Hub : Genes

Krt71

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Krt71 0.2 0.11 5.3e-13 0.1 0.1 0.11 0.1 3.3e-11 2.0e-11 6.0e-12 1.1e-11
2 NAcc gene expression Krt71 0.13 0.06 0.0e+00 0.17 0.17 0.16 0.18 1.0e-24 6.4e-25 4.1e-24 3.8e-26
3 LHb gene expression Krt71 0.24 0.16 4.6e-04 0.18 0.17 0.16 0.17 4.8e-05 9.6e-05 1.0e-04 7.1e-05
4 NAcc mRNA stability Krt71 0.03 0.02 4.0e-06 0.04 0.04 0.03 0.04 4.8e-06 7.7e-07 1.2e-05 2.5e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density0.20.30.6-0.70.8-0.10.4
Area under the delay curve0.10.20.3-0.40.5-0.20.5
BMI with tail2.07.09.7-3.12.8-2.32.3
BMI without tail0.72.02.5-1.51.6-1.21.3
Body weight0.31.32.3-1.31.5-0.60.9
Weight adjusted by age0.30.40.7-0.90.80.40.3
Bone surface0.61.12.0-1.41.0-0.70.8
Bone volume0.81.42.2-1.51.3-0.91.0
Breakpoint value in progressive ratio session0.40.40.8-0.90.3-0.60.7
Number of licking bursts0.00.10.1-0.10.1-0.30.3
Context. condit. distance diff. score0.00.00.10.1-0.1-0.30.2
Locomotion velocity, session 16.16.66.72.6-2.62.5-2.6
Locomotion distance, session 11.31.71.91.3-1.21.4-1.3
Locomotion velocity, session 24.14.76.02.0-1.92.4-2.4
Locomotion distance, session 21.42.02.11.4-1.41.4-1.5
Locomotion velocity, session 36.16.97.22.6-2.72.5-2.7
Locomotion distance, session 35.15.56.02.3-2.52.2-2.4
Stereotopy head waving bouts, day 32.52.93.8-1.91.7-1.61.6
Stereotopy head waving duration, day 30.10.20.4-0.60.4-0.20.3
Locomotion velocity, session 70.50.61.10.9-1.00.4-0.5
Locomotion distance, session 72.93.64.22.0-2.01.5-1.9
Stereotopy head waving bouts, day 74.14.75.3-2.22.1-2.02.3
Stereotopy head waving duration, day 72.22.73.1-1.71.7-1.41.8
Locomotion velocity, session 80.10.10.20.4-0.40.2-0.3
Locomotion distance, session 81.92.83.21.7-1.81.5-1.7
Degree of sensitization distance0.60.60.9-0.60.7-0.90.8
Degree of sensitization stereotypy2.42.63.1-1.61.6-1.51.8
Conditioned locomotion0.50.50.70.5-0.70.8-0.8
Cocaine response after cond. corrected0.00.00.10.20.10.2-0.1
Cocaine response after cond. not corrected0.10.10.10.4-0.10.3-0.2
Cocaine response before conditioning0.50.61.10.8-1.00.5-0.7
Saline control response0.00.00.00.1-0.2-0.10.1
Bone: connectivity density0.10.10.2-0.1-0.30.4-0.3
Bone: cortical apparent density1.11.52.0-1.21.4-1.01.2
Bone: cortical area0.91.41.9-1.41.3-1.01.0
Bone: cortical porosity1.51.71.81.3-1.21.3-1.3
Bone: cortical porosity1.61.71.81.3-1.31.3-1.3
Bone: cortical thickness0.30.50.7-0.90.8-0.60.6
Bone: cortical thickness1.11.31.91.1-0.91.4-1.2
Bone: cortical tissue density0.91.31.7-1.11.3-0.91.1
Condit. Reinf. active minus inactive responses0.40.40.60.5-0.60.8-0.6
Condit. Reinf. active-inactive response ratio0.60.61.00.7-0.81.0-0.7
Condit. Reinf. active responses0.91.21.51.0-1.01.2-1.1
Condit. Reinf. inactive responses0.81.01.21.1-0.81.0-1.1
Incentive salience index mean0.00.10.10.2-0.20.3-0.2
Condit. Reinf. lever presses0.40.50.7-0.60.7-0.70.8
Condit. Reinf. active minus inactive responses1.31.71.9-1.31.2-1.41.3
Condit. Reinf. active-inactive response ratio0.40.40.5-0.50.7-0.60.7
Condit. Reinf. active responses1.72.43.0-1.61.2-1.71.6
Condit. Reinf. inactive responses0.30.40.6-0.70.3-0.80.5
Condit. Reinf. lever presses0.20.20.50.5-0.70.2-0.4
Condit. Reinf. lever reinforcers received0.71.01.4-1.00.6-1.21.0
Conditioned reinforcement - actives0.10.20.70.2-0.2-0.80.3
Conditioned reinforcement - inactives0.20.20.40.7-0.60.3-0.3
Conditioned locomotion0.10.10.30.3-0.4-0.50.1
Patch foraging indifference point 0 sec0.20.40.70.8-0.80.2-0.5
Patch foraging indifference point AUC0.20.20.5-0.50.5-0.20.7
Delay disc. indifference point, 0s delay0.10.10.2-0.10.40.20.0
Delay disc. indifference point, 16s delay0.10.10.2-0.40.3-0.10.5
Delay disc. indifference point, 2s delay6.06.77.2-2.52.7-2.62.6
Delay disc. indifference point, 24s delay0.10.10.2-0.20.5-0.00.5
Delay disc. indifference point, 4s delay0.30.30.4-0.40.5-0.50.6
Delay disc. indifference point, 8s delay0.10.20.20.5-0.30.4-0.4
Indifference point function ln k0.00.00.2-0.00.10.1-0.4
Indifference point function log k0.00.00.2-0.00.10.1-0.4
Patch foraging total patch changes 0 sec0.61.11.61.2-1.20.7-0.9
Patch foraging total patch changes 12 sec0.10.10.20.4-0.3-0.20.1
Patch foraging total patch changes 18 sec0.20.20.60.6-0.80.1-0.1
Patch foraging total patch changes 24 sec0.10.10.20.1-0.1-0.50.5
Patch foraging total patch changes 6 sec0.00.00.10.1-0.0-0.30.2
Patch foraging time to switch 0 sec0.10.20.5-0.20.4-0.70.4
Patch foraging water rate 0 sec0.00.00.00.1-0.10.1-0.1
Patch foraging water rate 12 sec0.51.11.70.9-1.30.9-1.2
Patch foraging water rate 18 sec0.00.00.10.2-0.1-0.40.0
Patch foraging water rate 24 sec0.50.71.5-0.70.6-1.20.7
Patch foraging water rate 6 sec0.20.30.40.6-0.60.5-0.4
Seeking ratio, delayed vs. immediate footshock0.10.10.3-0.0-0.60.2-0.2
Distance traveled before self-admin0.00.00.10.1-0.00.20.1
Distance traveled after self-admin1.31.63.01.7-1.50.6-0.8
Extensor digitorum longus weight7.328.535.3-5.75.9-4.55.1
Bone: elastic displacement4.45.15.92.3-2.42.0-2.3
Bone: elastic work3.14.14.72.0-1.82.2-2.1
Bone: endosteal estimation0.41.01.4-1.21.1-0.80.9
Bone: endosteal perimeter0.81.82.4-1.51.5-1.01.2
Epididymis fat weight3.010.111.43.0-3.13.4-3.2
Delta time in closed arm before/after self-admin0.30.30.4-0.60.2-0.70.5
Delta time in open arm before/after self-admin4.64.66.81.9-1.82.6-2.2
Diff in mean of infusions in LGA sessions0.50.71.3-1.11.0-0.30.6
Delay discount exponential model param0.30.30.50.5-0.70.3-0.6
Extinction: sum of active levers before priming1.41.52.6-1.61.4-0.81.0
Active lever presses in extinction session 60.00.00.0-0.1-0.2-0.10.1
Bone: final force0.40.71.1-1.01.0-0.40.6
Bone: final moment0.50.71.3-1.11.0-0.50.6
Food consumed during 24 hour testing period0.50.70.80.8-0.90.8-0.8
Glucose0.40.60.70.6-0.90.7-0.9
Heart weight0.10.10.30.1-0.30.5-0.2
Delay discount hyperbolic model param0.50.50.80.7-0.90.5-0.8
Intermittent access intake day 1-15 change0.20.50.80.9-0.90.4-0.6
Intermittent access intake escalation0.10.20.20.5-0.40.4-0.3
Intermittent access intake escalation 20.20.20.30.5-0.50.3-0.4
Intermitt. access day 1 inactive lever presses0.41.61.9-1.11.1-1.41.4
Intermitt. access day 15 inactive lever presses0.00.00.0-0.0-0.00.1-0.1
Intermitt. access escalation Index2.13.04.7-1.51.4-2.21.7
Intermittent access day 1 total infusions0.10.10.20.2-0.2-0.50.5
Intermittent access day 15 total infusions0.10.10.20.5-0.4-0.20.2
Intermittent access terminal intake (last 3 days)0.30.41.00.2-0.2-1.00.6
Intermittent access total infusions0.40.51.1-0.10.0-1.00.9
Intermittent access day 1 locomotion0.20.20.50.2-0.3-0.70.5
Intermittent access day 15 total locomotion0.81.52.01.3-1.41.2-1.0
Intermittent access total locomotion0.10.20.30.5-0.6-0.10.1
Intermittent access standard deviation0.71.52.01.2-1.21.4-0.9
Left kidney weight0.00.20.5-0.20.70.50.0
Right kidney weight0.10.41.2-0.61.10.40.2
Cocaine induced anxiety0.00.10.10.3-0.30.0-0.2
Post-drug Anxiety0.20.20.50.7-0.6-0.1-0.3
Baseline Anxiety0.00.00.10.0-0.00.3-0.2
Tail length0.51.93.01.7-1.21.3-1.3
Length with tail0.31.21.91.4-0.51.3-0.9
Length without tail0.00.10.1-0.00.20.4-0.1
Times rat made contact with spout0.50.60.70.7-0.80.8-0.8
Lifetime Intake0.30.40.80.0-0.1-0.90.8
Liver weight, left0.30.50.8-0.80.9-0.50.5
Liver weight, right0.10.10.3-0.20.30.5-0.2
Locomotor activity0.00.00.10.2-0.30.1-0.2
Locomotor testing distance0.20.40.70.7-0.80.4-0.6
Locomotor testing rearing0.30.50.80.7-0.50.9-0.7
Locomotion in novel chamber2.63.44.5-2.11.9-1.61.7
Locomotion in novel chamber post-restriction1.11.73.3-1.10.9-1.81.4
Fecal boli incidents, locomotor time 13.04.44.72.1-2.22.1-2.0
Change in fecal boli incidents, locomotor task0.90.91.4-1.00.7-1.20.8
Time >=10cm from walls, locomotor time 10.80.91.10.9-1.00.9-1.0
Bouts of movement, locomotor time 10.40.40.60.8-0.80.5-0.5
Total resting periods, locomotor time 11.31.52.01.2-1.41.0-1.1
Rest time, locomotor task time 10.81.01.31.1-1.10.8-0.9
Distance moved, locomotor task time 11.52.22.5-1.41.5-1.61.4
Vertical activity count, locomotor time 11.43.23.6-1.71.9-1.71.9
Time >=10cm from walls, locomotor time 20.20.30.50.7-0.6-0.0-0.4
Bouts of movement, locomotor time 22.03.24.0-1.71.8-2.01.7
Total resting periods, locomotor time 22.33.94.7-1.91.9-2.21.9
Rest time, locomotor task time 20.20.30.70.4-0.80.4-0.4
Distance moved, locomotor task time 20.10.10.2-0.10.5-0.30.1
Vertical activity count, locomotor time 20.30.40.5-0.50.7-0.60.6
Light reinforcement 10.00.10.20.1-0.2-0.40.3
Light reinforcement 20.20.20.30.6-0.40.6-0.4
Bone: marrow area0.40.91.3-1.11.0-0.70.8
Bone: maximum diameter0.61.21.4-1.21.0-1.11.1
Bone: maximum force1.01.82.4-1.51.5-1.11.1
Bone: maximum moment1.01.72.4-1.51.5-1.01.1
Mean time between licks in bursts0.51.21.71.1-1.30.7-1.2
Mean num. licks in bursts0.61.01.40.8-0.91.2-1.1
Cd content in liver0.30.30.50.6-0.70.4-0.5
Co content in liver0.20.30.4-0.60.6-0.30.5
Cu content in liver1.11.32.8-0.80.5-1.71.2
Fe content in liver0.00.00.10.1-0.1-0.30.0
K content in liver0.00.00.0-0.20.10.10.1
Mg content in liver0.10.10.30.4-0.50.2-0.3
Mn content in liver0.00.00.0-0.10.10.1-0.1
Na content in liver0.20.20.4-0.50.0-0.70.3
Rb content in liver0.10.10.30.1-0.4-0.50.2
Se content in liver0.80.91.71.3-0.90.6-0.9
Sr content in liver0.60.51.20.1-0.51.1-0.8
Zn content in liver1.11.32.01.2-1.40.8-1.0
Bone: minimum diameter1.12.02.8-1.71.6-1.11.3
Time in familiar zone, hab. session 10.80.71.20.7-0.61.1-0.9
Time in novel zone, hab. session 12.22.22.7-1.41.3-1.61.7
Total zone transitions, hab. session 10.40.50.8-0.70.5-0.90.7
Total locomotion distance, hab. session 10.50.70.80.8-0.90.8-0.8
Locomotion velocity, hab. session 10.50.80.90.8-0.90.8-1.0
Time in familiar zone, hab. session 20.10.10.1-0.1-0.10.3-0.3
Time in novel zone, hab. session 20.50.50.6-0.50.6-0.80.8
Total zone transitions, hab. session 20.30.30.40.6-0.60.5-0.6
Total locomotion distance, hab. session 20.70.91.30.8-0.81.1-1.1
Locomotion velocity, hab. session 21.01.41.91.0-1.01.4-1.3
Novel to familiar place preference ratio0.70.81.0-0.91.0-0.70.8
Novelty place preference0.40.50.6-0.70.8-0.60.6
Time in novel zone, NPP test0.60.70.8-0.90.9-0.70.8
Total zone transitions, NPP test0.91.31.51.2-1.21.1-1.0
Total locomotion distance, NPP test2.83.94.51.9-1.82.1-1.9
Locomotion velocity, NPP test3.24.55.42.1-2.02.3-2.1
Intraocular pressure0.40.61.21.0-1.1-0.4-0.3
Delta distance traveled before/after self-admin4.34.66.52.6-2.31.7-1.9
Delta ambulatory time before/after self-admin2.93.55.32.3-2.11.3-1.7
Parametrial fat weight1.02.43.81.9-2.00.9-1.2
Pavlov. Cond. lever latency2.12.63.91.4-1.32.0-1.7
Pavlov. Cond. magazine entry latency2.83.64.4-1.81.7-2.12.0
Pavlov. Cond. change in total contacts4.14.45.1-2.01.9-2.32.2
Pavlov. Cond. index score4.96.17.5-2.32.3-2.72.6
Pavlov. Cond. latency score4.86.17.7-2.32.2-2.82.6
Pavlov. Cond. lever contacts2.22.73.9-1.41.3-2.01.7
Pavlov. Cond. magazine entry number2.12.63.31.5-1.41.8-1.7
Pavlov. Cond. intertrial magazine entries1.92.32.51.6-1.51.5-1.5
Pavlov. Cond. lever-magazine prob. diff.4.85.97.4-2.32.2-2.72.5
Pavlov. Cond. response bias1.31.72.3-1.21.1-1.51.4
Pavlov. Cond. lever latency1.31.72.4-1.41.5-1.11.2
Pavlov. Cond. magazine entry latency3.44.14.62.0-1.92.2-2.0
Pavlov. Cond. change in total contacts0.61.01.2-1.00.8-1.11.1
Pavlov. Cond. index score1.82.42.71.6-1.61.5-1.5
Pavlov. Cond. latency score1.72.32.51.6-1.61.4-1.4
Pavlov. Cond. lever contacts2.12.93.51.7-1.91.5-1.6
Pavlov. Cond. magazine entry number1.01.21.2-1.11.1-1.11.1
Pavlov. Cond. intertrial magazine entries0.81.21.21.1-1.11.1-1.1
Pavlov. Cond. lever-magazine prob. diff.1.31.71.91.3-1.41.3-1.3
Pavlov. Cond. response bias1.72.32.91.5-1.71.4-1.4
Time in closed arm before self-admin1.01.32.1-0.91.5-1.11.0
Time in closed arm after self-admin4.24.55.8-1.91.9-2.42.2
Time in open arm before self-admin1.31.42.1-1.00.9-1.41.4
Time in open arm after self-admin1.41.62.71.1-0.91.6-1.3
Bone: periosteal estimation1.02.02.7-1.71.5-1.21.3
Bone: periosteal perimeter1.93.24.0-2.02.0-1.51.6
Bone: post-yield work0.60.91.2-1.10.8-1.00.8
Progressive ratio test 1 active lever presses0.50.61.41.2-1.0-0.1-0.1
Progressive ratio test 1 breakpoint0.70.81.71.3-1.2-0.0-0.2
Progressive ratio test 1 inactive lever presses0.60.91.4-0.50.8-1.11.2
Progressive ratio test 2 active lever presses0.50.61.4-0.20.1-1.21.0
Progressive ratio test 2 breakpoint0.70.91.8-0.40.3-1.31.2
Progressive ratio test 2 inactive lever presses0.10.10.20.3-0.2-0.40.4
Incentive Sensitization - Responses0.71.01.3-1.00.9-1.01.2
Incentive Sensitization - Breakpoint1.11.41.8-1.21.1-1.21.3
Sum of active levers in priming session hrs 5-60.30.30.5-0.70.4-0.30.6
Progressive ratio0.00.10.1-0.20.1-0.30.3
Food seeking constrained by brief footshock0.40.51.10.20.0-1.00.9
Seeking ratio, punishment vs. effort0.00.00.10.2-0.0-0.20.2
Retroperitoneal fat weight2.912.214.73.8-3.83.0-3.3
Reaction time number correct1.01.92.21.5-1.41.3-1.4
Reaction time mean minus median0.10.10.2-0.30.5-0.10.4
Reaction time mean minus median AUC0.10.40.5-0.50.7-0.40.7
Reaction time num false alarms0.60.81.01.0-1.00.9-0.8
Reaction time num false alarms AUC0.30.40.50.7-0.70.7-0.6
Reaction time trials correct on left1.01.92.21.5-1.41.3-1.4
Reaction time trials on left1.12.12.41.5-1.41.4-1.5
Reaction time mean0.30.50.9-0.71.0-0.40.7
Reaction time mean AUC0.40.61.1-0.71.0-0.40.7
Median of all reaction times0.30.40.8-0.60.9-0.30.5
Reaction time omissions0.71.12.61.0-0.41.6-0.8
Reaction time false alarm rate0.10.20.3-0.50.3-0.40.5
Reaction time premature initiation rate0.81.12.01.4-1.10.9-0.8
Reaction time premature initiations1.73.04.32.1-1.71.6-1.5
Std. dev. reaction times0.20.40.7-0.70.8-0.30.7
Reaction time trials completed1.12.12.41.5-1.41.4-1.5
Reaction time trials AUC0.81.61.91.4-1.21.2-1.3
Run reversals in cocaine runway, females0.10.10.30.4-0.10.5-0.4
Run reversals in cocaine runway, males1.01.02.1-1.21.4-0.20.8
Latency to leave start box in cocaine runway0.20.30.3-0.40.6-0.60.5
Latency to leave start box in cocaine runway, F0.20.20.3-0.30.6-0.30.5
Latency to leave start box in cocaine runway, M0.40.30.8-0.50.3-0.90.4
Std. dev. time between licks in bursts1.62.22.31.5-1.51.5-1.5
Total sessions with >9 infusions0.40.51.1-0.30.2-0.91.0
Short access day 1 total inactive lever presses0.10.10.10.3-0.2-0.30.3
Short access day 10 total inactive lever presses0.20.50.9-0.50.5-1.00.7
Short access day 1 total infusions0.10.10.20.2-0.2-0.40.4
Short access day 10 total infusions0.40.51.0-0.30.1-1.00.9
Short access total infusions0.20.20.50.1-0.3-0.70.6
Short access day 1 locomotion0.10.10.3-0.20.3-0.20.6
Short access day 10 total locomotion0.10.20.3-0.50.4-0.40.6
Short access total locomotion0.30.30.7-0.30.3-0.70.8
One hour access (0.3 mA shock)2.02.33.0-1.31.3-1.61.7
Compulsive drug intake1.61.92.8-1.21.1-1.71.6
One hour access (shock baseline)0.40.60.8-0.60.6-0.90.8
Social response proportion1.61.82.21.5-1.31.4-1.2
Social responses0.50.71.00.8-0.51.0-0.8
Social time1.41.93.81.0-0.92.0-1.4
Soleus weight0.00.10.30.00.10.5-0.2
Bone: stiffness2.94.75.7-2.32.4-1.82.1
Tibialis anterior weight9.933.440.7-6.06.4-5.15.6
Time to tail flick, vehicle, before self-admin0.70.71.0-0.70.8-1.00.8
Time to tail flick, vehicle, after self-admin0.10.20.4-0.60.60.30.0
Time to tail flick, test, before self-admin0.10.10.4-0.20.60.30.2
Time to tail flick, test, after self-admin1.11.12.2-1.51.3-0.40.7
Delta time to tail flick, vehicle, before/after SA0.30.30.70.2-0.40.8-0.6
Delta time to tail flick, test, before/after SA0.30.30.7-0.80.5-0.40.3
Tibia length0.10.20.4-0.40.4-0.70.3
Ambulatory time before self-admin0.00.00.10.1-0.20.3-0.0
Ambulatory time after self-admin1.21.42.41.5-1.50.6-0.8
Bone: tissue strength1.91.92.1-1.41.3-1.41.3
Total heroin consumption0.20.20.3-0.40.3-0.60.5
Bone: trabecular number0.10.20.40.1-0.20.6-0.4
Bone: trabecular spacing0.81.02.2-0.60.5-1.51.1
Bone: trabecular thickness0.10.10.2-0.50.4-0.00.2
Bone: trabecular tissue density1.82.73.0-1.51.6-1.71.7
Water consumed over 24 hours0.40.50.60.6-0.80.7-0.8
Number of responses in last shaping day2.12.35.21.2-0.82.3-1.4