6
Bone volume	0.7	1.3	3.4	1.8	0.7	-0.7	-0.8
Breakpoint value in progressive ratio session	0.9	1.0	1.9	1.4	1.4	-0.2	0.1
Number of licking bursts	0.3	0.4	0.9	-0.9	0.7	-0.1	-0.2
Context. condit. distance diff. score	0.1	0.1	0.3	0.3	0.5	0.3	0.2
Locomotion velocity, session 1	6.0	6.5	9.1	-3.0	-2.3	2.5	2.3
Locomotion distance, session 1	1.3	1.7	2.8	-1.7	-1.5	1.0	0.9
Locomotion velocity, session 2	3.4	3.9	5.5	-2.0	-2.4	1.7	1.8
Locomotion distance, session 2	1.3	1.9	2.9	-1.7	-1.4	1.2	1.1
Locomotion velocity, session 3	6.3	7.3	9.1	-3.0	-2.5	2.7	2.6
Locomotion distance, session 3	5.0	5.5	6.2	-2.2	-2.2	2.5	2.5
Stereotopy head waving bouts, day 3	1.8	2.1	2.4	1.4	1.5	-1.5	-1.4
Stereotopy head waving duration, day 3	0.0	0.0	0.1	0.1	0.3	-0.3	-0.1
Locomotion velocity, session 7	1.2	1.3	2.6	-1.6	-0.2	1.1	1.2
Locomotion distance, session 7	3.1	3.9	4.7	-2.1	-1.7	2.0	2.2
Stereotopy head waving bouts, day 7	2.8	3.2	3.8	1.5	1.7	-1.9	-2.0
Stereotopy head waving duration, day 7	2.5	3.0	3.7	1.5	1.9	-1.7	-1.8
Locomotion velocity, session 8	0.2	0.3	0.6	-0.7	-0.1	0.6	0.5
Locomotion distance, session 8	1.7	2.6	3.0	-1.7	-1.4	1.7	1.6
Degree of sensitization distance	0.6	0.6	0.7	0.7	0.9	-0.9	-0.8
Degree of sensitization stereotypy	2.3	2.5	3.1	1.3	1.8	-1.6	-1.7
Conditioned locomotion	0.3	0.4	0.9	-0.1	-0.9	0.5	0.5
Cocaine response after cond. corrected	0.1	0.1	0.3	-0.0	-0.2	-0.5	-0.5
Cocaine response after cond. not corrected	0.1	0.1	0.1	-0.4	-0.4	-0.2	-0.2
Cocaine response before conditioning	1.2	1.5	2.1	-1.4	-0.6	1.3	1.3
Saline control response	0.0	0.0	0.1	-0.3	0.2	0.2	0.2
Bone: connectivity density	0.1	0.1	0.2	0.3	-0.4	0.4	0.4
Bone: cortical apparent density	1.2	1.6	2.6	0.6	0.9	-1.6	-1.6
Bone: cortical area	0.8	1.2	2.8	1.7	0.6	-0.9	-0.9
Bone: cortical porosity	1.5	1.6	2.1	-0.9	-1.2	1.4	1.5
Bone: cortical porosity	1.4	1.5	1.9	-0.9	-1.2	1.3	1.4
Bone: cortical thickness	0.2	0.3	0.7	0.8	0.1	-0.6	-0.6
Bone: cortical thickness	0.9	1.0	2.7	-0.8	-1.6	0.6	0.5
Bone: cortical tissue density	1.0	1.3	2.3	0.5	0.7	-1.5	-1.5
Condit. Reinf. active minus inactive responses	0.4	0.4	0.5	-0.5	-0.7	0.7	0.6
Condit. Reinf. active-inactive response ratio	0.4	0.5	0.7	-0.6	-0.7	0.8	0.7
Condit. Reinf. active responses	0.9	1.1	1.7	-0.8	-1.3	1.0	1.0
Condit. Reinf. inactive responses	0.9	1.1	2.0	-1.0	-1.4	0.8	0.8
Incentive salience index mean	0.1	0.1	0.1	-0.2	-0.3	0.3	0.2
Condit. Reinf. lever presses	0.4	0.5	0.7	0.6	0.6	-0.8	-0.8
Condit. Reinf. active minus inactive responses	1.2	1.4	1.7	1.0	1.3	-1.2	-1.3
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.7	0.7	0.7	-0.7	-0.8
Condit. Reinf. active responses	1.1	1.6	2.8	0.8	1.7	-1.1	-1.3
Condit. Reinf. inactive responses	0.1	0.2	0.5	-0.2	0.7	-0.3	-0.3
Condit. Reinf. lever presses	0.3	0.4	0.6	-0.7	-0.2	0.8	0.7
Condit. Reinf. lever reinforcers received	0.4	0.5	1.2	0.2	1.1	-0.6	-0.7
Conditioned reinforcement - actives	0.6	0.6	1.0	-0.8	1.0	-0.6	-0.7
Conditioned reinforcement - inactives	0.0	0.0	0.2	-0.4	-0.0	0.1	-0.0
Conditioned locomotion	0.2	0.2	0.6	-0.8	0.6	0.1	0.1
Patch foraging indifference point 0 sec	0.5	0.8	2.1	-1.4	-0.0	0.8	0.6
Patch foraging indifference point AUC	0.4	0.5	0.9	0.2	0.6	-0.9	-0.9
Delay disc. indifference point, 0s delay	0.2	0.3	0.3	0.6	-0.3	-0.5	-0.6
Delay disc. indifference point, 16s delay	0.5	0.5	0.8	0.8	0.9	-0.6	-0.4
Delay disc. indifference point, 2s delay	5.6	6.2	7.4	2.3	2.5	-2.4	-2.7
Delay disc. indifference point, 24s delay	0.3	0.3	0.5	0.5	0.6	-0.7	-0.4
Delay disc. indifference point, 4s delay	0.2	0.3	0.5	0.7	0.3	-0.1	-0.7
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.1	-0.0	0.3	0.3
Indifference point function ln k	0.3	0.4	1.1	1.1	-0.4	0.4	0.3
Indifference point function log k	0.3	0.4	1.1	1.1	-0.4	0.4	0.3
Patch foraging total patch changes 0 sec	0.9	1.5	3.1	-1.8	-0.5	1.3	1.1
Patch foraging total patch changes 12 sec	0.3	0.4	1.5	-1.2	0.3	0.2	-0.0
Patch foraging total patch changes 18 sec	0.7	0.9	3.0	-1.7	0.3	0.3	0.6
Patch foraging total patch changes 24 sec	0.2	0.2	0.8	-0.2	0.9	-0.1	0.0
Patch foraging total patch changes 6 sec	0.3	0.4	1.5	-1.2	0.4	0.1	-0.1
Patch foraging time to switch 0 sec	0.2	0.2	0.3	-0.5	0.4	-0.5	-0.5
Patch foraging water rate 0 sec	0.1	0.1	0.2	0.4	0.1	0.4	0.2
Patch foraging water rate 12 sec	0.7	1.0	2.1	-0.1	-0.9	1.1	1.4
Patch foraging water rate 18 sec	0.0	0.0	0.1	-0.0	0.3	0.3	0.0
Patch foraging water rate 24 sec	0.3	0.5	1.0	1.0	0.6	-0.5	-0.4
Patch foraging water rate 6 sec	0.2	0.3	0.8	0.3	-0.1	0.6	0.9
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.8	0.9	-0.0	-0.7	-0.1
Distance traveled before self-admin	0.1	0.1	0.2	-0.3	0.3	-0.1	-0.4
Distance traveled after self-admin	0.7	0.8	1.5	-1.2	-0.1	1.1	0.7
Extensor digitorum longus weight	7.8	30.7	42.7	6.5	4.5	-5.6	-5.4
Bone: elastic displacement	5.4	6.1	6.6	-2.6	-2.2	2.5	2.5
Bone: elastic work	2.8	3.6	5.2	-1.5	-2.3	1.9	1.8
Bone: endosteal estimation	0.7	1.5	4.2	2.1	0.8	-0.7	-0.7
Bone: endosteal perimeter	1.1	2.2	5.0	2.2	1.0	-1.2	-1.2
Epididymis fat weight	2.9	6.8	12.5	-1.5	-3.5	2.4	2.5
Delta time in closed arm before/after self-admin	0.6	0.6	1.4	1.2	0.8	-0.2	-0.4
Delta time in open arm before/after self-admin	4.0	3.9	4.6	-2.1	-2.1	1.6	2.1
Diff in mean of infusions in LGA sessions	1.1	1.2	2.5	1.6	0.2	-1.1	-1.1
Delay discount exponential model param	0.4	0.4	0.5	-0.7	-0.6	0.6	0.7
Extinction: sum of active levers before priming	1.1	1.1	2.7	1.6	0.7	-0.9	-0.8
Active lever presses in extinction session 6	0.2	0.2	0.5	0.7	0.4	-0.2	-0.3
Bone: final force	0.4	0.7	2.4	1.5	0.3	-0.3	-0.4
Bone: final moment	0.5	0.8	2.9	1.7	0.3	-0.3	-0.4
Food consumed during 24 hour testing period	0.6	0.7	1.1	-0.5	-0.6	1.0	1.1
Glucose	0.1	0.2	0.7	0.0	-0.8	0.2	0.4
Heart weight	0.0	0.1	0.2	0.1	0.0	-0.4	-0.2
Delay discount hyperbolic model param	0.7	0.8	0.9	-1.0	-0.9	0.8	0.9
Intermittent access intake day 1-15 change	0.7	0.7	1.0	-0.9	-0.1	1.0	1.0
Intermittent access intake escalation	0.6	0.6	0.8	-0.9	0.3	0.9	0.9
Intermittent access intake escalation 2	0.3	0.3	0.4	-0.6	0.2	0.7	0.6
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.6	0.6	0.8	-0.3	-0.4
Intermitt. access day 15 inactive lever presses	0.5	0.6	0.8	-0.2	-0.8	0.8	0.9
Intermitt. access escalation Index	1.7	1.5	3.4	0.6	1.8	-1.1	-1.0
Intermittent access day 1 total infusions	0.2	0.2	0.6	-0.5	0.8	-0.2	-0.2
Intermittent access day 15 total infusions	0.5	0.6	1.5	-1.2	0.5	0.5	0.5
Intermittent access terminal intake (last 3 days)	0.6	0.7	2.1	-0.8	1.4	-0.1	-0.1
Intermittent access total infusions	0.7	0.7	2.5	-0.5	1.6	-0.3	-0.3
Intermittent access day 1 locomotion	0.6	0.6	1.8	-1.3	0.5	0.5	0.5
Intermittent access day 15 total locomotion	0.8	0.9	1.5	-0.9	-0.2	1.1	1.2
Intermittent access total locomotion	0.5	0.6	1.2	-1.1	0.7	0.5	0.5
Intermittent access standard deviation	0.7	0.7	1.0	-1.0	-0.8	0.8	0.7
Left kidney weight	0.1	0.3	0.5	0.5	0.1	-0.7	-0.7
Right kidney weight	0.3	0.9	1.2	1.0	0.4	-1.1	-1.1
Cocaine induced anxiety	0.1	0.2	0.2	-0.1	0.4	0.5	0.5
Post-drug Anxiety	1.0	1.1	2.5	1.2	1.6	-0.5	-0.4
Baseline Anxiety	0.4	0.5	1.4	1.2	0.3	-0.5	-0.4
Tail length	0.4	1.2	1.8	-1.4	-0.9	1.1	1.0
Length with tail	0.1	0.5	1.0	-0.8	-1.0	0.5	0.3
Length without tail	0.1	0.2	0.3	0.4	-0.2	-0.5	-0.5
Times rat made contact with spout	0.8	0.9	1.1	-1.0	-0.6	1.0	1.0
Lifetime Intake	0.5	0.6	1.8	-0.8	1.3	0.0	0.0
Liver weight, left	0.1	0.1	0.3	0.0	-0.1	0.5	0.4
Liver weight, right	0.1	0.2	0.3	0.3	-0.0	0.5	0.5
Locomotor activity	0.1	0.1	0.3	-0.5	-0.3	0.3	0.2
Locomotor testing distance	0.8	1.4	2.7	-1.7	-0.6	1.2	1.0
Locomotor testing rearing	0.4	0.6	1.0	-1.0	-0.8	0.8	0.5
Locomotion in novel chamber	2.3	2.9	4.0	2.0	1.0	-1.9	-1.7
Locomotion in novel chamber post-restriction	0.9	1.1	1.9	1.0	1.4	-0.9	-0.7
Fecal boli incidents, locomotor time 1	3.9	4.2	5.2	-2.3	-1.6	2.2	2.1
Change in fecal boli incidents, locomotor task	1.5	1.5	2.4	1.5	0.9	-1.3	-0.9
Time >=10cm from walls, locomotor time 1	0.5	0.5	0.8	-0.7	-0.2	0.8	0.9
Bouts of movement, locomotor time 1	0.3	0.3	1.0	-1.0	-0.3	0.3	0.3
Total resting periods, locomotor time 1	0.9	0.9	1.8	-1.4	-0.8	0.8	0.8
Rest time, locomotor task time 1	0.8	0.9	1.9	-1.4	-0.3	0.9	0.8
Distance moved, locomotor task time 1	1.4	1.5	2.1	1.5	1.2	-1.3	-1.0
Vertical activity count, locomotor time 1	2.6	2.8	3.5	1.5	1.5	-1.9	-1.8
Time >=10cm from walls, locomotor time 2	0.5	0.5	1.2	-1.1	0.1	0.8	0.5
Bouts of movement, locomotor time 2	1.9	2.0	2.9	1.2	1.7	-1.4	-1.3
Total resting periods, locomotor time 2	2.7	2.9	3.7	1.5	1.9	-1.7	-1.6
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.4	0.1	0.0	0.3
Distance moved, locomotor task time 2	0.1	0.1	0.1	0.3	-0.3	-0.0	-0.2
Vertical activity count, locomotor time 2	0.2	0.2	0.6	0.1	0.1	-0.4	-0.7
Light reinforcement 1	0.2	0.3	0.9	-0.9	0.5	-0.3	-0.1
Light reinforcement 2	0.1	0.2	0.6	-0.8	-0.2	-0.2	0.2
Bone: marrow area	0.7	1.4	4.1	2.0	0.8	-0.7	-0.6
Bone: maximum diameter	0.5	0.9	1.2	1.1	0.9	-0.8	-0.8
Bone: maximum force	1.0	1.6	4.3	2.1	0.8	-0.9	-0.9
Bone: maximum moment	1.0	1.8	5.1	2.3	0.7	-0.8	-0.9
Mean time between licks in bursts	1.4	1.9	3.0	-1.7	-0.9	1.4	1.3
Mean num. licks in bursts	0.8	1.0	1.8	0.1	-1.3	1.0	1.1
Cd content in liver	0.5	0.5	1.2	-1.1	0.1	0.7	0.5
Co content in liver	0.1	0.1	0.5	0.2	0.7	0.1	0.1
Cu content in liver	1.1	1.3	4.9	0.5	2.2	-0.1	-0.2
Fe content in liver	0.1	0.2	0.6	-0.8	0.1	0.0	0.1
K content in liver	0.4	0.3	0.8	-0.9	-0.2	0.6	0.5
Mg content in liver	0.7	0.7	1.7	-1.3	0.0	0.8	0.8
Mn content in liver	0.0	0.0	0.1	-0.1	-0.4	-0.0	-0.2
Na content in liver	0.1	0.1	0.3	-0.4	0.6	0.1	0.0
Rb content in liver	0.5	0.7	1.0	-0.7	1.0	0.8	0.7
Se content in liver	0.6	0.8	2.1	-1.4	-0.7	0.5	0.5
Sr content in liver	1.3	1.2	1.7	-0.4	-1.2	1.1	1.3
Zn content in liver	2.2	2.4	4.0	-2.0	-0.7	1.5	1.7
Bone: minimum diameter	1.2	2.2	5.3	2.3	0.8	-1.2	-1.1
Time in familiar zone, hab. session 1	0.6	0.6	1.3	-0.4	-1.2	0.7	0.7
Time in novel zone, hab. session 1	2.3	2.3	3.4	1.2	1.8	-1.5	-1.4
Total zone transitions, hab. session 1	0.3	0.4	0.6	0.1	0.6	-0.7	-0.8
Total locomotion distance, hab. session 1	0.5	0.7	1.3	-1.1	-0.8	0.6	0.6
Locomotion velocity, hab. session 1	0.6	0.8	1.3	-1.1	-1.0	0.7	0.7
Time in familiar zone, hab. session 2	0.2	0.2	0.2	0.5	-0.3	0.3	0.5
Time in novel zone, hab. session 2	0.5	0.5	0.8	0.3	0.9	-0.8	-0.9
Total zone transitions, hab. session 2	0.3	0.4	0.8	-0.9	-0.6	0.5	0.6
Total locomotion distance, hab. session 2	0.5	0.6	1.4	-0.7	-1.2	0.6	0.6
Locomotion velocity, hab. session 2	0.8	1.0	2.2	-0.9	-1.5	0.8	0.8
Novel to familiar place preference ratio	1.0	1.0	1.3	1.1	0.7	-1.0	-1.1
Novelty place preference	0.6	0.6	0.8	0.9	0.6	-0.8	-0.9
Time in novel zone, NPP test	0.9	0.9	1.1	1.1	0.7	-1.0	-1.0
Total zone transitions, NPP test	1.1	1.6	3.7	-1.9	-1.1	1.0	0.8
Total locomotion distance, NPP test	2.4	3.3	4.9	-2.2	-2.1	1.4	1.4
Locomotion velocity, NPP test	2.8	4.0	5.4	-2.3	-2.3	1.6	1.5
Intraocular pressure	0.8	1.1	1.7	-1.3	-0.0	1.1	1.2
Delta distance traveled before/after self-admin	2.4	2.6	3.5	-1.4	-1.2	1.9	1.8
Delta ambulatory time before/after self-admin	2.1	2.3	3.3	-1.2	-1.2	1.8	1.8
Parametrial fat weight	4.0	7.7	10.9	-3.3	-2.3	2.9	2.5
Pavlov. Cond. lever latency	1.4	1.8	3.2	-1.1	-1.8	1.2	1.2
Pavlov. Cond. magazine entry latency	3.2	4.1	5.5	1.9	2.4	-1.9	-1.9
Pavlov. Cond. change in total contacts	3.3	3.6	4.9	1.9	2.2	-1.7	-1.6
Pavlov. Cond. index score	4.0	5.1	6.9	2.1	2.6	-2.1	-2.1
Pavlov. Cond. latency score	3.8	4.8	7.0	2.1	2.6	-2.0	-2.0
Pavlov. Cond. lever contacts	1.3	1.5	2.5	1.1	1.6	-1.1	-1.0
Pavlov. Cond. magazine entry number	1.5	1.9	2.6	-1.4	-1.6	1.2	1.1
Pavlov. Cond. intertrial magazine entries	2.0	2.5	3.4	-1.8	-1.4	1.5	1.4
Pavlov. Cond. lever-magazine prob. diff.	3.9	4.8	6.7	2.0	2.6	-2.1	-2.0
Pavlov. Cond. response bias	1.4	1.6	2.3	1.3	1.5	-1.3	-1.0
Pavlov. Cond. lever latency	1.2	1.6	2.2	1.5	0.7	-1.3	-1.4
Pavlov. Cond. magazine entry latency	2.3	2.6	3.7	-1.3	-1.9	1.6	1.6
Pavlov. Cond. change in total contacts	0.7	1.0	1.8	0.7	1.3	-0.9	-0.9
Pavlov. Cond. index score	1.6	2.1	2.3	-1.5	-1.3	1.5	1.5
Pavlov. Cond. latency score	1.5	1.8	2.1	-1.5	-1.2	1.4	1.4
Pavlov. Cond. lever contacts	2.2	3.0	3.4	-1.8	-1.3	1.8	1.8
Pavlov. Cond. magazine entry number	0.6	0.7	0.9	0.6	0.9	-0.9	-0.9
Pavlov. Cond. intertrial magazine entries	0.8	1.1	1.4	-0.9	-0.9	1.1	1.2
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	1.5	-1.1	-1.1	1.2	1.2
Pavlov. Cond. response bias	1.9	2.5	3.1	-1.5	-1.3	1.7	1.8
Time in closed arm before self-admin	0.3	0.3	0.8	-0.2	-0.0	-0.6	-0.9
Time in closed arm after self-admin	2.6	2.6	3.4	1.4	1.8	-1.5	-1.8
Time in open arm before self-admin	2.4	2.6	4.0	1.3	2.0	-1.4	-1.6
Time in open arm after self-admin	0.5	0.5	1.2	-0.7	-1.1	0.3	0.6
Bone: periosteal estimation	0.9	1.9	5.0	2.2	0.9	-1.0	-0.9
Bone: periosteal perimeter	2.3	3.8	7.4	2.7	1.3	-1.8	-1.8
Bone: post-yield work	0.8	1.0	2.4	1.5	0.9	-0.7	-0.6
Progressive ratio test 1 active lever presses	1.4	1.5	4.8	-2.2	0.5	0.7	0.6
Progressive ratio test 1 breakpoint	1.2	1.2	3.9	-2.0	0.6	0.6	0.5
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.5	-0.7	0.7	-0.1	-0.3
Progressive ratio test 2 active lever presses	0.4	0.4	1.3	-0.5	1.1	0.1	0.1
Progressive ratio test 2 breakpoint	0.3	0.3	1.3	-0.3	1.1	0.0	0.0
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.2	-0.5	0.5	0.4	0.4
Incentive Sensitization - Responses	0.3	0.3	0.8	0.9	0.5	-0.3	-0.3
Incentive Sensitization - Breakpoint	0.6	0.6	1.2	1.1	0.7	-0.5	-0.5
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.4	0.4	1.2	-0.7	-0.4
Progressive ratio	0.0	0.0	0.1	0.2	0.0	-0.3	-0.0
Food seeking constrained by brief footshock	0.6	0.7	2.0	-1.0	1.4	0.0	-0.2
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	-0.6	0.5	0.3	-0.0
Retroperitoneal fat weight	1.8	5.8	6.6	-2.5	-2.6	2.3	2.3
Reaction time number correct	1.3	1.9	2.5	-1.3	-1.0	1.6	1.6
Reaction time mean minus median	0.1	0.2	0.4	0.1	-0.2	-0.5	-0.6
Reaction time mean minus median AUC	0.3	0.4	0.7	0.3	0.3	-0.7	-0.8
Reaction time num false alarms	0.3	0.5	0.8	-0.9	-0.7	0.5	0.6
Reaction time num false alarms AUC	0.2	0.2	0.7	-0.9	-0.3	0.2	0.2
Reaction time trials correct on left	1.3	1.9	2.5	-1.3	-1.0	1.6	1.6
Reaction time trials on left	1.4	2.0	2.5	-1.3	-1.1	1.6	1.6
Reaction time mean	0.4	0.5	0.8	0.9	0.0	-0.8	-0.8
Reaction time mean AUC	0.4	0.6	1.0	1.0	0.0	-0.8	-0.9
Median of all reaction times	0.4	0.5	1.1	1.0	0.1	-0.7	-0.7
Reaction time omissions	0.7	0.9	2.5	-0.8	-1.6	0.6	0.5
Reaction time false alarm rate	0.3	0.4	0.7	0.1	0.6	-0.8	-0.8
Reaction time premature initiation rate	1.0	1.4	1.8	-1.4	-0.7	1.4	1.2
Reaction time premature initiations	2.3	3.2	4.1	-1.9	-1.3	2.0	1.9
Std. dev. reaction times	0.3	0.4	0.8	0.4	-0.2	-0.8	-0.9
Reaction time trials completed	1.4	2.0	2.5	-1.3	-1.1	1.6	1.6
Reaction time trials AUC	1.1	1.6	2.1	-1.1	-1.0	1.4	1.4
Run reversals in cocaine runway, females	0.1	0.1	0.2	0.4	-0.1	-0.1	-0.3
Run reversals in cocaine runway, males	1.5	1.5	3.3	0.8	0.1	-1.4	-1.8
Latency to leave start box in cocaine runway	0.5	0.5	0.9	0.7	0.9	-0.7	-0.5
Latency to leave start box in cocaine runway, F	0.3	0.4	0.6	0.3	0.7	-0.8	-0.6
Latency to leave start box in cocaine runway, M	0.7	0.7	1.2	1.1	1.1	-0.6	-0.1
Std. dev. time between licks in bursts	2.1	2.5	3.5	-1.9	-1.4	1.6	1.5
Total sessions with >9 infusions	0.9	1.0	3.2	0.0	1.8	-0.7	-0.5
Short access day 1 total inactive lever presses	0.2	0.2	0.3	-0.5	0.4	0.5	0.2
Short access day 10 total inactive lever presses	0.1	0.1	0.2	0.4	-0.0	0.5	0.3
Short access day 1 total infusions	0.1	0.1	0.2	-0.5	-0.0	0.1	-0.1
Short access day 10 total infusions	0.3	0.4	0.8	-0.8	0.9	0.1	0.2
Short access total infusions	0.2	0.3	0.5	-0.7	0.7	0.2	0.2
Short access day 1 locomotion	0.1	0.1	0.2	-0.5	-0.4	-0.0	-0.1
Short access day 10 total locomotion	0.0	0.0	0.1	-0.1	-0.0	-0.2	-0.1
Short access total locomotion	0.1	0.1	0.4	-0.6	0.2	-0.2	-0.2
One hour access (0.3 mA shock)	3.0	3.5	6.3	1.6	2.5	-1.7	-1.5
Compulsive drug intake	2.3	2.3	3.5	1.7	1.9	-1.3	-1.1
One hour access (shock baseline)	1.4	1.6	2.4	1.0	1.5	-1.2	-1.2
Social response proportion	1.2	1.3	1.6	-1.3	-1.1	1.1	1.1
Social responses	0.5	0.6	1.5	-1.2	-0.9	0.3	0.2
Social time	1.0	1.3	3.2	-0.7	-1.8	0.8	0.8
Soleus weight	0.1	0.4	1.4	1.2	-0.2	-0.2	-0.0
Bone: stiffness	2.6	4.2	7.7	2.8	1.7	-1.7	-1.7
Tibialis anterior weight	10.3	35.2	41.3	6.4	5.1	-6.1	-6.1
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.2	0.7	0.3	-0.9	-1.1
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.4	0.6	-0.3	-0.3	-0.1
Time to tail flick, test, before self-admin	0.4	0.4	1.1	0.2	-0.3	-0.6	-1.0
Time to tail flick, test, after self-admin	1.0	1.0	3.2	1.8	-0.0	-0.8	-0.5
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.0	-0.2	-0.4	0.7	1.0
Delta time to tail flick, test, before/after SA	0.6	0.5	1.9	1.4	0.2	-0.4	0.1
Tibia length	0.1	0.2	0.6	0.8	-0.1	-0.1	-0.2
Ambulatory time before self-admin	0.2	0.2	0.7	-0.3	0.8	-0.0	-0.1
Ambulatory time after self-admin	0.9	1.0	1.7	-1.0	0.1	1.3	1.1
Bone: tissue strength	1.9	1.8	2.7	1.7	1.4	-1.1	-1.1
Total heroin consumption	0.2	0.2	0.7	0.9	0.3	0.3	0.2
Bone: trabecular number	0.2	0.2	0.5	0.0	-0.7	0.6	0.5
Bone: trabecular spacing	0.6	0.8	2.2	0.3	1.5	-0.6	-0.7
Bone: trabecular thickness	0.1	0.1	0.2	0.2	-0.5	-0.2	-0.2
Bone: trabecular tissue density	1.6	2.3	3.1	0.9	1.5	-1.8	-1.7
Water consumed over 24 hours	0.6	0.8	1.3	-0.6	-0.7	1.0	1.1
Number of responses in last shaping day	1.5	1.5	3.5	-1.2	-1.9	0.8	0.6