Hub : Genes

Pacs1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Pacs1 0.07 0.06 6.2e-03 0.02 0.03 0.01 0.02 3.1e-02 6.3e-03 9.8e-02 2.7e-02
2 IL gene expression Pacs1 0.22 0.12 1.5e-04 0.06 0.12 0.07 0.08 1.3e-02 9.7e-04 1.1e-02 6.6e-03
3 PL gene expression Pacs1 0.13 0.08 5.5e-14 0.12 0.13 0.12 0.12 7.0e-13 9.0e-14 3.2e-13 9.0e-13
4 NAcc gene expression Pacs1 0.16 0.1 4.7e-07 0.04 0.04 0.05 0.04 3.8e-06 6.8e-07 1.7e-07 8.4e-07
5 IC gene expression Pacs1 0.26 0.14 6.4e-09 0.14 0.17 0.13 0.14 1.9e-06 1.6e-07 4.4e-06 2.1e-06
6 OFC gene expression Pacs1 0.34 0.18 5.4e-05 0.14 0.11 0.07 0.05 3.7e-04 1.5e-03 8.8e-03 2.4e-02
7 Adipose gene expression Pacs1 0.2 0.08 2.6e-15 0.11 0.11 0.1 0.12 7.0e-12 1.5e-12 1.5e-11 9.1e-13
8 Brain gene expression Pacs1 0.12 0.06 1.9e-13 0.15 0.15 0.15 0.14 3.5e-14 1.7e-13 1.2e-13 2.1e-13
9 Adipose mRNA stability Pacs1 0.16 0.1 3.3e-04 0.02 0.02 0.01 0.01 2.8e-03 3.5e-03 6.0e-02 7.1e-03
10 IL mRNA stability Pacs1 0.23 0.13 2.7e-03 0.04 0.05 0.01 0.03 3.5e-02 2.1e-02 1.6e-01 6.6e-02
11 NAcc mRNA stability Pacs1 0.09 0.08 5.9e-04 0.02 0.01 0.02 0.01 8.0e-04 1.8e-03 5.5e-04 3.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.61.05.8-0.1-0.2-0.5-0.1-0.7-1.00.9-1.0-0.8-2.4-1.0
Area under the delay curve1.01.21.8-0.8-0.8-0.9-1.2-1.0-1.01.1-1.2-1.2-1.1-1.4
BMI with tail0.82.717.60.50.3-0.30.3-0.8-1.21.2-1.1-0.9-4.2-2.4
BMI without tail0.51.46.50.30.3-0.1-0.4-0.4-1.11.1-1.0-0.7-2.6-2.2
Body weight0.73.06.72.62.52.11.81.71.0-1.11.01.4-1.9-0.4
Weight adjusted by age1.52.23.31.71.71.61.81.61.4-1.51.51.50.41.1
Bone surface1.32.35.72.01.81.42.41.10.7-1.00.61.1-2.30.8
Bone volume0.40.84.70.80.70.31.50.1-0.1-0.1-0.20.4-2.20.4
Breakpoint value in progressive ratio session2.02.44.22.01.81.62.01.51.4-1.41.61.6-0.51.1
Number of licking bursts0.20.30.60.70.60.50.80.50.7-0.60.70.3-0.20.5
Context. condit. distance diff. score1.72.12.9-1.6-1.6-1.5-1.7-1.4-1.51.5-1.5-1.3-0.0-1.2
Locomotion velocity, session 10.10.10.40.10.20.3-0.30.30.1-0.10.20.60.6-0.2
Locomotion distance, session 10.50.62.4-0.1-0.1-0.3-0.5-0.4-0.80.6-0.7-0.3-1.6-1.3
Locomotion velocity, session 20.80.91.81.31.31.11.00.90.7-0.60.71.0-0.8-0.2
Locomotion distance, session 20.20.31.50.30.30.1-0.1-0.0-0.50.3-0.40.2-1.2-1.1
Locomotion velocity, session 30.60.71.3-0.7-0.8-0.8-0.9-0.9-0.70.8-0.7-0.7-0.9-1.2
Locomotion distance, session 30.00.00.0-0.1-0.1-0.1-0.2-0.10.1-0.1-0.00.1-0.1-0.1
Stereotopy head waving bouts, day 31.82.13.1-1.4-1.4-1.4-1.7-1.5-1.41.4-1.6-1.5-0.9-1.8
Stereotopy head waving duration, day 31.51.82.7-1.5-1.4-1.4-1.2-1.5-1.31.3-1.5-1.6-0.8-1.1
Locomotion velocity, session 71.61.82.9-1.0-1.1-1.3-1.0-1.3-1.51.5-1.4-1.3-1.4-1.7
Locomotion distance, session 70.50.72.4-0.4-0.4-0.5-1.0-0.5-0.80.8-0.9-0.8-0.7-1.6
Stereotopy head waving bouts, day 70.30.31.0-0.4-0.5-0.60.2-0.7-0.60.5-0.6-0.3-1.00.0
Stereotopy head waving duration, day 70.20.21.70.40.20.10.8-0.10.1-0.10.00.1-1.30.2
Locomotion velocity, session 80.70.91.51.11.21.20.41.20.9-1.10.71.00.40.3
Locomotion distance, session 80.71.01.6-0.9-0.9-1.0-0.8-1.0-1.21.1-1.0-0.7-0.7-1.1
Degree of sensitization distance0.60.61.6-0.4-0.4-0.5-0.7-0.5-1.00.9-0.9-0.9-0.9-1.3
Degree of sensitization stereotypy0.30.31.20.60.40.21.10.20.2-0.30.30.6-0.70.6
Conditioned locomotion1.01.22.21.41.51.40.91.40.9-0.90.91.20.40.4
Cocaine response after cond. corrected1.01.22.9-1.2-1.1-1.0-1.7-0.9-1.11.1-1.0-0.80.3-1.2
Cocaine response after cond. not corrected0.70.81.9-1.0-1.0-0.9-1.4-0.8-0.90.9-0.7-0.70.1-0.9
Cocaine response before conditioning0.70.92.20.90.80.71.50.71.0-0.91.10.7-0.31.1
Saline control response1.72.24.32.02.11.91.31.71.0-1.41.21.6-0.50.5
Bone: connectivity density0.50.85.60.90.90.60.80.2-0.30.1-0.4-0.2-2.4-0.5
Bone: cortical apparent density0.30.40.60.60.60.60.30.70.8-0.80.70.60.70.4
Bone: cortical area0.91.42.21.31.21.21.41.21.2-1.21.21.50.31.0
Bone: cortical porosity0.10.20.8-0.1-0.1-0.2-0.2-0.3-0.30.3-0.1-0.5-0.9-0.5
Bone: cortical porosity0.10.10.70.20.30.20.10.0-0.10.00.2-0.2-0.8-0.4
Bone: cortical thickness4.27.09.03.03.03.01.93.02.9-2.73.02.91.61.4
Bone: cortical thickness1.31.52.71.21.41.40.31.51.6-1.41.31.11.10.2
Bone: cortical tissue density0.40.60.80.80.80.80.40.80.9-0.90.80.80.70.5
Condit. Reinf. active minus inactive responses0.10.10.40.30.20.1-0.00.0-0.50.3-0.00.6-0.7-0.6
Condit. Reinf. active-inactive response ratio0.10.10.30.10.0-0.0-0.1-0.0-0.50.4-0.00.4-0.4-0.4
Condit. Reinf. active responses0.10.10.40.10.0-0.10.2-0.1-0.60.5-0.20.5-0.6-0.5
Condit. Reinf. inactive responses0.10.20.3-0.3-0.4-0.40.2-0.4-0.60.5-0.6-0.3-0.5-0.3
Incentive salience index mean0.20.20.90.30.2-0.00.0-0.1-0.60.5-0.30.5-1.0-0.9
Condit. Reinf. lever presses0.20.20.90.70.50.40.80.3-0.0-0.00.10.9-0.5-0.1
Condit. Reinf. active minus inactive responses0.20.20.6-0.3-0.5-0.50.5-0.6-0.50.3-0.4-0.5-0.80.6
Condit. Reinf. active-inactive response ratio0.50.61.0-0.8-1.0-1.00.4-1.0-0.70.7-0.7-0.6-0.50.6
Condit. Reinf. active responses0.20.32.0-0.1-0.2-0.30.4-0.5-0.50.3-0.3-0.9-1.40.1
Condit. Reinf. inactive responses0.30.31.90.20.20.1-0.3-0.1-0.20.2-0.1-0.9-1.4-0.8
Condit. Reinf. lever presses1.01.43.61.51.31.11.91.01.0-1.01.00.6-0.91.1
Condit. Reinf. lever reinforcers received0.20.31.70.20.10.00.7-0.2-0.1-0.0-0.0-0.6-1.30.4
Conditioned reinforcement - actives0.61.03.90.40.40.41.80.50.8-0.90.80.60.62.0
Conditioned reinforcement - inactives0.81.22.3-1.5-1.5-1.40.5-1.2-0.80.7-1.0-0.90.41.3
Conditioned locomotion2.63.47.2-2.7-2.6-2.4-1.2-2.1-1.61.5-1.7-1.71.00.3
Patch foraging indifference point 0 sec0.10.20.4-0.4-0.4-0.4-0.2-0.5-0.40.4-0.4-0.7-0.5-0.2
Patch foraging indifference point AUC2.23.14.72.01.91.92.21.81.6-1.91.61.90.31.7
Delay disc. indifference point, 0s delay2.72.94.6-1.5-1.4-1.5-2.1-1.5-1.71.8-1.8-1.8-1.1-2.1
Delay disc. indifference point, 16s delay0.91.01.4-1.1-1.1-1.2-0.6-1.2-1.01.0-1.2-1.1-0.8-0.4
Delay disc. indifference point, 2s delay0.40.40.6-0.7-0.7-0.7-0.6-0.8-0.60.7-0.5-0.7-0.6-0.5
Delay disc. indifference point, 24s delay0.10.10.6-0.2-0.1-0.0-0.80.0-0.10.2-0.2-0.10.4-0.6
Delay disc. indifference point, 4s delay1.21.32.4-0.9-0.8-0.9-1.5-0.9-1.11.1-1.2-1.3-0.8-1.5
Delay disc. indifference point, 8s delay0.80.91.9-0.7-0.6-0.6-1.4-0.7-0.80.9-1.2-1.0-0.7-1.4
Indifference point function ln k4.27.413.5-3.3-3.2-3.0-3.7-2.7-2.42.8-2.2-2.20.6-2.5
Indifference point function log k4.27.413.5-3.3-3.2-3.0-3.7-2.7-2.42.8-2.2-2.20.6-2.5
Patch foraging total patch changes 0 sec0.00.00.1-0.1-0.0-0.0-0.2-0.1-0.00.0-0.0-0.20.1-0.1
Patch foraging total patch changes 12 sec1.92.44.82.22.11.91.71.71.3-1.51.31.3-0.80.6
Patch foraging total patch changes 18 sec0.20.30.60.70.60.50.80.40.3-0.40.40.2-0.70.3
Patch foraging total patch changes 24 sec1.42.33.31.81.81.81.51.71.4-1.61.51.40.41.2
Patch foraging total patch changes 6 sec0.30.51.21.11.11.00.20.80.5-0.60.50.5-0.7-0.3
Patch foraging time to switch 0 sec0.40.85.40.70.60.21.3-0.0-0.20.3-0.2-0.2-2.3-0.4
Patch foraging water rate 0 sec0.61.36.2-1.5-1.4-1.0-1.5-0.6-0.50.4-0.4-0.32.50.3
Patch foraging water rate 12 sec2.04.211.1-2.8-2.5-2.0-3.3-1.5-1.41.3-1.3-1.52.6-0.9
Patch foraging water rate 18 sec1.21.96.0-1.7-1.5-1.3-2.5-1.1-1.01.0-0.9-1.11.2-1.2
Patch foraging water rate 24 sec1.21.74.3-1.8-1.6-1.2-2.0-0.9-0.80.9-0.9-0.52.1-0.3
Patch foraging water rate 6 sec1.31.86.7-1.6-1.4-1.0-2.6-0.7-0.70.6-0.7-0.42.2-0.8
Seeking ratio, delayed vs. immediate footshock0.60.81.3-0.7-0.7-0.8-0.3-0.9-1.00.9-1.0-1.1-1.2-0.8
Distance traveled before self-admin0.20.20.90.40.30.21.00.00.1-0.20.20.0-0.90.4
Distance traveled after self-admin0.20.31.10.50.40.41.00.30.4-0.50.20.3-0.20.9
Extensor digitorum longus weight3.915.428.25.35.14.74.04.43.7-3.53.64.1-0.41.2
Bone: elastic displacement0.50.53.7-0.10.10.3-1.00.60.3-0.40.40.61.9-0.0
Bone: elastic work1.31.72.81.51.61.70.11.71.2-1.21.31.61.2-0.0
Bone: endosteal estimation1.94.16.2-2.0-2.1-2.2-1.2-2.3-2.52.3-2.5-1.7-1.7-1.4
Bone: endosteal perimeter2.24.66.4-2.1-2.3-2.5-0.9-2.5-2.52.4-2.5-1.9-2.0-0.9
Epididymis fat weight1.75.710.8-3.2-3.3-3.1-1.7-2.8-2.42.4-2.2-2.20.4-0.3
Delta time in closed arm before/after self-admin0.30.31.20.30.50.5-0.90.5-0.00.00.10.20.2-1.1
Delta time in open arm before/after self-admin0.70.72.30.60.50.51.50.50.9-0.90.60.70.11.4
Diff in mean of infusions in LGA sessions0.70.91.21.11.11.01.01.00.8-0.91.01.10.30.8
Delay discount exponential model param0.70.81.30.70.60.71.00.70.8-0.81.01.00.91.1
Extinction: sum of active levers before priming0.80.92.01.31.20.91.40.70.5-0.60.70.7-1.20.2
Active lever presses in extinction session 63.23.25.62.01.81.72.41.71.7-1.71.91.80.11.7
Bone: final force1.11.83.21.81.71.51.81.41.1-1.20.81.4-0.40.8
Bone: final moment1.01.62.81.71.61.41.61.31.0-1.10.81.3-0.40.7
Food consumed during 24 hour testing period0.60.92.50.60.50.61.10.71.0-1.00.90.90.91.6
Glucose4.36.88.1-2.7-2.8-2.8-2.4-2.8-2.82.8-2.8-2.6-1.8-2.3
Heart weight4.77.211.3-2.3-2.2-2.4-3.2-2.5-2.92.7-2.8-2.8-2.1-3.4
Delay discount hyperbolic model param0.70.81.30.70.70.71.00.80.9-0.91.01.11.01.1
Intermittent access intake day 1-15 change0.20.41.4-0.8-0.8-0.60.6-0.5-0.30.2-0.4-0.10.91.2
Intermittent access intake escalation0.20.42.1-0.5-0.6-0.40.9-0.3-0.1-0.0-0.10.31.01.5
Intermittent access intake escalation 20.30.41.7-0.6-0.6-0.50.7-0.3-0.10.0-0.10.31.01.3
Intermitt. access day 1 inactive lever presses0.00.00.2-0.2-0.2-0.20.2-0.2-0.10.1-0.10.10.20.4
Intermitt. access day 15 inactive lever presses0.51.01.8-1.2-1.3-1.30.3-1.2-1.00.9-1.0-1.0-0.30.5
Intermitt. access escalation Index3.24.56.7-2.4-2.3-2.2-2.6-2.1-2.22.2-2.2-2.2-0.4-1.9
Intermittent access day 1 total infusions4.06.48.8-2.6-2.6-2.7-1.5-2.8-2.82.8-2.9-3.0-2.1-1.6
Intermittent access day 15 total infusions2.33.56.2-2.4-2.5-2.4-0.5-2.2-2.01.9-2.1-1.9-0.30.3
Intermittent access terminal intake (last 3 days)2.83.76.0-2.4-2.5-2.4-0.5-2.3-2.12.0-2.2-2.1-0.80.1
Intermittent access total infusions3.54.15.6-2.3-2.3-2.4-0.9-2.3-2.32.2-2.3-2.3-1.3-0.6
Intermittent access day 1 locomotion3.13.95.6-2.1-2.1-2.2-1.2-2.2-2.12.1-2.2-2.4-1.6-1.2
Intermittent access day 15 total locomotion1.83.35.6-2.3-2.4-2.30.0-2.2-1.91.8-2.0-1.9-0.70.5
Intermittent access total locomotion5.66.710.2-3.1-3.2-3.2-0.7-3.1-2.82.8-2.9-2.8-1.4-0.3
Intermittent access standard deviation0.20.40.9-1.0-0.9-0.8-0.3-0.6-0.60.5-0.6-0.60.70.5
Left kidney weight0.62.94.5-2.1-2.1-2.1-1.0-2.0-2.12.0-1.9-1.2-0.1-0.9
Right kidney weight0.10.51.2-1.1-1.1-1.0-0.5-0.8-0.50.6-0.5-0.30.80.0
Cocaine induced anxiety0.10.10.90.30.20.20.90.10.3-0.30.20.1-0.10.7
Post-drug Anxiety0.80.91.91.00.90.91.40.81.1-1.10.80.7-0.01.1
Baseline Anxiety0.30.40.70.60.70.7-0.20.70.8-0.80.60.60.40.0
Tail length0.52.13.51.61.71.80.71.91.3-1.41.11.61.40.6
Length with tail1.56.710.43.23.23.21.83.12.5-2.62.42.91.21.2
Length without tail1.96.08.62.92.92.91.52.82.8-2.62.62.61.01.1
Times rat made contact with spout0.10.10.40.40.40.30.10.3-0.10.0-0.20.2-0.6-0.3
Lifetime Intake2.93.54.7-2.0-2.0-2.1-1.1-2.0-2.12.1-2.1-2.2-1.3-0.9
Liver weight, left0.40.71.5-1.0-0.9-0.7-1.2-0.6-1.00.8-0.6-0.30.9-0.7
Liver weight, right1.42.55.7-1.9-1.7-1.5-2.4-1.4-1.51.6-1.2-1.30.5-1.6
Locomotor activity0.60.93.6-1.2-0.9-0.7-1.9-0.4-0.40.5-0.2-0.61.5-0.7
Locomotor testing distance0.81.56.0-1.4-1.1-0.8-2.5-0.6-0.70.7-0.5-0.81.6-1.0
Locomotor testing rearing1.22.36.5-1.9-1.6-1.3-2.6-1.2-1.51.3-1.3-1.50.5-1.2
Locomotion in novel chamber2.63.36.3-2.5-2.5-2.3-1.3-2.1-1.71.8-1.8-1.80.3-0.2
Locomotion in novel chamber post-restriction1.22.03.7-1.9-1.9-1.8-1.1-1.7-1.41.4-1.3-1.40.1-0.3
Fecal boli incidents, locomotor time 10.40.52.50.30.20.21.50.20.4-0.50.70.30.21.6
Change in fecal boli incidents, locomotor task0.50.51.7-0.4-0.3-0.4-1.1-0.4-0.40.6-0.7-0.6-0.6-1.3
Time >=10cm from walls, locomotor time 11.81.92.8-1.3-1.5-1.6-0.2-1.7-1.51.4-1.5-1.6-1.6-0.6
Bouts of movement, locomotor time 11.61.83.21.51.41.31.81.31.4-1.51.11.30.21.6
Total resting periods, locomotor time 11.01.22.51.21.11.01.60.91.0-1.20.90.9-0.01.4
Rest time, locomotor task time 10.40.51.1-1.0-1.0-0.9-0.5-0.7-0.50.5-0.4-0.30.70.4
Distance moved, locomotor task time 10.40.61.8-0.2-0.2-0.4-0.7-0.5-0.70.7-0.7-0.6-1.3-1.3
Vertical activity count, locomotor time 10.20.50.9-0.9-0.9-0.8-0.7-0.7-0.70.8-0.7-0.80.0-0.6
Time >=10cm from walls, locomotor time 20.00.00.20.1-0.0-0.10.5-0.10.1-0.10.10.3-0.20.3
Bouts of movement, locomotor time 20.20.30.70.70.70.60.90.50.7-0.60.30.3-0.40.5
Total resting periods, locomotor time 20.10.10.30.30.30.20.60.20.4-0.2-0.10.0-0.50.3
Rest time, locomotor task time 21.41.82.9-1.7-1.7-1.6-1.4-1.4-1.21.4-1.3-1.10.2-0.7
Distance moved, locomotor task time 20.91.11.81.31.31.20.71.21.1-1.11.11.30.10.3
Vertical activity count, locomotor time 20.81.12.40.70.81.00.41.11.2-1.11.21.21.50.7
Light reinforcement 10.00.00.1-0.3-0.2-0.2-0.4-0.1-0.0-0.1-0.0-0.20.3-0.1
Light reinforcement 20.20.30.7-0.7-0.8-0.70.4-0.6-0.0-0.0-0.2-0.20.40.9
Bone: marrow area2.14.66.8-2.1-2.2-2.3-1.4-2.4-2.62.4-2.6-1.9-1.8-1.5
Bone: maximum diameter0.30.51.90.60.40.41.40.40.5-0.70.60.70.11.3
Bone: maximum force0.91.63.71.81.61.31.91.00.7-0.80.61.3-1.60.4
Bone: maximum moment0.81.43.01.71.51.21.70.90.6-0.70.61.2-1.50.3
Mean time between licks in bursts0.10.30.50.50.60.7-0.50.60.7-0.60.60.10.3-0.4
Mean num. licks in bursts0.40.61.1-0.7-0.6-0.6-0.8-0.6-1.00.9-1.1-0.4-0.2-0.8
Cd content in liver0.70.71.3-1.1-1.1-1.10.4-1.0-0.70.5-0.8-1.1-0.10.8
Co content in liver0.40.53.6-0.6-0.4-0.1-1.20.10.1-0.10.1-0.01.9-0.2
Cu content in liver0.20.20.5-0.3-0.3-0.4-0.3-0.5-0.30.5-0.3-0.4-0.7-0.7
Fe content in liver0.30.40.60.60.70.80.20.80.6-0.60.60.80.60.4
K content in liver0.20.20.70.30.30.1-0.30.0-0.40.3-0.2-0.2-0.8-0.9
Mg content in liver1.11.11.9-0.9-0.9-0.9-1.4-0.9-1.11.1-0.9-1.1-0.7-1.3
Mn content in liver2.52.84.62.12.01.82.01.71.5-1.71.61.5-0.21.3
Na content in liver1.21.32.41.11.01.10.71.11.3-1.21.41.51.00.9
Rb content in liver2.32.74.2-1.8-1.7-1.6-2.1-1.6-1.71.7-1.8-1.7-0.6-1.5
Se content in liver0.10.10.3-0.3-0.3-0.30.3-0.3-0.30.2-0.3-0.3-0.30.5
Sr content in liver3.32.93.41.81.81.81.81.81.7-1.81.81.80.81.4
Zn content in liver0.10.10.20.30.30.30.00.2-0.1-0.00.2-0.1-0.3-0.5
Bone: minimum diameter2.54.66.5-1.9-2.1-2.3-1.3-2.4-2.62.4-2.5-1.7-2.3-1.8
Time in familiar zone, hab. session 10.50.50.8-0.6-0.7-0.8-0.6-0.8-0.80.9-0.5-0.7-0.7-0.7
Time in novel zone, hab. session 10.20.20.9-0.10.00.2-0.60.20.5-0.50.00.10.90.1
Total zone transitions, hab. session 10.30.41.00.80.70.60.80.50.3-0.30.41.0-0.6-0.1
Total locomotion distance, hab. session 10.60.81.2-0.9-1.0-1.0-0.6-1.0-1.11.1-0.9-0.3-0.6-1.0
Locomotion velocity, hab. session 10.20.30.7-0.4-0.5-0.5-0.2-0.6-0.80.8-0.6-0.0-0.6-0.7
Time in familiar zone, hab. session 20.20.20.50.20.40.5-0.60.50.4-0.20.60.30.7-0.3
Time in novel zone, hab. session 20.30.31.0-0.3-0.3-0.40.1-0.5-0.50.3-0.8-0.5-1.0-0.2
Total zone transitions, hab. session 20.91.17.40.0-0.1-0.4-0.1-0.7-0.70.7-1.0-0.8-2.7-1.4
Total locomotion distance, hab. session 21.52.03.7-1.0-1.1-1.3-1.1-1.4-1.41.5-1.5-1.1-1.9-1.9
Locomotion velocity, hab. session 21.62.13.6-1.1-1.2-1.4-1.0-1.5-1.51.6-1.6-1.2-1.9-1.7
Novel to familiar place preference ratio0.60.62.70.90.70.51.60.40.4-0.60.50.4-0.71.1
Novelty place preference0.30.31.50.50.30.21.20.10.1-0.30.2-0.0-0.70.9
Time in novel zone, NPP test0.20.20.90.30.20.11.00.0-0.0-0.20.1-0.2-0.70.7
Total zone transitions, NPP test0.40.61.81.11.00.81.20.60.3-0.40.30.5-1.3-0.2
Total locomotion distance, NPP test0.30.51.2-0.3-0.4-0.5-0.4-0.6-0.90.8-0.8-0.2-0.9-1.1
Locomotion velocity, NPP test0.20.30.8-0.2-0.3-0.4-0.1-0.5-0.70.7-0.7-0.1-0.9-0.9
Intraocular pressure0.40.63.6-0.4-0.4-0.21.0-0.00.0-0.40.20.21.31.9
Delta distance traveled before/after self-admin0.10.10.50.00.10.2-0.30.30.2-0.3-0.00.20.70.1
Delta ambulatory time before/after self-admin0.10.10.50.20.30.4-0.10.40.3-0.40.10.30.70.2
Parametrial fat weight2.86.610.2-3.2-3.2-3.1-2.1-3.0-2.62.6-2.8-2.5-0.5-1.4
Pavlov. Cond. lever latency0.10.10.2-0.3-0.3-0.2-0.2-0.10.00.00.0-0.50.50.4
Pavlov. Cond. magazine entry latency0.20.31.9-0.1-0.2-0.40.2-0.6-0.40.6-0.5-0.0-1.4-0.5
Pavlov. Cond. change in total contacts0.10.20.60.2-0.1-0.20.7-0.30.00.20.20.6-0.80.1
Pavlov. Cond. index score0.10.10.60.40.30.20.50.10.4-0.20.30.8-0.30.1
Pavlov. Cond. latency score0.00.10.20.10.0-0.10.1-0.10.10.0-0.10.5-0.5-0.3
Pavlov. Cond. lever contacts0.10.10.50.0-0.0-0.1-0.2-0.2-0.20.2-0.20.3-0.5-0.7
Pavlov. Cond. magazine entry number0.40.51.2-0.7-0.5-0.4-1.0-0.4-0.80.6-0.7-1.10.0-0.7
Pavlov. Cond. intertrial magazine entries0.10.10.5-0.2-0.2-0.00.20.1-0.0-0.1-0.00.20.70.6
Pavlov. Cond. lever-magazine prob. diff.0.10.20.70.50.30.20.60.10.3-0.20.30.8-0.50.1
Pavlov. Cond. response bias0.20.31.00.60.40.40.80.30.6-0.40.61.0-0.00.4
Pavlov. Cond. lever latency0.71.02.3-1.0-0.9-0.9-1.5-0.9-1.01.0-1.0-0.9-0.1-1.2
Pavlov. Cond. magazine entry latency1.72.13.82.01.81.51.91.31.3-1.31.21.2-1.40.5
Pavlov. Cond. change in total contacts0.91.45.11.41.10.92.30.70.9-0.91.00.8-1.11.4
Pavlov. Cond. index score1.31.74.21.71.51.32.11.11.1-1.21.11.1-0.91.0
Pavlov. Cond. latency score1.21.64.11.61.41.22.01.01.1-1.11.11.1-0.81.0
Pavlov. Cond. lever contacts0.70.92.21.00.90.81.50.81.0-0.91.00.7-0.01.2
Pavlov. Cond. magazine entry number3.44.17.4-2.7-2.5-2.2-2.7-1.9-1.81.9-1.8-1.81.3-1.2
Pavlov. Cond. intertrial magazine entries0.40.61.2-1.1-1.1-1.0-0.5-0.9-0.70.7-0.6-0.80.40.1
Pavlov. Cond. lever-magazine prob. diff.1.62.14.81.81.71.42.21.21.2-1.31.21.2-1.01.1
Pavlov. Cond. response bias1.11.53.11.51.41.21.81.01.2-1.21.20.9-0.80.9
Time in closed arm before self-admin0.30.40.8-0.7-0.8-0.90.2-0.9-0.50.4-0.7-0.7-0.70.3
Time in closed arm after self-admin0.20.20.4-0.5-0.4-0.4-0.5-0.4-0.60.5-0.6-0.4-0.1-0.6
Time in open arm before self-admin0.91.05.0-0.5-0.2-0.1-2.2-0.1-0.80.9-0.2-0.30.5-2.0
Time in open arm after self-admin0.10.10.20.30.30.4-0.50.40.4-0.30.40.30.3-0.3
Bone: periosteal estimation0.10.20.6-0.3-0.4-0.50.3-0.6-0.70.5-0.60.0-0.7-0.0
Bone: periosteal perimeter0.10.21.00.1-0.1-0.30.4-0.4-0.40.3-0.4-0.0-1.00.1
Bone: post-yield work2.74.017.4-0.8-1.2-1.70.2-2.1-2.12.0-2.0-1.6-4.2-1.6
Progressive ratio test 1 active lever presses0.10.20.4-0.4-0.4-0.40.1-0.4-0.60.6-0.4-0.6-0.40.2
Progressive ratio test 1 breakpoint0.10.10.3-0.3-0.3-0.40.2-0.3-0.50.5-0.3-0.5-0.30.3
Progressive ratio test 1 inactive lever presses0.00.10.2-0.2-0.2-0.20.4-0.2-0.10.1-0.2-0.3-0.10.5
Progressive ratio test 2 active lever presses1.21.42.3-1.5-1.5-1.50.0-1.4-1.31.2-1.2-1.4-0.40.5
Progressive ratio test 2 breakpoint1.11.32.1-1.4-1.4-1.40.1-1.3-1.21.1-1.1-1.3-0.30.6
Progressive ratio test 2 inactive lever presses3.45.69.7-3.1-3.1-3.0-0.9-2.8-2.32.2-2.6-2.7-0.40.1
Incentive Sensitization - Responses0.20.30.9-0.3-0.3-0.50.6-0.5-0.60.5-0.4-0.6-0.90.2
Incentive Sensitization - Breakpoint0.30.30.7-0.4-0.5-0.60.4-0.6-0.70.6-0.5-0.7-0.90.1
Sum of active levers in priming session hrs 5-67.77.214.02.22.12.23.72.32.5-2.72.82.71.93.7
Progressive ratio0.81.26.2-0.1-0.2-0.50.0-0.8-1.00.9-1.1-1.1-2.5-1.3
Food seeking constrained by brief footshock0.10.10.20.40.40.40.10.40.2-0.20.20.50.1-0.1
Seeking ratio, punishment vs. effort0.30.53.8-0.4-0.30.0-1.00.20.3-0.20.30.51.90.1
Retroperitoneal fat weight6.025.841.2-6.4-6.3-5.8-5.5-5.5-5.05.0-5.0-4.90.3-3.0
Reaction time number correct0.50.91.70.90.91.00.51.01.1-0.91.31.11.00.7
Reaction time mean minus median1.33.37.52.11.91.72.71.61.7-1.71.71.7-0.51.6
Reaction time mean minus median AUC1.12.74.41.81.71.62.11.61.7-1.71.61.80.31.5
Reaction time num false alarms0.40.52.6-0.3-0.1-0.0-1.60.1-0.20.3-0.20.20.9-1.3
Reaction time num false alarms AUC0.30.41.50.30.40.5-1.20.50.3-0.10.20.60.7-1.2
Reaction time trials correct on left0.50.91.70.90.91.00.51.01.1-0.91.31.11.00.7
Reaction time trials on left0.61.22.01.01.11.10.61.21.2-1.01.41.31.10.8
Reaction time mean0.10.21.10.20.10.11.10.10.4-0.40.30.3-0.20.9
Reaction time mean AUC0.10.21.00.1-0.0-0.11.0-0.10.3-0.30.20.1-0.40.8
Median of all reaction times0.10.20.3-0.5-0.5-0.50.4-0.5-0.20.2-0.3-0.4-0.30.4
Reaction time omissions1.42.03.01.71.61.51.51.41.6-1.51.51.6-0.10.8
Reaction time false alarm rate0.40.52.2-0.4-0.3-0.2-1.5-0.2-0.40.5-0.6-0.10.3-1.5
Reaction time premature initiation rate1.42.03.61.71.91.80.01.71.3-1.61.61.30.3-0.3
Reaction time premature initiations2.54.57.02.52.62.60.72.52.2-2.32.52.30.90.4
Std. dev. reaction times0.71.33.31.21.11.01.80.91.2-1.21.01.1-0.31.3
Reaction time trials completed0.61.22.01.01.11.10.61.21.2-1.01.41.31.10.8
Reaction time trials AUC0.40.81.50.80.80.90.41.01.0-0.81.21.11.00.6
Run reversals in cocaine runway, females1.01.04.9-0.2-0.1-0.3-1.3-0.4-0.80.9-0.5-0.7-1.2-2.2
Run reversals in cocaine runway, males0.90.94.10.40.50.70.20.90.9-0.81.01.12.00.8
Latency to leave start box in cocaine runway0.70.81.7-0.6-0.8-0.9-0.4-1.0-0.91.0-0.9-0.9-1.3-0.7
Latency to leave start box in cocaine runway, F0.50.61.1-0.5-0.6-0.7-0.7-0.8-0.70.9-0.7-0.8-1.0-1.0
Latency to leave start box in cocaine runway, M0.10.10.20.10.0-0.00.5-0.1-0.10.10.0-0.0-0.50.2
Std. dev. time between licks in bursts0.20.31.10.10.30.4-1.10.40.5-0.30.4-0.10.9-0.8
Total sessions with >9 infusions0.60.71.8-0.5-0.5-0.6-0.3-0.7-1.00.9-0.8-1.0-1.3-0.8
Short access day 1 total inactive lever presses1.41.93.0-1.7-1.7-1.6-1.3-1.5-1.31.3-1.3-1.5-0.1-0.7
Short access day 10 total inactive lever presses0.10.30.8-0.6-0.5-0.5-0.9-0.4-0.60.6-0.5-0.40.1-0.6
Short access day 1 total infusions2.43.24.2-1.8-1.8-1.9-1.5-1.9-2.02.0-1.9-2.0-1.2-1.4
Short access day 10 total infusions2.73.46.2-1.4-1.5-1.7-0.7-1.8-2.22.2-2.0-2.1-2.5-1.4
Short access total infusions1.72.13.1-1.2-1.2-1.3-1.0-1.4-1.81.7-1.5-1.7-1.6-1.3
Short access day 1 locomotion1.51.92.8-1.5-1.5-1.5-0.9-1.5-1.61.6-1.4-1.7-0.9-0.8
Short access day 10 total locomotion1.01.92.9-1.4-1.5-1.6-0.5-1.6-1.71.6-1.5-1.6-1.2-0.7
Short access total locomotion1.82.23.1-1.6-1.6-1.7-0.8-1.6-1.81.7-1.5-1.7-1.1-0.8
One hour access (0.3 mA shock)3.84.47.1-2.7-2.6-2.5-1.8-2.2-2.12.1-2.3-2.3-0.1-0.6
Compulsive drug intake1.82.13.31.61.81.8-0.21.81.5-1.51.61.61.1-0.2
One hour access (shock baseline)3.35.18.7-2.9-3.0-2.8-1.0-2.6-2.32.3-2.4-2.5-0.4-0.0
Social response proportion0.40.51.70.80.70.61.30.50.4-0.60.40.1-0.51.0
Social responses0.30.40.50.70.70.70.60.70.5-0.60.60.50.30.7
Social time0.40.60.80.80.80.90.50.90.8-0.90.90.60.50.6
Soleus weight2.16.310.9-3.3-3.2-2.9-2.6-2.6-2.52.5-2.5-2.11.0-1.3
Bone: stiffness0.61.03.11.31.10.81.70.50.5-0.50.30.6-1.80.5
Tibialis anterior weight8.629.042.76.56.46.25.35.95.6-5.55.45.61.43.1
Time to tail flick, vehicle, before self-admin0.10.10.60.0-0.0-0.1-0.1-0.2-0.60.4-0.3-0.3-0.8-0.5
Time to tail flick, vehicle, after self-admin0.81.13.4-0.2-0.2-0.5-0.9-0.6-1.01.1-1.1-0.8-1.7-1.9
Time to tail flick, test, before self-admin4.54.65.7-2.0-2.0-2.0-2.4-2.0-2.42.4-2.3-2.2-1.4-2.3
Time to tail flick, test, after self-admin0.20.20.70.30.30.30.70.30.3-0.50.20.10.20.8
Delta time to tail flick, vehicle, before/after SA0.20.20.90.10.1-0.0-0.3-0.1-0.20.3-0.4-0.3-1.0-0.8
Delta time to tail flick, test, before/after SA6.46.68.72.32.32.42.72.52.8-2.92.72.62.13.0
Tibia length2.05.412.92.22.02.03.62.02.1-2.32.32.20.93.0
Ambulatory time before self-admin0.20.31.50.40.20.01.2-0.10.1-0.20.20.0-1.00.7
Ambulatory time after self-admin0.40.50.7-0.6-0.7-0.80.4-0.8-0.70.5-0.8-0.7-0.80.4
Bone: tissue strength0.10.10.2-0.1-0.1-0.20.0-0.2-0.30.3-0.2-0.2-0.5-0.1
Total heroin consumption2.93.45.72.42.32.12.01.91.8-1.81.91.9-0.31.2
Bone: trabecular number0.40.64.90.30.2-0.10.8-0.3-0.50.3-0.6-0.5-2.2-0.1
Bone: trabecular spacing0.20.31.1-0.6-0.5-0.4-1.1-0.3-0.30.4-0.2-0.40.7-0.7
Bone: trabecular thickness0.91.11.9-1.0-1.1-1.2-0.8-1.2-0.91.0-1.0-1.2-1.4-0.9
Bone: trabecular tissue density1.21.73.5-1.9-1.9-1.6-1.2-1.4-1.11.1-1.2-0.71.3-0.1
Water consumed over 24 hours0.50.71.21.01.11.00.71.00.7-0.80.60.8-0.10.5
Number of responses in last shaping day0.10.10.30.00.10.2-0.60.20.2-0.10.2-0.10.4-0.1