Hub : Genes

Krt1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Krt1	0.03	0.02	5.7e-05	0.04	0.03	0.04	0.04	2.1e-05	1.1e-04	5.8e-05	7.7e-05
2	BLA	gene expression	Krt1	0.13	0.04	8.6e-13	0.23	0.25	0.23	0.25	1.8e-12	1.5e-13	9.5e-13	1.4e-13
3	pVTA	gene expression	Krt1	0.17	0.09	1.5e-07	0.18	0.18	0.2	0.2	4.2e-08	2.5e-08	5.1e-09	3.7e-09
4	NAcc	gene expression	Krt1	0.1	0.02	0.0e+00	0.29	0.28	0.28	0.28	9.6e-34	3.6e-33	6.5e-33	6.3e-33
5	PL	gene expression	Krt1	0.11	0.05	4.8e-15	0.14	0.14	0.14	0.14	1.3e-15	2.2e-15	2.9e-15	3.2e-15
6	IL	gene expression	Krt1	0.13	0.09	6.2e-03	0.09	0.03	0.01	0.04	3.1e-03	7.6e-02	1.4e-01	5.1e-02
7	Brain	gene expression	Krt1	0.12	0.06	1.7e-12	0.14	0.14	0.14	0.14	2.3e-13	3.5e-13	1.4e-12	3.1e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	0.0	0.1	0.1	-0.1	0.3	0.3	-0.1	-0.1	-0.2	-0.3
Area under the delay curve	0.3	0.3	0.9	-0.5	0.5	0.5	-0.5	-0.3	-0.9	-0.6
BMI with tail	2.2	7.0	8.4	-1.7	2.8	2.8	-2.7	-2.7	-2.8	-2.9
BMI without tail	0.2	0.4	0.7	-0.3	0.5	0.8	-0.4	-0.4	-0.8	-0.8
Body weight	0.5	2.1	2.9	-0.3	1.6	1.7	-1.4	-1.5	-1.6	-1.7
Weight adjusted by age	0.6	0.7	1.1	0.6	0.8	1.1	-0.8	-0.7	-0.8	-0.8
Bone surface	0.2	0.4	0.6	-0.7	0.6	0.6	-0.6	-0.6	-0.5	-0.6
Bone volume	0.3	0.5	0.6	-0.8	0.7	0.8	-0.5	-0.5	-0.6	-0.8
Breakpoint value in progressive ratio session	0.3	0.3	2.1	-1.4	0.0	0.3	-0.1	-0.0	0.1	0.1
Number of licking bursts	0.1	0.1	0.5	-0.7	0.2	0.1	-0.2	-0.2	-0.2	-0.2
Context. condit. distance diff. score	0.2	0.2	0.4	-0.5	-0.5	-0.4	0.7	0.7	0.2	0.2
Locomotion velocity, session 1	5.3	5.7	6.2	2.3	-2.5	-2.3	2.5	2.5	2.3	2.3
Locomotion distance, session 1	0.9	1.1	2.1	1.4	-1.1	-0.9	1.1	1.1	0.9	0.9
Locomotion velocity, session 2	2.9	3.4	5.5	2.4	-1.8	-1.7	1.7	1.7	1.8	1.8
Locomotion distance, session 2	1.0	1.5	1.9	1.4	-1.2	-1.1	1.2	1.2	1.1	1.1
Locomotion velocity, session 3	5.7	6.7	7.2	2.5	-2.6	-2.7	2.5	2.5	2.7	2.6
Locomotion distance, session 3	5.5	6.0	6.5	2.2	-2.4	-2.5	2.4	2.4	2.6	2.5
Stereotopy head waving bouts, day 3	1.7	2.0	2.4	-1.6	1.4	1.4	-1.4	-1.4	-1.4	-1.4
Stereotopy head waving duration, day 3	0.0	0.0	0.1	-0.3	0.1	0.2	-0.1	-0.1	-0.2	-0.1
Locomotion velocity, session 7	1.1	1.2	1.4	0.2	-1.2	-1.1	1.2	1.2	1.2	1.2
Locomotion distance, session 7	3.3	4.2	4.9	1.7	-2.1	-2.0	2.0	2.0	2.2	2.2
Stereotopy head waving bouts, day 7	3.1	3.5	3.8	-1.7	1.9	1.9	-1.9	-1.9	-2.0	-2.0
Stereotopy head waving duration, day 7	2.6	3.2	3.7	-1.9	1.8	1.7	-1.8	-1.8	-1.8	-1.8
Locomotion velocity, session 8	0.3	0.4	0.5	0.2	-0.7	-0.5	0.7	0.7	0.5	0.5
Locomotion distance, session 8	1.9	2.8	3.3	1.4	-1.8	-1.7	1.8	1.8	1.6	1.6
Degree of sensitization distance	0.6	0.6	0.8	-0.9	0.7	0.9	-0.7	-0.7	-0.8	-0.8
Degree of sensitization stereotypy	2.7	3.0	3.1	-1.8	1.8	1.6	-1.8	-1.8	-1.7	-1.7
Conditioned locomotion	0.7	0.9	1.7	0.9	-1.1	-0.5	1.3	1.3	0.4	0.5
Cocaine response after cond. corrected	0.1	0.1	0.3	0.1	0.3	0.5	-0.2	-0.2	-0.6	-0.5
Cocaine response after cond. not corrected	0.0	0.0	0.1	0.3	0.1	0.2	-0.0	-0.0	-0.2	-0.2
Cocaine response before conditioning	1.2	1.4	2.3	0.6	-1.1	-1.3	1.1	1.1	1.5	1.3
Saline control response	0.1	0.1	0.3	-0.2	-0.4	-0.2	0.6	0.6	0.3	0.2
Bone: connectivity density	0.1	0.2	0.2	0.4	-0.4	-0.4	0.4	0.4	0.5	0.4
Bone: cortical apparent density	1.4	1.8	2.6	-0.9	1.3	1.6	-1.2	-1.2	-1.4	-1.6
Bone: cortical area	0.6	0.9	1.1	-0.7	1.1	0.9	-1.0	-1.0	-0.9	-0.9
Bone: cortical porosity	2.1	2.3	2.9	1.2	-1.6	-1.4	1.7	1.7	1.3	1.5
Bone: cortical porosity	1.8	2.0	2.5	1.2	-1.5	-1.4	1.6	1.6	1.2	1.4
Bone: cortical thickness	0.2	0.3	0.5	-0.2	0.7	0.6	-0.7	-0.7	-0.6	-0.6
Bone: cortical thickness	0.5	0.6	2.6	1.6	-0.4	-0.6	0.4	0.4	0.6	0.5
Bone: cortical tissue density	1.1	1.5	2.3	-0.8	1.1	1.5	-1.1	-1.1	-1.3	-1.5
Condit. Reinf. active minus inactive responses	0.4	0.4	0.5	0.7	-0.7	-0.6	0.7	0.7	0.5	0.6
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.6	0.7	-0.6	-0.7	0.6	0.6	0.7	0.7
Condit. Reinf. active responses	0.9	1.1	1.6	1.3	-1.1	-0.9	1.1	1.1	0.8	1.0
Condit. Reinf. inactive responses	0.9	1.1	1.8	1.4	-1.1	-0.8	1.2	1.2	0.8	0.8
Incentive salience index mean	0.0	0.0	0.1	0.3	-0.2	-0.2	0.1	0.1	0.1	0.2
Condit. Reinf. lever presses	0.6	0.7	0.9	-0.6	0.9	0.8	-0.9	-0.9	-1.0	-0.8
Condit. Reinf. active minus inactive responses	1.3	1.6	1.8	-1.3	1.3	1.2	-1.3	-1.3	-1.2	-1.3
Condit. Reinf. active-inactive response ratio	0.5	0.6	0.7	-0.7	0.8	0.7	-0.7	-0.7	-0.8	-0.8
Condit. Reinf. active responses	1.3	1.8	2.9	-1.7	1.3	1.2	-1.3	-1.3	-1.2	-1.3
Condit. Reinf. inactive responses	0.1	0.2	0.5	-0.7	0.3	0.3	-0.4	-0.4	-0.2	-0.3
Condit. Reinf. lever presses	0.3	0.4	0.6	0.2	-0.7	-0.8	0.6	0.6	0.6	0.7
Condit. Reinf. lever reinforcers received	0.4	0.6	1.3	-1.1	0.7	0.6	-0.7	-0.7	-0.6	-0.7
Conditioned reinforcement - actives	0.5	0.5	1.3	-1.1	0.6	0.7	-0.6	-0.6	-0.7	-0.7
Conditioned reinforcement - inactives	0.0	0.0	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.0	0.0
Conditioned locomotion	0.1	0.1	0.5	-0.7	-0.2	-0.1	0.2	0.2	0.1	0.2
Patch foraging indifference point 0 sec	0.3	0.4	0.6	0.1	-0.8	-0.7	0.7	0.7	0.6	0.6
Patch foraging indifference point AUC	0.6	0.7	0.8	-0.7	0.8	0.8	-0.9	-0.9	-0.9	-0.9
Delay disc. indifference point, 0s delay	0.2	0.2	0.4	0.3	0.4	0.6	-0.3	-0.2	-0.7	-0.6
Delay disc. indifference point, 16s delay	0.3	0.3	0.8	-0.8	0.4	0.6	-0.3	-0.3	-0.9	-0.5
Delay disc. indifference point, 2s delay	6.1	6.7	7.6	-2.5	2.7	2.4	-2.8	-2.6	-2.6	-2.7
Delay disc. indifference point, 24s delay	0.2	0.2	0.5	-0.6	0.3	0.7	-0.3	-0.2	-0.4	-0.4
Delay disc. indifference point, 4s delay	0.2	0.2	0.7	-0.3	0.4	0.1	-0.4	-0.3	-0.8	-0.6
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.1	-0.4	-0.2	0.3	0.5	0.0	0.3
Indifference point function ln k	0.2	0.3	0.4	0.5	-0.5	-0.4	0.7	0.7	0.4	0.3
Indifference point function log k	0.2	0.3	0.4	0.5	-0.5	-0.4	0.7	0.7	0.4	0.3
Patch foraging total patch changes 0 sec	0.8	1.2	1.5	0.6	-1.2	-1.2	1.2	1.2	1.1	1.1
Patch foraging total patch changes 12 sec	0.1	0.1	0.1	-0.4	-0.4	-0.2	0.4	0.4	0.1	0.0
Patch foraging total patch changes 18 sec	0.1	0.2	0.3	-0.3	-0.5	-0.4	0.3	0.3	0.6	0.5
Patch foraging total patch changes 24 sec	0.1	0.1	0.9	-0.9	-0.0	0.0	-0.1	-0.1	-0.0	-0.1
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	-0.4	-0.2	-0.1	0.1	0.1	-0.0	0.0
Patch foraging time to switch 0 sec	0.1	0.2	0.3	-0.3	0.5	0.5	-0.3	-0.4	-0.5	-0.5
Patch foraging water rate 0 sec	0.0	0.1	0.1	-0.1	-0.2	-0.3	0.0	0.0	0.4	0.3
Patch foraging water rate 12 sec	1.0	1.6	2.0	1.0	-1.3	-1.2	1.3	1.3	1.4	1.4
Patch foraging water rate 18 sec	0.0	0.0	0.1	-0.3	-0.2	-0.2	0.3	0.3	0.2	0.1
Patch foraging water rate 24 sec	0.1	0.2	0.6	-0.7	0.2	0.5	-0.2	-0.2	-0.3	-0.4
Patch foraging water rate 6 sec	0.4	0.5	1.0	0.2	-0.7	-0.7	0.7	0.7	1.0	0.7
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.2	-0.0	0.0	0.5	-0.0	-0.0	-0.1	-0.1
Distance traveled before self-admin	0.1	0.1	0.2	-0.4	0.2	-0.0	-0.2	-0.1	-0.4	-0.4
Distance traveled after self-admin	0.8	0.9	1.5	0.0	-1.0	-1.2	1.1	1.1	0.7	0.7
Extensor digitorum longus weight	7.0	27.5	30.8	-4.4	5.3	5.5	-5.2	-5.2	-5.5	-5.4
Bone: elastic displacement	6.3	7.2	9.0	2.2	-2.9	-2.6	3.0	3.0	2.4	2.5
Bone: elastic work	2.9	3.8	5.5	2.3	-1.9	-1.9	1.9	1.9	1.7	1.8
Bone: endosteal estimation	0.2	0.5	0.7	-0.8	0.7	0.7	-0.6	-0.6	-0.7	-0.7
Bone: endosteal perimeter	0.7	1.5	1.8	-1.1	1.3	1.3	-1.3	-1.3	-1.3	-1.2
Epididymis fat weight	3.1	7.2	11.6	3.4	-2.6	-2.5	2.6	2.6	2.5	2.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.7	-0.8	0.0	0.2	0.1	0.1	-0.3	-0.4
Delta time in open arm before/after self-admin	3.7	3.6	4.4	2.0	-1.8	-1.8	1.7	1.7	2.1	2.1
Diff in mean of infusions in LGA sessions	1.2	1.3	2.0	-0.1	1.2	1.4	-1.3	-1.3	-1.1	-1.1
Delay discount exponential model param	0.4	0.4	1.1	0.6	-0.6	-0.6	0.6	0.5	1.0	0.7
Extinction: sum of active levers before priming	0.8	0.8	1.0	-0.7	0.9	1.0	-1.0	-0.9	-0.8	-0.8
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.4	0.2	0.2	-0.2	-0.1	-0.3	-0.3
Bone: final force	0.2	0.3	0.5	-0.2	0.7	0.4	-0.7	-0.7	-0.4	-0.4
Bone: final moment	0.1	0.2	0.3	-0.2	0.6	0.3	-0.6	-0.6	-0.4	-0.4
Food consumed during 24 hour testing period	0.8	1.0	1.1	0.7	-1.0	-1.0	1.0	1.0	1.0	1.1
Glucose	0.1	0.2	0.6	0.8	-0.3	-0.2	0.2	0.2	0.4	0.4
Heart weight	0.1	0.1	0.2	-0.2	0.3	0.5	-0.3	-0.3	-0.2	-0.2
Delay discount hyperbolic model param	0.8	0.8	1.6	0.8	-0.9	-0.8	0.9	0.8	1.3	0.9
Intermittent access intake day 1-15 change	0.8	0.8	1.0	0.2	-0.9	-0.9	0.9	0.9	1.0	1.0
Intermittent access intake escalation	0.6	0.6	0.8	-0.2	-0.8	-0.8	0.8	0.8	0.9	0.9
Intermittent access intake escalation 2	0.4	0.4	0.4	-0.1	-0.6	-0.7	0.7	0.7	0.6	0.6
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.4	-0.6	0.4	0.2	-0.4	-0.4	-0.4	-0.2
Intermitt. access day 15 inactive lever presses	0.8	0.8	1.1	1.0	-0.9	-0.9	0.9	0.9	0.9	0.8
Intermitt. access escalation Index	1.7	1.5	3.6	-1.9	1.1	1.0	-1.2	-1.2	-1.0	-1.0
Intermittent access day 1 total infusions	0.1	0.2	0.6	-0.8	0.3	0.2	-0.3	-0.3	-0.2	-0.3
Intermittent access day 15 total infusions	0.2	0.2	0.2	-0.5	-0.4	-0.5	0.3	0.3	0.5	0.4
Intermittent access terminal intake (last 3 days)	0.3	0.3	2.0	-1.4	0.1	0.1	-0.1	-0.1	-0.1	-0.2
Intermittent access total infusions	0.4	0.4	2.5	-1.6	0.3	0.3	-0.3	-0.3	-0.3	-0.4
Intermittent access day 1 locomotion	0.2	0.3	0.3	-0.6	-0.5	-0.5	0.4	0.4	0.6	0.6
Intermittent access day 15 total locomotion	1.0	1.0	1.5	0.3	-1.1	-1.1	1.0	1.0	1.2	1.2
Intermittent access total locomotion	0.3	0.3	0.6	-0.8	-0.5	-0.6	0.4	0.4	0.6	0.5
Intermittent access standard deviation	0.5	0.6	0.9	0.9	-0.7	-0.8	0.7	0.7	0.7	0.7
Left kidney weight	0.1	0.4	0.6	-0.1	0.6	0.7	-0.6	-0.6	-0.8	-0.7
Right kidney weight	0.4	1.1	1.4	-0.5	1.2	1.0	-1.2	-1.2	-1.1	-1.1
Cocaine induced anxiety	0.2	0.2	0.2	-0.5	-0.4	-0.5	0.4	0.4	0.4	0.5
Post-drug Anxiety	0.4	0.5	1.9	-1.4	0.5	0.5	-0.5	-0.5	-0.5	-0.4
Baseline Anxiety	0.1	0.1	0.3	-0.0	0.4	0.5	-0.4	-0.4	-0.4	-0.4
Tail length	0.5	1.4	1.9	1.0	-1.3	-1.0	1.4	1.3	1.0	1.0
Length with tail	0.1	0.3	1.0	1.0	-0.5	-0.4	0.5	0.5	0.4	0.3
Length without tail	0.2	0.4	0.6	0.2	0.7	0.6	-0.7	-0.7	-0.5	-0.5
Times rat made contact with spout	0.7	0.8	1.1	0.5	-0.9	-1.0	0.9	0.9	0.9	1.0
Lifetime Intake	0.2	0.3	1.8	-1.3	-0.0	-0.0	0.0	0.0	0.0	-0.1
Liver weight, left	0.2	0.3	0.5	-0.0	-0.7	-0.6	0.7	0.7	0.6	0.4
Liver weight, right	0.2	0.3	0.5	-0.1	-0.6	-0.6	0.6	0.6	0.7	0.5
Locomotor activity	0.0	0.0	0.1	0.3	-0.2	-0.2	0.0	0.1	0.2	0.2
Locomotor testing distance	0.7	1.1	1.4	0.6	-1.2	-1.1	1.1	1.1	1.1	1.0
Locomotor testing rearing	0.3	0.5	0.6	0.6	-0.7	-0.6	0.8	0.8	0.8	0.6
Locomotion in novel chamber	2.3	2.9	3.5	-1.2	1.8	1.9	-1.8	-1.8	-1.7	-1.7
Locomotion in novel chamber post-restriction	0.9	1.1	2.2	-1.5	1.0	0.9	-1.1	-1.2	-0.8	-0.7
Fecal boli incidents, locomotor time 1	4.0	4.3	4.8	1.8	-2.2	-2.1	2.2	2.1	2.0	2.1
Change in fecal boli incidents, locomotor task	1.2	1.1	1.8	-1.0	1.0	1.3	-1.0	-1.0	-1.0	-0.9
Time >=10cm from walls, locomotor time 1	0.7	0.7	1.1	0.4	-0.9	-0.8	1.0	0.8	1.0	1.0
Bouts of movement, locomotor time 1	0.0	0.0	0.1	0.2	-0.0	-0.3	0.0	-0.2	0.3	0.3
Total resting periods, locomotor time 1	0.4	0.5	0.7	0.8	-0.6	-0.8	0.6	0.4	0.7	0.8
Rest time, locomotor task time 1	0.6	0.7	0.9	0.4	-0.9	-0.9	0.9	0.9	0.8	0.9
Distance moved, locomotor task time 1	1.1	1.2	1.6	-1.3	1.0	1.3	-1.0	-0.9	-1.0	-1.1
Vertical activity count, locomotor time 1	3.0	3.2	3.7	-1.7	1.9	1.9	-1.7	-1.8	-1.6	-1.9
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.7	-0.0	-0.4	-0.8	0.5	0.2	0.6	0.5
Bouts of movement, locomotor time 2	2.4	2.6	3.7	-1.7	1.8	1.3	-1.8	-1.9	-1.2	-1.4
Total resting periods, locomotor time 2	3.2	3.4	4.2	-1.9	2.0	1.6	-2.0	-2.1	-1.5	-1.7
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.1	-0.4	0.0	0.3	0.5	0.1	0.3
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.3	0.2	0.0	-0.2	-0.4	-0.1	-0.3
Vertical activity count, locomotor time 2	0.4	0.5	0.9	-0.2	0.8	0.4	-0.7	-1.0	-0.5	-0.8
Light reinforcement 1	0.1	0.2	0.3	-0.4	0.4	0.5	-0.5	-0.5	0.1	-0.2
Light reinforcement 2	0.0	0.1	0.1	0.4	0.1	0.2	-0.2	-0.2	0.3	0.2
Bone: marrow area	0.2	0.5	0.7	-0.8	0.7	0.7	-0.6	-0.6	-0.7	-0.6
Bone: maximum diameter	0.4	0.8	1.0	-1.0	1.0	0.9	-0.9	-0.9	-0.8	-0.8
Bone: maximum force	0.6	1.0	1.2	-0.7	1.1	0.9	-1.1	-1.1	-1.0	-0.9
Bone: maximum moment	0.4	0.8	0.9	-0.6	1.0	0.8	-0.9	-0.9	-0.9	-0.9
Mean time between licks in bursts	1.1	1.6	2.0	0.9	-1.3	-1.4	1.2	1.2	1.3	1.3
Mean num. licks in bursts	1.0	1.2	1.7	1.3	-1.1	-1.0	1.1	1.1	1.0	1.1
Cd content in liver	0.3	0.3	0.5	-0.0	-0.6	-0.7	0.6	0.6	0.5	0.5
Co content in liver	0.1	0.1	0.5	-0.7	-0.2	-0.1	0.1	0.2	0.2	0.1
Cu content in liver	0.7	0.8	5.1	-2.3	0.5	0.1	-0.5	-0.5	-0.2	-0.2
Fe content in liver	0.0	0.0	0.1	-0.2	-0.0	-0.0	-0.0	-0.0	0.4	0.1
K content in liver	0.2	0.2	0.3	0.1	-0.3	-0.6	0.2	0.2	0.6	0.5
Mg content in liver	0.4	0.4	0.7	-0.1	-0.6	-0.8	0.5	0.5	0.8	0.8
Mn content in liver	0.0	0.0	0.1	0.3	0.1	0.0	0.1	0.0	-0.1	-0.2
Na content in liver	0.1	0.1	0.3	-0.5	0.1	-0.1	-0.2	-0.2	-0.1	0.0
Rb content in liver	0.7	0.9	1.2	-1.0	-1.0	-0.8	1.1	1.1	0.7	0.7
Se content in liver	0.2	0.3	0.5	0.7	-0.5	-0.5	0.4	0.4	0.6	0.5
Sr content in liver	1.6	1.4	1.7	1.2	-1.2	-1.1	1.1	1.1	1.3	1.3
Zn content in liver	1.9	2.1	2.9	0.6	-1.5	-1.5	1.4	1.4	1.7	1.7
Bone: minimum diameter	0.7	1.3	1.6	-0.9	1.3	1.2	-1.2	-1.2	-1.3	-1.1
Time in familiar zone, hab. session 1	0.6	0.6	1.4	1.2	-0.7	-0.6	0.7	0.7	0.6	0.7
Time in novel zone, hab. session 1	2.2	2.2	3.5	-1.9	1.4	1.4	-1.4	-1.4	-1.3	-1.4
Total zone transitions, hab. session 1	0.4	0.6	0.7	-0.7	0.8	0.7	-0.8	-0.8	-0.7	-0.8
Total locomotion distance, hab. session 1	0.3	0.4	0.7	0.8	-0.5	-0.6	0.5	0.5	0.6	0.6
Locomotion velocity, hab. session 1	0.4	0.5	1.0	1.0	-0.7	-0.7	0.6	0.6	0.7	0.7
Time in familiar zone, hab. session 2	0.1	0.2	0.3	0.3	-0.3	-0.4	0.3	0.3	0.6	0.5
Time in novel zone, hab. session 2	0.6	0.6	0.9	-0.8	0.6	0.8	-0.6	-0.6	-1.0	-0.9
Total zone transitions, hab. session 2	0.2	0.2	0.4	0.6	-0.3	-0.5	0.2	0.2	0.5	0.6
Total locomotion distance, hab. session 2	0.3	0.4	1.4	1.2	-0.5	-0.6	0.5	0.5	0.5	0.6
Locomotion velocity, hab. session 2	0.5	0.7	2.1	1.4	-0.7	-0.8	0.6	0.6	0.7	0.8
Novel to familiar place preference ratio	0.9	0.9	1.4	-0.7	0.9	1.0	-0.9	-0.9	-1.2	-1.1
Novelty place preference	0.6	0.6	0.9	-0.6	0.7	0.8	-0.7	-0.7	-1.0	-0.9
Time in novel zone, NPP test	0.7	0.7	1.2	-0.8	0.8	0.9	-0.7	-0.7	-1.1	-1.0
Total zone transitions, NPP test	0.4	0.6	1.1	1.0	-0.7	-0.9	0.6	0.6	0.8	0.8
Total locomotion distance, NPP test	1.5	2.0	4.3	2.1	-1.2	-1.4	1.1	1.1	1.3	1.4
Locomotion velocity, NPP test	1.7	2.5	5.3	2.3	-1.3	-1.6	1.3	1.3	1.4	1.5
Intraocular pressure	0.9	1.3	2.3	-0.1	-1.2	-0.9	1.2	1.2	1.5	1.2
Delta distance traveled before/after self-admin	3.0	3.3	4.1	1.2	-1.9	-1.8	2.0	2.0	1.8	1.8
Delta ambulatory time before/after self-admin	3.1	3.4	4.6	1.2	-1.9	-1.9	2.1	2.1	1.8	1.8
Parametrial fat weight	4.0	7.7	9.4	2.3	-2.9	-3.1	3.0	3.0	2.4	2.6
Pavlov. Cond. lever latency	1.7	2.1	3.4	1.8	-1.4	-1.2	1.5	1.5	1.4	1.2
Pavlov. Cond. magazine entry latency	3.3	4.3	5.7	-2.4	2.1	1.9	-2.1	-2.1	-1.9	-1.9
Pavlov. Cond. change in total contacts	3.7	3.9	5.4	-2.3	2.0	1.8	-2.1	-2.1	-1.8	-1.6
Pavlov. Cond. index score	4.4	5.6	7.2	-2.7	2.4	2.1	-2.5	-2.5	-2.2	-2.1
Pavlov. Cond. latency score	4.0	5.1	7.2	-2.7	2.3	2.0	-2.3	-2.3	-2.1	-2.0
Pavlov. Cond. lever contacts	1.6	1.9	2.8	-1.7	1.4	1.1	-1.5	-1.5	-1.2	-1.0
Pavlov. Cond. magazine entry number	1.6	2.0	2.7	1.7	-1.5	-1.2	1.5	1.5	1.2	1.1
Pavlov. Cond. intertrial magazine entries	2.0	2.4	2.9	1.4	-1.7	-1.4	1.7	1.7	1.5	1.4
Pavlov. Cond. lever-magazine prob. diff.	4.4	5.5	7.0	-2.7	2.4	2.1	-2.5	-2.5	-2.2	-2.0
Pavlov. Cond. response bias	1.6	2.0	2.6	-1.6	1.5	1.3	-1.6	-1.6	-1.2	-1.0
Pavlov. Cond. lever latency	1.0	1.4	1.9	-0.7	1.2	1.3	-1.1	-1.1	-1.3	-1.4
Pavlov. Cond. magazine entry latency	2.4	2.8	3.8	2.0	-1.6	-1.6	1.7	1.7	1.6	1.6
Pavlov. Cond. change in total contacts	0.9	1.3	1.8	-1.3	1.2	0.9	-1.2	-1.2	-1.1	-0.9
Pavlov. Cond. index score	1.4	1.9	2.3	1.3	-1.3	-1.5	1.2	1.2	1.4	1.5
Pavlov. Cond. latency score	1.2	1.5	1.9	1.2	-1.2	-1.4	1.1	1.1	1.3	1.4
Pavlov. Cond. lever contacts	2.0	2.8	3.4	1.3	-1.7	-1.8	1.6	1.6	1.8	1.8
Pavlov. Cond. magazine entry number	0.6	0.7	0.9	-1.0	0.8	0.9	-0.8	-0.8	-0.8	-0.9
Pavlov. Cond. intertrial magazine entries	1.2	1.6	1.9	1.0	-1.4	-1.1	1.4	1.4	1.3	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.4	1.1	-1.0	-1.2	0.9	0.9	1.1	1.2
Pavlov. Cond. response bias	1.8	2.5	3.1	1.3	-1.5	-1.7	1.5	1.5	1.7	1.8
Time in closed arm before self-admin	0.7	0.8	1.1	0.1	0.9	0.9	-1.0	-1.0	-1.0	-0.9
Time in closed arm after self-admin	2.7	2.8	3.2	-1.8	1.6	1.7	-1.5	-1.5	-1.8	-1.8
Time in open arm before self-admin	2.1	2.3	4.1	-2.0	1.4	1.4	-1.3	-1.3	-1.5	-1.6
Time in open arm after self-admin	0.4	0.5	1.1	1.0	-0.5	-0.6	0.5	0.6	0.7	0.6
Bone: periosteal estimation	0.5	1.0	1.2	-1.0	1.1	1.0	-1.0	-1.0	-0.9	-0.9
Bone: periosteal perimeter	1.7	2.9	3.3	-1.4	1.8	1.8	-1.7	-1.7	-1.8	-1.8
Bone: post-yield work	0.5	0.7	0.9	-0.8	0.9	0.7	-0.9	-0.9	-0.7	-0.6
Progressive ratio test 1 active lever presses	0.3	0.3	0.6	-0.6	-0.6	-0.8	0.4	0.4	0.7	0.6
Progressive ratio test 1 breakpoint	0.2	0.2	0.4	-0.6	-0.4	-0.6	0.3	0.3	0.6	0.5
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.5	-0.7	0.3	0.1	-0.4	-0.4	-0.3	-0.3
Progressive ratio test 2 active lever presses	0.2	0.2	1.4	-1.2	-0.0	-0.2	-0.0	-0.0	0.2	0.1
Progressive ratio test 2 breakpoint	0.2	0.2	1.4	-1.2	0.1	-0.1	-0.1	-0.1	0.1	-0.0
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	-0.5	-0.3	-0.4	0.2	0.2	0.4	0.3
Incentive Sensitization - Responses	0.1	0.1	0.4	-0.6	0.4	0.2	-0.3	-0.3	-0.3	-0.3
Incentive Sensitization - Breakpoint	0.3	0.4	0.7	-0.8	0.6	0.4	-0.6	-0.6	-0.5	-0.6
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.5	-1.2	0.7	0.6	-0.9	-0.8	-0.4	-0.4
Progressive ratio	0.0	0.0	0.1	-0.0	-0.1	0.2	0.2	0.1	-0.0	-0.0
Food seeking constrained by brief footshock	0.3	0.4	1.8	-1.3	0.4	-0.1	-0.6	-0.7	-0.3	-0.2
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	-0.5	0.2	-0.3	-0.4	-0.3	-0.1	-0.0
Retroperitoneal fat weight	1.7	5.7	6.4	2.4	-2.5	-2.2	2.5	2.5	2.3	2.3
Reaction time number correct	1.4	2.0	2.4	1.1	-1.5	-1.5	1.3	1.3	1.5	1.6
Reaction time mean minus median	0.2	0.2	0.3	0.1	0.4	0.6	-0.4	-0.4	-0.6	-0.5
Reaction time mean minus median AUC	0.4	0.5	0.7	-0.4	0.7	0.7	-0.7	-0.7	-0.8	-0.7
Reaction time num false alarms	0.2	0.3	0.5	0.7	-0.6	-0.4	0.5	0.5	0.6	0.5
Reaction time num false alarms AUC	0.0	0.0	0.1	0.4	-0.2	-0.1	0.1	0.1	0.2	0.2
Reaction time trials correct on left	1.4	2.0	2.4	1.1	-1.5	-1.5	1.3	1.3	1.5	1.6
Reaction time trials on left	1.4	2.1	2.5	1.2	-1.5	-1.5	1.3	1.4	1.5	1.6
Reaction time mean	0.2	0.3	0.6	-0.1	0.5	0.8	-0.4	-0.4	-0.8	-0.7
Reaction time mean AUC	0.3	0.4	0.7	-0.2	0.6	0.8	-0.5	-0.5	-0.8	-0.8
Median of all reaction times	0.2	0.2	0.4	-0.2	0.4	0.7	-0.3	-0.3	-0.7	-0.6
Reaction time omissions	0.4	0.6	2.6	1.6	-0.5	-0.5	0.5	0.5	0.6	0.6
Reaction time false alarm rate	0.4	0.6	0.8	-0.6	0.8	0.9	-0.8	-0.8	-0.7	-0.8
Reaction time premature initiation rate	1.1	1.5	2.1	0.6	-1.4	-1.2	1.5	1.4	1.1	1.1
Reaction time premature initiations	2.3	3.3	4.1	1.2	-2.0	-1.9	2.0	2.0	1.7	1.8
Std. dev. reaction times	0.4	0.5	0.8	0.0	0.7	0.8	-0.7	-0.7	-0.9	-0.7
Reaction time trials completed	1.4	2.1	2.5	1.2	-1.5	-1.5	1.3	1.4	1.5	1.6
Reaction time trials AUC	1.2	1.7	2.0	1.0	-1.4	-1.4	1.2	1.3	1.4	1.4
Run reversals in cocaine runway, females	0.1	0.1	0.3	0.2	0.4	0.1	-0.5	-0.5	-0.3	-0.3
Run reversals in cocaine runway, males	2.2	2.2	3.3	-0.1	1.6	1.4	-1.5	-1.5	-1.8	-1.8
Latency to leave start box in cocaine runway	0.3	0.4	0.8	-0.9	0.5	0.7	-0.5	-0.6	-0.4	-0.5
Latency to leave start box in cocaine runway, F	0.4	0.4	0.5	-0.6	0.6	0.7	-0.6	-0.6	-0.6	-0.6
Latency to leave start box in cocaine runway, M	0.3	0.3	1.2	-1.1	0.4	0.6	-0.4	-0.4	-0.0	-0.1
Std. dev. time between licks in bursts	1.7	2.0	2.5	1.3	-1.4	-1.6	1.3	1.3	1.5	1.5
Total sessions with >9 infusions	0.8	0.9	3.9	-2.0	0.6	0.6	-0.7	-0.7	-0.5	-0.6
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.4	-0.2	-0.4	0.2	0.2	0.2	0.2
Short access day 10 total inactive lever presses	0.1	0.1	0.2	0.1	-0.3	-0.4	0.4	0.4	0.3	0.3
Short access day 1 total infusions	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.1	-0.1	-0.1	-0.2
Short access day 10 total infusions	0.1	0.2	0.9	-1.0	-0.2	-0.1	0.2	0.2	0.2	0.1
Short access total infusions	0.1	0.1	0.7	-0.8	-0.2	-0.2	0.2	0.2	0.2	0.2
Short access day 1 locomotion	0.0	0.0	0.1	0.2	0.2	-0.0	-0.3	-0.3	-0.0	-0.0
Short access day 10 total locomotion	0.0	0.0	0.1	-0.1	0.2	0.1	-0.3	-0.3	-0.1	-0.0
Short access total locomotion	0.1	0.1	0.2	-0.4	0.3	0.2	-0.4	-0.4	-0.2	-0.1
One hour access (0.3 mA shock)	2.6	3.0	6.1	-2.5	1.6	1.8	-1.5	-1.5	-1.5	-1.5
Compulsive drug intake	1.8	1.8	3.6	-1.9	1.2	1.3	-1.3	-1.3	-1.1	-1.1
One hour access (shock baseline)	1.2	1.4	2.3	-1.5	1.1	1.2	-1.0	-1.0	-1.2	-1.2
Social response proportion	0.9	1.0	1.2	1.1	-0.9	-1.1	0.8	0.8	1.1	1.1
Social responses	0.1	0.1	0.7	0.9	-0.1	-0.2	-0.0	-0.0	0.2	0.1
Social time	0.7	0.9	3.1	1.8	-0.7	-0.7	0.6	0.6	0.8	0.8
Soleus weight	0.0	0.0	0.1	0.2	0.1	0.2	-0.2	-0.2	-0.1	-0.0
Bone: stiffness	2.3	3.6	4.6	-1.7	2.1	1.7	-2.1	-2.1	-1.7	-1.7
Tibialis anterior weight	9.4	32.1	37.9	-5.0	5.5	6.0	-5.4	-5.4	-6.2	-6.1
Time to tail flick, vehicle, before self-admin	0.9	1.0	1.3	-0.3	1.0	1.1	-1.0	-1.0	-1.2	-1.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	0.3	0.3	0.5	-0.3	-0.4	-0.2	-0.1
Time to tail flick, test, before self-admin	0.6	0.6	1.1	0.3	0.8	0.8	-0.6	-0.7	-1.0	-1.0
Time to tail flick, test, after self-admin	0.2	0.2	0.6	0.0	0.4	0.8	-0.3	-0.3	-0.5	-0.5
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.0	0.4	-0.7	-0.7	0.7	0.7	0.9	1.0
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.1	0.0	0.3	-0.0	-0.0	0.0	0.1
Tibia length	0.0	0.0	0.1	0.1	-0.1	0.1	0.2	0.2	-0.0	-0.2
Ambulatory time before self-admin	0.1	0.1	0.8	-0.9	0.0	-0.1	-0.0	-0.0	-0.0	-0.1
Ambulatory time after self-admin	1.5	1.6	2.6	-0.1	-1.4	-1.4	1.6	1.6	1.2	1.1
Bone: tissue strength	1.3	1.3	1.7	-1.3	1.1	1.1	-1.2	-1.2	-1.1	-1.1
Total heroin consumption	0.1	0.1	0.2	-0.4	-0.2	-0.2	0.3	0.3	0.2	0.2
Bone: trabecular number	0.2	0.2	0.5	0.7	-0.4	-0.5	0.5	0.5	0.5	0.5
Bone: trabecular spacing	0.5	0.6	2.4	-1.6	0.5	0.6	-0.6	-0.6	-0.6	-0.7
Bone: trabecular thickness	0.0	0.0	0.2	0.4	0.1	0.2	0.0	0.0	-0.1	-0.2
Bone: trabecular tissue density	2.1	3.0	3.5	-1.6	1.8	1.7	-1.9	-1.9	-1.5	-1.7
Water consumed over 24 hours	0.9	1.1	1.3	0.7	-1.1	-1.0	1.2	1.2	1.0	1.1
Number of responses in last shaping day	0.6	0.7	2.6	1.6	-0.6	-0.6	0.4	0.4	0.7	0.6