Hub : Genes

Pacs1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Pacs1 0.07 0.06 6.2e-03 0.02 0.03 0.01 0.02 3.1e-02 6.3e-03 9.4e-02 2.4e-02
2 IL gene expression Pacs1 0.22 0.12 1.5e-04 0.06 0.12 0.07 0.07 1.3e-02 9.7e-04 1.1e-02 7.2e-03
3 PL gene expression Pacs1 0.13 0.08 5.5e-14 0.12 0.13 0.12 0.12 7.0e-13 9.0e-14 3.3e-13 9.2e-13
4 NAcc gene expression Pacs1 0.16 0.1 4.7e-07 0.04 0.04 0.05 0.04 3.8e-06 6.8e-07 1.7e-07 6.3e-07
5 IC gene expression Pacs1 0.26 0.14 6.4e-09 0.14 0.17 0.13 0.14 1.9e-06 1.6e-07 4.2e-06 2.1e-06
6 OFC gene expression Pacs1 0.34 0.18 5.4e-05 0.14 0.11 0.07 0.05 3.7e-04 1.5e-03 8.8e-03 2.5e-02
7 Adipose gene expression Pacs1 0.2 0.08 2.6e-15 0.11 0.11 0.1 0.12 7.0e-12 1.5e-12 1.5e-11 9.2e-13
8 Brain gene expression Pacs1 0.12 0.06 1.9e-13 0.15 0.15 0.15 0.14 3.5e-14 1.7e-13 1.2e-13 2.2e-13
9 Adipose mRNA stability Pacs1 0.16 0.1 3.3e-04 0.02 0.02 0.01 0.01 2.8e-03 3.5e-03 6.0e-02 6.9e-03
10 IL mRNA stability Pacs1 0.23 0.13 2.7e-03 0.04 0.05 0.01 0.03 3.5e-02 2.1e-02 1.6e-01 6.4e-02
11 NAcc mRNA stability Pacs1 0.09 0.08 5.9e-04 0.02 0.01 0.02 0.01 8.0e-04 1.8e-03 5.5e-04 3.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.61.05.8-0.1-0.2-0.50.1-0.71.00.91.00.8-2.41.0
Area under the delay curve0.81.21.8-0.8-0.8-0.91.2-1.01.01.11.21.2-1.11.4
BMI with tail0.82.717.60.50.3-0.3-0.3-0.81.21.21.10.9-4.22.4
BMI without tail0.31.46.50.30.3-0.10.4-0.41.11.11.00.7-2.62.2
Body weight0.73.06.72.62.52.1-1.81.7-1.0-1.1-1.0-1.4-1.90.4
Weight adjusted by age0.82.23.31.71.71.6-1.81.6-1.4-1.5-1.5-1.50.4-1.1
Bone surface1.22.35.72.01.81.4-2.41.1-0.7-1.0-0.6-1.1-2.3-0.8
Bone volume0.40.84.70.80.70.3-1.50.10.1-0.10.2-0.4-2.2-0.4
Breakpoint value in progressive ratio session1.32.44.22.01.81.6-2.01.5-1.4-1.4-1.6-1.6-0.5-1.1
Number of licking bursts0.10.30.60.70.60.5-0.80.5-0.7-0.6-0.7-0.3-0.2-0.5
Context. condit. distance diff. score1.72.12.9-1.6-1.6-1.51.7-1.41.51.51.51.3-0.01.2
Locomotion velocity, session 10.10.10.40.10.20.30.30.3-0.1-0.1-0.2-0.60.60.2
Locomotion distance, session 10.40.62.4-0.1-0.1-0.30.5-0.40.80.60.70.3-1.61.3
Locomotion velocity, session 20.70.91.81.31.31.1-1.00.9-0.7-0.6-0.7-1.0-0.80.2
Locomotion distance, session 20.20.31.50.30.30.10.1-0.00.50.30.4-0.2-1.21.1
Locomotion velocity, session 30.60.71.3-0.7-0.8-0.80.9-0.90.70.80.70.7-0.91.2
Locomotion distance, session 30.00.00.0-0.1-0.1-0.10.2-0.1-0.1-0.10.0-0.1-0.10.1
Stereotopy head waving bouts, day 31.82.13.1-1.4-1.4-1.41.7-1.51.41.41.61.5-0.91.8
Stereotopy head waving duration, day 31.51.82.7-1.5-1.4-1.41.2-1.51.31.31.51.6-0.81.1
Locomotion velocity, session 71.61.82.9-1.0-1.1-1.31.0-1.31.51.51.41.3-1.41.7
Locomotion distance, session 70.50.72.4-0.4-0.4-0.51.0-0.50.80.80.90.8-0.71.6
Stereotopy head waving bouts, day 70.30.31.0-0.4-0.5-0.6-0.2-0.70.60.50.60.3-1.0-0.0
Stereotopy head waving duration, day 70.20.21.70.40.20.1-0.8-0.1-0.1-0.1-0.0-0.1-1.3-0.2
Locomotion velocity, session 80.70.91.51.11.21.2-0.41.2-0.9-1.1-0.7-1.00.4-0.3
Locomotion distance, session 80.71.01.6-0.9-0.9-1.00.8-1.01.21.11.00.7-0.71.1
Degree of sensitization distance0.60.61.6-0.4-0.4-0.50.7-0.51.00.90.90.9-0.91.3
Degree of sensitization stereotypy0.30.31.20.60.40.2-1.10.2-0.2-0.3-0.3-0.6-0.7-0.6
Conditioned locomotion1.01.22.21.41.51.4-0.91.4-0.9-0.9-0.9-1.20.4-0.4
Cocaine response after cond. corrected0.81.22.9-1.2-1.1-1.01.7-0.91.11.11.00.80.31.2
Cocaine response after cond. not corrected0.60.81.9-1.0-1.0-0.91.4-0.80.90.90.70.70.10.9
Cocaine response before conditioning0.70.92.20.90.80.7-1.50.7-1.0-1.0-1.1-0.7-0.3-1.1
Saline control response1.62.24.32.02.11.9-1.31.7-1.0-1.4-1.2-1.6-0.5-0.5
Bone: connectivity density0.50.85.60.90.90.6-0.80.20.30.10.40.2-2.40.5
Bone: cortical apparent density0.20.40.60.60.60.6-0.30.7-0.8-0.8-0.7-0.60.7-0.4
Bone: cortical area0.91.42.21.31.21.2-1.41.2-1.2-1.2-1.2-1.50.3-1.0
Bone: cortical porosity0.10.20.8-0.1-0.1-0.20.2-0.30.30.30.10.5-0.90.5
Bone: cortical porosity0.10.10.70.20.30.2-0.10.00.10.0-0.20.2-0.80.4
Bone: cortical thickness4.27.09.03.03.03.0-1.93.0-2.9-2.7-3.0-2.91.6-1.4
Bone: cortical thickness1.21.52.71.21.41.4-0.31.5-1.6-1.4-1.3-1.11.1-0.2
Bone: cortical tissue density0.40.60.80.80.80.8-0.40.8-0.9-0.9-0.8-0.80.7-0.5
Condit. Reinf. active minus inactive responses0.10.10.40.30.20.10.00.00.50.30.0-0.6-0.70.6
Condit. Reinf. active-inactive response ratio0.10.10.30.10.0-0.00.1-0.00.50.40.0-0.4-0.40.4
Condit. Reinf. active responses0.10.10.40.10.0-0.1-0.2-0.10.60.50.2-0.5-0.60.5
Condit. Reinf. inactive responses0.10.20.3-0.3-0.4-0.4-0.2-0.40.60.50.60.3-0.50.3
Incentive salience index mean0.20.20.90.30.2-0.0-0.0-0.10.60.50.3-0.5-1.00.9
Condit. Reinf. lever presses0.20.20.90.70.50.4-0.80.30.0-0.0-0.1-0.9-0.50.1
Condit. Reinf. active minus inactive responses0.20.20.6-0.3-0.5-0.5-0.5-0.60.50.30.40.5-0.8-0.6
Condit. Reinf. active-inactive response ratio0.40.61.0-0.8-1.0-1.0-0.4-1.00.70.70.70.6-0.5-0.6
Condit. Reinf. active responses0.20.32.0-0.1-0.2-0.3-0.4-0.50.50.30.30.9-1.4-0.1
Condit. Reinf. inactive responses0.20.31.90.20.20.10.3-0.10.20.20.10.9-1.40.8
Condit. Reinf. lever presses1.01.43.61.51.31.1-1.91.0-1.0-1.0-1.0-0.6-0.9-1.1
Condit. Reinf. lever reinforcers received0.20.31.70.20.10.0-0.7-0.20.1-0.00.00.6-1.3-0.4
Conditioned reinforcement - actives0.21.03.90.40.40.4-1.80.5-0.8-0.9-0.8-0.60.6-2.0
Conditioned reinforcement - inactives0.41.22.3-1.5-1.5-1.4-0.5-1.20.80.71.00.90.4-1.3
Conditioned locomotion2.33.47.2-2.7-2.6-2.41.2-2.11.61.51.71.71.0-0.3
Patch foraging indifference point 0 sec0.10.20.4-0.4-0.4-0.40.2-0.50.40.40.40.7-0.50.2
Patch foraging indifference point AUC1.33.14.72.01.91.9-2.21.8-1.6-1.9-1.6-1.90.3-1.7
Delay disc. indifference point, 0s delay2.62.94.6-1.5-1.4-1.52.1-1.51.71.81.81.8-1.12.1
Delay disc. indifference point, 16s delay0.71.01.4-1.1-1.1-1.20.6-1.21.01.01.21.1-0.80.4
Delay disc. indifference point, 2s delay0.40.40.6-0.7-0.7-0.70.6-0.80.60.70.50.7-0.60.5
Delay disc. indifference point, 24s delay0.10.10.6-0.2-0.1-0.00.80.00.10.20.20.10.40.6
Delay disc. indifference point, 4s delay1.21.32.4-0.9-0.8-0.91.5-0.91.11.11.21.3-0.81.5
Delay disc. indifference point, 8s delay0.50.91.9-0.7-0.6-0.61.4-0.70.80.91.21.0-0.71.4
Indifference point function ln k2.47.413.5-3.3-3.2-3.03.7-2.72.42.82.22.20.62.5
Indifference point function log k2.47.413.5-3.3-3.2-3.03.7-2.72.42.82.22.20.62.5
Patch foraging total patch changes 0 sec0.00.00.1-0.1-0.0-0.00.2-0.10.00.00.00.20.10.1
Patch foraging total patch changes 12 sec1.82.44.82.22.11.9-1.71.7-1.3-1.5-1.3-1.3-0.8-0.6
Patch foraging total patch changes 18 sec0.10.30.60.70.60.5-0.80.4-0.3-0.4-0.4-0.2-0.7-0.3
Patch foraging total patch changes 24 sec0.72.33.31.81.81.8-1.51.7-1.4-1.6-1.5-1.40.4-1.2
Patch foraging total patch changes 6 sec0.30.51.21.11.11.0-0.20.8-0.5-0.6-0.5-0.5-0.70.3
Patch foraging time to switch 0 sec0.20.85.40.70.60.2-1.3-0.00.20.30.20.2-2.30.4
Patch foraging water rate 0 sec0.41.36.2-1.5-1.4-1.01.5-0.60.50.40.40.32.5-0.3
Patch foraging water rate 12 sec1.04.211.1-2.8-2.5-2.03.3-1.51.41.31.31.52.60.9
Patch foraging water rate 18 sec0.81.96.0-1.7-1.5-1.32.5-1.11.01.00.91.11.21.2
Patch foraging water rate 24 sec1.21.74.3-1.8-1.6-1.22.0-0.90.80.90.90.52.10.3
Patch foraging water rate 6 sec1.21.86.7-1.6-1.4-1.02.6-0.70.70.60.70.42.20.8
Seeking ratio, delayed vs. immediate footshock0.50.81.3-0.7-0.7-0.80.3-0.91.00.91.01.1-1.20.8
Distance traveled before self-admin0.10.20.90.40.30.2-1.00.0-0.1-0.2-0.2-0.0-0.9-0.4
Distance traveled after self-admin0.20.31.10.50.40.4-1.00.3-0.4-0.5-0.2-0.3-0.2-0.9
Extensor digitorum longus weight3.915.428.25.35.14.7-4.04.4-3.7-3.5-3.6-4.1-0.4-1.2
Bone: elastic displacement0.40.53.7-0.10.10.31.00.6-0.3-0.4-0.4-0.61.90.0
Bone: elastic work1.31.72.81.51.61.7-0.11.7-1.2-1.2-1.3-1.61.20.0
Bone: endosteal estimation1.74.16.2-2.0-2.1-2.21.2-2.32.52.32.51.7-1.71.4
Bone: endosteal perimeter1.94.66.4-2.1-2.3-2.50.9-2.52.52.42.51.9-2.00.9
Epididymis fat weight1.15.710.8-3.2-3.3-3.11.7-2.82.42.42.22.20.40.3
Delta time in closed arm before/after self-admin0.30.31.20.30.50.50.90.50.00.0-0.1-0.20.21.1
Delta time in open arm before/after self-admin0.60.72.30.60.50.5-1.50.5-0.9-0.9-0.6-0.70.1-1.4
Diff in mean of infusions in LGA sessions0.50.91.21.11.11.0-1.01.0-0.8-0.9-1.0-1.10.3-0.8
Delay discount exponential model param0.60.81.30.70.60.7-1.00.7-0.8-0.9-1.0-1.00.9-1.1
Extinction: sum of active levers before priming0.60.92.01.31.20.9-1.40.7-0.5-0.6-0.7-0.7-1.2-0.2
Active lever presses in extinction session 63.13.25.62.01.81.7-2.41.7-1.7-1.7-1.9-1.80.1-1.7
Bone: final force1.11.83.21.81.71.5-1.81.4-1.1-1.2-0.8-1.4-0.4-0.8
Bone: final moment1.01.62.81.71.61.4-1.61.3-1.0-1.1-0.8-1.3-0.4-0.7
Food consumed during 24 hour testing period0.40.92.50.60.50.6-1.10.7-1.0-1.0-0.9-0.90.9-1.6
Glucose4.36.88.1-2.7-2.8-2.82.4-2.82.82.82.82.6-1.82.3
Heart weight4.57.211.3-2.3-2.2-2.43.2-2.52.92.72.82.8-2.13.4
Delay discount hyperbolic model param0.60.81.30.70.70.7-1.00.8-0.9-0.9-1.0-1.11.0-1.1
Intermittent access intake day 1-15 change0.10.41.4-0.8-0.8-0.6-0.6-0.50.30.20.40.10.9-1.2
Intermittent access intake escalation0.10.42.1-0.5-0.6-0.4-0.9-0.30.1-0.00.1-0.31.0-1.5
Intermittent access intake escalation 20.20.41.7-0.6-0.6-0.5-0.7-0.30.10.00.1-0.31.0-1.3
Intermitt. access day 1 inactive lever presses0.00.00.2-0.2-0.2-0.2-0.2-0.20.10.10.1-0.10.2-0.4
Intermitt. access day 15 inactive lever presses0.21.01.8-1.2-1.3-1.3-0.3-1.21.00.91.01.0-0.3-0.5
Intermitt. access escalation Index1.54.56.7-2.4-2.3-2.22.6-2.12.22.22.22.2-0.41.9
Intermittent access day 1 total infusions2.26.48.8-2.6-2.6-2.71.5-2.82.82.82.93.0-2.11.6
Intermittent access day 15 total infusions1.43.56.2-2.4-2.5-2.40.5-2.22.01.92.11.9-0.3-0.3
Intermittent access terminal intake (last 3 days)2.13.76.0-2.4-2.5-2.40.5-2.32.12.02.22.1-0.8-0.1
Intermittent access total infusions3.54.15.6-2.3-2.3-2.40.9-2.32.32.22.32.3-1.30.6
Intermittent access day 1 locomotion2.13.95.6-2.1-2.1-2.21.2-2.22.12.12.22.4-1.61.2
Intermittent access day 15 total locomotion0.93.35.6-2.3-2.4-2.3-0.0-2.21.91.82.01.9-0.7-0.5
Intermittent access total locomotion5.66.710.2-3.1-3.2-3.20.7-3.12.82.82.92.8-1.40.3
Intermittent access standard deviation0.10.40.9-1.0-0.9-0.80.3-0.60.60.50.60.60.7-0.5
Left kidney weight0.42.94.5-2.1-2.1-2.11.0-2.02.12.01.91.2-0.10.9
Right kidney weight0.10.51.2-1.1-1.1-1.00.5-0.80.50.60.50.30.8-0.0
Cocaine induced anxiety0.10.10.90.30.20.2-0.90.1-0.3-0.3-0.2-0.1-0.1-0.7
Post-drug Anxiety0.80.91.91.00.90.9-1.40.8-1.1-1.1-0.8-0.7-0.0-1.1
Baseline Anxiety0.20.40.70.60.70.70.20.7-0.8-0.8-0.6-0.60.4-0.0
Tail length0.42.13.51.61.71.8-0.71.9-1.3-1.4-1.1-1.61.4-0.6
Length with tail1.56.710.43.23.23.2-1.83.1-2.5-2.6-2.4-2.91.2-1.2
Length without tail1.16.08.62.92.92.9-1.52.8-2.8-2.6-2.6-2.61.0-1.1
Times rat made contact with spout0.10.10.40.40.40.3-0.10.30.10.00.2-0.2-0.60.3
Lifetime Intake2.83.54.7-2.0-2.0-2.11.1-2.02.12.12.12.2-1.30.9
Liver weight, left0.40.71.5-1.0-0.9-0.71.2-0.61.00.80.60.30.90.7
Liver weight, right1.42.55.7-1.9-1.7-1.52.4-1.41.51.61.21.30.51.6
Locomotor activity0.60.93.6-1.2-0.9-0.71.9-0.40.40.50.20.61.50.7
Locomotor testing distance0.61.56.0-1.4-1.1-0.82.5-0.60.70.70.50.81.61.0
Locomotor testing rearing0.62.36.5-1.9-1.6-1.32.6-1.21.51.31.31.50.51.2
Locomotion in novel chamber2.53.36.3-2.5-2.5-2.31.3-2.11.71.81.81.80.30.2
Locomotion in novel chamber post-restriction0.72.03.7-1.9-1.9-1.81.1-1.71.41.41.31.40.10.3
Fecal boli incidents, locomotor time 10.20.52.50.30.20.2-1.50.2-0.4-0.5-0.7-0.30.2-1.6
Change in fecal boli incidents, locomotor task0.40.51.7-0.4-0.3-0.41.1-0.40.40.60.70.6-0.61.3
Time >=10cm from walls, locomotor time 11.61.92.8-1.3-1.5-1.60.2-1.71.51.41.51.6-1.60.6
Bouts of movement, locomotor time 11.41.83.21.51.41.3-1.81.3-1.4-1.5-1.1-1.30.2-1.6
Total resting periods, locomotor time 11.01.22.51.21.11.0-1.60.9-1.0-1.2-0.9-0.9-0.0-1.4
Rest time, locomotor task time 10.30.51.1-1.0-1.0-0.90.5-0.70.50.50.40.30.7-0.4
Distance moved, locomotor task time 10.20.61.8-0.2-0.2-0.40.7-0.50.70.70.70.6-1.31.3
Vertical activity count, locomotor time 10.10.50.9-0.9-0.9-0.80.7-0.70.70.80.70.80.00.6
Time >=10cm from walls, locomotor time 20.00.00.20.1-0.0-0.1-0.5-0.1-0.1-0.1-0.1-0.3-0.2-0.3
Bouts of movement, locomotor time 20.10.30.70.70.70.6-0.90.5-0.7-0.6-0.3-0.3-0.4-0.5
Total resting periods, locomotor time 20.00.10.30.30.30.2-0.60.2-0.4-0.20.1-0.0-0.5-0.3
Rest time, locomotor task time 21.01.82.9-1.7-1.7-1.61.4-1.41.21.41.31.10.20.7
Distance moved, locomotor task time 20.81.11.81.31.31.2-0.71.2-1.1-1.1-1.1-1.30.1-0.3
Vertical activity count, locomotor time 20.51.12.40.70.81.0-0.41.1-1.2-1.1-1.2-1.21.5-0.7
Light reinforcement 10.00.00.1-0.3-0.2-0.20.4-0.10.0-0.10.00.20.30.1
Light reinforcement 20.10.30.7-0.7-0.8-0.7-0.4-0.60.0-0.00.20.20.4-0.9
Bone: marrow area1.94.66.8-2.1-2.2-2.31.4-2.42.62.42.61.9-1.81.5
Bone: maximum diameter0.30.51.90.60.40.4-1.40.4-0.5-0.7-0.6-0.70.1-1.3
Bone: maximum force0.81.63.71.81.61.3-1.91.0-0.7-0.8-0.6-1.3-1.6-0.4
Bone: maximum moment0.71.43.01.71.51.2-1.70.9-0.6-0.7-0.6-1.2-1.5-0.3
Mean time between licks in bursts0.10.30.50.50.60.70.50.6-0.7-0.6-0.6-0.10.30.4
Mean num. licks in bursts0.20.61.1-0.7-0.6-0.60.8-0.61.00.91.10.4-0.20.8
Cd content in liver0.70.71.3-1.1-1.1-1.1-0.4-1.00.70.50.81.1-0.1-0.8
Co content in liver0.40.53.6-0.6-0.4-0.11.20.1-0.1-0.1-0.10.01.90.2
Cu content in liver0.20.20.5-0.3-0.3-0.40.3-0.50.30.50.30.4-0.70.7
Fe content in liver0.30.40.60.60.70.8-0.20.8-0.6-0.6-0.6-0.80.6-0.4
K content in liver0.20.20.70.30.30.10.30.00.40.30.20.2-0.80.9
Mg content in liver1.01.11.9-0.9-0.9-0.91.4-0.91.11.10.91.1-0.71.3
Mn content in liver2.52.84.62.12.01.8-2.01.7-1.5-1.7-1.6-1.5-0.2-1.3
Na content in liver1.21.32.41.11.01.1-0.71.1-1.3-1.2-1.4-1.51.0-0.9
Rb content in liver2.32.74.2-1.8-1.7-1.62.1-1.61.71.71.81.7-0.61.5
Se content in liver0.10.10.3-0.3-0.3-0.3-0.3-0.30.30.20.30.3-0.3-0.5
Sr content in liver3.32.93.41.81.81.8-1.81.8-1.7-1.8-1.8-1.80.8-1.4
Zn content in liver0.10.10.20.30.30.3-0.00.20.1-0.0-0.20.1-0.30.5
Bone: minimum diameter2.44.66.5-1.9-2.1-2.31.3-2.42.62.42.51.7-2.31.8
Time in familiar zone, hab. session 10.50.50.8-0.6-0.7-0.80.6-0.80.80.90.50.7-0.70.7
Time in novel zone, hab. session 10.10.20.9-0.10.00.20.60.2-0.5-0.5-0.0-0.10.9-0.1
Total zone transitions, hab. session 10.30.41.00.80.70.6-0.80.5-0.3-0.3-0.4-1.0-0.60.1
Total locomotion distance, hab. session 10.60.81.2-0.9-1.0-1.00.6-1.01.11.10.90.3-0.61.0
Locomotion velocity, hab. session 10.20.30.7-0.4-0.5-0.50.2-0.60.80.80.60.0-0.60.7
Time in familiar zone, hab. session 20.20.20.50.20.40.50.60.5-0.4-0.2-0.6-0.30.70.3
Time in novel zone, hab. session 20.20.31.0-0.3-0.3-0.4-0.1-0.50.50.30.80.5-1.00.2
Total zone transitions, hab. session 20.91.17.40.0-0.1-0.40.1-0.70.70.71.00.8-2.71.4
Total locomotion distance, hab. session 21.52.03.7-1.0-1.1-1.31.1-1.41.41.51.51.1-1.91.9
Locomotion velocity, hab. session 21.62.13.6-1.1-1.2-1.41.0-1.51.51.61.61.2-1.91.7
Novel to familiar place preference ratio0.50.62.70.90.70.5-1.60.4-0.4-0.6-0.5-0.4-0.7-1.1
Novelty place preference0.20.31.50.50.30.2-1.20.1-0.1-0.3-0.20.0-0.7-0.9
Time in novel zone, NPP test0.20.20.90.30.20.1-1.00.00.0-0.2-0.10.2-0.7-0.7
Total zone transitions, NPP test0.40.61.81.11.00.8-1.20.6-0.3-0.4-0.3-0.5-1.30.2
Total locomotion distance, NPP test0.30.51.2-0.3-0.4-0.50.4-0.60.90.80.80.2-0.91.1
Locomotion velocity, NPP test0.20.30.8-0.2-0.3-0.40.1-0.50.70.70.70.1-0.90.9
Intraocular pressure0.40.63.6-0.4-0.4-0.2-1.0-0.0-0.0-0.4-0.2-0.21.3-1.9
Delta distance traveled before/after self-admin0.10.10.50.00.10.20.30.3-0.2-0.30.0-0.20.7-0.1
Delta ambulatory time before/after self-admin0.10.10.50.20.30.40.10.4-0.3-0.4-0.1-0.30.7-0.2
Parametrial fat weight2.86.610.2-3.2-3.2-3.12.1-3.02.62.62.82.5-0.51.4
Pavlov. Cond. lever latency0.10.10.2-0.3-0.3-0.20.2-0.1-0.00.0-0.00.50.5-0.4
Pavlov. Cond. magazine entry latency0.20.31.9-0.1-0.2-0.4-0.2-0.60.40.60.50.0-1.40.5
Pavlov. Cond. change in total contacts0.10.20.60.2-0.1-0.2-0.7-0.3-0.00.2-0.2-0.6-0.8-0.1
Pavlov. Cond. index score0.10.10.60.40.30.2-0.50.1-0.4-0.3-0.3-0.8-0.3-0.1
Pavlov. Cond. latency score0.00.10.20.10.0-0.1-0.1-0.1-0.10.00.1-0.5-0.50.3
Pavlov. Cond. lever contacts0.10.10.50.0-0.0-0.10.2-0.20.20.20.2-0.3-0.50.7
Pavlov. Cond. magazine entry number0.40.51.2-0.7-0.5-0.41.0-0.40.80.60.71.10.00.7
Pavlov. Cond. intertrial magazine entries0.10.10.5-0.2-0.2-0.0-0.20.10.0-0.10.0-0.20.7-0.6
Pavlov. Cond. lever-magazine prob. diff.0.10.20.70.50.30.2-0.60.1-0.3-0.2-0.3-0.8-0.5-0.1
Pavlov. Cond. response bias0.20.31.00.60.40.4-0.80.3-0.6-0.4-0.6-1.0-0.0-0.4
Pavlov. Cond. lever latency0.71.02.3-1.0-0.9-0.91.5-0.91.01.01.00.9-0.11.2
Pavlov. Cond. magazine entry latency1.52.13.82.01.81.5-1.91.3-1.3-1.3-1.2-1.2-1.4-0.5
Pavlov. Cond. change in total contacts0.61.45.11.41.10.9-2.30.7-0.9-0.9-1.0-0.8-1.1-1.4
Pavlov. Cond. index score1.11.74.21.71.51.3-2.11.1-1.1-1.2-1.1-1.1-0.9-1.0
Pavlov. Cond. latency score1.01.64.11.61.41.2-2.01.0-1.1-1.1-1.1-1.1-0.8-1.0
Pavlov. Cond. lever contacts0.60.92.21.00.90.8-1.50.8-1.0-0.9-1.0-0.7-0.0-1.2
Pavlov. Cond. magazine entry number3.24.17.4-2.7-2.5-2.22.7-1.91.81.91.81.81.31.2
Pavlov. Cond. intertrial magazine entries0.30.61.2-1.1-1.1-1.00.5-0.90.70.70.60.80.4-0.1
Pavlov. Cond. lever-magazine prob. diff.1.32.14.81.81.71.4-2.21.2-1.2-1.3-1.2-1.2-1.0-1.1
Pavlov. Cond. response bias1.11.53.11.51.41.2-1.81.0-1.2-1.2-1.2-0.9-0.8-0.9
Time in closed arm before self-admin0.30.40.8-0.7-0.8-0.9-0.2-0.90.50.40.70.7-0.7-0.3
Time in closed arm after self-admin0.20.20.4-0.5-0.4-0.40.5-0.40.60.50.60.4-0.10.6
Time in open arm before self-admin0.81.05.0-0.5-0.2-0.12.2-0.10.80.90.20.30.52.0
Time in open arm after self-admin0.10.10.20.30.30.40.50.4-0.4-0.3-0.4-0.30.30.3
Bone: periosteal estimation0.10.20.6-0.3-0.4-0.5-0.3-0.60.70.50.6-0.0-0.70.0
Bone: periosteal perimeter0.10.21.00.1-0.1-0.3-0.4-0.40.40.30.40.0-1.0-0.1
Bone: post-yield work2.34.017.4-0.8-1.2-1.7-0.2-2.12.12.02.01.6-4.21.6
Progressive ratio test 1 active lever presses0.10.20.4-0.4-0.4-0.4-0.1-0.40.60.60.40.6-0.4-0.2
Progressive ratio test 1 breakpoint0.10.10.3-0.3-0.3-0.4-0.2-0.30.50.50.30.5-0.3-0.3
Progressive ratio test 1 inactive lever presses0.00.10.2-0.2-0.2-0.2-0.4-0.20.10.10.20.3-0.1-0.5
Progressive ratio test 2 active lever presses1.01.42.3-1.5-1.5-1.5-0.0-1.41.31.21.21.4-0.4-0.5
Progressive ratio test 2 breakpoint1.01.32.1-1.4-1.4-1.4-0.1-1.31.21.11.11.3-0.3-0.6
Progressive ratio test 2 inactive lever presses1.85.69.7-3.1-3.1-3.00.9-2.82.32.22.62.7-0.4-0.1
Incentive Sensitization - Responses0.10.30.9-0.3-0.3-0.5-0.6-0.50.60.50.40.6-0.9-0.2
Incentive Sensitization - Breakpoint0.20.30.7-0.4-0.5-0.6-0.4-0.60.70.60.50.7-0.9-0.1
Sum of active levers in priming session hrs 5-67.67.214.02.22.12.2-3.72.3-2.5-2.7-2.8-2.71.9-3.7
Progressive ratio0.41.26.2-0.1-0.2-0.5-0.0-0.81.00.91.11.1-2.51.3
Food seeking constrained by brief footshock0.10.10.20.40.40.4-0.10.4-0.2-0.2-0.2-0.50.10.1
Seeking ratio, punishment vs. effort0.20.53.8-0.4-0.30.01.00.2-0.3-0.2-0.3-0.51.9-0.1
Retroperitoneal fat weight5.825.841.2-6.4-6.3-5.85.5-5.55.05.05.04.90.33.0
Reaction time number correct0.30.91.70.90.91.0-0.51.0-1.1-0.9-1.3-1.11.0-0.7
Reaction time mean minus median0.53.37.52.11.91.7-2.71.6-1.7-1.7-1.7-1.7-0.5-1.6
Reaction time mean minus median AUC0.42.74.41.81.71.6-2.11.6-1.7-1.7-1.6-1.80.3-1.5
Reaction time num false alarms0.30.52.6-0.3-0.1-0.01.60.10.20.30.2-0.20.91.3
Reaction time num false alarms AUC0.20.41.50.30.40.51.20.5-0.3-0.1-0.2-0.60.71.2
Reaction time trials correct on left0.30.91.70.90.91.0-0.51.0-1.1-0.9-1.3-1.11.0-0.7
Reaction time trials on left0.41.22.01.01.11.1-0.61.2-1.2-1.0-1.4-1.31.1-0.8
Reaction time mean0.10.21.10.20.10.1-1.10.1-0.4-0.4-0.3-0.3-0.2-0.9
Reaction time mean AUC0.10.21.00.1-0.0-0.1-1.0-0.1-0.3-0.3-0.2-0.1-0.4-0.8
Median of all reaction times0.10.20.3-0.5-0.5-0.5-0.4-0.50.20.20.30.4-0.3-0.4
Reaction time omissions1.22.03.01.71.61.5-1.51.4-1.6-1.5-1.5-1.6-0.1-0.8
Reaction time false alarm rate0.40.52.2-0.4-0.3-0.21.5-0.20.40.50.60.10.31.5
Reaction time premature initiation rate1.32.03.61.71.91.8-0.01.7-1.3-1.6-1.6-1.30.30.3
Reaction time premature initiations1.54.57.02.52.62.6-0.72.5-2.2-2.3-2.5-2.30.9-0.4
Std. dev. reaction times0.41.33.31.21.11.0-1.80.9-1.2-1.2-1.0-1.1-0.3-1.3
Reaction time trials completed0.41.22.01.01.11.1-0.61.2-1.2-1.0-1.4-1.31.1-0.8
Reaction time trials AUC0.20.81.50.80.80.9-0.41.0-1.0-0.8-1.2-1.11.0-0.6
Run reversals in cocaine runway, females0.91.04.9-0.2-0.1-0.31.3-0.40.80.90.50.7-1.22.2
Run reversals in cocaine runway, males0.80.94.10.40.50.7-0.20.9-0.9-0.8-1.0-1.12.0-0.8
Latency to leave start box in cocaine runway0.60.81.7-0.6-0.8-0.90.4-1.00.91.00.90.9-1.30.7
Latency to leave start box in cocaine runway, F0.50.61.1-0.5-0.6-0.70.7-0.80.70.90.70.8-1.01.0
Latency to leave start box in cocaine runway, M0.10.10.20.10.0-0.0-0.5-0.10.10.1-0.00.0-0.5-0.2
Std. dev. time between licks in bursts0.20.31.10.10.30.41.10.4-0.5-0.3-0.40.10.90.8
Total sessions with >9 infusions0.50.71.8-0.5-0.5-0.60.3-0.71.00.90.81.0-1.30.8
Short access day 1 total inactive lever presses0.91.93.0-1.7-1.7-1.61.3-1.51.31.31.31.5-0.10.7
Short access day 10 total inactive lever presses0.00.30.8-0.6-0.5-0.50.9-0.40.60.60.50.40.10.6
Short access day 1 total infusions1.63.24.2-1.8-1.8-1.91.5-1.92.02.01.92.0-1.21.4
Short access day 10 total infusions2.13.46.2-1.4-1.5-1.70.7-1.82.22.22.02.1-2.51.4
Short access total infusions1.52.13.1-1.2-1.2-1.31.0-1.41.81.71.51.7-1.61.3
Short access day 1 locomotion1.11.92.8-1.5-1.5-1.50.9-1.51.61.61.41.7-0.90.8
Short access day 10 total locomotion0.51.92.9-1.4-1.5-1.60.5-1.61.71.61.51.6-1.20.7
Short access total locomotion1.42.23.1-1.6-1.6-1.70.8-1.61.81.71.51.7-1.10.8
One hour access (0.3 mA shock)3.74.47.1-2.7-2.6-2.51.8-2.22.12.12.32.3-0.10.6
Compulsive drug intake1.42.13.31.61.81.80.21.8-1.5-1.5-1.6-1.61.10.2
One hour access (shock baseline)1.95.18.7-2.9-3.0-2.81.0-2.62.32.32.42.5-0.40.0
Social response proportion0.40.51.70.80.70.6-1.30.5-0.4-0.6-0.4-0.1-0.5-1.0
Social responses0.30.40.50.70.70.7-0.60.7-0.5-0.6-0.6-0.50.3-0.7
Social time0.40.60.80.80.80.9-0.50.9-0.8-0.9-0.9-0.60.5-0.6
Soleus weight2.16.310.9-3.3-3.2-2.92.6-2.62.52.52.52.11.01.3
Bone: stiffness0.51.03.11.31.10.8-1.70.5-0.5-0.5-0.3-0.6-1.8-0.5
Tibialis anterior weight8.429.042.76.56.46.2-5.35.9-5.6-5.5-5.4-5.61.4-3.1
Time to tail flick, vehicle, before self-admin0.10.10.60.0-0.0-0.10.1-0.20.60.40.30.3-0.80.5
Time to tail flick, vehicle, after self-admin0.51.13.4-0.2-0.2-0.50.9-0.61.01.11.10.8-1.71.9
Time to tail flick, test, before self-admin4.04.65.7-2.0-2.0-2.02.4-2.02.42.42.32.2-1.42.3
Time to tail flick, test, after self-admin0.20.20.70.30.30.3-0.70.3-0.3-0.5-0.2-0.10.2-0.8
Delta time to tail flick, vehicle, before/after SA0.20.20.90.10.1-0.00.3-0.10.20.30.40.3-1.00.8
Delta time to tail flick, test, before/after SA5.36.68.72.32.32.4-2.72.5-2.8-2.9-2.7-2.62.1-3.0
Tibia length1.95.412.92.22.02.0-3.62.0-2.1-2.3-2.3-2.20.9-3.0
Ambulatory time before self-admin0.10.31.50.40.20.0-1.2-0.1-0.1-0.2-0.2-0.0-1.0-0.7
Ambulatory time after self-admin0.30.50.7-0.6-0.7-0.8-0.4-0.80.70.50.80.7-0.8-0.4
Bone: tissue strength0.00.10.2-0.1-0.1-0.2-0.0-0.20.30.30.20.2-0.50.1
Total heroin consumption2.93.45.72.42.32.1-2.01.9-1.8-1.8-1.9-1.9-0.3-1.2
Bone: trabecular number0.30.64.90.30.2-0.1-0.8-0.30.50.30.60.5-2.20.1
Bone: trabecular spacing0.20.31.1-0.6-0.5-0.41.1-0.30.30.40.20.40.70.7
Bone: trabecular thickness0.81.11.9-1.0-1.1-1.20.8-1.20.91.01.01.2-1.40.9
Bone: trabecular tissue density1.01.73.5-1.9-1.9-1.61.2-1.41.11.11.20.71.30.1
Water consumed over 24 hours0.30.71.21.01.11.0-0.71.0-0.7-0.8-0.6-0.8-0.1-0.5
Number of responses in last shaping day0.00.10.30.00.10.20.60.2-0.2-0.1-0.20.10.40.1