Pacs1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	Pacs1	0.24	0.13	9.9e-05	0.07	0.11	0.02	0.07	1.1e-02	1.4e-03	1.0e-01	9.8e-03
2	BLA	gene expression	Pacs1	0.07	0.06	1.8e-03	0.01	0.04	0.04	0.03	5.7e-02	2.4e-03	5.7e-03	7.8e-03
3	OFC	gene expression	Pacs1	0.16	0.11	4.1e-03	0.04	0.05	0.02	0.03	5.2e-02	2.5e-02	1.3e-01	7.9e-02
4	PL	gene expression	Pacs1	0.14	0.09	5.3e-14	0.13	0.14	0.14	0.13	3.1e-14	1.3e-14	6.0e-15	2.0e-14
5	NAcc	mRNA stability	Pacs1	0.07	0.06	9.7e-05	0.04	0.03	0.02	0.03	6.2e-05	1.4e-04	2.0e-03	2.8e-04
6	NAcc	gene expression	Pacs1	0.04	0.03	6.3e-05	0.03	0.03	0.02	0.03	6.8e-05	5.8e-04	4.8e-03	5.6e-04
7	Adipose	mRNA stability	Pacs1	0.08	0.08	1.2e-03	0.01	0.01	0.01	0.01	9.2e-03	2.3e-02	4.7e-02	4.2e-02
8	Adipose	gene expression	Pacs1	0.22	0.09	2.4e-15	0.11	0.12	0.11	0.12	2.2e-12	8.5e-13	8.5e-12	3.2e-13
9	Brain	gene expression	Pacs1	0.12	0.06	1.6e-12	0.14	0.13	0.13	0.14	5.9e-13	7.1e-12	2.3e-12	1.1e-12
10	LHb	gene expression	Pacs1	0.19	0.12	5.6e-03	0.13	0.06	0.11	0.1	5.2e-04	1.4e-02	1.7e-03	2.1e-03
11	IL	mRNA stability	Pacs1	0.23	0.12	2.0e-03	0.07	0.07	0.03	0.07	1.0e-02	1.0e-02	5.3e-02	7.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.9	1.5	7.1	-0.1	-0.5	-0.5	0.5	1.3	1.3	1.4	0.7	1.3	1.2	-2.7
Area under the delay curve	1.2	1.3	1.8	-0.8	-0.9	-0.9	1.0	1.3	1.3	1.3	1.2	1.3	1.2	-1.2
BMI with tail	0.7	2.2	19.0	1.1	0.6	0.5	-0.0	0.5	0.5	0.8	1.1	0.6	0.5	-4.4
BMI without tail	0.3	0.7	5.6	0.4	0.2	0.1	0.2	0.4	0.4	0.6	1.1	0.4	-0.0	-2.4
Body weight	1.4	6.1	11.6	3.4	3.1	3.0	-2.7	-2.3	-2.3	-2.1	-1.7	-1.8	-2.0	-2.0
Weight adjusted by age	2.4	2.7	3.6	1.9	1.8	1.8	-1.7	-1.8	-1.9	-1.7	-1.5	-1.6	-1.4	-0.1
Bone surface	1.0	1.7	6.5	2.0	1.5	1.5	-1.4	-0.4	-0.4	-0.3	-1.3	-0.3	0.4	-2.5
Bone volume	0.4	0.7	5.2	0.8	0.4	0.4	-0.3	0.3	0.3	0.4	-0.4	0.4	0.9	-2.3
Breakpoint value in progressive ratio session	2.5	2.7	4.1	2.0	1.9	1.9	-1.8	-1.6	-1.7	-1.7	-1.7	-1.7	-1.0	-0.3
Number of licking bursts	0.2	0.2	0.3	0.6	0.5	0.5	-0.4	-0.4	-0.4	-0.4	-0.5	-0.4	-0.1	-0.2
Context. condit. distance diff. score	1.5	1.8	2.9	-1.7	-1.6	-1.6	1.5	1.3	1.3	1.3	1.7	1.1	0.7	0.2
Locomotion velocity, session 1	0.1	0.1	0.3	0.1	0.2	0.3	-0.4	-0.4	-0.4	-0.4	-0.1	-0.3	-0.3	0.6
Locomotion distance, session 1	0.4	0.6	3.2	0.1	-0.1	-0.1	0.1	0.5	0.5	0.7	0.7	0.8	1.0	-1.8
Locomotion velocity, session 2	1.0	1.1	2.1	1.5	1.3	1.3	-1.1	-1.1	-1.1	-1.0	-0.6	-0.7	-0.7	-1.0
Locomotion distance, session 2	0.2	0.3	2.5	0.5	0.3	0.3	-0.2	-0.0	-0.0	0.1	0.3	0.6	0.2	-1.6
Locomotion velocity, session 3	0.5	0.6	1.0	-0.7	-0.7	-0.7	0.8	0.7	0.7	0.7	1.0	0.7	1.0	-0.8
Locomotion distance, session 3	0.0	0.0	0.1	-0.2	-0.1	-0.2	0.2	0.1	0.1	-0.0	0.1	0.1	0.3	-0.0
Stereotopy head waving bouts, day 3	1.5	1.8	2.5	-1.3	-1.3	-1.3	1.3	1.4	1.4	1.4	1.5	1.6	1.0	-0.9
Stereotopy head waving duration, day 3	1.5	1.8	2.3	-1.4	-1.4	-1.4	1.3	1.5	1.5	1.5	1.3	1.5	1.2	-0.6
Locomotion velocity, session 7	1.6	1.7	2.8	-1.1	-1.2	-1.3	1.5	1.2	1.2	1.3	1.7	1.4	1.2	-1.3
Locomotion distance, session 7	0.3	0.4	0.9	-0.4	-0.4	-0.5	0.6	0.5	0.5	0.8	1.0	0.6	0.1	-0.8
Stereotopy head waving bouts, day 7	0.6	0.6	1.0	-0.7	-0.8	-0.8	0.9	0.9	0.9	0.7	0.5	0.9	1.0	-0.7
Stereotopy head waving duration, day 7	0.2	0.3	2.1	0.5	0.3	0.2	-0.1	0.3	0.3	0.2	-0.2	0.2	0.5	-1.4
Locomotion velocity, session 8	0.9	1.1	1.8	1.2	1.2	1.2	-1.3	-0.9	-0.9	-1.0	-1.0	-0.9	-1.1	0.1
Locomotion distance, session 8	0.5	0.7	1.3	-0.9	-0.8	-0.9	1.0	0.7	0.7	0.7	1.1	0.9	0.7	-0.5
Degree of sensitization distance	0.4	0.4	1.0	-0.3	-0.4	-0.4	0.5	0.6	0.6	0.9	0.8	0.7	0.1	-1.0
Degree of sensitization stereotypy	0.1	0.1	0.4	0.5	0.3	0.3	-0.1	-0.1	-0.1	-0.2	-0.5	-0.1	0.1	-0.6
Conditioned locomotion	1.8	2.2	3.2	1.6	1.7	1.6	-1.4	-1.7	-1.7	-1.7	-1.0	-0.9	-1.8	0.3
Cocaine response after cond. corrected	0.9	1.0	1.7	-1.3	-1.2	-1.1	1.1	0.9	0.9	1.0	1.3	1.1	0.3	0.3
Cocaine response after cond. not corrected	0.9	0.9	1.3	-1.2	-1.1	-1.1	1.0	1.0	1.0	1.1	1.1	0.9	0.6	0.1
Cocaine response before conditioning	0.4	0.5	1.1	0.8	0.7	0.7	-0.8	-0.4	-0.4	-0.5	-1.0	-1.0	0.2	-0.3
Saline control response	1.9	2.5	4.8	2.2	1.9	2.0	-2.0	-1.1	-1.1	-1.1	-1.6	-1.1	-1.3	-1.2
Bone: connectivity density	0.7	1.1	8.0	1.1	0.6	0.6	-0.5	0.4	0.4	0.6	-0.2	0.6	0.8	-2.8
Bone: cortical apparent density	0.3	0.3	0.7	0.6	0.6	0.6	-0.6	-0.6	-0.6	-0.5	-0.5	-0.4	-0.8	0.2
Bone: cortical area	1.0	1.5	2.3	1.2	1.3	1.3	-1.1	-1.5	-1.5	-1.4	-1.2	-1.3	-0.9	0.5
Bone: cortical porosity	0.4	0.4	1.4	-0.1	-0.3	-0.3	0.3	0.6	0.6	0.7	0.7	0.8	0.6	-1.2
Bone: cortical porosity	0.2	0.2	1.4	0.4	0.2	0.2	-0.2	0.2	0.2	0.3	0.2	0.4	0.1	-1.2
Bone: cortical thickness	4.7	7.7	9.7	2.8	3.0	2.9	-2.7	-3.1	-3.1	-3.0	-2.3	-2.9	-3.1	1.2
Bone: cortical thickness	1.9	2.2	3.9	1.3	1.5	1.5	-1.4	-1.6	-1.6	-1.5	-1.1	-1.4	-2.0	1.0
Bone: cortical tissue density	0.4	0.5	0.9	0.7	0.7	0.7	-0.7	-0.7	-0.7	-0.6	-0.6	-0.5	-1.0	0.2
Condit. Reinf. active minus inactive responses	0.0	0.0	0.3	0.2	0.1	0.1	-0.1	-0.1	-0.1	-0.1	0.2	-0.0	0.1	-0.5
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.0	-0.0	-0.0	-0.0	-0.0	-0.0	-0.0	0.1	0.0	0.4	-0.2
Condit. Reinf. active responses	0.0	0.0	0.1	0.1	0.1	0.0	0.1	-0.2	-0.2	-0.1	0.4	0.1	-0.0	-0.4
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.3	-0.2	-0.3	0.5	0.0	0.0	0.2	0.6	0.4	0.0	-0.3
Incentive salience index mean	0.1	0.1	0.6	0.2	0.2	0.1	0.0	-0.2	-0.2	-0.0	0.4	0.1	0.2	-0.8
Condit. Reinf. lever presses	0.2	0.2	0.6	0.5	0.5	0.4	-0.3	-0.8	-0.8	-0.5	-0.1	-0.5	-0.1	-0.0
Condit. Reinf. active minus inactive responses	0.4	0.5	1.6	-0.5	-0.7	-0.6	0.5	0.8	0.8	0.7	0.2	0.6	1.3	-0.7
Condit. Reinf. active-inactive response ratio	0.7	0.8	2.3	-1.0	-0.9	-1.0	1.0	0.7	0.7	0.6	0.4	0.8	1.5	-0.2
Condit. Reinf. active responses	0.5	0.8	2.3	-0.2	-0.5	-0.5	0.3	1.0	1.0	1.0	0.3	0.8	1.3	-1.5
Condit. Reinf. inactive responses	0.5	0.6	3.2	0.2	-0.2	-0.1	-0.1	1.0	1.0	1.0	0.5	0.5	0.5	-1.8
Condit. Reinf. lever presses	1.0	1.4	2.8	1.7	1.4	1.4	-1.4	-0.9	-0.9	-1.0	-1.4	-1.1	-0.2	-0.9
Condit. Reinf. lever reinforcers received	0.3	0.4	2.0	0.2	-0.1	-0.1	-0.1	0.7	0.7	0.6	-0.1	0.4	1.0	-1.4
Conditioned reinforcement - actives	0.0	0.0	0.3	-0.2	-0.1	-0.1	-0.0	0.0	0.1	0.0	-0.2	-0.3	0.2	0.6
Conditioned reinforcement - inactives	2.8	3.1	5.5	-2.3	-2.2	-2.1	2.0	1.5	1.5	1.5	1.2	1.4	2.0	1.1
Conditioned locomotion	2.9	3.5	7.3	-2.7	-2.4	-2.3	2.1	1.4	1.4	1.4	1.5	1.4	1.5	1.9
Patch foraging indifference point 0 sec	0.1	0.2	0.5	-0.3	-0.4	-0.4	0.3	0.5	0.5	0.5	0.3	0.5	0.7	-0.3
Patch foraging indifference point AUC	2.9	3.3	4.8	2.2	2.1	2.1	-2.0	-1.7	-1.7	-1.8	-2.1	-1.6	-1.8	-0.2
Delay disc. indifference point, 0s delay	2.1	2.3	3.4	-1.4	-1.5	-1.4	1.5	1.7	1.7	1.7	1.8	1.8	0.7	-1.2
Delay disc. indifference point, 16s delay	1.6	1.6	3.3	-1.2	-1.3	-1.3	1.4	1.1	1.1	1.2	1.1	1.3	1.8	-0.6
Delay disc. indifference point, 2s delay	0.2	0.3	0.4	-0.6	-0.6	-0.6	0.5	0.5	0.5	0.6	0.5	0.3	0.6	-0.2
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.2	-0.2	-0.1	0.2	0.2	0.2	0.2	0.3	0.4	-0.2	0.1
Delay disc. indifference point, 4s delay	1.0	1.1	1.9	-0.8	-0.9	-0.9	0.9	1.3	1.4	1.2	1.2	1.1	0.5	-0.9
Delay disc. indifference point, 8s delay	0.8	0.8	1.8	-0.6	-0.7	-0.6	0.7	1.1	1.0	1.0	0.9	1.3	0.7	-1.0
Indifference point function ln k	4.8	6.7	12.0	-3.5	-3.1	-3.1	3.0	2.2	2.2	2.1	3.0	2.1	1.9	1.1
Indifference point function log k	4.8	6.7	12.0	-3.5	-3.1	-3.1	3.0	2.2	2.2	2.1	3.0	2.1	1.9	1.1
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.0	0.1	0.1	0.0	0.0	0.1	0.1	0.2
Patch foraging total patch changes 12 sec	2.3	3.0	5.7	2.4	2.1	2.1	-2.1	-1.4	-1.4	-1.4	-1.7	-1.3	-1.5	-1.2
Patch foraging total patch changes 18 sec	0.2	0.2	0.7	0.6	0.5	0.5	-0.4	-0.1	-0.1	-0.1	-0.4	0.0	-0.5	-0.8
Patch foraging total patch changes 24 sec	2.1	2.6	3.9	2.0	1.9	1.9	-1.9	-1.4	-1.4	-1.5	-1.8	-1.4	-1.5	-0.1
Patch foraging total patch changes 6 sec	0.4	0.6	1.3	1.1	0.9	0.9	-0.9	-0.4	-0.4	-0.4	-0.7	-0.2	-0.5	-1.1
Patch foraging time to switch 0 sec	0.4	0.6	4.7	0.9	0.6	0.5	-0.2	-0.1	-0.1	0.1	0.2	0.2	0.6	-2.2
Patch foraging water rate 0 sec	0.9	1.4	7.4	-1.7	-1.3	-1.3	1.0	0.4	0.4	0.2	0.3	0.3	0.1	2.7
Patch foraging water rate 12 sec	2.3	3.5	7.9	-2.8	-2.4	-2.3	1.9	1.5	1.5	1.3	1.4	1.1	0.5	2.6
Patch foraging water rate 18 sec	1.2	1.6	3.3	-1.8	-1.6	-1.5	1.3	1.1	1.1	1.0	1.3	1.1	0.7	1.1
Patch foraging water rate 24 sec	1.1	1.6	4.7	-1.9	-1.5	-1.5	1.3	0.7	0.7	0.4	1.0	0.7	0.1	2.2
Patch foraging water rate 6 sec	0.8	1.2	4.0	-1.6	-1.3	-1.2	1.0	0.6	0.6	0.4	0.8	0.8	-0.1	2.0
Seeking ratio, delayed vs. immediate footshock	0.5	0.5	0.9	-0.4	-0.6	-0.6	0.6	0.8	0.6	0.8	0.7	0.8	0.9	-1.0
Distance traveled before self-admin	0.3	0.3	0.4	0.6	0.6	0.6	-0.5	-0.7	-0.7	-0.6	-0.6	-0.5	-0.2	-0.0
Distance traveled after self-admin	0.2	0.3	0.5	0.5	0.5	0.4	-0.5	-0.7	-0.7	-0.5	-0.7	-0.4	-0.0	0.1
Extensor digitorum longus weight	4.4	17.3	27.6	5.3	5.0	4.9	-4.4	-4.3	-4.3	-3.9	-3.3	-3.9	-3.9	-1.2
Bone: elastic displacement	0.3	0.4	2.5	-0.3	-0.0	0.0	-0.1	-0.4	-0.4	-0.5	-0.0	-0.1	-1.0	1.6
Bone: elastic work	1.6	2.1	4.4	1.4	1.5	1.5	-1.4	-1.6	-1.6	-1.5	-1.0	-1.2	-2.1	0.7
Bone: endosteal estimation	2.0	4.3	4.9	-2.0	-2.1	-2.1	2.2	2.1	2.1	2.1	1.9	2.2	2.2	-1.4
Bone: endosteal perimeter	2.7	5.5	11.5	-2.2	-2.4	-2.4	2.3	2.4	2.4	2.4	1.9	2.3	3.4	-1.6
Epididymis fat weight	2.4	5.5	7.8	-2.8	-2.7	-2.7	2.6	2.4	2.4	2.3	2.2	2.2	2.1	-0.0
Delta time in closed arm before/after self-admin	0.2	0.2	1.3	0.3	0.3	0.3	-0.3	-0.2	-0.2	-0.2	0.3	0.0	-1.1	-0.2
Delta time in open arm before/after self-admin	0.2	0.2	0.8	0.3	0.3	0.3	-0.3	-0.3	-0.3	-0.4	-0.9	-0.7	-0.1	0.5
Diff in mean of infusions in LGA sessions	0.9	0.9	1.3	1.0	1.0	1.0	-1.0	-1.0	-1.0	-1.0	-1.1	-1.0	-0.9	0.5
Delay discount exponential model param	0.9	0.9	1.3	0.6	0.8	0.8	-0.8	-1.2	-1.1	-1.1	-1.0	-1.1	-1.0	1.0
Extinction: sum of active levers before priming	1.8	1.8	3.6	1.9	1.7	1.6	-1.4	-1.1	-1.1	-1.3	-1.1	-1.2	-0.7	-1.2
Active lever presses in extinction session 6	4.2	4.1	5.8	2.0	2.0	2.0	-2.0	-2.4	-2.4	-2.2	-2.2	-2.1	-1.6	1.0
Bone: final force	1.3	2.2	3.8	2.0	1.8	1.8	-1.7	-1.4	-1.5	-1.3	-1.4	-1.3	-1.0	-0.7
Bone: final moment	1.2	1.9	3.4	1.8	1.7	1.7	-1.5	-1.3	-1.3	-1.2	-1.3	-1.2	-0.9	-0.7
Food consumed during 24 hour testing period	0.4	0.5	1.1	0.5	0.5	0.6	-0.6	-0.7	-0.7	-0.8	-1.0	-0.7	-0.4	0.8
Glucose	3.7	5.6	6.9	-2.3	-2.4	-2.4	2.4	2.5	2.5	2.5	2.3	2.6	2.3	-1.4
Heart weight	2.9	4.1	5.5	-2.4	-2.3	-2.3	2.2	2.1	2.1	2.2	1.9	2.3	1.4	-0.1
Delay discount hyperbolic model param	0.7	0.8	1.2	0.6	0.7	0.7	-0.7	-1.1	-1.0	-1.0	-0.9	-1.0	-0.9	0.9
Intermittent access intake day 1-15 change	0.3	0.3	1.4	-0.2	0.0	0.0	-0.1	-0.7	-0.7	-0.6	-0.5	-0.4	-0.2	1.2
Intermittent access intake escalation	0.1	0.1	0.5	-0.3	-0.2	-0.2	0.2	-0.3	-0.4	-0.3	-0.1	-0.0	0.1	0.7
Intermittent access intake escalation 2	0.4	0.4	1.5	0.1	0.3	0.3	-0.3	-0.8	-0.8	-0.8	-0.7	-0.6	-0.5	1.2
Intermitt. access day 1 inactive lever presses	1.5	1.6	2.4	-1.6	-1.5	-1.5	1.6	1.0	1.1	1.0	1.1	1.3	1.5	0.5
Intermitt. access day 15 inactive lever presses	1.0	1.1	2.0	-1.3	-1.3	-1.3	1.3	0.8	0.7	0.8	0.8	0.9	1.4	0.5
Intermitt. access escalation Index	5.2	4.6	5.8	-2.3	-2.3	-2.3	2.2	2.3	2.3	2.3	2.4	2.1	1.5	-0.7
Intermittent access day 1 total infusions	9.8	11.4	14.0	-3.2	-3.4	-3.4	3.4	3.7	3.7	3.7	3.4	3.4	3.5	-1.8
Intermittent access day 15 total infusions	6.2	7.0	9.4	-3.1	-3.0	-3.0	2.9	2.6	2.6	2.6	2.5	2.5	2.8	-0.1
Intermittent access terminal intake (last 3 days)	5.2	5.7	7.0	-2.6	-2.6	-2.6	2.6	2.5	2.4	2.4	2.2	2.3	2.6	-0.4
Intermittent access total infusions	6.4	7.2	8.5	-2.6	-2.8	-2.8	2.7	2.9	2.8	2.9	2.7	2.6	2.9	-1.2
Intermittent access day 1 locomotion	8.1	8.5	10.8	-2.6	-2.8	-2.8	2.8	3.3	3.2	3.3	3.2	2.9	2.9	-1.9
Intermittent access day 15 total locomotion	4.2	4.5	5.9	-2.4	-2.4	-2.4	2.3	2.1	2.1	2.1	2.0	2.0	2.4	-0.3
Intermittent access total locomotion	9.2	10.5	13.4	-3.3	-3.4	-3.4	3.4	3.4	3.3	3.4	3.2	3.2	3.7	-1.4
Intermittent access standard deviation	0.3	0.3	0.6	-0.8	-0.7	-0.7	0.6	0.2	0.3	0.3	0.4	0.5	0.3	0.6
Left kidney weight	0.2	0.7	1.6	-1.2	-0.9	-1.0	1.2	0.1	0.1	0.0	0.8	0.7	0.2	1.2
Right kidney weight	0.2	0.6	3.2	-0.1	0.2	0.1	0.1	-0.9	-0.9	-1.0	-0.6	-0.8	-0.2	1.8
Cocaine induced anxiety	0.1	0.1	0.4	0.2	0.2	0.2	-0.1	-0.3	-0.3	-0.4	-0.4	-0.3	-0.3	0.6
Post-drug Anxiety	2.4	2.7	4.0	1.6	1.7	1.6	-1.5	-1.7	-1.7	-1.8	-2.0	-1.6	-1.4	1.1
Baseline Anxiety	2.8	2.9	3.6	1.9	1.9	1.9	-1.9	-1.7	-1.8	-1.7	-1.9	-1.8	-1.5	0.3
Tail length	1.7	5.1	6.5	2.0	2.2	2.2	-2.3	-2.4	-2.4	-2.5	-2.0	-2.2	-2.5	1.8
Length with tail	2.7	10.0	12.4	3.5	3.5	3.5	-3.4	-3.4	-3.4	-3.4	-3.1	-2.9	-3.1	1.0
Length without tail	2.2	4.8	7.4	2.7	2.6	2.6	-2.6	-2.1	-2.1	-2.2	-2.4	-1.9	-1.7	-0.2
Times rat made contact with spout	0.1	0.1	0.8	0.5	0.3	0.3	-0.4	-0.0	-0.0	0.1	0.0	0.1	-0.0	-0.9
Lifetime Intake	6.3	7.2	8.9	-2.6	-2.7	-2.7	2.7	3.0	2.9	3.0	2.8	2.6	2.7	-1.4
Liver weight, left	0.0	0.1	0.2	-0.3	-0.2	-0.2	0.2	0.1	0.1	-0.1	0.2	-0.1	-0.2	0.4
Liver weight, right	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.1	0.3	0.3	0.0	0.3	-0.0	-0.2	0.1
Locomotor activity	0.3	0.5	2.0	-1.1	-0.8	-0.8	0.5	0.5	0.5	0.3	0.5	0.2	-0.1	1.4
Locomotor testing distance	0.5	0.9	2.0	-1.4	-1.2	-1.1	0.7	0.8	0.8	0.7	0.8	0.5	-0.0	1.4
Locomotor testing rearing	1.3	2.0	3.3	-1.6	-1.7	-1.5	1.1	1.8	1.8	1.6	1.3	1.3	0.7	0.1
Locomotion in novel chamber	2.5	3.1	5.4	-2.3	-2.1	-2.2	2.1	1.5	1.5	1.4	1.4	1.4	2.0	0.9
Locomotion in novel chamber post-restriction	1.6	2.0	3.5	-1.9	-1.7	-1.7	1.6	1.2	1.2	1.3	1.3	1.2	1.2	0.6
Fecal boli incidents, locomotor time 1	0.1	0.2	0.4	0.2	0.3	0.2	-0.2	-0.3	-0.4	-0.3	-0.7	-0.6	-0.1	0.5
Change in fecal boli incidents, locomotor task	0.4	0.4	0.8	-0.2	-0.4	-0.3	0.3	0.6	0.8	0.6	0.7	0.7	0.6	-0.9
Time >=10cm from walls, locomotor time 1	2.8	2.8	6.2	-1.4	-1.5	-1.6	1.7	1.8	1.7	1.6	1.4	1.7	2.5	-1.3
Bouts of movement, locomotor time 1	1.2	1.3	1.9	1.3	1.2	1.2	-1.2	-1.3	-1.3	-1.1	-1.4	-0.9	-0.6	0.0
Total resting periods, locomotor time 1	0.7	0.7	1.2	1.1	1.0	0.9	-0.9	-0.9	-1.0	-0.8	-1.1	-0.7	-0.2	-0.1
Rest time, locomotor task time 1	0.4	0.4	1.4	-1.0	-0.8	-0.8	0.6	0.1	0.1	0.2	0.4	0.3	0.6	1.2
Distance moved, locomotor task time 1	0.3	0.3	1.6	-0.1	-0.2	-0.3	0.3	0.6	0.6	0.6	0.6	0.6	0.4	-1.3
Vertical activity count, locomotor time 1	0.6	0.7	1.1	-1.0	-1.0	-1.0	1.0	0.8	0.9	0.8	0.8	0.6	0.4	0.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.4	-0.1	-0.1	-0.1	0.3	0.1	0.1	-0.1	0.0	0.2	0.6	-0.2
Bouts of movement, locomotor time 2	0.3	0.3	0.6	0.8	0.7	0.7	-0.6	-0.4	-0.4	-0.4	-0.6	-0.4	-0.4	-0.3
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.5	0.4	0.4	-0.2	-0.1	-0.2	-0.1	-0.3	-0.0	-0.0	-0.4
Rest time, locomotor task time 2	1.7	2.0	3.2	-1.8	-1.7	-1.7	1.7	1.2	1.1	1.2	1.4	1.5	1.2	0.3
Distance moved, locomotor task time 2	1.1	1.2	1.6	1.3	1.2	1.2	-1.2	-1.2	-1.1	-1.2	-1.1	-1.2	-0.8	0.0
Vertical activity count, locomotor time 2	1.0	1.1	2.0	0.6	0.8	0.8	-0.9	-1.0	-0.9	-1.1	-1.0	-1.2	-1.4	1.3
Light reinforcement 1	0.1	0.1	0.2	-0.4	-0.4	-0.3	0.1	0.4	0.4	0.3	0.0	0.2	0.1	0.3
Light reinforcement 2	0.3	0.4	1.4	-0.9	-0.7	-0.7	0.7	0.0	0.0	0.1	0.0	-0.0	0.9	1.2
Bone: marrow area	2.1	4.5	5.3	-2.1	-2.2	-2.2	2.3	2.2	2.2	2.2	2.0	2.3	2.2	-1.4
Bone: maximum diameter	0.2	0.4	0.8	0.5	0.6	0.5	-0.5	-0.7	-0.7	-0.7	-0.9	-0.7	0.4	0.4
Bone: maximum force	0.8	1.4	3.5	1.8	1.5	1.4	-1.2	-0.9	-0.9	-0.8	-0.9	-0.5	-0.0	-1.9
Bone: maximum moment	0.7	1.2	3.1	1.6	1.3	1.3	-1.1	-0.8	-0.8	-0.7	-0.8	-0.5	-0.0	-1.8
Mean time between licks in bursts	0.3	0.4	1.1	0.8	0.8	0.8	-1.0	-0.4	-0.4	-0.4	-0.6	-0.5	-0.7	-0.2
Mean num. licks in bursts	0.3	0.4	0.6	-0.6	-0.6	-0.6	0.5	0.7	0.7	0.8	0.7	0.7	0.4	-0.4
Cd content in liver	0.3	0.3	1.2	-0.8	-0.7	-0.7	0.6	0.4	0.4	0.0	-0.1	0.2	0.5	1.1
Co content in liver	0.3	0.3	1.6	-0.8	-0.5	-0.4	0.3	0.3	0.3	0.1	0.2	0.2	-0.9	1.3
Cu content in liver	0.1	0.1	0.3	0.4	0.3	0.3	-0.2	-0.2	-0.2	-0.2	-0.1	-0.2	-0.1	-0.6
Fe content in liver	0.3	0.3	0.6	0.5	0.5	0.5	-0.5	-0.6	-0.6	-0.5	-0.8	-0.7	-0.6	0.3
K content in liver	0.4	0.4	2.5	0.8	0.6	0.5	-0.3	-0.2	-0.2	-0.0	0.2	0.0	0.3	-1.6
Mg content in liver	1.8	1.8	5.5	-0.5	-0.9	-0.9	0.9	1.4	1.4	1.5	1.3	1.4	1.6	-2.3
Mn content in liver	1.6	1.8	3.2	1.8	1.6	1.6	-1.5	-1.3	-1.3	-1.3	-1.5	-1.1	-0.7	-0.4
Na content in liver	1.7	1.8	2.9	1.3	1.4	1.3	-1.3	-1.6	-1.6	-1.5	-1.3	-1.7	-0.8	0.8
Rb content in liver	3.0	3.7	5.0	-1.8	-2.0	-1.9	1.8	2.2	2.2	2.2	1.8	2.1	1.7	-1.4
Se content in liver	0.2	0.3	1.0	-0.1	-0.3	-0.3	0.3	0.5	0.5	0.4	-0.1	0.6	1.0	-0.9
Sr content in liver	4.3	3.9	4.7	2.1	2.1	2.1	-2.1	-2.1	-2.1	-2.0	-2.2	-2.0	-1.8	1.0
Zn content in liver	0.5	0.5	0.9	1.0	0.9	0.8	-0.7	-0.7	-0.7	-0.7	-0.5	-0.7	-0.6	-0.6
Bone: minimum diameter	2.5	4.7	5.5	-1.9	-2.1	-2.1	2.3	2.2	2.2	2.3	2.2	2.4	2.3	-1.9
Time in familiar zone, hab. session 1	0.6	0.6	1.5	-0.7	-0.7	-0.8	0.7	0.7	0.7	0.8	0.7	0.4	1.2	-0.4
Time in novel zone, hab. session 1	0.1	0.1	0.8	-0.1	0.0	0.1	-0.2	-0.0	-0.0	-0.2	-0.2	0.1	-0.9	0.6
Total zone transitions, hab. session 1	0.3	0.4	0.7	0.8	0.8	0.7	-0.6	-0.6	-0.6	-0.5	-0.3	-0.5	-0.3	-0.6
Total locomotion distance, hab. session 1	0.4	0.6	1.2	-0.9	-0.9	-0.9	1.0	0.6	0.6	0.7	1.1	0.8	0.6	-0.3
Locomotion velocity, hab. session 1	0.1	0.2	0.5	-0.4	-0.4	-0.4	0.6	0.2	0.2	0.4	0.7	0.4	0.3	-0.4
Time in familiar zone, hab. session 2	0.2	0.2	0.9	0.2	0.3	0.4	-0.5	-0.2	-0.2	-0.3	-0.1	-0.4	-1.0	0.4
Time in novel zone, hab. session 2	0.3	0.3	0.9	-0.2	-0.3	-0.3	0.4	0.5	0.5	0.6	0.3	0.6	0.9	-0.9
Total zone transitions, hab. session 2	1.1	1.5	9.3	0.3	-0.2	-0.2	0.1	1.1	1.1	1.1	0.8	1.3	1.0	-3.1
Total locomotion distance, hab. session 2	1.3	1.8	3.5	-0.9	-1.1	-1.1	1.1	1.4	1.4	1.4	1.5	1.6	1.0	-1.9
Locomotion velocity, hab. session 2	1.5	2.0	3.1	-1.0	-1.2	-1.2	1.3	1.4	1.4	1.4	1.6	1.6	1.2	-1.7
Novel to familiar place preference ratio	0.3	0.3	0.7	0.8	0.6	0.6	-0.5	-0.4	-0.4	-0.5	-0.8	-0.4	0.3	-0.6
Novelty place preference	0.1	0.1	0.3	0.4	0.3	0.2	-0.2	-0.1	-0.1	-0.2	-0.5	-0.1	0.6	-0.5
Time in novel zone, NPP test	0.1	0.1	0.3	0.3	0.2	0.1	-0.1	0.0	0.0	-0.1	-0.4	0.1	0.5	-0.6
Total zone transitions, NPP test	0.5	0.7	2.2	1.2	1.0	1.0	-0.9	-0.5	-0.5	-0.4	-0.3	-0.5	-0.2	-1.5
Total locomotion distance, NPP test	0.2	0.2	0.7	-0.3	-0.3	-0.4	0.5	0.3	0.3	0.4	0.7	0.5	0.2	-0.8
Locomotion velocity, NPP test	0.1	0.1	0.5	-0.2	-0.2	-0.2	0.4	0.1	0.1	0.2	0.6	0.3	0.2	-0.7
Intraocular pressure	0.3	0.4	3.0	-0.5	-0.2	-0.2	0.3	-0.2	-0.2	-0.3	-0.7	-0.1	-0.1	1.7
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.1	-0.1	-0.1	-0.0	0.0	0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.1	0.2	0.2	-0.3	-0.2	-0.2	-0.1	-0.2	-0.1	-0.2	0.0
Parametrial fat weight	3.2	6.2	8.6	-2.8	-2.7	-2.8	2.9	2.6	2.6	2.6	2.5	2.5	2.1	-0.8
Pavlov. Cond. lever latency	0.0	0.0	0.1	-0.3	-0.2	-0.2	0.1	0.2	0.2	0.0	0.0	0.2	-0.1	0.4
Pavlov. Cond. magazine entry latency	0.4	0.5	1.5	-0.3	-0.4	-0.5	0.5	0.6	0.6	0.7	0.6	0.7	1.2	-1.2
Pavlov. Cond. change in total contacts	0.1	0.1	1.0	-0.2	-0.2	-0.3	0.4	-0.0	-0.0	0.0	0.0	-0.1	1.0	-0.2
Pavlov. Cond. index score	0.0	0.0	0.1	0.2	0.2	0.1	-0.1	-0.3	-0.3	-0.1	-0.2	-0.3	0.4	0.0
Pavlov. Cond. latency score	0.0	0.0	0.2	-0.1	-0.1	-0.1	0.2	0.0	0.0	0.2	0.1	-0.0	0.5	-0.2
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.2	-0.0	-0.0	0.2	0.1	-0.1	0.1	-0.1
Pavlov. Cond. magazine entry number	0.2	0.3	0.5	-0.5	-0.5	-0.4	0.4	0.6	0.6	0.7	0.7	0.7	-0.1	-0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.6	-0.2	-0.1	-0.1	0.1	-0.1	-0.1	-0.2	-0.1	-0.2	-0.4	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.3	0.3	0.3	-0.2	-0.4	-0.4	-0.2	-0.3	-0.4	0.3	-0.1
Pavlov. Cond. response bias	0.1	0.1	0.2	0.3	0.3	0.2	-0.2	-0.4	-0.4	-0.4	-0.4	-0.5	0.2	0.3
Pavlov. Cond. lever latency	0.3	0.4	0.6	-0.8	-0.7	-0.7	0.6	0.6	0.6	0.7	0.7	0.6	0.1	0.3
Pavlov. Cond. magazine entry latency	1.3	1.5	3.2	1.8	1.5	1.5	-1.4	-1.0	-1.0	-0.8	-1.1	-1.0	-0.3	-1.4
Pavlov. Cond. change in total contacts	0.7	0.9	1.8	1.4	1.1	1.1	-0.9	-0.8	-0.8	-0.9	-1.2	-0.7	0.5	-1.0
Pavlov. Cond. index score	1.0	1.3	2.5	1.6	1.4	1.3	-1.2	-1.1	-1.1	-1.0	-1.2	-1.0	-0.1	-0.9
Pavlov. Cond. latency score	0.9	1.1	2.0	1.4	1.3	1.2	-1.0	-1.1	-1.1	-1.0	-1.0	-0.9	-0.1	-0.8
Pavlov. Cond. lever contacts	0.6	0.8	1.4	1.0	1.0	1.0	-1.0	-0.9	-0.9	-1.0	-1.2	-1.1	-0.3	0.2
Pavlov. Cond. magazine entry number	2.6	3.2	6.6	-2.6	-2.2	-2.2	2.1	1.5	1.5	1.4	1.8	1.4	0.7	1.6
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.5	-1.2	-1.1	-1.1	1.0	0.8	0.8	0.8	0.9	0.6	0.6	0.6
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.6	3.1	1.8	1.5	1.5	-1.4	-1.2	-1.2	-1.1	-1.2	-1.1	-0.3	-1.0
Pavlov. Cond. response bias	1.0	1.4	2.5	1.6	1.4	1.4	-1.4	-1.0	-1.0	-1.0	-1.4	-1.2	-0.3	-0.6
Time in closed arm before self-admin	0.1	0.1	0.5	-0.1	-0.1	-0.1	0.2	0.2	0.2	0.2	-0.3	0.1	0.7	-0.2
Time in closed arm after self-admin	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.2	0.0	0.0	0.2	0.4	0.3	-0.0	-0.2
Time in open arm before self-admin	0.5	0.5	1.7	-0.7	-0.7	-0.6	0.6	0.7	0.6	0.7	1.3	0.9	-0.2	-0.3
Time in open arm after self-admin	0.1	0.1	0.5	-0.2	-0.1	-0.0	-0.0	0.0	-0.0	-0.1	-0.2	-0.3	-0.4	0.7
Bone: periosteal estimation	0.1	0.1	0.3	-0.4	-0.3	-0.4	0.6	0.2	0.2	0.2	0.3	0.4	0.5	-0.3
Bone: periosteal perimeter	0.1	0.2	0.8	0.1	-0.1	-0.1	0.1	0.2	0.2	0.2	-0.1	0.3	0.9	-0.8
Bone: post-yield work	3.3	4.5	12.6	-0.9	-1.4	-1.5	1.7	1.9	1.9	2.1	1.7	2.2	3.2	-3.5
Progressive ratio test 1 active lever presses	2.2	2.3	3.1	-1.8	-1.8	-1.7	1.6	1.6	1.5	1.7	1.6	1.3	1.5	-0.1
Progressive ratio test 1 breakpoint	1.7	1.8	2.5	-1.6	-1.6	-1.5	1.4	1.4	1.3	1.5	1.4	1.1	1.3	0.0
Progressive ratio test 1 inactive lever presses	1.3	1.5	1.8	-1.3	-1.3	-1.3	1.2	1.3	1.2	1.3	1.3	1.2	1.1	-0.3
Progressive ratio test 2 active lever presses	3.2	3.5	4.5	-2.1	-2.1	-2.1	2.0	1.9	1.9	1.9	1.8	1.6	2.1	-0.1
Progressive ratio test 2 breakpoint	2.9	3.3	5.1	-2.3	-2.2	-2.1	2.0	1.8	1.8	1.8	1.7	1.5	1.9	0.4
Progressive ratio test 2 inactive lever presses	7.7	8.9	11.3	-3.4	-3.4	-3.3	3.2	3.2	3.1	3.1	2.6	2.9	3.1	-0.2
Incentive Sensitization - Responses	0.5	0.5	1.0	-0.6	-0.7	-0.7	0.7	0.8	0.8	0.7	0.7	0.6	1.0	-0.4
Incentive Sensitization - Breakpoint	0.6	0.6	1.1	-0.8	-0.8	-0.8	0.8	0.7	0.8	0.7	0.7	0.6	1.1	-0.3
Sum of active levers in priming session hrs 5-6	5.4	5.2	7.3	2.0	2.2	2.1	-2.1	-2.6	-2.6	-2.7	-2.6	-2.6	-1.6	1.8
Progressive ratio	0.6	0.7	5.7	0.6	0.2	0.2	-0.0	0.6	0.5	0.6	0.4	0.6	0.6	-2.4
Food seeking constrained by brief footshock	0.3	0.4	0.6	0.6	0.6	0.6	-0.7	-0.6	-0.8	-0.6	-0.4	-0.4	-0.7	0.0
Seeking ratio, punishment vs. effort	0.3	0.4	3.2	-0.7	-0.4	-0.3	0.1	-0.3	-0.3	-0.4	0.1	-0.2	-0.5	1.8
Retroperitoneal fat weight	4.2	13.8	20.4	-4.5	-4.3	-4.3	4.2	3.6	3.6	3.6	3.6	3.6	3.4	0.2
Reaction time number correct	0.8	1.2	1.5	1.0	1.1	1.1	-1.1	-1.2	-1.2	-1.2	-0.9	-1.0	-1.2	0.9
Reaction time mean minus median	1.8	2.3	3.9	2.0	1.8	1.8	-1.5	-1.5	-1.5	-1.5	-1.9	-1.5	-0.6	-0.5
Reaction time mean minus median AUC	1.8	2.4	3.3	1.7	1.7	1.7	-1.5	-1.6	-1.6	-1.6	-1.8	-1.5	-1.2	0.3
Reaction time num false alarms	0.2	0.2	1.3	-0.2	0.0	0.0	0.0	-0.4	-0.4	-0.1	0.2	-0.2	-1.1	0.8
Reaction time num false alarms AUC	0.4	0.6	2.1	0.5	0.6	0.6	-0.5	-0.8	-0.8	-0.6	-0.2	-0.8	-1.5	0.6
Reaction time trials correct on left	0.8	1.2	1.5	1.0	1.1	1.1	-1.1	-1.2	-1.2	-1.2	-0.9	-1.0	-1.2	0.9
Reaction time trials on left	1.0	1.5	1.9	1.1	1.2	1.2	-1.2	-1.4	-1.4	-1.3	-1.0	-1.1	-1.4	1.0
Reaction time mean	0.1	0.1	0.3	0.2	0.2	0.1	-0.1	-0.1	-0.1	-0.1	-0.5	-0.6	0.4	0.1
Reaction time mean AUC	0.0	0.1	0.3	0.1	0.0	0.0	0.1	-0.0	-0.0	0.0	-0.4	-0.4	0.6	0.0
Median of all reaction times	0.1	0.1	0.5	-0.3	-0.4	-0.4	0.4	0.3	0.3	0.3	0.0	-0.2	0.7	0.1
Reaction time omissions	1.3	1.7	2.2	1.5	1.5	1.4	-1.1	-1.5	-1.5	-1.3	-1.2	-1.5	-1.2	0.1
Reaction time false alarm rate	0.1	0.1	0.5	-0.3	-0.1	-0.1	0.2	-0.1	-0.1	0.1	0.4	-0.1	-0.7	0.4
Reaction time premature initiation rate	1.9	2.5	3.9	1.9	1.8	1.9	-2.0	-1.4	-1.4	-1.4	-1.6	-1.6	-1.6	0.1
Reaction time premature initiations	4.0	5.7	7.8	2.7	2.7	2.7	-2.8	-2.3	-2.3	-2.3	-2.3	-2.3	-2.4	0.6
Std. dev. reaction times	0.6	0.8	1.8	1.1	1.0	1.0	-0.8	-0.9	-0.9	-0.8	-1.3	-1.1	-0.2	-0.0
Reaction time trials completed	1.0	1.5	1.9	1.1	1.2	1.2	-1.2	-1.4	-1.4	-1.3	-1.0	-1.1	-1.4	1.0
Reaction time trials AUC	0.7	1.0	1.3	0.9	1.0	1.0	-1.0	-1.1	-1.1	-1.1	-0.8	-0.9	-1.2	0.9
Run reversals in cocaine runway, females	0.7	0.7	2.7	-0.1	-0.2	-0.3	0.4	0.9	0.9	0.9	1.2	0.8	0.1	-1.6
Run reversals in cocaine runway, males	1.3	1.2	4.1	0.3	0.6	0.6	-0.7	-1.1	-1.1	-1.2	-0.8	-1.2	-1.4	2.0
Latency to leave start box in cocaine runway	0.6	0.6	1.2	-0.5	-0.6	-0.7	0.8	0.7	0.7	0.8	0.8	0.7	1.1	-0.9
Latency to leave start box in cocaine runway, F	0.3	0.3	0.7	-0.3	-0.4	-0.4	0.6	0.5	0.5	0.5	0.6	0.5	0.6	-0.8
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.1	0.0	-0.0	0.0	0.1	-0.1	0.3	-0.0
Std. dev. time between licks in bursts	0.2	0.2	1.4	0.1	0.2	0.2	-0.3	-0.2	-0.2	-0.3	-0.0	-0.3	-1.2	0.7
Total sessions with >9 infusions	2.8	3.1	4.3	-1.7	-1.8	-1.8	1.8	1.9	1.8	2.0	2.1	1.8	1.5	-1.0
Short access day 1 total inactive lever presses	3.5	4.0	5.3	-2.3	-2.2	-2.2	2.1	2.2	2.2	2.1	1.8	1.8	1.8	-0.1
Short access day 10 total inactive lever presses	1.9	2.2	3.5	-1.9	-1.7	-1.7	1.7	1.3	1.3	1.2	1.6	1.5	1.1	0.7
Short access day 1 total infusions	6.4	6.8	8.9	-2.5	-2.6	-2.6	2.6	2.9	2.8	3.0	2.9	2.5	2.3	-1.5
Short access day 10 total infusions	6.3	7.0	8.8	-2.0	-2.4	-2.3	2.4	3.0	2.9	3.0	2.9	2.7	2.8	-2.7
Short access total infusions	4.1	4.6	6.5	-1.8	-2.0	-2.0	2.0	2.5	2.4	2.5	2.4	2.0	1.9	-1.8
Short access day 1 locomotion	4.9	5.2	6.9	-2.1	-2.2	-2.2	2.1	2.6	2.5	2.6	2.6	2.2	2.3	-1.5
Short access day 10 total locomotion	3.9	4.4	6.0	-1.8	-2.0	-2.0	2.0	2.1	2.1	2.3	2.4	2.2	2.2	-1.7
Short access total locomotion	3.9	4.1	5.7	-1.7	-1.9	-1.9	1.9	2.2	2.2	2.3	2.4	1.9	2.0	-1.6
One hour access (0.3 mA shock)	6.8	8.0	11.2	-3.3	-3.3	-3.2	3.1	2.9	2.8	2.8	2.7	2.7	2.8	0.4
Compulsive drug intake	2.6	2.6	4.2	1.9	1.8	1.9	-1.8	-1.5	-1.5	-1.6	-1.4	-1.4	-2.1	0.1
One hour access (shock baseline)	6.0	6.9	10.1	-3.2	-3.1	-3.1	2.9	2.6	2.5	2.5	2.3	2.3	3.0	0.5
Social response proportion	0.3	0.3	0.8	0.9	0.6	0.7	-0.7	-0.2	-0.2	-0.2	-0.8	-0.1	0.3	-0.8
Social responses	0.3	0.3	0.7	0.8	0.7	0.7	-0.8	-0.3	-0.3	-0.4	-0.8	-0.3	-0.6	-0.1
Social time	0.4	0.5	0.9	0.8	0.8	0.8	-1.0	-0.5	-0.5	-0.5	-0.9	-0.5	-0.9	0.0
Soleus weight	2.1	6.3	12.0	-3.5	-3.0	-3.1	3.0	2.0	2.0	1.7	2.6	2.3	2.1	1.4
Bone: stiffness	0.5	0.8	3.3	1.4	1.1	1.0	-0.9	-0.5	-0.5	-0.4	-0.6	-0.4	0.3	-1.8
Tibialis anterior weight	9.7	33.2	43.8	6.6	6.6	6.5	-6.1	-6.1	-6.1	-5.8	-5.5	-5.8	-5.3	0.6
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.6	0.4	0.2	0.2	-0.1	0.0	-0.0	0.0	0.1	0.0	0.1	-0.8
Time to tail flick, vehicle, after self-admin	0.3	0.3	2.2	0.7	0.5	0.5	-0.3	-0.1	-0.0	0.1	0.2	0.1	-0.6	-1.5
Time to tail flick, test, before self-admin	2.7	2.6	4.1	-1.3	-1.4	-1.4	1.5	1.7	1.7	1.7	2.0	2.0	1.2	-1.7
Time to tail flick, test, after self-admin	0.0	0.0	0.1	0.2	0.2	0.2	-0.3	-0.1	-0.0	-0.2	-0.3	-0.1	-0.1	0.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	1.0	0.4	0.3	0.3	-0.2	-0.0	0.0	0.1	0.1	0.2	-0.2	-1.0
Delta time to tail flick, test, before/after SA	4.6	4.1	6.1	1.8	1.9	1.9	-2.0	-2.0	-2.0	-2.1	-2.5	-2.3	-1.9	1.9
Tibia length	1.6	4.5	6.3	2.1	2.2	2.1	-1.9	-2.5	-2.5	-2.5	-2.5	-2.1	-1.4	1.0
Ambulatory time before self-admin	0.3	0.3	0.6	0.6	0.5	0.5	-0.4	-0.7	-0.7	-0.6	-0.8	-0.6	0.2	0.1
Ambulatory time after self-admin	0.3	0.3	1.5	-0.4	-0.5	-0.5	0.5	0.2	0.2	0.4	0.2	0.6	1.2	-0.4
Bone: tissue strength	0.1	0.1	0.2	0.0	-0.0	-0.1	0.0	0.1	0.1	0.1	-0.1	0.2	0.5	-0.4
Total heroin consumption	3.7	4.3	6.5	2.6	2.5	2.4	-2.3	-2.1	-2.1	-2.0	-2.0	-2.1	-1.7	-0.5
Bone: trabecular number	0.6	0.9	5.1	0.3	-0.2	-0.1	0.2	0.9	0.9	0.9	0.1	0.9	1.1	-2.3
Bone: trabecular spacing	0.1	0.1	0.6	-0.4	-0.3	-0.3	0.2	-0.0	-0.0	-0.0	0.4	-0.1	-0.0	0.7
Bone: trabecular thickness	1.5	1.8	2.4	-1.1	-1.3	-1.2	1.2	1.6	1.6	1.6	1.1	1.4	1.3	-1.5
Bone: trabecular tissue density	1.3	1.8	4.0	-2.0	-1.6	-1.7	1.7	0.8	0.8	0.6	1.2	1.1	1.0	1.4
Water consumed over 24 hours	0.4	0.5	1.0	1.0	0.8	0.9	-1.0	-0.4	-0.4	-0.4	-0.8	-0.5	-0.6	-0.4
Number of responses in last shaping day	0.5	0.5	0.9	-0.9	-0.9	-0.8	0.7	0.8	0.8	0.9	0.8	0.3	0.2	0.5